Src

Summary

Gene Symbol: Src
Description: SRC proto-oncogene, non-receptor tyrosine kinase
Alias: ASV, SRC1, THC6, c-SRC, p60-Src, proto-oncogene tyrosine-protein kinase Src, proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Species: human

Top Publications

  1. ncbi Src kinase regulation by phosphorylation and dephosphorylation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 331:1-14. 2005
  2. doi Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4340, USA
    Dev Cell 14:25-36. 2008
  3. ncbi Identification of Itk/Tsk Src homology 3 domain ligands
    S C Bunnell
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 271:25646-56. 1996
  4. ncbi Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    C H Lee
    The Rockefeller University, New York, New York 10021, USA
    Cell 85:931-42. 1996
  5. pmc Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
  6. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
  7. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
  8. ncbi Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells
    I Ta Lee
    Department of Physiology and Pharmacology
    J Immunol 181:5098-110. 2008
  9. doi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
  10. ncbi c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003

Research Grants

  1. Programmed Adipogenesis and Lipid Dysregulation
    Mina Desai; Fiscal Year: 2009
  2. Henry Klar Yaggi; Fiscal Year: 2016
  3. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2010
  4. Mina Desai; Fiscal Year: 2014
  5. A Continuous Monitor for Arsenic in Drinking Water
    William Dietze; Fiscal Year: 2004
  6. RICHARD ALAN KATZ; Fiscal Year: 2016
  7. Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Water
    KING WANG; Fiscal Year: 2009
  8. Treatment of Sleep Disordered Breathing in Atrial Fibrillation
    SEAN MICHAEL CAPLES; Fiscal Year: 2010
  9. Point-of-Care Tests for Blood Lead Levels in Children
    ROBERT W HENKENS; Fiscal Year: 2013
  10. Dorothea L Sawicki; Fiscal Year: 2016

Detail Information

Publications307 found, 100 shown here

  1. ncbi Src kinase regulation by phosphorylation and dephosphorylation
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 331:1-14. 2005
    b>Src and Src-family protein-tyrosine kinases are regulatory proteins that play key roles in cell differentiation, motility, proliferation, and survival...
  2. doi Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4340, USA
    Dev Cell 14:25-36. 2008
    ..Ang1 inhibits the activation of Src by VEGF, the most upstream component of the pathway linking VEGF receptors to VE-cadherin internalization...
  3. ncbi Identification of Itk/Tsk Src homology 3 domain ligands
    S C Bunnell
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 271:25646-56. 1996
    ..SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.
  4. ncbi Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    C H Lee
    The Rockefeller University, New York, New York 10021, USA
    Cell 85:931-42. 1996
    ..The Nef-SH3 structure also reveals how high affinity and specificity in the SH3 interaction is achieved by the presentation of the PxxP motif within the context of the folded structure of Nef...
  5. pmc Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
    ..05). Antisense oligodeoxynucleotides (ODNs) and inhibitors of Src, PI3K, p38, and NFkappaB significantly reduced rhMIF-induced MN VCAM-1 and ICAM-1 expression (P < .05)...
  6. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
    ..in vitro, and this transcriptional upregulation was found to be stimulated by the HIV viral protein Nef in a Src kinase-and Stat3-dependent manner...
  7. pmc HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    Jennifer Van Grol
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11733. 2010
    ..Blockade of autophagy was dependent on Src-Akt and STAT3 triggered by HIV-1 Tat and IL-10...
  8. ncbi Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells
    I Ta Lee
    Department of Physiology and Pharmacology
    J Immunol 181:5098-110. 2008
    ..by transfection with dominant negative mutants of TLR2 and MyD88, by pretreatment with the inhibitors of c-Src (PP1), NADPH oxidase (diphenylene iodonium chloride (DPI) and apocynin (APO)), and reactive oxygen species (ROS) ..
  9. doi Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
    ..protein tau can associate with various other proteins in addition to tubulin, including the SH3 domains of Src family tyrosine kinases...
  10. ncbi c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003
    ..a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2)...
  11. pmc The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1
    Davide Gianni
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2984-94. 2008
    ..In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1...
  12. doi Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells
    Shue Fen Luo
    Department of Internal Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Toxicol Appl Pharmacol 237:8-21. 2009
    ..up-regulation of VCAM-1, which was inhibited by pretreatment with selective inhibitors of PKCalpha (Gö6976), c-Src (PP1), NADPH oxidase [diphenylene iodonium (DPI) and apocynin (APO)], intracellular calcium chelator (BAPTA/AM), PI-..
  13. pmc Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
    Jennifer L Sallee
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14997-5006. 2009
    ..These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability...
  14. ncbi Three-dimensional structure of the tyrosine kinase c-Src
    W Xu
    Laboratory of Molecular Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 385:595-602. 1997
    The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state...
  15. pmc Elevated c-Src and c-Yes expression in malignant skin cancers
    Jang Hyun Lee
    Molecular Cancer Research Center, College of Medicine, Soonchunhyang University, Chunan, Korea
    J Exp Clin Cancer Res 29:116. 2010
    b>Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis...
  16. pmc Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance
    Hope A Sansing
    Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center New Orleans, School of Dentistry, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 406:171-6. 2011
    ..Knockdown of effectors in the oral carcinoma HN12 cells revealed that p130Cas, Dek, Src and talin were required for invasion through Matrigel...
  17. ncbi Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation
    W Cao
    Departments of Psychiatry and Behavioral Sciences, Pharmacology, and Medicine and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38131-4. 2000
    ..We previously showed that c-Src is required for ERK activation by beta(2)AR and that it is recruited to activated beta(2)AR through binding of the ..
  18. pmc Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    ..implicated in integrin-mediated signal transduction pathways and in the process of oncogenic transformation by v-Src. Elevation of FAK's phosphotyrosine content, following both cell adhesion to extracellular matrix substrata and ..
  19. ncbi TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    B R Wong
    Laboratory of Immunology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 4:1041-9. 1999
    ..that TRANCE activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6...
  20. ncbi Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
    Steven J Schreiner
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 277:45680-7. 2002
    STAT3 is a member of a family of transcription factors with Src homology 2 (SH2) domains that are activated by tyrosine phosphorylation in response to a wide variety of cytokines and growth factors...
  21. doi Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features
    Mahitosh Mandal
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2088-100. 2008
    ..In the current study, the expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HNSC...
  22. ncbi Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase
    A K Somani
    Department of Medicine, University of Toronto and The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 272:21113-9. 1997
    Activation of the cellular Src tyrosine kinase depends upon dephosphorylation of the carboxyl-terminal inhibitory tyrosine phosphorylation site...
  23. ncbi Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer
    Maricarmen D Planas-Silva
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 341:73-81. 2006
    The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis...
  24. ncbi Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor
    Tracy Criswell
    Department of Radiation Oncology and Program in Molecular and Cellular Basis of Disease, Laboratory of Molecular Stress Responses, Case Comprehensive Cancer Center, Cleveland, Ohio 44106 7285, USA
    J Biol Chem 280:14212-21. 2005
    ..Activated IGF-1R then stimulates the downstream Src-Mek-Erk signal transduction cascade to ultimately transactivate the early growth response-1 (Egr-1) transcription ..
  25. pmc Regulation of RKIP binding to the N-region of the Raf-1 kinase
    Sungdae Park
    Medical University of Ohio, Department of Biochemistry and Cancer Biology, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
    FEBS Lett 580:6405-12. 2006
    ....
  26. doi SRC family kinase activity is up-regulated in hormone-refractory prostate cancer
    Oleg Tatarov
    Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Clin Cancer Res 15:3540-9. 2009
    Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival...
  27. doi Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1
    Marie Josée Demers
    Département d Anatomie et de Biologie Cellulaire, Universite de Sherbrooke, Quebec, Canada
    J Cell Biochem 107:639-54. 2009
    Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3-K/Akt-1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs)...
  28. pmc A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17
    T Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    Oncogene 30:611-8. 2011
    ..The main goal of this study was to evaluate the role of Src in activating ADAM17...
  29. pmc Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity
    Larbi Amazit
    Institut National de la Santé et de la Recherche Médicale Unité 693, 63 rue Gabriel Peri, Le Kremlin Bicêtre F 94276, France
    Mol Endocrinol 25:394-408. 2011
    ..PR), a ligand-activated transcription factor, recruits the primary coactivator steroid receptor coactivator-1 (SRC-1) gene promoters...
  30. doi Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway
    Ho Youl Lee
    Department of Life Science, University of Seoul, Siripdae gil 13, Dongdaemun Gu, Seoul, Korea
    Carcinogenesis 32:703-12. 2011
    ..Hydroxylated HIF-1α becomes a target for von Hippel-Lindau (VHL), which functions as an E3 ubiquitin ligase. Src prevents hydroxylation-dependent ubiquitinylation of HIF-1α, thus stabilizing it under normoxic conditions...
  31. pmc The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility
    C H Benes
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Oncogene 31:653-63. 2012
    Multiple SRC-family kinases (SFKs) are commonly activated in carcinoma and appear to have a role in metastasis through incompletely understood mechanisms...
  32. pmc MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    Shivani Ponnala
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:2065-75. 2011
    ..Taken together, these data provide new insights into the mechanisms underlying MMP-9-mediated hTERT expression in glioma proliferation...
  33. pmc Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability
    Xuefeng Zhang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 8:e1002461. 2012
    ..a Robo4 agonist, protected lymphatic endothelial cells from HIV-1 gp120-induced hyperpermeability by inhibiting c-Src kinase activation...
  34. ncbi Regulation of arrestin-3 phosphorylation by casein kinase II
    You Me Kim
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:16837-46. 2002
    ..states of arrestin-3 promote beta(2)-adrenergic receptor internalization and bind clathrin, beta-adaptin, and Src to comparable levels as wild type arrestin-3...
  35. pmc Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers
    Shyamali Basuroy
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 299:G186-95. 2010
    Recent studies showed that c-Src and phosphatidylinositol 3 (PI3) kinase mediate the oxidative stress-induced disruption of tight junctions in Caco-2 cell monolayers...
  36. doi MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1
    Qiang Shen
    Department of Laboratory Medicine and Pathology, 5B4 21 Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, AB, Canada T6G 2R7
    Mol Cancer Res 6:555-67. 2008
    ..Further, we show that these MUC1/ICAM-1 interaction-initiated lamellipodial and filopodial protrusions require Src family kinase and CT10 regulator of kinase like (CrkL) accompanied by the rapid formation of a Src-CrkL signaling ..
  37. ncbi Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1
    C Zhao
    Department of Biochemistry and Molecular Biology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    J Biol Chem 274:19649-54. 1999
    ..This is the first evidence that an intracellular molecule with a PH domain operates as a negative effector in signal relay to the regulation of gene expression...
  38. ncbi Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia
    Tod A Brown
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 279:14772-83. 2004
    ..Phosphorylation of gp140 and p80 are mediated by Src family kinases at multiple Tyr residues including Tyr(734). Dephosphorylation is mediated by PTP(s)...
  39. ncbi PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells
    Yutaro Obara
    The Vollum Institute, L474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 117:6085-94. 2004
    Recent studies suggest that the tyrosine kinase Src plays an important role in the hormonal regulation of extracellular signal-regulated kinases (ERKs) via cyclic AMP (cAMP)...
  40. pmc p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    Isabel Chu
    Braman Family Breast Cancer Institute of the University of Miami Sylvester Comprehensive Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell 128:281-94. 2007
    ..Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88...
  41. ncbi Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity
    Roxana Pincheira
    Department of Surgery and Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    J Immunol 181:1288-98. 2008
    ..In this study, we show that TNFR1 associates with Jak2, c-Src, and PI3K in various cell types...
  42. ncbi PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation
    Shudong Zhu
    Department of Biochemistry and Molecular Biology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada
    Cancer Res 67:10129-37. 2007
    b>Src-specific activity has been reported to be elevated in a high percentage of colon cancer cell lines and tumors, but the underlying mechanisms are largely unknown...
  43. pmc Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration
    Li Qin
    Department of Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 71:1742-51. 2011
    ..Steroid receptor coactivator-1 (SRC-1 or NCOA1) is overexpressed in a subset of breast cancers with poor prognosis...
  44. ncbi Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 282:26897-907. 2007
    ..PGC-1beta interacts directly with the hinge/AF-2a and LBD regions but indirectly and via the coactivator SRC-1 with the N-terminal domain...
  45. pmc Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation
    H J Kim
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Korea
    Mol Cell Biol 19:6323-32. 1999
    ..sites for basal transcription factors TBP and TFIIA, transcription integrators steroid receptor coactivator 1 (SRC-1) and CBP-p300, and nuclear receptors, as demonstrated by the glutathione S-transferase pull-down assays and the ..
  46. pmc Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta
    Anna Ghelli
    Dipart di Biologia Ev Sp, Via Irnerio 42, Universita di Bologna, Bologna, Italy
    Biochem J 366:187-93. 2002
    ..in the presence of 4-amino-5-(4-methylphenyl)-7-(t-butyl) pyrazolo [3,4-d] pyrimidine (PP1), an inhibitor of Src tyrosine kinase. Furthermore, the activity of Src kinase was slightly increased by SPP and inhibited by PP1...
  47. ncbi Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    Francesca Spinella
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 278:41294-301. 2003
    ..Gap junction closure was prevented by tyrphostin 25 and by the selective c-Src inhibitor, PP2...
  48. ncbi Fibronectin and type IV collagen activate ERalpha AF-1 by c-Src pathway: effect on breast cancer cell motility
    Diego Sisci
    Dipartimento Farmaco Biologico, Universita della Calabria, Arcavacata di Rende, Italy
    Oncogene 23:8920-30. 2004
    ..It is worth noting that c-Src activation is coincident with adhesion of cells to ECM proteins and that the inhibition of c-Src activity by PP2 or ..
  49. pmc SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis
    Hirohito Yamaguchi
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:19112-8. 2008
    ..The protein kinase c-Src binds to and directly phosphorylates Bif-1 on tyrosine 80...
  50. doi Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src
    Bo Cen
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 284:5265-76. 2009
    ..HINT1 directly interacts with the SCF(SKP2) ubiquitin ligase complex and inhibits the ubiquitylation of p27(KIP1). Src has been shown to phosphorylate p27(KIP1) and thus decrease its stability...
  51. pmc Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 284:20763-72. 2009
    ..In response to IL-1, catalytically active PTPalpha was required for Ca2+ release from the ER, Src-dependent phosphorylation of IP3R1 and accumulation of IP3R1 in focal adhesions...
  52. pmc 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression
    Venkatesh Kundumani-Sridharan
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Blood 115:2105-16. 2010
    ..15(S)-HETE-induced Egr-1 expression requires Src activation...
  53. pmc Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells
    Florence Sancier
    Institut de Recherches Servier, Croissy sur Seine, France
    PLoS ONE 6:e17237. 2011
    c-Yes, a member of the Src tyrosine kinase family, is found highly activated in colon carcinoma but its importance relative to c-Src has remained unclear...
  54. pmc Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion
    Ashlyn J Bernier
    Department of Laboratory Medicine and Pathology, 3 70 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Mol Cancer 10:93. 2011
    ..These events were found to involve Src kinase, a non-receptor tyrosine kinase also implicated in breast cancer initiation and progression...
  55. pmc Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766
    Li Zou
    Gastroenterology Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:7190-202. 2012
    ..Complementary genetic and pharmacologic approaches identify that the non-receptor tyrosine kinase Src is required for FN transactivation of FGFR1...
  56. pmc The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells
    Yong Chao Ma
    Department of Biochemistry and Molecular Biology, Cancer Institute, Capital Medical University, Beijing, China
    PLoS ONE 7:e33414. 2012
    ..the present study, we found that the Notch-1-Furin interaction is regulated by the non-receptor tyrosine kinase, c-Src. c-Src and Notch-1 are physically associated, and this association is responsible for Notch-1 processing and ..
  57. pmc A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Nat Med 18:1102-11. 2012
    ..An SRC-1-null mouse model reveals that the mouse SRC-1 gene has an essential role in endometriosis progression...
  58. ncbi Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations
    H J Kim
    College of Pharmacy, Chonnam National University, Kwangju 500 757, Korea
    J Biol Chem 273:28564-7. 1998
    Steroid receptor coactivator-1 (SRC-1) specifically bound to serum response factor (SRF), as demonstrated by glutathione S-transferase pull down assays, and the yeast and mammalian two-hybrid tests...
  59. ncbi TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Eur J Biochem 270:1257-68. 2003
    ..We found that IL-1-mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src-induced ..
  60. pmc Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway
    M W Wooten
    Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
    Mol Cell Biol 21:8414-27. 2001
    ..phosphorylation and activation of PKC-iota were inhibited in a dose-dependent manner by both PP2 and K252a, src and TrkA kinase inhibitors. Purified src was observed to phosphorylate and activate PKC-iota in vitro...
  61. ncbi Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase
    Yi Wu
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Tamaho, Nakakoma, Yamanashi, Japan
    Blood 101:3469-76. 2003
    ..Recent studies have implied that activation of Src family kinases is involved in GPIb-mediated platelet activation, although the related signal transduction pathway ..
  62. pmc Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1
    Zhongjian Xie
    Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
    Mol Biol Cell 16:3236-46. 2005
    ..In the present study, we investigated whether the activation of PLC-gamma1 by nonreceptor kinases such as src and fyn plays a role in mediating this process...
  63. ncbi c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK
    Justin M Summy
    University of Texas MD Anderson Cancer Center, Department of Cancer Biology, Houston, TX 77054, USA
    Pancreas 31:263-74. 2005
    ..aberrantly activated and/or overexpressed in pancreatic tumors, including the nonreceptor protein tyrosine kinase Src. The goal of this study was to determine the role of Src in regulating VEGF expression and angiogenic potential in ..
  64. ncbi TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src
    Kent Z Q Wang
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Sci 119:1579-91. 2006
    ..It was observed that PI 3-kinase was activated either by treatment with IL-1 or by expression of either TRAF6, Src, MyD88 or dominant-positive PI 3-kinase, and resulted in the formation of long filopodia-like cellular protrusions ..
  65. pmc Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding
    Banibrata Sen
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Cancer Res 69:1958-65. 2009
    ..One promising molecular target in HNSCC is the Src family kinases (SFK)...
  66. pmc Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification
    Anna A Dudka
    CRUK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Cancer Res 70:3391-401. 2010
    ..Tyrosine phosphorylation of STAT3 was also dependent on concomitant FGFR-dependent activity of SRC and JAK kinases...
  67. ncbi Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Immunol 170:4767-75. 2003
    ..A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter ..
  68. pmc Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly
    Qin Feng
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 26:7846-57. 2006
    ..Steroid receptor coactivator 3 (SRC-3) coactivator phosphorylation has been shown to regulate coactivator complex assembly, but the mechanisms by which ..
  69. pmc Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients
    Kan V Lu
    Department of Pathology and Laboratory Medicine, University of California Los Angeles David Geffen School of Medicine, USA
    Cancer Res 69:6889-98. 2009
    ..However, clinical responses to EGFR inhibitors are infrequent and short-lived. We show that the Src family kinases (SFK) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell ..
  70. ncbi Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochem Biophys Res Commun 228:662-8. 1996
    ..The major autophosphorylation site is tyrosine-397, which interacts with the Src homology 2 (SH2) domain of Src-family kinases including Src and Fyn...
  71. ncbi Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines
    J D Bjorge
    Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary Health Sciences Centre, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 275:41439-46. 2000
    c-Src tyrosine kinase activity is elevated in several types of human cancer, and this has been attributed to elevated c-Src expression levels, increased c-Src specific activity, and activating mutations in c-Src...
  72. ncbi Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
    T B van Dijk
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 96:3406-13. 2000
    ..These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling...
  73. ncbi Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity
    J Park
    Friedrich Miescher Institute, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 276:37459-71. 2001
    ..Both of these residues can be phosphorylated by v-Src tyrosine kinase in vitro, and co-expression of v-Src leads to tyrosine phosphorylation and activation of PDK1...
  74. ncbi Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin
    M A Chellaiah
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
    J Biol Chem 276:47434-44. 2001
    ..Here we show that gelsolin coprecipitates some of the focal adhesion-associated proteins such as c-Src, phosphoinositide 3-kinase (PI3K), p130(Cas), focal adhesion kinase, integrin alpha(v)beta(3), vinculin, talin, and ..
  75. ncbi Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis
    Marisa Dolled-Filhart
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin Cancer Res 9:594-600. 2003
    ....
  76. ncbi Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways
    Juan J Acosta
    Instituto de Investigaciones Biomédicas A Sols, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Endocrinol 17:2268-82. 2003
    ..Here we studied the role of c-Src on PRL-stimulated proliferation of T47D and MCF7 breast cancer cells...
  77. ncbi Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation
    Ya Jen Chang
    Department of Pharmacology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan
    Mol Pharmacol 66:1465-77. 2004
    ..Phosphatidylinositol-specific phospholipase C (PI-PLC), protein kinase C (PKC), and Src inhibitors inhibited COX-2 induction...
  78. pmc Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway
    John R Basile
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell Biol 25:6889-98. 2005
    ..the activation of an intracellular tyrosine kinase cascade that involves the sequential activation of PYK2 and Src. This results in the tyrosine phosphorylation of Plexin-B1, the rapid recruitment of a multimeric signaling complex ..
  79. pmc Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
    Satu Kärkkäinen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, Tampere 33014, Finland
    EMBO Rep 7:186-91. 2006
    We have determined the human genome to contain 296 different Src homology-3 (SH3) domains and cloned them into a phage-display vector...
  80. ncbi c-Src/histone deacetylase 3 interaction is crucial for hepatocyte growth factor dependent decrease of CXCR4 expression in highly invasive breast tumor cells
    Emanuela Matteucci
    Institute of General Pathology, School of Medicine, University of Milan, via Luigi Mangiagalli, 31 20133 Milan, Italy
    Mol Cancer Res 5:833-45. 2007
    ..invasive) breast carcinoma cells, and here, we show that completely different molecular mechanisms downstream of c-Src activation were involved...
  81. doi Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex
    Yong Bae Kim
    Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110 799, Korea
    J Biol Chem 283:10089-96. 2008
    ..with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on ILK expression and c-Src activity...
  82. ncbi Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
    D D Schlaepfer
    Salk Institute for Biological Studies, Molecular Biology and Virology Laboratory, La Jolla, California 92037, USA
    J Biol Chem 272:13189-95. 1997
    ..with integrin receptors, and FN-stimulated phosphorylation of FAK at Tyr-397 and Tyr-925 promotes the binding of Src family PTKs and Grb2, respectively...
  83. ncbi Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
    A H Zisch
    The Burnham Institute, La Jolla, California 92037, USA
    Oncogene 16:2657-70. 1998
    ..sites of the Eph receptors EphA3, EphA4, and EphB2 in embryonic retina serve as binding sites for the Src-homology 2 (SH2) domain of Src kinase...
  84. ncbi c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells
    N Rahimi
    Department of Pathology, Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 273:33714-21. 1998
    ..The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration; these functions are also ..
  85. ncbi Inhibition of Src by direct interaction with protein phosphatase 2A
    N Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    FEBS Lett 505:460-4. 2001
    In this study, we report that Src kinase is inhibited by protein phosphatase 2A (PP2A), a serine/threonine phosphatase. We carried out experiments in vitro using purified PP2A (AC dimer) and full-length v-Src or truncated forms of v-Src...
  86. ncbi Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b
    Elena B Kabotyanski
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 278:17218-27. 2003
    Stat5 is activated by a broad spectrum of cytokines, as well as non-receptor tyrosine kinases, such as Src. In this study, the DNA binding properties of the two closely related Stat5 proteins, Stat5a and Stat5b, induced either by ..
  87. ncbi Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215
    Ratna K Vadlamudi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    FEBS Lett 543:76-80. 2003
    ..influence the migratory potential of breast cancer cells, we have used phospho-specific antibodies against c-Src kinase and focal adhesion kinase (FAK)...
  88. pmc Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower T6, Health Science Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Biol Chem 278:46533-40. 2003
    Cas is a member of the focal adhesion complex. Phosphorylation of Cas by Src is an important event leading to cell transformation. Using mass spectrometry, we have mapped 11 sites in Cas that are phosphorylated by Src...
  89. doi Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells
    S Hiscox
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff, Wales, UK
    Breast Cancer Res Treat 115:57-67. 2009
    ..we have shown that acquisition of resistance to tamoxifen in breast cancer cells is accompanied by an elevation in Src kinase activity which promotes an aggressive, invasive phenotype in vitro...
  90. pmc Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma
    Priya Koppikar
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 14:4284-91. 2008
    ..b>Src family kinases, including c-Src, mediate a variety of intracellular or extracellular signals that contribute to ..
  91. pmc Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion
    Hiroshi Nozawa
    Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cancer Res 14:4336-44. 2008
    ..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion.
  92. ncbi SH2 domain specificity and activity modified by a single residue
    L E Marengere
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 369:502-5. 1994
    Many intracellular targets of protein-tyrosine kinases possess Src homology 2 (SH2) domains that directly recognize phosphotyrosine-containing sites on autophosphorylated growth factor receptors and cytoplasmic proteins, and thereby ..
  93. pmc Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains
    Z Weng
    ARIAD Pharmaceuticals, Cambridge, Massachusetts 02139
    Mol Cell Biol 14:4509-21. 1994
    b>Src homology 3 (SH3) domains mediate protein-protein interactions necessary for the coupling of cellular proteins involved in intracellular signal transduction...
  94. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    ..NIH3T3 fibroblasts to fibronectin promotes SH2-domain-mediated association of the GRB2 adaptor protein and the c-Src protein-tyrosine kinase (PTK) with FAK in vivo, and also results in activation of mitogen-activated protein kinase (..
  95. pmc A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
    R Sakai
    Molecular Biology Division, Jichi Medical School, Tochigi, Japan
    EMBO J 13:3748-56. 1994
    p47v-crk (v-Crk), a transforming gene product containing Src homology (SH)-2 and -3 domains, induces an elevated level of tyrosine phosphorylation of several cellular proteins...
  96. pmc Activation and association of Stat3 with Src in v-Src-transformed cell lines
    X Cao
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Mol Cell Biol 16:1595-603. 1996
    ..Stat3 is also activated by CSF-1, possibly through CSF-1 receptor-c Src association in NIH 3T3 cells overexpressing CSF-1 receptors...
  97. pmc Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 16:5623-33. 1996
    ..We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D...
  98. ncbi A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
    I Dikic
    Department of Pharmacology, New York University Medical Center, 10016, USA
    Nature 383:547-50. 1996
    ..Candidate protein tyrosine kinases that link G-protein-coupled receptors with MAP kinase include Src family kinases, the epidermal growth factor receptor, Lyn and Syk...
  99. pmc Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins
    V J Fincham
    Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, Scotland
    J Cell Biol 135:1551-64. 1996
    We have isolated Swiss 3T3 subclones that are resistant to the mitogenic and morphological transforming effects of v-Src as a consequence of aberrant translocation of the oncoprotein under low serum conditions...
  100. ncbi c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function
    J S Biscardi
    Department of Microbiology and Cancer Center, Box 441, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 274:8335-43. 1999
    ..that interactions between the epidermal growth factor receptor (EGFR) and the nonreceptor tyrosine kinase c-Src may contribute to an aggressive phenotype in multiple human tumors...
  101. ncbi Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
    S C Bunnell
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 275:2219-30. 2000
    ..Second, the Itk proline-rich region binds to Grb2 and LAT. Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated SLP-76...

Research Grants62

  1. Programmed Adipogenesis and Lipid Dysregulation
    Mina Desai; Fiscal Year: 2009
    ..Specifically, (i) decreased co- repressor, NCoR, (ii) increased co-activator, SRC1, and (iii) reduced inhibition of PPAR[unreadable]2 via ERK1/2-mediated phosphorylation...
  2. Henry Klar Yaggi; Fiscal Year: 2016
    ..treatment of CSA with continuous positive airway pressure (CPAP) or adaptive pressure-support servo-ventilation (ASV), although the single long-term outcome study of CPAP therapy for CSA in HF found no difference in transplant-free ..
  3. Metabolism and Toxicity of Arsenic in the Human Liver
    Miroslav Styblo; Fiscal Year: 2010
    ..that express AS3MT methylate iAs to methyl-As (MAs) and dimethyl-As (DMAs) species that contain either AsIII or AsV. These metabolites are also found in urine of individuals exposed to iAs from environmental sources and patients ..
  4. Mina Desai; Fiscal Year: 2014
    ..adipose tissue PPAR?2 gene expression with downregulation of co-repressor NCoR, and upregulation of co-activator SRC1. Thus, the changes in co-regulators may well be the fundamental underlying factor(s) contributing to programmed ..
  5. A Continuous Monitor for Arsenic in Drinking Water
    William Dietze; Fiscal Year: 2004
    TraceDetect and Frontier Geosciences aim to develop a stand-alone ASV instrument with performance that is comparable to or better than most atomic spectroscopic detectors currently used for the determination of arsenic in waters...
  6. RICHARD ALAN KATZ; Fiscal Year: 2016
    ..It was established decades ago that the prototype avian sarcoma virus (ASV) DNA provirus is subject to epigenetic silencing in mammalian cells, and this system will continue to be studied as ..
  7. Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Water
    KING WANG; Fiscal Year: 2009
    ..to measure arsenic include Colorimetric Test Kits, Portable X-ray Fluorescence (XRF), Anodic Stripping Voltammetry (ASV), and Laser Induced Breakdown Spectroscopy (LIBS), etc, however all of them have different disadvantages to be ..
  8. Treatment of Sleep Disordered Breathing in Atrial Fibrillation
    SEAN MICHAEL CAPLES; Fiscal Year: 2010
    ..Utilizing adaptive servoventilation (ASV), a newer PAP device effective for treatment of both OSA and CSA, we will measure important cardiovascular and ..
  9. Point-of-Care Tests for Blood Lead Levels in Children
    ROBERT W HENKENS; Fiscal Year: 2013
    ..is the creation and development of a completely new biosensor, one that can support Anodic Stripping Voltammetry (ASV) assays of blood lead with smaller samples and without any pre- test sample processing...
  10. Dorothea L Sawicki; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The American Society for Virology (ASV) seeks a multi-year block grant to provide partial support for pre-doctoral students, post-doctoral fellows and U.S...
  11. American Society for Virology Junior Scientist Travel Request
    Dorothea L Sawicki; Fiscal Year: 2010
    The American Society for Virology (ASV) wishes to provide, through this five-year block grant, partial support for the travel of 45 pre-doctoral students, 25 post-doctoral fellows, and 4 U.S...
  12. MARK DAVID ANDRAKE; Fiscal Year: 2016
    ..models of full-length unliganded apo-IN monomers and dimers in solution, using avian sarcoma virus (ASV) IN. The results revealed a dimer architecture (called a reaching dimer) that was previously unsuspected...
  13. INTERNATIONAL CONGRESS OF VIROLOGY
    ROLAND RUECKERT; Fiscal Year: 1990
    ..The American Society for Virology (ASV) recognizes a critical need to support the future of virus research and its application to today's demanding ..
  14. Structure/Function Analysis of the Retrovirus Integrase
    JONATHAN P LEIS; Fiscal Year: 2010
    ..strategy that substituted unique amino acid residues from structurally related positions in avian sarcoma virus (ASV) into HIV-1 IN...
  15. A Novel Sensor for total Mercury in Fish Tissue
    SHANTHA SARANGAPANI; Fiscal Year: 2002
    ..electrodes with dendrimer-gold nano composite for the "in situ" anodic stripping voltammetric analysis (ASV) of total mercury in fish tissue samples. Alternate methods of sample preparations will be tested...
  16. INTL CONG OF VIROLOGY, SAN FRANCISCO, ASV TRAVEL REQUEST
    PATRICIA SPEAR; Fiscal Year: 2005
    ..The ASV considers one excellent way to stimulate and aid junior researchers in their future work is to enable them to ..
  17. INTERNATIONAL CONGRESS OF VIROLOGY, SYDNEY
    Thomas Shenk; Fiscal Year: 1999
    The American Society for Virology (ASV) requests funds to provide partial support for the travel of selected outstanding junior virologists to participate in the 11th International Congress of Virology (ICV) to be held August, 1999 in ..
  18. CRF-Type-2 Receptor Antagonists for Anxiety
    Kathleen Gogas; Fiscal Year: 2002
    ..and urocortin II verified the importance of the CRF2 receptor in anorectic behavior, but the antisauvagine-30 (ASV-30) data also suggested that the CRF2 receptor may be involved in emotional behavior and anxiety...
  19. INTL CONG OF VIROLOGY, PARIS
    DENNIS O CALLAGHAN; Fiscal Year: 2002
    The American Society for Virology (ASV) requests funds to provide partial support for the travel of selected outstanding junior virologists to participate in the 12th International Congress of Virology (ICV) to be held 27 July - 1 Aug ..
  20. INT CONGRESS OF VIROLOGY GLASGOW ASV BLOC TRAVEL REQUEST
    MAX SUMMERS; Fiscal Year: 1993
    The objective of this proposal by the American Society for Virology (ASV) is to provide partial support for the travel of selected outstanding junior American virologists to attend and participate in the Ninth International Congress of ..
  21. Understanding the Mechanism of Retrovirus Budding
    Jonathan Leis; Fiscal Year: 2009
    ..To understand the nature of these protein complexes, Gag polyproteins from avian sarcoma (ASV), human immunodeficiency, type I, (HIV-1) and Moloney murine leukemia (MuLV) viruses will be isolated from cells ..
  22. Crosslinking stabilization of integrase-DNA complexes
    ELENA PELETSKAYA; Fiscal Year: 2006
    ..We propose to obtain stabilized IN-DNA complexes suitable for structural and biochemical studies of HIV-1 and ASV integrase by chemically crosslinking the protein to nucleic acid, without distorting their structures...
  23. Natural Mutation at the Coactivator Binding Site of ER
    Mark Nichols; Fiscal Year: 2002
    ..experiments; 3) to isolate via RT-PCR and assay transcription with ER interacting! p160 coactivator clones SRC1, GRIP1, and NCOR cDNAs recovered from tissue samples, and 4) to isolate and identify further naturally occurring ER ..
  24. CONVECTION ENHANCED DRUG DELIVERY TO BRAIN TUMORS
    DENNIS GROOTHUIS; Fiscal Year: 2000
    ..Second, we will delivery antisense oligonucleotides (ODN) against VEGF and bFGF to ASV-induced gliomas in dogs to suppress tumor angiogenesis...
  25. AVIAN SARCOMA VIRUS TRANSFORMATION-SPECIFIC ANTIGENS
    Raymond Erikson; Fiscal Year: 1980
    ..This study is directed toward the identification of avian sarcoma virus (ASV)-coded non-virion proteins...
  26. INTEGRATION OF RNA TUMOR VIRUSES IN MAMMALIAN CELLS
    Carolyn Collins; Fiscal Year: 1980
    ..The overall objective of our research effort is to understand the control of integrated avian sarcoma virus (ASV) gene expression in a number of different ASV-infected transformed and revertant mammalian cell lines...
  27. ASV INTEGRASE--MECHANISM OF DNA BINDING AND RECOGNITION
    Isaac Wong; Fiscal Year: 2002
    ..titration techniques to elucidate the mechanism of cognate-site (CATT) recognition by the Avian Sarcoma Virus (ASV) integrase (IN) and to define the structure- function relationship between recognition and regulation of catalytic ..
  28. GENETIC STUDIES OF RNA TUMOR VIRUSES
    PIERO BALDUZZI; Fiscal Year: 1980
    ..The early interactions of cells and viruses (adsorption and penetration) using ASV and chick embryo fibroblasts of known resistance or susceptibility to ASV will be investigated with the sensitive ..
  29. ADAM FUNCTION IN NEURAL CREST CELLS
    Douglas DeSimone; Fiscal Year: 2006
    ..The ADAM 13 cytoplasmic tail has been shown to interact with SH3 domain containing proteins including Src1 and PACSIN-2. PACSIN-2 binding is also associated with a reduction in ADAM 13 functional activity in vivo...
  30. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  31. Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening
    RICHARD ALAN KATZ; Fiscal Year: 2010
    ..This process, termed "epigenetic silencing," is reversible, and the goal of the proposed research is to identify novel cellular processes that cause epigenetic silencing such that new therapies can be devised. ..
  32. International Congress of Virology, Istanbul, ASV Travel Request
    DOROTHEA SAWICKI; Fiscal Year: 2008
    Abstract The American Society for Virology (ASV) wishes to provide, through this block grant, partial support for the travel of 20 selected outstanding junior virologists to participate in the XIVth International Congress of Virology (..
  33. GFP-Based Assays to Probe Transcriptional Controls(RMI)
    Richard Katz; Fiscal Year: 2005
    ..The assays have the potential to reveal new lead compounds, as well as new gene targets for therapeutics. ..
  34. Acoustic and electrical hearing after Atoh1 treatment
    Bryan E Pfingst; Fiscal Year: 2010
    ....
  35. MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE
    BARBARA SLACK; Fiscal Year: 2001
    ..and tyrosine phosphorylation in response to muscarinic and EGF receptor activation, using dominant negative mutant Src, FAK and Pyk2 proteins and in vitro kinase assays...
  36. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  37. DNA MISMATCH REPAIR FUNCTIONAL GENETIC TESTS
    GRANT BITTER; Fiscal Year: 2002
    ..Data generated with this technology will allow accurate interpretation of genetic tests for HNPCC, sporadic cancers and common polymorphisms in MMR genes. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  38. FEATURES OF STIMULATION IMPORTANT FOR ELECTRICAL HEARING
    BRYAN PFINGST; Fiscal Year: 2003
    ..abstract_text> ..
  39. Functional Genetic Tests for Breast Cancer Diagnosis
    GRANT BITTER; Fiscal Year: 2003
    ..abstract_text> ..
  40. INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING
    BARBARA SLACK; Fiscal Year: 2003
    ..abstract_text> ..
  41. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
    ..these results will define the molecular mechanism through which cell adhesion regulates gene expression and wound repair in epithelium. ..
  42. Tissue Chips for Toxicology Evaluation
    A Gandolfi; Fiscal Year: 2004
    ..These studies should validate if we have developed an innovative approach to rapidly profile the toxicity of potential chemotherapeutic agents. ..
  43. Technology for DNA Damage Analysis and Biomarkers
    X Le; Fiscal Year: 2004
    ..The technology will also be useful for monitoring DNA damage induced by anticancer agents and for studying DNA repair, which is an essential protection mechanism against cancer initiation. ..
  44. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2006
    ..abstract_text> ..
  45. Role of p70 S6 Kinase in Regulating LAM Cell Growth
    Vera P Krymskaya; Fiscal Year: 2010
    ....
  46. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  47. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 2004
    ..We have also found that in neuronal cells, tau associates with the src family non-receptor tyrosine kinase fyn and that in vitro, a PXXP motif in tau interacts with the SH3 domain of src ..
  48. SIGNAL TRANSDUCTION BY TYROSINE KINASES
    Michael Weber; Fiscal Year: 2001
    ..These investigations will assess a) the role of PI 3-kinase b) the regulation of stress kinases, c) the participation of the bcl-2 family in IGF-I receptor signaling, and d) the role of a newly identified MEK activator. ..
  49. Role of AIB3 in Mammary Gland and Breast Cancer
    Jianming Xu; Fiscal Year: 2009
    ..It is very hopeful to identify AIB3 as an oncogene in the breast and a molecular target for breast cancer treatment. ..
  50. Androgen and Growth Factor Signaling in Prostate Cancer
    Michael Weber; Fiscal Year: 2008
    ..This research will be informative with respect to understanding the integration of steroid and growth factor signaling, as well as in identifying the optimal therapeutic targets for advanced prostate cancer. ..
  51. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005
    ..These studies will provide an understanding of components and mechanisms critical for regulating epithelial morphogenesis in development, wound repair and tumor invasion. ..
  52. Regulation of Outside-In Integrin Signaling in Platelets
    SANFORD SHATTIL; Fiscal Year: 2007
    ..Recent work from this laboratory has established that outside-in signaling in platelets requires Src family tyrosine kinases (SFKs), c-Src in particular, which bind to beta3 and are activated by allbbeta3 clustering ..
  53. TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    SANFORD SHATTIL; Fiscal Year: 2004
    ..abstract_text> ..
  54. Role of sex steroids in female TIEG-null mouse bone loss
    John Hawse; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  55. FUNCTIONAL EFFECTS OF DEAFNESS AND NEURAL STIMULATION
    BRYAN PFINGST; Fiscal Year: 2005
    ....