SQRDL

Summary

Gene Symbol: SQRDL
Description: sulfide quinone reductase-like (yeast)
Alias: CGI-44, PRO1975, SQOR, sulfide dehydrogenase like, sulfide:quinone oxidoreductase, mitochondrial
Species: human

Top Publications

  1. doi Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria
    Tatjana M Hildebrandt
    Institut fur Zoophysiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    FEBS J 275:3352-61. 2008
  2. doi Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes
    Emilie Lagoutte
    CNRS FRE3210, Universite Rene Descartes, Site Necker 156 rue de Vaugirard, 75730 Paris cedex15, France
    Biochim Biophys Acta 1797:1500-11. 2010
  3. ncbi Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite
    Michael R Jackson
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Biochemistry 51:6804-15. 2012
  4. doi The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613
    John M Hourihan
    Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 19:465-81. 2013
  5. ncbi A fission yeast gene for mitochondrial sulfide oxidation
    J G Vande Weghe
    Plant Gene Expression Center, U S Department of Agriculture Agricultural Research Service, Albany, California 94710, USA
    J Biol Chem 274:13250-7. 1999
  6. pmc Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
    Tun Tzu Yu
    Department of Physiology and The Cellular and Molecular Neuroscience of Sensory Systems Program, The University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 483:251-62. 2005
  7. pmc Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet
    Isabel Baiges
    Biochemistry and Biotechnology Department, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Mol Cell Proteomics 9:1499-513. 2010
  8. doi Proteomics reveals that redox regulation is disrupted in patients with ethylmalonic encephalopathy
    Johan Palmfeldt
    Research Unit for Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    J Proteome Res 10:2389-96. 2011
  9. doi The vertebrate homolog of sulfide-quinone reductase is expressed in mitochondria of neuronal tissues
    M Ackermann
    Department of Neurosurgery at the University Clinic, University of Regensburg, Regensburg, Germany
    Neuroscience 199:1-12. 2011

Scientific Experts

  • Tatjana M Hildebrandt
  • Johan Palmfeldt
  • Isabel Baiges
  • John M Hourihan
  • Michael R Jackson
  • M Ackermann
  • Emilie Lagoutte
  • Tun Tzu Yu
  • John D Hayes
  • J Gerry Kenna
  • Marilyn Schuman Jorns
  • Scott L Melideo
  • A L Pina
  • M Kubitza
  • A Brawanski
  • G Hauska
  • K Maier
  • Catherine Chaumontet
  • Frederic Bouillaud
  • Mireille Andriamihaja
  • Francois Blachier
  • Sabria Mimoun
  • J G Vande Weghe
  • Soma C Bose
  • Michael C Owen
  • Timothy S McClintock
  • Debra Hardin
  • Jeremy C McIntyre
  • D W Ow

Detail Information

Publications9

  1. doi Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria
    Tatjana M Hildebrandt
    Institut fur Zoophysiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    FEBS J 275:3352-61. 2008
    ..This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese...
  2. doi Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes
    Emilie Lagoutte
    CNRS FRE3210, Universite Rene Descartes, Site Necker 156 rue de Vaugirard, 75730 Paris cedex15, France
    Biochim Biophys Acta 1797:1500-11. 2010
    ..Consequently, the neural tissue would be more sensitive to sulfide poisoning. Our data disclose new constraints concerning the emerging signaling role of sulfide...
  3. ncbi Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite
    Michael R Jackson
    Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Biochemistry 51:6804-15. 2012
    Sulfide:quinone oxidoreductase (SQOR) is a membrane-bound enzyme that catalyzes the first step in the mitochondrial metabolism of H(2)S...
  4. doi The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613
    John M Hourihan
    Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 19:465-81. 2013
    ....
  5. ncbi A fission yeast gene for mitochondrial sulfide oxidation
    J G Vande Weghe
    Plant Gene Expression Center, U S Department of Agriculture Agricultural Research Service, Albany, California 94710, USA
    J Biol Chem 274:13250-7. 1999
    ....
  6. pmc Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
    Tun Tzu Yu
    Department of Physiology and The Cellular and Molecular Neuroscience of Sensory Systems Program, The University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 483:251-62. 2005
    ..Several of the genes encode proteins that participate in these biological processes, including ATP5g3, Ndufa9, Sqrdl, Mdh1, Got1, beta-2 tubulin, Capza1, Bin3, Tom1, Acl6, and similar to O-MACS...
  7. pmc Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet
    Isabel Baiges
    Biochemistry and Biotechnology Department, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Mol Cell Proteomics 9:1499-513. 2010
    ..A(2)-activating protein), METTL7B, SLC30A1, several G signaling proteins, and the sulfide-metabolizing ETHE1 and SQRDL (sulfide-quinone reductase-like) might be considered as drug targets for the treatment of metabolic syndrome.
  8. doi Proteomics reveals that redox regulation is disrupted in patients with ethylmalonic encephalopathy
    Johan Palmfeldt
    Research Unit for Molecular Medicine, Aarhus University Hospital, Skejby, Denmark
    J Proteome Res 10:2389-96. 2011
    ..Sulfide:quinone oxidoreductase (SQRDL), which takes part in the same sulfide pathway as ETHE1, was also underrepresented in EE patients...
  9. doi The vertebrate homolog of sulfide-quinone reductase is expressed in mitochondria of neuronal tissues
    M Ackermann
    Department of Neurosurgery at the University Clinic, University of Regensburg, Regensburg, Germany
    Neuroscience 199:1-12. 2011
    ..enzymes, one of which is sulfide-quinone oxidoreductase (SQR), known as sulfide-quinone reductase-like protein (SQRDL) in vertebrates...