SPARC

Summary

Gene Symbol: SPARC
Description: secreted protein acidic and cysteine rich
Alias: BM-40, OI17, SPARC, basement-membrane protein 40, secreted protein, acidic, cysteine-rich (osteonectin)
Species: human

Top Publications

  1. pmc The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors
    E W Raines
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:1281-5. 1992
  2. pmc SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells
    Heather M McClung
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neurosci Lett 419:172-7. 2007
  3. pmc Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression
    G Chen
    Clinic of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, Ulm 89075, Germany
    Br J Cancer 102:188-95. 2010
  4. doi Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients
    Maria Aparecida Nagai
    Disciplina de Oncologia, Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Breast Cancer Res Treat 126:1-14. 2011
  5. doi Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1
    Gail Workman
    Department of Vascular Biology, Benaroya Research Institute, Seattle, Washington 98101, USA
    J Cell Biochem 112:1003-8. 2011
  6. ncbi Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Immunol 176:5825-32. 2006
  7. doi Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells
    Catalina Atorrasagasti
    Gene Therapy Laboratory, Liver Unit School of Medicine, Austral University, Av Presidente Perón 1500, B1629ODT Derqui Pilar, Buenos Aires, Argentina
    Int J Cancer 126:2726-40. 2010
  8. doi Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas
    Suheyla Uyar Bozkurt
    Department of Pathology, Institute for Neurological Sciences, Marmara University, Istanbul, Turkey
    APMIS 117:651-9. 2009
  9. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
  10. pmc Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance
    C S Wang
    Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Taiwan
    Br J Cancer 91:1924-30. 2004

Research Grants

  1. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
  2. Effect of Osteoporosis on Spine Fusion
    BRIAN CROCKETT COOLEY; Fiscal Year: 2010
  3. AMY DODD BRADSHAW; Fiscal Year: 2015
  4. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
  5. AD OC TK/VAL GENE THERAPY CLINICAL CORRELATES
    Leland Chung; Fiscal Year: 2001
  6. EXTRACELLULAR MATRIX PROTEINS IN CELL AND ORGAN CULTURE
    Gloria Gronowicz; Fiscal Year: 1992
  7. Molecular Mechanisms of SPARC Mediated Glioma Invasion
    Jeremy N Rich; Fiscal Year: 2010
  8. Salivary Biomarkers to Predict Alveolar Bone Loss
    Frank Scannapieco; Fiscal Year: 2005
  9. NUTRITION, GENES AND HIP FRACTURE RISK IN UTAH
    Ronald Munger; Fiscal Year: 2000
  10. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2006

Detail Information

Publications221 found, 100 shown here

  1. pmc The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors
    E W Raines
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:1281-5. 1992
    ..Here we report the association of PDGF-AB and -BB, but not PDGF-AA, with the extracellular glycoprotein SPARC. Complexes of SPARC and 125I-labeled PDGF-BB or -AB were specifically immunoprecipitated by anti-SPARC ..
  2. pmc SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells
    Heather M McClung
    Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Neurosci Lett 419:172-7. 2007
    Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas and promotes glioma invasion...
  3. pmc Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression
    G Chen
    Clinic of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, Ulm 89075, Germany
    Br J Cancer 102:188-95. 2010
    Secreted protein acidic and rich in cysteine (SPARC) is a multi-faceted protein-modulating cell-cell and cell-matrix interactions...
  4. doi Prognostic value of NDRG1 and SPARC protein expression in breast cancer patients
    Maria Aparecida Nagai
    Disciplina de Oncologia, Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Breast Cancer Res Treat 126:1-14. 2011
    An increasing number of studies have shown altered expression of secreted protein acidic and rich in cysteine (SPARC) and N-myc down-regulated gene (NDRG1) in several malignancies, including breast carcinoma; however, the role of these ..
  5. doi Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1
    Gail Workman
    Department of Vascular Biology, Benaroya Research Institute, Seattle, Washington 98101, USA
    J Cell Biochem 112:1003-8. 2011
    b>SPARC (osteonectin/BM-40), a secreted matricellular protein that promotes cellular deadhesion and motility in wound healing, carcinogenesis, and inflammation, binds to the scavenger receptor stabilin-1 in alternatively activated ..
  6. ncbi Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC
    Julia Kzhyshkowska
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    J Immunol 176:5825-32. 2006
    The matricellular protein SPARC (secreted protein acidic and rich in cysteine) has been implicated in development, differentiation, response to injury, and tumor biology by virtue of its regulation of extracellular matrix production/..
  7. doi Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells
    Catalina Atorrasagasti
    Gene Therapy Laboratory, Liver Unit School of Medicine, Austral University, Av Presidente Perón 1500, B1629ODT Derqui Pilar, Buenos Aires, Argentina
    Int J Cancer 126:2726-40. 2010
    ..Current treatments are extremely disappointing. SPARC (Secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein with differential expression in ..
  8. doi Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas
    Suheyla Uyar Bozkurt
    Department of Pathology, Institute for Neurological Sciences, Marmara University, Istanbul, Turkey
    APMIS 117:651-9. 2009
    ..b>SPARC (secreted protein, acidic and rich in cysteine) (osteonectin) is a matricellular glycoprotein that regulates cell ..
  9. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    Secreted protein acidic and rich in cysteine (SPARC), a member of the family of matricellular proteins, regulates the interaction of cells with pleiotropic factors and proteins of the extracellular matrix (ECM)...
  10. pmc Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance
    C S Wang
    Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Taiwan
    Br J Cancer 91:1924-30. 2004
    ..Secreted Protein, Acidic and Rich in Cysteine (SPARC) (Osteonectins), one of the most highly expressed genes in both intestinal and diffuse gastric cancers in our ..
  11. ncbi Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    Jeffrey R Infante
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Clin Oncol 25:319-25. 2007
    b>SPARC (secreted protein acidic and rich in cysteine) is a protein involved in cell matrix interactions, wound repair, and cell migration, and has been reported to inhibit cancer growth...
  12. ncbi Osteonectin downregulates E-cadherin, induces osteopontin and focal adhesion kinase activity stimulating an invasive melanoma phenotype
    Darren J Smit
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
    Int J Cancer 121:2653-60. 2007
    ..These results indicate a central role for Osteonectin in the regulation of gene expression changes driving the progression of melanoma toward metastasis...
  13. pmc Secreted protein acidic and rich in cysteine (SPARC) in human skeletal muscle
    Louise H Jørgensen
    Institute of Clinical Research LHJ, SJP, JS, HDS, Odense, Denmark
    J Histochem Cytochem 57:29-39. 2009
    Secreted protein acidic and rich in cysteine (SPARC)/osteonectin is expressed in different tissues during remodeling and repair, suggesting a function in regeneration...
  14. doi The role of SPARC in the TRAMP model of prostate carcinogenesis and progression
    N Said
    Department of Urology, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 28:3487-98. 2009
    b>SPARC (Secreted Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and/or neighboring stroma...
  15. pmc The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
    P Bhoopathi
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA
    Br J Cancer 102:530-40. 2010
    Secreted protein acidic and rich in cysteine (SPARC), a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix and is capable of altering the growth of various cancers...
  16. pmc Relationship and prognostic significance of SPARC and VEGF protein expression in colon cancer
    Jian Fang Liang
    Dept of Pathology, First Clinical Medical College, Shanxi Medical University, Taiyuan City, Shanxi, China
    J Exp Clin Cancer Res 29:71. 2010
    b>SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis.
  17. pmc Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein
    Emily S Stieren
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 286:35689-98. 2011
    ..Our results support the notion that ubiquilin-1 chaperone activity is necessary to regulate the production of APP and its fragments and that diminished ubiquilin-1 levels may contribute to AD pathogenesis...
  18. pmc SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix
    H Sage
    Department of Biological Structure, University of Washington, Seattle 98195
    J Cell Biol 109:341-56. 1989
    b>SPARC (Secreted Protein Acidic and Rich in Cysteine) is a Ca+2-binding glycoprotein that is differentially associated with morphogenesis, remodeling, cellular migration, and proliferation...
  19. ncbi Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture
    H Sage
    J Biol Chem 259:3993-4007. 1984
    ..Its synthesis by normal mesenchymal cells and by malignant or transformed cells of both ectodermal and endodermal origin suggests a general role in cell function that is independent of transformation...
  20. ncbi Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence
    E H Sage
    Department of Biological Structure, University of Washington School of Medicine, Seattle 98195
    J Cell Biochem 57:127-40. 1995
    b>SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin and BM-40) is a metal-binding glycoprotein secreted by a variety of cultured cells and characteristic of tissues undergoing morphogenesis, remodeling, and ..
  21. ncbi Expression of SPARC in normal and fibrotic livers
    E Frizell
    Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA
    Hepatology 21:847-54. 1995
    b>SPARC (secreted protein, acidic and rich in cysteine)--also known as osteonectin, BM-40, and 43K glycoprotein--is secreted by endothelial cells and fibroblasts in response to culture shock...
  22. ncbi SPARC, a matricellular glycoprotein with important biological functions
    Q Yan
    Department of Vascular Biology, Hope Heart Institute, Seattle, Washington 98122, USA
    J Histochem Cytochem 47:1495-506. 1999
    b>SPARC (secreted protein, acidic and rich in cysteine) is a unique matricellular glycoprotein that is expressed by many different types of cells and is associated with development, remodeling, cell turnover, and tissue repair...
  23. ncbi Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma
    A L Lagan
    Clinical Genomics Group, National Heart and Lung Institute and Royal Brompton Hospital, Imperial College, 1B Manresa Road, London SW3 6LR, UK
    Rheumatology (Oxford) 44:197-201. 2005
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell-cell and cell-extracellular matrix interactions...
  24. ncbi SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated
    Cynthia López Haber
    Laboratory of Molecular and Cellular Therapy, Fundación Instituto Leloir CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
    Int J Cancer 122:1465-75. 2008
    ..The secreted protein, acidic and rich in cysteine (SPARC) a component of the ECM, impairs the proliferation of different cell types and modulates tumor cell aggressive ..
  25. pmc Aberrant promoter methylation of SPARC in ovarian cancer
    Matthew J Socha
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neoplasia 11:126-35. 2009
    ..Secreted protein acidic and rich in cysteine (SPARC) is reportedly detrimental to the growth of ovarian cancer cells and has been shown to be epigenetically silenced ..
  26. ncbi SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy
    Kazuhisa Watanabe
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Atheroscler Thromb 16:69-76. 2009
    ..We searched for secretory proteins expressed in a surgical specimen obtained from the eyes of patients with PDR...
  27. pmc Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane
    U M Wewer
    University Institute of Pathological Anatomy, Copenhagen, Denmark
    Am J Pathol 132:345-55. 1988
    The identification and cDNA cloning of bone-enriched osteonectin and parietal endoderm-enriched SPARC indicated that these proteins share greater than 90% homology...
  28. ncbi Osteonectin--a differentiation marker of bone cells
    G Jundt
    Cell Tissue Res 248:409-15. 1987
    ..Osteonectin was absent in all non-skeletal tissues with the exception of chondrocytes in so-called mineralizing chondroid bone...
  29. ncbi Osteonectin, a bone-specific protein linking mineral to collagen
    J D Termine
    Cell 26:99-105. 1981
    ..These studies suggest that osteonectin is a tissue-specific protein, linking the bone mineral and collagen phases, perhaps initiating active mineralization in normal skeletal tissue...
  30. ncbi BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin
    N Hunzelmann
    Department of Dermatology, University of Cologne, Germany
    J Invest Dermatol 110:122-6. 1998
    BM-40 (Osteonectin, SPARC) is the most abundant glycoprotein secreted by human osteoblasts...
  31. ncbi SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    C Kupprion
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    J Biol Chem 273:29635-40. 1998
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and proliferation and is thought to function in tissue remodeling and angiogenesis...
  32. pmc Osteonectin/SPARC secreted by RPE and localized to the outer plexiform layer of the monkey retina
    I R Rodriguez
    National Eye Institute, National Institutes of Health, LRCMB, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 41:2438-44. 2000
    Osteonectin/SPARC is a secreted protein that has been implicated in ocular disease. Deletion of osteonectin/SPARC causes age-onset cataract in mice and the cataractous human lens has increased expression of osteonectin/SPARC...
  33. ncbi The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Obes Res 9:388-93. 2001
    ..In the current study, we have examined the expression of secreted protein, acidic and rich in cysteine (SPARC) in adipose tissue and its significance in obesity and coronary artery disease (CAD).
  34. ncbi SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins
    S A Rempel
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    J Neurooncol 53:149-60. 2001
    We have identified secreted protein acidic and rich in cysteine (SPARC) as a potential glioma invasion-promoting gene...
  35. ncbi Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells
    Richard A Sturm
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:226-32. 2002
    ..Fourteen fragments from known genes including osteonectin (also known as SPARC and BM-40) were identified after three rounds of representational difference analysis...
  36. ncbi MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis
    K Demopoulos
    Department of Virology, Medical School, University of Crete, P O Box 1393, Heraklion, Crete, Greece
    J Cell Mol Med 6:215-22. 2002
    ..3, 3p21.32-p21.1, 5q32-q33.1, 9p21 and 17p13.1 where MYCL1, FHIT, SPARC, p16(Ink4) and TP53 genes have been mapped respectively...
  37. ncbi Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells
    Joseph Briggs
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501, USA
    Oncogene 21:7077-91. 2002
    ..We previously demonstrated that expression of the SPARC/osteonectin gene, while undetectable in the MCF7 cell line, is highly induced in response to stable c-Jun ..
  38. ncbi Localization of SPARC in developing, mature, and chronically injured human allograft kidneys
    Charles E Alpers
    Department of Pathology, University of Washington School of Medicine, Seattle Washington, USA
    Kidney Int 62:2073-86. 2002
    The matricellular protein SPARC (secreted protein acidic and rich in cysteine) is expressed during development, tissue remodeling and repair...
  39. ncbi Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston Medical School, 6431 Fannin, MSB 5 270, Houston, TX 77030, USA
    Arthritis Rheum 46:2990-9. 2002
    ..b>SPARC (secreted protein, acidic and rich in cysteine) regulates the deposition or assembly of ECM components...
  40. pmc SPARC-null mice exhibit increased adiposity without significant differences in overall body weight
    A D Bradshaw
    Department of Vascular Biology, Hope Heart Institute, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 100:6045-50. 2003
    Secreted protein acidic and rich in cysteine/osteonectin/BM-40 (SPARC) is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM)...
  41. ncbi Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients
    Michael I Koukourakis
    Department of Radiotherapy, Democritus University of Thrace, Alexandroupolis 68100, Greece
    Cancer Res 63:5376-80. 2003
    Secreted Protein Acidic and Rich in Cystein (SPARC)/osteonectin is a nonstructural matricellular protein involved in cell-matrix interaction during tissue remodeling and embryonic development...
  42. ncbi Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer
    Sylke Schneider
    Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Cancer Res 10:1588-96. 2004
    ..define the role of osteopontin (OPN) and osteonectin [also known as secreted protein acidic and rich in cysteine (SPARC)] in lung tumorigenesis by comparing the expressions of these genes in lung tumor tissue and matched normal tissue ..
  43. ncbi Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation
    Qing Shi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:52200-9. 2004
    Secreted protein acidic, rich in cysteine (SPARC), is an extracellular matrix protein expressed in many advanced cancers, including malignant gliomas...
  44. ncbi Cellular, but not matrix, immunolocalization of SPARC in the human intervertebral disc: decreasing localization with aging and disc degeneration
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232, USA
    Spine (Phila Pa 1976) 29:2223-8. 2004
    Human intervertebral disc anulus tissue was obtained in a prospective study of immunolocalization of SPARC (secreted protein, acidic and rich in cysteine) (osteonectin)...
  45. pmc Aberrant methylation of SPARC in human lung cancers
    M Suzuki
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Br J Cancer 92:942-8. 2005
    b>SPARC (secreted protein acidic and rich in cysteine) is an extracellular Ca2+-binding matricellular glycoprotein associated with the regulation of cell adhesion and growth...
  46. ncbi Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes
    Gareth Watkins
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Prostaglandins Leukot Essent Fatty Acids 72:267-72. 2005
    b>SPARC (secreted protein acidic and rich in cystein), also known as osteonectin and BM40, is a 32 kDa secreted glycoprotein that interacts with extracellular matrix (ECM) proteins to promote adhesion of cells from the matrix, thereby ..
  47. ncbi Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast
    Peter J Barth
    Institute of Pathology, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Virchows Arch 446:532-6. 2005
    In the present study, we analyzed tumor associated stromal remodeling with special respect to SPARC (secreted protein acid rich in cysteine) expression...
  48. ncbi Roles of osteonectin in the migration of breast cancer cells into bone
    Dianalee A Campo McKnight
    The Pennsylvania State University, Intercollege Degree Program in Physiology, University Park, Pennsylvania 16802, USA
    J Cell Biochem 97:288-302. 2006
    ..We concluded that osteonectin was not a chemotactic factor. However, through its anti-adhesive properties, osteonectin induced undirected breast cancer cell motility, and may have enhanced chemoattraction to vitronectin...
  49. ncbi SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron
    K Li
    Department of Biochemistry and Molecular Biology, Medical School of Shanghai Jiao Tong University, Shanghai 200025, PR China
    Biochem Biophys Res Commun 356:6-12. 2007
    ..One of these was the extra-cellular matrix glycoprotein, SPARC (human secreted protein acidic and rich in cysteine)...
  50. ncbi Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma
    Francisco Javier Rodríguez-Jiménez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Oncol Rep 17:1301-7. 2007
    Secreted protein acidic and rich in cysteine (SPARC) is a secreted matricellular glycoprotein involved in crucial processes that occur during cancer...
  51. ncbi SPARC endogenous level, rather than fibroblast-produced SPARC or stroma reorganization induced by SPARC, is responsible for melanoma cell growth
    Federico Prada
    Laboratory of Molecular and Cellular Therapy, Leloir Institute CONICET University of Buenos Aires, Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina
    J Invest Dermatol 127:2618-28. 2007
    b>SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein whose overexpression in malignant or tumor-stromal cells is often associated with increased aggressiveness and bad prognosis in a wide range of human cancer ..
  52. pmc A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells
    Nanyue Chen
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 67:6544-8. 2007
    ..to identify p45-sErbB3-responsive genes, we found that p45-sErbB3 up-regulated the expression of osteonectin/SPARC, biglycan, and type I collagen in calvaria...
  53. doi A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire
    Clancy J Clark
    Department of General Surgery, Virginia Mason Medical Center, Seattle, Washington 98101, USA
    J Cell Biochem 104:721-32. 2008
    ..Secreted protein acidic and rich in cysteine (SPARC) is a prototypic matricellular protein at the center of this exchange...
  54. pmc SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion
    Christopher K Yunker
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 122:2735-43. 2008
    ..b>SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell ..
  55. pmc IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells
    Jing Nie
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    Stem Cells 26:2735-45. 2008
    ..and cultured human and mouse stromal cells express a conserved receptor targeted by peptides found to mimic SPARC, a matricellular protein that is required for normal WAT development...
  56. ncbi Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma
    Tine S Mantoni
    Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK
    Cancer Biol Ther 7:1806-15. 2008
    ..Pancreatic stellate cells (PSC) drive desmoplasia in pancreatic cancer. Our study analyzed both tumor and PSC, since interaction of these cell types may promote tumor progression...
  57. pmc SPARC ameliorates ovarian cancer-associated inflammation
    Neveen A Said
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Neoplasia 10:1092-104. 2008
    We have recently identified that the role of secreted protein acidic and rich in cysteine (SPARC) in amelioration of peritoneal ovarian carcinomatosis is mediated, at least in part, through mesothelial cell/lysophosphatidic acid-induced ..
  58. pmc Increased SPARC expression in primary angle closure glaucoma iris
    Jocelyn Chua
    Singapore National Eye Centre, Singapore
    Mol Vis 14:1886-92. 2008
    b>SPARC (secreted protein, acidic, and rich in cysteine) is involved in extracellular matrix (ECM) organization...
  59. pmc Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose
    Katrina Kos
    Diabetes and Endocrinology Research Unit, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Diabetes 58:1780-8. 2009
    Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis...
  60. pmc SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
    Wenteh Chang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University Medical Center, Stanford, California 94305 5236, USA
    J Biol Chem 285:8196-206. 2010
    ..We found that IPF fibroblasts constitutively expressed increased basal levels of SPARC, plasminogen activator inhibitor-1 (PAI-1), and active beta-catenin compared with control cells...
  61. doi SPARC: a key player in the pathologies associated with obesity and diabetes
    Katarina Kos
    Department of Diabetes and Vascular Medicine, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK
    Nat Rev Endocrinol 6:225-35. 2010
    b>SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin or BM-40) is a widely expressed profibrotic protein with pleiotropic roles, which have been studied in a variety of conditions...
  62. doi SPARC (osteonectin) in breast tumors of different histologic types and its role in the outcome of invasive ductal carcinoma
    Yi Hsuan Hsiao
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Breast J 16:305-8. 2010
    ..study was to characterize the immunohistochemical distribution of secreted protein acidic and rich in cystein (SPARC) in benign and malignant breast tumors of different histologic types and define its association with the outcome ..
  63. pmc Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells
    P Bhoopathi
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA
    Cell Death Differ 17:1529-39. 2010
    ..Secreted protein, acidic and rich in cysteine (SPARC) is a matrix-associated glycoprotein that influences a variety of cellular activities in vitro and in vivo...
  64. ncbi SPARC mRNA expression as a prognostic marker for pancreatic adenocarcinoma patients
    Kei Miyoshi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Anticancer Res 30:867-71. 2010
    Secreted protein acidic and rich in cysteine (SPARC) is a protein which governs diverse cellular functions and matrix remodeling systems...
  65. pmc Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival
    Jie Yin
    Department of General Surgery, Peking University First Hospital, Beijing, 100034, PR China
    J Exp Clin Cancer Res 29:59. 2010
    Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to tumor development...
  66. doi The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression
    Nina Fenouille
    INSERM, U895, University of Nice Sophia Antipolis, Nice, France
    Pigment Cell Melanoma Res 24:219-32. 2011
    Secreted protein acidic and rich in cysteine (SPARC), or osteonectin, belongs to the family of matricellular proteins that modulate cell-matrix interactions and cellular functions...
  67. doi Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC
    Nina Fenouille
    Universite de Nice Sophia Antipolis, Nice, France
    Cancer Res 70:9659-70. 2010
    b>SPARC is an extracellular matrix protein that exerts pleiotropic effects on extracellular matrix organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer...
  68. ncbi The association between circulating secreted protein acidic and rich in cysteine (SPARC) and glycosylated haemoglobin (HbA(1c)) during lifestyle-modified weight reduction intervention in obese male subjects
    K Kotani
    Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke City, Tochigi, Japan
    J Int Med Res 39:528-32. 2011
    The physiological role and clinical relevance of circulating secreted protein acidic and rich in cysteine (SPARC, or osteonectin) is still poorly understood...
  69. doi SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival
    N Fenouille
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, Biology and Pathologies of Melanocytes, Nice, France
    Oncogene 30:4887-900. 2011
    Aberrant expression of Secreted Protein Acidic and Rich in Cysteine (SPARC)/osteonectin has been associated with an invasive tumor cell phenotype and poor outcome in human melanomas...
  70. doi Elevated plasma levels of SPARC in patients with newly diagnosed type 2 diabetes mellitus
    Dandong Wu
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Road, Yuzhong District, 400010 Chongqing, China
    Eur J Endocrinol 165:597-601. 2011
    Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (..
  71. pmc SPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho-Rac-Cdc42
    Praveen Bhoopathi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:1978-87. 2011
    The matricellular glycoprotein Secreted Protein Acidic and Rich in Cysteine (SPARC) plays an important role in the regulation of cell adhesion and proliferation as well as in tumorigenesis and metastasis...
  72. pmc In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin C
    Li Fong Seet
    Ocular Wound Healing and Therapeutics, Singapore Eye Research Institute, Singapore
    J Cell Mol Med 16:1245-59. 2012
    ..We previously showed that SPARC (secreted protein, acidic, rich in cysteine) knockout mice had improved surgical success in a murine model of GFS...
  73. doi SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/α2β1 integrin axis
    María R Girotti
    Laboratory of Molecular and Cellular Therapy, Fundación Instituto Leloir CONICET, Buenos Aires, Argentina
    J Invest Dermatol 131:2438-47. 2011
    In melanoma, the extracellular protein SPARC (secreted protein acidic and rich in cysteine) is related to tumor progression...
  74. pmc The role of SPARC protein expression in the progress of gastric cancer
    LiFeng Wang
    Department of Pathology, The First Clinical College of Harbin Medical University, Harbin 150001, China
    Pathol Oncol Res 18:697-702. 2012
    We aimed to investigate the expression of SPARC (secreted protein, acidic and rich in cysteine) in gastric cancer and its relationship with tumor angiogenesis and cancer cells proliferation...
  75. pmc Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer
    Jun ling Zhang
    Department of General Surgery, Peking University First Hospital, Beijing, People s Republic of China
    PLoS ONE 7:e44618. 2012
    Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein that functions to inhibit angiogenesis, proliferation, and invasion in different types of cancer...
  76. pmc Loss of SPARC in bladder cancer enhances carcinogenesis and progression
    Neveen Said
    Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 123:751-66. 2013
    Secreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple aspects of human cancer...
  77. pmc Downregulation of SPARC expression inhibits the invasion of human trophoblast cells in vitro
    Yahong Jiang
    NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China
    PLoS ONE 8:e69079. 2013
    ..b>SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that plays critical roles in the ..
  78. doi Clinical significance of SPARC gene expression in patients with gastric cancer
    Tsutomu Sato
    Department of Surgery, Yokohama City University, Yokohama shi, Kanagawa Ken, Japan
    J Surg Oncol 108:364-8. 2013
    Secreted protein acidic and rich in cysteine (SPARC) is one of the first known matricellular proteins that modulates interactions between cells and extracellular matrix...
  79. pmc Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40
    E Hohenester
    Department of Crystallography, Birkbeck College, London, UK
    EMBO J 16:3778-86. 1997
    BM-40 (also known as SPARC or osteonectin) is an anti-adhesive secreted glycoprotein involved in tissue remodelling...
  80. pmc Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens
    M Kantorow
    Department of Biology, West Virginia University, Morgantown, WV 26505, USA
    Mol Vis 6:24-9. 2000
    We have previously reported increased levels of Osteonectin/SPARC transcript in age-related cataractous compared to normal human lenses...
  81. ncbi Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors
    Q Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98122, USA
    Exp Eye Res 71:81-90. 2000
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates morphogenesis, cellular proliferation, and differentiation...
  82. ncbi Enhanced angiogenesis characteristic of SPARC-null mice disappears with age
    May J Reed
    Department of Medicine, The University of Washington, Seattle, WA 98104, USA
    J Cell Physiol 204:800-7. 2005
    ..b>SPARC (secreted protein acidic and rich in cysteine/osteonectin/BM-40) is a matricellular protein that regulates ..
  83. pmc Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma
    Cristiane A Dalla-Torre
    Department of Pediatrics, Instituto de Oncologia Pediátrica IOP GRAACC, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, São Paulo 04023 062, Brazil
    BMC Cancer 6:237. 2006
    ..Identification of the molecular determinants of invasion and metastatic potential may guide the development of a rational strategy for devising specific therapies that target the pathways leading to osteosarcoma...
  84. ncbi Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases
    Q Shi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Oncogene 26:4084-94. 2007
    Secreted protein acidic and rich in cysteine (SPARC) is an extracellular glycoprotein expressed in several solid cancers, including malignant gliomas, upon adoption of metastatic or invasive behaviors...
  85. ncbi Frequent inactivation of SPARC by promoter hypermethylation in colon cancers
    Eungi Yang
    Department of Pathology, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Cancer 121:567-75. 2007
    ..The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and ..
  86. pmc Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis
    A M Delany
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, 06030, USA
    Osteoporos Int 19:969-78. 2008
    Animal models suggest a role for osteonectin/SPARC in determination of bone mass...
  87. doi HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion
    William A Golembieski
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Glia 56:1061-75. 2008
    Secreted protein acidic and rich in cysteine (SPARC) regulates cell-extracellular matrix interactions that influence cell adhesion and migration...
  88. ncbi Expression and clinical significance of SPARC in clinical stage II tongue squamous cell carcinoma
    Jing Zhang
    State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 28:68-71. 2009
    Secreted protein acidic and rich in cysteine (SPARC) is expressed widely in malignant tumors. It is related to prognosis and biological behaviors of tumors...
  89. doi Secreted protein, acidic and rich in cysteine (SPARC) expression in astrocytic tumour cells negatively correlates with proliferation, while vascular SPARC expression is associated with patient survival
    D Capper
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University, Heidelberg, Germany
    Neuropathol Appl Neurobiol 36:183-97. 2010
    Secreted protein, acidic and rich in cysteine (SPARC) is a regulator of cell-matrix interaction and has been associated with tumour stage and patient survival in various malignancies...
  90. doi The impact of the ovarian microenvironment on the anti-tumor effect of SPARC on ovarian cancer
    James B Greenaway
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada
    Biochem Cell Biol 90:96-107. 2012
    A lack of host-derived SPARC promotes disease progression in an intraperitoneal (IP) ID8 mouse model of epithelial ovarian cancer (EOC)...
  91. doi Knockdown of secreted protein acidic and rich in cysteine (SPARC) expression diminishes radiosensitivity of glioma cells
    Haiyan Liu
    School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu Province, China
    Cancer Biother Radiopharm 26:705-15. 2011
    Secreted protein acidic and rich in cysteine (SPARC) has been shown to play an important role in the promotion of glioma...
  92. ncbi Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 32:525-31. 2006
    The matricellular glycoprotein SPARC (secreted protein, acidic and rich in cysteine), also termed osteonectin, has been found to regulate the invasive behaviour of several tumour types by interacting with basement membrane constituents...
  93. ncbi Submicroscopic and immunohistochemical profile of surface osteosarcomas
    A Franchi
    Institute of Anatomic Pathology, University of Florence Medical School, Italy
    Ultrastruct Pathol 23:233-40. 1999
    ..Further, the myofibroblast-like cells that are present in variable numbers in these tumors are probably modified osteoblasts, since they co-express actin, osteonectin, and osteocalcin...
  94. ncbi Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repai
    James Melrose
    Raymond Purves Bone and Joint Research Laboratories, Institute of Bone and Joint Research, University of Sydney, Australia
    Spine (Phila Pa 1976) 27:1756-64. 2002
    ..The spatial and temporal localization of fibroblast growth factor-2, transforming growth factor-beta, osteonectin, and alpha-smooth muscle cell actin in the injured anulus fibrosus was investigated...
  95. pmc The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia
    Anguo Liu
    University of Maryland School of Medicine, Mucosal Biology Research Center, Baltimore, MD 21201, USA
    Microvasc Res 77:13-20. 2009
    ..Three counteradhesive proteins that influence endothelial cell behavior include thrombospondin (TSP)1, (SPARC) (Secreted Protein Acidic and Rich in Cysteine), also known as osteonectin, and tenascin...
  96. ncbi Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis
    A Bini
    Laboratory of Blood Coagulation Biochemistry, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY, USA
    Arterioscler Thromb Vasc Biol 19:1852-61. 1999
    ..These data suggest that the occurrence of T/H might contribute to dystrophic arterial calcification in the progression and complications of atherosclerosis...
  97. pmc Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice
    Luciene Machado do Reis
    University of Sao Paulo, Sao Paulo, Brazil
    Bone 43:264-73. 2008
    ..play a unique role in the skeleton as regulators of bone remodeling, and the matricellular protein osteonectin (SPARC, BM-40) is the most abundant non-collagenous protein in bone...
  98. doi Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia
    Ewa Baumann
    Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Road, Ottawa, Ontario, Canada
    Brain Res 1269:185-97. 2009
    ..In this study, the expression changes of the BM proteoglycan agrin, and the non-structural BM constituent SPARC (BM-40, osteonectin), were studied in brain vessels after global cerebral ischemia...
  99. pmc Characterization of porcine osteonectin extracted from foetal calvariae
    C Domenicucci
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Biochem J 253:139-51. 1988
    ..The chemical and binding properties of porcine osteonectin are closely similar to the recently described 'culture shock', SPARC and BM-40 proteins, indicating that these are homologous proteins.
  100. pmc SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament
    Jessica M Trombetta
    Department of Craniofacial Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Histochem Cytochem 58:871-9. 2010
    Expression of secreted protein acidic and rich in cysteine (SPARC)/osteonectin, a collagen-binding matricellular protein, is frequently associated with tissues with high rates of collagen turnover, such as bone...
  101. ncbi Gene expression and immunohistochemical localization of osteonectin in association with early bone formation in the developing mandible
    Ryo Ishigaki
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    Histochem J 34:57-66. 2002
    ..These results indicate that newly differentiated osteoblasts synthesize and secrete osteonectin, which is mainly incorporated into the mineralized bone matrix and becomes a specific component of developing manibula of foetal rats...

Research Grants64

  1. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..the bone microenvironment is the matricellular glycoprotein osteonectin (secreted protein acidic rich in cysteine, SPARC;BM-40)...
  2. Effect of Osteoporosis on Spine Fusion
    BRIAN CROCKETT COOLEY; Fiscal Year: 2010
    ..Understanding how an osteoporotic predisposition influences spine fusion healing and remodeling is critical for developing better therapeutic options for these patients. ..
  3. AMY DODD BRADSHAW; Fiscal Year: 2015
    ..In the previous funding period, we identified that expression of SPARC (Secreted Protein Acidic and Rich in Cysteine/osteonectin/BM40), a collagen-binding matricellular protein, was ..
  4. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..Functional studies and knock-out mice will be generated for each of these secreted proteins as warranted. ..
  5. AD OC TK/VAL GENE THERAPY CLINICAL CORRELATES
    Leland Chung; Fiscal Year: 2001
    ..abstract_text> ..
  6. EXTRACELLULAR MATRIX PROTEINS IN CELL AND ORGAN CULTURE
    Gloria Gronowicz; Fiscal Year: 1992
    ..Our eventual goal is to learn how to manipulate ECM components to promote normal bone growth and remodeling in vivo for the successful osseointegration of implants, in diseases such as osteoporosis, and traumatic injuries to bone...
  7. Molecular Mechanisms of SPARC Mediated Glioma Invasion
    Jeremy N Rich; Fiscal Year: 2010
    ..Secreted protein, acidic and rich in cysteine (SPARC) - also known as osteonectin - is a protein frequently overexpressed in gliomas at sites of invasion...
  8. Salivary Biomarkers to Predict Alveolar Bone Loss
    Frank Scannapieco; Fiscal Year: 2005
    ..We envision that this approach could be conveniently adapted in the future for use by practicing dentists to provide objective information to assess risk for periodontal bone loss. ..
  9. NUTRITION, GENES AND HIP FRACTURE RISK IN UTAH
    Ronald Munger; Fiscal Year: 2000
    ..The investigators state that the multidisciplinary approach proposed may lead to effective public health interventions to reduce the burden of hip fractures. ..
  10. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2006
    ..receptors, the integrins, and a subset of its ligands, the bone matrix proteins, with an emphasis on osteonectin (SPARC) and a major family of angiogenic growth factors, the VEGFs and its receptors...
  11. DEVELOPMENTAL REGULATION OF MATRIX-MODELING GENES
    Brigid Hogan; Fiscal Year: 1993
    ..transin (stromelysin), and the metalloproteinase inhibitor, TIMP, compared with the Ca++-binding proteins Sparc (osteonectin) and 2ar (osteopontin), b) defining the DNA sequences in the mouse Sparc and rat transin genes which ..
  12. HORMONE REGULATED GENE IN OVARIAN CARCINOGENESIS
    Samuel Mok; Fiscal Year: 1999
    ..However, the role hormone regulated genes in ovarian carcinogenesis has not been extensively studied. SPARC, also termed osteonectin, BM-40, and 43K protein, is an acidic, cysteine-rich component of the extracellular ..
  13. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    ANNE DELANY; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Osteonectin or SPARC (secreted protein acidic and rich in cysteine) is one of the most abundant non-collagenous matrix proteins in bone...
  14. EXTRACELLULAR PROTEINS AS SIGNALS IN ENDOTHELIAL GROWTH
    E Sage; Fiscal Year: 2009
    ..As a founding member of this functional family, SPARC (secreted protein acidic and rich in cysteine;also termed osteonectin and BM-40) inhibits cell adhesion and ..
  15. Role of Osteonectin in Breast Cancer Bone Metastasis
    Jennifer Koblinski; Fiscal Year: 2004
    ..Osteonectin (OSN, SPARC, BM-40) is a bone factor that has been found to be a chemo-attractant for breast and prostrate cancer cells...
  16. Marc B Hershenson; Fiscal Year: 2015
    ..differentiation;and (ii) expression of the matricellular proteins connective tissue growth factor (CTGF), SPARC and periostin predicts BPD development. 2...
  17. Biomaterials for Orbit Reconstruction
    RAJENDRA BHATNAGAR; Fiscal Year: 2001
    ..Such materials can also be useful for repair of bone elsewhere. The overall market value of biomaterials for orthopedic grafts and implants is estimated to be in billions of dollars. ..
  18. The Roles of Osteonectin and Osteoactivin in Gliomas
    Jeremy Rich; Fiscal Year: 2007
    ..2) Validate osteonectin and osteoactivin as potential therapeutic targets in glioma invasion. It is hoped that these studies will provide the basis of novel therapeutic interventions for patients with malignant gliomas. ..
  19. KRISTINA YOLANDA AGUILERA; Fiscal Year: 2015
    ..Collagen expression and deposition is a complex process that is orchestrated in part by the matricellular protein SPARC. Many activities have been ascribed to SPARC although a unifying hypothesis of SPARC function is lacking...
  20. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..Matricellular proteins, and in particular SPARC, generally cause an increase in ECM...
  21. Daniel D Von Hoff; Fiscal Year: 2016
    ..in PDA is a result of the overproduction of extracellular matrix (ECM) proteins such as collagens, hyaluronan, and SPARC (secreted protein acidic and rich in cysteine)...
  22. JESSICA MARIE TROMBETTA-ESILVA; Fiscal Year: 2015
    ..Thus PDL provides an excellent tissue milieu for investigating mechanisms of procollagen processing. SPARC, a collagen-binding protein, has been identified as a key factor in collagen ECM deposition...
  23. CHRISTOPHER SUMEET BABU GONDI; Fiscal Year: 2014
    ..ECM), the levels and deposition of which are controlled in part by secreted protein, acidic and rich in cysteine (SPARC), a matricellular glycoprotein...
  24. David R Sherwood; Fiscal Year: 2015
    ..Finally, we have found that elevated levels of the extracellular matrix protein SPARC, which is overexpressed in most advanced cancer malignancies, decreases type IV collagen levels in basement ..
  25. Cyr61/CCN1-Induced Angiogenesis and Vasculogenesis in the Retina
    Brahim Chaqour; Fiscal Year: 2010
    ....
  26. Brahim Chaqour; Fiscal Year: 2015
    ..This proposal will provide new insights into the molecular mechanisms of CCN1 activities in vivo and may foster future safer, less destructive, and more effective therapies to harness ischemia-induced neovascularization in ROP. ..
  27. Thrombospondins and other matricellular proteins in tissue organization and homeo
    Joanne E Murphy Ullrich; Fiscal Year: 2010
    ..have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, SIBLING, and SPARC families...
  28. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ..proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families...
  29. The role of SPARC in lung fibrosis
    Elizabeth A Putnam; Fiscal Year: 2013
    ..b>SPARC (secreted protein acidic and rich in cysteine) demonstrates reproducibly increased expression in mouse lungs ..
  30. Chuan He; Fiscal Year: 2014
    ..We and others have shown that the matricellular protein Secreted Protein Acidic and Rich in Cysteine (SPARC) regulates the assembly and composition of the extracellular matrix, blocks angiogenesis, and inhibits the growth ..
  31. SANDRA ANN REMPEL; Fiscal Year: 2015
    ..One of the targets we have identified is Secreted Protein Acidic and Rich in Cysteine (SPARC), which is a matricellular protein that is secreted into the extracellular matrix...
  32. Donald M Kuhn; Fiscal Year: 2016
    ....
  33. Regulation of medulloblastoma tumor growth by SPARC
    Sajani Lakka; Fiscal Year: 2012
    ..ECM), the levels and deposition of which are controlled in part by secreted protein, acidic and rich in cysteine (SPARC), a matricellular glycoprotein...
  34. The Role of SPARC during Toxoplasma infection in the Brain
    EMMA HARRIET WILSON; Fiscal Year: 2012
    ..will be conducted looking at a secreted glycoprotein called "secreted protein acidic and rich in cysteine" (SPARC)...
  35. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ....
  36. Structure of sclerostin protein complexes
    Rajiv Kumar; Fiscal Year: 2012
    ..This effort will greatly help women and men with osteoporosis and osteoporosis-related fractures. ..
  37. Comparative effectiveness of noninvasive cardiac imaging
    Marcelo F Di Carli; Fiscal Year: 2010
    ..The Study of Myocardial Perfusion and Coronary Anatomy Imaging Roles in CAD (SPARC) is a prospective, open-label, multicenter, sequentially sampled, observational registry designed to compare SPECT,..
  38. WILLIAM CHRISTOPHER RISHER; Fiscal Year: 2014
    ..of three of these astrocyte-released signals, the matricellular proteins thrombospondin (TSP), hevin and SPARC, to the initial formation and maturation of excitatory synapses...
  39. REGULATION OF VASCULAR GROWTH BY COLLAGEN I AND SPARC
    E Sage; Fiscal Year: 2002
    ..g., collagen) and matricellular proteins (e.g., SPARC, secreted protein acidic and rich in cysteine)...
  40. Matrix and Morphogenesis Conference
    MARION GORDON; Fiscal Year: 2002
    ..Talks will cover the morphogenic roles of fibrillin, SPARC, and individual laminins...
  41. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  42. Measuring Student Exposure to ETS and College Receptivity to Environmental Change
    Mark Wolfson; Fiscal Year: 2009
    ..The trial will build on the success of the approach used in the Study to Prevent Alcohol-Related Consequences (SPARC), a 10-school randomized trial to change the culture and environment on the college campus and surrounding ..
  43. Cagla Eroglu; Fiscal Year: 2016
    ..Astrocytes also express a close homolog of hevin called SPARC. Intriguingly, SPARC is not synaptogenic but specifically inhibits hevin-induced synaptogenesis...
  44. Chuan He; Fiscal Year: 2014
    ..Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular protein that modulates interactions between cells and their environment2,3...
  45. Scan of Protein Space for Optical Voltage Probes
    Lawrence B Cohen; Fiscal Year: 2011
    ..FlaSh), Voltage-Sensitive Fluorescent Protein (VSFP) and Sodium channel Protein Activity Reporting Construct (SPARC)...
  46. REGULATION AND FUNCTION OF SPARC IN MALE REPRODUCTION
    Robert Vernon; Fiscal Year: 1991
    ..A calcium-binding protein, SPARC (Secreted Protein, Acidic and Rich in Cysteine) has been identified in the cytoplasm of a population of murine ..
  47. 300MHZ NMR SPECTROMETER FOR MEDICINAL CHEMISTRY RESEARCH
    VINCENT DAVISSON; Fiscal Year: 1992
    ..broad-band probes and electronics, variable-temperature capability, and an Ethernet link to a SUN Microsystems SPARC workstation (also requested)...
  48. Study to Prevent Alcohol-Related Consequences II
    Mark Wolfson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Study to Prevent Alcohol-Related Consequences (SPARC I) is a five-year NIAAA-funded randomized trial testing a comprehensive intervention using a community organizing approach to implement ..
  49. ENDOGENOUS INHIBITORS OF ADAMS/MDC PROTEINASES
    Jay Fox; Fiscal Year: 2001
    ..Isolation and characterization of these inhibits could therefore be of future importance in developing novel pharmacological agents for the regulation of ADAMs proteins' functions in pathological states. ..
  50. Control of Adipocyte Hypertrophy by Extracellular Matrix
    E Sage; Fiscal Year: 2004
    ..line of ECM structure and composition to compare to two models of adipocyte hypertrophy-- nutritional obesity and SPARC-null mice...
  51. BRAIN ISCHEMIA AND AORTIC ATHEROMATA IN A POPULATION
    GEORGE PETTY; Fiscal Year: 2001
    ..other than stroke or TIA; and 2) 560 randomly selected residents who had a biplane or multiplane TEE for the SPARC study...
  52. The Role of SPARC in Neuroblastoma Angiogenesis
    Susan Cohn; Fiscal Year: 2007
    ..of another Schwann cell-derived secreted inhibitor of angiogenesis, Secreted Protein Acidic and Rich in Cysteine (SPARC)...
  53. CONTROL OF IA ANTIGEN EXPRESSION
    SANTA ONO; Fiscal Year: 1999
    ..1 and its gene will contribute to our understanding of the biology of class II MHC gene regulation, and will form the foundation for future strategies to use NFX.1 in targeted immunomodulation. ..
  54. REGULATION OF FGF 2 MEDIATED ANGIOGENESIS BY SPARC
    Kouros Motamed; Fiscal Year: 2004
    ..in vascular biology, growth factors and their signal transduction, and the extracellular matrix (ECM) protein SPARC (secreted protein acidic and rich in cysteine). The KO1 award will enable Dr...
  55. DISTAL COMPLEMENT COMPONENTS IN IMMUNE RENAL INJURY
    William Couser; Fiscal Year: 2001
    ..expression of cell cycle regulatory proteins (CDK2, CDK4, p21 and p27) and anti-proliferative molecules (TGF-b, SPARC)...
  56. REGULATION OF UROTHELIAL CELL BEHAVIOR BY SPARC
    James Bassuk; Fiscal Year: 2006
    ..Preliminary evidence in our laboratory suggests that Secreted Protein Acidic and Rich in Cysteine (SPARC) plays an important role in regulating DNA synthesis and shape change of urothelial cells, which are two crucial ..
  57. Stretch Regulation and Function of Cyr61 in the Bladder
    Brahim Chaqour; Fiscal Year: 2004
    ..DNA transfection, and DNA-protein interactions will be used to define the transcriptional requirements for Cyr61 gene. Functional alterations of the bladder will be assessed by monitoring the tissue contractility. ..
  58. Transcriptional regulation of CRP1 in smooth muscle
    BRENDA J LILLY; Fiscal Year: 2010
    ..abstract_text> ..
  59. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..abstract_text> ..
  60. High-Throughput Robotic Liquid Handling System
    David Bishop; Fiscal Year: 2003
    ..Capillary Array Sequencer, ABI 3700 Capillary Array Sequencer, Transgenomics WAVE TM fragment analyzer and Sun SPARC system server on our Institutional Ethernet backbone...
  61. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2006
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  62. PROBING CELLULAR FUNCTIONS OF THE MINIBRAIN KINASE
    Yu Wen Hwang; Fiscal Year: 2004
    ..3. To characterize the biochemical properties of dynamin-12 phosphorylated by Mnb kinase. 4. To study the effects of Mnb kinase over-expression on endocytic membrane trafficking. ..
  63. NURSING RESOURCE ALLOCATION/UTILIZATION SYSTEM
    JODY HAGGER; Fiscal Year: 1991
    ..While Sun's Scalable Processor Architecture (SPARC) technology has gained popularity, a significant base for software applications still has not be established...
  64. SPARC--A DIAGNOSTIC MARKER FOR INVASIVE MENINGIOMA
    Sandra Rempel; Fiscal Year: 2000
    ..Consequently, menigioma patients may be either over-or under treated. They have identified SPARC (secreted protein acidic and rich in cysteine) as a gene over-expressed in astrocytic tumors and have observed its ..