SPAG11B

Summary

Gene Symbol: SPAG11B
Description: sperm associated antigen 11B
Alias: EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11, sperm-associated antigen 11B, epididymal protein 2B, human epididymis-specific protein 2, sperm antigen HE2
Species: human

Top Publications

  1. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
  2. pmc Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype
    G Molderings
    , , Germany
    Br J Pharmacol 107:352-5. 1992
  3. pmc Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors
    G J Molderings
    , , Germany
    Br J Pharmacol 111:733-8. 1994
  4. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
  5. doi Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells
    Y Bando
    Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 44:395-401. 2009
  6. ncbi Characterization of chlorinated compounds using a dual chlorine-selective pulsed discharge emission detector-helium-pulsed discharge photoionization detector system
    K Sun
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    J Chromatogr A 872:179-89. 2000
  7. ncbi Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    Y Huang
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:17483-90. 1998
  8. ncbi Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    S Shinomiya
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 61:1153-60. 2001
  9. ncbi Prostaglandin receptors: their role in regulating renal function
    M D Breyer
    Department of Medicine, Department of Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 9:23-9. 2000
  10. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997

Research Grants

  1. CYCLOOXYGENASE AND TUMORIGENESIS
    Daniel Hwang; Fiscal Year: 2003
  2. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
  3. Jianxiong Jiang; Fiscal Year: 2014
  4. SYLVAIN DORE; Fiscal Year: 2014
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
  6. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
  7. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
  8. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
  9. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
  10. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009

Detail Information

Publications250 found, 100 shown here

  1. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
    ..antibodies against HIV-1, we designed two candidate multi-epitope-vaccines, EP1 [C-G-(ELDKWA-GPGRAFY)2-K] and EP2 (CG-GPGRAFY-G-ELDKWA-G-RILAVERYLKD), containing three neutralizing epitopes (GPGRAFY, ELDKWA and RILAVERYLKD) on ..
  2. pmc Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype
    G Molderings
    , , Germany
    Br J Pharmacol 107:352-5. 1992
    ..compounds mimicked the effect of prostaglandin E2 showing the following rank order of potencies: misoprostol (EP2-/EP3-receptor agonist) congruent to sulprostone (EP1-/EP3-receptor agonist) congruent to prostaglandin E1 = ..
  3. pmc Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors
    G J Molderings
    , , Germany
    Br J Pharmacol 111:733-8. 1994
    ..00. These effects were mimicked by prostaglandin E1, the EP1/EP3 receptor agonist, sulprostone and the EP2/EP3 receptor agonist, misoprostol with the rank order (pEC50): sulprostone (8.60) > PGE1 (7...
  4. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
    ..15 +/- 0.03 microM, and a maximum effect ranging from 36-84% (mean inhibition of 68.7 +/- 2.5%, n = 32). 3. The EP2-receptor agonists, misoprostol, 11-deoxy PGE1, AH13205 and butaprost, all at 10 microM, inhibited O2- generation, ..
  5. doi Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells
    Y Bando
    Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 44:395-401. 2009
    Prostaglandin E(2), which exerts its actions via EP receptors (EP1, EP2, EP3 and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase-1 and/or cyclooxygenase-2...
  6. ncbi Characterization of chlorinated compounds using a dual chlorine-selective pulsed discharge emission detector-helium-pulsed discharge photoionization detector system
    K Sun
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    J Chromatogr A 872:179-89. 2000
    ..detector (He-PDPID) is a function of the molecular structure and the number of photoionizable electrons using the He2 band at 13.5-17.5 eV...
  7. ncbi Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    Y Huang
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:17483-90. 1998
    ..effect of apoE2, we bred transgenic mice expressing low levels of apoE2 with LDL receptor-null mice (hE2(+/0), LDLR-/-)...
  8. ncbi Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    S Shinomiya
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 61:1153-60. 2001
    ..Among prostaglandin E (EP) receptor-selective synthetic agonists, EP2 and EP4 agonists caused down-regulation of the zymosan-induced TNFalpha production, but up-regulation on the IL-10 ..
  9. ncbi Prostaglandin receptors: their role in regulating renal function
    M D Breyer
    Department of Medicine, Department of Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 9:23-9. 2000
    ..The FP, TP, and EP1 receptors preferentially couple to increased cell Ca2+. EP2, EP4, DP, and IP receptors stimulate cyclic adenosine monophosphate, whereas the EP3 receptor preferentially ..
  10. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997
    ..PGE2 may interact with at least four receptor subtypes (EP1, EP2, EP3, EP4), each showing different pharmacological profiles...
  11. ncbi [Effects of experimental left varicocele on SPAG11 mRNA and SPAG11E in the testis and epididymis of adolescent rats]
    Hong Tian
    Department of Human Anatomy, Histology and Embryology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Zhonghua Nan Ke Xue 14:200-5. 2008
    To investigate the effects of experimental left varicocele (ELV) on the expression of sperm associated antigen 11 (SPAG11) mRNA and its protein isomer SPAG11E in the testis and epididymis of adolescent rats, and to explore the mechanism ..
  12. pmc Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:271-8. 1992
    ..b>EP2-receptors may be involved in the PGE action, in view of the marked effect of morphine on the contractile actions of ..
  13. ncbi Long-term efficacy of antifungals in toenail onychomycosis: a critical review
    B J Cribier
    Clinique Dermatologique des Hôpitaux Universitaires, 1 place de l Hôpital 67091 Strasbourg, France
    Br J Dermatol 145:446-52. 2001
    ..Modern antifungal drugs achieve high mycological and clinical cure rates in onychomycosis of the toes, but little is known about the long-term evolution of the treated patients...
  14. ncbi Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term
    R Garcia-Villar
    Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    J Soc Gynecol Investig 2:6-12. 1995
    ..in pregnant sheep and baboons in an in vitro superfusion study, and to characterize further the PGE-sensitive (EP) receptor subtype involved in the myometrial response to PGE2 by using the selective prostanoid EP2 agonist AH 13205.
  15. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In wild-type (WT) mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and ..
  16. pmc Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes
    Kai Dallmeier
    University Hospital Freiburg, Freiburg, Germany
    PLoS Pathog 4:e1000230. 2008
    ..chimeric DHBVs with L proteins in which segments 22-90 (Du-He4) or its subsegments 22-37 and 37-90 (Du-He2, Du-He3) are derived from HHBV...
  17. pmc Ontogenic increase in PGE2 and PGF2 alpha receptor density in brain microvessels of pigs
    D Y Li
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 112:59-64. 1994
    ..displaced by AH 6809 (EP1-selective antagonist) by 80-90%, and only by approximately 30-35% by both 11-deoxy PGE1 (EP2/EP3 agonist) and M&B 28,767 (EP3 agonist); butaprost (EP2 agonist) was completely ineffective. 4...
  18. ncbi Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term
    D Wehbrink
    Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Anim Reprod Sci 106:241-54. 2008
    ..In contrast to relaxant prostaglandin E receptor type 2 (EP2), not showing any change in all tissue layers observed, contractile prostaglandin F(2alpha) receptor (FP) was ..
  19. pmc Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation
    K K Meja
    Imperial College School of Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 122:149-57. 1997
    ..4. With respect to PGE2, the EP-receptor agonists, 16,16-dimethyl PGE2 (non-selective), misoprostol (EP2/EP3-selective), 11-deoxy PGE1 (EP2-selective) and butaprost (EP2-selective) were essentially full agonists as ..
  20. ncbi Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene
    T Arakawa
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 271:29569-75. 1996
    ..The levels of the EP2 and EP4 prostaglandin E2 (PGE2) receptors and the prostaglandin I2 receptor were changed in these cells by serum or ..
  21. pmc Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:817-24. 1992
    ..3. Comparison of the jugular vein data with published data for inhibitory agonist potencies on the cat trachea (EP2 preparation) and the field-stimulated guinea-pig vas deferens (EP3) indicates that the EP-receptor in the rabbit ..
  22. pmc Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production
    A O Caggiano
    Committee on Neurobiology, University of Chicago, Illinois 60637, USA
    J Neurochem 72:565-75. 1999
    ..e., EP1, EP2, EP3, and EP4, expression and function in cultured rat microglia...
  23. ncbi Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    Priscilla P Cherian
    Department of Biochemistry and Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:43146-56. 2003
    ..Here we show that fluid flow regulates gap junctions through the PGE2 receptor EP2 activation of cAMP-dependent protein kinase A (PKA) signaling...
  24. pmc Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues
    J S Matthews
    Department of Pharmacology, University of Edinburgh, Scotland
    Br J Pharmacol 108:363-9. 1993
    ..3) suggest the involvement of EP3-receptors as opposed to EP1- or EP2-subtypes. 2...
  25. pmc Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2
    Suresh Yenugu
    Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Reprod Biol Endocrinol 2:61. 2004
    The HE2 gene encodes a group of isoforms with similarities to the antimicrobial beta-defensins...
  26. ncbi Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection
    Katharina Hösl
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Pain 126:46-53. 2006
    ..We have recently identified spinal prostaglandin E receptors of the EP2 subtype (EP2 receptors) and the glycine receptor alpha3 subunit (GlyR alpha3) as signal transduction elements ..
  27. pmc In vitro characterization of prostanoid receptors on human myometrium at term pregnancy
    J Senior
    Postgraduate Studies in Pharmacology, University of Bradford
    Br J Pharmacol 108:501-6. 1993
    ..The EP2/EP3-receptor agonists, rioprostil and misoprostol, produced similar effects to PGE2, however, the excitatory event ..
  28. doi CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid c
    Chandra Prakash
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut, USA
    Drug Metab Dispos 36:2093-103. 2008
    CP-533,536, (3-{[(4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (1), an EP2 receptor-selective prostaglandin E2 agonist, is being developed to aid in the healing of bone fractures...
  29. doi A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells
    Hyunjoo Lee
    Laboratory of B Cell Biology, Karches Center for Chronic Lymphocytic Leukemia Research, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 185:5300-14. 2010
    ..paralleled by a division-related increase in a COX-2-linked enzyme, microsomal PGE(2) synthase-1, and the PGE(2)R, EP2. Cells with the greatest expression of AID expressed the highest levels of EP2...
  30. pmc Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice
    T Minami
    Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan
    Br J Pharmacol 112:735-40. 1994
    ..3. 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone...
  31. ncbi An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women
    N Duckworth
    School of Pharmacy, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
    J Endocrinol 172:263-9. 2002
    ..and the stable thromboxane receptor mimetic, U46619, on human myometrium treated with the prostaglandin E receptor (EP2) agonist, butaprost (selective for the EP2 receptor)...
  32. pmc Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  33. doi PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
    S Otsuka
    Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Osteoarthritis Cartilage 17:529-38. 2009
    The effect of the prostaglandin E2 (PGE2) signal through prostaglandin E receptor 2 (EP2) receptors on the repair of injured articular cartilage was investigated using a selective agonist for EP2.
  34. pmc Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear
    Ryusuke Hori
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    BMC Neurosci 11:35. 2010
    ..of prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) are mediated by the prostaglandin E receptor subtypes EP1, EP2, EP3, and EP4, and the respective agonists have been purified...
  35. ncbi Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
    ..Here we show that homozygous deletion of the gene encoding a cell-surface receptor of PGE(2), EP2, causes decreases in number and size of intestinal polyps in Apc(Delta 716) mice (a mouse model for human familial ..
  36. ncbi Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury
    Peng Zhao
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 27:2357-68. 2007
    ..regulator of PGE2 release, to microglial cells and a neuronal localization of the PGE2 receptor E-prostanoid 2 (EP2)...
  37. doi The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe
    C M Kershaw-Young
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, United Kingdom
    Theriogenology 73:620-8. 2010
    ..05). In conclusion, we inferred that estradiol regulates cervical COX-2 and EP(4) mRNA expression and may regulate cervical relaxation via the synthesis of prostaglandin E(2) and activation of the PGE(2) receptors EP(2) and EP(4)...
  38. ncbi Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents
    Y Naribayashi-Inomoto
    Department of Internal Medicine, Kobe University School of Medicine, Japan
    Gastroenterology 109:341-7. 1995
    ..The aim of this study was to examine the possible presence of PG receptors on the gastric enterochromaffin-like (ECL) carcinoid of Mastomys natalensis, which might be a useful model of normal ECL cells...
  39. doi Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2
    Jacques Q van der Merwe
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 329:747-52. 2009
    ..Immunofluorescence and immunoblot analysis determined that EP2 and EP4 are expressed at the basolateral membrane of SCBN cells...
  40. ncbi Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques
    A Muto
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT, USA
    Int Angiol 29:43-8. 2010
    ..In particular, the PG receptors EP2 and IP stimulate vasodilation and inhibit platelet aggregation, biological processes thought to be protective ..
  41. ncbi A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing
    Mei Li
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut 06340, USA
    J Bone Miner Res 18:2033-42. 2003
    CP-533,536, a newly discovered, non-prostanoid EP2 receptor-selective PGE2 agonist, stimulates local bone formation and enhances fracture healing in rat models.
  42. pmc Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, 35294, USA
    Carcinogenesis 32:86-92. 2011
    ..of these cells, which was associated with a reduction in the levels of COX-2, PGE₂ and PGE₂ receptors (EP2 and EP4)...
  43. ncbi Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes
    Z M Yang
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
    Biol Reprod 56:368-79. 1997
    ..PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4...
  44. ncbi Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
  45. ncbi EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries
    Vikram Jadhav
    Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9629, USA
    J Cereb Blood Flow Metab 24:1305-16. 2004
    ..trinor PGE2 (17-PGE2), sulprostone (EP1/EP3 receptor agonists), and 11-deoxy-16,16-dimethyl PGE2 (11-PGE2, an EP2/EP3-receptor agonist) induced exclusive constriction, which was not affected by endothelium denudation or cold-..
  46. ncbi EP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells
    Gerard Elberg
    Department of Pediatrics, The University of Oklahoma Health Sciences Center, 940 N E 13th St, 2B2309, Oklahoma City, OK 73104, USA
    Am J Physiol Renal Physiol 293:F1622-32. 2007
    ..Biochemical evidence gathered by using real-time RT-PCR mRNA analysis and immunodetection indicate the presence of EP2 receptor in cystic epithelial cells in ADPKD kidney...
  47. ncbi Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis
    Mohamed Alaa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Oncol 34:805-12. 2009
    ..In this study, we examined the correlation between PGE2 receptor 2 (EP2) expression and p16INK4A methylation in NSCLC, and the association with clinicopathological features and prognostic ..
  48. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
    ..To investigate PGE(2)'s roles, the contributions of one of its receptors, EP2, were studied using the mouse skin initiation/promotion model...
  49. ncbi Stimulatory (EP1 and EP3) and inhibitory (EP2) prostaglandin E2 receptors in isolated ileal smooth muscle cells
    A Botella
    Department of Pharmacology, INRA, Toulouse, France
    Eur J Pharmacol 237:131-7. 1993
    ..to study the effect of prostaglandin E2 (PGE2) and three PGE2 receptor (EP) agonists; iloprost (EP1), butaprost (EP2) and enprostil (EP3). In pig cells, PGE2 and enprostil induced cell contraction (22.1 and 21...
  50. pmc Potent contractile actions of prostanoid EP3-receptor agonists on human isolated pulmonary artery
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories
    Br J Pharmacol 113:369-74. 1994
    ..Phenylephrine-induced tone was also inhibited by PGE2 (EC50 = 5-20 nM), 11-deoxy PGE1 and butaprost (a selective EP2-receptor agonist); the latter prostanoids were about 2 and 4 times less potent than PGE2 respectively...
  51. ncbi A novel inhibitory prostanoid receptor in piglet saphenous vein
    R A Coleman
    Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd, Ware, Herts
    Prostaglandins 47:151-68. 1994
    ..The selective synthetic EP-agonists, sulprostone (EP1/EP3) and AH13205X (EP2), were next tested for relaxant activity...
  52. ncbi 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Endocrinology 138:344-50. 1997
    ..uterine actions of PGE2, expression patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2, EP3, and EP4, were investigated in the mouse uterus during pseudopregnancy...
  53. ncbi Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2
    Hiromichi Fujino
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721 0207, USA
    J Biol Chem 277:2614-9. 2002
    ..This is the first indication of a fundamental difference in the signaling potential of EP(2) and EP(4) prostanoid receptors...
  54. ncbi A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:11016-26. 2004
    To assess the structural requirements for G(s) coupling by prostaglandin E receptors (EPs), the G(s)-coupled EP2 and G(i)-coupled EP3beta receptors were used to generate hybrid receptors...
  55. ncbi Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Exp Ther 304:1055-62. 2003
    ..Although neither butaprost (EP2), ONO-NT-012 (EP3), nor 11-deoxy PGE1 (EP4) alone had any effect on HCl/ethanol-induced gastric lesions, only ..
  56. ncbi Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
    ..However, following challenge with the fibrogenic agent, bleomycin, fibroblasts showed loss of EP2 expression...
  57. doi In vivo intra-luteal implants of prostaglandin (PG) E1 or E2 (PGE1, PGE2) prevent luteolysis in cows. II: mRNA for PGF2α, EP1, EP2, EP3 (A-D), EP3A, EP3B, EP3C, EP3D, and EP4 prostanoid receptors in luteal tissue
    Yoshie S Weems
    Department of HNFAS, University of Hawaii, Honolulu, USA
    Prostaglandins Other Lipid Mediat 97:60-5. 2012
    ..Corpora lutea slices were analyzed for mRNA for prostanoid receptors (FP, EP1, EP2, EP3 (A-D), EP3A, EP3B, EP3C, EP3D, and EP4) by RT-PCR...
  58. doi Microwave spectroscopy of the seeded binary and ternary clusters CO-(pH2)2, CO-pH2-He, CO-HD, and CO-(oD2)N=1,2
    Paul L Raston
    Department of Chemistry, University of Adelaide, SA 5005, Australia
    J Chem Phys 142:144308. 2015
    ..The a-type frequency of CO-pH2-He is similar to that of CO-He2 [Surin et al., Phys. Rev. Lett...
  59. doi Producing and imaging a thin line of He2 (∗) molecular tracers in helium-4
    J Gao
    Mechanical Engineering Department, Florida State University, Tallahassee, Florida 32310, USA
    Rev Sci Instrum 86:093904. 2015
    ..instrumentation for flow-visualization in helium based on the generation and imaging of thin lines of metastable He2 (∗) tracer molecules...
  60. pmc A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2
    H Giles
    Analytical Pharmacology Group, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 104:541-9. 1991
    ..tissues; the lack of selective antagonists for each receptor means that conclusions regarding efficacy at FP and EP2 receptors must remain provisional. 2...
  61. ncbi Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, England
    J Pharmacol Exp Ther 268:1526-31. 1994
    ..Misoprostol, which is selective for both EP2- and EP3-receptors, inhibited the edema response to ZAS (> 40%) but had no effect on the response to PAF...
  62. ncbi Prostaglandin receptors in the kidney: a new route for intervention?
    M D Breyer
    Department of Veterans Affairs Medical Center and Vanderbilt University, Department of Medicine, Nashville, Tenn 37232, USA
    Exp Nephrol 6:180-8. 1998
    ..preferentially couples to a different signal transduction pathway, including stimulation of cAMP generation by the EP2 and EP4 receptors; inhibition of cAMP generation, via Gi by EP3 receptors, and activation of phosphatidylinositol ..
  63. ncbi Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
    F Ushikubi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 395:281-4. 1998
    ..PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Here we generate mice lacking each of these receptors by homologous recombination...
  64. ncbi Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype
    S L Smock
    Department of Cardiovascular and Metabolic Diseases, Central Research Division, Pfizer, Inc, Eastern Point Road, Groton, CT, USA
    Gene 237:393-402. 1999
    Northern blot analysis of human placental RNA using a probe to the 5' end of the human prostaglandin E(2) (PGE(2)) EP2 receptor subtype coding region revealed the existence of a high abundance, low molecular weight transcript...
  65. pmc Characterization of the prostanoid receptor types involved in mediating calcitonin gene-related peptide release from cultured rat trigeminal neurones
    D W Jenkins
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Cambridge, CB2 1QJ
    Br J Pharmacol 134:1296-302. 2001
    ..3. Increases in CGRP levels were also observed in response to prostaglandin D2 (PGD2), and the EP2 receptor selective agonist, butaprost...
  66. ncbi Myometrial maturation and labour
    L Carbillon
    Department of Obstetrics and Gynecology, Hopital Jean Verdier, Bondy, France
    Ann Med 33:571-8. 2001
    ..However, the decrease in prostaglandin E2 receptor subtype EP2 on one hand and the down-regulation of the nitric oxide (NO) pathway and various vasorelaxing peptides on the other ..
  67. ncbi Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 287:F1269-82. 2004
    ..The subtype of PGE receptors involved, EP2 and/or EP4, was studied by immunohistochemistry and renal pelvic administration of agonists and antagonists of EP2 ..
  68. ncbi SPAG11/isoform HE2C, an atypical anionic beta-defensin-like peptide
    Hans Henning von Horsten
    IHF Institute for Hormone and Fertility Research at the University of Hamburg, Hamburg, Germany
    Peptides 25:1223-33. 2004
    A human caput epididymidal cDNA, HE2C, was cloned based on its homology to the known chimpanzee counterpart, suggesting that the encoded beta-defensin-like peptide represented a conserved component of the innate epididymidal epithelial ..
  69. ncbi Functional pharmacology of human prostanoid EP2 and EP4 receptors
    Richard J Wilson
    Receptor Pharmacology Unit, Department of In Vitro Pharmacology, GlaxoSmithKline Medicines Research Center, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
    Eur J Pharmacol 501:49-58. 2004
    ..Key differentiating agonists are: butaprost FA, 16,16-dimethyl-prostaglandin E(2), 19-(R)-hydroxy prostaglandin E(2), misoprostol, BW245C, prostaglandin F(2alpha) and prostaglandin D(2)...
  70. ncbi Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2
    Elena Sokolova
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Am J Physiol Lung Cell Mol Physiol 288:L793-802. 2005
    ..The effect of PGE(2) was continuously growing with time. Furthermore, PGE(2) exerts its effect through the EP2 receptor that was confirmed using the selective EP2 agonist butaprost...
  71. ncbi Shape resonances as poles of the semiclassical Green's function obtained from path-integral theory: application to the autodissociation of the He2++ 1sigma(g)+ state
    Cleanthes A Nicolaides
    Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vasileos Constantinou Avenue, Athens, 16135 Greece
    J Chem Phys 123:24309. 2005
    ..A brief presentation is also given of the quantal methods (and their results) that were applied previously for these shape resonances, such as the amplitude, the exterior complex scaling, and the lifetime matrix methods...
  72. ncbi Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
    Xibin Liang
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:10180-7. 2005
    ..Recent studies implicate the prostaglandin E2 (PGE2) E prostanoid subtype 2 (EP2) receptor in the development of the innate immune response in brain...
  73. ncbi Decreased prostaglandin E2 production by inflammatory cytokine and lower expression of EP2 receptor result in increased collagen synthesis in keloid fibroblasts
    Toshihiko Hayashi
    Department of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Invest Dermatol 126:990-7. 2006
    ..These findings may aid in the development of a therapeutic strategy for the regulation of collagen synthesis in keloid fibroblasts...
  74. ncbi Bidirectional trafficking of prostaglandin E2 receptors involved in long-term potentiation in visual cortex
    Yukio Akaneya
    Solution Oriented Research for Science and Technology Program, Japan Science and Technology Agency, Suita 565 0871, Japan
    J Neurosci 26:10209-21. 2006
    ..RNA interference (RNAi) for PGE2 receptor subtypes EP2 and EP3, which are known to upregulate and downregulate the level of cAMP, respectively, induced significant ..
  75. pmc Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Cancer Res 67:2015-21. 2007
    ..Following UVB exposure, protein levels of EP1, EP2, and EP4 were elevated in WT mice, but EP2 and EP4 levels were 50% lower in COX-2-/- mice...
  76. ncbi The effect of extended grazing time and supplementary forage on the dry matter intake and foraging behaviour of cattle kept under traditional african grazing systems
    D G Smith
    Department of Agriculture and Forestry, University of Aberdeen, Aberdeen, Scotland, UK
    Trop Anim Health Prod 38:75-84. 2006
    ..Live weight gain, DMI and foraging behaviour were measured during the late dry season (EP1) and the wet season (EP2). None of the treatments had any significant effect on either DMI or LWG during EP1 or EP2...
  77. ncbi Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease
    W Todd Penberthy
    University of Cincinnati, Cincinnati, OH 45237, USA
    Curr Drug Metab 8:245-66. 2007
    ..exert potent anti-inflammatory activities through endogenous signaling mechanisms involving the GPCRs EP2, EP4, and DP1 along with PPARgamma respectively...
  78. pmc Prostaglandin E(2) receptors in bone formation
    M Li
    Pfizer Global Research and Development, Groton Laboratories, Mail Stop 8118W 208, Groton, CT, 06340, USA
    Int Orthop 31:767-72. 2007
    ..Recent studies have shown that EP2 and EP4 receptors play important roles in regulating bone formation and resorption...
  79. ncbi Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors
    Ryo Hatazawa
    Dept of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical Univ, Misasagi, Yamashina, Kyoto 607, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G788-97. 2007
    ..reversed by the coadministration of 11-deoxy-PGE1 (EP3/EP4 agonist) but not other prostanoids, including the EP1, EP2, and EP3 agonists...
  80. ncbi The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Asia Pac J Clin Nutr 17:204-7. 2008
    ..this study, we found that ET-18-O-CH3 treatment resulted in elevated mRNA expression of the PGE2 receptor subunit, EP2 receptor...
  81. ncbi Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS
    Sonemany Salinthone
    Portland Veterans Affairs Medical Center, VAMC RD 8, 3710 Portland, OR 97239, USA
    Endocr Metab Immune Disord Drug Targets 8:132-42. 2008
    ..In addition, LA activates the prostaglandin EP2 and EP4 receptors to stimulate the production of the small molecule cyclic adenosine 5' monophosphate (cAMP)...
  82. pmc Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death
    Minjian Chen
    Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 205:2791-801. 2008
    ..PGE(2) acts by engaging the PGE(2) receptor EP2, which induces cyclic AMP production and protein kinase A activation...
  83. doi Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth
    Yasuhumi Ogawa
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Biochem Biophys Res Commun 382:720-5. 2009
    ..in WT mice transplanted with BMCs from EP3(-/-) mice, but not in mice transplanted with BMCs from either EP1(-/-), EP2(-/-), or EP4(-/-) mice...
  84. pmc Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA
    Fumiaki Kojima
    Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Kentucky Clinic, Lexington, KY 40536 0284, USA
    Prostaglandins Other Lipid Mediat 89:26-33. 2009
    ..The effect of PGE(2) was mimicked by an EP2 receptor agonist, an EP4 agonist and a cAMP-elevating agent forskolin with association to the increase of cAMP, but ..
  85. pmc Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation
    Anders Lundequist
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:433-41. 2010
    ..of the stable PGE(2) analog 16, 16-dimethyl PGE(2), or of selective agonists of the E-prostanoid (EP) 1, EP2, and EP3 receptors, respectively, for PGE(2)...
  86. doi Expression of prostaglandin E₂ receptor subtypes in the canine lower urinary tract varies according to the gonadal status and gender
    S Ponglowhapan
    Department of Obstetrics, Gynaecology and Reproduction, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330 Thailand
    Theriogenology 74:1450-66. 2010
    ..Expression for EP1, EP2, EP3, and EP4 and their mRNA (EP2, EP3, and EP4) was investigated...
  87. pmc Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2
    Jianxiong Jiang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 109:3149-54. 2012
    ..Activation of prostaglandin E2 receptor (PGE(2)) subtype EP2 promotes inflammation and is just beginning to be explored as a therapeutic target...
  88. pmc Role of PGE2 in asthma and nonasthmatic eosinophilic bronchitis
    Beatriz Sastre
    Immunology Department, IIS Fundación Jiménez Díaz and CIBER of Respiratory Diseases, 28040 Madrid, Spain
    Mediators Inflamm 2012:645383. 2012
    ..sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity...
  89. ncbi Potential therapeutic interventions via EP2/EP4 prostaglandin receptors
    Michał Zimecki
    Department of Experimental Therapy, The Institute of Immunology and Experimental Therapy, Wrocław, Poland mail
    Postepy Hig Med Dosw (Online) 66:287-94. 2012
    ..This article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility.
  90. pmc Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells
    Evangelia Pantazaka
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Br J Pharmacol 169:1624-34. 2013
    ..Histamine and prostaglandin E2 (PGE2 ), directly and via their effects on other cells, regulate the behaviour of vascular smooth muscle (VSM), but their effects on human VSM are incompletely resolved...
  91. pmc Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production
    Jason Hellmann
    Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 191:1383-92. 2013
    ..Macrophages isolated from obese-diabetic mice expressed prostanoid receptors, EP2 and DP1, and contained significantly higher levels of downstream effector, cAMP, compared with wild-type mice...
  92. doi Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways
    Seon Min Woo
    Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea
    Mol Carcinog 54:216-28. 2015
    ..Inhibitor of Src (Saracatinib) markedly reduced PGE2 -mediated migration. We found that EP2, a PGE2 receptor, is involved in PGE2 -mediated cell migration...
  93. pmc The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors
    Kamal Srivastava
    Pediatric Allergy and Immunology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574
    Am J Physiol Lung Cell Mol Physiol 305:L1002-10. 2013
    ..The effect of cyclooxygenase inhibition and EP2/EP4 receptor blockade on ASHMI attenuation of acetylcholine contractions was evaluated...
  94. doi EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium
    Mandeep K Kandola
    Parturition Research M K K, L S, Y S L, M R J, P R B and G Protein Coupled Receptor GPCR Signaling Groups A C H, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 155:605-17. 2014
    ..Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence...
  95. doi EP2 signaling mediates suppressive effects of celecoxib on androgen receptor expression and cell proliferation in prostate cancer
    E Kashiwagi
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Prostate Cancer Prostatic Dis 17:10-7. 2014
    ..However, the mechanisms involved remain unclear. In this study, we investigated the suppression of prostate cancer growth by celecoxib and elucidated the biological relevance of the inhibited pathway in prostate cancer cell lines...
  96. ncbi Gastric cytoprotection by prostaglandin E₂ and prostacyclin: relationship to EP1 and IP receptors
    K Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Kyoto, Japan
    J Physiol Pharmacol 65:3-14. 2014
    ..EP1), stimulation of mucus secretion (EP4) and HCO₃⁻ secretion (EP1), and an increase in mucosal blood flow (EP2/EP4)...
  97. pmc Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB
    Amrita Ahluwalia
    Medical and Research Services, Veterans Affairs Long Beach Healthcare System VALBHS, Long Beach, California, and the Department of Medicine Gastroenterology, University of California, Irvine, California
    Am J Physiol Gastrointest Liver Physiol 307:G602-10. 2014
    ..Using an esophageal ulcer model in rats, we demonstrated that esophageal mucosa expresses predominantly EP2 receptors and that esophageal ulceration triggers an increase in expression of the EP2 receptor, activation of CREB ..
  98. doi Therapeutic angiogenesis by autologous adipose-derived regenerative cells: comparison with bone marrow mononuclear cells
    Changning Hao
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Am J Physiol Heart Circ Physiol 307:H869-79. 2014
    ..In mice studies, we presented that ADRCs polarized into the IL-10-releasing M2 macrophages through PGE2-EP2/4 axis and suppressed the expressions of TNF-α and IL-6 in the ischemic muscle...
  99. pmc PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts
    Kamal M Kassem
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, United States
    Prostaglandins Other Lipid Mediat 113:62-8. 2014
    ..Treatment of NVFs with PGE2 reduced the number of cells migrating toward 10% FCS. Treatment with the EP2 agonist also reduced migration but did not affect MMP-14 expression or PAI-1...
  100. doi Dynamic changes in the spatio-temporal expression of the β-defensin SPAG11C in the developing rat epididymis and its regulation by androgens
    Camilla M Ribeiro
    Section of Experimental Endocrinology, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP 04044 020, Brazil
    Mol Cell Endocrinol 404:141-50. 2015
    ..cellular distribution and regulation by androgens of the β-defensin SPAG11C, the rat ortholog of the human SPAG11B isoform C, in the developing epididymis by using RT-PCR, in situ hybridization and immunohistochemistry...
  101. pmc EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation
    Ting Zhang
    Department of Neurobiology, Capital Medical University, Beijing Institute for Brain Disorders and Key Laboratory for Neurodegenerative Disorder, Ministry of Education, No 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, China
    J Neuroinflammation 12:50. 2015
    ..The present study explored potential signal pathways of triptolide in the lipopolysaccharide (LPS)-induced inflammatory response using primary rat microglial cells...

Research Grants64

  1. CYCLOOXYGENASE AND TUMORIGENESIS
    Daniel Hwang; Fiscal Year: 2003
    ..cells as compared with normal cells and to identify downstream signaling pathways of prostaglandin E receptor (Ep2)...
  2. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
    ..the influence of IL-1a on cell and tissue responses to PGE2, initially focusing on regulation and actions of the EP2 subtype of PGE2 receptor...
  3. Jianxiong Jiang; Fiscal Year: 2014
    ..pursued two major avenues of research 1) to develop small molecules that selectively modify prostaglandin receptor EP2, and 2) to determine how these compounds affect the pathologies in mouse models of epilepsy...
  4. SYLVAIN DORE; Fiscal Year: 2014
    ..our current working hypothesis is that PGE2 EP1 and EP3 receptors would promote ICH acute injury, whereas EP2 and EP4 receptors would promote neuroprotection after ICH...
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..balance in BO development following second hit (ischemic, viral) injury, use genetic (COX, prostanoid receptor [EP2], and 5-LO deficient) and pharmacologic (COX and 5-LO inhibitor, LT receptor antagonist) strategies...
  6. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
    ..leukocyte infiltration, microglial activation, and eventually epilepsy;and (2) To test the hypothesis that EP2 receptor activation on astrocytes or endothelial cells regulates albumin leakage and leukocyte infiltration across ..
  7. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..1 [BLT1]) and LTD4 (via cysteinyl LT receptor 1 [cysLT1]) promote, while PGE2 (via E prostanoid receptors 2 and 4 [EP2 and EP4]) inhibits, AM capacity for phagocytosis and killing of IgG-opsonized microbes...
  8. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..In recent studies, we have identified a central function of PGE2 signaling through its EP2 receptor in mediating inflammation, oxidative stress, and neurotoxicity...
  9. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ..The major prostaglandin (PG) product, PGE2, binds to one or more of the 4 EP receptors. EP2 and EP4 are linked to adenylate cyclase causing an increase in cAMP and subsequent activation of protein kinase A (..
  10. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..We hypothesize that long chain, prostaglandin-like oxPL induce PAFAH by binding to the CD14/ TLR4 complex and the EP2 prostaglandin receptor on dendritic cells in the developing atherosclerotic lesion...
  11. Cellular and Molecular Mechanisms of Inflammation in Alzheimer's Disease
    Nathaniel S Woodling; Fiscal Year: 2012
    ..Downstream of prostaglandin production, the PGE2 EP2 receptor may be a more specific molecular target in the search for strategies that prevent and reduce inflammation ..
  12. Role of COX-2 in UVB-induced beta-catenin signaling in keratinocytes
    Jill C Pelling; Fiscal Year: 2011
    ..primary mouse and human keratinocytes, as well as in mouse epidermis in vivo using COX-2+/- heterozygote mice and EP2-/- knockout mice and in human skin tumor samples...
  13. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..1) to study mRNA and protein expression and localization for contractile FPI, EP1, EP3, and TP and relaxatory IP, EP2, and EP4 receptors in pregnant rat myometrium (day 16 to one day postpartum) and in pregnant animals with hormonal ..
  14. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
    ..PGE2 binds to one of four G-protein linked receptors designated EP1, EP2, EP3, and EP4...
  15. CYCLOOXYGENASE AND PGE2 RECEPTOR FUNCTION IN SKIN CANCER
    Alice Pentland; Fiscal Year: 2004
    ..Our preliminary work demonstrates that primary human keratinocytes express both growth-stipulatory (EP2) and growth- inhibitory (EP3) receptors for prostaglandin E2 (PGE2) in significant amounts...
  16. MOLECULAR BASIS OF PRECONDITIONING
    Yiru Guo; Fiscal Year: 2005
    ..will be systematically interrogated by targeted genetic disruption of all known prostaglandin receptors (DP, EP1, EP2, EP3, EP4, F, and IP receptors)...
  17. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..the production of the small second molecule messenger cAMP via the prostaglandin G-coupled protein receptors EP2 and EP4...
  18. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..using the urethane-induced mouse lung cancer model with or without expression of EP receptor, particularly EP2 and EP4 receptors, will be further studied...
  19. PROSTANOIDS IN COLON CANCER--CELL/MOLECULAR MECHANISMS
    James Roche; Fiscal Year: 1999
    ..now allow these issues to be addressed: 1) Procurement of sequence information/cloning of receptors for prostanoids EP2, EP3, EP4, IP, FP and TP; 2) A cDNA clone for a second (inducible) cyclo- oxygenase with potential importance in ..
  20. Paul J Grippo; Fiscal Year: 2016
    ..and during disease progression along with specific molecular events (activation of Akt, effects of PGE3-bound EP2 on Akt activation, phosphorylation of various proteins like Akt, Foxo, and Bad,) will determine the mechanisms of ..
  21. HSCT-induced changes that impair lung innate immunity
    Bethany B Moore; Fiscal Year: 2012
    ..AMs from human HSCT patients overexpress COX-2 and PGE2 and have altered scavenger receptor profiles, the mechanisms by which this occurs and to test the therapeutic effect of cyclooxygenase or EP2 inhibition on innate immune function.
  22. Chung Owyang; Fiscal Year: 2016
    ..these abnormalities may be prevented by blockade of Toll-like receptor 4 signaling pathway or administration of EP2 receptor inhibitor, suggesting medication by prostaglandin evoked by LPS...
  23. Mechanisms for Dysfunctional HDL Formation in Familial Hypercholesterolemia
    Macrae F Linton; Fiscal Year: 2013
    ..receptors implicated in atherogenesis, including receptors for thromboxane (TP) and prostaglandin (PG)E2 (EP2)...
  24. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..PGE2 produced at the site of inflammation acts on the nociceptors of peripheral terminals through EP1, EP2, EP3, and EP4 receptors by integrating multiple cell signaling pathways...
  25. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..The cellular effects of PGE are receptor mediated and four PGE receptors (EP) have been identified and termed EP 1, EP2, EP3, and EP4...
  26. EP2 Allosteric Potentiators for Subarachnoid Hemorrhage
    Raymond J Dingledine; Fiscal Year: 2012
    ..b>EP2 receptor activation has been shown to be neuroprotective in several animal models of acute cerebral ischemia...
  27. Development of a Novel Atmospheric Pressure Glow Discharge for Ambient Mass Spect
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2011
    ..Optical spectroscopy measurement revealed novel species (He2+), which are implicated in the ionization mechanism...
  28. TANYA MARIA LAIDLAW; Fiscal Year: 2016
    ..that platelets from individuals with AERD demonstrate decreased function of two prostaglandin E2 receptors, EP2 and EP4, which lowers the threshold for activation of their platelets and allows for increased platelet adhesion ..
  29. SURAJ SUNIL PRADHAN; Fiscal Year: 2014
    ..prostaglandin E2 (PGE2) can regulate innate immune responses in the brain via the pro- inflammatory receptor EP2 and anti-inflammatory receptor EP4...
  30. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
    ..e., degranulation)). These limitations have led us to create an allergen- naive double transgenic mouse (I5/hE2) that expresses IL-5 systemically from mature T cells and eotaxin-2 locally from lung epithelial cells...
  31. Molecular Basis of Treating Endometriosis by Prostaglandin E2 Receptor Inhibitors
    Joe A Arosh; Fiscal Year: 2012
    ..Our central hypothesis is that loss-of-function of PGE2 receptors EP2 and EP4 inhibits survival and growth of endometriosis...
  32. Development of a Novel Atmospheric Pressure Glow Discharge for Ambient Mass Spect
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2012
    ..Optical spectroscopy measurement revealed novel species (He2+), which are implicated in the ionization mechanism...
  33. E-Prostanoid Receptor Subtype 2 (EP2) Regulation of Microglial Activation
    Patrick J Cimino; Fiscal Year: 2011
    ..Recently we demonstrated that genetic ablation of the EP2 receptor from primary mouse microglia resulted in the highly desirable dual phenotype of an increase in ..
  34. Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Lung Fibroblasts
    Steven K Huang; Fiscal Year: 2013
    ..What is unclear is how EP2 expression is lost in these cells...
  35. Richard M Breyer; Fiscal Year: 2014
    ..Our working hypothesis is that blockade of both the EP1 and EP3 receptors while leaving the EP2 and EP4 receptor response intact will be protective in settings of renal disease and may be more beneficial than ..
  36. Vassiliki A Boussiotis; Fiscal Year: 2016
    ..In UCB T cells PGE2 modified the Wnt signaling cascade through EP2/EP4 receptors and cAMP-mediated phosphorylation of Gsk3, resulting in stabilization of [unreadable]-catenin and TCF-..
  37. PG's and Keratinocyte Adhesion
    Sabine M Brouxhon; Fiscal Year: 2013
    ..Moreover, the candidate has discovered that this process is regulated by activation of the EP2 receptor by PGE2 released locally after UV radiation injury...
  38. Joshua A Boyce; Fiscal Year: 2016
    ..These abnormalities result in failure of the prostaglandin (PG)E2-EP2 receptor system to control the synthesis and effector actions of cysteinyl leukotrienes (cys-LTs)...
  39. The role of E-cadherin in photocarcinogenesis
    Sabine M Brouxhon; Fiscal Year: 2010
    ..since we recently demonstrated that inhibition of PGE2 synthesis by indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo or in vitro abrogated this UV-..
  40. Role of PGE2 receptors in the aging brain after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2012
    ..We hypothesize that PGE2 EP1 and EPS receptors promote acute brain injury, whereas EP2 and EP4 receptors promote neuroprotection after ICH. Three specific aims will test our hypothesis...
  41. ELAINE EMILY WIRRIG; Fiscal Year: 2014
    ..In bone, COX2 catalyzes the first committed step in the synthesis of prostaglandin E2, which signals via the EP2 receptor to phosphorylate p-38 MAPK, which subsequently activates an osteogenic pathway necessary for new bone ..
  42. Raymond J Dingledine; Fiscal Year: 2015
    ..We have evidence that activation of brain EP2 receptors can be neuroprotective after status epilepticus...
  43. Joshua A Boyce; Fiscal Year: 2016
    ..We have also found that platelets and leukocytes from individuals with AERD lack the EP2 receptor for PGE2...
  44. Molecular Mechanism of PGE2 Receptor Pressor Effects
    Richard M Breyer; Fiscal Year: 2011
    ..The EP1 and EP3 receptors primarily mediate the pressor response, while the EP2 and EP4 receptors mediate the depressor response...
  45. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..Our specific aims are: 1) To synthesizL he2' 'At-labeled octreotide analogues [N-(3-[211 At]astatobenzoyl)-D-phe1]octreotide and 5[211 'At]astato-nicotinoylD-..
  46. PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Courtney Houchen; Fiscal Year: 2006
    ..The EP receptors are encoded by four separate genes (EP1, EP2, EP3 and EP4). These receptors differ in their ligand binding specificity and in down stream signaling pathways...
  47. Adenylyl cyclases in airway and GI smooth muscle
    Rennolds S Ostrom; Fiscal Year: 2010
    ..cAMP formation and relaxation but not increased basal cAMP levels or response to activation of prostaglandin EP2 receptors...
  48. ROLE OF PGE2 RECEPTORS EP2 AND EP3 ON SENESCENCE
    Raymond Konger; Fiscal Year: 2004
    Growth stimulation by EP2 receptors is dependent on ligand- dependent activation of adenylate cyclase, with elevation of cyclic adenosine monophosphate (cAMP)...
  49. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2004
    ..with PLE like elements and this investigator demonstrated the functionality of the PLE in the gene encoding the HIV-EP2/Schnurri 2, a zinc finger transcription factor that activates transcription of the integrated HIV-1 provirus...
  50. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We will test the hypothesis that PGE2 acts via EP1 and EP2 receptor subtypes to stimulate both PKC and PKA pathways, which induce P450arom expression...
  51. PGE2 in the Pathogenesis of Allergic Airway Disease
    Beverly Koller; Fiscal Year: 2009
    ..we showed that activation of the EP1 and EP3 receptors by PGE2 leads to airway obstruction, while activation of the EP2 receptor protected against methacholine-induced bronchoconstriction...
  52. Genetic Study of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Cornelia Ulrich; Fiscal Year: 2007
    ..PGES) and 15- hydroxyprostaglandin dehydrogenase (PGDN); b) bind to PGE2 at the cell surface (receptors EP1, EP2, and EP4); or c) are involved in PGE2 cross-talk with EGFR signaling (Src and EGFR)...
  53. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
    ..have developed data suggesting that the effects of PGE2 on these events in mice are mediated through binding to the EP2 receptor...
  54. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..of this study is that endogenous PGE2 increases the sensitivity of the pulmonary C-fiber endings by activating EP2 and/or EP4 prostanoid receptors; activation of these EP receptors enhances the neuronal excitability by activating ..
  55. Modulation of Lung Innate Immunity Prostaglandin E2
    David Aronoff; Fiscal Year: 2009
    ..effects changes in cell functions through ligation of four distinct G-protein coupled E-prostanoid receptors (EP1, EP2, EP3 and EP4)...
  56. PROSTAGLANDIN E2 RECEPTORS IN GASTROINTESTINAL INJURY
    Courtney Houchen; Fiscal Year: 2004
    ..The EP receptors are encoded by four separate genes (EPI, EP2, EP3, and EP4 )...
  57. Functional Analysis of the Prostaglandin EP3 Receptor
    Richard Breyer; Fiscal Year: 2005
    ..of PGE2's effects are mediated via specific guanine nucleotide regulatory protein coupled receptors designated EP1, EP2, EP3, and EP4...
  58. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  59. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  61. ROLE OF PROTEIN KINASES IN TRANSPORT REGULATION
    Mary Taub; Fiscal Year: 2004
    ..The possible involvement of an inhibitory phosphatase, in regulating the phosphorylation of the Na,K-ATPase will also be examined. ..
  62. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  63. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..