SOCS6

Summary

Gene Symbol: SOCS6
Description: suppressor of cytokine signaling 6
Alias: CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6, STAT induced STAT inhibitor-4, cytokine-inducible SH2 protein 4, suppressor of cytokine signaling 4
Species: human

Top Publications

  1. ncbi Cloning and characterization of novel CIS family genes
    M Masuhara
    Institute of Life Science, Kurume University, Japan
    Biochem Biophys Res Commun 239:439-46. 1997
  2. doi SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation
    Rai Hua Lai
    Institute of Pharmacology, National Yang Ming University, Taiwan, ROC
    Cancer Lett 288:75-85. 2010
  3. doi Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene
    Rai Hua Lai
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Gene 448:64-73. 2009
  4. pmc Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase
    Fahad Zadjali
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Biol Chem 286:480-90. 2011
  5. doi SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues
    Sungpil Yoon
    Research Institute, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang si, Gyeonggi do 411 764, South Korea
    Tumour Biol 33:215-21. 2012
  6. doi Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis
    Xinyu Qiu
    Department of Oral Medicine, Fourth Military Medical University, Xi an, China
    Mol Cell Biochem 378:99-106. 2013
  7. ncbi Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling
    Julie Bayle
    Institut National de la Santé et de la Recherche Médicale INSERM U119, Laboratoire d Hématopoïèse Moléculaire et Fonctionnelle, 27 Boulevard Lei Roure, 13009 Marseille, France
    J Biol Chem 279:12249-59. 2004
  8. pmc SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
    Danielle L Krebs
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria 3050, Australia
    Mol Cell Biol 22:4567-78. 2002
  9. doi miR-17-5p promotes proliferation by targeting SOCS6 in gastric cancer cells
    Qiong Wu
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    FEBS Lett 588:2055-62. 2014
  10. doi MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN
    Xinying Xue
    Department of Special Medical Treatment Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
    Oncotarget 7:84508-84519. 2016

Scientific Experts

Detail Information

Publications85

  1. ncbi Cloning and characterization of novel CIS family genes
    M Masuhara
    Institute of Life Science, Kurume University, Japan
    Biochem Biophys Res Commun 239:439-46. 1997
    ..Here we cloned three additional CIS family genes (CIS2, CIS3, and CIS4) on the basis of an expression sequence tag (EST) database search...
  2. doi SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation
    Rai Hua Lai
    Institute of Pharmacology, National Yang Ming University, Taiwan, ROC
    Cancer Lett 288:75-85. 2010
    ..By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC)...
  3. doi Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene
    Rai Hua Lai
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan, ROC
    Gene 448:64-73. 2009
    In this study, we report the expression and genomic structure of the gene encoding human suppressor of cytokine signaling 6 (SOCS6), and the characterization of the functional promoter region...
  4. pmc Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase
    Fahad Zadjali
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Biol Chem 286:480-90. 2011
    ..b>Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact with c-KIT and ..
  5. doi SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues
    Sungpil Yoon
    Research Institute, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang si, Gyeonggi do 411 764, South Korea
    Tumour Biol 33:215-21. 2012
    In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array...
  6. doi Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis
    Xinyu Qiu
    Department of Oral Medicine, Fourth Military Medical University, Xi an, China
    Mol Cell Biochem 378:99-106. 2013
    To investigate the clinical significance of suppressor of cytokine signaling (SOCS)-2 and SOCS6 in human hepatocellular carcinoma (HCC)...
  7. ncbi Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling
    Julie Bayle
    Institut National de la Santé et de la Recherche Médicale INSERM U119, Laboratoire d Hématopoïèse Moléculaire et Fonctionnelle, 27 Boulevard Lei Roure, 13009 Marseille, France
    J Biol Chem 279:12249-59. 2004
    ..The function of SOCS4, 5, 6, and 7 are not known...
  8. pmc SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
    Danielle L Krebs
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria 3050, Australia
    Mol Cell Biol 22:4567-78. 2002
    ..However, both male and female SOCS-6(-/-) mice weighed approximately 10% less than wild-type littermates...
  9. doi miR-17-5p promotes proliferation by targeting SOCS6 in gastric cancer cells
    Qiong Wu
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    FEBS Lett 588:2055-62. 2014
    ..Through reporter gene and western blot assays, SOCS6 was shown to be a direct target of miR-17-5p, and proliferative assays confirmed that SOCS6 exerted opposing ..
  10. doi MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN
    Xinying Xue
    Department of Special Medical Treatment Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
    Oncotarget 7:84508-84519. 2016
    ..In addition, miR-21 and miR-155 share nearly 30% of their predicted target genes, including SOCS1, SOCS6, and PTEN, three tumor suppressor genes often silenced in NSCLC...
  11. pmc The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
    Anjali Teckchandani
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States
    elife 5:. 2016
    ..Here we show that suppressor of cytokine signaling 6 (SOCS6) and Cullin 5, two components of the CRL5SOCS6 ubiquitin ligase, inhibit Cas-..
  12. doi Identification and expression analysis of suppressors of cytokine signaling (SOCS) of Japanese flounder Paralichthys olivaceus
    Kittipong Thanasaksiri
    Laboratory of Genome Science, Graduate School of Tokyo University of Marine Science and Technology, Konan 4 5 7, Minato, Tokyo 108 8477, Japan
    Fish Shellfish Immunol 58:145-152. 2016
    ..Here we identified eight SOCS proteins (CISH, SOCS1a, SOCS1b, SOCS3a, SOCS3b, SOCS5, SOCS6 and SOCS9) in the Japanese flounder and analyzed their mRNA expressions after injection of poly (I:C) and formalin-..
  13. pmc Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing
    Yi Feng
    Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Int J Mol Med 38:1349-1358. 2016
    ..Significantly higher levels of SOCS3 (P=0.0284) and SOCS4 (P=0...
  14. pmc MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages
    Afsar R Naqvi
    Department of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Currently at Department of Periodontics, University of Illinois at Chicago, Chicago, IL, USA
    Innate Immun 20:540-51. 2014
    ..of interleukin-6 receptorα (IL-6Rα) and IFN-γ inducible protein 30 and let-7f targeting of suppressor of cytokine signaling 4 and thrombospondin-1...
  15. pmc E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast
    Yue Fang
    Department of Biopharmaceutics, School of Pharmacy, China Medical University, Shenyang, China Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 9:e85238. 2014
    ..GPI)-anchored proteins including Ecm33, as multicopy suppressors of the phenotypes of a mutant allele of cis4(+) that encodes a zinc transporter in fission yeast...
  16. doi SOCS3 and SOCS6 are required for the risperidone-mediated inhibition of insulin and leptin signaling in neuroblastoma cells
    Longzhen Piao
    Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Int J Mol Med 33:1364-70. 2014
    ..and the mechanisms involved include the induction of suppressor of cytokine signaling 3 (SOCS3) and suppressor of cytokine signaling 6 (SOCS6) expression...
  17. doi New candidate loci identified by array-CGH in a cohort of 100 children presenting with syndromic obesity
    Marie Laure Vuillaume
    CHU Bordeaux, Service de Genetique Medicale, Bordeaux, France Univ Bordeaux, Maladies Rares Génétique et Métabolisme MRGM, EA 4576, Bordeaux, France
    Am J Med Genet A 164:1965-75. 2014
    ..in lipid metabolism (ACOXL, MSMO1, MVD, and PDZK1) linked with nervous system function (BDH1 and LINGO2), neutral lipid storage (PLIN2), energy homeostasis and metabolic processes (CDH13, CNTNAP2, CPPED1, NDUFA4, PTGS2, and SOCS6).
  18. pmc Characterization of microRNA transcriptome in lung cancer by next-generation deep sequencing
    Jie Ma
    Departments of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Mol Oncol 8:1208-19. 2014
    ..expression in NSCLC cells affected cell growth, proliferation, and invasion by targeting a tumor suppressor, SOCS4. Evaluating miR-944 in 52 formalin-fixed paraffin-embedded SCC tissues revealed that miR-944 expression was ..
  19. ncbi MiR-183 modulates multi-drug resistance in hepatocellular cancer (HCC) cells via miR-183-IDH2/SOCS6-HIF-1α feedback loop
    X J Wang
    Clinical Laboratory, the Central Hospital of Yishui, Linyi, Shandong, China
    Eur Rev Med Pharmacol Sci 20:2020-7. 2016
    ..This study aims to study the association between miR-183 dysregulation and multi-drug resistance (MDR). Also, how it is dysregulated in HCC cells was investigated...
  20. pmc Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection
    Lukasz Kedzierski
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria Australia Department of Medical Biology, The University of Melbourne, Parkville, Melbourne, Victoria, Australia
    PLoS Pathog 10:e1004134. 2014
    ..There is no described biological role for SOCS4, despite broad expression in the hematopoietic system...
  21. pmc The associations between immunity-related genes and breast cancer prognosis in Korean women
    Jaesung Choi
    Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea
    PLoS ONE 9:e103593. 2014
    ..05. The most significant SNPs were rs1952438 in SOCS4 gene (hazard ratio (HR) = 11.99, 95% CI = 3.62-39.72, P = 4...
  22. doi SOCS genes expression during physiological and perturbed implantation in bovine endometrium
    A Vitorino Carvalho
    INRAUMR1198 Biologie du Développement et Reproduction, F 78350 Jouy en Josas, FranceSchool of Agriculture and Food ScienceUniversity College Dublin, Dublin, IrelandCentre for Reproductive ImmunologyInstitute of Life Science, College of Medicine, Swansea University, Swansea SA28PP, UKDepartment of Pathology and ImmunologyBaylor College of Medicine, Houston, Texas, USASchool of Veterinary Medicine and ScienceUniversity of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, Leicestershire, UK
    Reproduction 148:545-57. 2014
    ..Altogether, our data showed that CISH, SOCS4, SOCS5 and SOCS7 mRNA levels were poorly affected during luteolysis and pregnancy...
  23. doi Maternal organism and embryo biosensoring: insights from ruminants
    Olivier Sandra
    INRA, UMR1198 Biologie du Développement et Reproduction, F 78352 Jouy en Josas, France ENVA, UMR1198 Biologie du Développement et Reproduction, F 94704 Maisons Alfort, France Electronic address
    J Reprod Immunol 108:105-13. 2015
    ..g. foxl2, socs6)...
  24. doi TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity
    Xiaolai Zhou
    Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Albert Ludwigs University Freiburg, Freiburg, Germany
    J Neurochem 134:125-34. 2015
    ..Interestingly, genes mediating negative regulation of IFNγ signaling, such as SOCS2 and SOCS6, were up-regulated after TGFβ1 treatment...
  25. doi Analysis of volatile compounds in powdered milk for infant nutrition by direct desorption (CIS4-TDU) and GC-MS
    Ieri Francesca
    PHYTOLAB laboratory, Scientific and Technological Pole, Via Ugo Schiff 6, Sesto Fiorentino, 50019 FIorence, Italy DiSIA Department of Statistics, Computer Sciences and Applications, University of Florence, Viale Morgagni 59, 50134 Florence, Italy Electronic address
    Talanta 141:195-9. 2015
    Direct thermal desorption coupled with the Gas Chromatography-Mass Spectrometry (TDU-CIS4-GC-MS) technique applied to powdered milk was used as a novel approach for the characterization and quantification, as relative abundance, of ..
  26. doi Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress
    Zefu Wang
    State Key Laboratory of Grassland Agro Ecosystem, College of Life Science, Lanzhou University, Lanzhou 730000, China Electronic address
    Gene 572:298-302. 2015
    ..We found that one gene, SOCS4, which is involved in the regulation of HIF-1α, showed a signature of convergent evolution...
  27. doi Feeding a high dosage of zinc oxide affects suppressor of cytokine gene expression in Salmonella Typhimurium infected piglets
    Jasper N Schulte
    Humboldt Universitat zu Berlin, Breeding Biology and Molecular Genetics, Invalidenstraße 42, D 10115 Berlin, Germany Electronic address
    Vet Immunol Immunopathol 178:10-3. 2016
    ..After 42days of infection, the expression of SOCS2, SOCS4, and SOCS7 was increased only in animals fed the highest concentrations of zinc oxide, while non-infected piglets ..
  28. doi Differential oncogene-related gene expressions in myeloma cells resistant to prednisone and vincristine
    Pelin Mutlu
    Middle East Technical University, Central Laboratory, Molecular Biology and Biotechnology R and D Center, Ankara, Turkey
    Biomed Pharmacother 66:506-11. 2012
    ..were seen to be altered in resistant MM sublines whereas suppressors of cytokine signalling genes such as SOCS2, SOCS4 and WSB2 were all downregulated...
  29. ncbi SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children
    Danuta Ostalska-Nowicka
    Department of Pediatric Cardiology and Nephrology, University of Medical Sciences, Poznan, Poland
    Folia Histochem Cytobiol 49:719-28. 2011
    ..children, the initial increased expression of JaK1, JaK2, JaK3, STAT1, STAT2, STAT6, TYK2, SOCS1, SOCS2, SOCS3, SOCS4 and SOCS5 was reduced back to the control limits...
  30. pmc Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation
    H Y Lin
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    Cell Death Differ 20:139-53. 2013
    ..We have previously shown that biallelic inactivation of the suppressor of cytokine signaling 6 (SOCS6) gene is a frequent event in human gastric cancer...
  31. doi Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation
    J M Sutherland
    Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    J Cell Physiol 227:1188-98. 2012
    ..Negative regulation of the JAK/STAT pathway is controlled by the suppressor of cytokine signaling 4 (SOCS4) protein, which target members of negative feedback loops, Cardiotrophin like Cytokine (CLC), ..
  32. doi Expression of SOCSs in human prostate cancer and their association in prognosis
    Jian Guo Zhu
    Department of Urology, Guizhou Provincial People s Hospital, Guizhou, China
    Mol Cell Biochem 381:51-9. 2013
    ..98, P = 0.031; at protein level: 5.12 ± 0.60 vs. 2.68 ± 0.37, P = 0.016) and SOCS6 expression was downregulated (at mRNA level: change ratio = -1.65, P = 0.008; at protein level: 3.03 ± 0.32 vs. 4...
  33. ncbi Functional cross-modulation between SOCS proteins can stimulate cytokine signaling
    Julie Piessevaux
    Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    J Biol Chem 281:32953-66. 2006
    ..We furthermore extended these observations to SOCS6 and SOCS7...
  34. doi MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer
    Kemin Wu
    Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, 410008, Changsha, Hunan Province, People s Republic of China
    Pathol Oncol Res 19:739-48. 2013
    ..of upregulated miR-424-5p in pancreatic cancer and show how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR-424-5p...
  35. ncbi Storage lipid accumulation and acyltransferase action in developing flaxseed
    Brent M Sørensen
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada
    Lipids 40:1043-9. 2005
    ..Acyl-CoA of EPA (20:5cisDelta5,8,11,14,17) or DHA (22:6 cis4,7,10,13,16,19) were included in the specificity studies...
  36. pmc Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
    Cornelia Johanna Franziska Scheitz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    EMBO J 31:4124-39. 2012
    ..Runx1 stimulates Stat3 signalling via direct transcriptional repression of SOCS3 and SOCS4 and this is essential for cancer cell growth...
  37. pmc Array-comparative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma
    Krishna B Sriram
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e30398. 2012
    ..Primary tumor recurrence commonly occurs after surgical resection of lung squamous cell carcinoma (SCC). Little is known about the genes driving SCC recurrence...
  38. ncbi High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression
    Fasong Zhou
    Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA
    Plant J 39:920-32. 2004
    The Arabidopsis ssi4 mutant, which exhibits spontaneous lesion formation, constitutive expression of pathogenesis-related (PR) genes and enhanced resistance to virulent bacterial and oomycete pathogens, contains a gain-of-function ..
  39. ncbi The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5
    Zhi Ping Feng
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Proteins 80:946-57. 2012
    ..and C-terminal SOCS box motifs of the SOCS proteins are well characterized, but the long N-terminal domains of SOCS4-7 remain poorly understood...
  40. pmc A gain-of-function mutation in an Arabidopsis Toll Interleukin1 receptor-nucleotide binding site-leucine-rich repeat type R gene triggers defense responses and results in enhanced disease resistance
    Yumiko Shirano
    Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA
    Plant Cell 14:3149-62. 2002
    ..of npr1-5-based salicylic acid (SA) insensitivity, we isolated a semidominant gain-of-function mutation, designated ssi4, that confers constitutive expression of several PR (pathogenesis-related) genes, induces SA accumulation, triggers ..
  41. pmc Studies on the roles of clathrin-mediated membrane trafficking and zinc transporter Cis4 in the transport of GPI-anchored proteins in fission yeast
    Wurentuya Jaiseng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e41946. 2012
    We previously identified Cis4, a zinc transporter belonging to the cation diffusion facilitator protein family, and we demonstrated that Cis4 is implicated in Golgi membrane trafficking in fission yeast...
  42. pmc Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3
    Julhash U Kazi
    Experimental Clinical Chemistry, Department of Laboratory Medicine, Lund University, Wallenberg Laboratory, Skane University Hospital, 20502 Malmo, Sweden
    J Biol Chem 287:36509-17. 2012
    ..SOCS6 (suppressor of cytokine signaling 6) is a member of the SOCS family of E3 ubiquitin ligases that can regulate receptor tyrosine kinase ..
  43. pmc Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
    Diego F Calvisi
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4262, USA
    J Clin Invest 117:2713-22. 2007
    ..Further, selective inactivation of SPRY1 and -2, DAB2, and SOCS4 and -5 genes and inhibitors of angiogenesis (BNIP3, BNIP3L, IGFBP3, and EGLN2) was associated with poor prognosis...
  44. ncbi Attenuation of leptin and insulin signaling by SOCS proteins
    Jane K Howard
    Endocrine Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Trends Endocrinol Metab 17:365-71. 2006
    ..evidence suggests that SOCS3 appears to be of particular importance in the development of leptin resistance, whereas the ability to diminish insulin action has been described for several SOCS proteins (SOCS1, SOCS3, SOCS6 and SOCS7).
  45. ncbi The relationship between chronic fatigue and somatization syndrome: a general population survey
    Alexandra Martin
    Section for Clinical Psychology and Psychotherapy, Philipps University, Marburg, Germany
    J Psychosom Res 63:147-56. 2007
    ....
  46. ncbi The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels
    Mi Na Hwang
    Research Institute, National Cancer Center, 809 Madu l dong, Ilsan gu, Goyang si Gyeonggi do 411 764, Republic of Korea
    Biochem Biophys Res Commun 360:333-8. 2007
    We determined that endogenous- and overexpressed- SOCS6 was localized in both the nucleus and cytoplasm...
  47. ncbi The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
    S Anastasi
    Department of Experimental Oncology, Laboratory of Immunology, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 26:7833-46. 2007
    ..attention is being drawn on transcriptionally controlled feedback inhibitors of EGFR, namely RALT/MIG6, LRIG1, SOCS4 and SOCS5...
  48. ncbi Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation
    Mi Na Hwang
    Research Institute, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang si Gyeonggi do 411 764, Republic of Korea
    Biochem Biophys Res Commun 354:184-9. 2007
    We investigated stability of the ectopically expressed the SOCS6 protein in HEK293T cells with PMA, which activates protein kinase C (PKC). The treatment of PMA could largely increase SOCS6 stability in HEK293T cells...
  49. ncbi Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation
    M A Cassatella
    Department of Pathology, University of Verona, Verona, Italy
    Blood 94:2880-9. 1999
    ..to the recently cloned cytokine-inducible SH2-containing protein (CIS) gene family (which also includes CIS1, CIS2, CIS4, CIS5, and JAB) that is believed to be, at least in part, under the control of STAT transcription factors and whose ..
  50. ncbi Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals
    M K Evans
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Oncogene 26:1941-8. 2007
    ..Compared to normal breast cells, we observe a high level constitutive expression of SOCS2, SOCS3, SOCS5, SOCS6, SOCS7, CIS and/or SOCS1 genes in the human cancer cells...
  51. pmc Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase
    Alex N Bullock
    Structural Genomics Consortium, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, United Kingdom
    Proc Natl Acad Sci U S A 103:7637-42. 2006
    ..is conserved in SOCS1-3 and CIS1, which share a strictly conserved length of their C termini, but not in SOCS4, 5, and 7, which have extended C termini defining two distinct classes of inter- and intramolecular SOCS box ..
  52. ncbi The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins
    Julie Bayle
    INSERM UMR599, Laboratoire d Hématopoïèse Moléculaire et Fonctionnelle, Marseille, France
    FEBS Lett 580:2609-14. 2006
    ..Here, we show that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), another E3 ubiquitin ligase, interacts with SOCS6. The Ubl domain of HOIL-1 and the SH2 and Socs-box domains of SOCS6 are required for the interaction...
  53. ncbi Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer
    Iana Storojeva
    Department of Research, University Hospital of Basel, Basel, Switzerland
    Oncology 68:246-55. 2005
    ..novel putative tumor suppressors, Cadh-7, DNAX accessory molecule-1 (Dnam-1) and suppressor of cytokine signaling (Socs6) on chromosome 18q and to correlate molecular results with patient survival and benefit from adjuvant chemotherapy.
  54. ncbi Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
    Edith Kario
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, 76100, Israel
    J Biol Chem 280:7038-48. 2005
    ..Here we show that the expression of SOCS5 and its closest homolog SOCS4 is elevated in cells following treatment with EGF, similar to several negative feedback regulators of EGFR whose ..
  55. pmc Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities
    Jason S Rawlings
    Dept of Biology, University of Kentucky, 101 Morgan Bldg Lexington, KY 40506, USA
    BMC Cell Biol 5:38. 2004
    ..Examination of one Drosophila SOCS homologue, Socs36E, demonstrated that its expression is responsive to JAK pathway activity and it is capable of downregulating JAK signaling, similar to the well characterized mammalian SOCS...
  56. pmc Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism
    Dagmar Nolte
    Institut fur Humangenetik, Justus Liebig Universitat, Schlangenzahl 14, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 100:10347-52. 2003
    ..Three exons overlap with ING2 (a putative tumor suppressor) and with a homologue of CIS4 (cytokine-inducible SH2 protein 4), both of which are encoded by the opposite strand...
  57. ncbi Differential roles of SOCS family members in EpoR signal transduction
    Armin G Jegalian
    Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095 1735, USA
    J Interferon Cytokine Res 22:853-60. 2002
    ..b>SOCS4 expression, in contrast, does not appear to be EPO inducible...
  58. ncbi Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins
    Liora Ben-Yair
    Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, The Hebrew University, Rehovot 76100, Israel
    Protein Expr Purif 25:456-64. 2002
    ..Constructs encoding DNA tagged with YFP or CFP upstream of SOCS1, SOCS2, SOCS3, and SOCS6 were prepared in pECFP-C1 and pEYFP-C1 plasmids...
  59. ncbi Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance
    R A Mooney
    Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 276:25889-93. 2001
    ..These results suggest that SOCS proteins may be inhibitors of IR signaling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes...
  60. doi CRT1, an Arabidopsis ATPase that interacts with diverse resistance proteins and modulates disease resistance to turnip crinkle virus
    Hong Gu Kang
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Cell Host Microbe 3:48-57. 2008
    ..crt1 also suppressed HR-like cell death induced by ssi4, a constitutively active R protein, and by Pseudomonas syringae carrying avrRpt2...
  61. doi Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS
    Tiehui Wang
    Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Fish Shellfish Immunol 29:656-67. 2010
    Four new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species...
  62. pmc Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast
    Yue Fang
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 19:1295-303. 2008
    ..confer sensitivities to the calcineurin inhibitor FK506 and to a high concentration of MgCl(2) and isolated the cis4-1 mutant, an allele of the gene encoding a cation diffusion facilitator (CDF) protein that is structurally related ..
  63. doi Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  64. pmc Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells
    Xuebin Liu
    Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Diabetes 57:1651-8. 2008
    ....
  65. doi Feedback inhibitors of the epidermal growth factor receptor signaling pathways
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Biochem Cell Biol 41:511-5. 2009
    ..FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1)...
  66. pmc Investigation of gene expression in C(2)C(12) myotubes following simvastatin application and mechanical strain
    Ji Guo Yu
    Department of Surgical and Perioperative Science, Sports Medicine Unite, Umea University, Umea, Sweden
    J Atheroscler Thromb 16:21-9. 2009
    ..The aim of the study was to investigate the molecular mechanisms that may mediate statin myopathy...
  67. doi Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways
    Joris Wauman
    Department of Medical Protein Research, University of Ghent, A Baertsoenkaai 3, 9000 Ghent, Belgium
    Mol Endocrinol 22:965-77. 2008
    ..IRS4 interacted with the regulatory p85 subunit of the phosphatidylinositol 3-kinase, phospholipase Cgamma, and the suppressor of cytokine signaling (SOCS) family members SOCS2, SOCS6, and SOCS7 and thus can modulate LR signaling.
  68. ncbi The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defense activation and morphological alterations
    Fasong Zhou
    Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA
    Mol Plant Microbe Interact 21:40-9. 2008
    A gain-of-function mutation in resistance (R) gene SSI4 causes constitutive activation of defense responses, spontaneous necrotic lesion formation, enhanced resistance against virulent pathogens, and a severe dwarf phenotype...
  69. pmc The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation
    Jin Liu
    Basic Science Program, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, Maryland, USA
    PLoS Comput Biol 5:e1000527. 2009
    ..Here, we simulated nine substrate binding proteins: Skp2, Fbw7, beta-TrCP1, Cdc4, Fbs1, TIR1, pVHL, SOCS2, and SOCS4, in the unbound form and bound to Skp1, ASK1 or Elongin C...
  70. pmc SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation
    Young Bong Choi
    Department of Life Science, Ewha Woman s University, 120 750 Seoul, Korea
    J Biol Chem 285:7271-80. 2010
    ..Moreover, SOCS-6 overexpression led to repression of TCR-dependent interleukin-2 promoter activity. These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis...
  71. doi Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica
    Timothée Bruel
    Institut National de la Recherche Agronomique, UR1282, Infectiologie Animale et Sante Publique, Nouzilly, Tours, France
    Dev Comp Immunol 34:562-71. 2010
    ..protozoan, Entamoeba histolytica, and we identified by rapid amplification of cDNA ends (RACE) PCR porcine SOCS1, SOCS4, SOCS5 and SOCS6 encoding sequences...
  72. pmc MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    J Infect Dis 202:125-35. 2010
    ..We report here that down-regulation of miR-98 and let-7 also coordinates epithelial expression of SOCS4 after C. parvum infection...
  73. doi Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis
    Daisuke Kobayashi
    Department of Surgery II, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    World J Surg 36:362-72. 2012
    ..Molecular mechanisms behind the oncogenesis of gastric cancer (GC) have yet to be identified...
  74. pmc SA-ABA antagonism in defense responses
    Wolfgang Moeder
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Plant Signal Behav 5:1231-3. 2010
    ..the antagonistic effects of salicylic acid (SA) and abscisic acid (ABA) in the lesion mimic mutants, cpr22 and ssi4. After shifting these mutants from high humidity, where the lesion mimic phenotype is suppressed to permissive low ..
  75. pmc Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation
    Alex N Bullock
    University of Oxford, Structural Genomics Consortium, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    Structure 15:1493-504. 2007
    ..SOCS assemble as SH2 domain substrate recognition modules in ElonginB/C-cullin ubiquitin ligases. In accordance, SOCS4 reduces STAT3 signaling from EGFR through increased receptor degradation...
  76. pmc Pim3 negatively regulates glucose-stimulated insulin secretion
    Gregory Vlacich
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 2:308-17. 2010
    ..Pim3 was also found to physically interact with SOCS6 and SOCS6 levels were strongly reduced in Pim3-/- islets...
  77. doi Investigating the inner speech of people who stutter: evidence for (and against) the covert repair hypothesis
    Paul H Brocklehurst
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    J Commun Disord 44:246-60. 2011
    ..However, the frequency of participants' inner-speech errors was not correlated to their SSI4 scores, nor to two other measures of stuttering severity...
  78. doi Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses
    Naohide Watanabe
    Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901 8550, USA
    Plant J 66:969-82. 2011
    ..proteins were found to correlate with conditional cell-death induction in two lesion-mimic mutants (cpr22 and ssi4) that exhibit spontaneous cell-death phenotypes...
  79. pmc Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells
    Catherine E Moffatt
    Center for Oral Health and Systemic Disease, School of Dentistry, University of Louisville, Louisville, Kentucky 40202, USA
    Infect Immun 79:2632-7. 2011
    ..Putative targets of miR-203, suppressor of cytokine signaling 3 (SOCS3) and SOCS6, were evaluated by qRT-PCR. SOCS3 and SOCS6 mRNA levels were reduced >5-fold and >2-fold, respectively, in P...
  80. doi [Examination of the stability of medically unexplained symptoms and somatoform disorders over time within the context of different diagnostic concepts]
    Natalie Steinbrecher
    Johannes Gutenberg Universitat, Klinische Psychologie, Mainz
    Psychother Psychosom Med Psychol 61:356-63. 2011
    The aim of this study was to determine and to compare the stability of medically unexplained symptoms and somatoform disorders within the context of different diagnostic concepts (SSI4/6, DSM-IV, DSM-V).
  81. doi Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
    Oreste Segatto
    Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy
    J Cell Sci 124:1785-93. 2011
    ..cells, four EGFR inducible feedback inhibitors (IFIs), namely LRIG1, RALT (also known as MIG6 and ERRFI1), SOCS4 and SOCS5, have been discovered recently...
  82. doi Expression of SOCS1-7 and CIS mRNA in porcine tissues
    Mario Delgado-Ortega
    Institut National de Recherche Agronomique, UR1282, Infectiologie Animale et Sante Publique, F 37380 Nouzilly, France
    Vet Immunol Immunopathol 144:493-8. 2011
    ..mRNA expression of SOCS1, SOCS3, SOCS7 and CIS was rather heterogeneous between tissues while for SOCS2, SOCS4, SOCS5 and SOCS6 differences of expression were less obvious...
  83. ncbi Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion
    Sheng Li Sun
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    Clin Exp Pharmacol Physiol 34:1097-101. 2007
    ..on global changes in STAT gene expression in the hippocampus of rats after focal cerebral ischaemia and reperfusion, in which STAT2, 5a, 5b, 6 and SOCS4 were confirmed to be significantly modulated during focal cerebral ischaemia.
  84. pmc Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition
    Sakshi Gupta
    Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India
    PLoS ONE 6:e26674. 2011
    ..The SOCS6 protein, a less extensively studied SOCS family member, has been shown to induce insulin resistance in the retina ..