SNAI1

Summary

Gene Symbol: SNAI1
Description: snail family transcriptional repressor 1
Alias: SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, zinc finger protein SNAI1, protein sna, protein snail homolog 1, snail 1 homolog, snail 1 zinc finger protein, snail family zinc finger 1, snail homolog 1
Species: human

Top Publications

  1. ncbi The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    E Batlle
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Nat Cell Biol 2:84-9. 2000
  2. doi Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    Muh Hwa Yang
    Institutes of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hepatology 50:1464-74. 2009
  3. pmc Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    T Lin
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Oncogene 29:4896-904. 2010
  4. pmc Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells
    Fan Fan
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center Houston, Texas, USA
    Cancer Med 1:5-16. 2012
  5. pmc Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma
    Lin Zhang
    Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    BMC Cancer 13:108. 2013
  6. doi Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients
    Susanne Hipp
    Institut fur Pathologie, Technische Universitat Munchen, Trogerstrasse 18, 81675, Munich, Germany
    Virchows Arch 457:705-13. 2010
  7. pmc Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Cell 15:416-28. 2009
  8. pmc The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    Yiwei Lin
    Departments of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
    EMBO J 29:1803-16. 2010
  9. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
  10. doi Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors
    José Manuel Mingot
    Instituto de Neurociencias, CSIC UMH, Avda Ramon y Cajal s n, San Juan de Alicante, Spain
    J Cell Sci 122:1452-60. 2009

Research Grants

  1. Withrow Gil Wier; Fiscal Year: 2015
  2. Mechanisms of Obesity-Induced Sympathetic Activation
    MARTIN SHAW MUNTZEL; Fiscal Year: 2011
  3. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
  4. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
  5. Blood pressure control by caudal ventrolateral medulla
    ANN SCHREIHOFER; Fiscal Year: 2009
  6. Mechanisms of Activity-Dependent Synaptic Plasticity
    AZEEZ AILERU; Fiscal Year: 2005
  7. Mechanisms underlying altered automic regulation of blood pressure in obesity
    Ann M Schreihofer; Fiscal Year: 2010
  8. Sympathetic Nerve Activity and Fine Motor Skills
    Minoru Shinohara; Fiscal Year: 2007
  9. Blood pressure control by caudal ventrolateral medulla
    Ann M Schreihofer; Fiscal Year: 2013
  10. COLIN NEAL YOUNG; Fiscal Year: 2014

Detail Information

Publications227 found, 100 shown here

  1. ncbi The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    E Batlle
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Nat Cell Biol 2:84-9. 2000
    ..Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-..
  2. doi Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    Muh Hwa Yang
    Institutes of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hepatology 50:1464-74. 2009
    ..2% and 51.5% of primary HCC samples, respectively. Overexpression of Snail, Twist, or Slug, the major regulators of EMT, was identified in 56.9%, 43.1%, and 51...
  3. pmc Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    T Lin
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Oncogene 29:4896-904. 2010
    ..Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce EMT in part by directly ..
  4. pmc Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells
    Fan Fan
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center Houston, Texas, USA
    Cancer Med 1:5-16. 2012
    ..Recently, EMT was shown to be associated with the cancer stem cell (CSC) phenotype in breast cancer. Snail is a transcription factor that mediates EMT in a number of tumor types, including colorectal cancer (CRC)...
  5. pmc Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma
    Lin Zhang
    Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    BMC Cancer 13:108. 2013
    ..In this study, we investigate the molecular mechanism by which hypoxia promotes HCC invasion and metastasis through inducing epithelial-mesenchymal transition (EMT)...
  6. doi Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients
    Susanne Hipp
    Institut fur Pathologie, Technische Universitat Munchen, Trogerstrasse 18, 81675, Munich, Germany
    Virchows Arch 457:705-13. 2010
    ..Additionally, over-expression of the E-cadherin repressor Snail, a key regulator of EMT, has previously been found to be associated with unfavourable prognostic features...
  7. pmc Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Cell 15:416-28. 2009
    ..In this study, we found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pathway...
  8. pmc The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    Yiwei Lin
    Departments of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA
    EMBO J 29:1803-16. 2010
    ..The mechanism underlying the epigenetic regulation of EMT remains unclear. In this study, we identified that Snail1 interacted with histone lysine-specific demethylase 1 (LSD1)...
  9. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
    ..Importantly, GSK-3 inhibition also stimulates the transcription of Snail, a repressor of E-cadherin and an inducer of the EMT...
  10. doi Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors
    José Manuel Mingot
    Instituto de Neurociencias, CSIC UMH, Avda Ramon y Cajal s n, San Juan de Alicante, Spain
    J Cell Sci 122:1452-60. 2009
    b>Snail proteins are C(2)H(2) class zinc finger transcription factors involved in different processes during embryonic development, as well as in several adult pathologies including cancer and organ fibrosis...
  11. pmc Activation of the ATM-Snail pathway promotes breast cancer metastasis
    Mianen Sun
    Department of Radiation Oncology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    J Mol Cell Biol 4:304-15. 2012
    ..and this hyperactivity correlates with elevated expression of the epithelial-mesenchymal transition marker, Snail. At the molecular level, we demonstrate that ATM regulates Snail stabilization by phosphorylation on Serine-100...
  12. pmc Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells
    Leah E Colvin Wanshura
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Cancer Res 71:5336-45. 2011
    ..We report that the transcription factor and oncogene Snail1 (Sna1) is directly induced by Shh pathway activity in GCPs, murine medulloblastomas, and human medulloblastoma ..
  13. pmc Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer
    Hao Wang
    Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e56664. 2013
    ..TNFα treatment also increased the expression of transcription factor Snail, but not Slug, ZEB1 and Twist...
  14. pmc Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor
    David Dominguez
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Mol Cell Biol 23:5078-89. 2003
    The Snail gene product is a transcriptional repressor of E-cadherin expression and an inducer of the epithelial-to-mesenchymal transition in several epithelial tumor cell lines...
  15. ncbi Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
    Sivan Elloul
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Cancer 103:1631-43. 2005
    It was demonstrated previously that the Snail family of transcription factors and Smad-interacting protein 1 (Sip1) regulate E-cadherin and matrix metalloproteinase 2 (MMP-2) expression, cellular morphology, and invasion in carcinoma...
  16. pmc Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma
    Yasunori Sato
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Am J Pathol 177:141-52. 2010
    ..TGF-beta1 also induced the nuclear expression of Snail, and the invasive activity was significantly increased in both cell lines...
  17. pmc Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
    Natàlia Dave
    Programa de Recerca en Càncer, IMIM Hospital del Mar, and Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Biol Chem 286:12024-32. 2011
    b>Snail1 and Zeb1 are E-cadherin-transcriptional repressors induced during epithelial mesenchymal transition (EMT). In this article we have analyzed the factors controlling Zeb1 expression during EMT...
  18. ncbi Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
    Maria José Barberà
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Oncogene 23:7345-54. 2004
    Expression of Snail transcriptional factor is a determinant in the acquisition of a mesenchymal phenotype by epithelial tumor cells. However, the regulation of the transcription of this gene is still unknown...
  19. ncbi Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH)
    T Okubo
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010 0269, USA
    Cancer Res 61:1338-46. 2001
    ..screen a human breast tissue hybrid cDNA expression library, we found that the zinc-finger transcriptional factor Snail (SnaH) interacted with a regulatory region near promoter I.3 of the human aromatase gene...
  20. ncbi A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    Jong In Yook
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, Seoul 120 752, Korea
    Nat Cell Biol 8:1398-406. 2006
    ..tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes...
  21. pmc Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression
    Luke S Wanami
    Duke University Medical Center, Department of Pathology, D U M C P O Box 3712, Durham, NC 27710, USA
    Exp Cell Res 314:2448-53. 2008
    The E-cadherin transcriptional repressor Snail is a prognostic marker for metastatic breast carcinoma, as well as a critical determinant of tumor growth and recurrence...
  22. doi p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
    Seung Oe Lim
    Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    FEBS Lett 584:2231-6. 2010
    The tumor suppressor protein p53 is a key regulator of cell cycle arrest and apoptosis. Snail protein regulates cancer-associated malignancies...
  23. ncbi E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations
    Cristina Peña
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Hum Mol Genet 14:3361-70. 2005
    E-cadherin (CDH1) gene expression is strictly regulated. The transcriptional factors SNAIL and ZEB1 are involved in its repression, whereas activation of vitamin D receptor (VDR) by vitamin D induces its transcription...
  24. ncbi Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract
    Erika Rosivatz
    Institut fur Pathologie, Technische Universitat Munchen, Trogerstrasse 18, Munchen, Germany
    Virchows Arch 448:277-87. 2006
    Transcriptional E-cadherin down-regulation can be mediated by Snail, a zinc finger transcription factor...
  25. ncbi Expression of Snail protein in tumor-stroma interface
    C Franci
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Oncogene 25:5134-44. 2006
    The product of Snail gene is a repressor of E-cadherin transcription and an inductor of the epithelial-to-mesenchymal transition in several epithelial tumor cell lines...
  26. ncbi Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer
    M H Yang
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Oncogene 26:1459-67. 2007
    ..NBS1 overexpression upregulated the expression of an EMT regulator Snail and its downstream target matrix metalloproteinase-2...
  27. ncbi The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas
    Kareen Blechschmidt
    Institute of Pathology, Technical University of Munich, Trogerstrasse, Germany
    Diagn Mol Pathol 16:222-8. 2007
    ..protein E-cadherin acts as a tumor-suppressor protein and is down-regulated by the transcription factor Snail, whose expression was shown to be associated with estrogen receptor signaling...
  28. doi Snail promotes Wnt target gene expression and interacts with beta-catenin
    V Stemmer
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Oncogene 27:5075-80. 2008
    The transcription factor snail represses epithelial gene expression and thereby promotes epithelial-mesenchymal transitions (EMT) and tumor invasion. The Wnt/beta-catenin pathway is also involved in EMT and was shown to activate snail...
  29. pmc Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer
    Michael G Backlund
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 68:9331-7. 2008
    ..we show that pretreatment of CRC cells with HDAC inhibitors can block epidermal growth factor-mediated or Snail-mediated transcriptional repression of 15-PGDH...
  30. ncbi The SLUG zinc-finger protein represses E-cadherin in breast cancer
    Karen M Hajra
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:1613-8. 2002
    ..Two zinc-finger transcription factors known to bind E-box elements, SLUG and SNAIL, repressed E-cadherin-driven reporter gene constructs containing wild-type promoter sequences but not those with ..
  31. ncbi Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Oncogene 21:3241-6. 2002
    b>Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression...
  32. ncbi Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
    Sandra Guaita
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, E 08003 Barcelona, Spain
    J Biol Chem 277:39209-16. 2002
    ..Recent evidence implicates the transcription factor Snail in the blockage of E-cadherin expression in fibroblasts and some epithelial tumor cells through direct binding to ..
  33. ncbi Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas
    Kazuhiro Yokoyama
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Tokushima, Tokushima, Japan
    Int J Oncol 22:891-8. 2003
    ..b>Snail is a zinc finger transcription factor that triggers the EMT and is one of the recently identified E-cadherin ..
  34. ncbi Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:1959-67. 2003
    b>Snail is a transcription repressor that plays a central role in the epithelium-mesenchyme transition (EMT), by which epithelial cells lose their polarity...
  35. pmc Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    Tsutomu Imai
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Pathol 163:1437-47. 2003
    ..In addition, hypoxia-induced change in the expression of SNAIL, a transcriptional factor repressing E-cadherin expression, was also analyzed...
  36. pmc Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
    Mol Cell Biol 24:306-19. 2004
    The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown...
  37. ncbi The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation
    Tadashi Ohkubo
    Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8544, Japan
    J Cell Sci 117:1675-85. 2004
    b>Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-mesenchymal transitions during development. We demonstrate that Snail activity is not restricted to E-cadherin downregulation...
  38. pmc Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
    Masahiro Kajita
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
    Mol Cell Biol 24:7559-66. 2004
    b>Snail and Slug are closely related transcriptional repressors involved in embryonic patterning during metazoan development...
  39. ncbi Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    Binhua P Zhou
    Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 6:931-40. 2004
    ..b>Snail, a zinc-finger transcription factor, triggers this process by repressing E-cadherin expression; however, the ..
  40. ncbi Wnt-dependent regulation of the E-cadherin repressor snail
    Jong In Yook
    Department of Oral Pathology, BK21 Project for Medical Science, College of Dentistry, Yonsei University, Seoul 120 742, Korea
    J Biol Chem 280:11740-8. 2005
    ..The zinc finger transcription factor, Snail, functions as a potent repressor of E-cadherin expression that can, acting alone or in concert with the Wnt/beta-..
  41. ncbi The transcriptional repressor SNAIL is overexpressed in human colon cancer
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Dig Dis Sci 50:42-6. 2005
    Overexpression of the transcriptional repressor, SNAIL, has been implicated in the pathogenesis of a number of malignancies; however, there are no previous reports on the role of SNAIL in colorectal cancers (CRCs)...
  42. pmc VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
    Andrew J Evans
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Cell Biol 27:157-69. 2007
    ..cells markedly reduced the expression of E2 box-dependent E-cadherin-specific transcriptional repressors Snail and SIP1 and concomitantly restored E-cadherin expression...
  43. pmc Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
    Hyun Jung Kim
    Baylor College of Medicine, Breast Center MS 600, One Baylor Plaza, Room N1110, Houston, TX 77030, USA
    Mol Cell Biol 27:3165-75. 2007
    ..The EMT was mediated by the induction of the transcriptional repressor Snail and downregulation of E-cadherin...
  44. ncbi Snail1 is involved in the renal epithelial-mesenchymal transition
    Jun Yoshino
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 362:63-8. 2007
    ..transition (EMT) in kidney diseases is becoming increasingly recognized, and the transcription factor Snail1 plays a critical role in EMT...
  45. pmc Snail is a repressor of RKIP transcription in metastatic prostate cancer cells
    S Beach
    Department of Biochemistry and Cancer Biology, College of Medicine, University of Toledo, Toledo, OH 43614 5804, USA
    Oncogene 27:2243-8. 2008
    ..Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelial-mesenchymal transition (EMT) ..
  46. pmc The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients
    K Blechschmidt
    Institute of Pathology, Technical University of Munich, Trogerstrasse 18, Munich D 81675, Germany
    Br J Cancer 98:489-95. 2008
    ..The role of the E-cadherin repressor Snail in ovarian cancer progression remains to be elucidated...
  47. ncbi SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells
    David Olmeda
    Departamento de Bioquimica, Facultad de Medicina, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 67:11721-31. 2007
    The transcription factor, SNAI1 (Snail), has recently been proposed as an important mediator of tumor invasion because of its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition...
  48. pmc Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1
    Wei Huang
    Department of Pathology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0605, USA
    Am J Pathol 172:893-904. 2008
    ..CCN6 knockdown in HME cells resulted in up-regulation of the E-cadherin transcriptional repressors Snail and ZEB1 and enhanced their recruitment and binding to the E-cadherin promoter as analyzed by chromatin ..
  49. pmc The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression
    Zhaoyuan Hou
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 28:3198-207. 2008
    The SNAIL transcription factor contains C-terminal tandem zinc finger motifs and an N-terminal SNAG repression domain...
  50. pmc HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 283:33437-46. 2008
    ..Among these, we analyzed in detail the zinc-finger transcription factor SNAIL1, which plays key roles in tumor progression and EMT...
  51. pmc Small C-terminal domain phosphatase enhances snail activity through dephosphorylation
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 284:640-8. 2009
    ..b>Snail, a key transcription repressor of E-cadherin, is a labile protein with a short half-life and is regulated through ..
  52. pmc Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function
    Sun Hye Lee
    Department of Molecular Biology, College of Natural Science, Pusan National University, Geumjeong Gu, Busan, South Korea
    Neoplasia 11:22-31, 6p following 31. 2009
    ..abrogates p53 function and expression through induction of Ataxia telangiectasia-mutated and Rad3-related mediated Snail stabilization...
  53. pmc Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Exp Med 206:221-32. 2009
    High malignancy and early metastasis are hallmarks of melanoma. Here, we report that the transcription factor Snail1 inhibits expression of the tumor suppressor CYLD in melanoma...
  54. doi Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma
    Marcus Franz
    Clinic of Internal Medicine I, University Hospital Jena, 07740, Jena, Germany
    Histochem Cell Biol 131:651-60. 2009
    b>Snail is a regulator of epithelial-mesenchymal transition (EMT) and considered crucial to carcinoma metastasis, myofibroblast transdifferentiation, and fibroblast activation...
  55. doi Snail1 is over-expressed in prostate cancer
    Sara Heebøll
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Brenstrupgaardsvej 100, Aarhus N, Denmark
    APMIS 117:196-204. 2009
    Transcription factor Snail1 is a mediator of cell migration and survival, and expression is elevated in several cancer types. The Snail1 gene is reportedly amplified in prostate cancer (PC), and we investigated Snail1 expression in PC...
  56. doi Transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma of the head and neck
    Nika Kojc
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia
    Virchows Arch 454:549-55. 2009
    ..Our aim is to analyze the expression of transcription repressors Snail, Slug, Twist, and SIP1 in SpCC of the head and neck in comparison to SCC, matched for location and stage...
  57. pmc Snail1 protein in the stroma as a new putative prognosis marker for colon tumours
    Clara Franci
    Programa de Recerca en Càncer, IMIM Hospital del Mar, Barcelona, Spain
    PLoS ONE 4:e5595. 2009
    Over-expression of Snail1 gene transcriptional repressor promotes an epithelial-to-mesenchymal transition in epithelial tumour cell lines...
  58. doi Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer
    Maria Jesus Larriba
    Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    Carcinogenesis 30:1459-68. 2009
    ..Previously, Snail1, an inducer of epithelial-to-mesenchymal transition (EMT), was reported to inhibit VDR expression...
  59. pmc Activation of epidermal growth factor receptor results in snail protein but not mRNA overexpression in endometrial cancer
    Susanne Hipp
    Technische Universitaet Muenchen, Institut fuer Pathologie, Muenchen, Germany
    J Cell Mol Med 13:3858-67. 2009
    ..The transcription factor Snail is known as one of the most prominent transcriptional E-cadherin repressors; its regulation in cancer tissues, ..
  60. pmc Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
    Hanna Tuhkanen
    Pathology and Forensic Medicine, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    BMC Cancer 9:289. 2009
    Transcription factor Snail1 has a central role in induction of epithelial-mesenchymal transition (EMT)...
  61. doi SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue
    C Pena
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
    Oncogene 28:4375-85. 2009
    b>SNAI1, ZEB1, E-cadherin (CDH1), and vitamin D receptor (VDR) genes regulate the epithelial-mesenchymal transition (EMT) that initiates the invasion process of many tumor cells...
  62. pmc Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1
    Ichiro Ota
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:20318-23. 2009
    ..the invasive phenotype has been linked to the aberrant expression of zinc-finger transcriptional repressors, like Snail1, which act by triggering an epithelial-mesenchymal cell-like transformation (EMT-like) via the regulation of ..
  63. pmc Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A
    Matthew Reid MacPherson
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, 28029 Madrid, Spain
    Mol Biol Cell 21:244-53. 2010
    b>Snail1 is a major factor for epithelial-mesenchymal transition (EMT), an important event in tumor metastasis and in other pathologies. Snail1 is tightly regulated at transcriptional and posttranscriptional levels...
  64. pmc The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation
    Rosa Viñas-Castells
    Programa de Recerca en Càncer, Institut Municipal d Investigacio Medica, Hospital del Mar, Parc de Recerca Biomedica de Barcelona, Doctor Aiguader 88, E 08003 Barcelona, Spain
    J Biol Chem 285:3794-805. 2010
    The transcription factor SNAIL1 is a master regulator of epithelial to mesenchymal transition...
  65. pmc Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells
    Danielle McKeithen
    Department of Biological Sciences, Clark Atlanta University, Atlanta, Georgia 30314, USA
    Prostate 70:982-92. 2010
    b>Snail transcription factor induces epithelial-mesenchymal transition (EMT) via decreased cell adhesion-associated molecules like E-cadherin, and increased mesenchymal markers like vimentin...
  66. doi Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines
    Modjtaba Emadi Baygi
    Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
    Cell Biol Toxicol 26:553-67. 2010
    ..We have investigated the function of Snail (SNAI1) in prostate cancer cells by downregulating its expression via short (21-mer) interfering RNA (siRNA) and ..
  67. pmc Novel snail1 target proteins in human colon cancer identified by proteomic analysis
    Maria Jesus Larriba
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 5:e10221. 2010
    The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT), a process responsible for the acquisition of invasiveness during tumorigenesis...
  68. doi Differential regulation of Snail by hypoxia and hyperglycemia in human proximal tubule cells
    Siska Sumual
    Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, New South Wales, Australia
    Int J Biochem Cell Biol 42:1689-97. 2010
    The centrality of the transcriptional regulator Snail in epithelial-to-mesenchymal transformation (EMT), known to occur in models of diabetic nephropathy, has not been established...
  69. doi Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer
    Dennis Shin Shian Hsu
    Institue of Biochemistry, National Chung Hsing University, Taichung, Taiwan
    Clin Cancer Res 16:4561-71. 2010
    ..We investigated the mechanism and clinical significance of the epithelial-mesenchymal transition (EMT)-induced chemoresistance in head and neck squamous cell carcinoma (HNSCC)...
  70. pmc Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
    Sang Yoon Park
    Department of Biology, Yonsei University, Seodaemun gu, Seoul, Korea
    EMBO J 29:3787-96. 2010
    ..O-phosphorylation of serine by glycogen synthase kinase-3β on Snail1, a transcriptional repressor of E-cadherin and a key regulator of the epithelial-mesenchymal transition (EMT) ..
  71. doi SNAI1 is involved in the proliferation and migration of glioblastoma cells
    Sung Pil Han
    Department of Anatomy, School of Medicine, Pusan National University, Beomeo Ri, Mulgeum Eup, Yangsan, South Korea
    Cell Mol Neurobiol 31:489-96. 2011
    ..b>SNAI1, an important regulator of epithelial-mesenchymal transition, has been associated with metastasis in various ..
  72. pmc Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas
    Joseph Geradts
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 42:1125-31. 2011
    b>Snail1 and ZEB1 are transcriptional repressors that drive tumor initiation and metastasis in animal models...
  73. ncbi Transcription factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma
    Anna Jouppila-Mättö
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
    Histol Histopathol 26:443-9. 2011
    b>Snail1, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in tumour progression. Previous studies of snail1 have mainly focused on the epithelial tumour cells...
  74. pmc Implication of snail in metabolic stress-induced necrosis
    Cho Hee Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan, Korea
    PLoS ONE 6:e18000. 2011
    ..Thus, metabolic stress-induced necrosis has important clinical implications for tumor development; however, its regulatory mechanisms have been poorly investigated...
  75. doi Poly(ADP-ribose)-dependent regulation of Snail1 protein stability
    M I Rodriguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Oncogene 30:4365-72. 2011
    b>Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis...
  76. doi Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients
    Johanna G H van Nes
    Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Breast Cancer Res Treat 133:49-59. 2012
    ..EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by transcription factors, such as SNAIL, SLUG, and TWIST...
  77. doi Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis
    Shuji Mikami
    Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan
    Lab Invest 91:1443-58. 2011
    The Snail family transcription factors have been proposed as important mediators of epithelial-mesenchymal transition because of their role in down-regulation of E-cadherin and up-regulation of matrix metalloproteinases (MMPs)...
  78. pmc Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
    Kun Zhang
    Department of Medicine, The BRIGHT Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 31:29-43. 2012
    b>Snail1 is a central regulator of epithelial cell adhesion and movement in epithelial-to-mesenchymal transitions (EMTs) during embryo development; a process reactivated during cancer metastasis...
  79. pmc Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence
    David D Tran
    Department of Medicine, Washington University Schoolof Medicine, Saint Louis, MO 63088, USA
    Mol Cancer Res 9:1644-57. 2011
    ..to better mimic in vivo conditions we show, in both nontumorigenic and tumorigenic epithelial cancer cells, that Snail1 is uniquely required for EMT initiation, whereas Twist1 is required to maintain late EMT...
  80. pmc A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 752, South Korea
    J Cell Biol 195:417-33. 2011
    b>Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition (EMT) programs and the induction of tissue-invasive activity, but pro-oncogenic events ..
  81. pmc The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    Archana Dhasarathy
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e26514. 2011
    The transcriptional repressors Snail and Slug are situated at the core of several signaling pathways proposed to mediate epithelial to mesenchymal transition or EMT, which has been implicated in tumor metastasis...
  82. doi miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilians University Munich, Munich, Germany
    Cell Cycle 10:4256-71. 2011
    ..Here we report that activation of p53 down-regulates the EMT-inducing transcription factor SNAIL via induction of the miR-34a/b/c genes...
  83. doi Snail overexpression induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells
    Li Fang Zhu
    Department of Basic Science of Stomatology, Institute of Stomatology, Nanjing Medical University, Nanjing, People s Republic of China
    Lab Invest 92:744-52. 2012
    ..b>Snail is a transcriptional factor that can induce EMT and preserve stem-cell function, which may induce resistance to ..
  84. pmc G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
    Chenfang Dong
    Department of Molecular and Cellular Biochemistry, The University of Kentucky, College of Medicine, Lexington, Kentucky 40506 0509, USA
    J Clin Invest 122:1469-86. 2012
    ..Further, Snail interacted with G9a, a major euchromatin methyltransferase responsible for H3K9me2, and recruited G9a and DNA ..
  85. pmc Analysis of Snail-1, E-cadherin and claudin-1 expression in colorectal adenomas and carcinomas
    Michala Bezdekova
    Laboratory of Molecular Pathology, Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic E Mails M B E S
    Int J Mol Sci 13:1632-43. 2012
    We report the expression of Snail-1, E-cadherin and claudin-1 by indirect immunohistochemistry in colonic neoplasia...
  86. doi Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction
    A Deshiere
    INSERM, U1036, Grenoble, France
    Oncogene 32:1373-83. 2013
    ..EMT-like morphological changes, enhanced migration, and anchorage-independent growth, all of which require Snail1 induction...
  87. doi Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer
    Xin Juan Fan
    Department of Pathology, Sixth Affiliated Hospital, Sun Yat Sen University, Guangzhou 510655, China
    Hum Pathol 44:173-80. 2013
    b>Snail and Twist, transcriptional repressors of E-cadherin as well as inducers of epithelial-mesenchymal transition, play pivotal roles in tumor invasion and metastasis...
  88. pmc Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas
    Feride Kroepil
    Department of General, Visceral and Pediatric Surgery, University Hospital Dusseldorf, Dusseldorf, Germany
    PLoS ONE 7:e46665. 2012
    ..Here we tested whether the important regulators of E-cadherin expression SNAI1 and TWIST1 are already detectable in human colorectal adenomas.
  89. doi Possible regulatory role of Snail in NF-κB-mediated changes in E-cadherin in gastric cancer
    Zenan Hu
    First Clinical Medical School of Lanzhou University, Lanzhou 730000, PR China
    Oncol Rep 29:993-1000. 2013
    In the present study, we aimed to investigate the involvement of Snail in NF-κB-mediated changes of E-cadherin in gastric cancer...
  90. doi MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells
    Udainiya Savita
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India
    Biochem Biophys Res Commun 434:841-7. 2013
    ..TRCP2-3'UTR reporter assay revealed that its activity in CL cells was only 60% of that in EV cells. Snail protein expression was higher in CL than that in EV cells and H1299 cells exhibited an increase in the expression ..
  91. pmc A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier, Madrid, Spain
    EMBO J 24:3446-58. 2005
    The transcription factor Snail controls epithelial-mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes...
  92. ncbi Cancer development induced by graded expression of Snail in mice
    Pedro Antonio Pérez-Mancera
    Laboratorio 13, Instituto de Biología Molecular y Celular del Cáncer IBMCC, CSIC Universidad de Salamanca, Campus Unamuno, Spain
    Hum Mol Genet 14:3449-61. 2005
    The zinc-finger transcription factor Snail is believed to trigger epithelial-mesenchymal transitions (EMTs) during cancer progression...
  93. ncbi [Comparative computerized tomography cephalometric and pharyngometric studies of patients with severe and mild sleep apnea, and in a control group]
    J Bolitschek
    Pneumologische Abteilung, K.H. Elisabethinen, Linz
    Pneumologie 47:757-60. 1993
    ..pharyngeal wall at the level of the second cervical vertebra, or axis, and the angles between the sella, nasion and superior maxilla and between the sella, nasion and mandible (SNA and SNB, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
  94. ncbi Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents
    M Hausberg
    Department of Internal Medicine, Cardiovascular, Research Center, University of Iowa College of Medicine, Veterans Affairs Medical Center, Iowa City, USA
    Am J Hypertens 11:1312-20. 1998
    Insulin resistance and elevated sympathetic nerve activity (SNA) are observed in young borderline hypertensive humans. A positive family history of hypertension (FH) is a strong risk factor for developing hypertension...
  95. ncbi Comparison of cephalometric analysis with ethnicity in obstructive sleep apnea syndrome
    M J Will
    Department of Oral and Maxillofacial Surgery, Brooke Army Medical Center, Fort San Houston, Texas 78234, USA
    Sleep 18:873-5. 1995
    ..Cephalometric landmarks, angles and measurements [angle measured from sella to nasion to subspinale point (SNA), angle measured from sella to nasion to supramentale point (SNB), difference between SNA and SNB (ANB), ..
  96. ncbi Reaction of various lectins to mucin derived from the different layers of rat gastric mucosa: comparison of enzyme-linked lectin binding assay with lectin histochemistry
    H Kodaira
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Pharm Bull 23:1173-9. 2000
    ..Arachis hypogaea (PNA), Glycine max (SBA), Dolichos biflorus (DBA), Ulex europaeus I (UEA-I), Sambucus nigra (SNA) and Maackia amurensis II (MAL-II), examined in this study, GS-II, SBA, DBA, UEA-I, SNA and MAL-II bound clearly to ..
  97. doi Lectin-binding sites on ejaculated stallion sperm during breeding and non-breeding periods
    S Desantis
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine, University of Bari, Italy
    Theriogenology 73:1146-53. 2010
    ..The acrosomal cap showed reactivity for Maackia amurensis (MAL II), Sambucus nigra (SNA), Arachis hypogaea (PNA), Glycine max (SBA), Helix pomatia (HPA), Canavalia ensiformis (Con A) Triticum vulgaris (..
  98. ncbi Immunohistochemical detection of sepsis-induced lung injury in human autopsy material
    Michael Tsokos
    Institute of Legal Medicine, University of Hamburg, Butenfeld 34, D 22529, Hamburg, Germany
    Leg Med (Tokyo) 5:73-86. 2003
    ..Application of carbohydrate-specific lectins (ConA, UEA, GSA I, GSA II, MPA, PNA, Jac, WGA, MAA, LPA, SNA) on deparaffinated lung tissue sections from sepsis-associated fatalities and control cases results to some extent ..
  99. ncbi Hemodynamic and sympathoinhibitory effects of nasal CPAP in congestive heart failure
    T D Bradley
    Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada
    Sleep 19:S232-5. 1996
    ..may be that apnea-related hypoxia and arousals from sleep can increase sympathetic nervous system activity (SNA), as manifested by increases in overnight urinary and daytime plasma norepinephrine concentrations ([UNE] and [PNE],..
  100. doi Lectin mapping reveals stage-specific display of surface carbohydrates in in vitro and haemolymph-derived cells of the entomopathogenic fungus Beauveria bassiana
    Arun Wanchoo
    Department of Microbiology, University of Florida, Gainesville, FL 32611, USA
    Microbiology 155:3121-33. 2009
    ..I (UEAI) and wheatgerm agglutinin (WGA), and weak reactivity against Ricinus communis I (RCA), Sambucus nigra (SNA), Limax flavus (LFA) and Sophora japonica (SJA) lectins...
  101. ncbi Vasopressor responses and hyperthermia by intracerebroventricular injections of penicillin, a pyrogen, in rats: involvement of brain angiotensin II
    H Takahashi
    Second Department of Medicine Kyoto Prefectural University of Medicine, Japan
    Am J Hypertens 1:26S-33S. 1988
    ..ICV injections increased the mean arterial pressure (MAP), heart rate (HR) and the abdominal sympathetic activity (SNA) dose-dependently in urethane-anesthetized rats...

Research Grants69

  1. Withrow Gil Wier; Fiscal Year: 2015
    ..Two key determinants of arterial diameter, and hence of arterial BP in vivo, are sympathetic nerve activity (SNA) and myogenic tone (MT)...
  2. Mechanisms of Obesity-Induced Sympathetic Activation
    MARTIN SHAW MUNTZEL; Fiscal Year: 2011
    ..The hypothesis that obesity increases sympathetic nerve activity (SNA) is based on the following evidence: (1) overweight results in chronic elevations in leptin and insulin;(2) leptin ..
  3. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
    ..novel experimental and mathematical techniques for quantifying the relationship between sympathetic nerve activity (SNA) and blood pressure in the conscious rat at rest, and in response to an acute behavioral challenge...
  4. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..It is known that sympathoexcitation is inversely related to disease prognosis. Sympathetic nervous activity (SNA) is increased with exercise in normal subjects and is increased in HF patients at rest and in response to exercise...
  5. Blood pressure control by caudal ventrolateral medulla
    ANN SCHREIHOFER; Fiscal Year: 2009
    ..Many forms of essential hypertension are associated with augmented sympathetic nerve activity (SNA), although the basis of the sympatho-activation is not well understood...
  6. Mechanisms of Activity-Dependent Synaptic Plasticity
    AZEEZ AILERU; Fiscal Year: 2005
    ..humans and animal models of hypertension exhibit increased peripheral sympathetic nervous system activity (SNA)...
  7. Mechanisms underlying altered automic regulation of blood pressure in obesity
    Ann M Schreihofer; Fiscal Year: 2010
    ..OZR) have autonomic deficits analogous to those observed in obese people: increased sympathetic nerve activity (SNA) with hypertension, blunted baroreflex-mediated changes in SNA, and exaggerated increases in SNA and AP with other ..
  8. Sympathetic Nerve Activity and Fine Motor Skills
    Minoru Shinohara; Fiscal Year: 2007
    ..there is evidence that suggests an increase in sensitivity of the la afferent circuit due to heightened SNA, and associations between the sensitivity of the la afferent circuit and force fluctuations in humans...
  9. Blood pressure control by caudal ventrolateral medulla
    Ann M Schreihofer; Fiscal Year: 2013
    ..Many forms of essential hypertension are associated with augmented sympathetic nerve activity (SNA), although the basis of the sympatho-activation is not well understood...
  10. COLIN NEAL YOUNG; Fiscal Year: 2014
    ..accumulating evidence from humans and animal models indicate that excessive central sympathetic nerve activity (SNA) plays a pathogenic role in obesity-associated hypertension...
  11. CURT DANIEL SIGMUND; Fiscal Year: 2016
    ..role of brain endoplasmic reticulum (ER) and oxidant stress as mechanisms regulating sympathetic nerve activity (SNA), blood pressure and energy homeostasis. The projects will test several novel hypothesis...
  12. JODY GREANEY; Fiscal Year: 2015
    ..cold exposure, a physiologic stress that causes increases in blood pressure (BP) and sympathetic nerve activity (SNA) and reductions in skin blood flow...
  13. Colin Sumners; Fiscal Year: 2016
    ..in microglial activation in the PVN, mediated by the CCL2/CCR2 chemokine system, are key early events in enhancing SNA in HTN...
  14. Wanpen Vongpatanasin; Fiscal Year: 2016
    ..The increase in SNA and BP caused by activation of these receptors, known as exercise pressor reflex, is normally buffered by ..
  15. Michael S Levine; Fiscal Year: 2016
    ..Most of our proposed studies focus on mechanisms of transcriptional precision. For example, Snail, a key regulator of epithelial-mesenchyme transitions, is expressed in 800 mesoderm progenitor cells slated for ..
  16. Shilpa Vyas-Read; Fiscal Year: 2014
    ..Vyas- Read will investigate if 1) NADPH oxidase-derived ROS promote EMT, 2) if ROS induce alveolar EMT through SNAI1 transcription factors and 3) how glutathione and its regulator, Nrf-2, attenuate alveolar EMT...
  17. Qihong Huang; Fiscal Year: 2014
    ..We will also investigate the molecular mechanisms of KLF17 regulation by SNAI1 (Snail), a known EMT regulator, transcriptionally and by microRNA miR-129 post-transcriptionally...
  18. Time Domains of Sympathetic Activity following Hypoxia
    James Weiss; Fiscal Year: 2006
    ..Although some evidence also exists that changes in sympathetic nervous system activity (SNA) persist after hypoxic exposure, the time domains of these changes and the mechanisms that underlie these ..
  19. MECHANISMS MEDIATING CARDIOVASCULAR RESPONSES TO SMOKING
    Virend Somers; Fiscal Year: 2003
    ..demonstrated that smoking increases heart rate and blood pressure and decreases muscle sympathetic nerve activity (SNA) in healthy subjects...
  20. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..It is known that sympathoexcitation is inversely related to disease prognosis. Sympathetic nervous activity (SNA) is increased with exercise in normal subjects and is increased in HF patients at rest and in response to exercise...
  21. Genetic Analysis of Snail Superfamily Genes in Mice
    THOMAS HOOKER GRIDLEY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Snail superfamily genes encode zinc finger-containing DNA binding proteins that act as transcriptional repressors...
  22. Cynthia Chappell; Fiscal Year: 2014
    ..standard and currently the only specific method for detecting AdV36 antibodies is the serum neutralization assay (SNA)-a complicated and time-consuming method that has produced inconsistent results among laboratories...
  23. Force spectroscopy platform for label free genome sequencing
    DMITRI VEZENOV; Fiscal Year: 2010
    ..genome sequencing, a new basic concept for DNA sequencing is proposed: detection of a single nucleotide addition (SNA) can be based on changes in mechanical properties and molecular structure of single DNA fragments...
  24. Men?s Assessment of Social Support and Risk Networks
    David G Ostrow; Fiscal Year: 2010
    ..available to a large number of researchers who use the MACS, thus facilitating the use of social network analysis (SNA) in large, prospective study of MSM...
  25. Using SNA to Examine the Long-Term Outcomes of Socially Excluded Adolescents
    RICHARD CARL GILMAN; Fiscal Year: 2013
    ....
  26. Karla D Wagner; Fiscal Year: 2014
    ..This award will allow me to: 1) learn a new skill set (social network analysis;SNA), 2) broaden my understanding of the social epidemiology of HIV among drug users in a new cultural and ..
  27. Molecular actions of tumor-derived endothelin-1 in the bone microenvironment
    Gregory A Clines; Fiscal Year: 2010
    ..Dr. Clines has identified major factors regulated by ET-1 in osteoblasts: dickkopf homolog 1 (Dkk1) and snail homolog 1 (Snai1)...
  28. MARK STEPHEN HANDCOCK; Fiscal Year: 2014
    ..models are capable of representing the complex dependencies in social phenomena, and have been well studied in SNA. However, they do not represent the social endogeneity of nodal characteristics but only that of the relations...
  29. AngII-Salt Hypertension Increases Respiratory-Vasomotor Neuron Coupling in RVLM
    Glenn M Toney; Fiscal Year: 2013
    ..provided by applicant): This project will investigate neural mechanisms of elevated sympathetic nerve activity (SNA), which is now widely recognized to play a key role in many forms of human hypertension (HTN)...
  30. Harold D Green; Fiscal Year: 2015
    ..2) "develop innovative methodologies and technologies to facilitate, improve, and expand the capabilities of SNA" by employing innovative network analytic methods and state-of-the-art modeling approaches to better understand ..
  31. Ann Marie White; Fiscal Year: 2015
    ..For example, social network analysis (SNA), a strand of systems science, offers a unique lens to understand how human interactions through social network may ..
  32. ACUPUNTURE AND HYPERTENSION: EFFICACY AND MECHANISMS
    Norman Kaplan; Fiscal Year: 2000
    ..central endorphin (naloxone-sensitive) pathways that elicit long-lasting decreases in sympathetic nerve activity (SNA) and blood pressure...
  33. SocioWorks: Integrated Web Platform for Applications of Social Network Analysis
    Allen Y Tien; Fiscal Year: 2012
    ..product, named "SocioWorks"", is intended to meet emerging needs in markets for applying Social Network Analysis (SNA) to solve problems and generate new knowledge in the health domain...
  34. Central Sympatholysis for Cocaine-Induced Coronary Vasoconstriction in Humans.
    Andrew Kontak; Fiscal Year: 2009
    ..stimulates the human cardiovascular system primarily by acting in the brain to increase sympathetic nerve activity (SNA), the neural stimulus to NE release...
  35. ESTROGEN/SYMPATHETIC VASOCONSTRICTION IN SKELETAL MUSCLE
    Gail Thomas; Fiscal Year: 2003
    ..Thomas will measure forearm muscle oxygenation with NIR spectroscopy while recording muscle SNA with microelectrodes...
  36. UNIT CONTROL OF MUSCLE BLOOD FLOW
    STEVEN SEGAL; Fiscal Year: 2007
    ..The interaction between skeletal muscle contractions and sympathetic nerve activity (SNA) determines muscle blood flow and arterial pressure during exercise through governing the diameter of resistance ..
  37. COMPARING MEMBRANE-BOUND & SOLUBLE GLYCOSYLTRANSFERASES
    William Young; Fiscal Year: 2002
    ..immunoprecipitated with antibodies specific for H-2Kb and then lectin blotted with the Sambucus nigra agglutinin (SNA), a lectin specific for a2, 6-linked sialic acid...
  38. CONTROL-RESPIRATORY MODULATION OF SYMPATHETIC ACTIVITY
    Thomas Dick; Fiscal Year: 2003
    ..The increased blood pressure appears to result from an up-regulation of basal sympathetic nerve activity (SNA). Treatment reverses this up-regulation...
  39. Forebrain Neurohumoral Integration in Heart Failure
    SEAN STOCKER; Fiscal Year: 2005
    ..terminalis including the nucleus medianus (NM or median preoptic nucleus) and increase sympathetic nerve activity (SNA)...
  40. ESTROGEN AND BLOOD PRESSURE DYNAMICS IN AGING WOMEN
    Lewis Lipsitz; Fiscal Year: 1999
    ..This hypothesis will be tested by measuring beat-to-beat BP, sympathetic nerve activity to the leg vasculature (SNA), and calf blood flow (CBF) in response to nitroprusside infusion, in 24 healthy post-menopausal women before and ..
  41. Kathleen M Carley; Fiscal Year: 2016
    ..applicant): Our proposed basic research program will enhance the scientific application of social network analysis (SNA) to health care in several ways: First, we will compare information sharing and decision-making networks in ..
  42. HYPERTENSION IN THE ELDERLY--EFFECTS OF EXERCISE
    DOUGLAS SEALS; Fiscal Year: 1992
    ..cardiac autonomic efferent activity, cardiac dimensions and contractility, efferent sympathetic nerve activity (SNA), and carotid and cardiopulmonary baroreceptor regulation of heart rate and efferent SNA will be either measured or ..
  43. CD36 AND LIPOPROTEINS AND HYPERTENSION
    Eric Smart; Fiscal Year: 2002
    ..This will be accomplished by measuring SNA and blood pressure in C57BL/6, CD36 null, apoE null and CD36 x apoE null mice as a function of the degree of ..
  44. Sympathetic Axonal Activity in Conscious Rats During Development of Hypertension
    MARK KNUEPFER; Fiscal Year: 2009
    Sympathetic nerve activity (SNA) has been recorded in conscious humans and animals for more than 3 decades with the intent of determining whether elevated SNA contributes to the development of heart disease and hypertension...
  45. Long-Term Neural Determinants of Cardiovascular Diseases
    John Osborn; Fiscal Year: 2009
    ..disease (CVD) requires a detailed understanding of the long-term controllers of sympathetic nerve activity (SNA). Advances in this field require research at the genomic, cellular, neural network and whole animal levels...
  46. Skin Blood Flow in Diabetes: Local and Reflex Control
    Nisha Charkoudian; Fiscal Year: 2007
    ....
  47. NEURAL MECHANISMS OF LONG-TERM CARDIOVASCULAR CONTROL
    John Osborn; Fiscal Year: 2007
    ..Taken together, this integrative physiological approach will advance our understanding of the neural mechanisms for long-term control of arterial pressure and pathogenesis of neurogenic hypertension. [unreadable] [unreadable]..
  48. Cardiac sympathetic drive mechanism in heart failure
    Clive May; Fiscal Year: 2007
    ..The results will increase understanding of a deadly disease and help guide future approaches to therapy and prevention. [unreadable] [unreadable]..
  49. Neural Mechanism of Thiazide-Induced Insulin Resistance
    Wanpen Vongpatanasin; Fiscal Year: 2008
    ..of hypertensive subjects, whether chlorthalidone causes a sustained increase in muscle sympathetic nerve activity (SNA), promoting neurogenic vasoconstriction and reducing glucose extraction by skeletal muscle and if spironolactone ..
  50. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ....
  51. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  52. Mitochondrial respiratory uncoupling and the pathogenes*
    William Sivitz; Fiscal Year: 2006
    ..This is mediated by one or more UCP subtype. 4. Altered mitochondrial coupling and consequent changes in mitochondrial ROS formation alter endothelial cell generation of nitric oxide. ..
  53. POSTMENOPAUSAL HORMONAL REPLACEMENT THERAPY
    Wanpen Vongpatanasin; Fiscal Year: 2006
    ..Using intraneural microelectrodes to record postganglionic SNA in normotensive postmenopausal women, the applicant recently provided direct evidence for a major ..
  54. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  55. Humoral Interactions in long-term blood pressure control
    VIRGINIA BROOKS; Fiscal Year: 2005
    ..abstract_text> ..
  56. Effects of Hospitalists in Medicare Data
    David Meltzer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. 19th Annual Health Economics Conference
    David Meltzer; Fiscal Year: 2008
    ..The 19th annual Health Economics conference hopes to build upon the rich tradition established by the preceding Annual Health Economics Conferences. [unreadable] [unreadable] [unreadable]..
  58. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  59. VASCULAR EFFECTS OF HOMOCYSTEINE IN HUMANS
    WILLIAM HAYNES; Fiscal Year: 2005
    ..The results may also suggest novel potential therapeutic approaches to be tested in future outcome trials. ..
  60. Biomechanical Mechanisms and Venous Intimal Hyperplasia
    Hisham Bassiouny; Fiscal Year: 2005
    ..abstract_text> ..
  61. Metalloproteinase regulation of ErbB signaling in skin
    Stefan Stoll; Fiscal Year: 2006
    ..Specific Aim 2 determines whether and in which contexts ADAM10 is involved in the shedding of ErbB ligands in human KCs. ..
  62. CARDIAC GLYCOSIDES FROM THE ADRENAL GLAND
    John Hamlyn; Fiscal Year: 2007
    ..The implications for the life sciences and medicine are both broad and profound and will form the basis for fundamentally new therapeutic modalities for hypertension and heart failure. [unreadable] [unreadable]..
  63. Arterial baroreceptor unloading causes hypertension
    TERRY THRASHER; Fiscal Year: 2005
    ..These studies will provide a new framework for understanding the development and maintenance of hypertension. ..
  64. Uterine circulatory response to exercise in pregnancy
    KATHLEEN O HAGAN; Fiscal Year: 2004
    ..abstract_text> ..
  65. Cost-Effectiveness of Prostate Cancer Screen/Treatment
    David Meltzer; Fiscal Year: 2003
    ..3. To assess how the cost-effectiveness of prostate cancer screening and treatment will be affected by the appropriate inclusion of future medical and non-medical costs in cost- effectiveness analysis. ..
  66. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  67. Exercise and Vascular Function in Paraplegic
    STEPHEN DICARLO; Fiscal Year: 2006
    ..The clinical significance of the post-exercise modulation of vascular function will be determined by the evaluating the cardiovascular and sympathetic nerve responses to colon distension. ..
  68. HYPOTHALAMIC CARDIOVASCULAR AFFERENT INTEGRATION
    GLENN TONEY; Fiscal Year: 2002
    ..The results will provide new insight into the role of diverse autonomic pathways arising from the PVN in maintaining volume and osmotic homeostasis. ..
  69. Neural Mechanisms in Congestive Heart Failure
    GLENN TONEY; Fiscal Year: 2007
    ..level of plasma angiotensin II (ANG II) in CHF acts within the brain to increase sympathetic nerve activity (SNA)...