SLPI

Summary

Gene Symbol: SLPI
Description: secretory leukocyte peptidase inhibitor
Alias: ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, antileukoproteinase, HUSI-1, WAP four-disulfide core domain protein 4, mucus proteinase inhibitor, protease inhibitor WAP4, secretory leukocyte protease inhibitor (antileukoproteinase), seminal proteinase inhibitor
Species: human

Top Publications

  1. pmc Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease
    Emer P Reeves
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Biomed Res Int 2013:560141. 2013
  2. pmc Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons
    Amit Chattopadhyay
    School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Infect Immun 72:1956-63. 2004
  3. pmc The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
    Bénédicte Py
    Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    PLoS ONE 4:e5006. 2009
  4. ncbi Location of the protease-inhibitory region of secretory leukocyte protease inhibitor
    S P Eisenberg
    Synergen Inc, Boulder, Colorado 80301
    J Biol Chem 265:7976-81. 1990
  5. pmc Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase
    R C Thompson
    Proc Natl Acad Sci U S A 83:6692-6. 1986
  6. ncbi Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I
    S M Wahl
    Laboratory of Immunology, NIDR, NIH, Bethesda, MD 20892, USA
    Oral Dis 3:S64-9. 1997
  7. ncbi Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission
    K Pillay
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013, Republic of South Africa
    J Infect Dis 183:653-6. 2001
  8. pmc Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
    Carey Farquhar
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 186:1173-6. 2002
  9. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
  10. doi The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils
    Lars C Jacobsen
    The Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Leukoc Biol 83:1155-64. 2008

Research Grants

  1. STEVEN R MUMM; Fiscal Year: 2014
  2. Xianzhong Meng; Fiscal Year: 2015
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
  7. Vijay Sharma; Fiscal Year: 2015
  8. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
  9. Hua Su; Fiscal Year: 2016
  10. Jaime Chu; Fiscal Year: 2016

Patents

  1. Human cDNAs and proteins and uses thereof

Detail Information

Publications301 found, 100 shown here

  1. pmc Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease
    Emer P Reeves
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Biomed Res Int 2013:560141. 2013
    Secretory leukoprotease inhibitor (SLPI) is an anti-inflammatory protein present in respiratory secretions. Whilst epithelial cell SLPI is extensively studied, neutrophil associated SLPI is poorly characterised...
  2. pmc Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons
    Amit Chattopadhyay
    School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Infect Immun 72:1956-63. 2004
    ..Secretory leukocyte protease inhibitor (SLPI), a 12-kDa antiprotease, suppresses the growth of C. albicans in vitro...
  3. pmc The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane
    Bénédicte Py
    Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    PLoS ONE 4:e5006. 2009
    Secretory leukocyte protease inhibitor (SLPI) is secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid...
  4. ncbi Location of the protease-inhibitory region of secretory leukocyte protease inhibitor
    S P Eisenberg
    Synergen Inc, Boulder, Colorado 80301
    J Biol Chem 265:7976-81. 1990
    Secretory leukocyte protease inhibitor (SLPI) is a two-domain protein that inhibits a wide range of proteases including chymotrypsin, leukocyte elastase, and trypsin...
  5. pmc Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase
    R C Thompson
    Proc Natl Acad Sci U S A 83:6692-6. 1986
    ..The affinity of the inhibitor for leukocyte elastase is very high, suggesting a functional role for the protein in preventing elastase-mediated damage to oral and possibly other mucosal tissues...
  6. ncbi Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I
    S M Wahl
    Laboratory of Immunology, NIDR, NIH, Bethesda, MD 20892, USA
    Oral Dis 3:S64-9. 1997
    ..these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro...
  7. ncbi Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission
    K Pillay
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013, Republic of South Africa
    J Infect Dis 183:653-6. 2001
    ..In 60 HIV-1-infected women, concentrations of the innate mucosal protein, secretory leukocyte protease inhibitor (SLPI), were lower in vaginal fluid samples from 17 women whose babies became infected than in samples from ..
  8. pmc Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
    Carey Farquhar
    Departments of Medicine, Epidemiology, and Biostatistics, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 186:1173-6. 2002
    Secretory leukocyte protease inhibitor (SLPI), a protein found in saliva, breast milk, and genital secretions, is capable of inhibiting human immunodeficiency virus (HIV) type 1 in vitro...
  9. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
    ..whole saliva with antibodies raised against human lactoferrin (hLf), secretory leukocyte protease inhibitor (SLPI), and, to a lesser extent, MG2 (high-molecular-weight mucinous glycoprotein) reduced the HIV-1 inhibitory activity ..
  10. doi The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils
    Lars C Jacobsen
    The Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Leukoc Biol 83:1155-64. 2008
    The secretory leukocyte protease inhibitor (SLPI) re-establishes homeostasis at sites of infection by virtue of its ability to exert antimicrobial activity, to suppress LPS-induced cellular immune responses, and to reduce tissue damage ..
  11. doi 17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor
    Sanjay H Chotirmall
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Respir Crit Care Med 182:62-72. 2010
    ..An unexplained gender gap is observed in cystic fibrosis (CF). Females have poorer lung function, decreased survival, and earlier Pseudomonas colonization...
  12. pmc Enhanced secretory leukocyte protease inhibitor in human immunodeficiency virus type 1-infected patients
    A A Baqui
    Department of Oral Medicine, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    Clin Diagn Lab Immunol 6:808-11. 1999
    Secretory leukocyte protease inhibitor (SLPI) has been found to possess activity against the human immunodeficiency virus type 1 (HIV-1) in vitro at physiological concentrations...
  13. pmc Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers
    H Hocini
    Unité INSERM U430, Paris, France
    Clin Diagn Lab Immunol 7:515-8. 2000
    ..These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.
  14. ncbi Secretory leukocyte protease inhibitor: inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein
    Nancy R Shine
    Department of Microbiology, School of Dentistry, University of the Pacific, San Francisco, CA 94115, USA
    Bioorg Chem 30:249-63. 2002
    The ability of the salivary protein, secretory leukocyte protease inhibitor (SLPI), to inhibit human immunodeficiency virus-1 (HIV-1) infection in vitro has been reported previously and has led to the suggestion that SLPI may be partially ..
  15. pmc Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells
    Catherine M Greene
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Infect Immun 72:3684-7. 2004
    Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-kappaB activation...
  16. ncbi Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis
    Bettina Sehnert
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 50:2347-59. 2004
    b>Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases...
  17. ncbi Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1
    Michael C Velarde
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, 72202, USA
    Endocrinology 147:1969-78. 2006
    ..cells using Ishikawa human endocarcinoma cells and the P-responsive secretory leukocyte protease inhibitor (SLPI) gene...
  18. ncbi Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor
    J M Sallenave
    Department of Biochemistry, Edinburgh University Medical School
    Biol Chem Hoppe Seyler 372:13-21. 1991
    ..inhibitor (ESI) was purified from sputum of patients with chronic bronchitis and compared with mucus proteinase inhibitor (MPI, BrI) isolated, without the use of affinity chromatography on an enzyme, from non-purulent sputum ..
  19. ncbi Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement
    C C Tseng
    Divisions of Basic Sciences and of Restorative and Prosthodontic Sciences, New York University College of Dentistry, New York, NY 10010, USA
    FEBS Lett 475:232-6. 2000
    Previous studies have suggested that human salivary secretory leukocyte protease inhibitor (SLPI) inhibits HIV-1 by binding to a host cell surface protein of unknown identity...
  20. pmc Human immunodeficiency virus type 1 stimulates the expression and production of secretory leukocyte protease inhibitor (SLPI) in oral epithelial cells: a role for SLPI in innate mucosal immunity
    N K Jana
    School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Chapel Hill, NC 27599 7455, USA
    J Virol 79:6432-40. 2005
    ..We further hypothesized that secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, is a component of the host immune response to this virus...
  21. ncbi MMPI correlates of sleep and respiratory disturbance in obstructive sleep apnea
    J E Aikens
    University of Chicago, USA
    Sleep 22:362-9. 1999
    ..INTERVENTIONS: Not applicable. MEASUREMENTS AND RESULTS: Patients completed the MPI prior to overnight diagnostic polysomnography...
  22. ncbi [Therapy of lung diseases with antiproteases]
    C Vogelmeier
    Pneumologische Abteilung Klimikum Grosshadern,
    Pneumologie 48:57-62. 1994
    ..AAT) is the most important protease inhibitor of the human lung followed by the Secretory Leukoprotease Inhibitor (SLPI)...
  23. ncbi Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
    A Hagiwara
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 20:197-204. 1992
    ..levels were increased, and the brush border enzymes (gamma-glutamyl transpeptidase, GGT, and alkaline phosphatase, ALP) decreased...
  24. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991
    ..The aim of this work was to study possible relationships between serum TF, alkaline phosphatase activity (ALP), plasma insulin-like growth factor 1 (IGF-1) levels and rate of height increase in boys...
  25. ncbi Effect of aminohydroxypropylidene diphosphonate on the bone metabolism of patients with parathyroid adenoma
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:493-7. 1993
    ..Serum alkaline phosphatase (ALP) and osteocalcin, markers of osteoblast activity, decreased after APD administration...
  26. pmc Pharmacological activity of the C-terminal and N-terminal domains of secretory leukoprotease inhibitor in vitro
    K Masuda
    Institute for Biomedical Research, Teijin Limited, Tokyo, Japan
    Br J Pharmacol 115:883-8. 1995
    ..1. In order to characterize the physiological functions of the domain structure of secretory leukoprotease inhibitor (SLPI), the biological capacities of half-length SLPIs, (Ser1-Pro54)SLPI and (Asn55-Ala107)SLPI, were investigated and ..
  27. ncbi Raised plasma concentrations of parathyroid hormone related peptide in hypercalcemic multiple myeloma
    T Horiuchi
    Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Horm Metab Res 29:469-71. 1997
    ..We also measured serum levels of inorganic phosphorus (iP) and alkalinephosphatase activity (ALP). No significant differences in iP (3.2 +/- 0.4 vs. 4.0 +/- 2.2 mg/dl), ALP (150 +/- 28 vs...
  28. ncbi Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism
    M Kanzawa
    Department of Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 32:355-8. 2000
    ..before and one year after parathyroidectomy, as well as serum levels of calcium, phosphorus, alkaline phosphatase (ALP) and intact PTH were measured...
  29. doi The lower genital tract microbiota in relation to cytokine-, SLPI- and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH)
    Natalia Nikolaitchouk
    Department of Clinical Bacteriology, Gothenburg University, Gothenburg, Sweden
    APMIS 116:263-77. 2008
    ..with proinflammatory cytokines (IL-1 alpha, IL-1 beta, IL-6, IL-8), secretory leukocyte protease inhibitor (SLPI), and endotoxin in the cervicovaginal samples...
  30. ncbi The usefulness of biochemical bone markers in predicting the response of hormone replacement therapy in perimenopausal cigarette smoking healthy women
    M Cubrilo-Turek
    Clinics for Internal Medicine, General Hospital Sveti Duh, Zagreb, Croatia
    Coll Antropol 23:195-201. 1999
    ..in hormone replacement users (N = 35) and non-users (N = 28): serum total calcium (Ca), total alkaline phosphatase (ALP), procollagen I C-terminal propeptide (PICP), cros-linked carboxyterminal collagen I telopeptide (ICTP) and ..
  31. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
    ..Anti-PECAM-1 antibody suppressed both ALP+ CFU-f formation and ALP production under co-culture of the osteoblastic cell line and the PECAM-1+ endothelial ..
  32. ncbi [A case of AIDS complicated with liver tuberculosis]
    I Kawashima
    Department of Internal Medicine, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 74:984-8. 2000
    ..historicica, serum levels of gamma-GTP and ALP remained high and hepatosplenomegaly gradually increased. A liver biopsy was performed...
  33. ncbi Intense peripheral electrical stimulation differentially inhibits tail vs. limb withdrawal reflexes in the rat
    V V Romita
    Department of Psychiatry, McGill University, Montreal, Que, Canada
    Brain Res 720:45-53. 1996
    ..of the forelimb increased the latency of the withdrawal reflex to 70-100% of the maximum possible inhibition (MPI) during the stimulation. Inhibition persisted for more than 1 h after the end of stimulation...
  34. ncbi Alkaline phosphatase of cancerous larynx tissue in comparison with the placental enzyme. Biochemical and histochemical studies
    Z A al-Mudamgha
    Saddam College of Medicine, University of Baghdad, Iraq
    Acta Oncol 36:213-8. 1997
    ..A histochemical study of alkaline phosphatase (ALP) was carried out using the simultaneous azo coupling method, and biochemical studies were performed using disodium ..
  35. ncbi Clinical significance of serum total and heat-stable alkaline phosphatase in leukemia patients
    P S Patel
    Division of Research, Gujarat Cancer Society, New Civil Hospital Compound, Ahmedabad, India
    Tumori 79:352-6. 1993
    AIMS AND BACKGROUND: Variations in serum alkaline phosphatase (ALP) and placental-like (heat stable) alkaline phosphatase (PLAP) are found to be clinically useful in cancer patients...
  36. ncbi Comparison of two newly identified tumor markers (CAR-3 and DU-PAN-2) with CA 19-9 in patients with pancreatic cancer
    C Ferrara
    Istituto di Medicina Interna,
    Tumori 77:56-60. 1991
    ..Correlations were found between the behavior of all three markers and that of the cholestasis indices (ALP and GGT)...
  37. ncbi Automated and semiautomated analysis of rat alkaline phosphatase isoenzymes
    W E Hoffmann
    University of Illinois College of Veterinary Medicine, College of Veterinary Medicine, Urbana 61801, USA
    Toxicol Pathol 22:633-8. 1994
    A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential ..
  38. pmc Inhibition by recombinant SLPI and half-SLPI (Asn55-Ala107) of elastase and cathepsin G activities: consequence for neutrophil-platelet cooperation
    P Renesto
    , , Institut Pasteur, Paris, France
    Br J Pharmacol 108:1100-6. 1993
    1. The capacity of recombinant human secretory leukocyte proteinase inhibitor (SLPI) to inhibit human leukocyte elastase (HLE) and cathepsin G (Cat G) was investigated and compared with a recombinant truncated form (carboxyl-terminal ..
  39. ncbi Biochemical parameters as prognostic factors in prostatic adenocarcinoma
    S Vesalainen
    Department of Surgery, University of Kuopio, Finland
    Acta Oncol 34:53-9. 1995
    The serum levels of creatinine (CR), alkaline phosphatase (ALP), acid phosphatase (ACP) and tartrate inhibitable acid phosphatase (TIAP) were related to Gleason score, TM-category, disease progression and survival in 325 prostatic ..
  40. doi Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture
    Jon Power
    Bone Research Division, Department of Medicine, University of Cambridge, Cambridge, UK
    J Bone Miner Res 25:1867-76. 2010
    ..5 mm in diameter) with at least one canal staining for alkaline phosphatase (ALP), a marker of bone formation...
  41. doi Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor
    O Mehrpour
    Department of Forensic Medicine, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Hum Exp Toxicol 27:591-5. 2008
    Aluminum phosphide (AlP) is a solid fumigant widely used in Iran as a grain preservative...
  42. ncbi Effects of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells
    W H Mueller
    Zentrum Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
    J Cell Physiol 182:50-61. 2000
    Alkaline phosphatase (ALP) is a glycoenzyme that is highly expressed during carcinogenesis and is induced by retinoic acid (RA) in various cells...
  43. pmc Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin
    Ivan Arenas
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 285:12497-503. 2010
    ..Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP), have been shown to bind Cry1Ab, although their role in toxicity remains to be determined...
  44. ncbi [Studies on allelic zymogram of periodic Brugia malayi from Zhejiang Province]
    S Deng
    Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17:305-7. 1999
    ..malayi, most of them were homozygotes, however, two of them(MPI,MDH) were heterozygotes(7.4%)...
  45. ncbi Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice
    A K Srivastava
    Musculoskeletal Disease Center, JLP VA Medical Center, Loma Linda, CA, 92357, USA
    Bone 35:1086-94. 2004
    To examine the hypothesis that serum alkaline phosphatase (ALP) levels have a heritable component, we analyzed blood from two inbred strains of mice, MRL/MpJ and SJL, which exhibit 90% difference in total serum ALP activity (268+/-26 vs...
  46. ncbi Risk factors affecting metaphyseal irregularities in the radius and ulna of growing Newfoundland dogs
    C Trangerud
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    J Anim Sci 85:2437-44. 2007
    ..effects of litters, BW, circumferences of the distal radius and ulna (CDRU), and total serum alkaline phosphatase (ALP) concentrations. The study included 118 Newfoundland dogs (60 females, 58 males), derived from 32 litters...
  47. ncbi Monoclonal antibodies against tissue-nonspecific alkaline phosphatase. Report of the ISOBM TD9 workshop
    P Magnusson
    Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Biomedicine and Surgery, Linkoping University Hospital, Linkoping, Sweden
    Tumour Biol 23:228-48. 2002
    ..The evaluation included the following antigen forms: (a) commercially available preparations of human bone ALP (BALP) and liver ALP (LALP); (b) human BALP isoforms, B/I, B1 and B2; and (c) soluble secreted epitope-tagged ..
  48. ncbi Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae
    Juan F Santibanez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, Madrid, Spain
    Cardiovasc Res 77:791-9. 2008
    ..The aim of this work was to assess the location of ALK1 in endothelial caveolae as well as to study the role of caveolin-1 on the TGF-beta/ALK1 signalling pathway.
  49. ncbi Genotype-by-sex and environment-by-sex interactions influence variation in serum levels of bone-specific alkaline phosphatase in adult baboons (Papio hamadryas)
    L M Havill
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Bone 35:198-203. 2004
    ..we conducted a statistical genetic analysis of serum concentrations of bone-specific alkaline phosphatase (Bone ALP), a highly specific marker of osteoblast function that is elevated in persons with conditions like osteoporosis ..
  50. doi Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:2467-75. 2009
    ..The aim of this study was to evaluate the prevalence and to identify risk factors for abnormal LFTs in patients with IPAA and underlying IBD...
  51. ncbi Alkaline phosphatase isoenzymes in mouse plasma detected by polyacrylamide-gel disk electrophoresis
    Kazuhisa Hatayama
    Toxicology Department, Gotemba Laboratory, Bozo Research Center Inc, Japan
    J Toxicol Sci 36:211-9. 2011
    Plasma alkaline phosphatase (ALP) activity is frequently measured in toxicity studies...
  52. pmc Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
    Qi Hao
    University of California, San Francisco, Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Rm 3C 38, San Francisco, CA 94110, USA
    Am J Physiol Heart Circ Physiol 295:H2250-6. 2008
    Loss-of-function activin receptor-like kinase 1 gene mutation (ALK1+/-) is associated with brain arteriovenous malformations (AVM) in hereditary hemorrhagic telangiectasia type 2. Other determinants of the lesional phenotype are unknown...
  53. ncbi Alterations of blood analyses at relapse of osteosarcoma and Ewing's sarcoma
    E Hannisdal
    Department of Oncology, Norwegian Radium Hospital, Oslo
    Acta Oncol 29:585-7. 1990
    ..and thrombocyte counts, gamma glutamyltransferase (GT), lactate dehydrogenase (LD) and alkaline phosphatase (ALP). Sixteen relapsing patients diagnosed from 1970 to 1987 were eligible in each sarcoma group...
  54. ncbi Activity and practice of nuclear cardiology in the Czech Republic, 2001
    Milan Kaminek
    Department of Nuclear Medicine, University Hospital, Olomouc, I P Pavlova 6, 775 20 Olomouc, Czech Republic
    Eur J Nucl Med Mol Imaging 30:321-4. 2003
    Radionuclide myocardial perfusion imaging (MPI) has been on the rise in Europe and the USA...
  55. pmc Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology
    Laura B Lemke
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825, Cambridge, MA 02139, USA
    Infect Immun 77:2147-58. 2009
    ..bilis infected followed in 2 weeks by H. pylori and then evaluated at 6 and 11 months postinfection (mpi) for gastritis and premalignant lesions. Compared to H. pylori-infected mice, H. bilis/H...
  56. ncbi The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity
    Makoto Matsushita
    Department of Clinical Chemistry, Saitama Prefectural University Junior College, 820 Sannomiya, Koshigaya 343 8540, Japan
    Clin Chim Acta 319:49-55. 2002
    ..DEA and 2-ethylaminoethanol, EAE) have been widely used for the measurement of serum total alkaline phosphatase activity (ALP) in clinical laboratories, and the individual isozyme are activated differently by respective buffers.
  57. ncbi Molecular characterization of a PDZ-LIM protein in Atlantic salmon (Salmo salar): a fish ortholog of the alpha-actinin-associated LIM-protein (ALP)
    Øivind Andersen
    Institute of Aquaculture Research, P O Box 5010, N 1432 Aas, Norway
    J Muscle Res Cell Motil 25:61-8. 2004
    ..A full-length cDNA encoding the ortholog of the alpha-actinin-associated LIM protein (ALP) was isolated from white skeletal muscle of Atlantic salmon (Salmo salar)...
  58. ncbi [Interventional effect of platelet lysate on osteogenic differentiation of BMSCs in rats]
    Huiping Song
    Shanxi Provincial Tissue Bank, Taiyuan Shanxi, 030006, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:737-41. 2008
    ..To explore the interventional effect of platelet lysate (PL) on osteogenic differentiation of BMSCs by induction in rats in vitro...
  59. pmc Negative predictive value and potential cost savings of acute nuclear myocardial perfusion imaging in low risk patients with suspected acute coronary syndrome: a prospective single blinded study
    Jakob L Forberg
    Divisions of Emergency Medicine, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden
    BMC Emerg Med 9:12. 2009
    Previous studies from the USA have shown that acute nuclear myocardial perfusion imaging (MPI) in low risk emergency department (ED) patients with suspected acute coronary syndrome (ACS) can be of clinical value...
  60. doi Early predisposition to osteomalacia in Indian adults on phenytoin or valproate monotherapy and effective prophylaxis by simultaneous supplementation with calcium and 25-hydroxy vitamin D at recommended daily allowance dosage: a prospective study
    Geetha Krishnamoorthy
    Department of Biochemistry, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai 400 022, India
    Neurol India 58:213-9. 2010
    Long-term therapy with antiepileptic drugs (AED) may be associated with increased total serum alkaline phosphatase (ALP) levels and reduced serum calcium, inorganic phosphorous, and vitamin D levels...
  61. ncbi A cluster analysis of the multidimensional pain inventory
    L Walter
    University of New Hampshire
    Headache 31:476-9. 1991
    ..recruited from a headache clinic's biofeedback facility, were administered the Multidimensional Pain Inventory (MPI) for measuring the cognitive, behavioral, and affective dimensions of pain...
  62. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI...
  63. ncbi Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells
    S Watanabe
    Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Biol Chem 264:12611-9. 1989
    Alkaline phosphatase (ALP) in human choriocarcinoma cells (malignant trophoblasts) was characterized by its greater sensitivity to EDTA and L-leucine inhibition as compared with the placental isozyme...
  64. ncbi New parameters in identification of right ventricular myocardial infarction and proximal right coronary artery lesion
    Kurtulus Ozdemir
    Cardiology Department, Selcuk University Medical Faculty, Konya, Turkey
    Chest 124:219-26. 2003
    ..to find out the usefulness both of peak myocardial systolic velocity (Sm) and of the myocardial performance index (MPI) of the right ventricle measured by pulsed-wave tissue Doppler imaging (TDI) in assessing right ventricular function...
  65. ncbi Comparative inhibition of human alkaline phosphatase and diamine oxidase by bromo-levamisole, cimetidine and various derivatives
    T Metaye
    Department of Biochemistry, U E R of Medecine Pharmacy, Poitiers, France
    Biochem Pharmacol 37:4263-8. 1988
    ..are examined in vitro in order to investigate their comparative inhibition, towards alkaline phosphatase (ALP) from human liver and diamine-oxidase (DAO) from human placenta...
  66. ncbi Importance of the index of myocardial performance in evaluation of left ventricular function
    Sinan Dagdelen
    Kosuyolu Heart and Research Hospital, Istanbul, Turkey
    Echocardiography 19:273-8. 2002
    The index of myocardial performance (MPI) has been used as an easily obtainable parameter that reflects both systolic and diastolic functions of the myocardium and correlates closely with invasive measurements...
  67. ncbi Clinical phenotypes, ALK1 gene mutation and level of related plasma proteins in Chinese hereditary hemorrhagic telangiectasia
    Guang Sen Zhang
    Division of Hematology, Institute of Molecular Hematology, The Second Xiang Ya Hospital, Central South University, Changsha 410011, China
    Chin Med J (Engl) 117:808-12. 2004
    We determined the diagnosis of hereditary hemorrhagic telangiectasis (HHT) in a suspected HHT family, identified ALK1 gene mutation and established a gene diagnosis method of HHT...
  68. ncbi The effect of high-protein diets on coronary blood flow
    R M Fleming
    The Fleming Heart and Health Institute and the Camelot Foundation, Omaha, Nebraska 68114, USA
    Angiology 51:817-26. 2000
    ..Twenty-six people were studied for 1 year by using myocardial perfusion imaging (MPI), echocardiography (ECHO), and serial blood work to evaluate the extent of changes in regional coronary blood flow, ..
  69. ncbi Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France
    Gaetan Lesca
    Laboratoire de Genetique, Hopital Edouard Herriot, Lyon, France
    Hum Mutat 23:289-99. 2004
    ..The disease is caused by mutations of two genes: ENG and ALK1 (ACVRL1). We screened the coding sequence of ENG and ALK1 in 160 unrelated French index cases...
  70. ncbi Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 41:223-30. 2007
    ..We then measured the expression changes of bone marker genes, bone sialoprotein (BSP), alkaline phosphatase (ALP) and housekeeping genes, beta-actin and peptidylprolyl isomerase A (PPIA), by using real-time PCR in both the ..
  71. ncbi Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients
    Giuseppe Perinetti
    Department of Oral Sciences, University G D Annunzio, Chieti, Italy
    J Periodontol 79:1200-7. 2008
    ..One of these host enzymes is alkaline phosphatase (ALP), the GCF activity of which has been associated with periodontal inflammation...
  72. ncbi Increased liver enzymes in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
    Endocr J 56:601-8. 2009
    ..Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT), ..
  73. ncbi [Effect of various concentrations of platelet-rich plasma on osteogenic differentiation of skeletal muscle-derived stem cells]
    Liancheng Shan
    Department of Orthopaedics, Shanghai Sixth People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:991-6. 2009
    ..To investigate the effect of various concentration of platelet-rich plasma (PRP) on osteogenic differentiation of rabbit skeletal muscle-derived stem cells (SMSCs) cultured in vitro...
  74. doi Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease
    Hideyo Sugahara
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 65:699-704. 2009
    ..The aim of this study was to investigate the factors responsible for interindividual variability in the extent of interaction between FVX and alprazolam (ALP).
  75. ncbi Calciuria in children with juvenile chronic arthritis
    D Nemcova
    Department of Pediatrics, First Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:43-5. 1994
    ..12 patients with confirmed diagnosis of JCA basic biochemical indices of bone metabolism, were performed (S-Ca, P, ALP, U-Ca/U-creatinine, U-P)...
  76. ncbi Increased secretory leukoprotease inhibitor in patients with nonsmall cell lung carcinoma
    S Ameshima
    Department of Internal Medicine, Fukui Medical University, Fukui, Japan
    Cancer 89:1448-56. 2000
    ..that acute pulmonary inflammation, such as that observed in pneumonia, elevates secretory leukoprotease inhibitor (SLPI) levels in serum...
  77. doi Intra-aneurysm sac pressure in patients with unchanged AAA diameter after EVAR
    N V Dias
    Vascular Center Malmö Lund, Malmo University Hospital, Malmo, Sweden
    Eur J Vasc Endovasc Surg 39:35-41. 2010
    ..To study intra-aneurysm sac pressure and subsequent abdominal aortic aneurysm (AAA) diameter changes in patients without endoleaks that remain unchanged in AAA diameter more than 1 year after endovascular aneurysm repair (EVAR)...
  78. ncbi Secretory leukocyte protease inhibitor, but not alpha-1 protease inhibitor, blocks tryptase-induced bronchoconstriction
    R M Forteza
    Division of Pulmonary Diseases, University of Miami at Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Pulm Pharmacol Ther 14:107-10. 2001
    Alpha-1-protease inhibitor (alpha(1)-PI) and secretory leukocyte protease inhibitor (SLPI) are two natural airway serine protease inhibitors...
  79. ncbi Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality
    Charles DeRossi
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:5916-27. 2006
    b>MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis...
  80. doi Contrast stress echocardiography for the diagnosis of coronary artery disease in patients with chest pain but without acute coronary syndrome: incremental value of myocardial perfusion
    Nicola Gaibazzi
    Dipartimento del Cuore, Azienda Ospedaliero, Universitaria di Parma, Parma, Italy
    J Am Soc Echocardiogr 22:404-10. 2009
    ..Myocardial perfusion imaging (MPI) could prove effective in the risk stratification of patients in whom acute coronary syndromes are ruled out by ..
  81. doi Recent payment and utilization trends in radionuclide myocardial perfusion imaging: comparison between self-referral and referral to radiologists
    David C Levin
    Center for Research on Utilization of Imaging Services, Department of Radiology, Thomas Jefferson University Hospital and Jefferson Medical College, Philadelphia, PA 19107, USA
    J Am Coll Radiol 6:437-41. 2009
    The aim of this study was to examine the effects of self-referral by comparing recent trends in payments and utilization rates for radionuclide myocardial perfusion imaging (MPI) among radiologists and cardiologists between 1998 and 2006.
  82. doi Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study
    Fritz H Schroder
    Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BJU Int 106:182-7. 2010
    ..5 mg in the control of total serum alkaline phosphatase (S-ALP) levels in patients with prostate cancer...
  83. pmc Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets
    Serap Turan
    Marmara University, Department of Pediatric Endocrinology, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 3:7-11. 2011
    Serum alkaline phosphatase (ALP) levels show great variation with age and sex in children and adolescents. Additionally, different buffers used even in the same method cause variable results...
  84. ncbi Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution
    B J Knoll
    Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston 77025
    J Biol Chem 263:12020-7. 1988
    Three closely related alkaline phosphatase (ALP) genes reside on the long arm of chromosome 2 in man. One of these genes (the placental ALP-1) encodes the classic heat-stable placental alkaline phosphatase...
  85. ncbi Temporal and local appearance of alkaline phosphatase activity in early stages of guided bone regeneration. A descriptive histochemical study in humans
    U Stucki
    Department of Periodontology and Fixed Prosthodontics, University of Berne, School of Dental Medicine, Berne, Switzerland
    Clin Oral Implants Res 12:121-7. 2001
    Alkaline phosphatase (ALP) catalyzes the hydrolysis of phosphate esters and it seems to be a prerequisite for normal skeletal mineralization. Also, ALP is the most widely recognized marker of osteoblast phenotypes...
  86. ncbi Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity
    C M Gundberg
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510, USA
    Bone 31:703-8. 2002
    ..values of two bone formation markers, serum osteocalcin (Oc) and bone specific alkaline phosphatase (bone ALP), were compared by age, gender, and race or ethnicity using serum obtained from a subsample of blacks, whites, and ..
  87. ncbi Myocardial perfusion imaging in Denmark: activity from 1997 to 2001 and current practice
    Claus Leth Petersen
    Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital H S, University of Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 30:137-40. 2003
    ..sent to all departments of nuclear medicine in Denmark (n=20) asking for details of myocardial perfusion imaging (MPI), including the number of patients examined each year from 1997 to 2001 and the current clinical and technical ..
  88. ncbi Does the myocardial performance index affect pulmonary artery pressure in patients with mitral stenosis? A tissue Doppler imaging study
    Kuruluş Ozdemir
    Department of Cardiology, Faculty of Medicine, Selcuk University, Konya, Turkey
    Echocardiography 20:249-56. 2003
    ..So, we analyzed whether the left and right ventricular myocardial performance index (MPI) correlated with the PAP.
  89. ncbi Esophageal dysfunction in patients with atypical chest pain investigated with esophageal scintigraphy and myocardial perfusion imaging: an outcome study
    Douglas Howarth
    Hunter Imaging Group, Warners Bay, New South Wales, Australia
    J Nucl Cardiol 10:490-7. 2003
    The objectives of this study were to determine the role of esophageal scintigraphy (ES) and myocardial perfusion imaging (MPI) in patients with atypical chest pain investigated for ischemic heart disease (IHD).
  90. ncbi Dobutamine myocardial scintigraphy for the prediction of cardiac events after heart transplantation
    Marcus Hacker
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Nucl Med Commun 26:607-12. 2005
    ..Single photon emission computed tomography-myocardial perfusion imaging (SPECT-MPI) has been shown to be a useful and cost-effective non-invasive method in patients with known or suspected coronary ..
  91. ncbi Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis
    S W Cox
    Department of Periodontology, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London, UK
    J Periodontal Res 41:477-85. 2006
    ..Our study investigated the regulation of elastase activity by secretory leukocyte protease inhibitor (SLPI) and the possible action of another GCF protease on this protective salivary component.
  92. pmc Usefulness of the comprehensive geriatric assessment in older patients with upper gastrointestinal bleeding: a two-year follow-up study
    Alberto Pilotto
    Geriatric Unit and Gerontology and Geriatrics Research Laboratories, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dig Dis 25:124-8. 2007
    ..The potential usefulness of standardized comprehensive geriatric assessment (CGA) in evaluating treatment and follow-up of older patients with upper gastrointestinal bleeding is unknown...
  93. ncbi Acute effect of transcatheter closure on right ventricular function in patients with atrial septal defect assessed by tissue Doppler imaging
    Jiandong Ding
    Department of Cardiology, Zhongda Hospital and School of Clinical Medicine, Southeast University, Nanjing, China
    Acta Cardiol 64:303-9. 2009
    ..The Doppler myocardial performance index (MPI) may provide a method of assessing function in these patients...
  94. pmc Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism
    Nelson Osses
    Centro de Regulación Celular y Patología, Centro de Regeneración y Envejecimiento, Departamento de Biologia Celular y Molecular, MIFAB, Pontificia Universidad Catolica de Chile, Santiago, Chile
    BMC Cell Biol 10:73. 2009
    ..We attempt to address if ECM also plays a role in the osteogenic differentiation of skeletal muscle cells...
  95. pmc Multidimensional Prognostic Index based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure
    Alberto Pilotto
    Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Circ Heart Fail 3:14-20. 2010
    ..The aim of this study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure.
  96. ncbi [Influence of co-culturing vascular endothelial cells and adipose-derived stromal cells on osteogenic differentiation in vitro]
    Fuke Wang
    Department of Head and Neck Surgery, the 1st Affiliated Hospital of Kunming Medical College, Kunming Yunnan, 650032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:399-405. 2010
    ....
  97. ncbi Bone and mineral metabolism in transient hyperphosphatasaemia
    S Kutilek
    Department of Pediatrics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:47-51. 1994
    Transient hyperphosphatasaemia (TH) is a benign disorder characterized by transient elevation of S-ALP activity not exceeding duration of 4 months in children under 5 years of age, with elevated activity of bone isoenzymes of ALP with no ..
  98. ncbi The effects of aerobic exercise on migraine
    D M Lockett
    Department of Psychology, Carleton University, Ottawa, Ont, Canada
    Headache 32:50-4. 1992
    ..the Pain-Severity, Affective-Distress, and Support scales of the West Haven-Yale Multidimensional Pain Inventory (MPI)...
  99. ncbi Calvarial "doughnut lesions": clinical spectrum of the syndrome, report on a case, and review of the literature
    D Baumgartner
    Department of Pediatrics, University of Innsbruck, Austria
    Am J Med Genet 99:238-43. 2001
    Many pathologic fractures, lumps on the head, elevated serum alkaline phosphatase (ALP) levels, and dental caries are the main characteristics of the rare autosomal dominantly inherited calvarial "doughnut lesions" (MIM 126550)...
  100. ncbi Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation
    A Suzuki
    Division of Bone Diseases, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Bone 30:91-8. 2002
    ..p38 only marginally influenced proliferation, but appeared to be critical for the control of alkaline phosphatase (ALP) expression in differentiating cells...
  101. ncbi Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA
    Ron A Deckelbaum
    Department of Medicine and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2
    J Cell Sci 115:3015-25. 2002
    ..Markers of chondrocyte differentiation [alkaline phosphatase (ALP) activity, and type II (Col2a1) and type X collagen (Col10a1) expression] were enhanced by overexpression of Ihh or ..

Research Grants65

  1. STEVEN R MUMM; Fiscal Year: 2014
    ..The patient had never been diagnosed with HPP, although her serum ALP was low (26 U/L, Nl 32 - 116 U/L)...
  2. Xianzhong Meng; Fiscal Year: 2015
    ..a major role in TLR4-induced osteogenic responses, characterized by expression of Runx2, alkaline phosphatase (ALP) and osteopontin...
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
    ..are recruited to the leading edge where adenosine is generated by CD39/E- NTPDase1 and alkaline phosphatase (ALP)...
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..We and others have provided evidence that MV phosphatases, including alkaline phosphatase (ALP), and ATPase are involved in MV mineralization...
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
    ..The molecule is identified as the cell-surface enzyme alkaline phosphatase (ALP). A prime focus of this project is to understand the role of ALP in guiding migrating embryonic cells...
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
    ..the bone forming potential of the osteoblasts is in direct proportion to the number of alkaline phosphatase (ALP) positive CFU-F...
  7. Vijay Sharma; Fiscal Year: 2015
    ..Myocardial perfusion imaging (MPI), a versatile tool in clinical diagnosis, plays an important role in the noninvasive assessment of coronary artery ..
  8. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..While reduced expression of either Endoglin (ENG) or Activin receptor-like kinase 1 (ALK1) has shown to be associated HHT, the precise pathogenetic mechanisms underlying HHT remain elusive;and thus, while ..
  9. Hua Su; Fiscal Year: 2016
    ..We use viral-mediated focal brain VEGF stimulation of mice with either endoglin (ENG) or activin-like kinase 1 (ALK1) haploinsufficiency. These animals display dysmorphic and enlarged microvascular structure...
  10. Jaime Chu; Fiscal Year: 2016
    ..Mutation of mannose-6-phosphate isomerase (MPI) causes the "gastrointestinal type" of CDG...
  11. ALAN BRENT PACKARD; Fiscal Year: 2014
    ..Myocardial perfusion imaging (MPI) is the most commonly performed nuclear medicine procedure performed in adults;nearly 60% of all nuclear medicine ..
  12. Carbohydrate Deficient Glycoprotein Syndromes: Models and Therapy
    Hudson H Freeze; Fiscal Year: 2013
    ..CDG-Ib patients have insufficient phosphomannose isomerase (MPI, Fru-6-P_>Man-6-P) activity and develop liver dysfunction, fibrosis, failure to thrive, protein-losing ..
  13. Interrogation of the Cellular Pathogenesis of Pulmonary Hypertension
    Larissa A Shimoda; Fiscal Year: 2012
    ..of the TGF beta superfamily pathways, bone morphogenetic protein receptor II (BMPR II) and the TGF-beta receptor I, ALK1, have been implicated in the pathogenesis of PH...
  14. Yucheng Yao; Fiscal Year: 2016
    ..and Matrix Gla Protein (MGP), a BMP antagonist, regulate the expression of the activin-like kinase receptor 1 (ALK1), essential in angiogenesis...
  15. Shuang Liu; Fiscal Year: 2014
    ....
  16. WADE HAMPTON MARTIN; Fiscal Year: 2014
    ..that composite findings of arm ergometer exercise ECG stress testing, with selective myocardial perfusion imaging (MPI) in a subset of patients such as those with highly abnormal resting ECGs or blunted hemodynamic responses, provides ..
  17. Xiaobin Wang; Fiscal Year: 2014
    ..outcomes, including (1) hormone dysfunction: reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP);(2) menstrual disorders;(3) infertility;(4) EPL and SAB;and (5) adverse birth ..
  18. Francesca Tentori; Fiscal Year: 2015
    ..These resources will be complemented by those at VUMC, including close mentorship by Dr. T. Alp Ikizler, interactions with other patient-oriented researchers and clinicians, and a vibrant scientific environment...
  19. Kelly A Birdwell; Fiscal Year: 2015
    ..My CTSA mentor, Dr. T. Alp Ikizler, is an internationally recognized leader on the metabolic complications of kidney disease and expert in the ..
  20. Mary Jackson; Fiscal Year: 2016
    ..Matrix-Assisted Laser desorption/ionization time of flight;Manp, mannopyranosyl;ManT, mannosyltransferase;MPI, mannosylated phosphatidylinositol;MS, mass spectrometry;myo-Ins, myo-inositol;ORF, open reading frame;investigator,..
  21. Ayman Al-Hendy; Fiscal Year: 2014
    ..Four targeted adenoviral vectors expressing luciferase gene as a marker (Ad5-RGD-luc, Ad5-CAV2- luc, Ad5-SLPI-luc, and Ad5-MSLN-CRAD-luc) will be directly delivered into the uterine fibroid tumors of the Eker rat, and their ..
  22. Three-dimensional cardiac accelerometry for cardiac monitoring
    Michael J Russell; Fiscal Year: 2010
    ..and electrocardiography (ECG), ultrasound (echocardiography, ECHO) and nuclear myocardial perfusion imaging (MPI) are the modalities commonly used for detecting ischemia and cardiac wall motion abnormalities...
  23. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010
    ..with CVD risk in insulin resistant individuals who express components of the atherogenic lipoprotein phenotype (ALP)...
  24. Caroline M Mitchell; Fiscal Year: 2014
    ..and/or production of antimicrobial peptides(beta-defensins, cathelicidin, secretory leukocyte protease inhibitor[SLPI], lactoferrin);2) that some individuals are more vulnerable to colonization due to low baseline levels of those ..
  25. Exploration of novel pan-HPV treatments to block development of AIDS-associated c
    Wijbe Martin Kast; Fiscal Year: 2010
    ..Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor found in mucosal fluids of the genital tract and has been shown to inhibit ..
  26. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..on the cellular and molecular mechanisms whereby progranulin (PGRN) and secretory leukocyte protease inhibitor (SLPI), two host-derived anti-inflammatory proteins, regulate the synthesis of IL-10 in macrophages in vitro and protect ..
  27. James K Min; Fiscal Year: 2016
    ..Physiologic stress testing by myocardial perfusion imaging (MPI) is the traditional method for evaluating CAD, and identifies ischemia but not stenoses...
  28. Monodispersed Biocompatible Magnetic Nanoprobes for Improved Diagnostic Imaging
    KANNAN MANJAPRA KRISHNAN; Fiscal Year: 2011
    ..Our goal is to use Magnetic Particle Imaging (MPI), a new medical imaging technology recently introduced by Philips that uses the magnetic relaxation of magnetite ..
  29. Grant T Gullberg; Fiscal Year: 2014
    ..Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is now the most widely applied noninvasive method for the detection and risk stratification of coronary artery ..
  30. DENNIS LARRY KOLSON; Fiscal Year: 2015
    ..We are proposing a dual-investigator MPI study (Kolson, Aldvoni) to investigate a novel drug, dimethyl fumarate, (DMF, Fumaderm(R)), now in a phase III ..
  31. Cellular Mechanisms of Neuropathology in Parkinson's Disease
    John J Shacka; Fiscal Year: 2013
    ..The autophagy- lysosome pathway (ALP) is an important intracellular degradation and recycling pathway and a compromise in ALP function promotes the ..
  32. Jacqui Smith; Fiscal Year: 2015
    ..PSID), the American Time Use Survey's (ATUS) new well-being module, and the American Life Panel's (ALP) DRM...
  33. Deep Brain Stimulation Array for Neuromodulation
    Rio J Vetter; Fiscal Year: 2013
    ..This project will be directed by NeuroNexus with pre-clinical testing conducted at MPI Research, Inc. and the University of Michigan...
  34. Nam Y Lee; Fiscal Year: 2014
    ..ligands exert their regulatory effects through the endothelial cell specific TGF-[unreadable] receptor complex, ALK1 (type I receptor) and endoglin (co-receptor), along with the ubiquitous type I TGF-[unreadable] receptor, ALK5, to ..
  35. Pietro P Sanna; Fiscal Year: 2016
    ..The present multiple principal investigator (MPI) project will involve 2 components: 1) The Scripps Research Institute (TSRI) component will carry out the animal ..
  36. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP) in women and abnormalities of LH, FSH, TSH, SHBG, inhibin-B and testosterone ..
  37. RICHARD DENNIS WADDELL; Fiscal Year: 2015
    ..training will focus on the research support needs identified at MUHAS via the MUHAS-UCSF Academic Learning Program (ALP), including grant application preparation and submission, pre- and post-award management, financial management, ..
  38. RESCUE: Randomized Evaluation of Patients with Stable Angina Comparing Utilizatio
    Arthur E Stillman; Fiscal Year: 2010
    ..This is not the case for the more traditional single photon emission tomography myocardial perfusion imaging (SPECT MPI) where patients with a positive test for CAD will require invasive angiography to identify potential left main ..
  39. Emiko Mizoguchi; Fiscal Year: 2015
    ..Interestingly, they developed both in antigen-independent manner and in SLPI (secretory leukocyte protease inhibitor) and BAFF (receptor of B cell activation factor from the TNF family)-..
  40. Enhancing Hawaii Hospital Information Content
    Todd B Seto; Fiscal Year: 2010
    ..disease severity and clinical performance;2) Build on our preliminary work developing a Master Patient Identifier (MPI) to link patients across hospitals throughout the state, by extending our work to include newborns, and creating a ..
  41. Innate Resistance to Mucosal HSV Infection in Humans
    Christine M Posavad; Fiscal Year: 2010
    ..peptides and proteins in the mucosal samples with a focus on defensins, secretory leukocyte protease inhibitor (SLPI), lactoferrin and lysozyme, mediators linked to defense against HSV infection...
  42. Ginette Serrero; Fiscal Year: 2014
    ..of PGRN by a proteolytic cleavage stimulated by elastase and blocked by secretory leucocyte protease inhibitor SLPI. Recent evidence suggests that both PGRN and grns may directly influence neurodegenerative diseases process, such ..
  43. Hongmei Zhang; Fiscal Year: 2014
    ..Dr. Zhang has rich experience in statistical modeling [1R03HL095429, Zhang (MPI)]...
  44. Michael L Hines; Fiscal Year: 2016
    ..NEURON already supports thread and MPI styles of parallelism for spike coupled networks, gap junctions, and distributed cable models of individual cells, ..
  45. Sarjeet S Gill; Fiscal Year: 2016
    ..Our research showed Aedes receptor proteins include cadherin, alkaline phosphatases (ALP), and aminopeptidases (APNs)...
  46. KANNAN MANJAPRA KRISHNAN; Fiscal Year: 2014
    ..PA-12-089), LodeSpin Labs (LSL) is developing a magnetic nanoparticle tracer for use in Magnetic Particle Imaging (MPI), a disruptive new medical imaging technology currently being developed as a safe, effective and quantitative ..
  47. William C Nichols; Fiscal Year: 2016
    ..EBV transformed peripheral blood lymphocytes, and plasma;2) Generate both genome wide SNP genotype data and BMPR2/ALK1 sequence/MLPA data on 2500 patients enrolled in the bank...
  48. Interaction between HSV-2 and the vaginal microbiome in the female genital tract
    CHRISTINE MICHELLE JOHNSTON; Fiscal Year: 2012
    ..e.secretory leukocyte protease inhibitor, SLPI) and that these changes result in fluctuations in the vaginal microbiome which predispose women to develop BV...
  49. Measuring Left Ventricular Dyssynchrony from ECG-gated Myocardial Perfusion SPECT
    Ji Chen; Fiscal Year: 2012
    ..phase analysis (MHPA) of ECG-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) study and by integrating this evaluation of LV dyssynchrony to our established quantification of myocardial ..
  50. Anti-HIV activity in genital tract secretions of postmenopausal women
    Mimi Ghosh; Fiscal Year: 2013
    ..Specifically we will determine the levels of protective endogenous anti-HIV factors (SLPI, Elafin, MIP3a/CCL20 and human beta defensin 2 (HBD2)) in genital tract secretions of pre- and postmenopausal women ..
  51. Hormone Regulation of Human Anti-HIV Molecules in the Female Reproductive Tract
    Jack E Bodwell; Fiscal Year: 2010
    ..of Vulnerability concept integrates the biology of the lower FRT with the recent finding that molecules (Elafin, SLPI, HDB2/3, MIP3alpha, etc.) of the innate immune system have significant anti-HIV activity...
  52. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2002
    ..and microcolony formation are potentiated by a host protein called secretory leukocyte protease inhibitor (SLPI)...
  53. Development and Maintenance of SPIDER Software for Electron Microscopy Imaging
    ArDean Leith; Fiscal Year: 2012
    ..by implementing new alignment and back-projection methods, off-loading computations to GPUs, and adding parallel MPI I/O...
  54. Comprehensive Analysis of Data from Testing the Re-engineered Hospital Discharge
    VEERAPPA CHETTY; Fiscal Year: 2009
    ..ROCR: Visualizing the performance of scoring classifiers". R package version 1.0-2. http://rocr.bioinf.mpi-sb.mpg.de/ Outcomes: We will publish five papers as listed 1.) risk scores and Intervention effect;2...
  55. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2002
    ..Recent molecular cloning studies have identified actinin-associated LIM protein (ALP), which is a novel component of the muscle cytoskeleton...
  56. Zhihua Jiang; Fiscal Year: 2015
    ..A primary mechanism that dictates TGF-2 specificity is the activation of its type I receptors Alk1 or Alk5...
  57. PEPTIDE INDUCTION OF POSITIVE SELECTION
    Kristin A Hogquist; Fiscal Year: 2010
    ..One of these involves the TGF[unreadable]/BMP family receptors, Endoglin and ALK1. These two proteins form an alternate receptor for TGF[unreadable], and we propose to test if this is critical to ..
  58. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..with (1) hormone dysfunction including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP); (2) menstrual disorders; (3) reduced fecundability; and (4) adverse ..
  59. Mireille Jacobson; Fiscal Year: 2014
    ..on the actual and perceived financial risk associated with health spending from the RAND American Life Panel (ALP)...
  60. FY 2013 Contract HHSN271201300012C, SBIR-1, Topic 003, Automated Instrument for C
    Jimmy Lu; Fiscal Year: 2013
    ..proposes to construct a cell-based high throughput assay that measures chemical toxicity using a novel dye, m-MPI. This dye was engineered to overcome many of the drawbacks of current dyes used to measure mitochondrial membrane ..
  61. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2007
    ..and microcolony formation are potentiated by a host protein called secretory leukocyte protease inhibitor (SLPI)...
  62. Jill S Halterman; Fiscal Year: 2016
    ..will be matched into 6 pairs and then randomly assigned to either the Multifaceted Prompting Intervention (MPI) or usual care...
  63. Computational Biology Cluster (CBC)
    James S Coleman; Fiscal Year: 2010
    ..new Intel Nehalem technology, and equipped with hybrid InfiniBand/GigE interconnect to support both tightly coupled MPI and loosely coupled high-throughput computations - a mix typically found in today's biomedical and bio-..
  64. Antibody- and peptide-inhibitors of quorum sensing
    Kim Janda; Fiscal Year: 2004
    ..Our proposed work includes the following aims: (1) synthesis of quorum sensing peptides and analogs from all 4 AlP subgroups of S...
  65. Production of the anti-HIV protein SLPI in plants
    David Lee; Fiscal Year: 2007
    ..Low-Cost Production Method for a Human Anti-HIV Protein SUMMARY: The human secretory leukocyte protease inhibitor (SLPI) is an 11...

Patents1

  1. Human cDNAs and proteins and uses thereof
    Patent Number: WO03046180-A2; Date:2003-06-05