SLC36A1

Summary

Gene Symbol: SLC36A1
Description: solute carrier family 36 member 1
Alias: Dct1, LYAAT1, PAT1, TRAMD3, proton-coupled amino acid transporter 1, lysosomal amino acid transporter 1, proton/amino acid transporter 1, solute carrier family 36 (proton/amino acid symporter), member 1
Species: human

Top Publications

  1. pmc Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 159:1339-53. 2010
  2. pmc An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 298:E1011-8. 2010
  3. pmc Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Physiol 546:349-61. 2003
  4. ncbi Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)
    Catriona M H Anderson
    Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 204:604-13. 2005
  5. pmc Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
    Madlen Dorn
    Institute of Biochemistry Biotechnology, Faculty of Science I, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    J Biol Chem 284:22123-32. 2009
  6. pmc Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
    S Heublein
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Oncogene 29:4068-79. 2010
  7. pmc Identification and characterization of a lysosomal transporter for small neutral amino acids
    C Sagne
    Institut National de la Santé et de la Recherche Médicale U 513, CHU Henri Mondor, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Proc Natl Acad Sci U S A 98:7206-11. 2001
  8. ncbi Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
  9. ncbi The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons
    Christopher C Wreden
    Department of Neurology and Physiology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 23:1265-75. 2003
  10. ncbi H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
    Catriona M H Anderson
    Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK
    Gastroenterology 127:1410-22. 2004

Research Grants

  1. Paul K Herman; Fiscal Year: 2016
  2. Genetic Models for Disorders of Acid-Base Transport
    GARY EDWARD SHULL; Fiscal Year: 2013
  3. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
  4. Mouse Models for Ion Homeostasis Defects in Heart
    Gary E Shull; Fiscal Year: 2010
  5. FAYEZ KHALAF GHISHAN; Fiscal Year: 2015
  6. MRNA DECAPPING IN YEAST
    ROY R PARKER; Fiscal Year: 2013
  7. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
  8. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
  9. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
  10. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001

Scientific Experts

Detail Information

Publications147 found, 100 shown here

  1. pmc Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 159:1339-53. 2010
    ..Oral administration of ALA has been used in patients with prostate and bladder cancer. The present aim was to investigate the mechanism of intestinal absorption of ALA and its transport via the amino acid transporter SLC36A1.
  2. pmc An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, Sealy Center on Aging, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 298:E1011-8. 2010
    ..transporter (LAT1), CD98, sodium-coupled neutral AA transporter (SNAT2), and proton-coupled amino acid transporter (PAT1) mRNA expression at 1 h (P < 0...
  3. pmc Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Physiol 546:349-61. 2003
    ..The cloned hPAT1 consists of 476 amino acids and exhibits 85 % identity with rat PAT1. Among the various human tissues examined by Northern blot, PAT1 mRNA was expressed most predominantly in the ..
  4. ncbi Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)
    Catriona M H Anderson
    Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 204:604-13. 2005
    ..This carrier, hPAT1 (human Proton-coupled Amino acid Transporter 1) or SLC36A1, has been identified recently at the molecular level and hPAT1 protein is localised to the brush border membrane ..
  5. pmc Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
    Madlen Dorn
    Institute of Biochemistry Biotechnology, Faculty of Science I, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    J Biol Chem 284:22123-32. 2009
    The proton-coupled amino acid transporter 1 (PAT1, SLC36A1) mediates the uptake of small neutral amino acids at the apical membrane of intestinal epithelial cells after protein digestion...
  6. pmc Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
    S Heublein
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Oncogene 29:4068-79. 2010
    ..In this study, we show the two human PATs that are widely expressed in normal tissues and cancer cell lines, namely PAT1 and PAT4, behave similarly to fly PATs when expressed in Drosophila...
  7. pmc Identification and characterization of a lysosomal transporter for small neutral amino acids
    C Sagne
    Institut National de la Santé et de la Recherche Médicale U 513, CHU Henri Mondor, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Proc Natl Acad Sci U S A 98:7206-11. 2001
    ..Homology searching in eukaryotic genomes suggests that LYAAT-1 defines a subgroup of lysosomal transporters in the amino acid/auxin permease family...
  8. ncbi Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Biol Chem 277:22966-73. 2002
    ..Phenotypically, the PAT1 transporter possesses the same functional characteristics as the previously described proton-dependent amino acid ..
  9. ncbi The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons
    Christopher C Wreden
    Department of Neurology and Physiology, University of California San Francisco School of Medicine, San Francisco, California 94143 0435, USA
    J Neurosci 23:1265-75. 2003
    Recent work has identified a lysosomal protein that transports neutral amino acids (LYAAT1)...
  10. ncbi H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
    Catriona M H Anderson
    Faculty of Medical Sciences, nUniversity of Newcastle Upon Tyne, Newcasttle Upon Tyne, UK
    Gastroenterology 127:1410-22. 2004
    ..the recently isolated complementary DNA hPAT1 (human proton-coupled amino acid transporter 1), or solute carrier SLC36A1, represents the imino acid carrier; the Na(+) -dependent imino acid transport function measured at the brush-..
  11. pmc Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2)
    David J Kennedy
    Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Br J Pharmacol 144:28-41. 2005
    ..in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e...
  12. pmc Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides
    Louisa Benboudjema
    Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Virol 77:9192-203. 2003
    ..host targets for the Us11 protein, we searched for cellular proteins that interact with Us11 and have identified PAT1 as a Us11-binding protein according to multiple, independent experimental criteria...
  13. ncbi Regulation of meiosis in fission yeast
    M Yamamoto
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Cell Struct Funct 21:431-6. 1996
    ..To initiate meiosis in S. pombe, a protein kinase encoded by pat1 (also called ran1) should be inactivated...
  14. ncbi Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2
    Zhong Chen
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 304:747-54. 2003
    ..The cDNA codes for a protein of 481 amino acids with 72% identity (over 449 amino acids) with rat PAT1. Tissue expression studies demonstrate that mRNA abundance is generally low with highest levels being detected in ..
  15. ncbi Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers
    Raquel Martín-Venegas
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, 08028 Barcelona, Spain
    J Nutr 137:49-54. 2007
    ..with L-Ala, beta-Ala, D-Pro, betaine, or glycyl-sarcosine excluded the participation of systems proton amino acid transporter 1 and peptide transporter 1...
  16. pmc Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine
    Catriona M H Anderson
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    J Pharmacol Exp Ther 332:220-8. 2010
    ..between ALA and GABA led us to test the hypothesis that the H(+)-coupled amino acid transporter PAT1 (SLC36A1) will contribute to luminal ALA uptake...
  17. ncbi Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct
    Hiroshi Ishiguro
    Laboratory of Human Nutrition, Nagoya Univ Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G447-55. 2007
    The role of Slc26a6 (PAT1) on apical Cl-/HCO3- exchange and bicarbonate secretion in pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice...
  18. ncbi Transport of L-proline, L-proline-containing peptides and related drugs at mammalian epithelial cell membranes
    M Brandsch
    Membrane Transport Group, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
    Amino Acids 31:119-36. 2006
    ..The amino acid transporter PAT1, expressed in intestine, kidney, brain and other organs, mediates the uptake of proline and derivatives in a pH ..
  19. ncbi Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis
    Zhe Peng
    Program in Molecular and Cellular Biology, State University of New York Health Science Center at Brooklyn, Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, Brooklyn, NY 11203, USA
    Curr Genet 43:178-85. 2003
    Ran1/Pat1 kinase and cAMP-dependent protein kinase (PKA) regulate sexual differentiation in Schizosaccharomyces pombe. A reduction in the activity of both enzymes is a prerequisite for meiosis...
  20. ncbi PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle
    R Lin
    Verna and Marrs McLean Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Cells 1:923-42. 1996
    ..Histone acetylation has been shown to play a role in transcription regulation, histone deposition and histone displacement during spermatogenesis, although no known histone acetyltransferase is essential...
  21. pmc PAT1, a new member of the GRAS family, is involved in phytochrome A signal transduction
    C Bolle
    Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Genes Dev 14:1269-78. 2000
    ..The PAT1 gene encodes a cytoplasmic protein of 490 amino acids with sequence homologies to the plant-specific GRAS ..
  22. ncbi Negative regulatory regions of the PAT1 promoter of Hz-1 virus contain GATA elements which associate with cellular factors and regulate promoter activity
    H H Chen
    Institute of Biotechnology and Department of Biology, National Cheng Kung University, Tainan 701, Taiwan
    J Gen Virol 82:313-20. 2001
    The persistence-associated transcript 1 (PAT1) is actively expressed during persistent infection with Hz-1 virus, while transcription of the rest of the viral genes is shut down...
  23. ncbi Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine
    Zhaohui Wang
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 282:G573-9. 2002
    ..include downregulated in adenoma (DRA or SLC26A3), pendrin (PDS or SLC26A4), and the putative anion transporter (PAT1 or SLC26A6) has recently been identified...
  24. doi Co-operative versus independent transport of different cargoes by Kinesin-1
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Traffic 9:725-41. 2008
    ..chain (KLC) subunit, namely the c-Jun NH(2)-terminal kinase-interacting proteins (JIPs) 1 and 3, Kidins220/ARMS and PAT1. Overexpression of individual cargo proteins in differentiated CAD cells resulted in mislocalization of the ..
  25. pmc Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    J Cell Biochem 105:454-66. 2008
    SLC26A6 (putative anion transporter 1, PAT1) has been shown to play an important role in mediating the luminal Cl(-)/OH(-)(HCO(3)(-)) exchange process in the intestine...
  26. pmc Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis
    Peter R Boag
    Joslin Diabetes Center, Harvard Stem Cell Institute, and 2Department of Pathology, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 182:543-57. 2008
    ..The P body protein Dhh1 inhibits translation and promotes decapping-mediated mRNA decay together with Pat1 in yeast, and has been implicated in mRNA storage in metazoan oocytes...
  27. ncbi The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe
    M Sipiczki
    Department of Genetics, L K University, Debrecen, Hungary
    Mol Gen Genet 213:529-34. 1988
    ..I found that the ste1, ste3 and ste8 genes act very early in the sexual development, presumably before the pat1-controlled conjugation-specific event...
  28. pmc Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis
    A Matsuyama
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Genetics 155:539-49. 2000
    ..The temperature-sensitive pat1-114 mutant underwent ectopic conjugation at the semirestrictive temperature when its genetic background was ste7(+),..
  29. ncbi A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe
    Akio Nakashima
    Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, 422 8539, Shizuoka, Japan
    Curr Genet 49:403-13. 2006
    ..b>Pat1 protein kinase negatively controls meiosis, and a temperature-sensitive mutant of pat1, pat1-114, initiates meiosis ..
  30. pmc Isolation of a mammalian homologue of a fission yeast differentiation regulator
    H Yamamoto
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell Biol 19:3829-41. 1999
    ..By using the phenotypic suppression of the S. pombe temperature-sensitive pat1 mutant that commits lethal haploid meiosis at the restrictive temperature, we have cloned ROD1, a functional ..
  31. ncbi SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney
    Minna Kujala
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Nephron Exp Nephrol 101:e50-8. 2005
    The anion transporters SLC26A6 (PAT1) and SLC26A7, transporting at least chloride, oxalate, sulfate and bicarbonate, show a distinct expression and function in different mammalian species...
  32. pmc Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways
    Stephane Hausmann
    Department of Microbiology and Molecular Medicine, University of Geneva, CH1211 Geneva, Switzerland
    J Biol Chem 283:31706-18. 2008
    ..analysis also highlighted synthetic interactions of Tgs1 with proteins implicated in RNA end processing and decay (Pat1, Lsm1, and Trf4) and regulation of polymerase II transcription (Rpn4, Spt3, Srb2, Soh1, Swr1, and Htz1)...
  33. ncbi Molecular cloning of an intracellular P-type ATPase from Dictyostelium that is up-regulated in calcium-adapted cells
    J Moniakis
    Department of Biology, York University, North York, Ontario, Canada
    J Biol Chem 270:28276-81. 1995
    ..The deduced protein product of this gene (PAT1) has a calculated molecular mass of 120,718 daltons...
  34. ncbi Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe
    J Davey
    School of Biochemistry, University of Birmingham, UK
    Curr Genet 26:105-12. 1994
    ..The second mutant contains the temperature-sensitive pat1-114 allele...
  35. ncbi Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast
    Y Watanabe
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Nature 386:187-90. 1997
    ..In the fission yeast Schizosaccharomyces pombe, inactivation of the protein kinase Pat1(Ran1) upon nutrient deprivation triggers entry into the meiotic cell cycle...
  36. ncbi Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1
    A B Rose
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853 1801, USA
    Plant J 11:455-64. 1997
    The expression of the Arabidopsis thaliana PAT1 gene, which encodes the tryptophan biosynthetic enzyme phosphoribosylanthranilate transferase, was investigated using translational fusions of the PAT1 promoter to the GUS reporter gene...
  37. pmc Characterization of functional regions in the Schizosaccharomyces pombe mei3 developmental activator
    W Wang
    Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, Health Science Center, State University of New York, Brooklyn, New York 11203, USA
    Genetics 150:1007-18. 1998
    ..Ectopic expression of mei3(+) in haploid cells causes meiotic catastrophe. Mei3 is an inhibitor of Ran1/Pat1 kinase and contains a nine-amino-acid motif, Mei3-RKDIII, that resembles two regions in the Ste11 substrate for ..
  38. ncbi Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation
    A Grallert
    Department of Genetics, University of Debrecen, Hungary
    Yeast 15:669-86. 1999
    ..The mutations in sep8, sep11 and sep16 suppressed the pat1-114-driven meiosis...
  39. ncbi Yeast Sm-like proteins function in mRNA decapping and decay
    S Tharun
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson 85721, USA
    Nature 404:515-8. 2000
    ..addition, the Lsm1-Lsm7 proteins co-immunoprecipitate with the mRNA decapping enzyme (Dcp1), a decapping activator (Pat1/Mrt1) and with mRNA...
  40. pmc The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation
    W He
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 158:1445-55. 2001
    ..In this study we present several observations to indicate that the LsmI/Pat1 complex has a second distinct function in protecting the 3'-UTR of mRNAs from trimming...
  41. ncbi Inositol is specifically involved in the sexual program of the fission yeast Schizosaccharomyces pombe
    Pia Manuela Voicu
    Department of Biochemistry, University of Medicine and Pharmacy Iasi, 6600 Iasi, Romania
    Arch Microbiol 177:251-8. 2002
    ..A diploid strain homozygous at the mating-type locus and carrying a pat1-114 temperature-sensitive mutation in homozygous configuration sporulated under inositol starvation at the ..
  42. ncbi Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells
    Snezana Petrovic
    Department of Medicine, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1207-16. 2002
    The apical Cl-/HCO exchanger called the putative anion transporter (PAT1; SLC26A6) is expressed on apical membranes of villus cells in the duodenum, but its location in the stomach remains unknown...
  43. pmc Requirements for intron-mediated enhancement of gene expression in Arabidopsis
    Alan B Rose
    Molecular and Cellular Biology, University of California, Davis, California, 95616, USA
    RNA 8:1444-53. 2002
    To explore possible mechanisms of intron-mediated enhancement of gene expression, the features of PAT1 intron 1 required to elevate mRNA accumulation were systematically tested in transgenic Arabidopsis...
  44. pmc A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast
    Cristina Mazzoni
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome, Italy
    Mol Biol Cell 14:721-9. 2003
    ..decapping, such as LSM1, DCP1, and DCP2, whereas a slight effect was observed in strains lacking the genes DHH1 and PAT1. This is the first time that a connection between mRNA stability and apoptosis is reported in yeast, pointing to ..
  45. ncbi The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
    Michael Boll
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, Hochfeldweg 2, 85350, Freising Weihenstephan, Germany
    Pflugers Arch 447:776-9. 2004
    ..in both intracellular and plasma membranes, was identified independently as a lysosomal amino acid transporter (LYAAT1) responsible for the export of lysosomal proteolysis products into the cytosol and as a proton/amino acid ..
  46. ncbi Truncated Sla1 induces haploid meiosis through the Pat1-Mei2 system in fission yeast
    Kaori Tanabe
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Shimane, Japan
    Biosci Biotechnol Biochem 68:266-70. 2004
    ..form of Sla1, induces ectopic meiosis in heterothallic fission yeast and this was possibly due to the inhibition of Pat1 kinase by Sla1DeltaC...
  47. ncbi Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2
    Martin Foltz
    Molecular Nutrition Unit, Center of Life and Food Sciences, Technical University of Munich, Germany
    Eur J Biochem 271:3340-7. 2004
    ..The PAT2 cDNA has been cloned from various human, mouse and rat tissues and belongs to a group of four genes (pat1 to pat4) with PAT3 and PAT4 still resembling orphan transporters...
  48. ncbi Meiosis induced by inactivation of Pat1 kinase proceeds with aberrant nuclear positioning of centromeres in the fission yeast Schizosaccharomyces pombe
    Yuji Chikashige
    Cell Biology Group, Kansai Advanced Research Center, National Institute of Information and Communications Technology, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe 651 2492, Japan
    Genes Cells 9:671-84. 2004
    ..pombe cells that were induced to meiosis by inactivation of Pat1 kinase (a key negative regulator of meiosis)...
  49. pmc Expression of the Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar Typhimurium mediates phagosomal escape
    Ted Whitworth
    Department of Pathology, University of Texas Medical Branch at Galveston, 77555 0609, USA
    Infect Immun 73:6668-73. 2005
    ..species have allowed for the identification of four genes with potential membranolytic activities (tlyA, tlyC, pat1, and pld)...
  50. doi CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion
    A K Singh
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Acta Physiol (Oxf) 193:357-65. 2008
    We investigated the role of the recently discovered, villous-expressed anion exchanger Slc26a6 (PAT1) and the predominantly crypt-expressed cystic fibrosis transmembrane regulator (CFTR) in basal and acid-stimulated murine duodenal HCO(3)(..
  51. pmc Genetic evidence for the importance of protein acetylation and protein deacetylation in the halophilic archaeon Haloferax volcanii
    Neta Altman-Price
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Israel
    J Bacteriol 191:1610-7. 2009
    ..volcanii led to the identification of three putative protein acetyltransferases belonging to the Gcn5 family, Pat1, Pat2, and Elp3, and two deacetylases, Sir2 and HdaI...
  52. doi 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination
    Mie Larsen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Eur J Pharm Sci 39:68-75. 2010
    ..In rats, 5-HTP decreased the initial absorption rate and increased AUC of gaboxadol. 5-HTP thus had a significant impact on the pharmacokinetic profile of gaboxadol...
  53. pmc A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism
    Bernardo Cuenca-Bono
    mRNA Transport Lab, Centro de Investigacion Principe Felipe, E 46013, Valencia, Spain
    BMC Cell Biol 11:19. 2010
    ..Through these associations, Sus1 mediates the nuclear dynamics of different gene loci and facilitate the export of the new transcripts...
  54. pmc HPat provides a link between deadenylation and decapping in metazoa
    Gabrielle Haas
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    J Cell Biol 189:289-302. 2010
    ..In this study, we report that Drosophila melanogaster HPat (homologue of Pat1), a conserved decapping activator, interacts with additional decapping factors (e.g...
  55. doi Effective isolation of retrotransposons and repetitive DNA families from the wheat genome
    Motonori Tomita
    Molecular Genetics Laboratory, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    J Integr Plant Biol 52:679-91. 2010
    ..turgidum genomic DNA. The D genome repetitive sequence pAt1 was isolated and used to identify an additional novel repetitive sequence family from wheat bacterial artificial ..
  56. pmc The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics
    S Frølund
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Br J Pharmacol 161:589-600. 2010
    BACKGROUND AND PURPOSE The intestinal proton-coupled amino acid transporter, SLC36A1, transports zwitterionic α-amino acids and drugs such as vigabatrin, gaboxadol and δ-aminolevulinic acid...
  57. doi Dietary fructose, salt absorption and hypertension in metabolic syndrome: towards a new paradigm
    M Soleimani
    Center on Genetics of Transport and Epithelial Biology, Department of Medicine, University of Cincinnati, OH 45267 0585, USA
    Acta Physiol (Oxf) 201:55-62. 2011
    ..intestine is predominantly mediated via the chloride/base exchangers DRA (Down Regulated in Adenoma) (SLC26A3) and PAT1 (Putative Anion Transporter 1) (SLC26A6), and the Na(+) /H(+) exchanger NHE3 (Sodium Hydrogen Exchanger3) (SLC9A3)...
  58. doi Transcriptional repression by glycerol of genes involved in the assimilation of n-alkanes and fatty acids in yeast Yarrowia lipolytica
    Katsuki Mori
    Department of Biotechnology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    FEMS Yeast Res 13:233-40. 2013
    ..Similarly, the expression of PAT1 encoding acetoacetyl-CoA thiolase involved in β-oxidation was induced by n-decane or oleic acid, but its ..
  59. pmc Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4
    Takahide Matsui
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba ku, Sendai, Miyagi 980 8578, Japan
    EMBO Rep 14:450-7. 2013
    ..Our findings reveal a new mechanism of regulation of mTORC1 signalling and autophagy, that is, quality control of PAT4 by Rab12...
  60. pmc Structural integrity of centromeric chromatin and faithful chromosome segregation requires Pat1
    Prashant K Mishra
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genetics 195:369-79. 2013
    ..Here we report that an evolutionarily conserved protein Pat1 is a structural component of Saccharomyces cerevisiae kinetochore and associates with centromeres in a NDC10-..
  61. pmc Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation
    Donghui Wu
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    Cell Res 24:233-46. 2014
    The evolutionarily conserved Lsm1-7-Pat1 complex is the most critical activator of mRNA decapping in eukaryotic cells and plays many roles in normal decay, AU-rich element-mediated decay, and miRNA silencing, yet how Pat1 interacts with ..
  62. pmc The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2
    Vidjaya Letchoumy Premkumar
    Department of Cancer Biology, University of Cincinnati, Cincinnati, Ohio, USA
    Eukaryot Cell 13:240-5. 2014
    ..that in Tetrahymena, the telomeric 3' overhang is protected by a three-protein complex composed of Pot1a, Tpt1, and Pat1. Here we show that Tpt1 and Pat1 associate with a fourth protein, Pat2 (Pot1 associated Tetrahymena 2)...
  63. pmc Synchronized fission yeast meiosis using an ATP analog-sensitive Pat1 protein kinase
    Lubos Cipak
    1 Max F Perutz Laboratories, University of Vienna, Vienna, Austria 2 Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia 3
    Nat Protoc 9:223-31. 2014
    ..Chemical inactivation of an ATP analog-sensitive form of the Pat1 kinase (pat1-as2) by adding the ATP analog 1-NM-PP1 in G1-arrested cells allows the induction of synchronous ..
  64. pmc The C-terminal domain from S. cerevisiae Pat1 displays two conserved regions involved in decapping factor recruitment
    Zaineb Fourati
    Laboratoire de Biochimie, Centre National de Recherche Scientifique CNRS UMR 7654, Ecole Polytechnique, Palaiseau Cedex, France Institut de Biochimie et Biophysique Moléculaire et Cellulaire IBBMC, Centre National de Recherche Scientifique CNRS UMR 8619, Bat 430, Universite Paris Sud, Orsay Cedex, France
    PLoS ONE 9:e96828. 2014
    ..Among these factors, Pat1 is considered to be a central scaffolding protein involved in Dcp2 activation but also in inhibition of translation ..
  65. doi Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors
    Raphael N Vuille-dit-Bille
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Amino Acids 47:693-705. 2015
    ..intestinal mRNA levels of ACE2, peptide transporter PEPT1 (SLC15A1) and AA transporters B(0)AT1 and PAT1 (SLC36A1)...
  66. pmc Pat1 protects centromere-specific histone H3 variant Cse4 from Psh1-mediated ubiquitination
    Prashant K Mishra
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Mol Biol Cell 26:2067-79. 2015
    ..The kinetochore protein Pat1 regulates the levels and spatial distribution of Cse4 at centromeres...
  67. pmc Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain
    Feng He
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    RNA 21:1633-47. 2015
    ..The positive elements recruit the specific decapping activators Edc3, Pat1, and Upf1 to form distinct decapping complexes and control the enzyme's substrate specificity and final activation...
  68. doi Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome
    Sarine Sebastian Karot
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India
    J Diabetes 8:629-39. 2016
    ..thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS).
  69. doi Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex
    Sevim Ozgur
    Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried Munich, Germany
    Cell Rep 13:703-11. 2015
    ..with the CCR4-NOT complex and functions in concert with several post-transcriptional regulators, including Edc3, Pat1, and 4E-T...
  70. pmc Mutagenic Analysis of the C-Terminal Extension of Lsm1
    Ashis Chowdhury
    Department of Biochemistry, Uniformed Services University of the Health Sciences USUHS, 4301, Jones Bridge Road, Bethesda, MD, 20814 4799, United States of America
    PLoS ONE 11:e0158876. 2016
    ..Lsm7 proteins are highly conserved in eukaryotes and they form a hetero-octameric complex together with the protein Pat1. The Lsm1-7-Pat1 complex plays a key role in mRNA decapping and 3'-end protection and therefore is required for ..
  71. pmc Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1
    Liufeng Zheng
    Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    Int J Mol Sci 17:. 2016
    ..The lysosomal AA sensors (PAT1 and SLC38A9) and cytoplasmic AA sensors (LRS, Sestrin2 and CASTOR1) also participate in regulating mTORC1 ..
  72. doi Bioinformatic analyses of GRAS genes in Betula kirghisorum based on transcriptome data
    C J Yang
    College of Forestry, Northeast Forestry University, Harbin, China
    Genet Mol Res 15:. 2016
    ..BkGRAS proteins were divided into six subfamilies: SCR, LISCL, SCL3, DELLA, HAM, and PAT1. These results provide important information for the further functional study of GRAS genes in B. kirghisorum.
  73. doi PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats
    Anne Jensen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark and
    Am J Physiol Endocrinol Metab 306:E65-74. 2014
    The proton-coupled amino acid transporter 1 (PAT1) is a transporter of amino acids in small intestinal enterocytes. PAT1 is, however, also capable of regulating cell growth and sensing the availability of amino acids in other cell types...
  74. ncbi A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport
    Martin Foltz
    Molecular Nutrition Unit, Institute of Nutritional Sciences, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    FASEB J 18:1758-60. 2004
    ..b>PAT1 and PAT2 members mediate electrogenic uptake of small, neutral amino acids and derivatives by cotransport of ..
  75. ncbi Sequence diversity of beta-tubulin (tubA) gene in Phaeosphaeria nodorum and P. avenaria
    Arkadiusz Malkus
    Department of Plant Pathology, Plant Breeding and Acclimatization Institute, Radzikow, Poland
    FEMS Microbiol Lett 249:49-56. 2005
    ..nodorum (PN-w and PN-b), P. avenaria f. sp. avenaria (Paa), homothallic P. avenaria f. sp. triticea (P.a.t.) (Pat1) and the P.a.t. isolate (Pat3) from the State of Washington...
  76. ncbi Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1
    Linda Metzner
    Membrane Transport Group, Biozentrum of the Martin Luther University Halle Wittenberg, Germany
    FASEB J 19:1468-73. 2005
    The proton-coupled amino acid transporter PAT1, cloned recently from brain and intestine, mediates the uphill transport of l- and d-proline, l-alanine, glycine, taurine, d-serine, GABA, and many other related compounds and drugs...
  77. ncbi Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles
    Seiji Miyauchi
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, USA
    Mol Membr Biol 22:549-59. 2005
    ..this investigation was to determine whether this pH-dependent uptake represents H(+)/amino acid cotransport via a PAT1-like transport system...
  78. doi Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells
    Katja Zebisch
    Biozentrum of the Martin Luther University Halle Wittenberg, Weinbergweg 22, 06120 Halle, Germany
    Amino Acids 44:373-81. 2013
    ..It is concluded that 3T3-L1 adipocytes express the H(+)-amino acid cotransport system PAT2...
  79. pmc Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae
    Jennifer S Chang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    G3 (Bethesda) 3:573-83. 2013
    ..In addition, mutations that impair the Lsm1-7-Pat1 complex, which regulates decapping of polyadenylated mRNAs, also partially suppress the spt10Δ growth defect...
  80. pmc Rickettsia typhi possesses phospholipase A2 enzymes that are involved in infection of host cells
    M Sayeedur Rahman
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Pathog 9:e1003399. 2013
    ..typhi. However, pat2 is not encoded in all Rickettsia genomes; yet another uncharacterized patatin (Pat1) is indeed ubiquitous...
  81. doi Isolation, purification, and characterization of phenylpyruvate transaminating enzymes of Erwinia carotovora
    A M Paloyan
    SPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, Yerevan, Republic of Armenia
    Biochemistry (Mosc) 77:98-104. 2012
    ..Two aromatic aminotransferases (PAT1 and PAT2) and an aspartic aminotransferase (PAT3) were found...
  82. doi Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers
    Carsten Uhd Nielsen
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken, Copenhagen, Denmark
    Eur J Pharm Biopharm 81:458-62. 2012
    ..Thus, there seems to be a partial substrate overlap between the basolateral GABA transporter and hPAT1, which may prove important for understanding drug interactions at the level of intestinal transport...
  83. ncbi Chemical inactivation of Pat1: A novel approach to synchronize meiosis
    Livia Perez-Hidalgo
    Instituto de Biología Molecular y Celular del Cáncer and Instituto de Biología Funcional y Genómica CSIC Universidad de Salamanca Instituto de Investigación Biomédica de Salamanca Salamanca, Spain
    Cell Cycle 11:1875. 2012
    ..Comment on: Guerra-Moreno A, et al. Cell Cycle 2012; 11:1621-5 and Cipak L, et al. Cell Cycle 2012; 11:1626-33...
  84. pmc An integrated field-effect microdevice for monitoring membrane transport in Xenopus laevis oocytes via lateral proton diffusion
    Daniel Felix Schaffhauser
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e39238. 2012
    ..Furthermore, the transport activity of the proton/amino acid cotransporter PAT1 assayed using conventional whole cell electrophysiology correlated well with changes in surface pH, confirming the ..
  85. doi Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides
    Sidsel Frølund
    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Mol Pharm 9:2761-9. 2012
    ..we have identified δ-aminolevulinic acid, Gly-Gly, and Gly-Sar as substrates of the amino acid transporter PAT1. The aim of the present study is to investigate if other Gly-containing dipeptides interact with PAT1, and whether ..
  86. doi Phylogenetic and population genetic analyses of Phaeosphaeria nodorum and its close relatives indicate cryptic species and an origin in the Fertile Crescent
    Megan C McDonald
    Plant Pathology Group, Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    Fungal Genet Biol 49:882-95. 2012
    ..Two species, P. nodorum and P. avenaria f. sp. tritici 1 (Pat1), comprised ~85% of the sampled isolates, making them the dominant wheat-infecting pathogens within the species ..
  87. pmc S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase
    Y Iino
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    EMBO J 10:221-6. 1991
    The Schizosaccharomyces pombe pac1 gene is a multicopy suppressor of the pat1 temperature-sensitive mutation, which directs uncontrolled meiosis at the restrictive temperature...
  88. ncbi Molecular cloning of the meiosis-induced rec10 gene of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Curr Genet 27:440-6. 1995
    ..During meiosis, thermally induced in a temperature-sensitive pat1-114 mutant, the transcript of rec10 was induced to a maximal level at 2-3 h but was present at much lower levels ..
  89. pmc A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast
    T Obara-Ishihara
    Okayama Cell Switching Project, ERATO, JRDC, Kyoto, Japan
    EMBO J 13:1863-72. 1994
    ..The Pat1 kinase plays a pivotal role in switching between vegetative growth and sexual development, and its inactivation in ..
  90. pmc Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genetics 136:769-79. 1994
    ..After pat1-114 temperature-induced meiosis, the transcripts of rec6 and rec12 were induced to maximal levels at 2-3 hr, at ..
  91. ncbi An intron-containing meiosis-induced recombination gene, rec15, of Schizosaccharomyces pombe
    Y Lin
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Microbiol 17:439-48. 1995
    ..During thermally induced meiosis in a pat1-114 (Ts) mutant, the rec15 transcripts were induced to maximal levels at 2-3h but were present at much lower levels ..
  92. ncbi Two novel genes involved in the sexual development of Schizosaccharomyces pombe
    M Molnar
    Department of Genetics, and Institute of Biology, University of Debrecen, Hungary
    Curr Genet 28:447-53. 1995
    ..ste15 is conjugation-specific and acts upstream of pat1 and ras1...
  93. ncbi Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase
    P Li
    Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, State University of New York Health Science Center at Brooklyn 11023, USA
    Cell 87:869-80. 1996
    ran1+ (pat1+) kinase inhibits exit from the mitotic cell cycle and entry into meiosis. Inactivation of ran1+ by mei3+ is sufficient to precipitate the entire meiotic developmental program...
  94. pmc Pat1: a topoisomerase II-associated protein required for faithful chromosome transmission in Saccharomyces cerevisiae
    X Wang
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nucleic Acids Res 24:4791-7. 1996
    ..cerevisiae, we have used a two-hybrid cloning approach. We report the isolation of the PAT1 gene (for protein associated with topoisomerase II), which encodes a novel 90 kDa proline- and glutamine-rich ..
  95. pmc Rapamycin specifically interferes with the developmental response of fission yeast to starvation
    R Weisman
    Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Israel
    J Bacteriol 179:6325-34. 1997
    ..Nor did rapamycin inhibit the unscheduled meiosis observed in pat1-114 mutants...
  96. ncbi Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum
    J Moniakis
    Department of Biology, York University, Toronto, Ontario, Canada, M3J 1P3
    J Cell Sci 112:405-14. 1999
    In Dictyostelium discoideum, the Ca2+-ATPase, PAT1, is localized to membranes of the contractile vacuole and its expression is upregulated substantially when the cells are grown in Ca2+-rich medium...
  97. pmc A Sm-like protein complex that participates in mRNA degradation
    E Bouveret
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO J 19:1661-71. 2000
    ..Deletions of LSM1, 6, 7 and PAT1 genes increased the half-life of reporter mRNAs...
  98. pmc Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast
    F Wyers
    Centre de Genetique Moleculaire, C N R S, 91198 Gif sur Yvette, France
    Mol Cell Biol 20:3538-49. 2000
    ..We found that deletion of the PAT1 (YCR077c) gene suppresses a PAB1 gene deletion and that Pat1p is required for the normal initiation of translation...
  99. pmc The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p
    C Bonnerot
    Centre de Recherche de Biochimie Macromoleculaire du CNRS, 34293 Montpellier, France
    Mol Cell Biol 20:5939-46. 2000
    ..Cloning of the wild-type gene for that suppressor reveals that it is identical to PAT1 (YCR077c), a gene whose product was reported to interact with Top2p...
  100. ncbi 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p
    Masamitsu Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Hongo, Japan
    Curr Biol 12:141-5. 2002
    The switch from mitosis to meiosis is controlled by the Pat1(Ran1) kinase-Mei2p system in Schizosaccharomyces pombe...
  101. ncbi Light-signalling pathways leading to the co-ordinated expression of HEMA1 and Lhcb during chloroplast development in Arabidopsis thaliana
    Alex C McCormac
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Plant J 32:549-59. 2002
    ..The hy1, hy2, hy5, fin219, fhy1, fhy3, spa1, ndpk2, and pat1 mutants also affect light regulation of both HEMA1 and Lhcb expression, but with differences in the relative ..

Research Grants17

  1. Paul K Herman; Fiscal Year: 2016
    ..Our data indicate that PKA directly phosphorylates Pat1, a conserved core constituent of P- bodies, and thereby disrupts the formation of the larger aggregate structures...
  2. Genetic Models for Disorders of Acid-Base Transport
    GARY EDWARD SHULL; Fiscal Year: 2013
    ..anhydrase activity and coupled to transport of other ions by Na/H exchangers (NHE1-4), Cl/HCO exchangers (AE1-4, PAT1, DRA), Na- HCO3 cotransporters (NBCe1, NBCe2), H,K-ATPases, and others...
  3. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    ..apical membrane transporters that absorb sodium and chloride include the chloride/base exchangers DRA (SLC26A3) and PAT1 (SLC26A6) and the Na+/H+ exchanger NHE3 in the intestine and PAT1 and NHE3 in the kidney proximal tubule...
  4. Mouse Models for Ion Homeostasis Defects in Heart
    Gary E Shull; Fiscal Year: 2010
    Our objective is to understand the mechanisms by which the NHE1 Na/H exchanger and the AE1, AE2, AE3, and PAT1 (Slc4a1-3 and Slc26a6) Cl/HCO3 exchangers affect cardiac Ca handling, contractility, and metabolism...
  5. FAYEZ KHALAF GHISHAN; Fiscal Year: 2015
    ..for optimal HCO3- transport as evidenced by the down- regulation of DRA (down-regulated in adenoma;SLC26A3) and PAT1 (putative anion transporter 1, SLC26A6) in NHE8-/- mice...
  6. MRNA DECAPPING IN YEAST
    ROY R PARKER; Fiscal Year: 2013
    ..the composition and ultrastructure of P-bodies II) Analyze P-body assembly III) Analyze the function of the Dhhl and Pat1 proteins IV) Determine if P-bodies function in other aspects of cytoplasmic mRNA physiology.
  7. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..SLC26A6, also known as PAT1 or CFEX, is a member of a large, highly conserved family of ion transporters (designated as SLC26A) many of which ..
  8. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..abstract_text> ..
  9. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  10. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation and gene structure of Na-coupled HCO3 transporters should enhance our knowledge on cell regulation and acid-base homeostasis. ..
  11. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    ..The potential for the clinical application of a novel treatment strategy to reduce urinary oxalate excretion is broad-based and highly significant...
  12. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  13. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..upon our studies using wild type (WT) and knockout (KO) mice, we have identified two key anion exchangers, namely PAT1 (slc26a6) and DRA (slc26a3), that contribute significantly to the movements of oxalate in the intestine and we ..
  14. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..One gene (SLC26A6), termed PAT1 is abundantly expressed in the apical membrane of small intestine and proximal tubule and is presumed to be ..
  15. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  16. Role of the Yeast Lsm Proteins in mRNA Decay
    THARUN SUNDARESAN; Fiscal Year: 2010
    ..abstract_text> ..
  17. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..