Genomes and Genes
Gene Symbol: SLC20A2
Description: solute carrier family 20 member 2
Alias: GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1, sodium-dependent phosphate transporter 2, gibbon ape leukemia virus receptor 2, murine leukemia virus, amphotropic, receptor for, murine leukemia virus, amphotropic; receptor, solute carrier family 20 (phosphate transporter), member 2
- Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2Pernille Bøttger
Department of Molecular Biology, Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark
Am J Physiol Cell Physiol 291:C1377-87. 2006..The mammalian PiT paralogs PiT1 and PiT2 are Na(+)-dependent P(i) (NaP(i)) transporters and are exploited by a group of retroviruses for cell entry...
- Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor functionPernille Bottger
Department of Molecular Biology and Institute of Experimental Clinical Research, Aarhus University, 8000 Aarhus C, Denmark
J Biol Chem 277:42741-7. 2002Type III sodium-dependent phosphate (NaP(i)) cotransporters, Pit1 and Pit2, have been assigned housekeeping P(i) transport functions and suggested involved in chondroblastic and osteoblastic mineralization and ectopic calcification...
- Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasisCheng Wang
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Nat Genet 44:254-6. 2012..Here, we identified mutations in SLC20A2, encoding the type III sodium-dependent phosphate transporter 2 (PiT2), in IBGC-affected families of varied ..
- Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of lifePernille Bøttger
Department of Molecular Biology, Aarhus University, C F Møllers Allé 3, Aarhus C, DK 8000, Denmark
BMC Biochem 12:21. 2011..Besides being Na(+)-dependent P(i) (NaP(i)) transporters, the mammalian PiT paralogs, PiT1 and PiT2, also are receptors for gamma-retroviruses...
- Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8J V Garcia
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
J Virol 65:6316-9. 1991..Here we report that by using human-Chinese hamster somatic cell hybrids and a retroviral vector, we have mapped the receptor for the amphotropic murine leukemia virus to the pericentromeric region of human chromosome 8...
- Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symportersM P Kavanaugh
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
Proc Natl Acad Sci U S A 91:7071-5. 1994..Accordingly, depletion of extracellular phosphate increased Ram-1 and Glvr-1 expression 3- to 5-fold. These results suggest simple methods to modulate retroviral receptor expression, with possible applications to human gene therapy...
- A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor familyM van Zeijl
Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY 10965
Proc Natl Acad Sci U S A 91:1168-72. 1994..Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy...
- The central half of Pit2 is not required for its function as a retroviral receptorPernille Bøttger
Department of Molecular Biology, Aarhus University, Aarhus C, Denmark
J Virol 78:9564-7. 2004The type III sodium-dependent phosphate (NaPi) cotransporter, Pit2, is a receptor for amphotropic murine leukemia virus (A-MuLV) and 10A1 MuLV...
- Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2Pernille Bøttger
Department of Molecular Biology, Aarhus University, Denmark
FEBS J 272:3060-74. 2005..phosphate (P(i)) transporter (PiT) family, the type III sodium-dependent phosphate (NaP(i)) transporters PiT1 and PiT2, have been assigned housekeeping P(i) transport functions and are suggested to be involved in chondroblastic and ..
- A family of retroviruses that utilize related phosphate transporters for cell entryD G Miller
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
J Virol 68:8270-6. 1994....
- PDGFB partial deletion: a new, rare mechanism causing brain calcification with leukoencephalopathyGael Nicolas
Inserm U1079, Rouen, France
J Mol Neurosci 53:171-5. 2014..Three IBGC-causing genes have been identified in the past 2 years: SLC20A2, PDGFRB, and PDGFB...
- Update and Mutational Analysis of SLC20A2: A Major Cause of Primary Familial Brain CalcificationRoberta R Lemos
Keizo Asami Laboratory LIKA, Universidade Federal de Pernambuco UFPE, Recife, Brazil
Hum Mutat 36:489-95. 2015..So far, variants in three genes have been linked to PFBC: SLC20A2, PDGFRB, and PDGFB...
- [Clinical features of familial idiopathic basal ganglia calcification caused by a novel mutation in the SLC20A2 gene]Min Zhu
Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P R China email
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32:64-8. 2015To describe clinical and genetic feature in a Chinese family with familial idiopathic basal ganglia calcification 3 (IBGC-3) caused by a novel mutation in the SLC20A2 gene.
- [The causative gene of Parkinsonism and its medical treatment strategy]Masatoshi Inden
Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University
Yakugaku Zasshi 134:1253-8. 2014..In 2012, solute carrier family 20A2 (SLC20A2) was identified as the causative gene for familial FD...
- First Japanese family with primary familial brain calcification due to a mutation in the PDGFB gene: an exome analysis studyTeruo Hayashi
Seiwakai Nishikawa Hospital, Hamada, Japan
Psychiatry Clin Neurosci 69:77-83. 2015..Mutations in a few genes have been identified as causing PFBC: namely, the SLC20A2 gene that codes for the sodium-dependent phosphate transporter and the PDGFRB gene that codes for the platelet-..
- Genetic diseases of renal phosphate handlingCarsten A Wagner
Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Nephrol Dial Transplant 29:iv45-54. 2014..proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1), NAPI-IIc (SLC34A3) and PIT-2 (SLC20A2)...
- Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnanciesHyun Yang
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Mol Reprod Dev 81:851-60. 2014..This relationship may contribute to a better understanding of the interrelationship between magnesium/inorganic phosphorus imbalances and preeclampsia development during preterm or term labor...
- Brain Calcification and Movement DisordersVladimir S Kostic
Clinic of Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia
Curr Neurol Neurosci Rep 17:2. 2017..Heterozygous mutations in four genes (SLC20A2, PDGFRB, PDGFB, XPR1) have recently proved to be the causes of the autosomal dominant forms of PFBC, also ..
- Evaluation of SLC20A2 mutations that cause idiopathic basal ganglia calcification in JapanMegumi Yamada
From the Laboratory of Medical Therapeutics and Molecular Therapeutics Y M, M Takagi, Y H, M K, I H, Gifu Pharmaceutical University, Gifu Department of Neurology M Tanaka, H I, J M, S Tsuji, The University of Tokyo Department of Neurology N A, G S, Nagoya University Department of Neuropsychiatry S K, Sapporo Medical University, Sapporo Department of Neurology Y Y, S Takashima, K T, Toyama University Hospital, Toyama Department of Neurology T T, Kagawa University Hospital, Kagawa Department of Neurology H H, S M, Tokyo Metropolitan Institute of Gerontology, Tokyo Department of Neurology and Geriatrics M Y, Y H, T I, and Division of Genomic Research, Life Science Research Center N S, Gifu University, Gifu, Japan
Neurology 82:705-12. 2014..To investigate the clinical, genetic, and neuroradiologic presentations of idiopathic basal ganglia calcification (IBGC) in a nationwide study in Japan...
- Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2Matthew H Crouthamel
From the Departments of Bioengineering M H C, E M L, N W C, M C W, D F P, X L, C M G, Nephrology W L L, and Cardiology Y L, M T C, University of Washington, Seattle and Department of Medicine, University of Colorado, Denver M L
Arterioscler Thromb Vasc Biol 33:2625-32. 2013..We investigated the in vivo requirement for PiT-1 in vascular calcification using a mouse model of chronic kidney disease and the potential compensatory role of PiT-2 using in vitro knockdown and overexpression strategies...
- Novel SLC20A2 mutations identified in southern Chinese patients with idiopathic basal ganglia calcificationWan Jin Chen
Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, China Electronic address
Gene 529:159-62. 2013..Recently, SLC20A2 was identified as a causative gene for familial IBGC, and three mutations were reported in a northern Chinese ..
- 1,25-Dihydroxyvitamin D(3) and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytesTimoklia Orfanidou
Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa 41110, Greece
Exp Biol Med (Maywood) 237:241-53. 2012..We propose that 1a,25(OH)(2)D(3) and Pi act synergistically through FGF23 signaling and ERK1/2 phosphorylation contributing to late hypertrophic events and impaired mineralization in osteoarthritic chondrocytes...
- Genetics and molecular biology of brain calcificationHao Deng
Department of Neurology, Third Xiangya Hospital, Central South University, Changsha, China Center for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha, China Electronic address
Ageing Res Rev 22:20-38. 2015..The aim of the review is to highlight clinical disorders associated with brain calcification and provide summary of current knowledge of diagnosis, genetics, and pathogenesis of brain calcification. ..
- XPR1 mutations are a rare cause of primary familial brain calcificationMathieu Anheim
Departement de Neurologie, Hopital de Hautepierre, CHU de Strasbourg, Strasbourg, France
J Neurol 263:1559-64. 2016..Using Sanger sequencing, we screened XPR1 in 18 unrelated patients with PFBC and no SLC20A2, PDGFB, or PDGFRB mutation...
- White matter involvement in a family with a novel PDGFB mutationRoberta Biancheri
Dubowitz Neuromuscular Service R B, UCL Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom Unit of Neuroradiology M S, Laboratorio di Neurogenetica e Neuroscienze A R, M I, F Z, G Gaslini Institute, Genova, Italy Neurology Unit M D S, E O Galliera Hospital, Genova, Italy Pediatric Neurology and Muscular Diseases Unit C M, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, G Gaslini Institute, Genova, Italy and Department of Advanced Biomedical Sciences M C, M D B D C, Federico II University, Naples, Italy
Neurol Genet 2:e77. 2016..1) Four causative genes have been identified: SLC20A2,(2) PDGFRB,(3) PDGFB,(4) and XPR1.(5).
- Identification of partial SLC20A2 deletions in primary brain calcification using whole-exome sequencingStephanie David
Inserm U1079, Rouen University, IRIB, Normandy University, Rouen, France
Eur J Hum Genet 24:1630-1634. 2016Primary brain calcification (PBC) is a dominantly inherited calcifying disorder of the brain. SLC20A2 loss-of-function variants account for the majority of families...
- Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1M P Keasey
Department of Biomedical Sciences Quillen College of Medicine, East Tennessee State University, Johnson City, USA
Sci Rep 6:25802. 2016..expression of two phosphate transporters which we have found to be associated with primary brain calcification (SLC20A2, whose promoter has a predicted vitamin D receptor binding site, and XPR1), and one unassociated (SLC20A1), in an ..
- The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission PathwaysKazuhiro Shima
Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University
Biol Pharm Bull 39:770-7. 2016..SLC20A1, SLC20A2, and SLC34A1 were detected within the mouse lumbar spinal cord...
- Primary brain calcification in patients undergoing treatment with the biphosphanate alendronateJ R M Oliveira
Neuropsychiatric Department Federal University of Pernambuco UFPE, Recife, Pernambuco Brazil
Sci Rep 6:22961. 2016..Recent studies found mutations in four genes (SLC20A2, PDGFRB, PDGFB and XPR1)...
- Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cellsMary C Wallingford
University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA Electronic address
Reprod Biol 16:13-26. 2016..parameters for placental phosphate transport match those of the type III phosphate transporters, Slc20a1 and Slc20a2. Both members are expressed in human placenta, and their altered expression is linked to preeclampsia...
- Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluidNina Jensen
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Neurogenetics 17:125-30. 2016Mutations in the SLC20A2-gene encoding the inorganic phosphate (Pi) transporter PiT2 can explain approximately 40% of the familial cases of the rare neurodegenerative disorder primary familial brain calcification (Fahr's disease)...
- A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assemblyN B Stafuzza
Departamento de Biologia, Instituto de Biociencias, Letras e Ciencias Exatas, Universidade Estadual Paulista Julio de Mesquita Filho, Sao Jose do Rio Preto, SP, Brasil
Genet Mol Res 14:13096-104. 2015..RH) map from BBU1 using BBURH5000 panel adding nine new genes (ADRB3, ATP2C1, COPB2, CRYGS, P2RY1, SLC5A3, SLC20A2, SST, and ZDHHC2) and one microsatellite (CSSM043) to the set of markers previously mapped on BBU1...
- Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2Roar Fjaer
Department of Medical Genetics, Oslo University Hospital and University of Oslo, Kirkeveien 166, Bygg 25, Avdeling for medisinsk genetikk, Postboks 4956 Nydalen 0424 Oslo, Norway Electronic address
Eur J Med Genet 58:624-8. 2015..brain calcification (PFBC) has increased considerably in recent years due to the finding of causal genes like SLC20A2, PDGFRB and PDGFB. The phenotype of PFBC is complex and has as of yet been poorly delineated...
- Mutation screening of PDGFB gene in Chinese population with primary familial brain calcificationXiang Ping Yao
Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China
Gene . 2016Until recently, primary familial brain calcification (PFBC) has been determined by four genes, SLC20A2, PDGFRB, PDGFB and XPR1. No studies have been carried out to analyze the gene mutation of PDGFB in Chinese population.
- Brain calcification process and phenotypes according to age and sex: Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriersGael Nicolas
Department of Genetics, Rouen University Hospital, Rouen, France
Am J Med Genet B Neuropsychiatr Genet 168:586-94. 2015..Three causative genes have been identified: SLC20A2, PDGFRB and, recently, PDGFB, whose associated phenotype has not yet been extensively studied...
- A new SLC20A2 mutation identified in southern Italy family with primary familial brain calcificationMonica Gagliardi
Institute of Molecular Bioimaging and Physiology, National Research Council, Section of Germaneto, Catanzaro, Italy Electronic address
Gene 568:109-11. 2015..PFBC is genetically heterogeneous and typically transmitted in an autosomal dominant fashion. Three causative genes have been reported: SLC20A2, PDGFRB and PDGFB.
- High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1Diala El Husseini
Laboratoire d Études Moléculaires des Valvulopathies LEMV, Groupe de Recherche en Valvulopathies GRV, Quebec Heart and Lung Institute Research Center, Department of Surgery, Laval University, Quebec, Canada
PLoS ONE 8:e53393. 2013..Gene profiling of Pi transporters revealed that VIC culture expresses SLC201A1/Pit1 and SLC20A2/Pit2...
- Inflammatory Effects of Nitrogen-Containing Bisphosphonates (N-BPs): Modulation by Non-N-BPsKazuhiro Shima
Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University
Biol Pharm Bull 40:25-33. 2017..The mRNAs of SLC20a1, SLC20a2, and SLC34a2 (but not of SLC34a1 and SLC34a3) were detected in the soft-tissues of hind-paw-pads...
- Genetics in arterial calcification: lessons learned from rare diseasesYvonne Nitschke
Department of General Pediatrics, Münster University Children s Hospital, D 48149 Munster, Germany
Trends Cardiovasc Med 22:145-9. 2012..of GACI, PXE, CALJA, and IBGC, it can be speculated that the underlying disease genes-ENPP1, ABCC6, NT5E, and SLC20A2, respectively-drive a cohesive molecular pathophysiology system modulated by ATP metabolism, inorganic ..
- Expression levels of the PiT-2 receptor explain, in part, the gestational age-dependent alterations in transduction efficiency after in utero retroviral-mediated gene transferFerhat Ozturk
Department of Animal Biotechnology, University of Nevada, Reno, NV, USA
J Gene Med 14:169-81. 2012....
- Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcificationSandy Chan Hsu
Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Neurogenetics 14:11-22. 2013..We performed a mutational analysis of SLC20A2, the first gene found to cause IBGC, to assess its genetic contribution to familial IBGC...
- Phosphate transporters of the SLC20 and SLC34 familiesIan C Forster
Institute of Physiology and Zurich Center for Integrated Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Mol Aspects Med 34:386-95. 2013..The SLC20 proteins, PiT-1 (SLC20A1), PiT-2 (SLC20A2) are expressed ubiquitously in all tissues and although generally considered as "housekeeping" transport proteins,..
- Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransportersMaria Haller
Department of Nephrology, Medical University of Vienna, Vienna, Austria
PLoS ONE 7:e39229. 2012..We hypothesize that another mechanism such as a basolateral phosphate transporter may be responsible for the sirolimus induced phosphaturia...
- The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levelsSoline Bourgeois
Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Pflugers Arch 465:1557-72. 2013..The sensitivity to FGF23 may be regulated by adapting FRS2α abundance and phosphorylation. ..
- An externally accessible linker region in the sodium-coupled phosphate transporter PiT-1 (SLC20A1) is important for transport functionSilvia Ravera
Institute of Physiology and Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
Cell Physiol Biochem 32:187-99. 2013..The aims of this study were to investigate the topology of a linker region in PiT-1 between the predicted 2(nd) and 3(rd) transmembrane domains and to investigate the functional consequences of cysteine substitutions in this region...
- Localization of type-III sodium-dependent phosphate transporter 2 in the mouse brainMasatoshi Inden
Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University, Gifu, Japan
Brain Res 1531:75-83. 2013..phosphate transporters 1 and 2 (PiT-1 and PiT-2, respectively) are proteins encoded by SLC20A1 and SLC20A2, respectively...
- Targeting of c-Met and urokinase expressing human glioma cell lines by retrovirus vector displaying single-chain variable fragment antibodySounkary K Solly
EMI 00 20, INSERM, Universite Paris XI, Bat Grégory Pincus, Le Kremlin Bicetre Cedex, France
Cancer Biol Ther 4:987-92. 2005..Our study has significant implications for the design of targeting strategies for gliomas expressing high levels of c-Met...
- Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptorC Salaun
Laboratoire Rétrovirus et Transfert Génétique, CNRS URA 1930, Institut Pasteur, 75724 Paris, France
J Virol 75:5584-92. 2001....
- Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcificationGael Nicolas
1 Inserm U1079, Rouen, France
Brain 136:3395-407. 2013..The first causal genes, SLC20A2 and PDGFRB, have recently been reported...
- Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virusS Kubo
Department of Genetics, Hyogo College of Medicine, Nishinomiya, Japan
Cancer Gene Ther 20:671-7. 2013..These data indicate the potential utility of GALV-RRV-mediated prodrug activator gene therapy in the treatment of mesothelioma. ..
- Phosphate transporters and their functionJurg Biber
Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Annu Rev Physiol 75:535-50. 2013..In contrast, in the human kidney, NaPi-IIc appears to have a relatively greater role. The physiological relevance of PiT-2 to P(i) reabsorption remains to be elucidated...
- An update on primary familial brain calcificationRoberta R Lemos
Universidad de Santiago de Compostela, Santiago de Compostela, Spain Fundación Pública Galega de Medicina Xenómica SERGAS IDIS Hospital Clínico Universitario, Santiago de Compostela, Spain
Int Rev Neurobiol 110:349-71. 2013..Recently, mutations in the SLC20A2 gene coding for the inorganic phosphate transporter PiT2 were linked to PFBC, thereby implicating impaired ..
- Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulatedDawei Zhao
Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Eur J Oral Sci 114:517-23. 2006..We therefore examined the temporospatial expression patterns of Pit2 during murine odontogenesis...
- Retroviral display of urokinase-binding domain fused to amphotropic envelope proteinAntoine Boucquey
EMI 00 20, INSERM and Université Paris XI, Bat Grégory Pincus, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
Biochem Biophys Res Commun 331:1485-93. 2005..This stimulatory effect of uPA on infection of huPAR-MDCK cells by the ATF-env virus was completely abolished by methyl-beta-cyclodextrin, suggesting that this effect involves the caveolar endocytosis pathway...
- Preferential retroviral-mediated transduction of EBV- and CMV-specific T cells after polyclonal T-cell activationD Sauce
INSERM U645 UPRES EA 2284, IFR 133 IBCT, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
Gene Ther 11:1019-22. 2004..Moreover, EBV-T and CMV-T cells proliferate more extensively as compared to bulk CD8+ T cells. Thus, retroviral-mediated transduction can be biased toward a given antigenic specificity, even under conditions of polyclonal stimulation...
- The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptorsJames F Collins
Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona College of Medicine, 1501 N Campbell Ave, P O Box 245073, Tucson, AZ 85724, USA
Pflugers Arch 447:647-52. 2004....
- Observation of chondrocyte aggregate formation and internal structure on micropatterned fibroin-coated surfaceNaoyoshi D Kachi
Graduate School of Engineering, Kyoto University, Kyoto, Japan
Biomed Mater Eng 20:55-63. 2010..These results suggest two functional structures in the aggregates, which may explain the good balance between the maintenance of their differentiated phenotype and proliferation rate in the fibroin sponge...
- Bone marrow stromal cells as targets for gene therapy of hemophilia AM K Chuah
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology University of Leuven, Belgium
Hum Gene Ther 9:353-65. 1998..These findings demonstrate the potential of BM stromal cells for gene therapy in general and hemophilia A in particular...
- Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liverPascal Frei
Division of Clinical Pharmacology and Toxicology, Dept of Medicine, Univ Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Am J Physiol Gastrointest Liver Physiol 288:G771-8. 2005..We conclude that NaPi-IIb is most probably involved in the reabsorption of P(i) from primary hepatic bile and thus might play an important role in the regulation of biliary P(i) concentration...
- Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cellsKeinoshin Wada
Division of Oral and Maxillofacial Surgery, Department of Organ Therapeutics, Graduate School of Medicine, Kobe University, Kobe, Japan
J Cell Physiol 198:40-7. 2004....
- Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentrationChristine Salaun
Unité Rétrovirus et Transfert Génétique, CNRS URA 1930, Institut Pasteur, 75724 Paris, France
J Virol 76:4304-11. 2002b>Pit2 is a type III sodium-dependent phosphate transporter and the cell surface receptor for amphotropic murine leukemia virus...
- Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoterL Bai
Department of Pediatrics and Physiology, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
Biochim Biophys Acta 1522:42-5. 2001....
- Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperationS Valsesia-Wittmann
Vectorologie Rétrovirale et Thérapie Génique, Ecole Normale Superieure de Lyon, INSERM U412, 69364 Lyon Cedex 07, France
J Virol 75:8478-86. 2001..This interaction leads to natural fusion triggering and entry of viruses into targeted cells...
- Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1J Stitz
Department of Medical Biotechnology, Paul Ehrlich Institut, Langen, 63225, Germany
Virology 273:16-20. 2000..Thus, HIV-1(GaLV) and HIV-1(10A1) pseudotype vectors may be useful for efficient gene transfer into a variety of human tissues like primary human hematopoietic cells...
- Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3K Katai
Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City, Tokushima 770, Japan
Biochem J 343:705-12. 1999..PiUS and PiT-2 might be important components in the regulation of the intestinal P(i) transport system by P(i) restriction and 1,25-(OH)(2)D(3)...
- In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone developmentG Palmer
WHO Collaborating Center for Osteoporosis and Bone Diseases, Department of Internal Medicine, University of Geneva, Switzerland
Bone 24:1-7. 1999..This observation represents the first in vivo evidence consistent with a potential role for this phosphate transporter in matrix calcification...
- Lack of functional Pit-1 and Pit-2 expression on hematopoietic stem cell linesS Thomsen
Heinrich Pette Institut für Experimentelle Virologie und Immunologie, Universitat Hamburg, Deutschland
Acta Haematol 99:148-55. 1998..Either the receptor protein is incorrectly processed in these cells or a cofactor is missing in FDC-Pmix cells that is necessary for efficient binding and/or penetration...
- Role of the progressive ankylosis gene (ank) in cartilage mineralizationWei Wang
Department of Orthopaedics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Mol Cell Biol 25:312-23. 2005....
- Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell linesD E Sabatino
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4442, USA
Blood Cells Mol Dis 23:422-33. 1997..We conclude that the improved transduction was a direct effect of the increased levels of receptor mRNA and unrelated to changes in the cell cycle status...
- Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelopeJ S Lam
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hum Gene Ther 7:1415-22. 1996....
- Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor familyM P Kavanaugh
Vollum Institute, Oregon Health Sciences University, Portland, USA
Kidney Int 49:959-63. 1996..The distinct structural and functional properties of these molecules establishes them as members of a new family of phosphate transporters which may play a major role in phosphate uptake in a wide variety of cell types...
- Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirusL Pedersen
Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965
J Virol 69:2401-5. 1995..for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related gene Glvr2 encodes the human receptor for amphotropic murine leukemia viruses (A-MLVs)...
- The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible speciesS L Kozak
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
J Virol 69:3433-40. 1995..We conclude that amphotropic gp70 binds more strongly to rRam-1 than to the homologous hamster protein and that this stable attachment is necessary for infection, interference, membrane fusion, and pathogenesis...
- A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 geneM Delhase
Pharmacology Department, Medical School, Free University of Brussels V U B, Belgium
Gene 155:273-5. 1995..The use of this splice site is responsible for a 78-bp in-frame insertion upstream from exon 2 and leads to the hGHF-2/PIT-2 cDNA detected in normal human pituitary...
- Complete amino acid sequence of p453-plasmid-mediated PIT-2 beta-lactamase (SHV-1)M Barthelemy
Museum national d histoire naturelle, C N R S U A 401, Paris, France
Biochem J 251:73-9. 1988..Thus PIT-2 enzyme could represent an evolutionary step between a chromosomally encoded beta-lactamase and the plasmid-mediated TEM beta-lactamases...
- Evaluation of simple periodontal screening technique currently used in the UK armed forcesK A Eaton
RAF Halton, Aylesbury, Buckinghamshire, UK
Community Dent Oral Epidemiol 17:190-5. 1989..as periodontally healthy (PIT 0), with gingivitis but no pocketing exceeding 4 mm (PIT 1), with pocketing 4-5 mm (PIT 2), or with 6 mm + pocketing (PIT 3)...
- The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary PiRicardo Villa-Bellosta
Institute of Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 296:F691-9. 2009....
- The regulation of renal phosphate transportJudith Blaine
Department of Medicine, University of Colorado, Denver, 80045, USA
Adv Chronic Kidney Dis 18:77-84. 2011....
- Phosphate transport in the kidneyHeini Murer
Institute of Physiology and Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
J Nephrol 23:S145-51. 2010..several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families...
- Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransportersIchiro Kaneko
Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho 3, Tokushima, Japan
Pflugers Arch 461:77-90. 2011....
- Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransportersNicolas Picard
Institute of Anatomy, University of Zurich, Zurich, Switzerland
Pflugers Arch 460:677-87. 2010..proximal tubule is mediated by at least three transporters, NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3), and Pit-2 (SLC20A2)...
- Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesisPaulina Oca
Center for Translational Medicine, Department Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Physiol 224:540-8. 2010..Our findings indicate that TGFbeta stimulation of ANK expression is dependent upon the influx of phosphate and calcium into ATDC5 cells at all stages of differentiation...
- Phosphaturic action of fibroblast growth factor 23 in Npt2 null miceYuka Tomoe
Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
Am J Physiol Renal Physiol 298:F1341-50. 2010..induced severe hypophosphatemia and markedly decreased the levels of Npt2c, type III Na-dependent P(i) transporter (PiT2) protein, and renal Na/P(i) transport activity...
- Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosisRicardo Villa-Bellosta
Laboratory of Molecular Toxicology, Veterinary Faculty, University of Zaragoza, Calle Miguel Servet 177, 50013 Zaragoza, Spain
Pflugers Arch 459:499-508. 2010..5 and 60% of Pi transport at pH 6.0, depending on the pH and the physiological conditions...
- Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiencySophia Y Breusegem
Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA
Am J Physiol Renal Physiol 297:F350-61. 2009....
- Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate depositionRicardo Villa-Bellosta
Laboratory of Molecular Toxicology, University of Zaragoza, Spain
Arterioscler Thromb Vasc Biol 29:761-6. 2009..However, aortic vascular smooth muscle cells (VSMCs) only express PFA-resistant, type III transporters (Pit-1 and Pit-2). Therefore, in this article we have studied the mechanism of VC prevention by PFA...
- Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonistsBenchun Miao
Department of Biochemistry, Tufts University School of Medicine, Boston, MA, USA
Autophagy 7:650-1. 2011....
- Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenateRicardo Villa-Bellosta
Laboratory of Molecular Toxicology, University of Zaragoza, E50013 Zaragoza, Spain
Toxicol Appl Pharmacol 232:125-34. 2008..Our data agree with current toxicokinetic knowledge, and they explain the asymmetric excretion of trivalent and pentavalent arsenic species into bile and urine...
- Pavlovian influences on goal-directed behavior in mice: the role of cue-reinforcer relationsHans S Crombag
Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Mem 15:299-303. 2008..Whereas 10-sec training conditions produced strong CRf (and no PIT), 2-min training conditions produced robust PIT (but no CRf)...
- Characterisation of inorganic phosphate transport in bovine articular chondrocytesDaniel H Solomon
Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
Cell Physiol Biochem 20:99-108. 2007..RT-PCR analysis confirmed that two members of the NaPi III family, Pit-1 and Pit-2, are expressed, but that NaPi II transporters are not...
- Phosphate transporters: a tale of two solute carrier familiesLeila V Virkki
Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Am J Physiol Renal Physiol 293:F643-54. 2007..In this review, we focus on recent advances in the characterization of the transport kinetics, structure-function relationships, and physiological implications of having two distinct Na+/P(i) cotransporter families...
- Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurementsSilvia Ravera
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
Am J Physiol Cell Physiol 293:C606-20. 2007..Significantly, in contrast to type II Na(+)-P(i) cotransporters, the transport inhibitor phosphonoformic acid did not inhibit PiT-1 or PiT-2 activity...
- Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transportCecilia C Low Wang
Research Service, Denver Veterans Affairs Medical Center, Denver, CO 80220, United States
Atherosclerosis 195:e65-75. 2007..This effect of insulin contrasts with its effect to induce phosphate transport in VSMC...
- Poor sanitation and helminth infection protect against skin sensitization in Vietnamese children: A cross-sectional studyCarsten Flohr
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
J Allergy Clin Immunol 118:1305-11. 2006..Geohelminth infection and poor hygiene may be protective against allergic sensitization...
- Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cellsAtsushi Suzuki
Division of Endocrinology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
J Bone Miner Res 21:674-83. 2006..The role of Pi transport in BMP-2-induced matrix calcification was studied. BMP-2 enhances Pit-1 Pi transporters in osteogenic cells. Experimental analysis suggest that this response is required for bone matrix calcification...
- Tomas Kirchhausen; Fiscal Year: 2016....
- Regulation of Renal Phosphate Transport by LipidsMoshe Levi; Fiscal Year: 2013....
- Cecilia M Giachelli; Fiscal Year: 2016..Our studies aim to determine mechanisms of vascular calcification such that new targets for therapeutic treatment can be identified. ..