SLC1A1

Summary

Gene Symbol: SLC1A1
Description: solute carrier family 1 member 1
Alias: DCBXA, EAAC1, EAAT3, SCZD18, excitatory amino acid transporter 3, excitatory amino acid carrier 1, neuronal and epithelial glutamate transporter, sodium-dependent glutamate/aspartate transporter 3, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Species: human

Top Publications

  1. ncbi Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Neurosci 14:5559-69. 1994
  2. ncbi Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
    C I Lin
    Johns Hopkins University, Department of Neurology and Neuroscience, Baltimore, Maryland 21287, USA
    Nature 410:84-8. 2001
  3. ncbi Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
    Paul Daniel Arnold
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 63:769-76. 2006
  4. ncbi Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder
    Diane E Dickel
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Arch Gen Psychiatry 63:778-85. 2006
  5. ncbi Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007
  6. pmc Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1
    Zhou Zhang
    University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:18025-30. 2007
  7. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
  8. doi Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms
    Jun Soo Kwon
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
    Arch Gen Psychiatry 66:1233-41. 2009
  9. pmc Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry, Stony Brook University, New York, NY, USA
    J Autism Dev Disord 40:1139-45. 2010
  10. pmc Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 156:472-7. 2011

Research Grants

  1. CHARLES KENNETH MESHUL; Fiscal Year: 2016
  2. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2012
  3. Stephen W Scherer; Fiscal Year: 2016
  4. Marian DiFiglia; Fiscal Year: 2014
  5. High-Level Expression of Human EAAT3 for Biochemical and Structural Analysis
    DIANNE LYNN DECAMP; Fiscal Year: 2011
  6. Molecular Basis of Glutamate Transport
    CHRISTOF THEODOR GREWER; Fiscal Year: 2012
  7. JoEllen Welsh; Fiscal Year: 2014
  8. Translating OCD gene-association studies into mice to examine SLC1A1 function
    Jeremy Veenstra-Vanderweele; Fiscal Year: 2013
  9. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    Michael Robinson; Fiscal Year: 2006
  10. Disruption of an epigenetic locus controlling EAAC1 expression in schizophrenia
    Marina Myles-Worsley; Fiscal Year: 2013

Detail Information

Publications238 found, 100 shown here

  1. ncbi Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Neurosci 14:5559-69. 1994
    ..Three glutamate transporters expressed in human motor cortex, termed EAAT1, EAAT2, and EAAT3 (for excitatory amino acid transporter), have been characterized by their molecular cloning and functional ..
  2. ncbi Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
    C I Lin
    Johns Hopkins University, Department of Neurology and Neuroscience, Baltimore, Maryland 21287, USA
    Nature 410:84-8. 2001
    Excitatory amino-acid carrier 1 (EAAC1) is a high-affinity Na+-dependent L-glutamate/D,L-aspartate cell-membrane transport protein. It is expressed in brain as well as several non-nervous tissues...
  3. ncbi Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
    Paul Daniel Arnold
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 63:769-76. 2006
    ..This region contains the gene encoding the neuronal glutamate transporter, SLC1A1. SLC1A1 represents an excellent candidate gene for OCD based on evidence from neuroimaging and animal studies that ..
  4. ncbi Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder
    Diane E Dickel
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Arch Gen Psychiatry 63:778-85. 2006
    ..The glutamate transporter gene solute carrier family 1, member 1 (SLC1A1) is a promising functional candidate in this region because altered glutamatergic concentrations have been found ..
  5. ncbi Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007
    ..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required.
  6. pmc Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1
    Zhou Zhang
    University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:18025-30. 2007
    Glutamate transport by the excitatory amino acid carrier EAAC1 is known to be reversible...
  7. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
    Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD).
  8. doi Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms
    Jun Soo Kwon
    Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
    Arch Gen Psychiatry 66:1233-41. 2009
    ..The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate ..
  9. pmc Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry, Stony Brook University, New York, NY, USA
    J Autism Dev Disord 40:1139-45. 2010
    Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum ..
  10. pmc Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 156:472-7. 2011
    b>SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessive-compulsive disorder (OCD)...
  11. doi Interaction between genetic variants of DLGAP3 and SLC1A1 affecting the risk of atypical antipsychotics-induced obsessive-compulsive symptoms
    Seunghyong Ryu
    Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Am J Med Genet B Neuropsychiatr Genet 156:949-59. 2011
    ..the interactions between DLGAP3 and a previously reported susceptibility gene, the glutamate transporter gene SLC1A1, regarding this phenotype...
  12. doi Association of SNPs linked to increased expression of SLC1A1 with schizophrenia
    Yasue Horiuchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:30-7. 2012
    ..The SLC1A1 gene located at 9p24 encodes the glutamate transporter EAAT3/EAAC1...
  13. doi Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family
    Marina Myles-Worsley
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 162:87-95. 2013
    ..We investigated a deletion at the SLC1A1 glutamate transporter gene originally identified as a copy number variant exclusively carried by members of a 5-..
  14. ncbi Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia
    Xiangdong Deng
    Division of Disease Genes, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:271-8. 2007
    ..We report here association studies of schizophrenia with three glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 encoding the glutamate transporters EAAT3, EAAT1, and EAAT4, respectively...
  15. doi A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families
    Y Y Shugart
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
    Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009
    SLC1A encodes the neuronal and epithelial glutamate transporter and was previously tested as a candidate for obsessive-compulsive disorder (OCD) by several research groups...
  16. pmc Family-Based Association Testing of OCD-associated SNPs of SLC1A1 in an autism sample
    Camille W Brune
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois Chicago, Chicago, Illinois 60608, USA
    Autism Res 1:108-13. 2008
    Reports identified the neuronal glutamate transporter gene, SLC1A1 (OMIM 133550, chromosome 9p24), as a positional and functional candidate gene for obsessive-compulsive disorder (OCD)...
  17. doi Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample
    Katri Kantojärvi
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Psychiatr Genet 20:102-8. 2010
    ..Considering the common metabolic pathway and recent results from association studies both in OCD and ASDs, a question, whether there is common molecular background in ASDs and OCD, was raised...
  18. doi Polymorphisms in the glutamate transporter gene SLC1A1 and obsessive-compulsive symptoms induced by second-generation antipsychotic agents
    Frederike Schirmbeck
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Psychiatr Genet 22:245-52. 2012
    ..risk factor for these secondary OCS was recently described in the gene SLC1A1 encoding the neuronal glutamate transporter excitatory amino acid carrier 1. The aim of this study was to replicate these findings in a European sample.
  19. ncbi A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus
    K Kosakai
    Department of Biology, Tokyo Gakugei University, Japan
    J Comp Physiol B 171:303-12. 2001
    ..the cricket is similar to the high affinity glutamate transporters cloned from human brain, especially EAAT1 and EAAT3. Unlike mammalian transporters, however, serine-O-sulfate has the most potent action, suggesting the unique ..
  20. ncbi The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
    J de Vente
    European Graduate School of Neuroscience EURON, Maastricht University, Department of Psychiatry and Neuropsychology, UNS50, POB 616, 6200 MD Maastricht, The Netherlands
    J Chem Neuroanat 31:275-303. 2006
    ..molecules for acetylcholine, GABA, and glutamate (type 1 and type 2), parvalbumin, glutamate transporter molecule EAAT3, synaptophysin, substance P, calcitonin gene-related peptide, and isolectin B4...
  21. ncbi Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats
    Yueh Hua Tai
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    Pain 129:343-54. 2007
    ..infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (GTs), GLAST, GLT-1, and EAAC1, expression in the rat spinal cord dorsal horn...
  22. ncbi Preventive effects of intrathecal methylprednisolone administration on spinal cord ischemia in rats: the role of excitatory amino acid metabolizing systems
    G J Wu
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Neuroscience 147:294-303. 2007
    ..e. the Glu-Asp transporter (GLAST), Glu transporter-1 (GLT-1), and excitatory amino acid carrier one (EAAC1); glutamine synthetase (GS); and glutamate dehydrogenase (GDH)) in spinal cord ischemia...
  23. pmc Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse
    Zhiqiang Chen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston MA 02114, USA
    J Neurophysiol 103:2581-6. 2010
    ..all three transporters [glutamate/aspartate transporter (GLAST), glutamate transporter-1 (GLT1), and excitatory amino acid carrier 1 (EAAC1)]. l-serine-O-sulfate (SOS) blocks both GLAST and EAAC1 without effect on GLT1...
  24. ncbi PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton
    Massimiliano G Bianchi
    Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Italy
    Neurochem Int 48:341-9. 2006
    The activity and the membrane expression of EAAT3 glutamate transporter are stimulated upon PKC activation by phorbol esters in C6 rat glioma cells...
  25. doi Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats
    Y H Tai
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Neuroscience 153:823-31. 2008
    ..transporter (GLAST) and glutamate transporter-1 (GLT-1) and restores neuronal glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression in chronically morphine-infused rats...
  26. ncbi Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid
    C Grewer
    Max Planck Institut fur Biophysik, Kennedyallee 70, D 60596 Frankfurt, Germany
    Biochemistry 40:232-40. 2001
    ..D-aspartate), and its application for studying the molecular mechanism of the neuronal excitatory amino acid carrier 1 (EAAC1)...
  27. ncbi Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions
    Lidia Struzynska
    Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    J Inorg Biochem 98:951-8. 2004
    ..However, the K(+)-evoked release of Glu increases by 20% over control values and the quantity of neuronal EAAC1 transporter for glutamate reaches remarkably higher levels after Pb treatment...
  28. pmc Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1
    Zhen Tao
    University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 129:331-44. 2007
    The neuronal glutamate transporter EAAC1 contains several conserved acidic amino acids in its transmembrane domain, which are possibly important in catalyzing transport and/or binding of co/countertransported cations...
  29. doi Changes in messenger RNA abundance of amino acid transporters in rat mammary gland during pregnancy, lactation, and weaning
    Gabriela Aleman
    Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, DF 14000, Mexico
    Metabolism 58:594-601. 2009
    ..was to establish the pattern of changes in messenger RNA abundance of the amino acid transporters ASC, system L, EAAC1, GLAST, CAT-1, and Tau in the mammary gland of the rat during different stages of pregnancy and lactation...
  30. doi Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters
    Jui An Lin
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Brain Res 1232:61-9. 2008
    ..higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment. Acute injection of PTX-treated rats with either AMI (15 microg, i.t...
  31. doi Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: role of glutamate transporters
    W F Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Neuroscience 165:1217-32. 2010
    ..transporters (GTs), glial transporter Glu-Asp transporter (GLAST), Glu transporter-1 (GLT-1), and excitatory amino acid carrier 1 (EAAC1) protein 48 h after spinal cord ischemic surgery...
  32. ncbi Properties of excitatory amino acid transport in the human U373 astrocytoma cell line
    J Dunlop
    CNS Disorders, Wyeth Ayerst Research, Princeton, NJ 08543 8000, USA
    Brain Res 839:235-42. 1999
    ..Transcripts for both the EAAT1 and EAAT3 transporter subtypes were detected but not for EAATs 2, 4, and 5...
  33. pmc Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange
    O Warr
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 514:783-93. 1999
    ..in the Bergmann glia ensheathing the Purkinje cells), nor did it block the current produced by EAAT4 and EAAC1 glutamate transporters in Purkinje cells...
  34. doi Corticosterone decreases the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes
    Maehwa Kang
    Department of Anesthesiology, Seoul National University College of Medicine, Seoul, South Korea
    Steroids 75:1113-8. 2010
    ..We investigated the effects of corticosterone on the activity of a glutamate transporter, excitatory amino acid carrier 1 (EAAC1; also called excitatory amino acid transporter type 3 [EAAT3]), and the roles of protein ..
  35. ncbi Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
    D Trotti
    Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Brain Res 914:196-203. 2001
    ..direct activation of protein kinases C or A modulates the activity of the sodium-dependent glutamate transporter EAAC1. EAAC1 modulation was studied in cRNA-injected Xenopus oocytes by measuring [3H]L-glutamate uptake or glutamate-..
  36. ncbi Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 24:4551-9. 2004
    ..these transporters, we examined mGluR1 EPSCs in mice lacking GLAST (for glutamate-aspartate transporter; EAAT1) or EAAC1 (for excitatory amino acid carrier; EAAT3)...
  37. pmc Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter
    Shlomit Teichman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Gen Physiol 129:527-39. 2007
    ..One of these, aspartate-444 of the neuronal glutamate transporter EAAC1, is conserved in glutamate transporters, but a serine residue occupies this position in DctA transporters...
  38. ncbi Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells
    Monica Palmada
    Department of Epithelial Cell Physiology, Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Neurochem Int 40:321-6. 2002
    ..that low concentrations of benzodiazepines stimulate the transport activity of the neuronal glutamate transporter EAAT3, whereas high concentrations inhibit it...
  39. doi The expression of glutamate transporters in chest compression-induced audiogenic epilepsy: a comparative study
    Zhaofeng Lu
    Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Neurol Res 30:915-9. 2008
    This study was conducted to compare the expression of three glutamate transporter subtypes (GLAST, GLT-1 and EAAC1) in rats undergoing chest compression-induced global cerebral ischemia in the presence and absence of cerebral ischemia-..
  40. doi Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:1196-208. 2009
    ..b>SLC1A1 and SLC7A5 mRNAs were most abundant in LE/sGE and GE...
  41. ncbi Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice
    T Mennini
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Neurol Sci 157:31-6. 1998
    ..Spinal EAAC1 glutamate transporter protein was significantly decreased in some but not all aged mice by 36% on average, ..
  42. pmc Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury
    Nicola King
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Physiol 556:849-58. 2004
    ..b>EAAT3 protein expression in isolated cells and vesicles from normal and hypertrophied hearts was investigated by Western ..
  43. ncbi Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures
    J C Jen
    Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurology 65:529-34. 2005
    ..Mutant gene products of both CACNA1A and ATP1A2 may affect neurotransmission of glutamate, the most abundant excitatory amino acid neurotransmitter...
  44. doi Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation
    S Lortet
    IC2N IBDML, Centre National de la Recherche Scientifique, UMR 6216, Parc Scientifique et Technologique de Luminy, Marseille Cedex 09, France
    Neurochem Int 52:1373-82. 2008
    ..neurotransmitter is removed from the synaptic cleft by high affinity amino acid transporters located on neurons (EAAC1) and astrocytes (GLAST and GLT1), and a coordinated action of these cells is necessary in order to regulate ..
  45. ncbi A carboxyl-terminal determinant of the neuronal glutamate transporter, EAAC1, is required for platelet-derived growth factor-dependent trafficking
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 281:4876-86. 2006
    The neuronal glutamate transporter, EAAC1 (excitatory amino acid carrier 1), undergoes rapid regulation after treatment with platelet-derived growth factor (PDGF) or phorbol ester in C6 glioma cells and neurons...
  46. ncbi Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 282:29855-65. 2007
    The sodium-dependent glutamate transporter, excitatory amino acid carrier 1 (EAAC1), has been implicated in the regulation of excitatory signaling and prevention of cell death in the nervous system...
  47. ncbi Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1
    Marco I Gonzalez
    Departments of Pediatrics and Pharmacology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 103:1917-31. 2007
    The neuronal glutamate transporter, excitatory amino acid carrier 1 (EAAC1), has a diverse array of physiologic and metabolic functions...
  48. doi The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein alpha-adducin
    M G Bianchi
    Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Parma, Italy
    Neuroscience 169:584-95. 2010
    b>Excitatory amino acid carrier 1 (EAAC1) belongs to the family of the Na(+)-dependent glutamate carriers...
  49. ncbi Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain
    M Velaz-Faircloth
    Department of Pharmacology, Duke University, Durham, North Carolina 27710, USA
    Am J Physiol 270:C67-75. 1996
    ..glutamate transporters; two are thought to be primarily glial in origin (GLAST and GLT-1) and the third (EAAC1) is localized to neurons in the brain and other nonneural tissues...
  50. ncbi Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury
    Jae Hyuk Yi
    Department of Medicine, Hopital Saint Luc, University of Montreal, Montreal, Quebec, Canada
    Glia 49:121-33. 2005
    ..percussion on the levels of the glutamate transporter proteins GLT-1alpha, its splice variant GLT-1v, GLAST, and EAAC1 in the rat in order to evaluate their pathogenetic role in this model of traumatic brain injury (TBI)...
  51. ncbi Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2
    John Dunlop
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
    Mol Pharmacol 68:974-82. 2005
    ..WAY-213613 was the most selective of the compounds examined, with IC(50) values for inhibition of EAAT1 and EAAT3 of 5 and 3.8 microM, respectively, corresponding to a 59- and 45-fold selectivity toward EAAT2...
  52. ncbi Dietary protein quality and feed restriction influence abundance of nutrient transporter mRNA in the small intestine of broiler chicks
    Elizabeth R Gilbert
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 138:262-71. 2008
    ..acid transporter [Na+-independent cationic and zwitterionic amino acid transporter (b(o,+)AT), excitatory amino acid transporter 3 (EAAT3), Na+-independent cationic and Na+-dependent neutral amino acid transporter (y+ LAT2), and ..
  53. doi Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1
    Saori Akiduki
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566
    J Biol Chem 283:31323-32. 2008
    ..protein 3-18 (GTRAP3-18), a putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1)...
  54. doi Functions of glutamate transporters in cerebellar Purkinje cell synapses
    Y Takayasu
    Department of Otolaryngology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Acta Physiol (Oxf) 197:1-12. 2009
    ..Four distinct glutamate transporters, GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3 and EAAT4, are distributed in the molecular layer of the cerebellum, especially near glutamatergic synapses ..
  55. doi Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice
    Kazuhiko Namekata
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neurosci Lett 465:160-4. 2009
    ..retina, glutamate/aspartate transporter (GLAST) is localized to Müller glial cells, whereas excitatory amino acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs...
  56. pmc Muscarinic receptor stimulation of D-aspartate uptake into human SH-SY5Y neuroblastoma cells is attenuated by hypoosmolarity
    Daniel J Foster
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    J Pharmacol Exp Ther 333:297-309. 2010
    ..of control) in the uptake of D-aspartate and, concurrently, a cellular redistribution of the excitatory amino acid transporter 3 (EAAT3) to the plasma membrane...
  57. ncbi Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase
    G M Alexander
    Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania 19102 1192, USA
    J Neurochem 74:1666-73. 2000
    ..using intracerebral microdialysis and western immunoblot assays for the glutamate transporters GLT-1, GLAST, and EAAC1. The basal extracellular fluid levels of aspartate, glutamate, glutamine, 3,4-dihydroxyphenylacetic acid, and 5-..
  58. ncbi Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Avenue Hippocrate 54, 1200, Brussels, Belgium
    FEBS Lett 523:224-8. 2002
    The possible modulation of the glutamate transporter EAAC1 by a class A G protein-coupled receptor was studied in transfected C6 glioma cells stably expressing the high-affinity neurotensin receptor NTS1...
  59. ncbi Expression of glutamate transporters in the medial and lateral vestibular nuclei during rat postnatal development
    Gina Devau
    INSERM U432, Universite Montpellier II, CC 089, Place Eugene Bataillon, FR 34095 Montpellier Cedex 5, France
    Dev Neurosci 25:332-42. 2003
    The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks...
  60. ncbi Development of the caput epididymidis studied by expressed proteins (a glutamate transporter, a lipocalin and beta-galactosidase) in the c-ros knockout and wild-type mice with prepubertally ligated efferent ducts
    C E Avram
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, 48129, Munster, Germany
    Cell Tissue Res 317:23-34. 2004
    Expression of a glutamate transporter (EAAC1), a lipocalin (MEP17) and beta-galactosidase (beta-Gal) in histological sections was used to monitor post-natal development of the murine epididymis...
  61. ncbi Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS)
    Cristina Vanoni
    Department of Pharmacology, School of Medicine, C E N D Center of Excellence on Neurodegenerative Diseases, University of Milan, IN CNR Cellular and Molecular Pharmacology Section, Via Vanvitelli 32, 20129 Milano, Italy
    J Cell Sci 117:5417-26. 2004
    ..MDCK cell system showed reduced total glial GLT-1 expression, with no change in the expression of the neuronal EAAC1 glutamate transporter isoform...
  62. ncbi Involvement of glial glutamate transporters in morphine dependence
    Takayuki Nakagawa
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Ann N Y Acad Sci 1025:383-8. 2004
    ..Extracellular glutamate released from nerve terminals is counterbalanced by glutamate transporters in neurons (EAAC1 and EAAT4) and glial cells (GLT-1 and GLAST), thereby modulating the glutamatergic system and protecting neurons ..
  63. doi Acute treatment with diphenyl diselenide inhibits glutamate uptake into rat hippocampal slices and modifies glutamate transporters, SNAP-25, and GFAP immunocontent
    Ana P Ardais
    Laboratory of Studies on the Purinergic System, Post Graduation Program in Biological Sciences Biochemistry, Department of Biochemistry, Health and Basic Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre RS, Brazil
    Toxicol Sci 113:434-43. 2010
    ..of glial (glutamate/aspartate transporter [GLAST] and glutamate transporter type I [GLT1]), neuronal (excitatory amino acid carrier 1 [EAAC1]), and vesicular (vesicular glutamate transporter 1 [VGLUT1]) glutamate transporters...
  64. doi Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium
    Marlyn P Langford
    Department of Ophthalmology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Curr Eye Res 35:202-11. 2010
    ....
  65. ncbi Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures
    Charlotte E Teunissen
    European Graduate School of Neuroscience EURON, Universiteit Maastricht, Department of Psychiatry and Neuropsychology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Brain Res 931:5-20. 2002
    ..In addition, staining of EAAC1, anti-2',3'-cyclic nucleotide 3'-phosphohydrolase and ED1 was diminished after treatment of spheroid cultures with ..
  66. ncbi Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function
    Matthew E R Butchbach
    Department of Neuroscience, Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Biol Chem 279:34388-96. 2004
    ..These effects were also observed in neuronal glutamate transporter EAAT3 but to a lesser extent...
  67. ncbi Glutamate transporter localization does not correspond to the temporary functional recovery and late degeneration after acute ocular ischemia in rats
    Nigel L Barnett
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Exp Eye Res 79:513-24. 2004
    ..To determine whether the localization of retinal glutamate transporters is affected by retinal ischaemia and whether their ability to transport glutamate decreases with the progression of ischemic retinal and optic nerve degeneration...
  68. pmc H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    David T Thwaites
    Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Exp Physiol 92:603-19. 2007
    ..SLC46A1); the sodium-glucose linked cotransporter SGLT1 (SLC5A1); and the excitatory amino acid carrier EAAC1 (SLC1A1)...
  69. ncbi Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus: an in situ hybridization analysis
    R Torp
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Anat Embryol (Berl) 195:317-26. 1997
    ..cortex and thalamus of the mRNAs encoding the glutamate transporters GLT1 and rEAAC1 (a rat homologue of rabbit EAAC1) were investigated by nonautoradiographic in situ hybridization using digoxigenin-labelled riboprobes...
  70. ncbi Diversity of glutamate transporter expression and function in the mammalian retina
    T Rauen
    Max Planck Institut für Hirnforschung, Frankfurt, Federal Republic of Germany
    Amino Acids 19:53-62. 2000
    ..GLAST1, GLT1, EAAC1 and EAAT5 are expressed in the retina and exhibit unique localisation and functional properties...
  71. ncbi Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression
    Matthew E R Butchbach
    Department of Neuroscience, Ohio State Biochemistry Program, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210 1239, USA
    J Neurochem 84:891-4. 2003
    The Na+-dependent glutamate transporter EAAT3 facilitates glutamate uptake into neurons as well as many other cell types...
  72. ncbi Expression profile of addicsin/GTRAP3-18 mRNA in mouse brain
    Koutarou Inoue
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 386:184-8. 2005
    ..protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). The other molecular functions of addicsin, however, remain largely unknown...
  73. ncbi Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007
    ..the anticonvulsant ketogenic diet (KD) results in increased mRNA expression of the neuronal glutamate transporter EAAC1, elevated energy reserves, and an increased resistance to seizures in rats...
  74. ncbi Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex
    Pasqualina Castaldo
    Section of Pharmacology, Department of Neuroscience, School of Medicine, Universita Politecnica delle Marche, Via Tronto 10 A, 60020 Ancona, Italy
    Neuropharmacology 53:369-78. 2007
    ..revealed that prenatal WIN exposure enhanced the expression of glutamate transporter 1 (GLT1) and excitatory amino acid carrier 1 (EAAC1)...
  75. ncbi [Role of glutamate transporters in excitatory synapses in cerebellar Purkinje cells]
    Seiji Ozawa
    Regent Office, Gunma University, 4 2 Aramaki, Maebashi, Gunma 371 8510, Japan
    Brain Nerve 59:669-76. 2007
    ..In the CNS, five distinct glutamate transporters (GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4 and EAAT5) have been cloned...
  76. ncbi Genetics of obsessive-compulsive disorder: a research update
    Marco Grados
    The Johns Hopkins University, CMSC 346, Baltimore, MD 21287 3325, USA
    Expert Rev Neurother 7:967-80. 2007
    ..while promising, are not yet associated with linkage regions, except in the case of the glutamate transporter gene SLC1A1 in 9p24...
  77. pmc Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
    Liling Yang
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 75 Parkman Street, Boston, MA 02114, USA
    J Biol Chem 283:21703-13. 2008
    ..we show that chronic morphine exposure induced posttranscriptional down-regulation of the glutamate transporter EAAC1 in C6 glioma cells with a concurrent decrease in glutamate uptake and increase in proteasome activity, which were ..
  78. pmc Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia
    Deborah Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, United States
    Schizophr Res 104:108-20. 2008
    ..To test this, we measured expression of EAAT1, EAAT2, EAAT3, and EAAT interacting proteins in postmortem tissue from the dorsolateral prefrontal and anterior cingulate cortex ..
  79. pmc Critical role of s465 in protein kinase C-increased rat glutamate transporter type 3 activity
    Hee Jung Baik
    Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA
    Int J Neurosci 119:1419-28. 2009
    ..Activation of protein kinase C (PKC) increases the activity of EAAT type 3 (EAAT3), the major neuronal EAAT...
  80. pmc Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus
    Annalisa Scimemi
    Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 29:14581-95. 2009
    ..Here we show that EAAC1, the predominant neuronal glutamate transporter at excitatory synapses in hippocampal area CA1, buffers glutamate ..
  81. pmc Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats
    Thomas J Crisman
    Computational Structural Biology Group, The Max Planck Institute of Biophysics, Max von Laue Strasse 3, 60438 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 106:20752-7. 2009
    ..To test this model, we introduced pairs of cysteines into the neuronal glutamate transporter EAAC1, at positions that are >27 A apart in the crystal structures of GltPh, but approximately = 10 A apart in the ..
  82. doi Co-administration of ultra-low dose naloxone attenuates morphine tolerance in rats via attenuation of NMDA receptor neurotransmission and suppression of neuroinflammation in the spinal cords
    Shinn Long Lin
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    Pharmacol Biochem Behav 96:236-45. 2010
    ..5days induced (1) antinociceptive tolerance, (2) downregulation of glutamate transporters (GTs) GLT-1, GLAST, and EAAC1, (3) increasing of NMDA receptor (NMDAR) NR1 subunit expression and phosphorylation, (4) upregulation of protein ..
  83. doi Neurosteroid allopregnanolone regulates EAAC1-mediated glutamate uptake and triggers actin changes in Schwann cells
    Carla Perego
    Department of Molecular Sciences Applied to Biosystems, Universita degli Studi di Milano, Milan, Italy
    J Cell Physiol 227:1740-51. 2012
    ..We first demonstrate that Schwann cells express the EAAC1 transporter in the plasma membrane and in intracellular vesicular compartments of the endocytic recycling pathways...
  84. pmc Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse
    Weinan Sun
    Center for Structural and Functional Neuroscience, The University of Montana, Missoula, Montana, United States of America
    PLoS ONE 6:e23765. 2011
    ..Although L-TBA exhibited approximately four-fold selectivity for neuronal EAAT3 over glial EAAT1/EAAT2 transporter subtypes expressed in Xenopus oocytes, the L-TBA concentration-dependence of ..
  85. doi Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation
    Bo Zhao
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Molecules 17:2725-37. 2012
    ..extracellular glutamate content and markedly prevented the effects induced by OGD on protein level of GLT-1 and EAAC1 glutamate transporters. In addition, it reduced intracellular ROS generation...
  86. doi GABA, glutamate, dopamine and serotonin transporters expression on forgetting
    Ruth Tellez
    Depto de Farmacobiología, Mexico
    Neurobiol Learn Mem 98:66-77. 2012
    ..Hence, in this paper western-blot analysis was used to evaluate expression of GAT1, EAAC1, DAT and SERT during forgetting in trained and untrained rats treated with the selective serotonin transporter ..
  87. doi Changes in relative organ weights and intestinal transporter gene expression in embryos from White Plymouth Rock and WENS Yellow Feather Chickens
    Xiang Guang Li
    College of Animal Science, South China Agricultural University, Guangzhou, 510642, PR China
    Comp Biochem Physiol A Mol Integr Physiol 164:368-75. 2013
    ..The levels of gene expression of SLC7A9, SLC1A1 and SLC15A1 in the small intestine increased during embryo development and were affected by breed...
  88. pmc Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1
    Juddy Mwaura
    Department of Chemistry, Binghamton University, Binghamton, NY 13902, USA
    ACS Chem Neurosci 3:1073-83. 2012
    ..While the kinetics of Na(+)/glutamate exchange were slowed, the apparent valence (z) of the charge moved in EAAC1 D454N (0.71) was similar to that of EAAC1 WT (0.64)...
  89. pmc Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism
    Jiao Deng
    Department of Anesthesiology, University of Virginia Health System, 1 Hospital Drive, PO Box 800710, Charlottesville, VA, 22908 0710, USA
    Transgenic Res 22:757-66. 2013
    ..We showed that EAAT type 3 (EAAT3) knockout mice had a slower heart rate than wild-type mice when they were anesthetized...
  90. pmc Gliopreventive effects of guanosine against glucose deprivation in vitro
    André Quincozes-Santos
    Departamento de Bioquimica, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Anexo Bairro Santa Cecília, 90035 003, Porto Alegre, Rio Grande do Sul, Brazil
    Purinergic Signal 9:643-54. 2013
    ..Glucose deprivation decreased the level of EAAC1, the main glutamate transporter present in C6 cells...
  91. pmc Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus
    Meredith C Lane
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurochem Int 73:152-8. 2014
    b>Excitatory amino acid carrier 1 (EAAC1 also called EAAT3) is a Na(+)-dependent glutamate transporter expressed by both glutamatergic and GABAergic neurons...
  92. pmc Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking
    Jiangbei Cao
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22903, USA Department of Anesthesiology and Operation Center, Chinese PLA General Hospital, Beijing 100853, China
    Biochim Biophys Acta 1840:1640-5. 2014
    ..GluR1 is an AMPAR subunit. We have shown that mice with knockout of excitatory amino acid transporter type 3 (EAAT3), a neuronal glutamate transporter, have impaired learning and memory...
  93. doi Identification of tomoregulin-1 as a novel addicsin-associated factor
    Taku Arano
    Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan Department of Biomolecular Science, Graduate School of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Neurochem Int 71:22-35. 2014
    ..protein 3-18 (GTRAP3-18), a negative modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1)...
  94. pmc A critical role of glutamate transporter type 3 in the learning and memory of mice
    Zhi Wang
    Department of Anesthesiology, University of Virginia, Charlottesville, VA, United States Department of Anesthesiology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Neurobiol Learn Mem 114:70-80. 2014
    ..learning and memory are associated with trafficking of excitatory amino acid transporter type 3 (EAAT3) to the plasma membrane...
  95. pmc Renin-angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma
    K Semba
    1 Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan 2 Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Cell Death Dis 5:e1333. 2014
    ..In the mammalian retina, excitatory amino acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs, and the loss of EAAC1 leads to RGC degeneration ..
  96. pmc Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons
    Suzanne M Underhill
    Laboratory of Molecular and Cellular Neurobiology, NIH NIMH, Bethesda, MD 20892, USA Electronic address
    Neuron 83:404-16. 2014
    ..neurons through the dopamine transporter, it stimulates endocytosis of an excitatory amino acid transporter, EAAT3, in dopamine neurons...
  97. doi Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence
    Chris Pickering
    University of Gothenburg, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, Department of Psychiatry and Neurochemistry, Addiction Biology Unit, Gothenburg, Sweden Electronic address
    Pharmacol Biochem Behav 132:63-70. 2015
    ..of brain-derived neurotrophic factor, NMDA NR2A subunit, mGluR8 receptor, Homer1, the glutamate transporters SLC1a1 and SLC1a6 and Srr...
  98. doi Gabapentin inhibits the activity of the rat excitatory glutamate transporter 3 expressed in Xenopus oocytes
    Yang Sook Gil
    Department of Anesthesiology and Pain Medicine, Bestian Hospital, Seoul 939 24, Republic of Korea
    Eur J Pharmacol 762:112-7. 2015
    ..We investigated the effect of gabapentin on the activity of excitatory amino acid transporter 3 (EAAT3) that can regulate extracellular glutamate concentrations...
  99. pmc Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats
    Jennifer C Arnold
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, United States
    ACS Chem Neurosci 7:227-39. 2016
    ..This exercise regimen did not affect glutamate uptake or glutamate transporter expression in striatum. However, EAAC1 expression increased in SN...
  100. doi Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms
    Matheus Figueiredo Sathler
    Laboratorio de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Niteroi, Brazil Electronic address
    Neuroscience 329:326-36. 2016
    ..cAMP-mediated activation of PKA and phosphorylation of the excitatory amino acid transporters EAAT1, EAAT2 and EAAT3. We also demonstrated that cocaine exposure increases extracellular d-aspartate, l-glutamate and d-serine in the ..
  101. ncbi Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 773:139-48. 1997
    ..to amino acid residues 161-177 of the deduced sequence of the human neuron-specific glutamate transporter III (EAAC1)...

Research Grants55

  1. CHARLES KENNETH MESHUL; Fiscal Year: 2016
    ..We also find MPTP-induced changes in several glutamate transporter markers within the CPu ([unreadable]VGLUT 1, EAAC1, GLAST) and SN ('VGLUT 1/2, EAAC1, GLAST, GLT-1) that would be consistent with the decrease or increase in ..
  2. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2012
    ..we wish to pursue the hypothesis that RNA for the predominant forebrain neuronal glutamate transporter (called EAAC1 or EAAT3) is targeted to dendrites, that this targeting is dependent upon portions of the 3'untranslated ..
  3. Stephen W Scherer; Fiscal Year: 2016
    ..and the Arnold and Kennedy groups demonstrate a significant association of the glutamate transporter gene, SLC1A1, and glutamate receptor gene, GRIN2B, with early-onset OCD...
  4. Marian DiFiglia; Fiscal Year: 2014
    ..One neuron specific cargo affected in HD neurons is the cysteine/glutamate transporter. In HD neurons, EAAC1 dependent uptake of cysteine is impaired leading to insufficient glutathione synthesis, elevated ROS and cell ..
  5. High-Level Expression of Human EAAT3 for Biochemical and Structural Analysis
    DIANNE LYNN DECAMP; Fiscal Year: 2011
    ..Development of effective inhibitors is impeded by lack of a recombinant expression system for EAAT3. Current methods to assay the transporter activity of EAATs are cumbersome, and the lack of high-resolution ..
  6. Molecular Basis of Glutamate Transport
    CHRISTOF THEODOR GREWER; Fiscal Year: 2012
    ..Aim 3 will comparatively analyze the functional properties of the neuronal glutamate transporter subtypes EAAT3, EAAT4 and EAAT5 and establish the role of the C-terminus in the regulation of EAAT5 activity...
  7. JoEllen Welsh; Fiscal Year: 2014
    ..Through genomic profiling, we identified SLC1A1 (a glutamate transporter) and GLUL (glutamine synthetase) as vitamin D regulated genes suggesting that, like p53, ..
  8. Translating OCD gene-association studies into mice to examine SLC1A1 function
    Jeremy Veenstra-Vanderweele; Fiscal Year: 2013
    ..To date, the only gene which has been consistently linked to OCD in human genetic studies is SLC1A1, which codes for a protein that transports the neurotransmitter glutamate...
  9. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    Michael Robinson; Fiscal Year: 2006
    ..within min) changes both the activity and cell surface expression of the three forebrain glutamate transporters, EAAC1, GLT-1, and GLAST...
  10. Disruption of an epigenetic locus controlling EAAC1 expression in schizophrenia
    Marina Myles-Worsley; Fiscal Year: 2013
    ..This epigenetic locus is adjacent to the EAAC1 (excitatory-amino-acid-carrier-1) glutamate transporter gene, which plays an essential role in regulating ..
  11. PROPERTIES AND ROLES OF EXCITATORY AMINO ACID TRANSPORT
    Richard Bridges; Fiscal Year: 2006
    ..AIM III Develop novel glutamate analogues as pharmacological and functional probes of EAAT3. AIM IV Conduct SAR studies on EAAT 1, 4 and 5 using conformationally constrained analogues...
  12. EAAC1 Transporter Associated Protein, GABA & Epilepsy
    JEHUDA SEPKUTY; Fiscal Year: 2003
    Decreasing the expression of the neuronal glutamate transporter, EAAC1, causes epilepsy in adult rats...
  13. MOLECULAR BIOLOGY OF BRUSH BORDER TRANSPORT PROTEINS
    Matthias Hediger; Fiscal Year: 1999
    ..SGLTI and SGLT2, the Na+ and K+-dependent neuronal and epithelial high affinity glutamate transporter EAAC1, the intestinal H+-coupled oligopeptide transporter PepT1 and its renal isoform hPepT2, and the renal facilitated ..
  14. NEURONAL GLUTAMATE TRANSPORTER ASSOCIATED PROTEINS(GTRAP
    Jeffrey Rothstein; Fiscal Year: 2004
    ..interact with the major intracellular domains of the two neuronal glutamate transporter subtypes: EAAT4 and EAACI (EAAT3)...
  15. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..our lab have identified a critical role for the cysteine/glutamate uptake transporter EAAT3 (excitatory amino acid transporter 3) in controlling redox and methylation status in human neuronal cells...
  16. Ariel Y Deutch; Fiscal Year: 2016
    ..proteins will be compared to changes in neuronal proteins (including VGluT1 and 2, GluN1 and 2, GluA1 and 2, and EAAC1) involved in glutamatergic transmission...
  17. Role of the Solute Carrier Gene Family in Hypertension
    Alanna C Morrison; Fiscal Year: 2012
    ..Based on replication across cohorts and a meta-analysis of results, the SLC1A1 gene was significantly associated with diastolic blood pressure levels and the SLC6A13 gene was significantly ..
  18. Shimon Schuldiner; Fiscal Year: 2014
    ..These are GLT-1 and EAAC1, the (Na+ + K+)-coupled plasma membrane transporters of the neurotransmitter glutamate, and rVMAT2, a vesicular H+-..
  19. MECHANISMS OF ACTIVE NEUROTRANSMITTER TRANSPORT
    Shimon Schuldiner; Fiscal Year: 2009
    ..These are GLT-1 and EAAC1, the (Na+ + K+)-coupled plasma membrane transporters of the neurotransmitter glutamate, and rVMAT2, a vesicular H+-..
  20. GLUTAMATE TRANSPORTERS--ALTERATIONS IN SPINAL CORD INJUR
    Susan Queen; Fiscal Year: 1999
    ..1c) The anatomical specificity of the Na-dependent subtypes EAAC1,GLT-1 and GLAST will be determined by immunohistochemistry with primary antibodies specific to each subtype and ..
  21. Dynamic regulation of inhibitory synaptic transmission through GABA metabolism
    GREGORY MATHEWS; Fiscal Year: 2009
    ..inhibitory neurons is regulated by the supply of its precursor glutamate through direct uptake via Excitatory Amino Acid Transporter 3 (EAAT3], and uptake of glutamine, which can be deamidated in neurons to produce glutamate, via ..
  22. PGDF-Dependent Regulation of EAAC1
    Amanda Sheldon; Fiscal Year: 2006
    ..b>EAAC1, a neuronal subtype, is enriched in the hippocampus and cortex, areas that are extremely sensitive to excitotoxic ..
  23. EAAT3 Contribution to Glutamate Uptake in the Hippocampus
    Melissa Herman; Fiscal Year: 2009
    ..Deciphering the role played by neuronal glutamate transporters in the hippocampus will provide useful insight into normal brain function and prevention of excess glutamate neurotoxicity. ..
  24. GLUTAMATE TRANSPORT AND TRANSPORTERS FOREBRIAN NEURONS
    Paul Rosenberg; Fiscal Year: 2004
    ..culture, and found that the pharmacology of glutamate transport was distinct from that of the neuronal transporter EAAC1, and resembled that of GLT1, known as an astrocyte transporter...
  25. Expression and Function of the EAATs in the Heart
    JOHN RALPHE; Fiscal Year: 2009
    ..His preliminary data has demonstrated the presence of EAAT1, EAAT2, and EAAT3 in cardiomyocytes, with EAAT1 localizing to the inner mitochondrial membrane...
  26. Transcription Factors & Inflammatory Mediators in Stroke
    Raghu Vemuganti; Fiscal Year: 2007
    ..The ultimate goal is to define the role of SOCS-3/STAT-3 in post-ischemic cerebral inflammation. ..
  27. MOLECULAR MECHANISMS OF PLACENTAL AMINO ACID TRANSPORT
    Donald Novak; Fiscal Year: 2002
    ..the major focus upon transport proteins known to participate in the placental transfer of glutamate, specifically EAAC1, GLT1, and GLAST1, responsible for Na+-dependent anionic amino acid transport via System X-AG...
  28. Diet Impacts Nutrient Transfer to Subsequent Generations
    Donald Novak; Fiscal Year: 2004
    ..abstract_text> ..
  29. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  30. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004
    ....
  31. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..Dr. Yao, PI, has been collaborating with a research group at CCSYSU in this Chinese population and recently reported evidence of linkage to chromosome 4 from a genome-wide search for susceptibility gene. ..
  32. Neuroprotection after Isoflurane Preconditioning
    Zhiyi Zuo; Fiscal Year: 2007
    ..Since isoflurane has been used safely in clinical practice for many years, IsoP may prove to be a useful clinical method to reduce ischemic brain injury. ..
  33. The Role of Toll-Like Receptors in NPC
    YIN YAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. HORMONAL REGULATION OF PROSTATE CITRATE PRODUCTION
    RENTY FRANKLIN; Fiscal Year: 2003
    ..abstract_text> ..
  35. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  36. Novel, in Vivo Measures of Rat Spinal Cord Glutamate
    Susan Queen; Fiscal Year: 2007
    ..It will be essential to validate the technique in rat spinal cord prior to application of the method to spinal cord injury. [unreadable] [unreadable]..
  37. EXCITATORY SYNAPTIC SIGNALING BY GLUTAMATE TRANSPORTERS
    Thomas Otis; Fiscal Year: 2004
    ..The findings should also lead to a better understanding of glutamate synapses and provide insight into diseases associated with malfunctions in excitatory transmission such as epilepsy and Amyotrophic Lateral Sclerosis. ..
  38. Molecular mechanisms of glutamate transporters
    Hans Peter Larsson; Fiscal Year: 2008
    ....
  39. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  40. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  41. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  42. FAMILY-GENETIC STUDY OF YOUTH AT RISK FOR SCHIZOPHRENIA
    Marina Myles Worsley; Fiscal Year: 2007
    ..abstract_text> ..
  43. Cortical Plasticity after Hemispherectomy
    Gary Mathern; Fiscal Year: 2006
    ..abstract_text> ..
  44. Molecular mechanisms of voltage-gated ion channels
    Hans Peter Larsson; Fiscal Year: 2006
    ..These measurements will be used to determine how S4 moves in the different channels and will further our understanding of the different mechanisms of opening of these two classes of channels. ..
  45. Protein-based sensors of excitatory synaptic activity
    Thomas Otis; Fiscal Year: 2006
    ..A series of constructs based on fusion of a neuronal glutamate transporter (EAAT3 or EAAT4) and ion-sensitive variants of GFP will be generated. Sensor constructs will be evaluated in three stages...
  46. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  47. Genetics of Schizophrenia in Oceanic Palau.
    Marina Myles Worsley; Fiscal Year: 2009
    ..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, research team and the novelty of hypotheses and approach. ..
  48. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  49. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  50. TRAFFICKING OF A NEURONAL GLUTAMATE TRANSPORTER, EAAC1
    Michael Robinson; Fiscal Year: 2008
    ..We and others have found that the activity of one of these transporters, called EAAC1, can be rapidly increased by either activation of protein kinase C (PKC) or the platelet-derived growth factor ..
  51. Molecular Basis of Glutamate Transport
    Christof Grewer; Fiscal Year: 2008
    ..to be tested is that EAAT5 is a slowly-gated anion channel with little transport activity, in contrast to EAAT3 and EAAT4, which both readily transport glutamate...
  52. ZINC TRANSPORT RELATIONSHIPS IN PROSTATE CANCER CELLS
    RENTY FRANKLIN; Fiscal Year: 2008
    ..4. To determine if decreases expression of ZIP1 and decreased zinc accumulation are characteristics of malignant cells in prostate cancer. ..
  53. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..