Gene Symbol: SLC17A5
Description: solute carrier family 17 (acidic sugar transporter), member 5
Alias: AST, ISSD, NSD, SIALIN, SIASD, SLD, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter, membrane glycoprotein HP59, sialic acid storage disease, sialin, sodium/sialic acid cotransporter, solute carrier family 17 (anion/sugar transporter), member 5, vesicular H(+)/Aspartate-glutamate cotransporter
Species: human

Top Publications

  1. ncbi Pruritus in chronic hepatitis C: association with high serum bile acids, advanced pathology, and bile duct abnormalities
    E Lebovics
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    Dig Dis Sci 42:1094-9. 1997
  2. ncbi [Five cases of erythema infectiosum in adults]
    T Takahashi
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 75:469-72. 2001
  3. ncbi Prevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitals
    S Fujioka
    First Department of Internal Medicine, Okayama University Medical School
    Kansenshogaku Zasshi 72:5-11. 1998
  4. ncbi Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats
    Ismail Celik
    Faculty of Art and Science, Department of Biology, Yuzuncu Yil University, Van, Turkey
    Nat Prod Res 22:66-75. 2008
  5. ncbi Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
  6. ncbi [A case of neonatal herpes infection which proved to be a mixed infection of herpes simplex virus type 1 and type 2]
    Y Minohara
    Department of Pediatrics, St. Marianna University, School of Medicine
    Kansenshogaku Zasshi 70:627-30. 1996
  7. ncbi Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion
    G den Butter
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    Transpl Int 8:466-71. 1995
  8. ncbi Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severity
    Robert Kleta
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Mol Genet Metab 82:137-43. 2004
  9. ncbi Relationship of the subgingival microbiota to a chairside test for aspartate aminotransferase in gingival crevicular fluid
    M Y Wong
    School of Dentistry, College of Medicine, National Taiwan University, Taipei
    J Periodontol 70:57-62. 1999
  10. ncbi Changes in vitamin E concentration after surgery and anesthesia
    J Zunic
    Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
    Coll Antropol 21:327-34. 1997

Detail Information

Publications164 found, 100 shown here

  1. ncbi Pruritus in chronic hepatitis C: association with high serum bile acids, advanced pathology, and bile duct abnormalities
    E Lebovics
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    Dig Dis Sci 42:1094-9. 1997
    ..Pruritus was present in nine (5.1%) patients. Serum AST, ALT, alkaline phosphatase, GGTP, total bilirubin, and ferritin were similar in pruritics and controls...
  2. ncbi [Five cases of erythema infectiosum in adults]
    T Takahashi
    Department of Medicine, Yame General Hospital
    Kansenshogaku Zasshi 75:469-72. 2001
    ..Rheumatoid factor (RF) was also detected by latex fixation test. Her AST was 51 IU/L, ALT 68 IU/L and LDH 568 IU/L...
  3. ncbi Prevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitals
    S Fujioka
    First Department of Internal Medicine, Okayama University Medical School
    Kansenshogaku Zasshi 72:5-11. 1998
    ..05). Transaminase levels were higher in group 1 (median (range) IU/l of AST, ALT; 29 (13-95), 32 (9-144) and group 3 (25 (15-187), 22 (8-185)) than in group 4 (18 (9-13), 15 (6-133); p < 0...
  4. ncbi Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats
    Ismail Celik
    Faculty of Art and Science, Department of Biology, Yuzuncu Yil University, Van, Turkey
    Nat Prod Res 22:66-75. 2008
    ..of the plant infusions were evaluated by measuring levels of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), creatine phosphokinase (CPK), acid phosphatase (ACP), alkaline phosphatase (ALP) ..
  5. ncbi Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
    ..Glucose tolerance tests (GTT), intravenous insulin tolerance tests (IVITT), arginine stimulation tests (AST) and glucose clamp studies before and during GH suppression with somatostatin were performed in a group of patients ..
  6. ncbi [A case of neonatal herpes infection which proved to be a mixed infection of herpes simplex virus type 1 and type 2]
    Y Minohara
    Department of Pediatrics, St. Marianna University, School of Medicine
    Kansenshogaku Zasshi 70:627-30. 1996
    ..b>AST was 1042 IU/L, and ALT 206 IU/L. In spite of treatment, the patient died at the age of 12 days...
  7. ncbi Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion
    G den Butter
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    Transpl Int 8:466-71. 1995
    ..LDH and AST release were greater in HTK-preserved livers than in UW livers, but these differences were not statistically ..
  8. ncbi Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severity
    Robert Kleta
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Mol Genet Metab 82:137-43. 2004
    The allelic autosomal recessive lysosomal storage disorders Salla disease and infantile free sialic acid storage disease (ISSD) result from mutations in SLC17A5...
  9. ncbi Relationship of the subgingival microbiota to a chairside test for aspartate aminotransferase in gingival crevicular fluid
    M Y Wong
    School of Dentistry, College of Medicine, National Taiwan University, Taipei
    J Periodontol 70:57-62. 1999
    The aim of the present study was to evaluate the association between the occurrence of certain specific periodontal pathogens and aspartate aminotransferase (AST) levels in gingival crevicular fluid (GCF).
  10. ncbi Changes in vitamin E concentration after surgery and anesthesia
    J Zunic
    Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia
    Coll Antropol 21:327-34. 1997
    ..Simultaneously activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) were determined. Statistical analysis: ANOVA, Tukay HSD test...
  11. ncbi Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT
    L G Larsson
    Department of Neuropharmacology, CNS 1, Astra Research Centre, , Sweden
    Neuropharmacology 29:85-91. 1990
    ..hippocampus and hypothalamus, after inhibition of L-aromatic amino acid decarboxylase by 3-hydroxybenzylhydrazine (NSD 1015), that is due to stimulation of autoreceptors on the 5-HT cell bodies...
  12. ncbi Prenatal diagnosis of free sialic acid storage disorders (SASD)
    Nina Aula
    Neuroscience Center, University of Helsinki, Finland
    Prenat Diagn 26:655-8. 2006
    Free sialic acid storage disorders, Salla disease (SD) and Infantile sialic acid storage disease (ISSD), are lysosomal storage diseases due to impaired function of a sialic acid transporter, sialin, at the lysosomal membrane...
  13. ncbi Autonomic stress tests in obstructive sleep apnea syndrome and snoring
    D Veale
    Department of Pneumonology, CHRU, Grenoble, France
    Sleep 15:505-13. 1992
    ..A significant difference between normal abnormal autonomic stress test (AST) groups was observed in the evening and the morning as regards cumulative time spent under 90% SaO2 and minimal ..
  14. pmc The lysosomal sialic acid transporter sialin is required for normal CNS myelination
    Laura M Prolo
    Department of Neurology and Neurological Sciences and Graduate Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:15355-65. 2009
    Salla disease and infantile sialic acid storage disease are autosomal recessive lysosomal storage disorders caused by mutations in the gene encoding sialin, a membrane protein that transports free sialic acid out of the lysosome after it ..
  15. ncbi [Drug-induced hepatotoxicity caused by anti-tuberculosis drugs in tuberculosis patients complicated with chronic hepatitis]
    Yugo Kaneko
    Department of Pulmonary Medicine, Jikei University School of Medicine, 4 11 1, Izumihoncho, Komae shi, Tokyo 201 8601, Japan
    Kekkaku 83:13-9. 2008
  16. ncbi Novel form of intermediate salla disease: clinical and neuroimaging features
    Richard P Morse
    Department of Pediatrics, Division of Pediatric Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Child Neurol 20:814-6. 2005
    ..Infantile sialic acid storage disease has a severe phenotype, and Salla disease (Finnish variant) is generally milder in phenotype; ..
  17. ncbi Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs
    Meghna R Adhvaryu
    Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, 110, Nehru Nagar Society, Ichchhanath Road, Surat 395007, India
    World J Gastroenterol 13:3199-205. 2007
  18. ncbi Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials
    Edwin K Kuffner
    McNeil Consumer Healthcare, Division of McNeil PPC, Inc, Fort Washington, PA 19034, USA
    Curr Med Res Opin 22:2137-48. 2006
    ..9 g daily than in patients receiving placebo, and the rates were higher than aminotransferase values observed in some previous osteoarthritis studies with acetaminophen...
  19. pmc Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B
    Jie Shao
    Department of Hepatic Disease, People s Hospital, Peking University, Beijing 100034, China
    World J Gastroenterol 13:2104-7. 2007
    ..To study the relationship between hepatitis B virus (HBV) DNA levels and liver histology in patients with chronic hepatitis B (CHB) and to determine the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative patients...
  20. doi A pilot study to compare natural health product-drug interactions in two databases in Canada
    Guillaume Faubert
    Pharmacy Department, Pharmaceutical Practice Research Unit, CHU Sainte Justine, 3175, Chemin de la Cote Ste Catherine, Montreal, QC, H3T 1C5, Canada
    Pharm World Sci 32:179-86. 2010
    ..The aim of this article is to evaluate and compare two natural health product databases for the purpose of integrating them into a pharmacy information system in Canada...
  21. ncbi Tissue-specific alterations in insulin-like growth factor-I concentrations in response to 3,3',5-triiodo-L-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken
    R Vasilatos-Younken
    Department of Poultry Science, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
    Gen Comp Endocrinol 105:31-9. 1997
    ..The recessive sex-linked dwarfing (SLD) gene (dw) in chickens results in a lack of functional target tissue GH receptors due to a variety of molecular ..
  22. ncbi [Effects of astragaloside and Panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice]
    Hua Tan
    Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
    Zhong Xi Yi Jie He Xue Bao 8:448-52. 2010
    To investigate the influence of astragaloside (AST) and Panax notoginseng saponins (PNS) combination on oxidative stress of brain tissues in C57BL/6 mice with cerebral ischemia-reperfusion injury.
  23. ncbi Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
    Toxicology 165:217-24. 2001
    ..tetrachloride-induced changes in the activity of alanine amino transferase (ALT), aspartate amino transferase (AST), glutathione S-transferase (GST), and the level of glutathione (GSH) and thiobarbituric acid reactive substances (..
  24. ncbi Early fractionation methods and the origins of the NSD concept
    H D Thames
    Department of Biomathematics, University of Texas System Cancer Center, Houston 77030
    Acta Oncol 27:89-103. 1988
    ..of fraction number and overall time could be separated; these developments constituted the foundation of the Ellis NSD model...
  25. pmc Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats
    Ru Tao Hong
    Department of Geriatrics Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
    World J Gastroenterol 15:1452-8. 2009
    ..To investigate the protective effects of melatonin on carbon tetrachloride (CCl4)-induced hepatic fibrosis in experimental rats...
  26. ncbi Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth
    Giuseppe Perinetti
    Unit of Orthodontics, Department of Oral Sciences, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Clin Periodontol 31:60-7. 2004
    ..of Actinobacillus actinomycetemcomitans (Aa) and alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities in gingival crevicular fluid (GCF) in order to assess whether these parameters have potential as ..
  27. pmc Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes
    Pascal Courville
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 285:19316-23. 2010
    Salla disease and infantile sialic acid storage disorder are human diseases caused by loss of function of sialin, a lysosomal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out ..
  28. pmc Prevalence of enterotoxin genes in Aeromonas spp. isolated from children with diarrhea, healthy controls, and the environment
    M J Albert
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
    J Clin Microbiol 38:3785-90. 2000
    ..Recently, we have characterized a heat-labile cytotonic enterotoxin (Alt), a heat-stable cytotonic enterotoxin (Ast), and a cytotoxic enterotoxin (Act) from a diarrheal isolate of Aeromonas hydrophila...
  29. ncbi High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy
    David Stejskal
    Metabolic and Diabetologic Out Patient Centre and Department of Laboratory Medicine, Hospital Sternberk, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:93-9. 2005
    ..for serum concentrations of AN, glucose, triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamate transferase (GMT) activity; carbohydrate-deficient transferrin (CDT%) a marker of chronic alcohol ..
  30. pmc Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury
    Qing Zhao Shi
    Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 16:897-903. 2010
    ..To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury...
  31. doi Gemfibrozil-induced myositis in a patient with normal renal function
    Martin Hahn
    Tennessee Valley Health Care System, Nashville, TN 37129, USA
    Ann Pharmacother 44:211-4. 2010
    ..To describe a case of gemfibrozil monotherapy-induced myositis in a patient with normal renal function..
  32. pmc Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation
    Miao Xian Dong
    The Institute of Medicine, Qiqihar Medical University, JianHua District, Qiqihar, Heilongjiang Province, China
    World J Gastroenterol 15:4753-62. 2009
    ..To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms...
  33. doi Modulation of key metabolic enzyme of Labeo rohita (Hamilton) juvenile: effect of dietary starch type, protein level and exogenous alpha-amylase in the diet
    Shivendra Kumar
    Department of Fish Nutrition and Biochemistry, Central Institute of Fisheries Education, Versova, Mumbai 400061, India
    Fish Physiol Biochem 35:301-15. 2009
    ..dehydrogenase, G6PD) and amino acid metabolism (alanine amino transferase, ALT and aspartate amino transferase, AST) in Labeo rohita. Three hundred and sixty juveniles (average weight 10 +/- 0...
  34. ncbi Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain
    A Brambilla
    Department of Biology, Boehringer Ingelheim Italia, Milan, Italy
    Eur Neuropsychopharmacol 10:63-7. 1999
    ..5-HTP) after blockade of aromatic amino acid decarboxylase induced by m-hydroxybenzylhydrazine (NSD-1015), at 100 mg/kg i.p., 30 min before sacrifice...
  35. ncbi Heparin sensitivity test for patients requiring cardiopulmonary bypass
    William J DeBois
    New York Presbyterian Hospital Weill Cornell Medical Center, NY 10021, USA
    J Extra Corpor Technol 38:307-9. 2006
    ..An anticoagulation sensitivity test (AST) was developed by adding 12 units of porcine mucosa heparin to the ACT tube (International Technidyne, celite type)...
  36. ncbi Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality
    V Arndt
    Department of Epidemiology, University of Ulm, Germany
    Int Arch Occup Environ Health 71:405-12. 1998
    Gamma-glutamyl transferase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) are widely used as markers of hepatobiliary disorders in occupational health surveillance...
  37. ncbi Comparison of blood aminotransferase methods for assessment of myopathy and hepatopathy in Florida manatees (Trichechus manatus latirostris)
    Kendal E Harr
    FVP Consultants, Inc, Bushnell, Florida 33513, USA
    J Zoo Wildl Med 39:180-7. 2008
    Muscle injury is common in Florida manatees (Trichechus manatus latirostris). Plasma aspartate aminotransferase (AST) is frequently used to assess muscular damage in capture myopathy and traumatic injury...
  38. ncbi Scapholunate dissociation: an experimental kinematic study of two types of indirect soft tissue repairs
    A B Dagum
    Department of Surgery, University of Toronto, Ontario, Canada
    J Hand Surg Am 22:714-9. 1997
    Indirect soft tissue repairs of scapholunate dissociation (SLD) address the pathophysiology but have been criticized for significantly limiting wrist flexion and altering wrist kinematics...
  39. ncbi Nasal septum deviation in newborns
    A Soboczyński
    ORL Clinic, Academy of Medicine, Poznan, Poland
    Acta Otorhinolaryngol Belg 46:263-5. 1992
    The patency of the nose is very important for the newborn. Nasal septum deviation (NSD) is one of the most important factors causing disorders of the patency of the nose. It is usually the result of mechanical trauma...
  40. ncbi [How brain-dead state affects the hepatic morphology and function of Ba-Ma mini pigs and its mechanism]
    Shui jun Zhang
    Department of General Surgery, The First Affiliated Hospital, Zhenzhou University, Zheng Zhou 450052, China
    Zhonghua Yi Xue Za Zhi 86:1244-8. 2006
    ..To investigate the impact of brain death (BD) on the morphology and function of liver...
  41. ncbi Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv)
    F Arguello
    Strong Children s Research Center, University of Rochester School of Medicine, New York 14642
    Cancer Res 52:2304-9. 1992
    ..26 melanoma cells into mutant Sl/Sld and W/Wv mice...
  42. ncbi Protective effects of L-arginine against ischemia-reperfusion injury in non-heart beating rat liver graft
    Jin Gong
    Department of Surgery, First Affiliated Hospital, Jinan University, Guangzhou 510630, China
    Hepatobiliary Pancreat Dis Int 7:481-4. 2008
    ..Prevention of liver injury in NHBDs will benefit the results of transplantation. This study was conducted to evaluate the protective effects of L-arginine on liver grafts from NHBDs...
  43. ncbi Aspartat aminotransferase--a marker of periodontal disease activity
    M Ivić-Kardum
    Department of Periodontology, School of Dental Medicine, Zagreb, Croatia
    Coll Antropol 23:111-6. 1999
    ..Aspartat aminotransferase (AST) activity in gingival crevicular fluid is a potential quantitative marker of periodontal disease activity...
  44. ncbi Safety and efficacy of combined ezetimibe/simvastatin treatment and simvastatin monotherapy in patients with non-alcoholic fatty liver disease
    Tatjana Abel
    Outpatient Department, National Health Centre, Budapest, Hungary
    Med Sci Monit 15:MS6-11. 2009
    ..The secondary goal of this investigation was to compare the safety and efficacy of combined ezetimibe / simvastatin treatment with simvastatin monotherapy...
  45. ncbi Glutathione S-transferase Alpha 1-1 and aminotransferases in umbilical cord blood
    M F Knapen
    Department of Obstetrics and Gynecology, University Hospital St Radboud, Nijmegen, Netherlands
    Early Hum Dev 54:129-35. 1999
    ..with that of the well known liver function markers alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in arterial and corresponding venous umbilical cord blood of 93 patients...
  46. ncbi Sleep deprivation affects speech
    Y Harrison
    Loughborough University, Leicestershire
    Sleep 20:871-7. 1997
    ..subjects underwent two counterbalanced 36-hour trials involving sleep deprivation (SD) and no sleep deprivation (NSD)...
  47. ncbi Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process
    Gregory L Willis
    The Bronowski Institute of Behavioural Neuroscience, Neurosciences Section, Coliban Medical Centre, Kyneton, Victoria, Australia
    Rev Neurosci 19:245-316. 2008
    For more than 50 years, Parkinson's disease (PD) has been conceptualized as a product of nigro-striatal dopamine (NSD) system degeneration...
  48. ncbi Bioavailability of astaxanthin stereoisomers from wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon in healthy men: a randomised, double-blind study
    Corinna E Rüfer
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Karlsruhe, Germany
    Br J Nutr 99:1048-54. 2008
    ..was to investigate the bioavailability and the configurational isomer distribution of the carotenoid astaxanthin (AST) in human plasma after ingestion of wild (Oncorhynchus spp.) and aquacultured (Salmo salar) salmon...
  49. ncbi Demonstration of antihistamine properties with AST-1: a bioactive extract from garden slugs (Diplosolenodes occidentalis)
    A Jacob
    Department of Basic Medical Sciences, The University of the West Indies, Kingston 7, Jamaica
    West Indian Med J 56:11-6. 2007 histamine from allergic sensitization, the authors investigated the effects of a semi-pure alcoholic extract (AST-1) on histamine-induced contraction of the guinea pig in vitro tracheal muscle preparation and cutaneous allergic ..
  50. pmc Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA
    Hun Kyu Ryeom
    Department of Radiology, Kyungpook National University School of Medicine, Taegu, Korea
    Korean J Radiol 5:231-9. 2004
    ..The purpose of this study is to develop a noninvasive method of quantitation of the hepatic function using Gd-EOB-DTPA through the deconvolution analysis...
  51. ncbi [The changes and significance of multiple organ functions in acute pancreatitis patients under hypoxic condition on plateau]
    Hai Hong Zhu
    Department of General Surgery, People s Hospital of Qinghai Province, Xining 810007, Qinghai, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:210-3. 2010
    ..To explore characteristics of the pathogenesis and progression of the acute pancreatitis (AP) in high altitude and the relationship between AP and plateau erythrocythemia...
  52. doi Frequency of inappropriate continuation of acid suppressive therapy after discharge in patients who began therapy in the surgical intensive care unit
    Catherine E Murphy
    Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont, USA
    Pharmacotherapy 28:968-76. 2008
    To determine the frequency with which patients who begin to receive stress ulcer prophylaxis in the surgical intensive care unit (SICU) are discharged receiving inappropriate acid suppressive therapy (AST).
  53. pmc Multiplex PCR method for detection of three Aeromonas enterotoxin genes
    Cesar I Bin Kingombe
    Microbiology Research Division, Bureau of Microbial Hazards, Food Directorate, Health Products and Food Branch, Sir Frederick G Banting Research Centre, Ottawa, Ontario, Canada
    Appl Environ Microbiol 76:425-33. 2010
    ..of specific primers was developed for the detection of the cytotoxic (act), heat-labile (alt), and heat-stable (ast) enterotoxin genes in Aeromonas spp...
  54. ncbi Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. A controlled short-term longitudinal study
    Giuseppe Perinetti
    Unit of Biochemistry, Department of Oral Sciences, Dental School, University G D Annunzio, Chieti, Italy
    J Periodontol 74:145-52. 2003
    ..This study used a longitudinal design to examine aspartate aminotransferase (AST) activity in gingival crevicular fluid (GCF) in order to assess whether AST in GCF has potential as a possible ..
  55. ncbi [Three cases with acute encephalopathy related with adenovirus type 7 infection]
    N Ohtsuki
    Department of Pediatrics, Urafune Hospital of Yokohama City University, School of Medicine
    No To Hattatsu 32:68-72. 2000
    ..Seizures in all the patients developed from 8 to 10 days after the onset of pyrexia. The values of serum AST, LDH and CRP elevated and those of WBC and serum protein decreased at the onset of encephalopathy...
  56. ncbi Diagnostic accuracy of plain radiographs and cineradiography in diagnosing traumatic scapholunate dissociation
    Jenny Pliefke
    Department of Hand Surgery, Replantation Surgery, and Microsurgery, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Germany
    Skeletal Radiol 37:139-45. 2008
    Missed tears of the scapholunate ligament (SLL) and scapholunate dissociation (SLD) after wrist injuries pose a high risk of post-traumatic osteoarthritis of the carpus...
  57. ncbi Inflation of antishock trousers increases bronchial response to methacholine in healthy subjects
    J Regnard
    Laboratoire de Physiologie, Faculté de Médecine Cochin Port Royal, Paris, France
    J Appl Physiol (1985) 68:1528-33. 1990
    ..changes in lung volumes and in bronchial response to methacholine chloride (MC) challenge when antishock trousers (AST) were inflated at venous occlusion pressure in healthy subjects in the standing posture, a maneuver known to shift ..
  58. ncbi Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression
    R J Oringer
    Department of Periodontics, State University of New York at Stony Brook, 11794 8703, USA
    J Periodontol 72:17-24. 2001
    Aspartate aminotransferase (AST), an enzyme released from necrotic cells, has been identified in gingival crevicular fluid (GCF), and elevated levels are associated with periodontal tissue destruction...
  59. doi [Evaluation of automated architect syphilis TP as a diagnostic laboratory screening test for syphilis]
    Jeeyong Kim
    Department of Laboratory Medicine, Korea University Hospital, Seoul, Korea
    Korean J Lab Med 28:475-82. 2008
    ..The aim of the study was to establish a new syphilis test algorithm using Architect Syphilis TP (Abbott Japan, Japan: AST), a fully automated treponemal antibody test, as a screening test in a university hospital laboratory...
  60. pmc Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide
    J R Curtis
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 510 20 Street South, FOT 840, Birmingham, AL 35294, USA
    Ann Rheum Dis 69:43-7. 2010
    ..RA) or psoriatic arthritis (PsA), the incidence of elevated alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes associated with methotrexate (MTX), leflunomide (LEF) and MTX+LEF versus other DMARDs was examined.
  61. ncbi Spontaneous radiation-induced rib fractures in breast cancer patients treated with postmastectomy irradiation. A clinical radiobiological analysis of the influence of fraction size and dose-response relationships on late bone damage
    M Overgaard
    Department of Oncology and Radiotherapy, Radiumstationen, Aarhus, Denmark
    Acta Oncol 27:117-22. 1988
    ..6%) even though they had been treated with the aim to obtain equivalent biologic response according to the NSD formula...
  62. ncbi [Clinical studies on 35 patients with infection-related acute encephalopathy]
    S Kimura
    Department of Pediatrics, Urafune Hospital of Yokohama City University School of Medicine
    No To Hattatsu 30:244-9. 1998
    ..Serum AST were elevated in 7.7 and 6 cases in (3), (4) and (5), respectively...
  63. ncbi Comparison between fractionated high dose rate irradiation and continuous low dose rate irradiation in spheroids
    M Omura
    Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan
    Acta Oncol 37:681-6. 1998
    ..was independent of the fraction size of HDR irradiation administrated, and the repair of sublethal damage (SLD) was absent, suggesting that the sparing effect of fractionated HDR irradiations was absent in spheroids...
  64. ncbi Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats
    Muhammed Yayla
    Eur J Pharmacol 726:87-95. 2014
    ..VII: received 140 mg/kg NAC (2 doses). According to biochemical results, TNF-α, ALT and AST levels were statistically increased in the paracetamol group, these parameters were improved in the bosentan groups...
  65. pmc Serum aminotransferase levels in healthy population from western India
    Satish Kumar
    Department of Pathology, BYL Nair Ch Hospital and TN Medical College, Mumbai, India
    Indian J Med Res 138:894-9. 2013
    ..Currently upper limits of normal for aspartate aminotransferase (AST) or ALT levels used are based on the western literature...
  66. doi Altered gastric vagal mechanosensitivity in diet-induced obesity persists on return to normal chow and is accompanied by increased food intake
    S J Kentish
    Nerve Gut Research Laboratory, Hanson Institute, Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia
    Int J Obes (Lond) 38:636-42. 2014
    ..We sought to determine whether changes in vagal afferent function and response to leptin in obesity were reversible by returning obese mice consuming a HFD to standard laboratory chow diet (SLD).
  67. ncbi Angiostatin II is the predominant glycoform in pleural effusates of rabbit VX-2 lung tumors
    Mark W C Hatton
    Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    J Lab Clin Med 139:316-23. 2002
    Angiostatin (AST), a polypeptide with potent antiangiogenic properties, is released proteolytically from plasminogen in vivo. Plasminogen exists naturally in plasma as two glycoforms (PLGs), I and II...
  68. pmc nsd, a locus that affects the Myxococcus xanthus cellular response to nutrient concentration
    Margaret Brenner
    Section of Microbiology and Center for Genetics and Development, The University of California, Davis, Davis, California 95616, USA
    J Bacteriol 186:3461-71. 2004
    ..Our analysis shows that the gene fusion is located in an open reading frame that we have designated nsd (nutrient sensing/utilizing defective) and that its expression is driven by a sigma70-like promoter...
  69. ncbi Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line
    Francesca Carubbi
    Dipartimento di Medicina Interna, Universita degli Studi di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Biochim Biophys Acta 1580:31-9. 2002
    ..Culture media, harvested at the end of each incubation period, were analyzed to evaluate aspartate transaminase (AST), alanine transaminase and gamma-glutamyltranspeptidase release...
  70. ncbi Allatostatin-like immunoreactivity in the abdomen of the locust Schistocerca gregaria
    Petra Skiebe
    Institut fur Biologie, Fachbereich Biologie, Chemie, Pharmazie, Neurobiologie, Freie Universitat Berlin, Königin Luise Strasse 28 30, 14195 Berlin, Germany
    Cell Tissue Res 325:163-74. 2006
    A polyclonal antibody against allatostatin 1 (AST-1) of cockroach Diploptera punctata was used to investigate the distribution of AST-like immunoreactivity within the abdomen of the locust, Schistocerca gregaria...
  71. ncbi Normal coordinate structural decomposition of the heme distortions of hemoglobin in various quaternary states and bound to allosteric effectors
    Monique Laberge
    Institute of Biophysics and Radiation Biology, Semmelweis University, Puskin u 9, Budapest H 1088, Hungary
    Mol Divers 7:15-23. 2003
    ..was investigated by subjecting CHARMM energy-minimized models to normal coordinate structural decomposition (NSD) analysis...
  72. ncbi Quantification and visualization of Dippu-AST mRNA in the brain of adult Diploptera punctata: mated females vs. virgin females vs. males
    Chris S Garside
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Insect Physiol 49:285-91. 2003
    ..We have investigated the levels of AST expression in the brain of adult mated and virgin females, and adult males of the cockroach Diploptera punctata, ..
  73. ncbi Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats
    Noriyoshi Kobayashi
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Nephron 91:480-5. 2002
    The aim of the present study was to determine if treatment with an oral adsorbent (AST-120, Kremezin) might decrease the urinary albumin excretion and serum indoxyl sulfate (s-IS), and prevent glomerular sclerosis in early-stage renal ..
  74. doi Mitigation of gamma-radiation induced abasic sites in genomic DNA by dietary nicotinamide supplementation: metabolic up-regulation of NAD(+) biosynthesis
    Vipen Batra
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India Electronic address
    Mutat Res 749:28-38. 2013
    ..underlying mechanism(s), male Swiss mice were maintained on control diet (CD) and nicotinamide supplemented diet (NSD)...
  75. ncbi Ameliorating effect of phytoestrogens on CCl4-induced oxidative stress in the livers of male Wistar rats
    Ritu Aneja
    Department of Chemistry, University of Delhi, Delhi, India
    Artif Cells Blood Substit Immobil Biotechnol 33:201-13. 2005
    ..tetrachloride (CCl4) induced changes in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione S transferase (GSH) and levels of glutathione (GSH) and thiobarbituric acid reactive substances (..
  76. ncbi [Secular increase in the incidence rate of drug-induced hepatitis due to anti-tuberculosis chemotherapy including isoniazid and rifampicin]
    Naohiro Nagayama
    Department of Respiratory Medicine, Tokyo National Hospital, 3 1 1, Takeoka, Kiyose shi, Tokyo 204 8585, Japan
    Kekkaku 78:339-46. 2003
    ..The criteria for selection of the patients were as follows. 1. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured before, and one month (20-40 days) and 2 months (45-75 days) ..
  77. ncbi Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon
    Randal A Wolff
    William S Middleton Memorial Veterans Hospital and University of Wisconsin Medical School, Madison, Wisconsin 53792 3236, USA
    J Vasc Surg 43:1028-36. 2006
    ..Transforming growth factor beta-1 (TGF-beta1) is a pleiotropic cytokine known to have powerful effects on cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis...
  78. ncbi Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study
    Timothy W Synold
    City of Hope Comprehensive Cancer Center, Duarte, California, USA
    Clin Cancer Res 13:3660-6. 2007
    ..To determine the toxicities, pharmacokinetics, and maximally tolerated doses of oxaliplatin in patients with hepatic impairment and to develop formal guidelines for oxaliplatin dosing in this patient population...
  79. pmc Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors
    Kabirullah Lutfy
    Division of Endocrinology, Molecular Medicine and Metabolism, Department of Internal Medicine, Charles R Drew University of Medicine and Sciences David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurochem 120:1108-16. 2012
    ..We used the CRH-R1-specific antagonist, antalarmin (ANT), the CRH-R1 and CRH-R2 peptide antagonist, astressin (AST), and the CRH-R2-specific peptide antagonist, astressin2b (AST2b), to determine which CRH receptor is involved in ..
  80. pmc The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay
    Biswadip Das
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 288:14742-55. 2013
    The autosomal recessive mutation, sld, attenuates mucous cell expression in murine sublingual glands with corresponding effects on mucin 19 (Muc19)...
  81. ncbi Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis
    D P Ringer
    Biochemical Pharmacology Section, Samuel Roberts Noble Foundation, Inc, Ardmore, Oklahoma
    Mol Carcinog 9:2-9. 1994
    ..basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis...
  82. doi Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease
    Shunsuke Ito
    Department of International Health Development, Tokyo Medical and Dental University, Tokyo, Japan
    J Leukoc Biol 93:837-45. 2013
    ..An oral adsorbent, AST-120, retards renal function deterioration by lowering IS, which is known to accumulate in CKD patients...
  83. doi Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency)
    Ken H Darzy
    Department of Endocrinology, Christie Hospital, Manchester, UK
    Clin Endocrinol (Oxf) 70:287-93. 2009
    ..reserve as indicated by substantially reduced group GH responses to the GHRH + arginine stimulation test (AST)...
  84. ncbi Comparative study of C-reactive protein and other biochemical parameters in patients with hepatitis B and malaria in Calabar, Nigeria
    U K Amah
    Department of Chemical Pathology, College of Medicine, Nnamdi Azikiwe University, Nnewi Campus
    Niger J Physiol Sci 26:109-12. 2011
    Serum levels of C-reactive proteins (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin and globulins were investigated using high sensitivity immunoturbidometric and colorimetric techniques in ..
  85. pmc Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
    Shingo Hatakeyama
    Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu chou, Hirosaki 036 8562, Japan
    Int J Nephrol 2012:376128. 2012
    The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis...
  86. doi Validation of three non-invasive markers in assessing the severity of liver fibrosis in chronic hepatitis C
    Samiullah Shaikh
    Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad
    J Coll Physicians Surg Pak 19:478-82. 2009
    To compare various biochemical markers i.e. APRI (AST to platelet ratio index), aspartate aminotransferase (AST) alanine aminotransferase (ALT) ratio, FIB-4 (AST, platelet, AST and age) with biopsy for assessing the severity of hepatic ..
  87. ncbi [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats]
    Yan Ding
    Department of Gastroenterology and Hepatology, Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China
    Zhonghua Yi Xue Za Zhi 89:699-703. 2009
    ..To investigate the therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof...
  88. doi Pediatric FAST and elevated liver transaminases: An effective screening tool in blunt abdominal trauma
    Juan E Sola
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Florida, USA
    J Surg Res 157:103-7. 2009
    ..We sought to determine if the focused assessment with sonography for trauma (FAST) combined with elevated liver transaminases (AST/ALT) could be used as a screening tool for intra-abdominal injury (IAI) in pediatric patients with BAT.
  89. doi Effects of bone and mineral metabolism on arterial elasticity in chronic renal failure
    Eva Kis
    First Department of Pediatrics, Semmelweis University, Budapest Bókay János u 53 54, 1083, Hungary
    Pediatr Nephrol 24:2413-20. 2009
    Arterial stiffness (Ast) individually predicts cardiovascular (CV) mortality. Ast increases via vascular calcification and can be characterized by pulse wave velocity (PWV)...
  90. pmc Free sialic acid storage disease without sialuria
    Fanny Mochel
    Institut National de la Sante et de la Recherche Médicale UMR S679, Hopital La Salpetriere, Paris, France
    Ann Neurol 65:753-7. 2009
    ..Both patients were homozygous for the K136E mutation in SLC17A5, the gene responsible for the free sialic acid storage diseases...
  91. doi Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Am J Gastroenterol 104:2182-8. 2009
    ..We tested the hypothesis that alcohol, alone and in combination with alcohol dehydrogenase (ADH) 1B and ADH1C genotypes, affects liver damage and disease in the general population...
  92. ncbi Decreased serum aminotransferase activity in patients with chronic renal failure: impact on the detection of viral hepatitis
    F Fabrizi
    Division of Nephrology and Dialysis, Institute of Hygiene and Preventive Medicine, Maggiore Hospital, Milano, Italy
    Am J Kidney Dis 38:1009-15. 2001
    ..Aspartate (AST) and alanine aminotransferase (ALT) activity was greater in antibody to hepatitis C (anti-HCV)-positive than anti-..
  93. ncbi Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis
    C Fu
    Department of Biochemistry, Vanderbilt University, 23rd at Pierce, Nashville, TN 37232, USA
    Clin Cancer Res 7:4182-94. 2001
    ..These results and the immunohistochemistry data suggest a therapeutic potential for the CM101 target protein HP59 both as a drug target and as a vaccine against pathoangiogenesis...
  94. doi Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress
    Hideki Fujii
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Nephrol Dial Transplant 24:2089-95. 2009
    ..Increased oxidative stress plays a role in the pathogenesis of CVD in CKD patients. The oral charcoal adsorbent AST-120 attenuates the progression of CKD possibly by removing uraemic toxins such as indoxyl sulfate (IS), and reduces ..
  95. doi Prevalence and long-term course of macro-aspartate aminotransferase in children
    Maria Caropreso
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    J Pediatr 154:744-8. 2009
    To investigate the prevalence, association with clinical conditions, and long-term course of macro-aspartate aminotransferase (macro-AST).
  96. ncbi Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 84:2664-72. 1999
    ..systolic and diastolic media-media distances, blood systolic (SPV) and diastolic (DPV) peak velocity, systolic (SLD) and diastolic (DLD) lumen diameter, and distensibility coefficient (DC) were measured at both common carotid ..
  97. pmc Sialic acid storage diseases. A multiple lysosomal transport defect for acidic monosaccharides
    G M Mancini
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    J Clin Invest 87:1329-35. 1991
    ..This study reports the first observation of a human lysosomal transport defect for multiple physiological compounds...
  98. doi Creatine phosphokinase and aspartate aminotransverase profiles and its relation to the severity of uterine torsion in Egyptian buffalo
    S M Amin
    Department of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, El Zeraa Str 114, 44519 Zagazig, Egypt
    Anim Reprod Sci 123:163-8. 2011
    ..the relationship between the serum concentrations of creatine phosphokinase (CPK), aspartate aminotransverase (AST) and the severity of uterine torsion...
  99. doi The effect of assisted and resisted sprint training on acceleration and velocity in Division IA female soccer athletes
    David E Upton
    Exercise Physiology Laboratory, Department of Kinesiology, Texas Christian University, Fort Worth, Texas, USA
    J Strength Cond Res 25:2645-52. 2011
    ..effects of a 4-week, 12-session training program using resisted sprint training (RST), assisted sprint training (AST), and traditional sprint training (TST) on maximal velocity and acceleration in National Collegiate Athletic ..
  100. doi Hepatic blood flow plays an important role in ischemia-reperfusion injury
    Dympna M Kelly
    Department of General Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 17:1448-56. 2011
    ..IR injury was defined by the aspartate aminotransferase (AST) level on postoperative day (POD) 2, and the patients were divided into 3 groups: (1) mild IR injury [AST < 500 ..
  101. pmc Prenatal screening of sialic acid storage disease and confirmation in cultured fibroblasts by LC-MS/MS
    Jeroen van den Bosch
    Department Clinical Genetics, Erasmus Medical Center, Dr Molewaterplein 50, 3015GE, Rotterdam, The Netherlands
    J Inherit Metab Dis 34:1069-73. 2011
    b>Sialic acid storage disease (SASD) is an inborn error resulting from defects in the lysosomal membrane protein sialin...

Research Grants47

  1. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..infiltration, 3- nitrotyrosine (3-NT), nitrite/nitrate, and poly(ADP-ribose) formation, BUN, creatinine, NGAL, AST, ALT, histology injury score, and serum concentrations of TNF-1, HMGB-1, IL-6, TRP14, Trx1, LC8, I:B1, IL-12, MIP-..
  2. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..Plasma AST and ALT levels will be used to monitor liver function while histology will be used to monitor the effects of the ..
  3. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..Enzymatic assays of serum ALT and AST, widely used as part of a `hepatic function'panel, are neither sensitive nor particularity specific to the ..
  4. Novel Small-molecule TNF-a Modulators as Chemoprotective Agents
    Jiajiu Shaw; Fiscal Year: 2012
    ..I study, UTL-5g has been shown to reduce levels of blood urea nitrogen (BUN), creatinine, aspartate transaminase (AST), and alanine transaminase (ALT) elevated by cisplatin, indicating the protection of kidney and liver by UTL-5g...
    Joann A Boughman; Fiscal Year: 2011
    ..Signature;completed on submission to *Name: Prefix [unreadable] First Name Middle Name 'l-ast Name Suffix Boughman TItie: Executive Vice President Telephone No...
  6. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..membrane/cytosolic enzyme, can be considered an early sign of hepatic injury, preceding even the increase of ALT or AST in blood...
  7. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..However, they increase plasma aminotransferases, such as ALT and AST, indicating liver injury...
  8. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Hepatocellular injury and function will be determined with plasma levels of ALT, AST, platelets, albumin, hyaluronic acid and total and conjugated bilirubin...
    Raj M Lakshman; Fiscal Year: 2013
    ..Effects of omega3FA and SP on Chronic Ethanol-induced Increases in Plasma and Hepatic Lipids and Lipoproteins, AST, ALT and Their Correlation with Liver Histopathology. Specific Aim 2...
  10. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..The mechanisms of scleroderma lung disease (SLD) are not well understood, and the efficiency of available therapies is limited...
    Robert M Elashoff; Fiscal Year: 2012
    ..morbidity and mortality, so that studies focused on the development of new treatments for scleroderma lung disease (SLD) have the potential to make a significant impact on the lives of scleroderma patients...
  12. Impact of adipokines and insulin resistance on progression of prehypertension
    Cynthia Cheng; Fiscal Year: 2013
    ..x 2 visits), we will assess obesity (body mass index, BMI, waist circumference, WC, abdominal skinfold thickness, AST), adipokine levels (IL-6, TNF1, PAI-1, adiponectin), CRP, microvascular function, office blood pressure (SBP office)..
  13. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..The sublaterodorsal nucleus (SLD), in the brainstem, is a REM sleep induction zone where the local application of GABAA receptor antagonists can ..
  14. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..RAST addresses the major limitations of standard phenotypic AST platforms (e.g., bioMerieux Vitek, BD Phoenix) by providing rapid (90 minutes vs. 2 days) and decentralized (POC vs...
  15. Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening. Phase
    Kevin M Patrie; Fiscal Year: 2013
    ..another. For example, the level of aminotransferases (ALT and AST) in blood is a widely accepted practice for detecting liver damage...
  16. The accessory Sec system of Gram-positive pathogens
    Paul M Sullam; Fiscal Year: 2013
    ..Although both the extended N region of the GspB signal peptide and the novel AST domain (amino acids 91 - 117) of GspB are essential for export, it is unknown how these regions facilitate this ..
  17. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank A Middleton; Fiscal Year: 2010
    ..In the same animals, we will also assess potential liver or cardiac damage by monitoring serum ALT and AST levels...
  18. Development of a novel small molecule, UTL-5g, to treat oxaliplatin-induced throm
    Jiajiu Shaw; Fiscal Year: 2013
    ..We will also monitor the injuries on liver and kidney by analyzing AST, ALT, BUN, and creatine...
  19. Intra Cavitary Pharmacokinetics and Drug Resistance in Pulmonary Tuberculosis
    RUSSELL RYAN KEMPKER; Fiscal Year: 2013
    ..Recent reports highlight the substantial risk of development of additional drug resistance during SLD treatment...
  20. Gene Therapy and Radiation Therapy for Prostate Cancer
    Svend O Freytag; Fiscal Year: 2013
    ..therapy can be combined safely with intensity modulated radiation therapy (IMRT) and androgen suppression therapy (AST) in men with newly-diagnosed, high-risk prostate cancer...
  21. Development of anti-human TL1A monoclonal antibody for the treatment of human ast
    Vadim V Deyev; Fiscal Year: 2010
  22. Mechanism and targets of non-stop decay in eukaryotic translation
    KRISTIN SMITH-KOUTMOU; Fiscal Year: 2013 the elimination of defective mRNAs;non-sense mediated decay (NMD), no-go decay (NGD), and non-stop decay (NSD)...
  23. Pontine Control of REM Atonia
    Elda Arrigoni; Fiscal Year: 2013
    ..Considerable evidence demonstrates that neurons of the sublaterodorsal (SLD) nucleus of the pons, also known as the subcoreuleus, generate muscle atonia during REM sleep...
  24. Exposure to Pesticides: A Fetal Environmental Risk Factor for Parkinson's Disease
    BRIAN BARLOW; Fiscal Year: 2010 motor dysfunction and pathologically by depletion of dopamine (DA)-producing neurons in the nigrostriatal DA (NSD) system...
  25. Neurobiological Mechanisms of Antidepressant Effects
    David A Morilak; Fiscal Year: 2013
    ..risk factor for depression, and we have shown previously that performance on an attentional set-shifting test (AST), which is a measure of prefrontal-dependent cognitive flexibility in rats, is compromised by chronic stress...
  26. Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
    JOHN JOSEPH MEKALANOS; Fiscal Year: 2010
    ..We will apply a new method we developed called AST to monitor and study the nature of "conditionally viable environmental cells (CVEC)" of pathogenic V...
  27. Regulation of the Fanconi Anemia Pathway by Ubiquitination
    ALAN D D'ANDREA; Fiscal Year: 2013
    ..test the hypothesis that the USP1/UAF1 deubiquitinating complex is targeted to its FANCD2/FANCI substrate through a SLD (Sumo-Like Domain)/SIM interaction. 2) To examine the functional interaction between FANCD2/FANCI and PCNA...
  28. Dopamine Dysfunction in Schizophrenia
    Anissa Abi-Dargham; Fiscal Year: 2013
    ..from Center investigators: 1) the striatal DAergic excess in schizophrenia is greatest in the associative striatum (AST), 2) the AST receives convergent input from dorsolateral-prefrontal cortex (DLPFC), the anterior cingulate cortex (..
  29. Proteomic Markers of Alcohol Abuse (Phase 1)
    LAWRENCE SNELL; Fiscal Year: 2009
    ..methodology (ProteoSep TM) to accurately measure currently used state markers for excessive alcohol ingestion (GGT, AST and CDT) in plasma and serum samples and develop a measurement, with ProteoSep TM technology, of MAO-B protein in ..
  30. Neural pathway of REM sleep atonia
    Jun Lu; Fiscal Year: 2013
    ..We have previously identified that the glutamatergic neurons in the sublaterodorsal tegmental nucleus (SLD) project to the spinal cord inhibitory interneurons, which proposed to suppress the motor activity during REM sleep...
  31. Coping with Adolescent Peer Victimization and Reducing Anxious/Depressed Symptoms
    Annette M La Greca; Fiscal Year: 2013
    ..and adapting an evidence-based intervention for depression, Interpersonal Psychotherapy for Adolescents (IPT-AST), that focuses on improving interpersonal skills and managing conflict...
  32. An Assessment of Liver Disease in HIV-infected and HIV/HBV Co-infected Tanzanians
    Claudia A Hawkins; Fiscal Year: 2013
    ..will be assessed using two non-invasive serum markers of liver fibrosis and cirrhosis, aspartate aminotransferase (AST)-to-platelet ratio index (APRI) and Fib-4...
  33. Alternative mechanisms of different stages in eukaryotic translation
    ANDREY PISAREV; Fiscal Year: 2013
    ..No-Go Decay (NGD) and Non-Stop Decay (NSD) are essential cellular mRNA quality control pathways in eukaryotes aiming to detect stalled translation elongation ..
  34. 2/2 Bending adolescent depression trajectories through personalized prevention
    Benjamin L Hankin; Fiscal Year: 2013
    ..with Stress (CWS), a cognitive behavioral program, and Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an interpersonal program...
  35. A Kit for Rapid AST of Mycobacterium tuberculosis from Clinical Samples
    MATTHEW CHARLES MULVEY; Fiscal Year: 2013
    ..Aim II. Development of a kit for standardized and reproducible front-line antibiotic susceptibility testing (AST) of clinical samples. Aim III. Clinial Evaluation of the SGM-phage kit for TB AST directly from patient samples...
  36. 1/2 Bending Adolescent Depression Trajectories Through Personalized Prevention
    Jami F Young; Fiscal Year: 2013
    ..with Stress (CWS), a cognitive behavioral program, and Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an interpersonal program...
  37. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..For safety, we will follow hemoglobin/hematocrit, sleep apnea scores, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and prostate examinations...
  38. Rapid, Cost-Effective Nucleic Acid Testing for Active Surveillance and Molecular
    BEN HINDSON; Fiscal Year: 2011
    ..MRSA infections that requires the detection of the MRSA-colonized patient through active surveillance testing (AST)...
  39. Development of Small-Molecule Probes of the Histone Methyltransferase NSD2
    Alykhan Shamji; Fiscal Year: 2013
    ..The NSD histone methyltransferases, which are selective for histone H3 lysine 36 (H3K36) are frequently altered in various ..
    Emerich Fiala; Fiscal Year: 2000
    ..of 2-NP to a species capable of aminating guanine residues at C8 is mediated through aryl sulfotransferase (AST), probably isozyme IV...
    Joel Bedford; Fiscal Year: 1993
    ..caffeine treatments would also be undertaken with emphasis on the relationship of the effects observed to PLD and SLD "repair"...
  42. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..The techniques we will use to accomplish this are fMRI (BOLD and AST based), electrophysiology, fluorescence quenching, laser Doppler and near-infrared spectroscopy at high spatial and ..
    Shalender Bhasin; Fiscal Year: 2005
    ..For safety, we will follow hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, digital rectal examinations, and sleep ..
  44. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..For safety, we will follow hemoglobin/hematocrit, AST and ALT, PSA, plasma lipids, apolipoproteins, and lipoprotein particles, and insulin sensitivity by the modified ..
  45. A nanoparticle prognosticator of chemotherapy outcomes
    Russell Lebovitz; Fiscal Year: 2009
    ..discovery it was shown that NCTX can predict the outcome of chemotherapy using Stealth Liposomal Doxorubicin (SLD). NCTX consists of a clinically used Iodinated contrast agent encapsulated in a Pegylated liposome...
  46. Association between ANP and NPRA Gene Polymorphisms and Severity of Atopy and Ast
    Shyam Mohapatra; Fiscal Year: 2009
    ..Establishing an association of ANP polymorphisms will not only confirm the importance of this gene in asthma, but may also indicate who will benefit from an ANP-based therapy. ..
  47. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..and hyperleptinemia, and elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). 3...