SLBP

Summary

Gene Symbol: SLBP
Description: stem-loop binding protein
Alias: HBP, histone RNA hairpin-binding protein, hairpin binding protein, histone, histone binding protein, histone stem-loop binding protein, stem-loop (histone) binding protein
Species: human

Top Publications

  1. ncbi The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing
    Z F Wang
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill 27599, USA
    Genes Dev 10:3028-40. 1996
  2. pmc Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA
    Z Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 19:3561-70. 1999
  3. pmc Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms
    M L Whitfield
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 20:4188-98. 2000
  4. pmc A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 16:58-71. 2002
  5. ncbi A 3' exonuclease that specifically interacts with the 3' end of histone mRNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell 12:295-305. 2003
  6. ncbi The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells
    Xiujie Zhao
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    J Cell Sci 117:6043-51. 2004
  7. ncbi Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
    Handan Kaygun
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Struct Mol Biol 12:794-800. 2005
  8. ncbi NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs
    Takashi Narita
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Kanagawa 226 8501, Japan
    Mol Cell 26:349-65. 2007
  9. pmc SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein
    Nihal G Cakmakci
    Program in Molecular Biology and Biotechnology, CB 7100, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 28:1182-94. 2008
  10. pmc Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'
    Thomas E Mullen
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 22:50-65. 2008

Research Grants

  1. ELIZABETH ANN SCHLENK; Fiscal Year: 2014
  2. Non-Modulation Phenotype and Vascular Dysfunction in Diabetes Mellitus
    Gordon H Williams; Fiscal Year: 2010
  3. Text Messaging to Improve Hypertension Medication Adherence in African Americans
    NANCY TRYGAR ARTINIAN; Fiscal Year: 2011
  4. JARROD W BARNES; Fiscal Year: 2016
  5. Understanding Disparities in Obesity and its Comorbidities in the US
    Youfa Wang; Fiscal Year: 2010
  6. Zhiyong Zhao; Fiscal Year: 2016
  7. Development of RIP-Chip methods and tiled arrays to identify functional elements
    Michael L Whitfield; Fiscal Year: 2010
  8. HEXOSAMINES, GLUCOSE TOXICITY AND INSULIN RESISTANCE
    Donald A McClain; Fiscal Year: 2013
  9. Danesh Moazed; Fiscal Year: 2014
  10. Samuel Waxman; Fiscal Year: 2015

Detail Information

Publications237 found, 100 shown here

  1. ncbi The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing
    Z F Wang
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill 27599, USA
    Genes Dev 10:3028-40. 1996
    ..The stem-loop binding protein (SLBP) that binds the 3' end of histone mRNA is a candidate for the factor that participates in most, if not all, of the ..
  2. pmc Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA
    Z Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 19:3561-70. 1999
    ..The cleavage reaction requires at least two trans-acting factors: the stem-loop binding protein (SLBP), which binds the stem-loop sequence, and the U7 snRNP that interacts with a sequence downstream from the cleavage ..
  3. pmc Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms
    M L Whitfield
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 20:4188-98. 2000
    ..A 31-kDa stem-loop binding protein (SLBP) binds the 3' end of histone mRNA...
  4. pmc A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 16:58-71. 2002
    The stem-loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3'-end processing by promoting stable association of U7 snRNP with the pre-mRNA...
  5. ncbi A 3' exonuclease that specifically interacts with the 3' end of histone mRNA
    Zbigniew Dominski
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell 12:295-305. 2003
    ..Previous studies have suggested that the stem-loop binding protein (SLBP) is the only protein binding this region...
  6. ncbi The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells
    Xiujie Zhao
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    J Cell Sci 117:6043-51. 2004
    ..In metazoans, the histone RNA binding protein HBP/SLBP is involved in post-transcriptional control of histone gene expression...
  7. ncbi Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
    Handan Kaygun
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Struct Mol Biol 12:794-800. 2005
    ..Here we show that regulated degradation of histone mRNAs requires Upf1, a key regulator of the nonsense-mediated decay pathway, and ATR, a key regulator of the DNA damage checkpoint pathway activated during replication stress...
  8. ncbi NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs
    Takashi Narita
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama, Kanagawa 226 8501, Japan
    Mol Cell 26:349-65. 2007
    ..of replication-dependent histone mRNAs, most likely through association with the histone stem-loop binding protein (SLBP). Strikingly, absence of NELF and CBC causes aberrant production of polyadenylated histone mRNAs...
  9. pmc SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein
    Nihal G Cakmakci
    Program in Molecular Biology and Biotechnology, CB 7100, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 28:1182-94. 2008
    ..The 3' end of histone mRNA is required for histone mRNA translation, as is the stem-loop binding protein (SLBP), which binds the 3' end of histone mRNA...
  10. pmc Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'
    Thomas E Mullen
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 22:50-65. 2008
    ..Degradation of histone mRNAs requires the stem-loop sequence, which binds the stem-loop-binding protein (SLBP), active translation of the histone mRNA, and the location of the stem-loop close to the termination codon...
  11. pmc The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein
    F Martin
    Abteilung für Entwicklungsbiologie, Zoologisches Institut der Universität Bern, Switzerland
    EMBO J 16:769-78. 1997
    ..These features prompted us to select for HBP-encoding human cDNAs by RNA-mediated three-hybrid selection in Saccharomyces cerevesiae...
  12. pmc Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase
    Lianxing Zheng
    Department of Biochemistry and Biophysics Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:1590-601. 2003
    ..The protein that binds the 3' end of histone mRNA, stem-loop binding protein (SLBP), is required for histone pre-mRNA processing and is involved in multiple aspects of histone mRNA metabolism...
  13. ncbi Expression of an RNAi-resistant SLBP restores proper S-phase progression
    E J Wagner
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC 27599, USA
    Biochem Soc Trans 33:471-3. 2005
    ..are unique in that they lack a 3'-polyadenylated tail, but instead end in a conserved stem loop that is bound by SLBP (stem-loop binding protein). SLBP is required for efficient histone mRNA synthesis and translation...
  14. ncbi [Arterial hypertension and socioeconomic status in a representative population of French railway drivers]
    J P Cambou

    Arch Mal Coeur Vaiss 91:989-93. 1998
    ..b>HBP corresponds to systolic blood pressure (BP) 160 mmHg or diastolic BP > or = 95 mmHg or to normal BP under ..
  15. ncbi Home blood pressure normalcy: the Didima study
    G S Stergiou
    Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
    Am J Hypertens 13:678-85. 2000
    To evaluate reference values of home blood pressure (HBP) a cross-sectional community study was conducted on 694 adult subjects (aged > or = 18 years) of the village Didima in southern Greece (participation rate 76.4%)...
  16. pmc Transcriptional regulation of the heme binding protein gene family of Bartonella quintana is accomplished by a novel promoter element and iron response regulator
    James M Battisti
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA
    Infect Immun 75:4373-85. 2007
    We previously identified a five-member family of hemin-binding proteins (Hbp's) of Bartonella quintana that bind hemin on the outer surface but share no homology with known bacterial heme receptors...
  17. doi Can validated wrist devices with position sensors replace arm devices for self-home blood pressure monitoring? A randomized crossover trial using ambulatory monitoring as reference
    George S Stergiou
    Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
    Am J Hypertens 21:753-8. 2008
    ..pressure (BP) at the arm level are regarded as more accurate than wrist devices and are preferred for home BP (HBP) monitoring...
  18. ncbi [Is scheduled hospitalization over a specific period still justified in hypertension?]
    C Mounier-Vehier
    Service de Medecine Interne et Hypertension Arterielle, Hopital Cardiologique, CHRU de Lille
    Arch Mal Coeur Vaiss 86:1181-5. 1993
    ..3 mmHg). Figures of MBP superior to 105 mmHg confirmed permanent HBP (High Blood Pressure)...
  19. ncbi Home self-monitoring of blood pressure: is fully automated oscillometric technique as good as conventional stethoscopic technique?
    G S Stergiou
    Hypertension Centre, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
    Am J Hypertens 10:428-33. 1997
    Home blood pressure (HBP) measurement is becoming increasingly popular as an additional source of information for the practicing physician...
  20. pmc Structure, function, and evolution of biogenic amine-binding proteins in soft ticks
    Ben J Mans
    Laboratory for Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 283:18721-33. 2008
    ..binding site rather than the two sites previously described for the female-specific histamine-binding protein (FS-HBP), the histamine-binding lipocalin of the tick Rhipicephalus appendiculatus...
  21. ncbi [A familial history of hypertension is associated with the development of hypertension and nephroangiosclerosis in patients with glomerulonephritis caused by mesangial IgA deposits]
    R Boulahrouz
    , , Saint-Brieuc
    Arch Mal Coeur Vaiss 89:1065-8. 1996
    ..Renal vascular lesions, i.e. nephrosclerosis, often precede the onset of hypertension (HBP) in young patients with IgAN...
  22. ncbi Inducing a cell-mediated immune response against peptides of the Plasmodium vivax circumsporozoite protein
    B E Thomas
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Ann Trop Med Parasitol 95:573-86. 2001
    ..and the conserved region (region II) containing the hepatocyte-binding region extended to include a T-cell epitope (HBP). The study was conducted in outbred mice and two genetically unrelated inbred strains of mice...
  23. ncbi The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements
    Kyuzi Kamoi
    Department of Medicine, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
    Clin Exp Hypertens 27:369-76. 2005
    ..control of high blood pressure (BP) after awakening in the morning (morning hypertension) as determined by home BP (HBP), as well as BP control throughout the day, may prevent diabetic vascular complications...
  24. pmc A Legionella pneumophila gene that promotes hemin binding
    W A O'Connell
    Department of Microbiology Immunology, Northwestern University, Chicago, Illinois 60611, USA
    Infect Immun 64:842-8. 1996
    ..Subcloning and nucleotide sequence analysis determined that a single open reading frame, which was designated hbp for hemin-binding promotion, was responsible for this binding activity...
  25. doi Dimethyl sulfoxide (DMSO) as the sulfur source for the production of desulfurizing resting cells of Gordonia alkanivorans RIPI90A
    Ghasemali Mohebali
    Department of Petroleum Biotechnology, Biotechnology Research Center, Research Institute of Petroleum Industry, Tehran, Iran
    Microbiology 154:878-85. 2008
    ..DBT is impractical because of its high price, low water solubility, and growth inhibition by 2-hydroxybiphenyl (2-HBP), which is the end product of the 4S pathway...
  26. ncbi Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol
    S Iwahara
    Department of Pediatrics, Cornell University Medical College, New York, New York 10021, USA
    Biochemistry 34:13398-406. 1995
    ..an affinity (Kd = 55 nM) higher than that of the abundant cytosolic heme-binding proteins, heme-binding protein (HBP)/liver fatty acid-binding protein (L-FABP) and the glutathione S-transferases (GSTs) (Kd = 100-200 nM)...
  27. ncbi Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid
    Lalit P Singh
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cell Biochem Funct 25:537-50. 2007
    ..ECM) expression in renal mesangial cells is its metabolic flux through the hexosamine biosynthesis pathway (HBP)...
  28. pmc Modulation of lipopolysaccharide-induced monocyte activation by heparin-binding protein and fucoidan
    M Heinzelmann
    Department of Physiology and Biophysics, Department of Surgery, University of Louisville, School of Medicine, Louisville, Kentucky, USA
    Infect Immun 66:5842-7. 1998
    Activated polymorphonuclear leukocytes release heparin-binding protein (HBP; also known as CAP37 or azurocidin) from azurophilic granules...
  29. doi Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis
    Rachana Garg
    Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, India
    Toxicol Appl Pharmacol 232:428-39. 2008
    ..of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks...
  30. doi Reduction and suppression of methemoglobin loaded in the polymeric nanoparticles intended for blood substitutes
    Xiaolan Zhang
    Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    J Biomed Mater Res B Appl Biomater 87:354-63. 2008
    ..preparation, and a second sustaining postreduction, was developed to control the metHb in Hb-loaded nanoparticles (HbP) with porous microstructure to a desirable level...
  31. ncbi Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high-molecular-weight glycoprotein antigen common to the kidney and teratocarcinomas
    M Nakamoto
    Department of Biochemistry, Faculty of Medicine, Kagoshima University
    J Biochem 114:344-9. 1993
    Heparin binding protein-44 (HBP-44) is a heparin binding protein of 44 kDa, found by cDNA cloning using antibodies against teratocarcinoma glycoproteins [Furukawa, T. et al. (1990) J. Biochem. 108, 297-302]...
  32. ncbi Overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts enhances glucose-mediated glycogen accumulation via suppression of glycogen phosphorylase activity
    E D Crook
    Department of Medicine, University of Mississippi Medical Center, and Veterans Administration Medical Center, Jackson 39216, USA
    Endocrinology 141:1962-70. 2000
    The hexosamine biosynthesis pathway (HBP) mediates many of the adverse effects of excess glucose. We have shown previously that glucose down-regulates basal and insulin-stimulated glycogen synthase (GS) activity...
  33. ncbi Insulin sensitivity and cardiovascular risk factors in hypertensive and normotensive native Ghanaians
    A G B Amoah
    Diabetes Research Laboratory, Department of Medicine and Therapeutics, University of Ghana Medical School, Post Office Box 4236, Accra, Ghana
    Diabetologia 46:949-55. 2003
    ..The objective of this study was to examine the relationships among insulin and insulin sensitivity and risk factors for cardiovascular diseases in native Ghanaians with and without hypertension...
  34. ncbi Self-measurement of blood pressure in arterial hypertension--preliminary results from the AMPA study
    Joao Maldonado
    Instituto de Investigação e Formação Cardiovascular Penacova, Portugal
    Rev Port Cardiol 28:7-21. 2009
    ..The AMPA study is intended to contribute to this debate, exploring the potential usefulness of this methodology in the clinical setting of arterial hypertension using a prospective, observational and multicenter design...
  35. ncbi Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding
    J S Kastrup
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Proteins 42:442-51. 2001
    Heparin binding protein (HBP) is an inactive serine protease homologue with important implications in host defense during infections and inflammations...
  36. ncbi Transmissible Burkholderia cepacia genomovar IIIa strains bind and convert monomeric iron(III) protoporphyrin IX into the mu-oxo oligomeric form
    John W Smalley
    Clinical Dental Science, University of Liverpool, Liverpool L69 3GN
    Microbiology 149:843-53. 2003
    ..highly transmissible amongst patients with cystic fibrosis (CF) and express a 97 kDa putative haem-binding protein (HBP) [Smalley, J. W., Charalabous, P., Birss, A. J. & Hart, C. A. (2001). Clin Diagn Lab Immunol 8, 509-514]...
  37. ncbi Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine
    Tamas Nagy
    Dept of Cell Biology, Univ of Alabama at Birmingham, 1530 Third Ave South, 684 MCLM Bldg, Birmingham, AL 35294 0005, USA
    Am J Physiol Cell Physiol 290:C57-65. 2006
    ..This appears to be related to an increase in flux through the hexosamine biosynthesis pathway (HBP) and decreased Ca2+ entry into the cells; however, a direct link between HBP and intracellular Ca2+ homeostasis has ..
  38. doi Histamine bronchoprovocation does not affect bronchoalveolar lavage fluid cytology, gene expression and protein concentrations of IL-4, IL-8 and IFN-gamma
    G A Perkins
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States
    Vet Immunol Immunopathol 126:230-5. 2008
    In diagnosing inflammatory airway disease (IAD) in performance horses, a histamine bronchoprovocation (HBP) test is often performed...
  39. ncbi [Sleep and hypertension. An epidemiologic study in 7,901 workers]
    F Houyez
    , , Paris
    Arch Mal Coeur Vaiss 83:1085-8. 1990
    ..Among them, 6,551 (86.9%) did not suffer from high blood pressure (HBP) (blood pressure less than 160/95 mmHg), 618 (8.2%) presented a high blood pressure but were not treated, 371 (4...
  40. ncbi Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins
    N Yao
    Department of Biochemistry, Howard Hughes Medical Institute, Houston, Texas 77030
    Biochemistry 33:4769-79. 1994
    The structure of the histidine-binding protein (HBP, M(r) = 26,100), involved solely in active transport, has been determined by the molecular replacement technique and refined to 1.89-A resolution and to an R-factor of 0.199...
  41. ncbi High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E
    D S Chiu
    Division of Cardiology, University of Washington 98195 6422, USA
    Arterioscler Thromb Vasc Biol 17:2350-8. 1997
    ..by cellular cholesterol loading, including apolipoprotein E (apoE) and the recently cloned HDL-binding protein (HBP), but only apoE has been shown to be upregulated in cholesterol-loaded cells in atherosclerosis...
  42. ncbi Modulation of the humoral response to repeat and non-repeat sequences of the circumsporozoite protein of Plasmodium vivax using novel adjuvant and delivery systems
    B E Thomas
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Ann Trop Med Parasitol 95:451-72. 2001
    ..and a putative T-cell epitope extended from a conserved region (region II) containing a hepatocyte-binding region (HBP)...
  43. ncbi Assessment of drug effects on blood pressure and pulse pressure using clinic, home and ambulatory measurements
    G S Stergiou
    Hypertension Center, Third University Department of Medicine, Sotira Hospital, Athens, Greece
    J Hum Hypertens 16:729-35. 2002
    ..ARB) on blood pressure (BP) and pulse pressure (PP) measured in the clinic (CBP and CPP, respectively), at home (HBP, HPP) and with ambulatory monitoring (ABP, APP)...
  44. pmc Hexosamines, insulin resistance, and the complications of diabetes: current status
    Maria G Buse
    Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Endocrinol Metab 290:E1-E8. 2006
    The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of glycolysis...
  45. pmc Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels
    Jia Liu
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Cell Cardiol 42:177-85. 2007
    ..amidotransferase (GFAT) regulates the entry of glucose into the hexosamine biosynthesis pathway (HBP), and activation of this pathway has been shown to be cardioprotective...
  46. ncbi Effect of hypercortisolism control on high blood pressure in Cushing's syndrome
    Reynaldo M Gomez
    Division Endocrinologia, Hospital de Clinicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 67:439-44. 2007
    Many hypertensive patients affected by endogenous Cushing's syndrome (CS) persist with high blood pressure (HBP) despite good control of cortisol excess...
  47. doi Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake: the Ohasama study
    Michihiro Satoh
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan
    Hypertens Res 34:361-6. 2011
    ..We investigated the association between ARR and the prevalence of hypertension using home blood pressure (HBP) measurements in community residents stratified for long-term habitual dietary sodium intake...
  48. ncbi Bedtime versus at awakening administration of BP lowering drugs--is it the way to success?
    H Balan
    Carol Davila University of Medicine and Pharmacy, Bucharest Medical Clinic, Clinical Emergency Hospital, Ilfov County, Romania
    Rom J Intern Med 47:355-61. 2009
    The "manometric" way of considering the complex management of high blood pressure (HBP) must remain ancient history...
  49. ncbi Relation of neurocardiovascular instability to cognitive, emotional and functional domains
    C Bendini
    Department of Geriatrics, University of Modena and Reggio Emilia, Nuovo Ospedale Civile S Agostino Estense, Baggiovara, I 41100 Modena, Italy
    Arch Gerontol Geriatr 44:69-74. 2007
    ..suggest that LBP, neurocardiovascular instability, like the OH, and atherosclerosis resulting from long standing HBP, reduces cerebral blood flow, increasing the risk of cognitive impairment, morbidity and mortality...
  50. doi Salt and high blood pressure
    Sailesh Mohan
    Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Clin Sci (Lond) 117:1-11. 2009
    b>HBP (high blood pressure) is the leading risk of death in the world. Unfortunately around the world, blood pressure levels are predicted to become even higher, especially in developing countries...
  51. doi Outcomes in percutaneous stenting of non-hepato-biliary/pancreatic malignant jaundice
    M T Meller
    Department of Radiology, The James Cook University Hospital, Middlesbrough, UK
    Eur J Cancer Care (Engl) 19:664-8. 2010
    ..of percutaneous transhepatic placement of metallic biliary stents for non-hepato-biliary/pancreatic (non-HBP) malignant obstructive jaundice...
  52. ncbi Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase
    P Styczynski
    Department of Pharmacology, University of Iowa, Iowa City 52242
    Mol Pharmacol 40:80-4. 1991
    ..hepatic microsomal UDP-glucuronosyltransferase (UDPGT) that catalyzes the glucuronidation of 4-hydroxybiphenyl (4-HBP) has been purified to homogeneity...
  53. ncbi Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein
    A V Bocharov
    Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapy, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    Biochemistry 40:4407-16. 2001
    A new human 95 kDa high density lipoprotein (HDL)-binding protein (HBP) corresponding to a high affinity HDL-binding site with K(d) = 1.67 microg/mL and a capacity of 13.4 ng/mg was identified in human fetal hepatocytes...
  54. ncbi [Comparison and reproducibility of 4 methods of indirect blood pressure measurement in moderate hypertension]
    T Denolle
    Cabinet de Cardiologie, Dinard
    Arch Mal Coeur Vaiss 88:1165-70. 1995
    ..under similar study conditions: daily ambulatory recordings (ABP), home self-measurement readings (over 5 days) (HBP), 2-minute repeated automatic BP measurements during the 20 minutes preceding the physician examination (RABP) and ..
  55. doi Development of [(90)Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases
    Kazuma Ogawa
    Advanced Science Research Center, Kanazawa University, Kanazawa, Japan
    Nucl Med Biol 36:129-35. 2009
    ..By applying a similar concept, we hypothesized that a bone-specific directed (90)Y-labeled radiopharmaceutical could be developed...
  56. ncbi Morning blood pressure at home predicts erythropoietin-induced hypertension in patients with chronic renal diseases
    Satoru Kuriyama
    Division of Nephrology, Saiseikai Central Hospital, 1 4 17 Mita, Minato ku, Tokyo 108 0073, Japan
    Clin Exp Nephrol 11:66-70. 2007
    ..However, recent investigations suggest that BP measured at home (HBP) may be of more importance for clinical practice in hypertension...
  57. doi Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases
    Kazuma Ogawa
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi cho, Sakyo ku, Kyoto, 606 8501, Japan
    Eur J Nucl Med Mol Imaging 36:115-21. 2009
    We have developed a (186)Re-mercaptoacetylglycylglycylglycine complex-conjugated bisphosphonate ((186)Re-MAG3-HBP) for the treatment of painful bone metastases...
  58. doi Emergence of diplopia and oscillopsia due to Heimann-Bielschowsky phenomenon after cataract surgery
    S H Jeong
    Department of Neurology, College of Medicine, Seoul National University, Seoul National University Bundang Hospital, Gyeonggi Do, Korea
    Br J Ophthalmol 92:1402. 2008
    The Heimann-Bielschowsky phenomenon (HBP) refers to coarse vertical oscillation of the eye with impaired vision. The ocular movements are strictly monocular, occurring only in the eye with amblyopia...
  59. ncbi Continuous flow immunosensor for highly selective and real-time detection of sub-ppb levels of 2-hydroxybiphenyl by using surface plasmon resonance imaging
    K Vengatajalabathy Gobi
    Art, Science and Technology Center for Cooperative Research, Kyushu University, Kasuga shi, Fukuoka 816 8580, Japan
    Biosens Bioelectron 20:350-7. 2004
    A biosensor based on surface plasmon resonance (SPR) is developed for the detection of 2-hydroxybiphenyl (HBP)...
  60. ncbi Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells
    J Aaron Matthews
    Department of Chemistry, University of South Florida, 4202 East Fowler Ave, SCA 400, Tampa, FL 33620, USA
    Mol Cell Biochem 298:109-23. 2007
    Increased glucose flux through the hexosamine biosynthetic pathway (HBP) is known to affect the activity of a number of signal transduction pathways and lead to insulin resistance...
  61. ncbi Molecular cloning and functional analysis of zebrafish high-density lipoprotein-binding protein
    Jyh Yih Chen
    Marine Research Station, Institute of Zoology, Academia Sinica, 23 10, Dah Uen Rd, Jiaushi, Ilan 262, Taiwan, ROC
    Comp Biochem Physiol B Biochem Mol Biol 136:117-30. 2003
    High-density lipoprotein-binding protein (HBP) plays a pivotal role in the endocrine regulation of both lipids and cholesterol...
  62. ncbi Left ventricular hypertrophy in treated hypertensive patients with good blood pressure control outside the clinic, but poor clinic blood pressure control
    Cesare Cuspidi
    Instituto di Clinica Medica e Terapia Medica and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore IRCCS, Milan, Italy
    J Hypertens 21:1575-81. 2003
    ..ventricular hypertrophy (LVH) in treated patients with good blood pressure (BP) control during multiple home BP (HBP) measurements and during 24-h ambulatory BP monitoring (ABPM), but with unsatisfactory BP control in the clinic...
  63. ncbi Feeling anxious: a twin study of panic/somatic ratings, anxiety sensitivity and heartbeat perception in children
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1184-91. 2007
    ..Specifically, anxiety sensitivity (AS) and heartbeat perception (HBP) have been associated with panic in adults and children...
  64. pmc Magnetic resonance imaging of kidney and cyst volume in children with ADPKD
    Melissa A Cadnapaphornchai
    Department of Pediatrics, PKD Research Group, University of Colorado Denver, and Department of Radiology, The Children s Hospital, 13001 East 17th Place, Box C283, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 6:369-76. 2011
    ..However, no studies have examined the utility of MRI for serial assessment of kidney and cyst volume in children with ADPKD...
  65. ncbi Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues
    K Lorent
    Center for Human Genetics, Katholieke Universiteit Leuven, Belgium
    Differentiation 55:213-23. 1994
    ..receptor (alpha 2MR) and the receptor associated protein, the heparin binding protein-44 (alpha 2MRAP/HBP-44), a component of unknown function...
  66. ncbi Resting blood pressure and thermal pain responses among females: effects on pain unpleasantness but not pain intensity
    R B Fillingim
    Department of Psychology, University of Alabama at Birmingham 35274 1170, USA
    Int J Psychophysiol 30:313-8. 1998
    ..among females, this experiment studied 21 pain-free, normotensive females (mean age 23) classified as having high (HBP) vs. low blood pressure (LBP) based on a median split of resting blood pressure collected prior to thermal testing...
  67. pmc Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis
    Ben R Otto
    Department of Molecular Microbiology, Institute of Molecular Biological Sciences, Amsterdam, The Netherlands
    Infect Immun 70:5-10. 2002
    ..The role of the hemoglobin protease (Hbp) autotransporter protein from E. coli in the synergy of IAI was investigated...
  68. ncbi Managing worry, stress and high blood pressure: African-American women holding it together through 'family'
    D M Boutain
    Seattle University School of Nursing, Seattle, Washington, USA
    Ethn Dis 11:773-8. 2001
    Strategies to manage worry, stress and high blood pressure (HBP) are little understood from the perspective of African Americans...
  69. ncbi Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein
    Robert Sijbrandi
    Department of Molecular Microbiology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 278:4654-9. 2003
    Hemoglobin protease (Hbp) is a hemoglobin-degrading protein that is secreted by a human pathogenic Escherichia coli strain via the autotransporter mechanism. Little is known about the earliest steps in autotransporter secretion, i.e...
  70. ncbi Properties of protein powders from arrowtooth flounder (Atheresthes stomias) and herring (Clupea harengus) byproducts
    Subramaniam Sathivel
    Fishery Industrial Technology Center, School of Fisheries and Ocean Sciences, University of Alaska Fairbanks, 118 Trident Way, Kodiak, Alaska 99615, USA
    J Agric Food Chem 52:5040-6. 2004
    ..nutritional, and thermal properties of freeze-dried protein powders (FPP) from whole herring (WHP), herring body (HBP), herring head (HHP), herring gonad (HGP), and arrowtooth flounder fillets (AFP) were evaluated...
  71. ncbi Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension
    L E Bautista
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Hum Hypertens 19:149-54. 2005
    High blood pressure (HBP) has been associated with elevated C-reactive protein (CRP), a marker of chronic mild inflammation...
  72. ncbi Biodesulfurization of dibenzothiophene and other organic sulfur compounds by a newly isolated Microbacterium strain ZD-M2
    Wei Li
    Department of Environmental Engineering, Zhejiang University Yuquan Campus, Hangzhou, China
    FEMS Microbiol Lett 247:45-50. 2005
    ..and two sulfur-free products, 2-methoxybiphenyl (2-MBP) and biphenyl, were detected in addition to 2-hydroxybiphenyl (2-HBP). This strain can also totally degrade 4,6-dimethyl-DBT, thiophene, benzothiophene and 70% diphenylsulfide.
  73. ncbi The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients
    R Negro
    Department of Endocrinology, AUSL LE 1, P O V Fazzi, Piazza F Muratore, 73100, Lecce, Italy
    J Endocrinol Invest 29:957-61. 2006
    ..glucose, cholesterol, triglycerides, free fatty acids (FFA), steady-state plasma insulin and glucose (SSPG), 24-hBP were determined at the beginning and at the end of the study...
  74. ncbi [Prevalence of sleep apnea in men with metabolic syndrome and controlled hypertension]
    B Hansel
    Service d endocrinologie métabolisme et de prévention cardiovasculaire, Hopital de la Pitie Salpetriere, Paris
    Arch Mal Coeur Vaiss 100:637-41. 2007
    Abdominal obesity and high blood pressure (HBP) are known to be associated with sleep apnea syndrome (SAS)...
  75. ncbi Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biol Pharm Bull 31:527-30. 2008
    ..In the present study, we examined whether hop- and apple-derived polyphenols (HBP and ACT, respectively) inhibit PGE2 production by human gingival epithelial (HGE) cells stimulated with P...
  76. pmc Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages
    Oliver Soehnlein
    Department of Physiology and Pharmacology and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 118:3491-502. 2008
    ..to be due to proteins released from PMN primary granules; thorough investigation revealed heparin-binding protein (HBP) and human neutrophil peptides 1-3 (HNP1-3) as the mediators of the macrophage response to PMN secretion...
  77. ncbi [Effects of surfactant and solvent on the encapsulation efficiency and size in using double emulsion method for preparing bovine hemoglobin loaded nanoparticles as blood substitutes]
    Xiaolan Zhang
    Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26:116-21. 2009
    On the basis of previous researches, we have prepared Bovine hemoglobin-loaded nanoparticles (HbP), using the double emulsion method...
  78. doi The correlation between human adipose-derived stem cells differentiation and cell adhesion mechanism
    In Su Park
    Biomaterial Research Center, Division of Life Sciences, Korea Institute of Science and Technology, 39 1 Hawolgok, Seongbuk, Seoul 136 791, Republic of Korea
    Biomaterials 30:6835-43. 2009
    ..Cell adhesion on fibronectin (Fn) was inhibited by the heparin-binding peptide (HBP) in the presence of Mab 2253, but not by either Mab 2253 or HBP alone...
  79. doi Optimal schedule for home blood pressure monitoring based on a clinical approach
    Jouni K Johansson
    Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Peltolantie, Turku, Finland
    J Hypertens 28:259-64. 2010
    The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach.
  80. doi Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding protein
    Adam Linder
    Division of Infection Medicine, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden
    J Invest Dermatol 130:1365-72. 2010
    ..Analyses of release of the vasoactive heparin-binding protein (HBP) showed increased levels in the infected as compared with the noninfected areas...
  81. doi Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosis
    Uthra Rajamani
    Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
    Am J Physiol Cell Physiol 299:C139-47. 2010
    ..Since elevated flux through the hexosamine biosynthetic pathway (HBP) is closely linked with the diabetic phenotype, we hypothesized that hyperglycemia-mediated oxidative stress ..
  82. pmc Comparison of entropic contributions to binding in a "hydrophilic" versus "hydrophobic" ligand-protein interaction
    Neil R Syme
    Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Am Chem Soc 132:8682-9. 2010
    ..studied ligand binding thermodynamics for rMUP previously, the data we obtained in the present study for HBP enables a comparison of the driving forces for binding between these classically distinct binding processes in ..
  83. pmc The effect of minority status and rural residence on actions to control high blood pressure in the U.S
    Charles Ellis
    Department of Health Professions, Medical University of South Carolina, 135 Rutledge Ave, Charleston, SC 29425, USA
    Public Health Rep 125:801-9. 2010
    We examined actions to control high blood pressure (HBP) and health-care provider recommendations for blood pressure control among adults by racial/ethnic group and rural/urban residence.
  84. doi Hepatic enhancement during the hepatobiliary phase after gadoxetate disodium administration in patients with chronic liver disease: the role of laboratory factors
    Victoria Chernyak
    Department of Radiology, Montefiore Medical Center, Bronx, New York 10467, USA
    J Magn Reson Imaging 34:301-9. 2011
    To identify factors influencing hepatobiliary phase (HBP) hepatic enhancement on gadoxetate disodium-enhanced MRI in patients with chronic liver disease (CLD).
  85. doi Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study
    Michelle S Chew
    Section of Intensive Care, Department of Clinical Sciences, Malmo, Skane University Hospital, Lund University, 20502 Malmo, Sweden
    Inflamm Res 61:375-9. 2012
    Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock.
  86. pmc The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study
    John A Morrison
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr 160:590-597.e3. 2012
    To evaluate children's cardiovascular disease (CVD) risk factors as predictors of parents' subsequent CVD, type 2 diabetes mellitus (T2DM), and high blood pressure (HBP).
  87. pmc Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid
    Ramamurthi Vidya Priyadarsini
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India
    PLoS ONE 7:e34628. 2012
    ..of chlorophyllin and ellagic acid in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model by whole genome profiling using pangenomic microarrays...
  88. pmc High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescents
    Bonita Falkner
    Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pediatr 162:94-100. 2013
    To examine the relative effects of high blood pressure (HBP) and obesity on left ventricular mass (LVM) among African-American adolescents; and if metabolic or inflammatory factors contribute to LVM.
  89. ncbi Chlorophyllin abrogates canonical Wnt/β-catenin signaling and angiogenesis to inhibit the development of DMBA-induced hamster cheek pouch carcinomas
    Siddavaram Nagini
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India
    Cell Oncol (Dordr) 35:385-95. 2012
    ..We investigated the effect of chlorophyllin supplementation on Wnt/β-catenin and vascular endothelial growth factor (VEGF) signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model.
  90. doi [Is salt sensitive hypertension an inflammatory disease? Role of lymphocytes and macrophages]
    Rafael González-Toledo
    Departamento de Nefrología y Fisiología Renal, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico D F, Mexico
    Arch Cardiol Mex 82:312-9. 2012
    ..lymphocytic/macrophage tubulointerstitial infiltrate that blunts urinary sodium excretion and therefore promotes HBP. It has been shown that this structural damage has an inflammatory origin and that immunosuppresant drugs down-..
  91. pmc Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim)--a prospective, placebo-controlled, double-blind study
    Kirsi Maija Kaukonen
    Intensive Care Unit, Helsinki University Central Hospital, Helsinki, Finland
    BMC Infect Dis 13:51. 2013
    Heparin Binding Protein (HBP) is released to blood circulation from activated neutrophils in bacterial infections. It is a potential inducer of vascular leakage and precludes the development of septic shock...
  92. doi The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan
    Yutaka Imai
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University School of Pharmaceutical Sciences, Miyagi, Japan
    Hypertens Res 36:661-72. 2013
    Data regarding ambulatory blood pressure (ABP) or self-BP measurements at home (HBP) have been accumulated...
  93. ncbi Purification of heparin binding oviduct specific proteins and its effect on in vitro embryo development in cattle
    Aditya K Sharma
    Dairy Biotechnology Laboratory, Eastern Regional Station, National Dairy Research Institute, Kalyani 741 235, India
    Indian J Exp Biol 51:347-51. 2013
    ..The SDS-PAGE profile of eluted heparin binding protein (HBP) fraction showed bands between approximately 66-approximately 97 kDa, while heparin unbinding protein (HUBP) ..
  94. pmc Multilevel and spatial-time trend analyses of the prevalence of hypertension in a large urban city in the USA
    Longjian Liu
    Department of Epidemiology and Biostatistics, Drexel University School of Public Health, 1505 Race Street, Philadelphia, PA, 19102, USA
    J Urban Health 90:1053-63. 2013
    We aimed to test two hypotheses that (1) there were significant variations in the prevalence of hypertension (HBP) across neighborhoods in the city of Philadelphia and (2) these variations were significantly explained by the variations ..
  95. doi Changing relationship among clinic, home, and ambulatory blood pressure with increasing age
    George S Stergiou
    Hypertension Center, STRIDE Hellas 7, Third University Department of Medicine, Sotiria Hospital, Athens, Greece Electronic address
    J Am Soc Hypertens 9:544-52. 2015
    Studies in adults have shown similar levels of home (HBP) and daytime ambulatory blood pressure (dABP), which are lower than clinic blood pressure (CBP) measurements. This study investigated the impact of age on these differences...
  96. doi Seasonal variation in meteorological parameters and office, ambulatory and home blood pressure: predicting factors and clinical implications
    George S Stergiou
    Third University Department of Medicine, Hypertension Center STRIDE 7, Sotiria Hospital, Athens, Greece
    Hypertens Res 38:869-75. 2015
    ..Hypertensives on stable treatment were assessed in winter-1, summer and winter-2 with clinic (CBP), home (HBP) and 24-hour ambulatory BP (ABP)...
  97. doi Evaluation of Polymeric Nanomedicines Targeted to PSMA: Effect of Ligand on Targeting Efficiency
    Adrian V Fuchs
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Brisbane 4102, Australia
    Biomacromolecules 16:3235-47. 2015
    ..A hyperbranched polymer (HBP) was utilized as the nanocarrier and contained a fluorophore for tracking/analysis, whereas the pendant functional ..
  98. pmc Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release
    Johanna Snäll
    Department of Medicine Huddinge, Centre for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, S 141 86 Stockholm, Sweden
    Sci Rep 6:21288. 2016
    ..we explore neutrophil responses, in particular the release of sepsis-associated factors heparin-binding protein (HBP) and resistin in relation to specific bacterial stimuli and sepsis of varying aetiology...
  99. pmc Biocatalytic Desulfurization Capabilities of a Mixed Culture during Non-Destructive Utilization of Recalcitrant Organosulfur Compounds
    Wael Ismail
    Environmental Biotechnology Program, Life Sciences Department, College of Graduate Studies, Arabian Gulf University Manama, Bahrain
    Front Microbiol 7:266. 2016
    ..Biodesulfurization of DBT by resting cells of AK6 produced 2-hydroxybiphenyl (2-HBP) in addition to trace amounts of phenylacetate...
  100. pmc Ten-year Diabetes Risk Forecast in the Capital of Jordan: Arab Diabetes Risk Assessment Questionnaire Perspective-A Strobe-Complaint Article
    Ahmad Alghadir
    From the Department of Rehabilitation Sciences AA, HA, SA, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia Department of Physical Therapy AAA, Faculty of Rehabilitation Sciences, The University of Jordan, Amman, Jordan and Dr D Y Patil College of Physiotherapy SA, Dr D Y Patil Vidyapeeth, Pune, India
    Medicine (Baltimore) 95:e3181. 2016
    ..absence of daily physical activity, daily consumption of fruits/vegetables, presence of high blood pressure (HBP), and HBG were significantly associated with increased odds of high ARABRISK total scores...
  101. doi Relationship between office and home blood pressure with increasing age: The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO)
    Angeliki Ntineri
    Hypertension Center STRIDE 7, National and Kapodistrian University of Athens, Third Department of Medicine, Sotiria Hospital, Athens, Greece
    Hypertens Res 39:612-7. 2016
    Home blood pressure (HBP) measurements are known to be lower than conventional office blood pressure (OBP) measurements...

Research Grants67

  1. ELIZABETH ANN SCHLENK; Fiscal Year: 2014
    ..At least half of those with OA of the knee are diagnosed with hypertension or high blood pressure (HBP), one of the most prevalent risk factors for cardiovascular disease...
  2. Non-Modulation Phenotype and Vascular Dysfunction in Diabetes Mellitus
    Gordon H Williams; Fiscal Year: 2010
    ..Likewise, in hypertension (HBP), control of blood pressure is important, but not sufficient to maximally reduce CV complications...
  3. Text Messaging to Improve Hypertension Medication Adherence in African Americans
    NANCY TRYGAR ARTINIAN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Uncontrolled high blood pressure (HBP) is a major public health concern and leading cause of cardiovascular disease worldwide...
  4. JARROD W BARNES; Fiscal Year: 2016
    ..NO deficiency in IPAH result from increased glucose uptake and activation of the hexosamine biosynthetic pathway (HBP). The hypothesis has been formulated based on previously generated preliminary data...
  5. Understanding Disparities in Obesity and its Comorbidities in the US
    Youfa Wang; Fiscal Year: 2010
    ..PA), two key modifiable risk factors for many chronic diseases including Type 2 diabetes (T2D) and hypertension (HBP). National data show large ethnic/SES disparities in obesity, T2D, HBP and healthcare...
  6. Zhiyong Zhao; Fiscal Year: 2016
    ..disturbs glucose metabolism (glycolysis) in the embryo, augmenting the hexosamine biosynthetic pathway (HBP) to produce high levels of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc)...
  7. Development of RIP-Chip methods and tiled arrays to identify functional elements
    Michael L Whitfield; Fiscal Year: 2010
    ..IPs) followed by microarray analysis (RIP-Chip) to identify the targets of the histone stem-loop binding protein (SLBP) with high confidence...
  8. HEXOSAMINES, GLUCOSE TOXICITY AND INSULIN RESISTANCE
    Donald A McClain; Fiscal Year: 2013
    ..The hexosamine biosynthesis pathway (HBP) provides the substrate for this modification, UDP-GlcNAc...
  9. Danesh Moazed; Fiscal Year: 2014
    ..The SIR complex is composed of the NAD-dependent deacetylase Sir2, the histone binding protein Sir3, and an adaptor protein Sir4. The nucleator proteins recruit the SIR complex to DNA...
  10. Samuel Waxman; Fiscal Year: 2015
    ..to a limited number of SID transcription factors including REST, MAD1, KLF-9, -10, -11, -13 and -16, UME6 and HBP predicts a more selective epigenetic effect than treatment with HDAC inhibitors or demethylating agents...
  11. Mechanisms of Membrane-Based Insulin Resistance &Therapeutic Reversal Strategies
    Jeffrey S Elmendorf; Fiscal Year: 2012
    ..New data also suggest that increased hexosamine biosynthesis pathway (HBP) activity promotes PM cholesterol accrual, membrane/cytoskeletal defects, and insulin resistance...
  12. Ming Ming Zhou; Fiscal Year: 2016
    ..Over the past years, we have elucidated the structure and mechanism of histone modifying enzymes and histone binding protein domains...
  13. William F Marzluff; Fiscal Year: 2016
    ..These mRNAs end in a conserved stemloop, which interacts with the stemloop binding protein, SLBP. The stem-loop/SLBP complex functions in all steps of histone mRNA metabolism in place of the polyA tail...
  14. O-linked glycosylation and synaptic function in hippocampus
    LORI LYNN contact MCMAHON; Fiscal Year: 2010
    ..glucose is processed through the glycolytic pathway;while 2-4% is process via the hexosamine biosynthetic pathway (HBP)...
  15. The role of Myocardial Substrate Metabolism in Heart Failure
    MOGAMMAD FAADIEL ESSOP; Fiscal Year: 2013
    ..The general hypothesis is that oxidative stress resulting from intake of high glycemic foods activates the HBP leading to increased O-GlcNAcylation of cardiac apoptotic proteins and elevated myocardial apoptosis, thereby ..
  16. LORI LYNN MCMAHON; Fiscal Year: 2015
    ..is metabolized through the glycolytic pathway, but 2-4 % is metabolized via the hexosamine biosynthetic pathway (HBP)...
  17. Elucidating modulators of hepatic metabolism by quantitative flux analysis
    Gregory Stephanopoulos; Fiscal Year: 2010
    ..Specifically, we have recently discovered that the flux modulation of the hexosamine biosynthetic pathway (HBP) in hepatocytes affects their insulin sensitivity as measured by either glycogen deposition or glucose output...
  18. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..quintana's major hemin receptor and four homologues. Specific Aim 1 will quantify hbp expression in response to varying hemin concentration using RT-PCR...
  19. DISTRIBUTION OF IRON AND HEME BY PROTEINS
    URSULA MULLER EBERHARD; Fiscal Year: 1993
    ..One of these proteins, heme binding protein (HBP) isolated in this laboratory from rat liver cytosol, promotes the efflux of heme from mitochondria, the site of ..
  20. TRANSCRIPTIONAL REPRESSION AND CELL CYCLE MECHANISMS
    Amy Yee; Fiscal Year: 2000
    ..To this end, we have isolated HBP-1, a new sequence specific HMG transcription factor, as a specific interactor of the RB family in differentiated ..
  21. VASCULAR DISEASE IN HBP--ANGII, PAI1, INSULIN AND GENES
    Gordon Williams; Fiscal Year: 2001
    ..With this information, specific preventive and therapeutic measures to retard the development of these complications could be proposed and tested in a clinical trial's format. ..
  22. Cytoplasmic Glycosylation and Hypovolemic Stress
    RICHARD MARCHASE; Fiscal Year: 2007
    ..stress-activated, pro-survival pathway triggered by increased flux through the hexosamine biosynthesis pathway (HBP)...
  23. DATABASES AND DATA MODELS ENABLING NEUROINFORMATICS
    Daniel Gardner; Fiscal Year: 2009
    ..Web resources will support sharing of neurophysiology data and present techniques for Human Brain Project (HBP) interoperability: neurodatabase.org, brainml.org, and datasharing.net...
  24. 'GENETIC & ENVIRONMENTAL DETERMINANTS OF HYPERTENSION'
    Roger Williams; Fiscal Year: 1991
    ..The long term goal is to understand the pathophysiology of different types of essential hypertension (HBP)...
  25. Trial of Decision Support to Improve Diabetes Outcomes
    RANDALL CEBUL; Fiscal Year: 2006
    ..guidelines exist for control of glycemia (A1c levels), lipid abnormalities (LDL levels), hypertension (HBP), kidney and eye disease, yet gaps exist between what can be achieved and current performance...
  26. Mechanisms of Aldosterone Induced Cardiovascular Damage
    Gordon Williams; Fiscal Year: 2006
    ..in relation to sodium (Na) intake are an important link between CV damage and heart failure, hypertension (HBP) and/or diabetes mellitus...
  27. Reducing Total Cardiovascular Risk in an Urban Community
    Jerilyn Allen; Fiscal Year: 2009
    ..The benefits of controlling high blood pressure (HBP) are well established yet national rates of HBP control remain at only 3 1% despite decades of provider and patient ..
  28. Patient-Physician Partnership to Improve HBP Adherence
    Lisa Cooper; Fiscal Year: 2004
    ....
  29. Barriers to HBP Care and Control in Black South Africans
    Martha Hill; Fiscal Year: 2004
    ..abstract_text> ..
  30. KOREAN AMERICAN ELDERLY WITH HIGH BLOOD PRESSURE
    Miyong Kim; Fiscal Year: 2001
    ..culturally sensitive, built on valid behavioral theory and principles, improves the control of high blood pressure (HBP), and enhance health related quality of life...
  31. Skeletal muscle nutrient sensing
    Silvana Obici; Fiscal Year: 2006
    ..A major nutrient-sensing pathway, the hexosamine biosynthetic pathway (HBP) has been recently shown to increase local leptin expression in skeletal muscle...
  32. FAMILIAL AGGREGATION OF FAT PATTERNS & DISEASE
    Maria Ramirez; Fiscal Year: 1992
    ..the distribution of relative fat patterns (RFP), and to test for associations of fat patterning with hypertension (HBP) and non-insulin dependent diabetes (NIDDM). The study has the following major objectives: 1...
  33. A Novel Factor Involved in Translation of Histone mRNA and Subsets of PolyA mRNA
    RACHEL LERNER; Fiscal Year: 2009
    ..This unique 3'end is bound by the stemloop binding protein (SLBP), which plays a role in histone mRNA processing, translation, and degradation...
  34. Excess nutrients and the metabolic syndrome of aging
    Nir Barzilai; Fiscal Year: 2007
    ..The hexosamine biosynthetic pathway (HBP) may provide a unifying role as a 'nutrient-sensing' pathway, since its activation by nutrient excess ..
  35. MOTIVATIONAL INTERVENTION FOR PREGNANT SMOKERS
    Karen Emmons; Fiscal Year: 1999
    ..The smoking intervention will be conducted in the context of the Healthy Baby Program (HBP), an innovative community based outreach program that addresses basic life needs and medical care issues for ..
  36. High Blood Pressure Care for Korean Americans
    Miyong Kim; Fiscal Year: 2005
    ..built on valid behavioral theories and principles, and aimed at improving the control of high blood pressure (HBP) and enhancing health related quality of life...
  37. Health Literacy Intervention for Korean Americans with HPB
    Miyong T Kim; Fiscal Year: 2010
    ..participatory research (CBPR) process will be effective in promoting health literacy and achieving better HBP outcomes in a community that is known as one of the "hard-to reach" populations for clinical research;and (2) an ..
  38. Diabetes Care for Korean Americans
    Miyong Kim; Fiscal Year: 2007
    ..Insights gained in this pilot investigation should help us to develop effective, culturally sensitive self-help protocols for wider application to KAI with type 2 DM in metropolitan areas throughout the U.S. [unreadable] [unreadable]..
  39. Better Breast Health for Korean American Women
    Hae Ra Han; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. Cardiovascular Disease: Depression and Telomere Length
    Daichi Shimbo; Fiscal Year: 2010
    ..The reasons for this relation are not well known. This study will help determine why depression increases the risk of cardiovascular disease and may suggest ways to develop more effective preventive and treatment strategies. ..
  41. Translational Study of Hostility, Atherothrombosis & CAD
    Daichi Shimbo; Fiscal Year: 2007
    ..Data from this translational research program will allow Dr. Shimbo to establish an empirical foundation from which to apply these data to the development of effective preventive interventions for hostile patients. ..
  42. HYPERGEN
    Steven Hunt; Fiscal Year: 1999
    ..Sample" using previously collected DNA samples and extensive phenotype data already entered into computer for 793 persons in 135 Utah families with hypertension (including 245 HBP sibpairs, plus normotensive relatives and spouses).
  43. COMPREHENSIVE HIGH BLOOD PRESSURE CARE IN YOUNG URBAN BL
    Martha Hill; Fiscal Year: 2003
    ..hypertensive black men, the age-sex-race group which suffers disproportionately from premature high blood pressure (HBP) related morbidity and mortality...
  44. CHROMIUM ENHANCES INSULIN & GLUT4 ACTION VIA LIPID RAFTS
    JEFFREY ELMENDORF; Fiscal Year: 2008
    ..abstract_text> ..
  45. HIGH THROUGHPUT GENOME ANALYSIS SYSTEM
    William Marzluff; Fiscal Year: 2001
    ..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
  46. CALCIUM REGULATION IN THE DIABETIC HEART
    Amy Davidoff; Fiscal Year: 2001
    ..The adult myocyte culture system provides a well-defined method from elucidating fundamental mechanisms of high glucose that may contribute to the development of myocyte dysfunction in diabetes. ..
  47. Trends in blood pressure in relation to obesity
    Rebecca Din Dzietham; Fiscal Year: 2005
    ..Research findings would lead to more refined mechanistic studies for ultimately better tailored interventions. ..
  48. Binding Network of Pol Eta in DNA Damage Responses
    Christoph Borchers; Fiscal Year: 2003
    ..abstract_text> ..
  49. Phosphorylation dependent recognition of a histone mRNA hairpin by SLBP
    William Marzluff; Fiscal Year: 2009
    PROVIDED. The objective of this proposal is to determine the structural basis of how the Stem-Loop Binding Protein (SLBP) functions to regulate histone mRNA processing and translation...
  50. BIRTH WEIGHT EFFECT ON BLOOD PRESSURE IN LATE CHILDHOOD
    Bonita Falkner; Fiscal Year: 2001
    ..Alternatively, if post-natal/childhood parameters are the major determinants of later BP, then efforts should focus on effective preventive strategies in childhood, such as obesity. ..
  51. DIABETIC ALTERATIONS OF CARDIAC METABOLISM AND FUNCTION
    John Chatham; Fiscal Year: 2003
    ....
  52. DIABETIC CARDIOMYOPATHY - ROLE OF INSULIN RESISTANCE
    Amy Davidoff; Fiscal Year: 2003
    ..The development of cellular insulin resistance is likely to be a key factor in the etiology of diabetic cardiomyopathy and may represent the recapitulation of fetal gene expression, as shown for hypertrophic myocardium. ..
  53. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  54. FACTORS THAT MODIFY INSULIN ACTION
    MARIA BUSE; Fiscal Year: 2008
    ..Understanding how different excess nutrients modify insulin[unreadable]s signalling may lead to the rational development of novel therapeutic targets. ..
  55. Inflammation and Injury in Obesity Hypertension in African American Adolescents
    Bonita Falkner; Fiscal Year: 2010
    ..abstract_text> ..
  56. Androgens and Cardiovascular Risk in African Americans
    Bonita Falkner; Fiscal Year: 2005
    ..The results of this project can contribute to the development of prevention and earlier intervention strategies, including more specific therapeutic targets, for this high-risk minority population. ..
  57. Screen for molecules inhibiting histone pre-mRNA process
    William Marzluff; Fiscal Year: 2006
    ..We are adapting the screen to an automated microscope which can rapidly read the 384 well plates. ..
  58. Mitotic Checkpoint Regulators: Roles in Development and Cancer
    William F Marzluff; Fiscal Year: 2010
    ....
  59. TGF-Beta, Glucose and Nephropathy in African Americans
    Bonita Falkner; Fiscal Year: 2007
    ..abstract_text> ..
  60. How do oocytes & embryos cope with adverse environments?
    Jeremy Thompson; Fiscal Year: 2007
    ..This knowledge will also assist health professionals develop strategies to reduce the risk of adult onset diseases caused by perturbed early development. ..
  61. Vascular Alterations in the Prediabetic Condition
    Cynthia Cheng; Fiscal Year: 2008
    ....
  62. Mechanisms of glucosamine ischemic cardioprotection
    John C Chatham; Fiscal Year: 2010
    ..protein kinase (MARK) and protein kinase C (PKC) that have been shown to be modulated in response to increased HBP flux as well as implicated in ischemic cardioprotection, also mediate glucosamine-induced cardioprotection;4) ..
  63. Realizing the potential of reference ontologies for the semantic web
    James F Brinkley; Fiscal Year: 2010
    ..Their development and evaluation will primarily be driven by the need to integrate data and computational models describing cardiac function. ..
  64. Type-2 Diabetes and Cardiac Dysfunction
    John Chatham; Fiscal Year: 2009
    ..High levels of glucose activate the hexosamine biosynthesis pathway (HBP) and increase the levels of N-acetylglucosamine (O-GlcNAc) on cytoplasmic and nuclear proteins...