Gene Symbol: SIK1
Description: salt inducible kinase 1
Alias: EIEE30, MSK, SIK, SNF1LK, SIK-1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible kinase 1, salt-inducible protein kinase 1, serine/threonine protein kinase, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Species: human

Top Publications

  1. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
  2. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  3. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  4. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
  5. pmc SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
    Hailing Cheng
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Sci Signal 2:ra35. 2009
  6. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
  7. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
  8. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
  9. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
  10. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994

Detail Information

Publications290 found, 100 shown here

  1. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
    ..We have identified an inducible gene target of TGFbeta/Smad signaling, the salt-inducible kinase (SIK), which negatively regulates signaling together with Smad7...
  2. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  3. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
  4. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  5. pmc SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
    Hailing Cheng
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Sci Signal 2:ra35. 2009
    ..Here, through the use of a kinome-wide loss-of-function screen, we identify the serine-threonine kinase SIK1 (salt-inducible kinase 1) as a regulator of p53-dependent anoikis...
  6. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
    ..b>Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain ..
  7. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
    ..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
  8. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  9. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
    ..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
  10. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  11. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  12. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001
  13. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  14. ncbi Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disorders
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 31:274-9. 2004
  15. ncbi Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
    J H Stack
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
    J Biol Chem 269:31552-62. 1994
    ..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
  16. ncbi Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
    M S Schwab
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
    Curr Biol 11:141-50. 2001
    ..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
  17. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    ..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
  18. ncbi Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  19. ncbi The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes
    P Brunovskis
    Department of Microbiology, Michigan State University, East Lansing 48824 1101
    Virology 206:324-38. 1995
    ..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
  20. pmc Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
    Liliana Endo-Munoz
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Virol J 2:17. 2005
    ..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
  21. ncbi The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domains
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Theor Appl Genet 113:1147-58. 2006
    ..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
  22. ncbi A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
    Eur J Biochem 267:3744-52. 2000
    ..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
  23. doi Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
    Julie C Fanburg-Smith
    Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 14:8-14. 2010
    ..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
  24. ncbi Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
    P Komalavilas
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 274:34301-9. 1999
    ..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
  25. ncbi Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  26. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  27. ncbi Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
    S Sturany
    Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
    J Biol Chem 276:3310-8. 2001
    We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene...
  28. ncbi Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
    Norbert Nagy
    FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
    J Mol Cell Cardiol 42:981-90. 2007
    ..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
  29. ncbi The HIV Dementia Scale: predictive power in mild dementia and HAART
    Kara Anne Bottiggi
    Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
    J Neurol Sci 260:11-5. 2007
    ..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
  30. ncbi Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children
    Victoria A Cukiernik
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 41:1368-74. 2007
    Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
  31. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  32. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
  33. ncbi On the physiological role of casein kinase II in Saccharomyces cerevisiae
    C V Glover
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Prog Nucleic Acid Res Mol Biol 59:95-133. 1998
  34. ncbi Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney
    T Yagisawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 37:1140-3. 2001
    Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
  35. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
  36. pmc Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    M K Webster
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:2031-40. 1993
  37. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  38. pmc Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
    Eri Sakurai
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Pain 5:74. 2009
    ..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
  39. ncbi Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s
    G Gambaro
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Kidney Int 69:663-70. 2006
    ..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
  40. doi The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro
    Carmen Giefing
    Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
    Microbiology 156:1697-707. 2010
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
  41. doi The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis
    Cristina Purcarea
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
    Mol Cell Biochem 311:199-213. 2008
    ..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
  42. ncbi Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A
    Harold I Calvin
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Curr Eye Res 27:269-78. 2003
    ..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
  43. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  44. doi [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]
    M Streibelt
    Charite Universitatsmedizin Berlin
    Rehabilitation (Stuttg) 48:135-44. 2009
    ..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
  45. doi Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
  46. ncbi Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
    J Rheumatol 32:1341-8. 2005
    ..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
  47. ncbi Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspective
    Brian J Krabak
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Phys Med Rehabil 86:493-8. 2007
    ..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
  48. ncbi [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]
    Li jun Zhao
    Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009
    ..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
  49. doi Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model
    Vaijayanti Lagu Joshi
    Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
    J Rheumatol 36:614-22. 2009
    To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
  50. ncbi Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
    P C Scacheri
    National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Genesis 30:259-63. 2001
    ..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
  51. ncbi A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings
    J A Forster
    Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
    Urol Int 78:264-9. 2007
    Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
  52. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
  53. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
  54. ncbi Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain
    K Nara
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Eur J Biochem 268:2642-51. 2001
    ..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
  55. ncbi The physical association of casein kinase 2 with nucleolin
    D Li
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:15662-8. 1996
    ..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
  56. ncbi Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  57. pmc ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression
    J Montalvo
    Ghosh Science and Technology Center, Department of Biology, Worcester State University, Worcester, Massachusetts, USA
    Curr Mol Med 13:205-19. 2013
  58. doi Differential transcript regulation in Arabidopsis thaliana and the halotolerant Lobularia maritima indicates genes with potential function in plant salt adaptation
    Olga V Popova
    Department of Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, 33615 Bielefeld, Germany
    Gene 423:142-8. 2008
  59. pmc A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1
    Haidan Liu
    University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 Phone 507 437 9600 Fax 507 437 9606 and Bo Yeon Kim, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363 883, Republic of Korea
    Cancer Prev Res (Phila) 7:74-85. 2014
  60. pmc Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes
    Karen Wallace
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE24HH, UK
    J Cell Sci 124:405-13. 2011
  61. pmc Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice
    S Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Br J Pharmacol 149:687-702. 2006
    ..Here, we have investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, in a mouse model of carrageenan-induced pleurisy...
  62. ncbi Role of cdk5 in the pathogenesis of Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Neurosignals 12:209-14. 2003
    ..The mechanisms for this potentially damaging activity of cdk5 are largely unknown although amyloid precursor protein and presenilin-1 are both cdk5 substrates...
  63. doi AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
    Alice Mayer
    Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Gosselies, Belgium
    Eur J Immunol 38:948-56. 2008
    ..In conclusion, AMPK represents an important enzyme allowing lymphocytes to resist a mild energy crisis in vitro, but is largely dispensable for activation and expression of effector function in response to antigen stimulation...
  64. doi Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt
    Shinsuke Nakamura
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Exp Eye Res 90:137-45. 2010
    ..Ruboxistaurin may be a candidate for treatment of angiogenesis in retinal neovascularization diseases...
  65. pmc Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis
    Eric Ackah
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Clin Invest 115:2119-27. 2005
    ..Thus, the Akt1 isoform exerts an essential role in blood flow control, cellular migration, and NO synthesis during postnatal angiogenesis...
  66. pmc Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
    ..The screen identified moleskin (msk) as important for the nuclear import of phosphorylated Mad...
  67. ncbi The human desmin locus: gene organization and LCR-mediated transcriptional control
    Jennifer L Y Tam
    Nuclear Biology Group, Department of Medical and Molecular Genetics, King s College London School of Medicine, King s College London Guy s Campus, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Genomics 87:733-46. 2006
    ..The DES LCR may therefore regulate expression of SPEG and APEG1 as well as DES...
  68. ncbi Musculoskeletal imaging at 3T: current techniques and future applications
    Timothy J Mosher
    Department of Radiology, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Magn Reson Imaging Clin N Am 14:63-76. 2006
    b>MSK MR imaging applications are making the transition rapidly from 1.5T to 3T...
  69. doi Physiological functions of protein kinase D in vivo
    Kornelia Ellwanger
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Stuttgart, Germany
    IUBMB Life 65:98-107. 2013
    ..Here, we highlight the current state of in vivo studies on PKD function with a focus on animal models and discuss the molecular basis of the observed phenotypic characteristics associated with this kinase family...
  70. ncbi Musculoskeletal pain in the adult New Zealand population: prevalence and impact
    William Taylor
    Rehabilitation Teaching and Research Unit, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
    N Z Med J 118:U1629. 2005
    A pilot study to determine the response rate and feasibility of a postal survey to measure the population frequency of site-specific musculoskeletal (MSK) pain and associated health related quality of life (HRQOL).
  71. ncbi The role of integrin-linked kinase (ILK) in cancer progression
    Sujata Persad
    Hamilton Regional Cancer Center and McMaster University, Hamilton, Ontario, Canada
    Cancer Metastasis Rev 22:375-84. 2003
    ..In this review, we summarize the adaptor and signaling properties ofILK, and also progress in the identification of therapeutic strategies for inhibition of ILK activity...
  72. pmc DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase
    R E Hollingsworth
    Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver 80262
    Proc Natl Acad Sci U S A 87:6272-6. 1990
    ..Because Cdc7 kinase acts downstream of Cdc28/cdc2 kinase function at "start," the transition from G1 to S phase in the cell cycle may be the result of a cascade of protein phosphorylation...
  73. ncbi The Dstpk61 locus of Drosophila produces multiple transcripts and protein isoforms, suggesting it is involved in multiple signalling pathways
    D Clyde
    Institute of Cell and Molecular Biology, The University of Edinburgh, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Endocrinol 167:391-401. 2000
    The Drosophila gene Dstpk61 encodes a serine threonine protein kinase homologous to human phosphoinositide-dependent protein kinase (PDK1), and also has homologues in S. cerevisiae, S. pombe, C. elegans, A. thaliana, mouse, and sheep...
  74. pmc The metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow trout
    Sergio Polakof
    INRA, UR1067 Nutrition Metabolism Aquaculture, Saint Pée sur Nivelle, France
    PLoS ONE 6:e20228. 2011
  75. doi Silencing of polo-like kinase 2 increases cell proliferation and decreases apoptosis in SGC-7901 gastric cancer cells
    Li Ying Liu
    Center Laboratory of Biomedical Research, Key Laboratory of Environment and Genes Related to Diseases of Chinese Ministry of Education, Xi an Jiaotong University Health Science Center, Xi an, Shaanxi 710061, P R China
    Mol Med Rep 11:3033-8. 2015
    ..In conclusion, these results suggested that PLK2 may act as a tumor suppressor in gastric cancer, therefore indicating its therapeutic potential...
  76. ncbi Dose-dependent impairment of inhibitory avoidance retention in rats by immediate post-training infusion of a mitogen-activated protein kinase kinase inhibitor into cortical structures
    R Walz
    Centro de Memoria, Departamento de Bioquimica, ICBS, U F R G S, Porto Alegre, RS, Brazil
    Behav Brain Res 105:219-23. 1999
    ..The effective dose is variable according to the neocortical structure studied...
  77. doi A-Raf: A new star of the family of raf kinases
    Su An
    a Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China and
    Crit Rev Biochem Mol Biol 50:520-31. 2015
    ..We also describe the scaffold functions of A-Raf and summarize the unexpected complexity of Raf signaling...
  78. pmc Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB
    Jinwoo Lee
    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI, USA Endocrinology and Reproductive Physiology Program, University of Wisconsin, Madison, WI, USA
    Mol Cell Endocrinol 408:80-9. 2015
    ..StAR transcription, splicing and post-transcriptional processing, which are synchronized by salt inducible kinase (SIK1) and CREB-regulated transcription coactivator (CRTC2)...
  79. doi UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells
    José Edgar Nicoletti-Carvalho
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Prof Lineu Prestes Ave 1524, 05508 900 Sao Paulo, SP, Brazil
    J Endocrinol 206:183-93. 2010
    ..In this way, CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT...
  80. ncbi The outwardly rectifying chloride channel in rat peritoneal mast cells is regulated by serine/threonine kinases and phosphatases
    Jörg Seebeck
    Department of Pharmacology, University of Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    Pflugers Arch 443:558-64. 2002
    ..Our findings suggest that I(Cl,OR) in RPMCs is activated by a PKA-type protein kinase, a process which is antagonized functionally by okadaic acid- and cantharidin-sensitive protein phosphatases...
  81. ncbi [Cardiac, respiratory and sleep disorders in patients with myotonic dystrophy]
    Marta Banach
    Pracownia EMG, Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie
    Przegl Lek 66:1065-8. 2009
    ..This paper is aimed at characterizing some common cardiologic and sleep related respiratory disorders of patients with myotonic dystrophy which if not recognized in good time may lead to sudden death...
  82. ncbi Herpes simplex virus type 2: unique biological properties include neoplastic potential mediated by the PK domain of the large subunit of ribonucleotide reductase
    L Aurelian
    Virology Immunology Laboratories, Department of Pharmacology and Experimental Therapeutics, The University of Maryland School of Medicine, Ten South Pine Street, Baltimore MD 21201, USA
    Front Biosci 3:d237-49. 1998
    ..In cultured cells, RR1 PK is required for viral IE gene transcription. In vivo, RR1 PK is likely to be involved in latency reactivation...
  83. ncbi Down-regulation of protein kinase CKII activity by sodium butyrate
    G L Russo
    I S A Institute of Food Science and Technology, National Research Council, Avellino, Italy
    Biochem Biophys Res Commun 233:673-7. 1997
    ..The data reported provide the first evidence that CKII down-regulation is involved in the signal transduction pathway started by butyrate...
  84. ncbi Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
    K Reif
    Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 272:14426-33. 1997
  85. doi Human with-no-lysine kinase-4 3'-UTR acting as the enhancer and being targeted by miR-296
    Jinyuan Mao
    Department of Medical Genetics, China Medical University, No 92 Bei Er Road, Shenyang 110001, China
    Int J Biochem Cell Biol 42:1536-43. 2010
    ..The coordinated modulation of miR-296 and cofactors on the 3'-UTR may be attributed to hWNK4 physiopathological function...
  86. ncbi Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis
    P D Walden
    Department of Urology, NYU Medical Center, New York 10016, USA
    Biol Reprod 55:1039-44. 1996
    ..MAST205 mRNA was detected in human testis indicative of conservation in other mammalian species. Taken together, these results indicate that the MAST205 complex functions in spermatid maturation in mammals...
  87. doi Knockdown of ILK inhibits glioma development via upregulation of E-cadherin and downregulation of cyclin D1
    Kebin Zheng
    Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P R China
    Oncol Rep 34:272-8. 2015
    ..Our results suggest that ILK may serve as a promising therapeutic target for glioma...
  88. pmc Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
    Maroof Hasan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390
    J Immunol 195:4573-7. 2015
    ..Together, our findings provided critical experimental evidence for inhibiting TBK1 with Compound II as an effective treatment for TREX1-associated autoimmune diseases and potentially other interferonopathies. ..
  89. pmc Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes
    R S Freeman
    Department of Chemistry, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 86:5805-9. 1989
    ..These results demonstrate that the mosxe-encoded protein can induce progression through the cell cycle for both meiotic and mitotic cells and that this property is dependent on the presumptive ATP-binding domain in the protein kinase...
  90. pmc Cytokines in acute chikungunya
    Anuradha Venugopalan
    Center for Rheumatic Diseases, Pune, India
    PLoS ONE 9:e111305. 2014
    Acute chikungunya (CHIKV) is predominantly an acute onset of excruciatingly painful, self-limiting musculoskeletal (MSK) arbovirus illness and this was further reported by us during the 2006 Indian epidemic [Chopra et al...
  91. ncbi miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2
    Mifang Yang
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, PR China
    Anticancer Agents Med Chem 14:884-91. 2014
    ..Overall, on the basis of the results of our study, we proposed that miR-1271 could regulate cisplatin resistance in human gastric cancer cells, at least partially, via targeting the IGF1R/IRS1 pathway...
  92. pmc Targeting the AMPK pathway for the treatment of Type 2 diabetes
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Department Endocrinology, Metabolism and Cancer, Paris, France
    Front Biosci (Landmark Ed) 14:3380-400. 2009
    ..In the present review, we update these topics and discuss the concept of targeting the AMPK pathway for the treatment of type 2 diabetes...
  93. doi TRPM6
    Vladimir Chubanov
    Walther Straub Institute for Pharmacology and Toxicology, Ludwig Maximilians University Munich, Goethestrasse 33, Munich, 80336, Germany
    Handb Exp Pharmacol 222:503-20. 2014
    ..In contrast, Trpm6 null mice show a delay in prenatal development, neural tube defects, and prenatal death. Possible functions of TRPM6 in prenatal and adult organisms will be discussed in this chapter. ..
  94. pmc Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity
    Abujiang Pataer
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Biol Ther 8:245-52. 2009
    ..Our results suggest a rationale to develop therapeutic strategies that target PKR signaling in human cancer cells...
  95. doi IPA3 non-specifically enhances phosphorylation of several proteins in human platelets
    Rachit Badolia
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Platelets 26:501-3. 2015
    ..In summary, we demonstrate that IPA3 by itself can phosphorylate several proteins in human platelets and thus its use is not an appropriate strategy for investigating PAK function in platelets. ..
  96. doi BRAF mutation testing in clinical practice
    James Ziai
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Expert Rev Mol Diagn 12:127-38. 2012
    ..BRAF mutation testing using highly sensitive and specific methodology in a molecular diagnostic laboratory is essential in the current clinical practice of oncology...
  97. doi Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge
    Annayya R Aroor
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, United States
    Eur J Pharmacol 679:101-8. 2012
    ..of hepatocytes with ethanol caused increased phosphorylation of p38 MAPK (mitogen activated protein kinase), MSK-1 (mitogen and stress activated kinase) and CREB in the nuclear compartment without activation of ERK1/2 (..
  98. doi Identification of nickel response genes in abnormal early developments of sea urchin by differential display polymerase chain reaction
    Tae Kwon Ryu
    Risk Assessment Division, National Institute of Environmental Research, Incheon 404 708, Republic of Korea
    Ecotoxicol Environ Saf 84:18-24. 2012
    ..This result may prove useful in the development of novel biomarkers for the assessment of heavy metal stresses on sea urchin embryos...
  99. doi CDNA cloning and characterization of S6 kinase and its effect on yolk protein gene expression in the oriental fruit fly Bactrocera dorsalis (Hendel)
    R Suganya
    Department of Entomology, National Chung Hsing University, Taichung City, Taiwan, Republic of China
    Arch Insect Biochem Physiol 78:177-89. 2011
    ..Knockdown of BdS6K gene by RNA interference in the adult significantly decreased the YP expression. These observations support the involvement of BdS6K signaling in the regulation of the YP synthesis and egg development in B. dorsalis...
  100. pmc Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway
    X L Jin
    Human Reproduction Unit, Disciplines of Physiology and Medicine, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales 2065, Australia
    Biol Reprod 80:286-94. 2009
    ..The study identifies trophic ligand signaling via the activation of phosphatidylinositol-3 kinase and AKT as a mechanism resulting in the activation of MDM2...
  101. pmc Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
    Oksana Kaidanovich-Beilin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Mol Brain 2:35. 2009
    ..In this study, we have characterized brain functions of GSK-3alpha KO mice by using a well-established battery of behavioral tests together with neurochemical and neuroanatomical analysis...

Research Grants63

  1. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
  2. LKB1- AMPK pathway regulation of glucose metabolism and metformin action in liver
    REUBEN JAMES SHAW; Fiscal Year: 2013
    ..In Aim 1, the role of AMPKalpha1, AMPKalpha2, and the related SIK kinases will be compared in control of hepatic glucose metabolism using novel temporally controlled genetic mouse ..
  3. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  4. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
    ..which in turn causes phenotypic changes, and if inhibition of MSK1 by its chemical inhibitor and shRNA or using a MSK KO mouse blocks alcohol-induced cell transformation and Pol III gene transcription;2) if alcohol-induced H3ph ..
  5. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  6. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    ..In addition, drugs that decrease SK2-associated CK2 activity and thereby decrease neuronal excitability may be therapeutic avenues for treatments of hyperexcitability disorders such as schizophrenia and epilepsy. ..
  7. mTOR, a new target for opioid-induced tolerance and hyperalgesia
    Myron Yaster; Fiscal Year: 2013
    ..Because mTOR inhibitors are FDA-approved drugs, our studies may also have a strong potential clinical application in treating and/or preventing opioid-induced analgesic tolerance and hyperalgesia. ..
  8. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..abstract_text> ..
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  10. Evaluation of the in vivo effects of genes regulating Ataxin1 levels in SCA1 mice
    Qiumin Tan; Fiscal Year: 2013
    ..In Aim 1, I will study the role of MSK paralogs in SCA1 pathogenesis by performing genetic studies of Msk1 and Msk2, in the SCA1 mouse model and ..
  11. The role of SIK1 in myogenic differentiation and skeletal muscle repair
    Rebecca L Berdeaux; Fiscal Year: 2013
    ..We identified one such transcriptional target, Salt- Inducible Kinase 1 (SIK1), which is an enzyme that catalyzes phosphorylation of class II histone deacetylases and allows expression of ..
  12. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
  13. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..Success of this study is expected to have significant impact in the field of islet transplantation treatment for type 1 diabetes. ..
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  15. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
  16. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
  17. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  18. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and phosphorylation of histone-3 as target...
  20. Apoptosis pathways underlying adipogenesis
    Niketa A Patel; Fiscal Year: 2013
    ..By showing that alternative splicing of apoptotic genes modulate differentiation and maturation of pre-adipocytes, the proposed studies will establish a new paradigm for adipogenesis and reveal new targets for treatment of obesity. ..
  21. Neuroprotection in Models of Cerebral Ischemia
    Jun Chen; Fiscal Year: 2013
    ..A positive outcome of the project not only will have a high impact on enhancing our understanding of the basic molecular mechanisms of ischemic neuronal injury but also shed light on ASK1 as a potential therapeutic target for stroke. ..
  22. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  23. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    ..Specifically, a key component of this pathway (PKG) will be studied to understand how inflammation leads to these vascular disorders. ..
  24. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
  25. Targeted Intervention of Breast Oncogenic Pathways
    Said M Sebti; Fiscal Year: 2013
    ..Clinical trials will be performed to evaluate the efficacy of the drug combinations. ..
  26. Role of Intestinal Cell Kinase in the Intestinal Epithelium
    Zheng Fu; Fiscal Year: 2013
  27. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  28. Modulation of Apoptosis in Prostate Cancer
    Khalil Ahmed; Fiscal Year: 2013
    ..Our long term goal is to take this mode of therapy to the level of translation in PC patients. ..
  29. Biochemical Mechanisms of Long-Term Potentiation
    John David Sweatt; Fiscal Year: 2013
    ..We will pursue the following three Specific Aims: 1: To test the hypothesis that the ERK/MSK pathway regulates histone methylation in the hippocampus...
  30. Role of Rho Kinases in Diabetic Nephropathy
    Farhad R Danesh; Fiscal Year: 2013
    ..We propose that inhibition of the RhoA/ROCK pathway holds promise as a novel therapeutic strategy to improve microvascular outcomes in diabetes. ..
  31. Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain
    Michael Aschner; Fiscal Year: 2013
    ..These specific aims hold the promise of delineating common initiator signals for the modulation of MeHg neuroprotection, shedding light on neurotoxic mechanisms and susceptibility associated with exposure to this metal. ..
  32. BUB1 in Chromosomal Instability and Tumorigenesis
    Jan M van Deursen; Fiscal Year: 2013
    ..Knowledge from these efforts could be exploited to devise novel strategies for cancer treatment and prevention in addition to conceptually advancing the fields of mitosis and cancer biology. ..
  33. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2013
    ..Longer term, the knowledge generated by the proposed studies will provide a firmer foundation for future development of new classes of disease-modifying therapeutics and fuller interpretation of disease progression investigations. ..
  34. Enhancement of dendritic cell vaccine efficiency against pancreatic cancer by M--
    QIZHI C YAO; Fiscal Year: 2010
    ..This project is designed to test a central hypothesis that silencing the master immune negative regulator MSK (mitogen- and stress-activated protein kinase) in dendritic cells will allow them to be fully activated by MSLN-VLP ..
  35. IKBKE/IKKE (epsilon) Kinase in Non-small Cell Lung Cancer
    Jin Q Cheng; Fiscal Year: 2013
    Salman Azhar; Fiscal Year: 2013
    ..Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 on SR-BI expression, SR-BI mediated selective CE transport and bile acid and steroid synthesis in liver and ..
  37. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..invasion, survival, apoptosis and oxidative damage) will be evaluated in cultured premalignant oral leukoplakia (MSK-Leuki) cells following exposure to B(a)P, ethanol and estrogen...
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  39. Perturbed cell signaling network and suicide neurobiology
    Yogesh Dwivedi; Fiscal Year: 2013
    ..lead to altered activation of substrates p90 ribosomal S6 kinase (RSK) and mitogen- and stress-activated kinase (MSK) and their mediated transactivation of transcription factors and chromatin remodeling;2) hypoactive ERK1/2 and PI3K ..
  40. Role and Regulation of Sodium, Potasium ATPase in Lung
    Jacob I Sznajder; Fiscal Year: 2013
    ..specific aims: in studies proposed for Specific Aim 1 we will determine whether the salt inducible kinase (SIK) participates in the GPCR mediated Na,K-ATPase upregulation by facilitating the traffic of Na+ pump molecules from ..
  41. In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    Shantanu Sinha; Fiscal Year: 2013
    ..integrated array of imaging techniques will characterize comprehensively, the multi- component musculoskeletal (MSK) architecture and function of the lower leg, in normal, atrophied and at various stages of recuperation in these ..
  42. Integrating Tobacco Treatment into Cancer Care
    Elyse R Park; Fiscal Year: 2013
    ..breast, or prostate cancer (the four most prevalent cancers) at MGH and Memorial Sloan Kettering Cancer Center (MSK) and compare the differential effectiveness of delivering an Intensive Treatment (IT;10 motivational counseling ..
  43. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Musculoskeletal (MSK) disorders represent a broad group of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  44. Dynamic regulation of hepatic SIK1 during fasting and feeding
    Rebecca L Berdeaux; Fiscal Year: 2013 mouse models and cultured hepatocytes implicated a family of AMPK-related kinases called Salt-Inducible Kinases (SIK1-3), in the control of CRTC co-activator function during fasting and re-feeding...
  45. Image Science for the New X-Ray: Taking Dual-Energy CT to Task
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..Application of DE-CT is seen in abdominal (e.g., renal calculi), musculoskeletal (MSK, e.g., arthritis), and neuro (e.g., perfusion) imaging...
  46. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ..Topic, 05-AR-102: Comparative Effectiveness (CE) of Treatments for Chronic Childhood Arthritis and Musculoskeletal (MSK) and Skin Disease...
    Sanjoy K Das; Fiscal Year: 2012
    ..Our previous and preliminary observations suggest that among several such early genes, Bip and Sik-SP are induced by estradiol- 172 (E2) and kepone in the mouse uterus via ER-independent manner as a phase-I ..
  48. Ca2+ Stimulation of MAP Kinase and Neuroplasticity
    Daniel R Storm; Fiscal Year: 2013
    ..We also discovered that MAPK, PKA, and MSK-1, a CREB kinase, are coactivated in the same subset of neurons in the area CA1 of the hippocampus during memory ..
  49. Memory Enhancement by A Genetic Increase in cAMP Signals
    Daniel R Storm; Fiscal Year: 2013
    ..that the stronger memory exhibited by young AC1+ mice may be due to enhanced signaling through the cAMP/MAPK/ MSK-1/CREB signaling pathway as well as amplification of the circadian oscillation of this pathway...
  50. Reversing genetically modified T cell suppression in a model of liver metastases
    Steven C Katz; Fiscal Year: 2013
    ..I spent two years as a research fellow with Dr. Ronald DeMatteo at Memorial Sloan-Kettering (MSK), where I gained valuable experience in immunologic research and published papers on liver immune cells in ..
    Larry Jenkins; Fiscal Year: 2000
  52. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..3) Perform clinical system performance evaluation trial on human subjects in joint arthrography, MSK biopsy (sarcoma), vertebral biopsy, and disk space aspiration procedures...
  53. The TCGA Cancer Genome Characterization Center at MSKCC
    Marc Ladanyi; Fiscal Year: 2009
    The TCGA Cancer Genome Characterization Center at MSKCC (designated herein MSK-CGCC) will provide comprehensive profiling of gene expression (whole transcript, exon-level, and microRNA) and of genomic gains and losses (whole genome, and ..
    Michelle Pietzak; Fiscal Year: 2003
    ..Under the mentorship of Kwang Sik Kim M.D., Dr...
  55. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    ..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
  56. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
  57. Early Detection of Premalignant Lesions in Oral Cancer
    Keiko Watanabe; Fiscal Year: 2010
    ..The non-receptor protein tyrosine kinase BRK/Sik is an epithelial cell specific kinase that is involved in activation of cellular proliferation, differentiation and ..
    Fouad Kandeel; Fiscal Year: 2006
    ..overall objective of this research application is to establish clinical protocols for simultaneous islet-kidney (SIK) transplantation in type 1 diabetic recipients that will provide long-term euglycemia and insulin-independence...
  59. Role of PID Kinase in Auxin Regulation
    Sioux Christensen; Fiscal Year: 2006
    ..abstract_text> ..
  60. Molecular mechanisms of synapse lose by polo kinases
    Daniel T Pak; Fiscal Year: 2010
    ..abstract_text> ..
    Michael McDaniel; Fiscal Year: 2007
    ..abstract_text> ..
  62. BRK/Sik Tyrosine Kinase Signaling in the Prostate
    ANGELA TYNER; Fiscal Year: 2009
    The intracellular epithelial-specific tyrosine kinase BRK/Sik belongs to a tyrosine kinase family whose members have growth inhibitory functions...
  63. IP3 Receptor Phosphorylation by Akt Kinase
    Suresh Joseph; Fiscal Year: 2006
    ..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..