Gene Symbol: SIK1
Description: salt-inducible kinase 1
Alias: EIEE30, MSK, SIK, SNF1LK, SIK-1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible protein kinase 1, serine/threonine protein kinase, serine/threonine-protein kinase SIK1, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Species: human

Top Publications

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  2. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  3. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
  4. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
  5. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
  7. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001

Detail Information

Publications245 found, 100 shown here

  1. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  2. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
  3. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  4. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
    ..Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features ..
  5. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
    ..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
  6. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  7. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
    ..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
  8. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  9. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  10. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001
  11. ncbi [Cardiac, respiratory and sleep disorders in patients with myotonic dystrophy]
    Marta Banach
    Pracownia EMG, Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie
    Przegl Lek 66:1065-8. 2009
    ..This paper is aimed at characterizing some common cardiologic and sleep related respiratory disorders of patients with myotonic dystrophy which if not recognized in good time may lead to sudden death...
  12. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  13. ncbi Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disorders
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 31:274-9. 2004
  14. ncbi Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
    J H Stack
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
    J Biol Chem 269:31552-62. 1994
    ..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
  15. ncbi Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
    M S Schwab
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
    Curr Biol 11:141-50. 2001
    ..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
  16. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    ..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
  17. ncbi Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  18. ncbi The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes
    P Brunovskis
    Department of Microbiology, Michigan State University, East Lansing 48824 1101
    Virology 206:324-38. 1995
    ..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
  19. pmc Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
    Liliana Endo-Munoz
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Virol J 2:17. 2005
    ..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
  20. ncbi The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domains
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Theor Appl Genet 113:1147-58. 2006
    ..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
  21. ncbi A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
    Eur J Biochem 267:3744-52. 2000
    ..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
  22. ncbi Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
    P Komalavilas
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 274:34301-9. 1999
    ..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
  23. doi Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
    Julie C Fanburg-Smith
    Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 14:8-14. 2010
    ..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
  24. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  25. ncbi Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
    S Sturany
    Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
    J Biol Chem 276:3310-8. 2001
    We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene...
  26. ncbi Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  27. ncbi Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
    Norbert Nagy
    FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
    J Mol Cell Cardiol 42:981-90. 2007
    ..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
  28. ncbi The HIV Dementia Scale: predictive power in mild dementia and HAART
    Kara Anne Bottiggi
    Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
    J Neurol Sci 260:11-5. 2007
    ..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
  29. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  30. ncbi Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children
    Victoria A Cukiernik
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 41:1368-74. 2007
    Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
  31. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
  32. ncbi On the physiological role of casein kinase II in Saccharomyces cerevisiae
    C V Glover
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Prog Nucleic Acid Res Mol Biol 59:95-133. 1998
  33. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  34. pmc Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    M K Webster
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:2031-40. 1993
  35. ncbi Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney
    T Yagisawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 37:1140-3. 2001
    Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
  36. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
  37. pmc Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
    Eri Sakurai
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Pain 5:74. 2009
    ..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
  38. doi The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro
    Carmen Giefing
    Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
    Microbiology 156:1697-707. 2010
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
  39. ncbi Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s
    G Gambaro
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Kidney Int 69:663-70. 2006
    ..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
  40. doi The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis
    Cristina Purcarea
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
    Mol Cell Biochem 311:199-213. 2008
    ..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
  41. ncbi Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A
    Harold I Calvin
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Curr Eye Res 27:269-78. 2003
    ..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
  42. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  43. doi [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]
    M Streibelt
    Charite Universitatsmedizin Berlin
    Rehabilitation (Stuttg) 48:135-44. 2009
    ..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
  44. doi Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
  45. ncbi [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]
    Li jun Zhao
    Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009
    ..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
  46. ncbi Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspective
    Brian J Krabak
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Phys Med Rehabil 86:493-8. 2007
    ..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
  47. ncbi Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
    J Rheumatol 32:1341-8. 2005
    ..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
  48. doi Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model
    Vaijayanti Lagu Joshi
    Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
    J Rheumatol 36:614-22. 2009
    To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
  49. ncbi A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings
    J A Forster
    Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
    Urol Int 78:264-9. 2007
    Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
  50. ncbi Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
    P C Scacheri
    National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Genesis 30:259-63. 2001
    ..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
  51. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
  52. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
  53. ncbi Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  54. ncbi The physical association of casein kinase 2 with nucleolin
    D Li
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:15662-8. 1996
    ..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
  55. ncbi Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain
    K Nara
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Eur J Biochem 268:2642-51. 2001
    ..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
  56. doi SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo
    JinYoung Park
    Department of Life Sciences, Korea University, Seoul, Korea Division of Biochemistry and Molecular Biology, Department of Molecular Cell Biology and Samsung Biomedical Institute, Sungkyunkwan University School of Medicine, Gyeonggi Do, Korea
    Diabetes 63:3659-73. 2014 elaborate whether CREB-regulated transcription factor (CRTC)2 and its negative regulator salt-inducible kinase (SIK)2 are involved in the transcriptional control of the metabolic pathway in adipocytes...
  57. pmc Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy
    Robert Torka
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany Electronic address
    Neoplasia 16:301-18. 2014
    ..Therefore, we conclude that, in patient cohorts with expression of Axl and low basal activity of AKT, a combined inhibition of Axl and HER2/3 kinase would be beneficial to overcome acquired resistance to Axl-targeted therapies. ..
  58. pmc Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    M Delcommenne
    British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
    Proc Natl Acad Sci U S A 95:11211-6. 1998
    ..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
  59. ncbi ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour
    D H Chung
    Department of Pathology, Seoul National University College of Medicine, Korea
    Virchows Arch 433:113-7. 1998
    ..ILK may be a sensitive and specific immunohistochemical marker and useful for the positive identification of ES and PNET in formalin-fixed, paraffin-embedded tissue sections...
  60. doi The selectivity of inhibitors of protein kinase CK2: an update
    Mario A Pagano
    Department of Biological Chemistry and CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Biochem J 415:353-65. 2008
  61. ncbi Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma
    Hideyuki Abe
    Department of Urology, Dokkyo Medical University, Tochigi, Japan
    Biomed Res 29:155-61. 2008
    ..Our findings implicate the RhoC/ROCK pathway in carcinogenesis and progression of RCC, indicating that RhoC/ROCK may be a useful prognostic marker and a possible molecular target for treatment of the disease...
  62. pmc Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis
    Hicham Zegzouti
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:6404-9. 2006
    ..These results indicate that AtPDK1 is a potent enhancer of PID activity and provide evidence that phospholipid signaling may play a role in the signaling processes controlling polar auxin transport...
  63. doi SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury
    M Ferrandi
    Prassis sigma tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, Italy, Division of Genetics and Cell Biology, Genomics of Renal Diseases and Hypertension Unit
    Hum Mol Genet 23:4371-82. 2014
    ..Recently, the salt-inducible kinase 1 (SIK1) has been shown to exert a permissive role on mutant α-adducin effects on renal Na-K ATPase activity involved in ..
  64. doi Protective and toxic roles of dopamine in Parkinson's disease
    Juan Segura-Aguilar
    Faculty of Medicine, Molecular and Clinical Pharmacology, ICBM, University of Chile, Santiago, Chile
    J Neurochem 129:898-915. 2014
  65. pmc mTOR: dissecting regulation and mechanism of action to understand human disease
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK
    Biochem Soc Trans 37:213-6. 2009
  66. pmc A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
    Cory M Johannessen
    1 The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA 2 Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA 3 Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA
    Nature 504:138-42. 2013
    ..Collectively, these data suggest that oncogenic dysregulation of a melanocyte lineage dependency can cause resistance to RAF-MEK-ERK inhibition, which may be overcome by combining signalling- and chromatin-directed therapeutics. ..
  67. ncbi Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast
    T de los Santos
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    J Biol Chem 274:1783-90. 1999
    ..Thus, MEK1-dependent phosphorylation of Red1p facilitates the formation of Hop1p/Red1p hetero-oligomers, thereby enabling the formation of functional AEs...
  68. ncbi Is musculoskeletal history and examination so different in paediatrics?
    Helen E Foster
    Musculoskeletal Research Group, Medical School, University of Newcastle, Framlington Place, Catherine Cookson Building, NE2 4HH Newcastle, UK
    Best Pract Res Clin Rheumatol 20:241-62. 2006
    Musculoskeletal (MSK) complaints in children and adolescents are common. The differential diagnosis is broad and based predominantly on clinical assessment...
  69. ncbi Rates and predictors of herpes zoster in patients with rheumatoid arthritis and non-inflammatory musculoskeletal disorders
    F Wolfe
    National Data Bank for Rheumatic Diseases, Arthritis Research Center Foundation, 1035 N Emporia, Suite 230 Wichita, KS 67214, USA
    Rheumatology (Oxford) 45:1370-5. 2006
    ..We examined its rate and predictors in rheumatoid arthritis (RA) and non-inflammatory musculoskeletal (MSK) disorders to determine if HZ was increased in RA and whether treatment contributed to the risk of HZ.
  70. ncbi Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
    Yasushi Kojima
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:23532-40. 2007
    ..These results indicate that LKB1 is involved in the regulation of microtubule dynamics through the activation of MARKs...
  71. ncbi Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system
    Cristina Lavini
    Department of Radiology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Magn Reson Imaging 25:604-12. 2007
    ..enhanced (DCE) MRI is a widespread method that has found broad application in the imaging of the musculoskeletal (MSK) system...
  72. ncbi A putative serine/threonine protein kinase gene on chromosome III of Saccharomyces cerevisiae
    C Wilson
    Department of Cellular and Developmental Biology, University of Rome La Sapienza, Italy
    Yeast 8:71-7. 1992
    ..Reduced stringency hybridizations revealed the presence of another genomic sequence with high homology to the carboxy-terminal catalytic domain of KIN82...
  73. pmc Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt
    Min Zeng
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 25:3954-61. 2014
    ..Taken together, our findings reveal LanCL2 as a novel regulator of Akt and suggest that LanCL2 facilitates optimal phosphorylation of Akt by mTORC2 via direct physical interactions with both the kinase and the substrate. ..
  74. pmc The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins
    T G Lee
    Department of Microbiology, School of Medicine, University of Washington, Seattle 98195
    Mol Cell Biol 14:2331-42. 1994
  75. ncbi SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
    Rebecca Berdeaux
    Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Med 13:597-603. 2007
    ..Class II HDAC phosphorylation was decreased in M-ACREB myofibers due to a reduction in amounts of Snf1lk (encoding salt inducible kinase, SIK1), a CREB target gene that functions as a class II HDAC kinase...
  76. ncbi Cytoplasmic/nuclear localization of tuberin in different cell lines
    M Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 33:575-9. 2007
    ..Akt also regulates the cytoplasmic/nuclear localization of the cyclin-dependent kinase inhibitor p27. In this study the localization of these two Akt-regulated proteins was analysed in different cell lines...
  77. ncbi Characterization of reproduction-specific genes in a marine bivalve mollusc: influence of maturation stage and sex on mRNA expression
    Isabelle Boutet
    Laboratoire des Sciences de l Environnement Marin, Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, Place Nicolas Copernic, Plouzane, France
    Gene 407:130-8. 2008
    ..This is the first time that the expression of specific genes involved in reproduction mechanisms in a marine mollusc has been described at the molecular level...
  78. ncbi The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1
    T F Franke
    Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 9:141-8. 1994
    ..The high degree of homology between the catalytic domains of Dkt1 and the three known members of the Drosophila PKC family suggests an evolutionarily conserved functional relationship between the members of the two families...
  79. ncbi Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I
    R Jakobi
    Department of Biochemistry, University of California, Riverside 92521, USA
    J Biol Chem 271:6206-11. 1996
    ..A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T., and Gutkind, J. S. (1995) Cell 81, 1137-1146; Minden, A., Lin, A., Claret, F.-X., Abo, A., and Karin, M. (1995) Cell 81, 1147-1157)...
  80. pmc Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation
    Federica Mezzabotta
    Laboratory of Histomorphology and Molecular Biology of the Kidney, Nephrology Division, Department of Medicine DIMED, University of Padua, Padua, Italy
    J Cell Mol Med 19:889-902. 2015
    Medullary nephrocalcinosis is a hallmark of medullary sponge kidney (MSK). We had the opportunity to study a spontaneous calcification process in vitro by utilizing the renal cells of a patient with MSK who was heterozygous for the c...
  81. ncbi Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer
    Carmen Blanco-Aparicio
    Experimental Therapeutics Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Carcinogenesis 28:584-94. 2007
    ..Thus, our model might provide a preclinical relevant model system to study the role of AKT and ERalpha in breast tumorigenesis and the response of mammary gland tumors to chemotherapeutics...
  82. pmc A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners
    Zhiyong Ding
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 950, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:15014-9. 2006
    ..Thus, ACTN4 is a critical regulator of AKT1 localization and function...
  83. doi Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions
    Dana Ferraris
    John Hopkins University Brain Science Institute, 855 North Wolfe Street, Baltimore, MD 21205, USA
    Future Med Chem 5:1923-34. 2013
    ..Several series of ATP-binding site inhibitors have been identified through profiling efforts providing launch points for future medicinal chemistry programs. ..
  84. ncbi A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth
    H Iwamoto
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Hepatol 32:762-70. 2000
    ..The aim of this study was to investigate the mechanism of action of a p160ROCK-specific inhibitor, Y-27632, on cultured rat HSC...
  85. doi Trametinib for the treatment of melanoma
    N Alluri
    Division of Hematology and Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA
    Drugs Today (Barc) 49:491-8. 2013
    ..Preclinical data and limited clinical data suggest that MEK inhibitors may be a component of effective therapy for a broad spectrum of cancers with other oncogenic drivers. ..
  86. ncbi Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1
    Chantal Melchior
    Laboratoire Franco Luxembourgeois de Recherche Biomédicale, CNRS CRP Santé, University Center, 162A, avenue de la Faiencerie L 1511, Luxembourg, Luxembourg
    Biochim Biophys Acta 1575:117-22. 2002
    ..The promoter activity was characterized by a luciferase reporter assay and the minimal sequence conferring promoter activity was 349 bp in size and located immediately upstream of exon 1...
  87. doi Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver
    Tatsuya Uebi
    National Institute of Biomedical Innovation, Osaka, Japan
    Am J Physiol Endocrinol Metab 299:E413-25. 2010
    ..TORC2 was constitutively localized in the nucleus, but its coactivator activity was normally suppressed by SIK1 in COS-7 cells...
  88. ncbi Characterization of PDK2 activity against protein kinase B gamma
    Conrad P Hodgkinson
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biochemistry 41:10351-9. 2002
  89. ncbi A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Francis Ka Ming Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:51613-21. 2003
    ..Thus, TNF-induced programmed necrosis is facilitated by TNFR-2 signaling and caspase inhibition and may play a role in controlling viral infection...
  90. pmc RANKL is a downstream mediator for insulin-induced osteoblastic differentiation of vascular smooth muscle cells
    Ling Qing Yuan
    Institute of Metabolism and Endocrinology, Second Xiang Ya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    PLoS ONE 6:e29037. 2011
    ..These data demonstrated that insulin could promote osteoblastic differentiation of CVSMCs by increased RANKL expression through ERK1/2 activation, but not PI3K/Akt activation...
  91. doi Activation of mammalian target of rapamycin signaling in spatial learning
    Sihua Qi
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 68:88-93. 2010
    ..Thus, mTOR signaling is activated during learning, enhances translation, and plays a crucial role in the spatial learning...
  92. doi Mechanisms of protein kinase A anchoring
    Philipp Skroblin
    Leibniz Institute for Molecular Pharmacology, Berlin, Germany
    Int Rev Cell Mol Biol 283:235-330. 2010
    ..In addition, alternative PKA anchoring mechanisms employed by noncanonical AKAPs and PKA catalytic subunit-interacting proteins are illustrated...
  93. pmc A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
    Morten Frodin
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    EMBO J 21:5396-407. 2002
    The growth factor-activated AGC protein kinases RSK, S6K, PKB, MSK and SGK are activated by serine/threonine phosphorylation in the activation loop and in the hydrophobic motif, C-terminal to the kinase domain...
  94. doi The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases
    Celine Forzani
    Max Perutz Laboratories, Vienna, Austria
    FEBS J 278:1126-36. 2011
    ..In addition, PTI1-4 and MPK6 were found in vivo in the same protein complex. These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades...
  95. doi Serine/threonine protein kinase PrkA of the human pathogen Listeria monocytogenes: biochemical characterization and identification of interacting partners through proteomic approaches
    Analia Lima
    Institut Pasteur de Montevideo Instituto de Investigaciones Biológicas Clemente Estable, Unidad de Bioquímica y Proteómica Analíticas, Uruguay
    J Proteomics 74:1720-34. 2011
    ..Our results suggest that PrkA could be involved in the regulation of a variety of fundamental biological processes...
  96. doi Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1
    Fernando Cardona
    Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Valencia, Spain
    Hum Mutat 32:369-78. 2011
    ..In addition, we have modeled the three-dimensional structure of PINK1 and found some evidences that help to explain the effect of some PD-related mutations in this protein's function...
  97. doi Musculoskeletal examination teaching by patients versus physicians: how are they different? Neither better nor worse, but complementary
    Anna E Oswald
    Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada
    Med Teach 33:e227-35. 2011
    Musculoskeletal (MSK) complaints comprise 12-20% of primary healthcare; however, practicing physicians' MSK physical examination (PE) skills are weak. Further, there is a shortage of specialists able to effectively teach this subject...
  98. pmc Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis
    Arash Mohebati
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Prev Res (Phila) 5:593-602. 2012
    ..Treatment of cell lines derived from oral leukoplakia (MSK-Leuk1) and skin (HaCaT) with benzo[a]pyrene (B[a]P), a prototypic PAH, induced CYP1A1 and CYP1B1 transcription, ..
  99. doi Vemurafenib for the treatment of melanoma
    Emmet John Jordan
    Waterford Regional Hospital, Department of Medical Oncology, Dunmore Road, Waterford, Ireland
    Expert Opin Pharmacother 13:2533-43. 2012
  100. ncbi Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN
    Mikiko Takahashi
    Biosignal Research Center and Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    J Biochem 133:181-7. 2003
    ..These results suggest that PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway...
  101. ncbi Mutations in the human LKB1/STK11 gene
    Virpi Launonen
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Hum Mutat 26:291-7. 2005
    ..However, the proportion of the missense mutations seems to be higher among the somatic mutations (45%) than among the germline mutations (21%), and only seven of the mutations are exactly the same in both of the mutation types...

Research Grants63

  1. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
  2. LKB1- AMPK pathway regulation of glucose metabolism and metformin action in liver
    REUBEN JAMES SHAW; Fiscal Year: 2013
    ..In Aim 1, the role of AMPKalpha1, AMPKalpha2, and the related SIK kinases will be compared in control of hepatic glucose metabolism using novel temporally controlled genetic mouse ..
  3. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  4. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
    ..which in turn causes phenotypic changes, and if inhibition of MSK1 by its chemical inhibitor and shRNA or using a MSK KO mouse blocks alcohol-induced cell transformation and Pol III gene transcription;2) if alcohol-induced H3ph ..
  5. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  6. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    ..In addition, drugs that decrease SK2-associated CK2 activity and thereby decrease neuronal excitability may be therapeutic avenues for treatments of hyperexcitability disorders such as schizophrenia and epilepsy. ..
  7. mTOR, a new target for opioid-induced tolerance and hyperalgesia
    Myron Yaster; Fiscal Year: 2013
    ..Because mTOR inhibitors are FDA-approved drugs, our studies may also have a strong potential clinical application in treating and/or preventing opioid-induced analgesic tolerance and hyperalgesia. ..
  8. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..abstract_text> ..
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  10. Evaluation of the in vivo effects of genes regulating Ataxin1 levels in SCA1 mice
    Qiumin Tan; Fiscal Year: 2013
    ..In Aim 1, I will study the role of MSK paralogs in SCA1 pathogenesis by performing genetic studies of Msk1 and Msk2, in the SCA1 mouse model and ..
  11. The role of SIK1 in myogenic differentiation and skeletal muscle repair
    Rebecca L Berdeaux; Fiscal Year: 2013
    ..We identified one such transcriptional target, Salt- Inducible Kinase 1 (SIK1), which is an enzyme that catalyzes phosphorylation of class II histone deacetylases and allows expression of ..
  12. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..Evidence from our laboratory suggests that AKT serine threonine protein kinase mediates significant functions in the regulation of erythroid cell division and maturation downstream ..
  13. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..Success of this study is expected to have significant impact in the field of islet transplantation treatment for type 1 diabetes. ..
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  15. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
  16. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
  17. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  18. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and phosphorylation of histone-3 as target...
  20. Apoptosis pathways underlying adipogenesis
    Niketa A Patel; Fiscal Year: 2013
    ..By showing that alternative splicing of apoptotic genes modulate differentiation and maturation of pre-adipocytes, the proposed studies will establish a new paradigm for adipogenesis and reveal new targets for treatment of obesity. ..
  21. Neuroprotection in Models of Cerebral Ischemia
    Jun Chen; Fiscal Year: 2013
    ..A positive outcome of the project not only will have a high impact on enhancing our understanding of the basic molecular mechanisms of ischemic neuronal injury but also shed light on ASK1 as a potential therapeutic target for stroke. ..
  22. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  23. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    ..Specifically, a key component of this pathway (PKG) will be studied to understand how inflammation leads to these vascular disorders. ..
  24. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
  25. Targeted Intervention of Breast Oncogenic Pathways
    Said M Sebti; Fiscal Year: 2013
    ..Clinical trials will be performed to evaluate the efficacy of the drug combinations. ..
  26. Role of Intestinal Cell Kinase in the Intestinal Epithelium
    Zheng Fu; Fiscal Year: 2013
  27. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  28. Modulation of Apoptosis in Prostate Cancer
    Khalil Ahmed; Fiscal Year: 2013
    ..Our long term goal is to take this mode of therapy to the level of translation in PC patients. ..
  29. Biochemical Mechanisms of Long-Term Potentiation
    John David Sweatt; Fiscal Year: 2013
    ..We will pursue the following three Specific Aims: 1: To test the hypothesis that the ERK/MSK pathway regulates histone methylation in the hippocampus...
  30. Role of Rho Kinases in Diabetic Nephropathy
    Farhad R Danesh; Fiscal Year: 2013
    ..We propose that inhibition of the RhoA/ROCK pathway holds promise as a novel therapeutic strategy to improve microvascular outcomes in diabetes. ..
  31. Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain
    Michael Aschner; Fiscal Year: 2013
    ..These specific aims hold the promise of delineating common initiator signals for the modulation of MeHg neuroprotection, shedding light on neurotoxic mechanisms and susceptibility associated with exposure to this metal. ..
  32. BUB1 in Chromosomal Instability and Tumorigenesis
    Jan M van Deursen; Fiscal Year: 2013
    ..Knowledge from these efforts could be exploited to devise novel strategies for cancer treatment and prevention in addition to conceptually advancing the fields of mitosis and cancer biology. ..
  33. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2013
    ..Longer term, the knowledge generated by the proposed studies will provide a firmer foundation for future development of new classes of disease-modifying therapeutics and fuller interpretation of disease progression investigations. ..
  34. Enhancement of dendritic cell vaccine efficiency against pancreatic cancer by M--
    QIZHI C YAO; Fiscal Year: 2010
    ..This project is designed to test a central hypothesis that silencing the master immune negative regulator MSK (mitogen- and stress-activated protein kinase) in dendritic cells will allow them to be fully activated by MSLN-VLP ..
  35. IKBKE/IKKE (epsilon) Kinase in Non-small Cell Lung Cancer
    Jin Q Cheng; Fiscal Year: 2013
    Salman Azhar; Fiscal Year: 2013
    ..Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 on SR-BI expression, SR-BI mediated selective CE transport and bile acid and steroid synthesis in liver and ..
  37. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..invasion, survival, apoptosis and oxidative damage) will be evaluated in cultured premalignant oral leukoplakia (MSK-Leuki) cells following exposure to B(a)P, ethanol and estrogen...
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  39. Perturbed cell signaling network and suicide neurobiology
    Yogesh Dwivedi; Fiscal Year: 2013
    ..lead to altered activation of substrates p90 ribosomal S6 kinase (RSK) and mitogen- and stress-activated kinase (MSK) and their mediated transactivation of transcription factors and chromatin remodeling;2) hypoactive ERK1/2 and PI3K ..
  40. Role and Regulation of Sodium, Potasium ATPase in Lung
    Jacob I Sznajder; Fiscal Year: 2013
    ..specific aims: in studies proposed for Specific Aim 1 we will determine whether the salt inducible kinase (SIK) participates in the GPCR mediated Na,K-ATPase upregulation by facilitating the traffic of Na+ pump molecules from ..
  41. In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    Shantanu Sinha; Fiscal Year: 2013
    ..integrated array of imaging techniques will characterize comprehensively, the multi- component musculoskeletal (MSK) architecture and function of the lower leg, in normal, atrophied and at various stages of recuperation in these ..
  42. Integrating Tobacco Treatment into Cancer Care
    Elyse R Park; Fiscal Year: 2013
    ..breast, or prostate cancer (the four most prevalent cancers) at MGH and Memorial Sloan Kettering Cancer Center (MSK) and compare the differential effectiveness of delivering an Intensive Treatment (IT;10 motivational counseling ..
  43. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Musculoskeletal (MSK) disorders represent a broad group of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  44. Dynamic regulation of hepatic SIK1 during fasting and feeding
    Rebecca L Berdeaux; Fiscal Year: 2013 mouse models and cultured hepatocytes implicated a family of AMPK-related kinases called Salt-Inducible Kinases (SIK1-3), in the control of CRTC co-activator function during fasting and re-feeding...
  45. Image Science for the New X-Ray: Taking Dual-Energy CT to Task
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..Application of DE-CT is seen in abdominal (e.g., renal calculi), musculoskeletal (MSK, e.g., arthritis), and neuro (e.g., perfusion) imaging...
  46. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ..Topic, 05-AR-102: Comparative Effectiveness (CE) of Treatments for Chronic Childhood Arthritis and Musculoskeletal (MSK) and Skin Disease...
    Sanjoy K Das; Fiscal Year: 2012
    ..Our previous and preliminary observations suggest that among several such early genes, Bip and Sik-SP are induced by estradiol- 172 (E2) and kepone in the mouse uterus via ER-independent manner as a phase-I ..
  48. Ca2+ Stimulation of MAP Kinase and Neuroplasticity
    Daniel R Storm; Fiscal Year: 2013
    ..We also discovered that MAPK, PKA, and MSK-1, a CREB kinase, are coactivated in the same subset of neurons in the area CA1 of the hippocampus during memory ..
  49. Memory Enhancement by A Genetic Increase in cAMP Signals
    Daniel R Storm; Fiscal Year: 2013
    ..that the stronger memory exhibited by young AC1+ mice may be due to enhanced signaling through the cAMP/MAPK/ MSK-1/CREB signaling pathway as well as amplification of the circadian oscillation of this pathway...
  50. Reversing genetically modified T cell suppression in a model of liver metastases
    Steven C Katz; Fiscal Year: 2013
    ..I spent two years as a research fellow with Dr. Ronald DeMatteo at Memorial Sloan-Kettering (MSK), where I gained valuable experience in immunologic research and published papers on liver immune cells in ..
    Larry Jenkins; Fiscal Year: 2000
  52. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..3) Perform clinical system performance evaluation trial on human subjects in joint arthrography, MSK biopsy (sarcoma), vertebral biopsy, and disk space aspiration procedures...
  53. The TCGA Cancer Genome Characterization Center at MSKCC
    Marc Ladanyi; Fiscal Year: 2009
    The TCGA Cancer Genome Characterization Center at MSKCC (designated herein MSK-CGCC) will provide comprehensive profiling of gene expression (whole transcript, exon-level, and microRNA) and of genomic gains and losses (whole genome, and ..
    Michelle Pietzak; Fiscal Year: 2003
    ..Under the mentorship of Kwang Sik Kim M.D., Dr...
  55. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    ..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
  56. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
  57. Early Detection of Premalignant Lesions in Oral Cancer
    Keiko Watanabe; Fiscal Year: 2010
    ..The non-receptor protein tyrosine kinase BRK/Sik is an epithelial cell specific kinase that is involved in activation of cellular proliferation, differentiation and ..
    Fouad Kandeel; Fiscal Year: 2006
    ..overall objective of this research application is to establish clinical protocols for simultaneous islet-kidney (SIK) transplantation in type 1 diabetic recipients that will provide long-term euglycemia and insulin-independence...
  59. Role of PID Kinase in Auxin Regulation
    Sioux Christensen; Fiscal Year: 2006
    ..abstract_text> ..
  60. Molecular mechanisms of synapse lose by polo kinases
    Daniel T Pak; Fiscal Year: 2010
    ..abstract_text> ..
    Michael McDaniel; Fiscal Year: 2007
    ..abstract_text> ..
  62. BRK/Sik Tyrosine Kinase Signaling in the Prostate
    ANGELA TYNER; Fiscal Year: 2009
    The intracellular epithelial-specific tyrosine kinase BRK/Sik belongs to a tyrosine kinase family whose members have growth inhibitory functions...
  63. IP3 Receptor Phosphorylation by Akt Kinase
    Suresh Joseph; Fiscal Year: 2006
    ..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..