SIK1

Summary

Gene Symbol: SIK1
Description: salt inducible kinase 1
Alias: MSK, SIK, SIK-1, SNF1LK, serine/threonine-protein kinase SIK1, SNF1-like kinase, myocardial SNF1-like kinase, salt-inducible protein kinase 1, serine/threonine-protein kinase SNF1-like kinase 1, serine/threonine-protein kinase SNF1LK
Species: human

Top Publications

  1. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
  2. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
  3. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
  4. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
  5. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
  6. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
  7. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
  8. pmc SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
    Hailing Cheng
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Sci Signal 2:ra35. 2009
  9. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
  10. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994

Research Grants

  1. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
  2. REUBEN JAMES SHAW; Fiscal Year: 2015
  3. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
  4. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
  5. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
  6. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
  7. Yuan Xiang Tao; Fiscal Year: 2016
  8. JoAnn Sekiguchi; Fiscal Year: 2014
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
  10. Qiumin Tan; Fiscal Year: 2015

Detail Information

Publications335 found, 100 shown here

  1. pmc TGFbeta induces SIK to negatively regulate type I receptor kinase signaling
    Marcin Kowanetz
    Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden
    J Cell Biol 182:655-62. 2008
    ..We have identified an inducible gene target of TGFbeta/Smad signaling, the salt-inducible kinase (SIK), which negatively regulates signaling together with Smad7...
  2. pmc LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    Hei Man Vincent Tang
    Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Retrovirology 10:40. 2013
    ..Treatment options are limited and prophylactic agents are not available. We have previously demonstrated an essential role for CREB-regulating transcriptional coactivators (CRTCs) in HTLV-1 transcription...
  3. doi Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity
    Yoshiko Katoh Hashimoto
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka 567 0085, Japan
    J Cell Biochem 104:1724-39. 2008
    ..Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features ..
  4. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..we describe the characterization of two of the genes corresponding to the novel PCR products (designated Hek2 and msk)...
  5. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK...
  6. ncbi 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 118:5661-73. 2005
    ..Interestingly, the 14-3-3 isoforms bound directly to the T-loop Thr residue of QSK and SIK, after these were phosphorylated by LKB1...
  7. ncbi TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    FEBS J 274:3202-9. 2007
    ..In this review, we focus on the basic leucine zipper domain in the regulation of transcriptional activity of CREB and describe the functions of TORC and salt inducible kinase...
  8. pmc SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
    Hailing Cheng
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Sci Signal 2:ra35. 2009
    ..Here, through the use of a kinome-wide loss-of-function screen, we identify the serine-threonine kinase SIK1 (salt-inducible kinase 1) as a regulator of p53-dependent anoikis...
  9. pmc The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:545-55. 2006
    ..Ten of the 14 AMPK-related protein kinases activated by LKB1, including SIK (salt-induced kinase), MARK (microtubule-affinity-regulating kinase) and BRSK (brain-specific kinase) isoforms, ..
  10. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  11. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  12. ncbi Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    D A Cross
    Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
    J Neurochem 77:94-102. 2001
    ....
  13. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  14. ncbi Close association of herpes zoster reactivation and systemic lupus erythematosus (SLE) diagnosis: case-control study of patients with SLE or noninflammatory nusculoskeletal disorders
    Janet E Pope
    Division of Rheumatology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 31:274-9. 2004
    ....
  15. ncbi Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
    J H Stack
    Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla 92093 0668
    J Biol Chem 269:31552-62. 1994
    ..On the basis of the role for Vps34p in vacuolar protein sorting, we propose that the production of a specific phosphoinositide, PtdIns(3)P, is involved in regulating intracellular protein sorting reactions in eukaryotic cells...
  16. ncbi Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
    M S Schwab
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado, School of Medicine, 4200 East Ninth Ave, Denver, CO 80262, USA
    Curr Biol 11:141-50. 2001
    ..However, it is not known whether CSF-dependent metaphase arrest caused by p90(Rsk) involves components of the spindle assembly checkpoint...
  17. ncbi Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    M P Coghlan
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK
    Chem Biol 7:793-803. 2000
    ..This report describes the identification and characterisation of potent and selective small molecule inhibitors of GSK-3...
  18. ncbi Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  19. ncbi The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes
    P Brunovskis
    Department of Microbiology, Michigan State University, East Lansing 48824 1101
    Virology 206:324-38. 1995
    ..Thus, our sequence provides a foundation for further MDV studies aimed at resolving the apparent discrepancy between MDV's genetic and biologic properties...
  20. pmc Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
    Liliana Endo-Munoz
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Virol J 2:17. 2005
    ..Our results showed faster, greater and stronger binding of Tat to TAR RNA after phosphorylation by PKR...
  21. ncbi The barley serine/threonine kinase gene Rpg1 providing resistance to stem rust belongs to a gene family with five other members encoding kinase domains
    R Brueggeman
    Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164 6420, USA
    Theor Appl Genet 113:1147-58. 2006
    ..The genetic mapping, gene structures, and analysis of amino-acid sequences of the Rpg1 gene family members are presented...
  22. ncbi A novel transmembrane serine/threonine protein kinase gene from a rifamycin SV-producing amycolatopsis mediterranei U32
    W Zhang
    Department of Microbiology, Shanghai Institute of Plant Physiology, Academia Sinica, Shanghai, P R China
    Eur J Biochem 267:3744-52. 2000
    ..Although its biological role is still unknown, Amk protein kinase is the first transmembrane serine/threonine protein kinase described for genus Amycolatopsis...
  23. ncbi Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
    P Komalavilas
    Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 274:34301-9. 1999
    ..Increased activation of these MAP kinase pathways may be one mechanism by which cGMP and PKG activation mediate c-fos induction and increased proliferation of contractile adult RASMC...
  24. doi Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
    Julie C Fanburg-Smith
    Department of Orthopaedic and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 14:8-14. 2010
    ..including atypical teratoid tumor in the central nervous system (CNS) and rhabdomyosarcoma in the musculoskeletal (MSK) locations. We reviewed the morphology of CNS and MSK cases and applied a panel of immunostains...
  25. ncbi Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  26. ncbi The HIV Dementia Scale: predictive power in mild dementia and HAART
    Kara Anne Bottiggi
    Graduate Center for Gerontology, College of Public Health, University of Kentucky, KY, USA
    J Neurol Sci 260:11-5. 2007
    ..With the advent of highly active antiretroviral therapy (HAART), the use of sensitive and efficient screening tests for HIV-D continue to be needed for identifying individuals who develop this disorder...
  27. ncbi On the physiological role of casein kinase II in Saccharomyces cerevisiae
    C V Glover
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Prog Nucleic Acid Res Mol Biol 59:95-133. 1998
    ....
  28. ncbi Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation
    K A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:7892-8. 2001
    ..These data suggest a mechanism by which weak PI3-K agonists can regulate S6 phosphorylation and selective translation in the presence of mitogen-activated protein kinase signaling...
  29. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  30. ncbi Naproxen versus acetaminophen for therapy of soft tissue injuries to the ankle in children
    Victoria A Cukiernik
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 41:1368-74. 2007
    Musculoskeletal (MSK) ankle injuries cause significant morbidity in ambulatory pediatric populations. No optimal pharmacotherapy is available.
  31. pmc Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
    M K Webster
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:2031-40. 1993
    ....
  32. ncbi Integrin-linked kinase (ILK): a "hot" therapeutic target
    T N Yoganathan
    Kinetek Pharmaceuticals Inc, Vancouver, BC V6P6P2, Canada
    Biochem Pharmacol 60:1115-9. 2000
    ..A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells. These results indicate that inhibition of ILK may be of significant value in solid tumor therapy...
  33. ncbi Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney
    T Yagisawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 37:1140-3. 2001
    Whether specific metabolic abnormalities are related to nephrolithiasis in patients with medullary sponge kidney (MSK) remains a debated issue...
  34. ncbi Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
    Yoshiko Katoh
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine H 1, Osaka University, Japan
    Eur J Biochem 271:4307-19. 2004
    Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm...
  35. pmc Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
    Eri Sakurai
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Pain 5:74. 2009
    ..In mammals, the CK1 family consists of seven members (alpha, beta, gamma1, gamma2, gamma3, delta, and epsilon) with a highly conserved kinase domain and divergent amino- and carboxy-termini...
  36. ncbi Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease): a Padua Medical School discovery in the 1930s
    G Gambaro
    Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Kidney Int 69:663-70. 2006
    ..clinical diagnostics in the 1930s enabled the discovery of several diseases, including the medullary sponge kidney (MSK)...
  37. doi The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro
    Carmen Giefing
    Intercell AG, Vienna Biocenter 3, A 1030 Vienna, Austria
    Microbiology 156:1697-707. 2010
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus...
  38. doi The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis
    Cristina Purcarea
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201, USA
    Mol Cell Biochem 311:199-213. 2008
    ..The Thr/Ser kinase, its cognate phosphatase and a protein substrate may be elements of a simple signaling pathway, perhaps the most primitive example of this mode of regulation described thus far...
  39. ncbi Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A
    Harold I Calvin
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Curr Eye Res 27:269-78. 2003
    ..To compare the effects of two serine-threonine protein kinase inhibitors in a mouse lens culture system previously designed to investigate cortical cataracts caused by L-buthionine sulfoximine (BSO), inhibitor of GSH biosynthesis...
  40. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  41. doi Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic ..
  42. doi [Validity and reliability of a screening instrument for the identification of extensive work-related problems in patients with chronic diseases (SIMBO-C)]
    M Streibelt
    Charite Universitatsmedizin Berlin
    Rehabilitation (Stuttg) 48:135-44. 2009
    ..Adequate screening instruments do exist, but publications regarding their psychometric quality across indications are still missing...
  43. ncbi Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, United Kingdom
    J Rheumatol 32:1341-8. 2005
    ..To investigate whether chronic widespread pain predicts illness seen in general practice in a 3 year followup period...
  44. ncbi Musculoskeletal education in physical medicine and rehabilitation residency programs: graduating resident perspective
    Brian J Krabak
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Sports Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Phys Med Rehabil 86:493-8. 2007
    ..physical medicine and rehabilitation (PM&R) residents physicians' perceptions of their current musculoskeletal (MSK) training, to identify barriers perceived by resident physicians to improving MSK education experiences, and to ..
  45. ncbi [Effect of gonadotropin-releasing hormone-I agonist and gonadotropin-releasing hormone-II on endometrial carcinoma cell lines with different states of PTEN]
    Li jun Zhao
    Department of Gynecology, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Fu Chan Ke Za Zhi 44:45-9. 2009
    ..To study the effect of gonadotropin-releasing hormone-I (GnRH-I) agonist triptorelin and gonadotropin-releasing hormone-II (GnRH-II) on human endometrial carcinoma with different states of PTEN...
  46. ncbi Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
    P C Scacheri
    National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20892, USA
    Genesis 30:259-63. 2001
    ..exons 2-4 were replaced by a PGK-neomycin cassette inserted in the opposite direction of Men1 transcription (Men1(MSK/+)). Unexpectedly, the Men1 conventional knockout was lethal in heterozygous, chimeric animals...
  47. ncbi A review of the natural progression of medullary sponge kidney and a novel grading system based on intravenous urography findings
    J A Forster
    Department of Urology, Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK
    Urol Int 78:264-9. 2007
    Medullary sponge kidney (MSK) is a developmental abnormality of the medullary pyramids of the kidney, characterised by cystic dilatations of the collecting ducts...
  48. doi Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model
    Vaijayanti Lagu Joshi
    Center for Rheumatic Diseases, CAMP, Pune, 411 001, India
    J Rheumatol 36:614-22. 2009
    To estimate urban prevalence of rheumatic musculoskeletal (MSK) disorders and compare to an earlier rural regional study.
  49. doi Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    Salvatore Piro
    Department of Internal Medicine, University of Catania, Catania 95122, Italy
    Endocrinology 151:4197-206. 2010
    ..Our data support the hypothesis that the chronic elevation of fatty acids contribute to alpha-cell dysregulation frequently observed in type 2 diabetes...
  50. ncbi The physical association of casein kinase 2 with nucleolin
    D Li
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:15662-8. 1996
    ..At present, the physiological significance of the strong interaction between CK2 and nucleolin, an excellent substrate for the enzyme, is not clear. However, this association may be important for regulating rDNA transcription...
  51. ncbi Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain
    K Nara
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Eur J Biochem 268:2642-51. 2001
    ..Fluorescence in situ hybridization analysis was used to map sbk to mouse chromosome 7F1-F3 and rat chromosome 1q21. These data suggest a role for SBK in signal-transduction pathways related to the control of brain development...
  52. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
    ....
  53. ncbi Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  54. pmc Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain
    A M Valverde
    Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 91:8572-6. 1994
    ..PKD may be an unusual component in the transduction of diacylglycerol and phorbol ester signals...
  55. ncbi A casein kinase I activity is constitutively associated with Nck
    G Lussier
    Polypeptide Laboratory, Division of Endocrinology, Department of Medicine, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 272:2688-94. 1997
    ..These results support an in vivo interaction between Nck and CKI-gamma2 and suggest that CKI-gamma2 could be involved in signaling pathways downstream of RTKs...
  56. ncbi The ltk gene family encodes novel receptor-like kinases with temporal expression in developing maize endosperm
    Z Li
    Department of Biological Sciences, Lehman College and The Graduate School and University Center, City University of New York, Bronx 10468, USA
    Plant Mol Biol 37:749-61. 1998
    ..These results suggest that members of the ltk gene family mediate signals associated with seed development and maturation...
  57. ncbi Regulation of auxin response by the protein kinase PINOID
    S K Christensen
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 100:469-78. 2000
    ..Constitutive expression of PID causes a phenotype in both shoots and roots that is similar to that of auxin-insensitive plants, implying that PID, which encodes a serine-threonine protein kinase, negatively regulates auxin signaling...
  58. ncbi Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders
    H M Schuller
    Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville 37909 1071, USA
    Eur J Pharmacol 393:265-77. 2000
    ..Similarly, up-regulation of one or several components of this nicotinic receptor pathway in smokers may be an important factor for the development of small cell lung carcinoma...
  59. ncbi Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases
    S Sturany
    Abteilung Innere Medizin I and Institut für Humangenetik, Medizinische Fakultät der Universität, Ulm, Germany
    J Biol Chem 276:3310-8. 2001
    ..Finally, gastrin was found to be a physiological activator of PKD2 in human AGS-B cells stably transfected with the CCK(B)/gastrin receptor. Thus, PKD2 is a novel phorbol ester- and growth factor-stimulated protein kinase...
  60. ncbi Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity
    Constantinos G Broustas
    Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 277:3053-9. 2002
    ..Our studies identify MBS as a new substrate of Raf-1 and implicate a role for Raf-1 in the regulation of pathways involving myosin phosphatase activity...
  61. ncbi Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, Building 36, Room 2C02, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 98:58-66. 2002
    ..These findings suggest that during neurogenesis in the developing cortex, DHEA and DHEAS regulate the survival of neural precursors and progeny through the Akt signaling pathway...
  62. ncbi Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping
    Panayiotis O Vacratsis
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biochemistry 41:5613-24. 2002
    ..Finally, two-dimensional phosphopeptide mapping confirmed that phosphorylation of Ser(555) and Ser(556) of MLK3 is induced by the activated small GTPase Cdc42...
  63. ncbi Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas
    Christopher J Winrow
    The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 14:2671-84. 2005
    ..The combined application of cytogenetic and gene expression approaches identified specific loci and genes that define the pathway of initiation and progression of lymphoreticular malignancies in the absence of ATM...
  64. ncbi TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase
    M Carmen Solaz-Fuster
    Instituto de Biomedicina de Valencia CSIC, Jaime Roig 11, 46010 Valencia, Spain
    Cell Signal 18:1702-12. 2006
    ..We also showed that AMPK was able to phosphorylate in vitro TRIP6 at the N-terminus. Finally, we present evidence that transcriptional co-activator properties of TRIP6 were enhanced by AMPK action...
  65. ncbi Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Gent, Belgium
    Cancer Res 66:4852-62. 2006
    ..Our results in estrogen-unresponsive fibroblasts, mitogen- and stress-activated protein kinase (MSK) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that phytoestrogenic isoflavones can ..
  66. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  67. ncbi Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors
    Shai Gavi
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Endocrinology 148:2653-62. 2007
    ..IGF-I attenuates the ability of beta(1)-adrenergic receptors to accumulate intracellular cAMP in response to Iso and promotes internalization of beta(1)-adrenergic receptors in these cardiac myocytes...
  68. ncbi Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
    Norbert Nagy
    FAHA Cardiovascular Research Center, University of Connecticut School of Medicine Farmington, Cardiovascular Research Institute, CT 06030 1110, USA
    J Mol Cell Cardiol 42:981-90. 2007
    ..Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) ..
  69. pmc Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation
    Camilla Hauge
    Biotech Research and Innovation Centre, Ole Maaløes vej, Copenhagen N, Denmark
    EMBO J 26:2251-61. 2007
    ..the role of the third, so-called turn motif phosphate, also located in the tail, in the AGC kinases PKB, S6K, RSK, MSK, PRK and PKC...
  70. ncbi Molecular cloning and characterization of a putative protein kinase gene from the thermophilic fungus Thermomyces lanuginosus
    Duo Chuan Li
    Department of Environmental Biology, Shandong Agricultural University, Taian, Shandong, People s Republic of China
    DNA Seq 18:423-33. 2007
    ..The putative protein kinase contained three arginine/serine-rich (SR) regions and two transmembrane domains. These showed that it might be a novel putative serine-threonine protein kinase...
  71. ncbi Oxidative burst induced pseudosclerotium formation of Morchella steppicola Zerova on different malt agar media
    I Kiraly
    Department of Plant Physiology and Molecular Plant Biology, Eotvos University, Hungary 1117 Budapest, Pazmany Peter setany 1 C
    Can J Microbiol 53:975-82. 2007
    Morchella steppicola Zerova mycelia was grown on modified MS (MSK) medium and on MSK medium containing different malt content. Starvation induced an enhanced pseudosclerotium formation in a given zone of the culture...
  72. pmc LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    R J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Acta Physiol (Oxf) 196:65-80. 2009
    ..These findings have broad implications for the control of cell growth by nutrients in a number of cellular and organismal contexts...
  73. doi AMPK-dependent hormonal regulation of whole-body energy metabolism
    N L Dzamko
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research and The University of Melbourne, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Acta Physiol (Oxf) 196:115-27. 2009
    ....
  74. pmc Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth
    Catherine E Gleason
    University of Pennsylvania School of Medicine, Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Mol Endocrinol 24:178-92. 2010
    ..This is accentuated during diet-induced obesity, when Igfbp5-deficient mice have increased adiposity compared with wild-type mice on the same diet. These studies reveal a novel role for Igfbp5 in the control of growth and metabolism...
  75. doi Neither K+ channels nor PI3K/Akt mediates the vasodilative effect of nebivolol on different types of rat arteries
    Yan Wang
    Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi Province, People s Republic of China
    J Cardiovasc Pharmacol Ther 14:332-8. 2009
    ..The current study was designed to determine whether K(+) channels or phosphatidylinositol-3-kinase (PI3K)/Akt may affect vasorelaxation induced by nebivolol in different rat arteries...
  76. doi Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK)
    Francesca Forner
    Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Biochim Biophys Acta 1804:1334-41. 2010
    ..We also obtained evidence of a direct interaction of DMPK with alphaB-crystallin/HSPB5 and HSP25/HSPB1...
  77. doi Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins
    Judit Remenyi
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 428:281-91. 2010
    ..of the miR-212/132 miRNA cluster and the miRNAs derived from it are regulated by the ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway, via both MSK (mitogen and stress-activated kinase)-dependent and -independent mechanisms.
  78. doi Prevalence of musculoskeletal pain and rheumatic diseases in the southeastern region of Mexico. A COPCORD-based community survey
    José Alvarez-Nemegyei
    Unidad de Investigación Médica, Unidad Medica de Alta Especialidad, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico
    J Rheumatol Suppl 86:21-5. 2011
    To assess the prevalence of musculoskeletal (MSK) pain and rheumatic diseases in the southeastern Mexican state of Yucatán.
  79. doi Effects of propofol on proliferation and anti-apoptosis of neuroblastoma SH-SY5Y cell line: new insights into neuroprotection
    Gong Jhe Wu
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Brain Res 1384:42-50. 2011
    ..However, further delineation of the precise neuroprotective effects of propofol will need to be examined...
  80. pmc Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays
    Esther Sala
    Grup de Recerca en Nutrigenòmica, Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Campus de Sescelades, Tarragona, Catalonia, Spain
    PLoS ONE 6:e16903. 2011
    ....
  81. ncbi 14-3-3zeta cooperates with phosphorylated Plk1 and is required for correct cytokinesis
    Jian Du
    Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China
    Front Biosci (Schol Ed) 4:639-50. 2012
    ..Taken together with the results of previous studies, our results suggest 14-3-3 family emerges as a novel player in mitotic regulation: cooperation with Plk1 to ensure a faithful cytokinesis...
  82. pmc Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury
    Flaubert Tchantchou
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA
    J Neurotrauma 30:565-79. 2013
    ..This study indicates that the fine-tuning of 2-AG signaling by modulating ABHD6 activity can exert anti-inflammatory and neuroprotective effects in TBI...
  83. doi Fluid shear stress and melatonin in combination activate anabolic proteins in MC3T3-E1 osteoblast cells
    Chi Hyun Kim
    Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, Gangwon Do, Korea
    J Pineal Res 54:453-61. 2013
    ..Therefore, fluid shear stress in combination with melatonin may promote the anabolic response of osteoblasts...
  84. doi Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin
    Yuan Gu
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Anticancer Drugs 24:781-91. 2013
    ..WT tumors in the dorsal skinfold chamber model. Taken together, these results show for the first time an antiangiogenic action of arctigenin, which may contribute considerably toward its antitumor activity. ..
  85. doi Musculoskeletal pain: should physicians test for vitamin D level?
    Khaled Al-Jarallah
    Department of Medicine, Faculty of Medicine, Kuwait University, Jabriya, Kuwait
    Int J Rheum Dis 16:193-7. 2013
    The aim of this study was to evaluate vitamin D levels using a reliable method in patients with regional and generalized musculoskeletal (MSK) pain in comparison to healthy controls.
  86. doi The consequences of long-term glycogen synthase kinase-3 inhibition on normal and insulin resistant rat hearts
    T B Flepisi
    Department of Medicine, Division of Pharmacology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, 7505, South Africa
    Cardiovasc Drugs Ther 27:381-92. 2013
    ..This study aimed to determine whether myocardial GSK-3 protein and its substrate proteins are dysregulated in obesity and insulin resistance, and whether chronic GSK-3 inhibition can prevent or reverse this...
  87. pmc CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
    E Di Pasquale
    Istituto di Ricerca Genetica e Biomedica, National Research Council of Italy, Milan, Italy
    Cell Death Dis 4:e843. 2013
    ....
  88. doi Musculoskeletal training: are GP trainees exposed to the right case mix for independent practice?
    Iain Goff
    Department of Rheumatology, Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, UK
    Clin Rheumatol 35:507-11. 2016
    ..Disorders were classified according to working diagnosis or body region if diagnosis was unclear. Musculoskeletal (MSK) disorders comprised 17 % of consultations, and the distribution of diagnoses of these was in proportion to ..
  89. doi MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD
    Jian Xun Wang
    From the Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China J X W, K W, Y W, S T, L Y Z, Y G, Z X Z, J L, J L W, P f L and State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China X J Z, Q L, J Q J, C F
    Circ Res 117:352-63. 2015
    ..In addition, microRNAs and long noncoding RNAs have been shown to play important roles in various biological processes recently...
  90. doi Evaluation of MRI-US Fusion Technology in Sports-Related Musculoskeletal Injuries
    Manuel Wong-On
    Sports Medicine Fellowship University of Barcelona, Barcelona, Spain
    Adv Ther 32:580-94. 2015
    ..real-time high-resolution ultrasound (US) known as fusion imaging may improve visualization of musculoskeletal (MSK) sports medicine injuries...
  91. doi Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids
    Takeshi Yokoyama
    Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0914, Japan
    J Med Chem 58:7400-8. 2015
    ..The present study provides a better understanding of the molecular properties of the ATP site of DAPK1 and may be useful for the design of specific DAPK1 inhibitors. ..
  92. doi PLK-1 Expression is Associated with Histopathological Response to Neoadjuvant Therapy of Hepatic Metastasis of Colorectal Carcinoma
    M J Fernandez-Acenero
    Department of Surgical Pathology, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040, Madrid, Spain
    Pathol Oncol Res 22:377-83. 2016
    ..This study shows the association between survival and poor histopathological response to therapy and high expression of PLK1 in metastasis. Our results could open a new therapeutic approach through the inhibition of PLK1...
  93. pmc Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    Sci Rep 5:17316. 2015
    ..To this end, erythrocytes were isolated from mice lacking functional MSK1/2 (msk(-/-)) and corresponding wild-type mice (msk(+/+))...
  94. doi Advanced Techniques in Musculoskeletal Oncology: Perfusion, Diffusion, and Spectroscopy
    Pedro A Gondim Teixeira
    Service d Imagerie Guilloz, Hopital Central, CHU Nancy, France
    Semin Musculoskelet Radiol 19:463-74. 2015
    ..Additionally, the application of functional methods in the MSK system has various technical issues that need to be addressed to ensure data quality and comparability...
  95. doi New onset vasomotor symptoms but not musculoskeletal symptoms associate with clinical outcomes on extended adjuvant letrozole - Analyses from NCIC CTG MA.17
    P E R Liedke
    Department of Clinical Oncology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil Mãe de Deus Cancer Institute, Hospital Mae de Deus, Porto Alegre, RS, Brazil Brazilian Breast Cancer Study Group, Porto Alegre, RS, Brazil Massachusetts General Hospital Cancer Center, Avon International Breast Cancer Research Program, Boston, MA, USA
    Breast 27:99-104. 2016
    ..We performed this exploratory analysis of the association of new onset musculoskeletal (MSK) and vasomotor (VM) symptoms with clinical outcomes in the NCIC CTG MA...
  96. pmc Carolacton Treatment Causes Delocalization of the Cell Division Proteins PknB and DivIVa in Streptococcus mutans in vivo
    Michael Reck
    Department of Microbiology, Microbial Communication, Helmholtz Centre for Infection Research Braunschweig, Germany
    Front Microbiol 7:684. 2016
    ..The established vector system represents a novel tool to study essential steps of cellular metabolism. ..
  97. ncbi DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies
    Shan Wang
    Department of Biotherapy Technology Center, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, 510120, China
    Mol Neurobiol . 2016
    ..We hope to provide exhaustive summaries of relevant studies on DAPK1 signals involved in stroke damage. Therefore, disrupting DAPK1-relevant cell death pathway could be considered as a promising therapeutic approach in stroke...
  98. pmc Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice
    Christa Pfeifhofer-Obermair
    Department for Pharmacology and Genetics, Division of Translational Cell Genetics, Peter Mayr Straße 1a, 6020, Innsbruck, Austria
    Cell Commun Signal 14:14. 2016
    ..Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta (-/-)) mice in order to investigate if PKCtheta plays a role in macrophage-mediated immune responses during bacterial infections...
  99. doi c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis
    Fufa Qu
    CAS Key Laboratory of Tropical Marine Bio resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China South China Sea Bio Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510275, China Department of Biological and Environmental Engineering, Changsha University, Changsha 410022, China
    Dev Comp Immunol 67:77-85. 2017
    ..In summary, this study provided the first experimental demonstration that oysters possess a functional JNK that participates in host defense against bacterial infection in C. hongkongensis...
  100. pmc Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages
    Nicola J Darling
    MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dow St, Dundee, DD1 5EH, United Kingdom
    Biochem J . 2016
    ..attractive new drug targets for the treatment of macrophage-driven diseases, but which of the three isoforms, SIK1, SIK2 or SIK3 would be appropriate to target remains unknown...
  101. doi New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation
    Jasmin Roohi
    Clinical Genetics, Kaiser Permanente Mid Atlantic Medical Group, Formerly Division of Clinical Genetics, Department of Pediatrics, Columbia University Medical Center, Rockville, MD, USA
    J Hum Genet . 2017
    ..Journal of Human Genetics advance online publication, 26 January 2017; doi:10.1038/jhg.2017.6...

Research Grants63

  1. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..The results are likely to lead to novel therapeutic strategies for malignant gliomas, particularly;those characterized by high GSTP1 expression and elevated or highly activated PKCs. ..
  2. REUBEN JAMES SHAW; Fiscal Year: 2015
    ..In Aim 1, the role of AMPKalpha1, AMPKalpha2, and the related SIK kinases will be compared in control of hepatic glucose metabolism using novel temporally controlled genetic mouse ..
  3. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..Selected targets will be validated and the effect of their knockdown on virus replication determined. These experiments will uncover additional cell proteins or networks that could be targets for anti-viral therapeutic strategies. ..
  4. Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    Shuping Zhong; Fiscal Year: 2013
    ..which in turn causes phenotypic changes, and if inhibition of MSK1 by its chemical inhibitor and shRNA or using a MSK KO mouse blocks alcohol-induced cell transformation and Pol III gene transcription;2) if alcohol-induced H3ph ..
  5. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..We will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS ..
  6. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    ..In addition, drugs that decrease SK2-associated CK2 activity and thereby decrease neuronal excitability may be therapeutic avenues for treatments of hyperexcitability disorders such as schizophrenia and epilepsy. ..
  7. Yuan Xiang Tao; Fiscal Year: 2016
    ..Because mTOR inhibitors are FDA-approved drugs, our studies may also have a strong potential clinical application in treating and/or preventing opioid-induced analgesic tolerance and hyperalgesia. ..
  8. JoAnn Sekiguchi; Fiscal Year: 2014
    ..abstract_text> ..
  9. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  10. Qiumin Tan; Fiscal Year: 2015
    ..In Aim 1, I will study the role of MSK paralogs in SCA1 pathogenesis by performing genetic studies of Msk1 and Msk2, in the SCA1 mouse model and ..
  11. Rebecca L Berdeaux; Fiscal Year: 2015
    ..We identified one such transcriptional target, Salt- Inducible Kinase 1 (SIK1), which is an enzyme that catalyzes phosphorylation of class II histone deacetylases and allows expression of ..
  12. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    ..Results from these studies will provide critical information on mechanisms of regulation of erythroid cell division and maturation, and should shed light on fundamental aspects of erythropoiesis. ..
  13. Improving islet transplantation outcome with Akt1
    Hongju Wu; Fiscal Year: 2013
    ..Success of this study is expected to have significant impact in the field of islet transplantation treatment for type 1 diabetes. ..
  14. MORRIS JAY BIRNBAUM; Fiscal Year: 2014
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  15. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
  16. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
    ....
  17. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  18. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and phosphorylation of histone-3 as target...
  19. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
  20. Niketa A Patel; Fiscal Year: 2015
    ..By showing that alternative splicing of apoptotic genes modulate differentiation and maturation of pre-adipocytes, the proposed studies will establish a new paradigm for adipogenesis and reveal new targets for treatment of obesity. ..
  21. Jun Chen; Fiscal Year: 2015
    ..A positive outcome of the project not only will have a high impact on enhancing our understanding of the basic molecular mechanisms of ischemic neuronal injury but also shed light on ASK1 as a potential therapeutic target for stroke. ..
  22. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..We will test the hypothesis that AMPK-related kinases SNARK ARK5, SIK1 and MARK4 regulate glucose uptake by using novel techniques including mutagenesis and in vivo gene transfer into ..
  23. Expression of PKG in Vascular Smooth Muscle Cells
    Thomas M Lincoln; Fiscal Year: 2013
    ..Specifically, a key component of this pathway (PKG) will be studied to understand how inflammation leads to these vascular disorders. ..
  24. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
    ....
  25. Said M Sebti; Fiscal Year: 2014
    ..Clinical trials will be performed to evaluate the efficacy of the drug combinations. ..
  26. Role of Intestinal Cell Kinase in the Intestinal Epithelium
    Zheng Fu; Fiscal Year: 2013
    ....
  27. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Successful completion of the proposed investigations will provide novel, efficacious compounds required for clinical development of new therapies for neurological disorders. ..
  28. Khalil Ahmed; Fiscal Year: 2015
    ..Our long term goal is to take this mode of therapy to the level of translation in PC patients. ..
  29. John David Sweatt; Fiscal Year: 2016
    ..We will pursue the following three Specific Aims: 1: To test the hypothesis that the ERK/MSK pathway regulates histone methylation in the hippocampus...
  30. Farhad R Danesh; Fiscal Year: 2016
    ..We propose that inhibition of the RhoA/ROCK pathway holds promise as a novel therapeutic strategy to improve microvascular outcomes in diabetes. ..
  31. Michael Aschner; Fiscal Year: 2016
    ..These specific aims hold the promise of delineating common initiator signals for the modulation of MeHg neuroprotection, shedding light on neurotoxic mechanisms and susceptibility associated with exposure to this metal. ..
  32. Jan M van Deursen; Fiscal Year: 2016
    ..Knowledge from these efforts could be exploited to devise novel strategies for cancer treatment and prevention in addition to conceptually advancing the fields of mitosis and cancer biology. ..
  33. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2013
    ..Longer term, the knowledge generated by the proposed studies will provide a firmer foundation for future development of new classes of disease-modifying therapeutics and fuller interpretation of disease progression investigations. ..
  34. Enhancement of dendritic cell vaccine efficiency against pancreatic cancer by M--
    QIZHI C YAO; Fiscal Year: 2010
    ..This project is designed to test a central hypothesis that silencing the master immune negative regulator MSK (mitogen- and stress-activated protein kinase) in dendritic cells will allow them to be fully activated by MSLN-VLP ..
  35. Jin Q Cheng; Fiscal Year: 2016
    ....
  36. Salman Azhar; Fiscal Year: 2014
    ..Specifically, we propose to determine the stimulatory and inhibitory actions of SF-1/LRH-1 and NHERF1/2 and SIK-1 on SR-BI expression, SR-BI mediated selective CE transport and bile acid and steroid synthesis in liver and ..
  37. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..invasion, survival, apoptosis and oxidative damage) will be evaluated in cultured premalignant oral leukoplakia (MSK-Leuki) cells following exposure to B(a)P, ethanol and estrogen...
  38. COMPLEMENTATION ASSAY TO SCREEN FOR KINASE INHIBITORS
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  39. Yogesh Dwivedi; Fiscal Year: 2016
    ..lead to altered activation of substrates p90 ribosomal S6 kinase (RSK) and mitogen- and stress-activated kinase (MSK) and their mediated transactivation of transcription factors and chromatin remodeling;2) hypoactive ERK1/2 and PI3K ..
  40. Jacob I Sznajder; Fiscal Year: 2016
    ..specific aims: in studies proposed for Specific Aim 1 we will determine whether the salt inducible kinase (SIK) participates in the GPCR mediated Na,K-ATPase upregulation by facilitating the traffic of Na+ pump molecules from ..
  41. Shantanu Sinha; Fiscal Year: 2014
    ..integrated array of imaging techniques will characterize comprehensively, the multi- component musculoskeletal (MSK) architecture and function of the lower leg, in normal, atrophied and at various stages of recuperation in these ..
  42. Elyse R Park; Fiscal Year: 2016
    ..breast, or prostate cancer (the four most prevalent cancers) at MGH and Memorial Sloan Kettering Cancer Center (MSK) and compare the differential effectiveness of delivering an Intensive Treatment (IT;10 motivational counseling ..
  43. Elena Losina; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Musculoskeletal (MSK) disorders represent a broad group of conditions with diverse etiologies that result in pain and functional impairment of bones, joints, tendons, ligaments and/or muscles...
  44. Rebecca L Berdeaux; Fiscal Year: 2015
    ..in mouse models and cultured hepatocytes implicated a family of AMPK-related kinases called Salt-Inducible Kinases (SIK1-3), in the control of CRTC co-activator function during fasting and re-feeding...
  45. Jeffrey H Siewerdsen; Fiscal Year: 2014
    ..Application of DE-CT is seen in abdominal (e.g., renal calculi), musculoskeletal (MSK, e.g., arthritis), and neuro (e.g., perfusion) imaging...
  46. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ANITA NIJHAWAN HAGGSTROM; Fiscal Year: 2010
    ..Topic, 05-AR-102: Comparative Effectiveness (CE) of Treatments for Chronic Childhood Arthritis and Musculoskeletal (MSK) and Skin Disease...
  47. ENVIRONMENTAL TOXINS AND UTERINE GENE EXPRESSION
    Sanjoy K Das; Fiscal Year: 2012
    ..Our previous and preliminary observations suggest that among several such early genes, Bip and Sik-SP are induced by estradiol- 172 (E2) and kepone in the mouse uterus via ER-independent manner as a phase-I ..
  48. Ca2+ Stimulation of MAP Kinase and Neuroplasticity
    Daniel R Storm; Fiscal Year: 2013
    ..We also discovered that MAPK, PKA, and MSK-1, a CREB kinase, are coactivated in the same subset of neurons in the area CA1 of the hippocampus during memory ..
  49. Daniel R Storm; Fiscal Year: 2015
    ..that the stronger memory exhibited by young AC1+ mice may be due to enhanced signaling through the cAMP/MAPK/ MSK-1/CREB signaling pathway as well as amplification of the circadian oscillation of this pathway...
  50. Steven C Katz; Fiscal Year: 2016
    ..I spent two years as a research fellow with Dr. Ronald DeMatteo at Memorial Sloan-Kettering (MSK), where I gained valuable experience in immunologic research and published papers on liver immune cells in ..
  51. HYPOTHERMIA AND TRAUMA
    Larry Jenkins; Fiscal Year: 2000
    ....
  52. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..3) Perform clinical system performance evaluation trial on human subjects in joint arthrography, MSK biopsy (sarcoma), vertebral biopsy, and disk space aspiration procedures...
  53. The TCGA Cancer Genome Characterization Center at MSKCC
    Marc Ladanyi; Fiscal Year: 2009
    The TCGA Cancer Genome Characterization Center at MSKCC (designated herein MSK-CGCC) will provide comprehensive profiling of gene expression (whole transcript, exon-level, and microRNA) and of genomic gains and losses (whole genome, and ..
  54. E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUM
    Michelle Pietzak; Fiscal Year: 2003
    ..Under the mentorship of Kwang Sik Kim M.D., Dr...
  55. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    ..These studies should provide important information about other roles for prolactin in the mammary gland and identify the mechanisms by which prolactin regulates these diverse processes. ..
  56. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  57. Early Detection of Premalignant Lesions in Oral Cancer
    Keiko Watanabe; Fiscal Year: 2010
    ..The non-receptor protein tyrosine kinase BRK/Sik is an epithelial cell specific kinase that is involved in activation of cellular proliferation, differentiation and ..
  58. ISLET-KIDNEY TRANSPLANTATION FOR TYPE I DIABETES
    Fouad Kandeel; Fiscal Year: 2006
    ..overall objective of this research application is to establish clinical protocols for simultaneous islet-kidney (SIK) transplantation in type 1 diabetic recipients that will provide long-term euglycemia and insulin-independence...
  59. Molecular mechanisms of synapse lose by polo kinases
    Daniel T Pak; Fiscal Year: 2010
    ..abstract_text> ..
  60. BRK/Sik Tyrosine Kinase Signaling in the Prostate
    ANGELA TYNER; Fiscal Year: 2009
    The intracellular epithelial-specific tyrosine kinase BRK/Sik belongs to a tyrosine kinase family whose members have growth inhibitory functions...
  61. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael McDaniel; Fiscal Year: 2007
    ..abstract_text> ..
  62. Role of PID Kinase in Auxin Regulation
    Sioux Christensen; Fiscal Year: 2006
    ..abstract_text> ..
  63. IP3 Receptor Phosphorylation by Akt Kinase
    Suresh Joseph; Fiscal Year: 2006
    ..The studies proposed in this application are significant since both signaling systems play important roles in many clinically relevant processes such as insulin and growth factor signaling, angiogenesis and oncogenesis. ..