SHIP2

Summary

Gene Symbol: SHIP2
Description: inositol polyphosphate phosphatase like 1
Alias: OPSMD, SHIP2, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 51C protein, INPPL-1, SH2 domain-containing inositol-5'-phosphatase 2, SHIP-2, protein 51C
Species: human

Top Publications

  1. doi Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes
    Mervi E Hyvönen
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 328:70-9. 2010
  2. pmc Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
    Ji Hee Yun
    Department of Physiology, Ewha Womans University School of Medicine Seoul 158 710, Korea
    Exp Mol Med 43:660-8. 2011
  3. ncbi Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases
    J A Hejna
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Genomics 29:285-7. 1995
  4. ncbi Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 239:697-700. 1997
  5. ncbi Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
    T Habib
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105, USA
    J Biol Chem 273:18605-9. 1998
  6. ncbi The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS Lett 437:301-3. 1998
  7. ncbi A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
    D Wisniewski
    Sloan Kettering Institute for Cancer Research, Molecular Pharmacology and Therapeutics Program and Molecular Biology Program, New York, NY, USA
    Blood 93:2707-20. 1999
  8. pmc SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
    N Prasad
    Department of Cell Biology, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Mol Cell Biol 21:1416-28. 2001
  9. pmc Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity
    T Wada
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Mol Cell Biol 21:1633-46. 2001
  10. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001

Research Grants

  1. Spiro Getsios; Fiscal Year: 2016
  2. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2012
  3. Robert M Lavker; Fiscal Year: 2016
  4. Identification of Signaling Targets of EphA2
    Sonja Schmidt; Fiscal Year: 2005
  5. SEARCH FOR SELECTIVE THERAPY OF CML
    Bayard Clarkson; Fiscal Year: 2007
  6. LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY
    BETH DREES; Fiscal Year: 2002
  7. Indentification of AKT2/aPKC Substrates in Adipocytes
    Prem Sharma; Fiscal Year: 2005
  8. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
  9. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications163 found, 100 shown here

  1. doi Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes
    Mervi E Hyvönen
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 328:70-9. 2010
    ..a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling...
  2. pmc Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
    Ji Hee Yun
    Department of Physiology, Ewha Womans University School of Medicine Seoul 158 710, Korea
    Exp Mol Med 43:660-8. 2011
    ..Our results suggest that caveolin-1 is involved in astrocyte-specific intracellular responses linked to the SHP-2-mediated signaling cascade following ROS-induced oxidative stress...
  3. ncbi Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases
    J A Hejna
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Genomics 29:285-7. 1995
    ..Several polymorphisms have been mapped to the 3'-untranslated region, yet the putative coding region showed no polymorphisms in nine independent cDNA samples...
  4. ncbi Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Belgium
    Biochem Biophys Res Commun 239:697-700. 1997
    ..new SH2-domain-containing protein showing homology to the inositol 5-phosphatase SHIP and therefore referred to as SHIP2. SHIP2 differs at both N- and C-terminal ends with the sequence of INPPL-1...
  5. ncbi Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
    T Habib
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105, USA
    J Biol Chem 273:18605-9. 1998
    Antibodies raised against the 51C/SHIP2 inositol polyphosphate 5'-phosphatase were used to examine the effects of growth factors and insulin on the metabolism of this protein...
  6. ncbi The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity
    X Pesesse
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Brussels, Belgium
    FEBS Lett 437:301-3. 1998
    ..SHIP1 is the 145-kDa SH2 domain-containing inositol 5-phosphatase expressed in haematopoietic cells. SHIP2 is a related but distinct gene product...
  7. ncbi A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
    D Wisniewski
    Sloan Kettering Institute for Cancer Research, Molecular Pharmacology and Therapeutics Program and Molecular Biology Program, New York, NY, USA
    Blood 93:2707-20. 1999
    ..associated with src homologous and collagen gene (SHC) from p210(bcr/abl)-expressing hematopoietic cells as SHIP2, a recently reported, unique SH2-domain-containing protein closely related to phosphatidylinositol polyphosphate 5-..
  8. pmc SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
    N Prasad
    Department of Cell Biology, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Mol Cell Biol 21:1416-28. 2001
    In a previous study, we found that the SHIP2 protein became tyrosine phosphorylated and associated with the Shc adapter protein in response to the treatment of cells with growth factors and insulin (T. Habib, J. A. Hejna, R. E...
  9. pmc Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity
    T Wada
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Mol Cell Biol 21:1633-46. 2001
    ..We recently cloned rat SH2-containing inositol phosphatase 2 (SHIP2) cDNA which possesses the 5'-phosphatase activity to hydrolyze PI(3,4,5)P3 to PI 3,4-bisphosphate [PI(3,4)P2] and ..
  10. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001
    ..Collectively these studies demonstrate that filamin-dependent SHIP-2 localization critically regulates phosphatidylinositol 3 kinase signaling to the actin cytoskeleton...
  11. ncbi SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line
    Sylvie Giuriato
    Interdisciplinary Research Institute IRIBHN, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, 1070, Brussels, Belgium
    Biochem Biophys Res Commun 296:106-10. 2002
    b>SHIP2 belongs to the inositol 5-phosphatase family and is characterized by a phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) 5-phosphatase activity...
  12. ncbi Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I
    Nagendra Prasad
    Department of Cancer Molecular Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Cell Sci 115:3807-15. 2002
    ..Recently we have reported a novel function for SHIP2 in cell adhesion and spreading...
  13. ncbi Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome
    Pamela J Kaisaki
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Diabetes 53:1900-4. 2004
    Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity...
  14. ncbi SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 280:13129-36. 2005
    ..b>SHIP2 dephosphorylates phosphatidylinositol 3,4,5-trisphosphate generated by the activated phosphatidylinositol 3'-..
  15. ncbi The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading
    Alexandra Koch
    Institut fur Biochemie, Medizinische Hochschule Hannover, OE 4310, Carl Neuberg Str 1, Hannover D 30623, Germany
    Oncogene 24:3436-47. 2005
    ....
  16. ncbi Association of SH-2 containing inositol 5'-phosphatase 2 gene polymorphisms and hyperglycemia
    Satoru Ishida
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
    Pancreas 33:63-7. 2006
    SH-2 containing inositol 5'-phosphatase 2 (SHIP2) is a family of inositol 5'-phosphatases, which possess the 5'-phosphatase activity that hydrolyzes phosphatidylinositol-3, 4, 5-trisphosphate to phosphatidylinositol-3, 4-bisphosphate and ..
  17. ncbi The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner
    Judith H Raaijmakers
    Department of Physiological Chemistry and Centre of Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Cell Signal 19:1249-57. 2007
    ..In a yeast two-hybrid screen for new interaction partners of Arap3, we identified the PI 5'-phosphatase SHIP2 as an interaction partner of Arap3...
  18. ncbi Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection
    Shuji Sumie
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Oncol Rep 18:545-52. 2007
    ..inositol phosphatase (SHIP) 2 is a negative regulator of intracellular insulin signaling; however, changes in SHIP2 expression have not been investigated in HCC...
  19. ncbi Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA
    Carcinogenesis 29:25-34. 2008
    ..A 5'-phosphoinositol phosphatase, SH2-containing 5'-inositol phosphatase (SHIP2), regulates insulin signaling and its genetic knockout prevents high-fat diet-induced obesity in mice...
  20. pmc NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    Biochemistry 47:12721-8. 2008
    ..It has been recently reported that the lipid phosphatase Ship2 regulates endocytosis of the EphA2 receptor, a process that has been investigated as a possible route to reduce ..
  21. doi High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival
    Nagendra K Prasad
    Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Tumour Biol 29:330-41. 2008
    SH2-containing 5'-inositol phosphatase (SHIP2) is a known regulator of insulin function. Genetic knockout of SHIP2 in mice causes mild insulin hypersensitivity and prevents high-fat-diet-induced obesity...
  22. doi Phosphoinositides influence pathogen surfing: EPEC rights the SHIP
    Kenneth G Campellone
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Host Microbe 7:1-2. 2010
    ..A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.
  23. doi Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation
    Katherine Smith
    University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB21QP, UK
    Cell Host Microbe 7:13-24. 2010
    ..We demonstrate that Y483 and Y511 within tandem ITIM-like sequences are essential for recruiting SHIP2, a host inositol phosphatase...
  24. doi Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma
    Xiaojuan Zhou
    Department of Otolaryngology Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Arch Med Res 42:589-95. 2011
    b>SHIP2, an important negative regulator of insulin signaling, has recently been found to be involved in cancer development and progression.
  25. pmc Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia
    Jennifer E Below
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 92:137-43. 2013
    ..Evaluation of 12 families with opsismodysplasia revealed that INPPL1 mutations explain ~60% of cases overall, including both of the families in our cohort with more than one affected child and 50% of the simplex cases...
  26. pmc Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia
    Celine Huber
    Département de génétique, Unité INSERM U781, Université Paris Descartes Sorbonne Paris Cité, Fondation Imagine, Hopital Necker Enfants Malades, Paris 75015, France
    Am J Hum Genet 92:144-9. 2013
    ..Our finding of INPPL1 mutations in OPS, a severe spondylodysplastic dysplasia with major growth plate disorganization, supports a key and specific role of this enzyme in endochondral ossification...
  27. pmc Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer
    Maoying Fu
    Department of Infectious Diseases, The First People s Hospital of Kunshan Affiliated with Jiangsu University Suzhou 215000, China
    Int J Clin Exp Pathol 6:2185-91. 2013
    SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a vital regulator of phosphoinositide pools in metabolic pathways and is considered to downregulate phosphatidylinositol 3'-kinase signaling, which underlies the development of several ..
  28. pmc High expression of inositol polyphosphate phosphatase-like 1 associates with unfavorable survival in hepatocellular carcinoma
    Maoying Fu
    Department of Infectious Diseases, The First People s Hospital of Kunshan Affiliated with Jiangsu University Suzhou 215000, China
    Int J Clin Exp Pathol 6:2515-22. 2013
    Inositol polyphosphate phosphatase-like 1 (INPPL1), also known as SH2-containing inositol 5'-phosphatase 2 (SHIP2), has been suggested to act downstream of the PI3K/AKT pathway and play an important function in tumor development and ..
  29. ncbi Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
    Guanglei Zhuang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 282:2683-94. 2007
    ..Here we show that SHIP2 (Src homology 2 domain-containing phosphoinositide 5-phosphatase 2) is recruited to activated EphA2 via a ..
  30. ncbi SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology and First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 279:14835-43. 2004
    SH2-containing inositol phosphatase 2 (SHIP2) is a physiologically important negative regulator of insulin signaling by hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI 3,4,5-trisphosphate in the target tissues of insulin...
  31. doi Gene expression in canine atopic dermatitis and correlation with clinical severity scores
    Shona H Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    J Dermatol Sci 55:27-33. 2009
    ..Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD...
  32. ncbi Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade
    Daniela F Bertelli
    Department of Physiology and Biophysics, University of Campinas 6040 Campinas SP, Brazil
    Am J Physiol Endocrinol Metab 284:E679-87. 2003
    ..the expression and activity of the 5-inositol, lipid phosphatase SH2 domain-containing inositol phosphatase (SHIP2), and the serine phosphorylation of p85/PI 3-kinase...
  33. ncbi PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
    Xiaoqing Tang
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 280:22523-9. 2005
    ..in mice suggested that two phosphoinositide phosphatases, SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negatively regulate this insulin signaling ..
  34. ncbi Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling
    H Ishihara
    First Department of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930 0194, Japan
    Biochem Biophys Res Commun 260:265-72. 1999
    ..We have now cloned the rat SHIP isozyme (SHIP2) cDNA from skeletal muscle, which is one of the most important target tissue of insulin action...
  35. ncbi Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism
    Rolf Grempler
    Department of Metabolic Diseases, Boehringer Ingelheim GmbH and Co KG, Biberach, Germany
    Diabetes 56:2235-41. 2007
    ..Recent data have established the lipid phosphatase SH2 domain-containing inositol phosphatase 2 (SHIP2) as a critical negative regulator of insulin signal transduction...
  36. doi The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain
    Yoshiyuki Soeda
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Mol Endocrinol 24:1965-77. 2010
    ..In the present study, we found that SH2-containing inositol 5'-phosphatase 2 (SHIP2), a negative regulator of phosphatidylinositol 3,4,5-trisphosphate-mediated signals, is widely expressed in adult ..
  37. pmc SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels
    Sylvie Giuriato
    INSERM U563, Department of Oncogenesis and Signaling in Hematopoietic Cells, IFR30, Hopital Purpan, 31059 Toulouse Cedex, France
    Biochem J 376:199-207. 2003
    Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling ..
  38. ncbi Relationship between spleen tyrosine kinase and phosphatidylinositol 5' phosphatase expression and secretion from human basophils in the general population
    Donald W Macglashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:626-33. 2007
    ..Previous studies have suggested that expression levels of spleen tyrosine kinase (syk) or phosphatidylinositol 5' phosphatase (SHIP) may explain certain extreme human basophil phenotypes...
  39. ncbi Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts
    Daniel Blero
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Belgium
    FEBS J 272:2512-22. 2005
    b>SHIP2, the ubiquitous SH2 domain containing inositol 5-phosphatase, includes a series of protein interacting domains and has the ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)]in vitro...
  40. ncbi Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Pharmacol Ther 112:799-809. 2006
    ..Lipid phosphatases, src homology 2 domain containing inositol 5'-phosphatase 2 (SHIP2) and skeletal muscle and kidney-enriched inositol phosphatase (SKIP) hydrolyze PI(3,4,5)P(3) to PI(3,4)P(2) and ..
  41. ncbi The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners
    Sheela Onnockx
    Institute of Interdisciplinary Research IRIBHM, Brussels, Belgium
    J Cell Physiol 214:260-72. 2008
    b>SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is a phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase containing various motifs susceptible to mediate protein-protein interaction...
  42. doi The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity
    Jingwei Xie
    Institute of Interdisciplinary Research IRIBHM, School of Medicine, Free University of Brussels, Campus Erasme, Building C, Route de Lennik 808, B 1070 Brussels, Belgium
    Cell Signal 20:1432-41. 2008
    b>SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is an ubiquitously expressed phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase which contains various motifs susceptible to mediate protein-protein ..
  43. ncbi SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Int J Oncol 34:97-105. 2009
    The phosphoinositol phosphatase SHIP2 is an important regulator of energy metabolism...
  44. ncbi The lipid phosphatase SHIP2 controls insulin sensitivity
    S Clement
    IRIBHN, IBMM, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Nature 409:92-7. 2001
    ..Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family...
  45. ncbi Metabolic switching of PI3K-dependent lipid signals
    C P Downes
    Division of Molecular Physiology, James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem Soc Trans 35:188-92. 2007
    ..by a distinct family of enzymes exemplified by SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase 1] and SHIP2. Mouse knockout studies, however, suggest that PTEN and SHIP2 have profoundly different biological functions...
  46. ncbi Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice
    Syota Kagawa
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Endocrinology 149:642-50. 2008
    SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in ..
  47. ncbi Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries
    D Allen Annis
    Aileron Therapeutics, Inc, Cambridge, MA 02139, USA
    Comb Chem High Throughput Screen 12:760-71. 2009
    This manuscript describes the discovery and characterization of inhibitors of the lipid phosphatase SHIP2, an important target for the treatment of Type 2 diabetes, using the Automated Ligand Identification System...
  48. pmc LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2
    Tetsuji Takabayashi
    Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, University of Fukui, Fukui 910 1193, Japan
    J Biol Chem 285:16155-65. 2010
    ..accumulates, with the Filamin A-binding Src homology 2 domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2)...
  49. doi Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes
    Akira Suwa
    Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    Eur J Pharmacol 642:177-82. 2010
    Lipid phosphatase SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) plays an important role in the regulation of insulin signaling. In this report, we identified AS1938909, a novel small-molecule SHIP2 inhibitor...
  50. pmc The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:307-15. 2010
    ..In this study, we show that the inositol 5-phosphatase SHIP2, a negative regulator of PI(3,4,5)P(3)-dependent signaling, also negatively regulates PI(4,5)P(2) levels and is ..
  51. pmc Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle
    Carrie E McCurdy
    Department of Kinesiology, University of Wisconsin, 2000 Observatory Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 285:E693-700. 2003
    ..We also assessed changes in the abundance of SH2 domain-containing inositol phosphatase (SHIP2), a negative regulator of insulin signaling...
  52. pmc Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN
    Adel Mandl
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Mol Cell Biol 27:8098-112. 2007
    ..Knockdown of the lipid phosphatase Ship2, on the other hand, dramatically increased the steady-state levels of PI-3,4,5-P3 but did not affect Akt ..
  53. doi Tyrosine phosphorylation of SHIP promotes its proteasomal degradation
    Jens Ruschmann
    The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 38:392-402, 402.e1. 2010
    ..We sought to determine the mechanism(s) involved in its downregulation by BCR-ABL and by interleukin (IL)-4...
  54. pmc Novel phosphotyrosine targets of FGFR2IIIb signaling
    Yongde Luo
    IBT Proteomics and Nanotechnology Laboratory, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030 3303, USA
    Cell Signal 21:1370-8. 2009
    ..activities of FGFR1 that included multi-substrate organizers FRS2alpha and IRS4, ERK2 and phosphatases SHP2 and SHIP2. It uniquely phosphorylated CDK2 and phosphatase PTPN18 on sites involved in the attenuation of cell proliferation,..
  55. ncbi Endogenous SHIP2 does not localize in lipid rafts in 3T3-L1 adipocytes
    Christine Jacobs
    Faculte de Medecine, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, BatC 4 126, Route de Lennik 808, B 1070 Bruxelles, Belgium
    FEBS Lett 565:70-4. 2004
    SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP2) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) into phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2))...
  56. ncbi LPS-induced upregulation of SHIP is essential for endotoxin tolerance
    Laura M Sly
    The Terry Fox Laboratory, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada
    Immunity 21:227-39. 2004
    ..Moreover, an initial LPS treatment of wild-type BMmphis or BMMCs increases the level of SHIP, but not SHIP2 or PTEN, and this increase is critical for the hyporesponsiveness to subsequent LPS stimulation...
  57. ncbi Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
    P R Shepherd
    Department of Biochemistry and Molecular Biology, University College London, Gower St, London WC1E 6BT, UK
    Acta Physiol Scand 183:3-12. 2005
    ..These include inhibitory phosphorylation events, lipid phosphatases such as PTEN and SHIP2 and inhibitor proteins of the suppressors of cytokine signalling (SOCS) family...
  58. ncbi PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1
    Karim Benkirane
    Clinical Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 290:H390-7. 2006
    ..initiation factor 4E-binding protein 1 (4E-BP1), as well as Src homology (SH) 2-containing inositol phosphatase 2 (SHIP2)...
  59. ncbi Motif decomposition of the phosphotyrosine proteome reveals a new N-terminal binding motif for SHIP2
    Martin Lee Miller
    Center for Biological Sequence Analysis, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Lyngby, Denmark
    Mol Cell Proteomics 7:181-92. 2008
    ..was identified and validated as a binding motif for the SH2 domain-containing inositol phosphatase SHIP2. Our decomposition of the in vivo Tyr(P) proteome furthermore suggests that two-thirds of the Tyr(P) sites mediate ..
  60. doi Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes
    Yulia Artemenko
    Chronic Disease Program, Ottawa Health Research Institute and Departments of Medicine and Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Cell Physiol 218:228-36. 2009
    ..SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) dephosphorylates PI(3,4,5)P3, and also binds to Shc...
  61. doi The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biochem J 419:29-49. 2009
    ..b>SHIP2 polymorphisms are associated with a predisposition to insulin resistance...
  62. doi Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs
    Eva Lincová
    Department of Cytokinetics, Institute of Biophysics, AS CR, Brno, Czech Republic
    Biochem Pharmacol 78:561-72. 2009
    ..cancer cell line LNCaP, lacking both critical enzymes in the negative control of PKB/Akt activation, PTEN and SHIP2, was the most sensitive to these effects, as assessed by analysing the cell cycle profile and expression of cell ..
  63. doi PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase
    Amit Gupta
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, S A S Nagar, Punjab 160 062, India
    Mol Cell Endocrinol 309:55-62. 2009
    ..Here we report that PTEN and SHIP2, the phosphatases widely implicated as negative regulators of insulin signaling, to be responsible for ..
  64. doi Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling
    Karen Zwaenepoel
    Protein Phosphorylation and Proteomics Laboratory, Dept of Molecular Cell Biology, Faculty of Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    FASEB J 24:538-47. 2010
    ..characterized a complex between the Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2) and a PP2A holoenzyme comprising PR130/B''alpha1 as a regulatory subunit (PP2A(T130)) in several mammalian cell ..
  65. doi Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes
    Fernando F Anhê
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Mol Cell Endocrinol 319:30-8. 2010
    ..serine phosphorylation and insulin-induced glucose uptake, and increased the expression of the lipid phosphatase Ship2. Additionally, binding of Smad5 to Akt2 gene is decreased in dexamethasone-treated rats and increased in L6 ..
  66. doi SHIP2 and its involvement in various diseases
    Akira Suwa
    Astellas Pharma, Inc, Pharmacology Research Labs, Drug Discovery Research, 21, Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    Expert Opin Ther Targets 14:727-37. 2010
    Inositol polyphosphate 5-phosphatase (SHIP2) is an important negative regulator of intracellular phosphatidylinositol phosphate, a key second messenger of various intracellular signaling pathways...
  67. pmc Mutation altering the miR-184 seed region causes familial keratoconus with cataract
    Anne E Hughes
    Centre for Public Health, The Queen s University of Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BN, Northern Ireland, UK
    Am J Hum Genet 89:628-33. 2011
    ..Awareness of the important function of miRNAs could aid identification of susceptibility genes and new therapeutic targets for treatment of both rare and common diseases...
  68. pmc NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2
    Hyeong J Lee
    Department of Physiology and Biophysics, MetroHealth, Cleveland, OH 44109, USA
    Structure 20:41-55. 2012
    ..Here we solved the structure of the EphA2-SHIP2 SAM:SAM heterodimeric complex by use of NMR restraints from chemical shift perturbations, NOE and RDC experiments...
  69. doi SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice
    Y Ichihara
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    J Neuroendocrinol 25:372-82. 2013
    SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a lipid phosphatase that negatively regulates the metabolic signalling of insulin in peripheral tissues; however, the expression of SHIP2 in the hypothalamus and its functional roles ..
  70. doi Exome sequencing identifies a novel INPPL1 mutation in opsismodysplasia
    Aritoshi Iida
    Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    J Hum Genet 58:391-4. 2013
    ..E654del) within the central catalytic 5-phosphate domain. Our results further support that INPPL1 is the disease gene for opsismodysplasia and that opsismodysplasia has genetic heterogeneity. ..
  71. pmc Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities
    Carlo De Lorenzo
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Int J Genomics 2013:376454. 2013
    ....
  72. doi Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines
    Laurence Deneubourg
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles ULB, Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
    Cell Signal 26:1193-203. 2014
    The SH2 containing inositol 5-phosphatase SHIP2 is a member of the mammalian phosphoinositide polyphosphate 5-phosphatase family...
  73. doi Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt
    Yan Ye
    Department of Immunology, Anhui Medical University, Hefei, 230032, Anhui, China
    J Gastroenterol 51:230-40. 2016
    The Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is implicated in diabetes, arthrosclerosis, and cancer. However, the role of SHIP2 in human gastric cancer remains unclear.
  74. doi Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2
    Johanne Le Coq
    Cell Signalling and Adhesion Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, Calle Melchor Fernandez Almagro 3, 28029, Madrid, Spain
    Protein J 35:225-30. 2016
    The Src homology 2 containing inositol 5-phosphatase 2 (SHIP2) catalyses the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2...
  75. pmc Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells
    Yan Ye
    Department of Immunology, Anhui Medical University, Hefei 230032, China
    Int J Mol Sci 18:. 2017
    Past studies have shown that the Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is commonly downregulated in gastric cancer, which contributes to elevated activation of PI3K/Akt signaling, proliferation and tumorigenesis of ..
  76. ncbi The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases
    Katrien Backers
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Campus Erasme, Bldg C, 808 Route de Lennik, 1070 Brussels, Belgium
    Adv Enzyme Regul 43:15-28. 2003
  77. ncbi Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 144:4204-14. 2003
    Src homology domain 2 (SH2)-containing inositol phosphatase 2 (SHIP2) possesses 5-phosphatase activity and an SH2 domain...
  78. ncbi Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    Christiane B Knobbe
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    Brain Pathol 13:507-18. 2003
    ..Taken together, our data indicate that different genes related to the Pi3k/Akt signalling pathway may be aberrant in glioblastomas...
  79. ncbi SHIP2: an emerging target for the treatment of type 2 diabetes mellitus
    James W Baumgartener
    8491 N E Paulanna Lane, Bainbridge Island, WA 98110, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:291-8. 2003
    ..Mice lacking one of these enzymes, Src-Homology Inositol Phosphatase-2 (SHIP2), demonstrate increased insulin sensitivity, suggesting that pharmacological inhibition of SHIP2 could alleviate ..
  80. ncbi Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes
    Prem M Sharma
    Department of Medicine 0673, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
    Mol Endocrinol 19:421-30. 2005
    The Src homology 2-containing 5' inositolphosphatases (SHIP and SHIP2) dephosphorylate 3'-phosphorylated PtdIns on the 5' position, decreasing intracellular levels of PtdIns 3,4,5-P3...
  81. ncbi Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing
    Zhiyang Gao
    Department of Pathology, Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 280:9375-89. 2005
    ..Overexpression of the phospholipid phosphatases, SHIP2 and/or PTEN, inhibited PDGF-BB-induced phosphorylation of Akt and ERK1/2 in PDGFR-betaDelta/Delta fibroblasts but ..
  82. ncbi Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    Mark W Sleeman
    Regeneron Pharmaceuticals, Inc 777 Old Saw Mill River Road, Tarrytown, New York 10591 6707, USA
    Nat Med 11:199-205. 2005
    Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death...
  83. pmc Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
    Ana Carolina Braga Marçano
    J Med Genet 44:603-5. 2007
    Inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) is a negative regulator of insulin signalling and has previously been found to be associated with hypertension, obesity and type 2 diabetes in a cohort of families with diabetes ..
  84. pmc Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2
    Sarbjit S Saini
    Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore MD 21224, USA
    Clin Immunol 132:342-8. 2009
    ..04). In summary, our results suggest a possible predilection for urticarial MC to spontaneously degranulate upon IgE sensitization contributing to the increased pruritus associated with CIU...
  85. doi Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin
    Feng Wang
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University Tokyo, Japan
    J Biochem 150:83-93. 2011
    ..Pharbin can hydrolyse PI(4,5)P(2) and PI(3,4,5)P(3) and has the same substrate specificity as SHIP2 and SKIP, which negatively regulate PI3K signalling...
  86. pmc SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain
    Junya Hasegawa
    Division of Membrane Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Cell Biol 193:901-16. 2011
    ..Interestingly, SHIP2 (the PI(3,4,5)P(3) 5-phosphatase, src-homology 2-containing inositol-5-phosphatase 2) was identified as a binding ..
  87. doi Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene
    Qi Xiong
    Hubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China
    Mol Cell Biochem 360:225-33. 2012
    Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) has been identified as 5'-inositol phosphatase that hydrolyzes PI(3,4,5)P(3) to PI(3,4)P(2), which negatively regulates insulin-induced Akt signaling in skeletal muscle...
  88. pmc Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer
    Gwenny M Fuhler
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York 13210, United States of America
    Mol Med 18:65-75. 2012
    ..It has long been thought that the lipid phosphatases SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 act as tumor suppressors by counteracting with the survival signal induced by this pathway through hydrolysis or ..
  89. doi Can Alzheimer disease be a form of type 3 diabetes?
    Giulia Accardi
    Department of Biopathology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, Italy
    Rejuvenation Res 15:217-21. 2012
    ..between metabolic syndrome and specific single-nucleotide polymorphisms (SNPs) in the gene INPPL1, encoding for SHIP2, a SH2 domain-containing inositol 5-phosphatase involved in insulin signaling, has been described...
  90. doi Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse
    Eléonore Dubois
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Institut de Biologie et de Médecine Moléculaires IBMM, Universite Libre de Bruxelles ULB, Gosselies, Belgium
    Cell Signal 24:1971-80. 2012
    The function of the phosphoinositide 5-phosphatase Ship2 was investigated in a new mouse model expressing a germline catalytically-inactive Ship2(∆/∆) mutant protein...
  91. pmc Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer
    Eliot T McKinley
    Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 8:e80207. 2013
    ..kinase C (PKCδ), CUB-domain-containing protein 1 (CDCP1), Type-II SH2-domain-containing inositol 5-phosphatase (SHIP2), and receptor protein-tyrosine phosphatase alpha (RPTPα)...
  92. pmc High SHIP2 expression indicates poor survival in colorectal cancer
    Ju Yang
    Department of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Suzhou 215000, China
    Dis Markers 2014:218968. 2014
    SH2-containing inositol 5'-phosphatase 2 (SHIP2), which generally regulates insulin signaling, cytoskeleton remodeling, and receptor endocytosis, has been suggested to play a significant role in tumor development and progression...
  93. ncbi Single nucleotide polymorphisms on SHIP2 is associated with Type 2 diabetes mellitus in Chinese Han population
    Y M Hao
    Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People s Republic of China
    Eur Rev Med Pharmacol Sci 19:129-37. 2015
    ..Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product PI(3,4,5)P3 to PI(3,4)P2, which contributes to the ..
  94. pmc PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena
    Shannon K Hughes
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
    Mol Biol Cell 26:3867-78. 2015
    ..Mena also interacts with the 5' inositol phosphatase SHIP2, which is important for the recruitment of the Mena-PTP1B complex to the EGFR...
  95. pmc Novel compound heterozygous mutations in inositol polyphosphate phosphatase-like 1 in a family with severe opsismodysplasia
    Cori Feist
    Departments of aPerinatology bOrthopaedics and Rehabilitation, Oregon Health and Science University, Portland, Oregon cDepartment of Orthopaedic Surgery, Bone and Joint Center, Henry Ford Hospital System, Detroit, Michigan, USA
    Clin Dysmorphol 25:152-5. 2016
    ..Unique compound heterozygous variants in the inositol polyphosphate phosphatase-like 1 (INPPL1) gene encoding the SHIP2 protein were identified in both affected individuals. One variant was inherited from each unaffected parent...
  96. doi The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells
    William s Elong Edimo
    IRIBHM, Universite Libre de Bruxelles, Campus Erasme, Batiment C, 808 Route de Lennik, B 1070, Bruxelles, Belgium
    Biochem Biophys Res Commun 476:508-14. 2016
    ..b>SHIP2, one family member, is known to interact with growth factor receptors and cytoskeletal proteins...
  97. pmc PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis
    Aline Awad
    Aline Awad, Ama Gassama Diagne, Inserm Unité 1193, Hopital Paul Brousse, 94800 Villejuif, France
    World J Hepatol 9:18-29. 2017
    ..SH2-containing inositol polyphosphate 5-phosphatase (SHIP2), phosphoinositide 3-kinase (PI3K) and their lipid products PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively, play ..
  98. ncbi Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors
    Hajime Ishihara
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Mol Endocrinol 16:2371-81. 2002
    Lipid phosphatase SHIP2 [Src homology 2 (SH2)-containing inositol 5'-phosphatase 2] has been shown to be a physiologically critical negative regulator of insulin signaling...
  99. ncbi Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases
    Megan V Astle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 58:451-6. 2006
    ..we highlight recently established insights into the functions of two well characterized 5-phosphatases OCRL and SHIP2, which have been the subject of extensive functional studies, and the characterization of recently identified ..
  100. doi Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1
    Simone Lemeer
    Chair of Proteomics and Bioanalytics, Technische Universitat Munchen, Emil Erlenmeyer Forum 5, 85354 Freising, Germany
    J Proteomics 75:3465-77. 2012
    ..numerous signaling proteins as new putative phosphotyrosine mediated interactors including RasGAP, SHIP1, SHIP2, STATs, PI3K and the SRC family kinases...
  101. ncbi Role of inhibitory BCR co-receptors in immunity
    Takeshi Tsubata
    Laboratory of Immunology, Tokyo Medical and Dental University Graduate School of Biomedical Sciences, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
    Infect Disord Drug Targets 12:181-90. 2012
    ..protein tyrosine phosphatase 1 (SHP-1), SHP-2, SH2 domain- containing inositol 5-phosphatase 1 (SHIP1) and SHIP2 depending on receptors. These phosphatases then negatively regulate B cell antigen receptor (BCR) signaling...

Research Grants9

  1. Spiro Getsios; Fiscal Year: 2016
    ..The importance of the EphA2 cytoplasmic domain in inhibiting keratinocyte differentiation [by interacting with SHIP2, a modulator of the EGFR signaling pathway,] will be determined using genetic approaches that remove key signaling ..
  2. Mechanisms of Chemo/Radioresistance in Human Gliomas
    Eliot M Rosen; Fiscal Year: 2012
    ..We found that two SH2-containing inositol-5-phosphatases (SHIP1 and SHIP2) regulate glioma cell sensitivity to chemotherapeutics...
  3. Robert M Lavker; Fiscal Year: 2016
    ..We successfully identified the lipid phosphatase SHIP2 as one of the targets of miR-205 and observed that miR-205 functions to enhance cell survival and alter ..
  4. Identification of Signaling Targets of EphA2
    Sonja Schmidt; Fiscal Year: 2005
    ..proteins, including guanine nucleotide exchange factor Vav3, adaptor protein Nck2 and lipid phosphatase SHIP2. In this application, I propose to finish the screens and investigate the role of EphA2-interacting proteins, Vav3 ..
  5. SEARCH FOR SELECTIVE THERAPY OF CML
    Bayard Clarkson; Fiscal Year: 2007
    ..All of these proteins have now been identified, including 3 novel proteins p62dok-1, p56dok-2, and SHIP2. The protein-protein and protein-phospholipid interactions involved in recognizing and initiating specific signals ..
  6. LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY
    BETH DREES; Fiscal Year: 2002
    ..These assays will be aimed at measuring the activity of the lipid phosphatases PTEN, SHIP1, and SHIP2, which modulate phosphoinositide 3-kinase signaling by conversion of Pl (3,4,5) P3 to Pl (4,5) P2 and Pl(3,4)P2 ..
  7. Indentification of AKT2/aPKC Substrates in Adipocytes
    Prem Sharma; Fiscal Year: 2005
    ..We believe that the findings from the proposed investigations will improve our general understanding of players of insulin resistance and offer potential insight into new therapeutic modalities. ..
  8. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  9. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..