SHANK1

Summary

Gene Symbol: SHANK1
Description: SH3 and multiple ankyrin repeat domains 1
Alias: SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains protein 1, SSTR-interacting protein, somatostatin receptor-interacting protein
Species: human

Top Publications

  1. doi Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region
    Katrin Falley
    Institut fur Humangenetik, Universitätsklinikum Hamburg Eppendorf Martinistrasse 52 20246 Hamburg, Germany
    Traffic 10:844-57. 2009
  2. pmc SHANK1 Deletions in Males with Autism Spectrum Disorder
    Daisuke Sato
    The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:879-87. 2012
  3. ncbi Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain
    H Zitzer
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 274:32997-3001. 1999
  4. ncbi Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3' untranslated region of Shank1 mRNA
    Tobias M Bockers
    Institut für Anatomie Westfälishe Wilhelms Universität Münster, Germany
    Mol Cell Neurosci 26:182-90. 2004
  5. doi Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
    Norman E Davey
    Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Ireland
    FEBS J . 2016
  6. doi Dysfunction of SHANK2 and CHRNA7 in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci
    B Chilian
    Institute of Human Genetics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Genet 84:560-5. 2013
  7. pmc SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region
    Marie Germaine Mameza
    From the Institut für Humangenetik, Universitätskrankenhaus Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 288:26697-708. 2013
  8. pmc A non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA
    Katrin Studtmann
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 9:e88518. 2014
  9. doi Ultrasonic vocalizations in Shank mouse models for autism spectrum disorders: detailed spectrographic analyses and developmental profiles
    Markus Wohr
    Behavioral Neuroscience, Experimental and Biological Psychology, Philipps University of Marburg, Gutenbergstr 18, D 35032 Marburg, Germany Electronic address
    Neurosci Biobehav Rev 43:199-212. 2014
  10. pmc Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments
    Claire S Leblond
    Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France CNRS UMR 3571 Genes, Synapses and Cognition, Institut Pasteur, Paris, France University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France
    PLoS Genet 10:e1004580. 2014

Research Grants

  1. Guoping Feng; Fiscal Year: 2016
  2. Activity-Dependent Regulation of Synapses by Shank
    ALBERT HUNG; Fiscal Year: 2005

Scientific Experts

  • Markus Wohr
  • Michael J Schmeisser
  • MIHAELA R MIHAILESCU
  • Xiaohong Gong
  • Yong hui Jiang
  • Dariusz Orlowski
  • Karima Azdad
  • Jun Hyuck Lee
  • Jill L Silverman
  • Francesco Roselli
  • Tobias M Boeckers
  • Carlo Sala
  • J H Tao-Cheng
  • Guido Meyer
  • M Sheng
  • Hans Jurgen Kreienkamp
  • Tatsuo Suzuki
  • Dietmar Richter
  • Guoping Feng
  • ALBERT HUNG
  • Stefan Kindler
  • Sonja Halbedl
  • Albert Y Hung
  • Michael Schoen
  • Claire S Leblond
  • Daisuke Sato
  • Andreas M Grabrucker
  • Michael R Kreutz
  • Katrin Falley
  • Janin Schütt
  • Christopher Heise
  • Tianyun Wang
  • Tasnuva Sarowar
  • Michaela Soltau
  • Ping Lu
  • Christina Chen
  • Harold D MacGillavry
  • Norman E Davey
  • Henry A Dunn
  • Snezana Stefanovic
  • Yan Li
  • Wenjie Mao
  • Kathryn R Williams
  • Gary J Bassell
  • Katrin Studtmann
  • Irina Epstein
  • Yang Zhang
  • Gudrun A Rappold
  • B Chilian
  • Tatiana Catarino
  • Christopher Gillberg
  • Maria Rastam
  • Marion Leboyer
  • Stephen W Scherer
  • Thomas Bourgeron
  • Marie Germaine Mameza
  • Mark Lathrop
  • Ayantika Pal
  • Guillaume Huguet
  • Dalila Pinto
  • Richard Delorme
  • Peter Szatmari
  • Joseph E Pick
  • Leonhard Lennertz
  • Peng Wei
  • Kensuke Futai
  • Susanne Gessert
  • Pengwen Wang
  • Ying Ren
  • Gordana Miletic
  • Emiley Pham
  • S Lim
  • Jinyoung Jung
  • Eunjoon Kim
  • Clifford C Sung
  • Young Jun Im
  • Jürgen Bockmann
  • Leiming Zhang
  • Seong Ho Park
  • S Naisbitt
  • Eckart D Gundelfinger
  • Silvana Beri
  • Peter Iglauer
  • Mio Nonaka
  • Noemi Tonna
  • Sonia Fieulaine
  • Gareth M Thomas
  • Arne Quitsch
  • E Kim
  • Kerstin Berhörster

Detail Information

Publications78

  1. doi Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region
    Katrin Falley
    Institut fur Humangenetik, Universitätsklinikum Hamburg Eppendorf Martinistrasse 52 20246 Hamburg, Germany
    Traffic 10:844-57. 2009
    ..We have analyzed dendritic localization of shank1 mRNAs; shank proteins (shank1-3) are scaffolding molecules of the postsynaptic density (PSD) of excitatory ..
  2. pmc SHANK1 Deletions in Males with Autism Spectrum Disorder
    Daisuke Sato
    The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:879-87. 2012
    ..The SHANK gene family consists of three members (SHANK1, SHANK2, and SHANK3), which encode scaffolding proteins required for the proper formation and function of neuronal ..
  3. ncbi Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain
    H Zitzer
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 274:32997-3001. 1999
    ..This protein termed somatostatin receptor interacting protein is characterized by a novel domain structure, consisting of six N-terminal ankyrin repeats ..
  4. ncbi Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3' untranslated region of Shank1 mRNA
    Tobias M Bockers
    Institut für Anatomie Westfälishe Wilhelms Universität Münster, Germany
    Mol Cell Neurosci 26:182-90. 2004
    ..In situ hybridization revealed that Shank1/SSTRIP and Shank2/ProSAP1 mRNAs are widely expressed early in postnatal brain development whereas Shank3/ProSAP2 ..
  5. doi Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
    Norman E Davey
    Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Ireland
    FEBS J . 2016
    ..For SHANK1 PDZ, we establish a novel consensus TxF motif for its non-C-terminal ligands...
  6. doi Dysfunction of SHANK2 and CHRNA7 in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci
    B Chilian
    Institute of Human Genetics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Genet 84:560-5. 2013
    ..with mutations in genes encoding proteins important for the formation and stabilization of synapses, such as SHANK1-3...
  7. pmc SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region
    Marie Germaine Mameza
    From the Institut für Humangenetik, Universitätskrankenhaus Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 288:26697-708. 2013
    ..Our data identify a new type of regulation of Shank proteins and suggest that mutations in the SHANK3 gene do not necessarily induce a loss of function, but may represent a gain of function with respect to specific interaction partners. ..
  8. pmc A non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA
    Katrin Studtmann
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 9:e88518. 2014
    ..translational control elements of the dendritically localized mRNA coding for the postsynaptic scaffold protein Shank1. In its 5' region, the human Shank1 mRNA exhibits two alternative translation initiation sites (AUG⁺¹ and AUG⁺..
  9. doi Ultrasonic vocalizations in Shank mouse models for autism spectrum disorders: detailed spectrographic analyses and developmental profiles
    Markus Wohr
    Behavioral Neuroscience, Experimental and Biological Psychology, Philipps University of Marburg, Gutenbergstr 18, D 35032 Marburg, Germany Electronic address
    Neurosci Biobehav Rev 43:199-212. 2014
    ..Among the most promising candidate genes for ASD is the SHANK gene family, including SHANK1, SHANK2 (ProSAP1), and SHANK3 (ProSAP2)...
  10. pmc Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments
    Claire S Leblond
    Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France CNRS UMR 3571 Genes, Synapses and Cognition, Institut Pasteur, Paris, France University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France
    PLoS Genet 10:e1004580. 2014
    ..In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads...
  11. pmc FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA
    Yang Zhang
    a Graduate School of Pharmaceutical Sciences Mylan School of Pharmacy Duquesne University Pittsburgh, PA USA
    RNA Biol 11:1364-74. 2014
    ..One of the FMRP in vivo targets, Shank1 mRNA, encodes the master scaffold proteins of the postsynaptic density (PSD) which regulate the size and shape of ..
  12. doi PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways
    Henry A Dunn
    J Allyn Taylor Centre for Cell Biology, Robarts Research Institute, and the Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Mol Pharmacol 88:624-39. 2015
    ..and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin repeat domain (Shank) proteins (Shank1, Shank2, and Shank3), partitioning defective proteins 3 and 6, multiple PDZ protein 1, Tamalin, neuronal nitric ..
  13. pmc Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons
    Wenjie Mao
    Brudnick Neuropsychiatric Research Institute and Program in Neuroscience, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA, 01604, USA
    Eur J Neurosci 41:1025-35. 2015
    The Shank genes (SHANK1, 2, 3) encode scaffold proteins highly enriched in postsynaptic densities where they regulate synaptic structure in spiny neurons...
  14. doi Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice
    Yan Li
    Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, United States
    Pharmacol Biochem Behav 135:70-82. 2015
    ..g., Nfkb1, Fos, Fmr1, Camk2a, Arc, Shank1, Nlgn2, and Rab3a). Neither drug reversed the age-associated decrease in stem cell proliferation...
  15. doi SHANK1 and autism spectrum disorders
    Xiaohong Gong
    MOE Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433, China
    Sci China Life Sci 58:985-90. 2015
    ..Recently, deletions and point mutations of the SHANK1 gene have been detected in ASD individuals, indicating the involvement of SHANK1 in ASD...
  16. pmc Fragile X mental retardation protein interactions with a G quadruplex structure in the 3'-untranslated region of NR2B mRNA
    Snezana Stefanovic
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA
    Mol Biosyst 11:3222-30. 2015
    ..We have previously shown that the interactions between FMRP and mRNAs of the PSD scaffold proteins PSD-95 and Shank1 are mediated via stable G-quadruplex structures formed within the 3'-untranslated regions of these mRNAs...
  17. pmc Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses
    Harold D MacGillavry
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
    Eur J Neurosci 43:179-93. 2016
    The family of Shank scaffolding molecules (comprising Shank1, 2 and 3) are core components of the postsynaptic density (PSD) in neuronal synapses...
  18. doi Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals
    Sonja Halbedl
    Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
    J Neurochem 137:26-32. 2016
    Autism-related Shank1, Shank2, and Shank3 are major postsynaptic scaffold proteins of excitatory glutamatergic synapses...
  19. pmc Developmental neurogenetics and multimodal neuroimaging of sex differences in autism
    Christina Chen
    Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA
    Brain Imaging Behav . 2016
    ..3, 5q12.3, 7q, 9q33.3, 11q13.4, 13q33.3, 16p11.2, 17q11-21, Xp22.33/Yp11.31, DRD1, NLGN3, MAOA, and SHANK1 deletion have been discovered in ASD...
  20. pmc Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus
    Christopher Heise
    Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany RG Neuroplasticity, Leibniz Institute for NeurobiologyMagdeburg, Germany
    Front Cell Neurosci 10:106. 2016
    Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses...
  21. ncbi Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation
    Ping Lu
    Tongji Stem Cell Research Center, Tongji University School of Medicine, Shanghai, 200092, China
    Sci China Life Sci 59:1093-1105. 2016
    ..of potassium channels (KCNA1, KCNC3, KCNG2, KCNIP4, KCNJ3, KCNK9, and KCNT1) and altered temporal regulation of SHANK1 and NNAT in FXS-iPSC derived neurons, indicating impaired neuronal differentiation and function in FXS patients...
  22. pmc De novo genic mutations among a Chinese autism spectrum disorder cohort
    Tianyun Wang
    The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China
    Nat Commun 7:13316. 2016
    ..CUL3, DOCK8 and ZNF292) and DN mutations in previous ASD candidates (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 and SHANK1)...
  23. pmc Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies
    Tasnuva Sarowar
    WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany
    Neural Plast 2016:8051861. 2016
    Shank proteins (Shank1, Shank2, and Shank3) act as scaffolding molecules in the postsynaptic density of many excitatory neurons...
  24. doi Translational neurobiology in Shank mutant mice--model systems for neuropsychiatric disorders
    Michael J Schmeisser
    Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany Electronic address
    Ann Anat 200:115-7. 2015
    The Shank family comprises three core postsynaptic scaffold proteins of excitatory synapses in the mammalian brain: Shank1, Shank2 and Shank3...
  25. pmc The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice
    Joseph E Pick
    Center for Neural Science, New York University, New York, New York 10003, USA
    Learn Mem 20:11-20. 2012
    ..Finally, we observed increased expression of Shank1 and NR2A expression in amygdalar slices from the Cdh1 cKO mice following the induction of LTP, suggesting a ..
  26. doi A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..We genotyped five common coding or promoter variants located in SHANK1, SHANK2 and SHANK3...
  27. doi Wistar rats subjected to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins
    D Orlowski
    Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark
    Stress 15:514-23. 2012
    ..genes associated with spine density and morphology (the synaptic scaffolding proteins: Spinophilin, Homer1-3, and Shank1-3)...
  28. ncbi [Effect of curcumin on synapse-related protein expression of APP/PS1 double transgenic mice]
    Peng Wei
    Key Laboratory of Pharmacology, Dongzhinmen Hospital, Beijing University of Chinese Medicine, Class III Biosafety Lab of State Administration of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 37:1818-21. 2012
    To observe the effect of curcumin on the expression of synapse-related proteins PSD-95 and Shank1 in APP/PS1 double transgenic mice.
  29. doi Regulation of synapse composition by protein acetylation: the role of acetylated cortactin
    Tatiana Catarino
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 3004 517, Portugal
    J Cell Sci 126:149-62. 2013
    ..We also found that acetylation of cortactin is correlated with decreased cortactin interaction with p140Cap and Shank1, and with lower cortactin phosphorylation at tyrosine 421...
  30. doi Chronic morphine exposure and its abstinence alters dendritic spine morphology and upregulates Shank1
    Ayantika Pal
    Neurobiology Department, Cell Biology and Physiology Division, CSIR Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
    Neurochem Int 62:956-64. 2013
    ..Such alterations were accompanied with significant upregulation of the postsynaptic protein Shank1 in synaptosomal enriched fractions...
  31. pmc Modeling autism by SHANK gene mutations in mice
    Yong hui Jiang
    Departments of Pediatrics and Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
    Neuron 78:8-27. 2013
    Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that organize an extensive protein complex at the postsynaptic density (PSD) of excitatory glutamatergic synapses...
  32. ncbi Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95
    Michaela Soltau
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Neurochem 90:659-65. 2004
    ..IRSp53 interacts with the postsynaptic shank1 scaffolding molecule in a cdc42 regulated manner...
  33. pmc Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil
    Irina Epstein
    Max Planck Institute for Brain Research, Max von Laue Strasse 4, Frankfurt am Main 60438, Germany
    Philos Trans R Soc Lond B Biol Sci 369:20130137. 2014
    ..Shank proteins, encoded by the three genes Shank1, Shank2 and Shank3 are scaffold molecules in the postsynaptic density of excitatory neurons that contribute to ..
  34. pmc Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior
    Markus Wohr
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20631. 2011
    ..To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with ..
  35. doi The spatio-temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development
    Susanne Gessert
    Institute for Biochemistry and Molecular Biology, Ulm University, Ulm, Germany
    Dev Dyn 240:1528-36. 2011
    ..We investigated for the first time the expression of the three family members named Shank1, ProSAP1/Shank2, and ProSAP2/Shank3 during Xenopus laevis development...
  36. pmc Loose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neurons
    Gordana Miletic
    Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    Pain 149:152-9. 2010
    ..In this study we examined the early consequences of the loose ligation of the sciatic nerve on Shank1 protein and message levels in the PSD of spinal dorsal horn neurons...
  37. doi The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands
    Jun Hyuck Lee
    Korea Polar Research Institute, Incheon 406 840, South Korea
    Biochem Biophys Res Commun 407:207-12. 2011
    ..Here, we have determined the crystal structure of the shank1 PDZ in complex with the βPIX C-terminal pentapeptide (642-646, DETNL) at 2...
  38. pmc Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
    Andreas M Grabrucker
    Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    EMBO J 30:569-81. 2011
    ..Furthermore, depletion of synaptic Zn(2+) along with the knockdown of zinc-insensitive Shank1 causes the rapid disintegration of PSDs and the loss of several postsynaptic molecules including Homer1, PSD-95 ..
  39. pmc Sociability and motor functions in Shank1 mutant mice
    Jill L Silverman
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Res 1380:120-37. 2011
    ..relevant to the diagnostic and associated symptoms of autism, comprehensive behavioral phenotyping on a line of Shank1 mutant mice was conducted on multiple measures of social interactions, social olfaction, repetitive behaviors, ..
  40. pmc Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    Emiley Pham
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    FEBS J 277:3051-67. 2010
    ..This was accompanied by a decrease in the levels of the postsynaptic proteins Shank1 and Shank3 in patients with Alzheimer's disease and in the brains of amyloid precursor protein transgenic mice...
  41. pmc Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons
    Albert Y Hung
    Departments of Brain and Cognitive Sciences and Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e9842. 2010
    ..ubiquitination and proteasome-dependent degradation of GKAP, and induces the loss of GKAP and associated scaffold Shank1 from postsynaptic sites...
  42. ncbi Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins
    S Lim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yusong Ku, Daejon, 305 701, Korea
    Mol Cell Neurosci 17:385-97. 2001
    The Shank family of proteins (also termed CortBP, ProSAP, or Synamon) is highly enriched in the postsynaptic density (PSD) of excitatory synapses in brain...
  43. pmc Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells
    Ryan R McWilliams
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80439, USA
    Biochem J 380:181-91. 2004
    ..Unlike Shank1 and Shank3, Shank2 [also known as Pro-SAP1 (proline-rich synapse-associated protein 1), CortBP1 (cortactin binding ..
  44. ncbi Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization
    Young Jun Im
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    J Biol Chem 278:48099-104. 2003
    ..Here we describe the crystal structures of Shank1 PDZ in its peptide free form and in complex with the C-terminal hexapeptide (EAQTRL) of guanylate kinase-..
  45. ncbi Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse
    Yataro Daigo
    Department of Medicine, University of Yamanashi Medical School, Yamanashi, Japan
    J Gastroenterol Hepatol 18:712-8. 2003
    ..The absence of IC-IM in W/WV mutants in the fundus provides a unique opportunity to study the molecular changes that are associated with the loss of these cells...
  46. ncbi The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42
    Eunhye Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:19220-9. 2003
    ..Considering the involvement of Rac1 and PAK in spine dynamics, these results suggest that Shank recruits beta PIX and PAK to spines for the regulation of postsynaptic structure...
  47. ncbi The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42
    Michaela Soltau
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Mol Cell Neurosci 21:575-83. 2002
    ..proteins are major scaffold proteins in glutamatergic synapses in the mammalian brain; expression of shank1/SSTRIP in hippocampal neurons induces morphological changes in dendritic spines, suggesting that shank1 is ..
  48. ncbi Interaction of G-protein-coupled receptors with synaptic scaffolding proteins
    H J Kreienkamp
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitatskrankenhaus Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Biochem Soc Trans 30:464-8. 2002
    ..the PDZ domain of the proline-rich synapse-associated protein (ProSAP)/somatostatin receptor-interacting protein (SSTRIP) family of postsynaptic proteins (SSTRIP, ProSAP1 and ProSAP2, also known as shank1-shank3 respectively)...
  49. ncbi Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus
    Seong Ho Park
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Acta Crystallogr D Biol Crystallogr 58:1353-5. 2002
    ..The PDZ domain of Shank binds to the C-terminus of guanylate kinase-associated protein (GKAP). The PDZ domain of Shank1 from Rattus norvegicus and its complex with the C-terminal octapeptide of GKAP were crystallized at 294 K using ..
  50. pmc Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton
    P M Okamoto
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 276:48458-65. 2001
    ..These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover...
  51. ncbi Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin
    T M Bockers
    Arbeitsgruppe Molekulare Neurobiologie, Institut fur Anatomie, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    J Biol Chem 276:40104-12. 2001
    ..We used the N-terminal ankyrin repeats of Shank1 and -3 to search for interacting proteins by yeast two-hybrid screening and by affinity chromatography...
  52. ncbi Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Japan SORST, Japan Science and Technology Corporation, Tokyo 113 0033, Japan
    Mol Cell Neurosci 26:330-41. 2004
    ..b>Shank1 and Shank2 proteins as well as GluRdelta2 proteins were localized in the dendritic spines of cultured Purkinje ..
  53. ncbi Identification of proteins interacting with the rat somatostatin receptor subtype 2
    H J Kreienkamp
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Germany
    J Physiol Paris 94:193-8. 2000
    Using the yeast two hybrid system we have identified a novel protein termed somatostatin receptor interacting protein (SSTRIP) from human brain which interacts with the rat somatostatin receptor subtype 2...
  54. ncbi The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins
    H J Kreienkamp
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 275:32387-90. 2000
    ..and -2 and the PSD-95/discs large/ZO-1 (PDZ) domain of a recently discovered multidomain protein family (ProSAP/SSTRIP/Shank) present in human and rat brain...
  55. ncbi The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family
    S Tobaben
    Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Biol Chem 275:36204-10. 2000
    ..b>Shank1 and CL1 are expressed primarily in brain, and both proteins co-enrich in the postsynaptic density...
  56. ncbi The Shank family of scaffold proteins
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Cell Sci 113:1851-6. 2000
    ..The specific localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions...
  57. ncbi Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    Genes Cells 5:203-10. 2000
    ..SAPAP also binds the recently identified proteins, nArgBP2 and synamon (also called Shank 1a), via the proline-rich region and the C-terminus, respectively...
  58. ncbi Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development
    S Lim
    Department of Pharmacology, Pusan National University, Kumjeong Ku, Pusan 609 735, Korea
    J Biol Chem 274:29510-8. 1999
    b>Shank1, Shank2, and Shank3 constitute a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD)...
  59. ncbi Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein
    I Yao
    Takai Biotimer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 274:27463-6. 1999
    ..We have identified here a novel neuronal GKAP/SAPAP/DAP-binding protein and named it synamon. Synamon has seven ankyrin repeats at the NH(2) terminus followed by one src homology 3 domain and one PSD-95/Dlg-..
  60. ncbi Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    J C Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 23:583-92. 1999
    ..Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors...
  61. ncbi Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95
    Mio Nonaka
    Department of Biophysics, Kyoto University Graduate School of Science, Kyoto 606 8502, Japan
    J Neurosci 26:763-74. 2006
    ..was significantly impaired, whereas the clustering of other scaffolding proteins, such as Homer 1c, Shank/Synamon, and PSD-93/Chapsin-110 was spared...
  62. doi Newly identified tumor-associated role of human Sharpin
    Jinyoung Jung
    Department of Microbiology, Chungnam National University, Daejeon 305 764, Korea
    Mol Cell Biochem 340:161-7. 2010
    ..Although rat Sharpin is reported to interact with Shank1, a multidomain scaffold protein localized in postsynaptic densities, its exact roles are unknown...
  63. ncbi Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton...
  64. pmc Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities
    Janin Schütt
    Institute for Human Genetics, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Biol Chem 284:25479-87. 2009
    ..Whereas the levels of several PSD components are unchanged, concentrations of Shank1 and SAPAP scaffold proteins and various glutamate receptor subunits are altered in both adult and juvenile knock-..
  65. pmc Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways
    Francesco Roselli
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e6011. 2009
    ..glutamate receptor trafficking, we now show that Abeta also disrupts two other scaffold proteins, Homer1b and Shank1, that couple PSD-95 with ionotropic and metabotropic glutamate receptors...
  66. ncbi [Effect of GEPT extracts on spatial learning ability of APPV717I transgenic mice at early stage of dementia and its possible mechanism]
    Leiming Zhang
    Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 34:428-32. 2009
    ..To investigate the effect of GEPT extracts on spatial learning ability of the APPV717I transgenic mice at the early stage of dementia and its possible mechanism...
  67. doi Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization
    Karima Azdad
    Laboratory of Neurophysiology, Universite Libre de Bruxelles, Brussels, Belgium
    Neuropsychopharmacology 34:972-86. 2009
    ..3a calcium channel activity through interactions with scaffold proteins Shank1/3...
  68. pmc Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1
    Albert Y Hung
    The Institute of Physical and Chemical Research RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:1697-708. 2008
    ..Here, we report the phenotype of Shank1 knock-out mice...
  69. ncbi DNA methylation regulates tissue-specific expression of Shank3
    Silvana Beri
    E Medea Scientific Institute, Bosisio Parini, LC, Italy
    J Neurochem 101:1380-91. 2007
    ..SHANK3, together with its homologues SHANK1 and SHANK2, has a central functional and structural role in excitatory synapses and is involved in the human ..
  70. pmc Activity induced changes in the distribution of Shanks at hippocampal synapses
    J H Tao-Cheng
    Electron Microscopy EM Facility, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, MD, USA
    Neuroscience 168:11-7. 2010
    ..Application of sub-type specific antibodies shows that Shank2 is typically concentrated at and near PSDs while Shank1 is, in addition, distributed throughout the spine head...
  71. pmc Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission
    Gareth M Thomas
    Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:15006-11. 2005
    ..These results suggest that binding of RSK2 to PDZ domain proteins and phosphorylation of these proteins or their binding partners regulates excitatory synaptic transmission...
  72. ncbi The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms
    Sonia Fieulaine
    Institut de Biologie Structurale J P Ebel CEA CNRS UJF, UMR5075, Laboratoire de Cristallographie et Cristallogenèse des Protéines LCCP GSY, 41 rue Jules Horowitz, F 38027 Grenoble Cedex 1, France
    J Biol Chem 280:42315-24. 2005
    ..Finally, these modified substrate binding pockets modify the position of the substrate in the active site. These differences provide guidelines for the design of bacterial PDF inhibitors that will not target mitochondrial PDFs...
  73. ncbi Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons
    Carlo Sala
    Cellular and Molecular Pharmacology Section, Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 25:4587-92. 2005
    ..The specificity of these translocations was demonstrated by their inhibition by both a Shank1 fragment and the dominant-negative Homer1a...
  74. ncbi A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins...
  75. ncbi C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3
    Tobias M Boeckers
    Institute of Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Neurochem 92:519-24. 2005
    ..In contrast to Shank1, expression of green-fluorescent protein (GFP)-tagged ProSAP1/Shank2 and ProSAP2/Shank3 deletion constructs in ..
  76. ncbi Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180
    Arne Quitsch
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitätskrankenhaus Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 25:479-87. 2005
    ..of the postsynaptic density in excitatory synapses interacts with the postsynaptic scaffold protein shank (shank1-3)...
  77. ncbi A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses
    Stefano Romorini
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 24:9391-404. 2004
    ..We investigated the molecular mechanisms of Shank1 targeting and synapse assembly by looking at the function of guanylate kinase-associated protein (GKAP) and PSD-95 ..
  78. ncbi The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin
    Guido Meyer
    Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Deutsche Forschungsgemeinschaft Centre for Molecular Physiology of the Brain, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Neuropharmacology 47:724-33. 2004
    ..Neuroligin binds to the PDZ domain-containing proteins PSD95, SAP102, Chapsyn110, S-SCAM, Magi1 and 3, Shank1 and 3, Pick1, GOPC, SPAR, Semcap3 and PDZ-RGS3...

Research Grants2

  1. Guoping Feng; Fiscal Year: 2016
    ..One of the most promising ASD candidate genes is Shank3. Shank family proteins (Shank1-3) directly bind SAPAP to form the PSD95/SAPAP/Shank complex...
  2. Activity-Dependent Regulation of Synapses by Shank
    ALBERT HUNG; Fiscal Year: 2005
    ..Finally, a genetic approach, generation of a Shank1 "knockout" mouse, will be used to investigate the role of Shank proteins in brain development, in postsynaptic ..