SH2B2

Summary

Gene Symbol: SH2B2
Description: SH2B adaptor protein 2
Alias: APS, SH2B adapter protein 2, SH2 and PH domain-containing adapter protein APS, adapter protein with pleckstrin homology and Src homology 2 domains
Species: human

Top Publications

  1. ncbi Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibition
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 284:30-4. 1991
  2. ncbi [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]
    G Schultze-Werninghaus
    , Abt. f. Pneumologie, Frankfurt/Main
    Pneumologie 45:729-33. 1991
  3. ncbi Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats
    I Prieto
    Unit of Physiology, , Bldg. B3, 23071, , Spain
    Horm Metab Res 33:559-63. 2001
  4. ncbi Artificial pulmonary surfactant as a carrier for intratracheally instilled insulin
    Ying Ji
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 28:744-50. 2007
  5. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
  6. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
  7. ncbi Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives
    T Baptista
    Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
    Pharmacopsychiatry 35:205-19. 2002
  8. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
  9. doi Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus
    Adriana Danowski
    Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
    J Rheumatol 36:1195-9. 2009
  10. pmc Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49
    C Thollon
    Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 112:37-42. 1994

Research Grants

  1. ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSIS
    Reginald Chukwuocha; Fiscal Year: 2000
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
  3. Emilio B Gonzalez; Fiscal Year: 2014
  4. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
  5. THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROME
    MARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004
  6. Chieko Mineo; Fiscal Year: 2014
  7. NOVEL BIOMARKERS FOR MECHANISTIC DIAGNOSIS OF THE ANTIPHOSPHOLIPID SYNDROME
    JACOB RAND; Fiscal Year: 2010
  8. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
  9. TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROME
    JOHN DEDMAN; Fiscal Year: 2003
  10. ANTIPHOSPHOLIPID SYNDROME REGISTRY (APSCORE)
    Robert Roubey; Fiscal Year: 2000

Detail Information

Publications451 found, 100 shown here

  1. ncbi Adenosine-5'-phosphosulfate kinase from Penicillium chrysogenum: ligand binding properties and the mechanism of substrate inhibition
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Arch Biochem Biophys 284:30-4. 1991
    35S]Adenosine-5'-phosphosulfate (APS) binding to Penicillium chrysogenum APS kinase was measured by centrifugal ultrafiltration...
  2. ncbi [Comparison of the characteristics of methacholine and of propranolol in the assessment of aspecific hyperreactivity of the airways]
    G Schultze-Werninghaus
    , Abt. f. Pneumologie, Frankfurt/Main
    Pneumologie 45:729-33. 1991
    ..The aerosol was administered by a dosimeter (APS, Jaeger), using doubling concentrations, with a maximum of 25 mg/ml (2.5%), the lowest concentrations being 0...
  3. ncbi Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats
    I Prieto
    Unit of Physiology, , Bldg. B3, 23071, , Spain
    Horm Metab Res 33:559-63. 2001
    ..Given that aminopeptidases (APs) play a major role in the metabolism of local peptides involved in blood pressure control, studying them helped us ..
  4. ncbi Artificial pulmonary surfactant as a carrier for intratracheally instilled insulin
    Ying Ji
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 28:744-50. 2007
    ..bioavailabilities and effects on lung injury alleviation of 4 insulin- artificial pulmonary surfactant (INS-APS) preparations were studied in normal rats...
  5. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    ..j.p.) followed by e.j.p. with superimposed action potentials (APs) and contraction. Addition of either NG-nitro-L-arginine (L-NOARG, 0.1 mM) or apamin (0...
  6. ncbi In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus
    J M Geraci
    Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine 77030, USA
    J Gen Intern Med 10:307-14. 1995
    ..9%). Patient age, the presence of comorbid diseases, and the Acute Physiology Score (APS) of APACHE II were associated with complication occurrence...
  7. ncbi Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives
    T Baptista
    Los Andes University School of Medicine, Department of Physiology, Merida, Venezuela
    Pharmacopsychiatry 35:205-19. 2002
    Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs)...
  8. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
    The association of antiphospholipid (aPL) antibodies with thrombosis in patients with antiphospholipid syndrome (APS) is well documented in humans and in animal studies...
  9. doi Determinants of risk for venous and arterial thrombosis in primary antiphospholipid syndrome and in antiphospholipid syndrome with systemic lupus erythematosus
    Adriana Danowski
    Rheumatology Department, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore MD 21205, USA
    J Rheumatol 36:1195-9. 2009
    Antiphospholipid syndrome (APS) is characterized by thrombosis (venous and arterial) and pregnancy loss in conjunction with the lupus anticoagulant, IgG or IgM anticardiolipin, or IgG or IgM anti-beta2-glycoprotein I...
  10. pmc Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49
    C Thollon
    Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 112:37-42. 1994
    ..Intracellular recordings of action potentials (APs) were performed with conventional glass microelectrodes. 2...
  11. ncbi Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilation
    I J MacRae
    Section of Molecular and Cellular Biology and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 40:6795-804. 2001
    ..7 kDa subunits (573 residues). The C-terminal allosteric domain of each subunit is homologous to APS kinase...
  12. ncbi Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency
    K V Venkatachalam
    Department of Biochemistry, College of Medical Sciences, Health Professions Division, Nova Southeastern University, 3200 South University Dr, Ft Lauderdale, FL 33328 2018, USA
    IUBMB Life 55:1-11. 2003
    ..First inorganic sulfate combines with ATP to form adenosine 5'-phosphosulfate (APS) and pyrophosphate catalyzed by ATP sulfurylase domain and in the second step, APS combines with another molecule ..
  13. doi Complement activation in patients with primary antiphospholipid syndrome
    K Oku
    Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Rheum Dis 68:1030-5. 2009
    To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS).
  14. ncbi Indoor air pollution by alkylphenols in Tokyo
    I Saito
    Department of Environmental Health and Toxicology, Division of Environment Health, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
    Indoor Air 14:325-32. 2004
    The purposes of this study were to develop an analytical method for airborne alkylphenols (APs) using the gas chromatography/mass spectrometry (GC/MS)-SIM method and to investigate airborne C4-C9 APs pollution in houses, offices, and ..
  15. ncbi Cross-reactivity between anti-cardiolipin, anti-high-density lipoprotein and anti-apolipoprotein A-I IgG antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome
    J Delgado Alves
    Centre for Rheumatology, Department of Medicine, University College London, London, UK
    Rheumatology (Oxford) 42:893-9. 2003
    ..important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of autoantibodies directed against plasma lipoproteins...
  16. ncbi Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction
    Corrado Betterle
    Chair of Clinical Immunology and Allergy, Department of Medical and Surgical Sciences, University of Padova, I 35128, Padova, Italy
    Endocr Rev 23:327-64. 2002
    ..Furthermore, the autoimmune polyglandular syndromes (APS) associated with AD (revised classification, animal models, genetics, natural history) have been discussed...
  17. ncbi Manipulation of thiol contents in plants
    R Höfgen
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Federal Republic of Germany
    Amino Acids 20:291-9. 2001
    ..relatively inert sulfate molecule is activated through binding to ATP forming adenosine-5'-phosphosulfate (APS). This enzymatic step is controlled through the enzyme ATP-sulfurylase (ATP-S)...
  18. ncbi Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population
    Kozo Hashimoto
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan
    Horm Res 64:253-60. 2005
    ..However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III).
  19. doi Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I
    Antonella Meloni
    Pediatric Clinic II, Ospedale Microcitemico and Dipartimento di Sciencze Biomediche e Biotechno logiche, University of Cagliari, Cagliari, Sardinia, Italy
    J Clin Endocrinol Metab 93:4389-97. 2008
    In autoimmune polyendocrinopathy syndrome type I (APS-I), mutations in the autoimmune regulator gene (AIRE) impair thymic self-tolerance induction in developing T cells...
  20. ncbi Non-radioactive adenosine 5'-phosphosulfate sulfotransferase assay by coupling with sulfite reductase and O-acetylserine(thiol)lyase
    T Ara
    Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan
    Biosci Biotechnol Biochem 61:621-4. 1997
    Adenosine 5'-phosphosulfate (APS) sulfotransferase is thought to be an enzyme that transfers the sulfo-group of APS to a carrier compound with a thiol group in the assimilatory sulfate reduction pathway of higher plants...
  21. doi Photo degradation of methyl orange an azo dye by advanced Fenton process using zero valent metallic iron: influence of various reaction parameters and its degradation mechanism
    L Gomathi Devi
    Department of Post Graduate Studies in Chemistry, Central College City Campus, Bangalore University, Bangalore, India
    J Hazard Mater 164:459-67. 2009
    ..of various reaction parameters like effect of iron dosage, concentration of H(2)O(2)/ammonium per sulfate (APS), initial dye concentration, effect of pH and the influence of radical scavenger are studied and optimum conditions ..
  22. doi Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome?
    Troy D Jaskowski
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States
    Clin Chim Acta 410:19-24. 2009
    To clarify the association and diagnostic utility of measuring antiphosphatidyl serine (aPS), antiprothrombin (aPT) and the antiphosphatidyl serine/prothrombin complex (aPS/PT) antibodies in patients with antiphospholipid syndrome (APS) ..
  23. ncbi [Severe neurological and obstetrical complications in a patient with antiphospholipid syndrome]
    Danuta Bobrowska-Snarska
    Klinika Reumatologii Pomorskiej AM w Szczecinie
    Pol Arch Med Wewn 115:457-62. 2006
    Antiphospholipd syndrome (APS) is a disease characterised by venous and arterial thrombosis or recurrent foetal loss, which are associated with antiphospholipid antibodies or/and lupus anticoagulant...
  24. pmc Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex
    H J Koester
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 529:625-46. 2000
    ..Single APs and trains of APs reliably evoked Ca2+ transients in en passant boutons located on axon collaterals in cortical ..
  25. pmc Homology modeling of dissimilatory APS reductases (AprBA) of sulfur-oxidizing and sulfate-reducing prokaryotes
    Birte Meyer
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    PLoS ONE 3:e1514. 2008
    The dissimilatory adenosine-5'-phosphosulfate (APS) reductase (cofactors flavin adenine dinucleotide, FAD, and two [4Fe-4S] centers) catalyzes the transformation of APS to sulfite and AMP in sulfate-reducing prokaryotes (SRP); in sulfur-..
  26. ncbi Radiofrequency catheter ablation of right atriofascicular (Mahaim) accessory pathways guided by accessory pathway activation potentials
    J H McClelland
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190
    Circulation 89:2655-66. 1994
    BACKGROUND: Accessory pathways (APs) exhibiting "Mahaim fiber" physiology (antegrade conduction only, long conduction time, and decremental properties) often connect the lateral right atrium to the right bundle branch (right ..
  27. ncbi Specificity and sensitivity of anti-beta2-glycoprotein I as compared with anticardiolipin antibody and lupus anticoagulant in Thai systemic lupus erythematosus patients with clinical features of antiphospholipid syndrome
    Virunya Parkpian
    Division of Allergy, Immunology and Rheumatology, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Clin Rheumatol 26:1663-70. 2007
    ..I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC)...
  28. ncbi Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains
    Eric B Lansdon
    Department of Chemistry and Section of Molecular and Cellular Biology, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 43:4356-65. 2004
    ..with each 71 kDa subunit containing an adenosine triphosphate (ATP) sulfurylase and an adenosine 5'-phosphosulfate (APS) kinase domain, catalyzes the overall formation of PAPS from ATP and inorganic sulfate...
  29. ncbi The use of portable computer for information acquirement during anesthesiologist's ward round in acute pain service
    Yung Lung Lee
    Department of Anesthesiology, Changhua Christian Hospital, Taiwan, ROC
    Acta Anaesthesiol Taiwan 45:79-87. 2007
    ..This study was to evaluate the use of PDA for acute pain assessment and compare the PDA-based method with that of the current paper-transcription method in work efficiency...
  30. ncbi [Ocular manifestations in patients with systemic lupus erythematosus and antiphospholipid syndrome]
    Lidia Ostanek
    Klinika Reumatologii, Pomorska Akademia Medyczna, Szczecin
    Pol Arch Med Wewn 117:18-23. 2007
    ..It could be the reason for many organs and tissues impairment. Changes in eyes that occurr in SLE are not frequent, but can lead to severe impairment of sight including blindness...
  31. pmc The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women
    D Le Thi Thuong
    Departments of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Ann Rheum Dis 64:273-8. 2005
    To study the characteristics of the haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in the antiphospholipid syndrome (APS) and its influence on the subsequent pregnancies.
  32. pmc Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50
    Minnie Rangarajan
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
    J Bacteriol 190:2920-32. 2008
    We previously described a cell surface anionic polysaccharide (APS) in Porphyromonas gingivalis that is required for cell integrity and serum resistance...
  33. doi Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
    Clin Chem Lab Med 49:447-61. 2011
    The antiphospholipid syndrome (APS) is an autoimmune condition characterised by a wide range of clinical features (primarily thrombosis and/or obstetric related), associated with the presence of antiphospholipid antibodies (aPL) as ..
  34. ncbi A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
    J Autoimmun 22:217-25. 2004
    ..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
  35. doi Novel sequence variation of AIRE and detection of interferon-omega antibodies in early infancy
    Beáta Tóth
    Department of Infectious and Pediatric Immunology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Clin Endocrinol (Oxf) 72:641-7. 2010
    Autoimmune polyendocrine syndrome type I (APS I) is a rare primary immunodeficiency disorder characterized by chronic mucocutaneous candidiasis, multi-organ autoimmunity and ectodermal dysplasia...
  36. doi Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2-) production by coelomocytes from sea cucumber Apostichopus japonicus in vitro
    Yongxin Sun
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, 116024, People s Republic of China
    Comp Biochem Physiol C Toxicol Pharmacol 147:293-8. 2008
    The potential immunostimulatory effects of Astralagus membranaceus polysaccharides (APS) on sea cucumber, Apostichopus japonicus (Selenka), were investigated in vitro...
  37. ncbi Increased platelet deposition on extracellular matrix under flow conditions in patients with antiphospholipid syndrome who experience thrombotic events
    Yair Levy
    Meir Medical Center, Kfar Saba, Israel
    Arthritis Rheum 52:4011-7. 2005
    To assess platelet function under defined flow conditions in patients with antiphospholipid syndrome (APS) and to correlate the results with thrombotic complications and the presence of subsets of antiphospholipid antibodies (aPL), lupus ..
  38. ncbi Sulfate-activating enzymes of Penicillium chrysogenum. The ATP sulfurylase.adenosine 5'-phosphosulfate complex does not serve as a substrate for adenosine 5'-phosphosulfate kinase
    F Renosto
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    J Biol Chem 264:9433-7. 1989
    At a noninhibitory steady state concentration of adenosine 5'-phosphosulfate (APS), increasing the concentration of Penicillium chrysogenum ATP sulfurylase drives the rate of the APS kinase-catalyzed reaction toward zero...
  39. ncbi Phase relation changes between the firings of alpha and gamma-motoneurons and muscle spindle afferents in the sacral micturition centre during continence functions in brain-dead human and patients with spinal cord injury
    G Schalow
    Electromyogr Clin Neurophysiol 50:3-27. 2010
    1. Single-nerve fibre action potentials (APs) were recorded with 2 pairs of wire electrodes from lower sacral nerve roots during surgery in patients with spinal cord injury and in a brain-dead human...
  40. ncbi The antiphospholipid syndrome in pregnant rabbits and their offspring. Neuropathological aspects
    Przemysław Nowacki
    Department of Neurology, Pomeranian Medical University, Szczecin, Poland
    Folia Neuropathol 43:15-22. 2005
    Although the obstetric consequences of antiphospholipid syndrome (APS) in pregnant rabbits have been described, there are no data on the serological and neuropathological aspects of the syndrome in their offspring...
  41. pmc Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosis
    D Paran
    Department of Rheumatology, Tel Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Ann Rheum Dis 65:525-8. 2006
    The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically.
  42. ncbi [Effects of Astragalus polysaccharides and Cordyceps sinensis mycelium mixture on the transforming growth factor-beta1 expression in chronic rejection of artery transplantation: experiment with rats]
    Song Zhao
    Department of General Surgery, First Affiliated Hospital, Harbin Medical University, Heilongjiang Province, Harbin 150001, China
    Zhonghua Yi Xue Za Zhi 87:851-4. 2007
    To explore the effect of Astragalus polysaccharides (APS) and Cordyceps sinensis (CP) mycelium mixture on the chronic rejection of artery transplantation.
  43. ncbi The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase
    H Li
    Department of Pediatrics, University of Chicago, Illinois 60637, USA
    J Biol Chem 270:29453-9. 1995
    ..action of two enzyme activities: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, and APS kinase, which subsequently phosphorylates APS to produce adenosine 3'-phosphate ..
  44. ncbi Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum
    Eric B Lansdon
    Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 41:13672-80. 2002
    Adenosine 5'-phosphosulfate (APS) kinase catalyzes the second reaction in the two-step, ATP-dependent conversion of inorganic sulfate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS)...
  45. ncbi A cost-utility and cost-effectiveness analysis of an acute pain service
    Michaela Stadler
    Department of Anesthesiology, University Hospital Center, Charleroi, Belgium
    J Clin Anesth 16:159-67. 2004
    To analyze, from a societal perspective, the cost-effectiveness and cost-utility of acute pain management after inception of a nurse-based Acute Pain Service (APS) in a general hospital.
  46. ncbi Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome
    Maria G Tektonidou
    Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Arthritis Rheum 50:2569-79. 2004
    To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL.
  47. ncbi Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies
    R R Forastiero
    Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
    Lupus 14:129-36. 2005
    The antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies (aPL) in patients with thromboembolic complications...
  48. ncbi Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats
    Shuang Suo Dang
    Department of Infectious Diseases, The Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi, China
    Chin Med J (Engl) 121:1010-4. 2008
    Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides (APS) in a rat model of chronic hepatic injury.
  49. doi An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomy
    Chantal Frigon
    Department of Anesthesiology, McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
    Paediatr Anaesth 19:1213-9. 2009
    ..The aim of the study was to evaluate the impact of having an organized acute pain service (APS) on postoperative pain management of these children.
  50. doi A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
    W Cao
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, 169 West Changle Road, Xi an, Shaanxi 710032, China
    Phytomedicine 17:598-605. 2010
    A novel polysaccharide isolated from Angelica sinensis, named APS-1d showed cytotoxic activity towards several cancer cell lines in vitro. However, the precise antitumor mechanisms of this compound are unknown...
  51. ncbi Arterialisation of the portal vein as a model for the induction of hepatic fibrosis: description of microsurgical models in the rat
    Volker Muller
    Department of Surgery, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Transpl Int 17:822-33. 2005
    ..inserted in the right renal artery (PVA-B), the second with unrestricted flow using an aortic-portal segment (PVA-APS). The third technique was orthotopic liver transplantation with unrestricted portal arterialisation (OLTx-APS)...
  52. ncbi Factor XIII in primary antiphospholipid syndrome
    Paul R J Ames
    Academic Department of Rheumatology, Leeds General Infirmary, Leeds, UK
    J Rheumatol 32:1058-62. 2005
    To evaluate the clinical significance of factor XIII (FXIII) in primary antiphospholipid syndrome (APS).
  53. ncbi Clusters of disease manifestations in patients with antiphospholipid syndrome demonstrated by factor analysis
    I Krause
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Israel
    Lupus 16:176-80. 2007
    The antiphospholipid syndrome (APS) is now recognized as a multi-system disease, the clinical expression of which may include various target-organs involvements...
  54. ncbi Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice
    W Chen
    Department of Geriatrics, Huashan Hospital, Fudan University of Shangai, China
    Exp Clin Endocrinol Diabetes 116:468-74. 2008
    ..Astragalus polysaccharides (APS) are bioactive components extracted from one of the traditional Chinese herbs, used to enhance the function of ..
  55. pmc Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals
    Mary J Palmer
    Neuroscience Group, Institute for Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
    J Physiol 572:747-62. 2006
    ..They do not fire Na(+)-dependent action potentials (APs) but the Mb1 class of goldfish bipolar cell exhibits Ca(2+)-dependent APs and regenerative potentials that ..
  56. ncbi Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin
    Yao Hsu Yang
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:1674-80. 2009
    We previously reported that some human antiphospholipid Abs (aPL) in patients with the antiphospholipid syndrome (APS) bind to the homologous enzymatic domains of thrombin and the activated coagulation factor X (FXa)...
  57. ncbi Use of a new silica clotting time for diagnosing lupus anticoagulant in patients who meet the clinical criteria for antiphospholipid syndrome
    Panagiotis Grypiotis
    Rheumatology Unit, University of Padova, Padova, Italy
    J Clin Lab Anal 20:15-8. 2006
    ..a new commercial SCT for identifying LA in patients who meet the clinical criteria for antiphospholipid syndrome (APS), and its association with thrombotic events were evaluated here...
  58. ncbi Oligonucleotide model with non-identical complementary strands for chromatographic studies of structure-dependent photosusceptibility
    V N Potaman
    Department of Biology, George Mason University, Fairfax, VA 22030
    J Chromatogr A 690:65-70. 1995
    ..F6 and the ordinary antiparallel-stranded (aps) F5.F7 duplexes...
  59. ncbi The Arousability Predisposition Scale: validity and determinants of between-subject variability
    A J Saliba
    Australian National University
    J Gen Psychol 125:263-9. 1998
    Norms for the Arousability Predisposition Scale (APS; S. Coren, 1990) obtained from an Australian university sample are presented...
  60. ncbi Autoantibodies against aromatic L-amino acid decarboxylase identifies a subgroup of patients with Addison's disease
    A Söderbergh
    Department of Clinical Sciences, University Hospital, Uppsala, Sweden
    J Clin Endocrinol Metab 85:460-3. 2000
    ..AADC) are present in about 50 percent of sera from patients with autoimmune polyendocrine syndrome type I (APS I) but absent in sera from patients with different organ-specific autoimmune diseases, such as insulin-dependent ..
  61. ncbi Trigeminal somatosensory innervation of the head of a teleost fish with particular reference to nociception
    Lynne U Sneddon
    Roslin Institute, Welfare Biology, Roslin, Midlothian EH25 9PS, UK
    Brain Res 972:44-52. 2003
    ..Conduction velocity, amplitude and duration of the APs, afterhypolarisation amplitude and duration, as well as the maximum rate of depolarisation were measured for each ..
  62. ncbi Patterns of abnormal motor cortex excitability in atypical parkinsonian syndromes
    A A Kühn
    Department of Neurology, Charite, Humboldt University Berlin, 13353 Berlin, Augustenburger Platz 1, Germany
    Clin Neurophysiol 115:1786-95. 2004
    ..We hypothesised that these atypical parkinsonian syndromes (APS) will show distinctive patterns in their motor output upon transcranial magnetic stimulation (TMS) due to their ..
  63. ncbi Identification of c-kit-positive cells in the human prostate: the interstitial cells of Cajal
    A Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Arch Androl 51:345-51. 2005
    The prostate exhibits electric activity in the form of slow waves (SWs) and action potentials (APs)...
  64. ncbi An association between autoreactive antibodies and anti-interferon-beta antibodies in multiple sclerosis
    N Garg
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY, USA
    Mult Scler 13:895-9. 2007
    ..of antiphospholipid antibodies (APLA) including anti-phosphatidylethanolamine (APE), anti-phosphatidylserine (APS), and anti-cardiolipin (ACA) antibodies, and other ARAB, antinuclear and anti-neutrophilic cytoplasmic antibodies, ..
  65. doi Autoantibody explosion in antiphospholipid syndrome
    Yehuda Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    J Autoimmun 30:74-83. 2008
    Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss in the presence of antiphospholipid antibodies (aPL), mainly anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant...
  66. doi Synthesis of electromagnetic functionalized nickel/polypyrrole core/shell composites
    Ping Xu
    Department of Applied Chemistry, Harbin Institute of Technology, Harbin, China
    J Phys Chem B 112:10443-8. 2008
    ..chemical oxidative polymerization of pyrrole (Py) monomer in the presence of Ni powder, with ammonium persulfate (APS) as oxidant and citric acid (C6H8O7) as dopant...
  67. doi Hematopoietic stem cell transplantation for systemic lupus erythematosus, the antiphospholipid syndrome and bullous skin diseases
    Alberto M Marmont
    Divisione di Ematologia e Trapianto di Cellule Staminali, Azienda Ospedaliera Universitaria S Martino, Genoa, Italy
    Autoimmunity 41:639-47. 2008
    ..Similar encouraging results have been obtained in the primary antiphospholipid syndrome (APS) and in bullous disorders of the skin.
  68. ncbi [Clinical value of antibodies to lysobisphosphatidic acid in patients with primary antiphospholipid syndrome]
    S Olivieri
    Cattedra e U O C di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Padova, Padova, Italia
    Reumatismo 62:107-12. 2010
    ..value of anti-lysobisphosphatidic acid (anti-LBPA) antibodies in patients with primary antiphospholipid syndrome (APS), the sera of 140 primary APS patients were tested and compared with those of 70 control subjects affected with ..
  69. pmc Reciprocal regulation among miR395, APS and SULTR2;1 in Arabidopsis thaliana
    Gang Liang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan, PR China
    Plant Signal Behav 5:1257-9. 2010
    ..miR395 controls the sulfate concentration in the shoot by targeting three ATP sulfurylase genes (APS), which encode the first enzymes catalyzing sulfate activation in sulfur assimilation pathway...
  70. doi [Antiphospholipid antibodies and the risk of thrombosis: a comparative survey between chronic immune thrombocytopenia and primary antiphospholipid syndrome]
    G Moulis
    Service de Medecine Interne, Universite de Toulouse, Toulouse Cedex, France
    Rev Med Interne 32:724-9. 2011
    ..The risk of thrombosis in this subgroup of patients is debated. In parallel, thrombocytopenia is present in 22 to 42% of patients with antiphospholipid syndrome (APS).
  71. doi Subsensory galvanic vestibular stimulation augments arterial pressure control upon head-up tilt in human subjects
    Kunihiko Tanaka
    Department of Physiology, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Auton Neurosci 166:66-71. 2012
    ..1 mA below the somatosensory threshold diminished the decrease (0.3±0.7 mmHg). The APs of another 10 subjects were maintained or decreased by less than 5 mmHg without GVS at the onset of HUT (4±2 mmHg),..
  72. pmc Astragalus polysaccharides lowers plasma cholesterol through mechanisms distinct from statins
    Yunjiu Cheng
    Division of Cardiology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e27437. 2011
    To determine the efficacy and underlying mechanism of Astragalus polysaccharides (APS) on plasma lipids in hypercholesterolemia hamsters. The effect of APS (0...
  73. ncbi Toxicity of the xenoestrogen nonylphenol and its biodegradation by the alga Cyclotella caspia
    Yu Liu
    School of Environmental Science and Engineering, Sun Yat Sen University, Guangzhou 510275, China
    J Environ Sci (China) 25:1662-71. 2013
    Alkylphenols (APs), the breakdown products of alkylphenol polyethoxylates that are widely used as surfactants, have been proven to exert estrogenic effects...
  74. pmc Antimicrobial preservatives induce aggregation of interferon alpha-2a: the order in which preservatives induce protein aggregation is independent of the protein
    Regina L Bis
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 E Montview Blvd, C238, Aurora, CO 80045, United States
    Int J Pharm 472:356-61. 2014
    Antimicrobial preservatives (APs) are included in liquid multi-dose protein formulations to combat the growth of microbes and bacteria...
  75. doi Fabrication of nano-structured calcium silicate coatings with enhanced stability, bioactivity and osteogenic and angiogenic activity
    Xiuhui Wang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
    Colloids Surf B Biointerfaces 126:358-66. 2015
    ..calcium silicate (CaSiO3, CS) coatings on metal substrates was fabricated by combining atmosphere plasma spraying (APS) and hydrothermal technology (HT)...
  76. doi Initial clinical experience with a new low-profile thoracic endograft
    Germano Melissano
    Division of Vascular Surgery, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Electronic address
    J Vasc Surg 62:336-42. 2015
    The Zenith Alpha thoracic endograft (William Cook Europe, ApS, Bjaeverskov, Denmark) is a new low-profile thoracic endograft that has recently become commercially available in Europe...
  77. doi Genetic aspects of the antiphospholipid syndrome: An update
    Gian Domenico Sebastiani
    U O C Reumatologia, Ospedale San Camillo Forlanini, Roma, Italy Electronic address
    Autoimmun Rev 15:433-9. 2016
    Studies on the immunogenetic predisposition to antiphospholipid syndrome (APS) and on other non-genetic and epigenetic factors are summarised and discussed. Family studies suggest a genetic predisposition to APS...
  78. doi What is known about pediatric antiphospholipid syndrome?
    Pier Luigi Meroni
    a Rheumatology, Gaetano Pini Institute, Center of Pediatric Rheumatology, Chair of Rheumatology, University of Milan, Milan, Italy
    Expert Rev Hematol 9:977-85. 2016
    Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy morbidity associated with the persistent presence of antiphospholipid antibodies (aPL) including lupus anticoagulant (..
  79. pmc Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis
    Ji Heun Jeong
    Department of Anatomy, College of Medicine, Konyang University, Seo Gu, Daejeon 302 718, Republic of Korea
    Exp Ther Med 12:3021-3028. 2016
    ..An increase in the number of autophagosomes (APs) was demonstrated in the cortices of IF-treated rats, using immunofluorescence staining and transmission electron ..
  80. ncbi The role of tryptophans 371 and 395 in the binding of antibiotics and the transport of sugars by the D-galactose-H+ symport protein (GalP) from Escherichia coli
    T P McDonald
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, United Kingdom
    J Biol Chem 270:30359-70. 1995
    ..by either [4-3H]cytochalasin B or by 3-[125I]iodo-4-azidophenethyl-amido-7-O-succinyldesacetylforskolin ([125I]APS-forskolin)...
  81. ncbi Endogenously generated spontaneous spiking activities recorded from postnatal spiral ganglion neurons in vitro
    X Lin
    Section on Neurobiology, Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Los Angeles, CA 90057, USA
    Brain Res Dev Brain Res 119:297-305. 2000
    ..We recorded endogenously-generated spontaneous action potentials (APs) from postnatal spiral ganglion (SG) neurons of mouse in vitro...
  82. ncbi A generalized Hebbian rule for activity-dependent synaptic modifications
    T Kitajima
    Faculty of Engineering, Yamagata University, Japan
    Neural Netw 13:445-54. 2000
    ..on the interval between the onset of excitatory postsynaptic potentials (EPSPs) and postsynaptic action potentials (APs)...
  83. ncbi Competition between primary and non-primary relations during sentence comprehension
    J Pynte
    CNRS and Laboratoire Parole et Langage, University of Provence, Aix en Provence, France
    J Psycholinguist Res 30:569-99. 2001
    The four eye-tracking experiments reported examined the way in which Adjunct Predicates (APs) located at the beginning of French sentences of the type "Tired (feminine/masculine) of calling the woman (s/he) left the room" are interpreted ..
  84. ncbi Antiphospholipid syndrome: a survey of clinical characters in ten cases
    Li Hua Chen
    Department of Internal Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci 4:616-9. 2003
    To gain further understanding of the antiphospholipid syndrome(APS).
  85. ncbi [Association of -2548G/A functional polymorphism in the promoter region of leptin gene with antipsychotic agent-induced weight gain]
    Zhi Jun Zhang
    Department of Psychiatry and Clinical Science Center, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Yi Xue Za Zhi 83:2119-23. 2003
    To investigate whether the -2548G/A functional polymorphism in promoter region of leptin gene influencing weight gain following antipsychotic agents (APS) acute treatment in schizophrenic patients.
  86. ncbi Single spine Ca2+ signals evoked by coincident EPSPs and backpropagating action potentials in spiny stellate cells of layer 4 in the juvenile rat somatosensory barrel cortex
    Thomas Nevian
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, D 69120 Heidelberg, Germany
    J Neurosci 24:1689-99. 2004
    ..We conclude that the spines of L4 cells can act as sharply tuned detectors for patterns of APs occurring in the boutons of the afferents to L4 cells and the spines of L4 cell dendrites...
  87. ncbi Anti-beta2-glycoprotein I antibodies--when and how should they be measured?
    Guido Reber
    Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Thromb Res 114:527-31. 2004
    ..This proposition raised the issue of the association of abeta2GPI with APS clinical criteria (thrombosis and pregnancy morbidity)...
  88. pmc Suppression of pain by exposure of acupuncture points to polarized light
    Yuri P Limansky
    Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine
    Pain Res Manag 11:49-57. 2006
    According to clinical studies, the stimulation of acupuncture points (APs) by a variety of methods (eg, needles, pressure, etc) is an effective method for the treatment of many pain syndromes...
  89. pmc Crystallization and preliminary X-ray crystallographic analysis of the Escherichia coli outer membrane cobalamin transporter BtuB in complex with the carboxy-terminal domain of TonB
    David D Shultis
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:638-41. 2006
    ..3, b = 82.4, c = 122.6 angstroms). The asymmetric unit consists of a single BtuB-TonB complex. Data sets have been collected to 2.1 angstroms resolution at a synchrotron beamline (APS SER-CAT 22-ID).
  90. ncbi Association of HELLP syndrome with primary antiphospholipid syndrome--a case report
    Katalin Veres
    Cardiovascular Unit, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Clin Rheumatol 27:111-3. 2008
    ..Authors present the first Hungarian case of a young pregnant woman with the association of antiphospholipid syndrome (APS) and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome...
  91. pmc Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins
    Guibin Chen
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:345-55. 2008
    ..hES cell clones lacking a group of cell surface molecules, glycosyl-phosphatidyl-inositol-anchored proteins (GPI-APs)...
  92. doi Upgrade of the CATS sample changer on FIP-BM30A at the ESRF: towards a commercialized standard
    L Jacquamet
    Groupe Synchrotron GSY, Laboratoire de Cristallographie et Cristallogenèse des Protèines LCCP, Institut de Biologie Structurale J P Ebel, UMR5075 CEA CNRS University J Fourier, 38027 Grenoble Cedex 1, France
    J Synchrotron Radiat 16:14-21. 2009
    ..At present, CATS is installed at SLS (three systems), BESSY (one system), DLS (two systems) and APS (four systems for the LSCAT beamline)...
  93. ncbi Primary antiphospholipid antibody syndrome and autoimmune haemolytic anaemia--a rare combination
    Saera Suhail
    Rheumatology Department, Baqai Medical University, Nazimabad, Pakistan
    J Pak Med Assoc 59:413-4. 2009
    ..Antiphospholipid Antibody Syndrome (APS) with underlying SLE, however, has a well documented association with Coomb's positive Auoimmune Haemolytic Anaemia...
  94. doi Polyglandular autoimmune diseases in a dermatological clinical setting: vitiligo-associated autoimmune diseases
    Paolo Amerio
    Dept of Dermatology, University of Chieti Pescara, Chieti, Italy, Dept of Dermatology, Catholic University of the Sacred Heart, Rome, Italy
    Eur J Dermatol 20:354-8. 2010
    ..the diseases described in association with vitiligo there are the so-called autoimmune polyglandular syndromes (APS). Here we report 31 cases of APS diagnosed in 113 vitiligo patients, according to the newest classification...
  95. doi Dermatological manifestations of Hughes' antiphospholipid antibody syndrome
    C Frances
    Department of Dermatology Allergology, Hopital Tenon, Paris, France
    Lupus 19:1071-7. 2010
    The dermatological manifestations of antiphospholipid syndrome (APS) may be the presenting features of APS syndrome...
  96. pmc Electrophysiological characteristics of globus pallidus neurons
    Jenia Bugaysen
    The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    PLoS ONE 5:e12001. 2010
    ..Extracellular recordings in primates revealed that in addition to differences in firing patterns the APs of neurons in these two groups have different widths (APex)...
  97. pmc HU protein affects transcription of surface polysaccharide synthesis genes in Porphyromonas gingivalis
    Christine Alberti-Segui
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Bacteriol 192:6217-29. 2010
    ..PG1136 to PG1143) encoding genes involved in synthesis of a surface-associated phosphorylated branched mannan (APS) indicated that this locus is also downregulated in the PG0121 mutant...
  98. doi 'Non-criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010
    M L Bertolaccini
    Lupus Research Unit, The Rayne Institute, King s College London School of Medicine, London, UK
    Lupus 20:191-205. 2011
    Abstract: Current classification criteria for definite APS recommend the use of one or more of three positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed ..
  99. pmc A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324)
    Khajamohiddin Syed
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e28286. 2011
    ..CYP5136A3 that showed common responsiveness and catalytic versatility towards endocrine-disrupting alkylphenols (APs) and mutagenic/carcinogenic polycyclic aromatic hydrocarbons (PAHs)...
  100. doi Seronegative antiphospholipid syndrome
    Rabih Nayfe
    Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11 0236, Riad El Solh, Beirut 1107 2020, Lebanon
    Rheumatology (Oxford) 52:1358-67. 2013
    b>APS is an autoimmune disease that leads to arterial and/or venous thrombosis, recurrent pregnancy loss and persistently positive aPLs...
  101. pmc Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis
    Chieko Mineo
    Department of Pediatrics, Division of Pulmonary and Vascular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Curr Rheumatol Rep 15:324. 2013
    The antiphospholipid syndrome (APS) is characterized by recurrent vascular thrombosis, thrombocytopenia, and fetal loss occurring in the presence of antiphospholipid antibodies (aPL)...

Research Grants74

  1. ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSIS
    Reginald Chukwuocha; Fiscal Year: 2000
    ..including recurrent thrombosis, fetal loss, thrombocytopenia and cerebral involvement ("Antiphospholipid syndrome", APS) in systemic lupus erythematous (SLE) are associated with the production of anticardiolipin antibodies (ACA) and ..
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
  3. Emilio B Gonzalez; Fiscal Year: 2014
    ..thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs...
  4. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    Patients with the antiphospholipid antibody syndrome (APS) have autoantibodies to certain phospholipids (aPL) such as cardiolipin and/or the lupus anticoagulant and clinically experience recurrent venous or arterial thrombosis, history ..
  5. THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROME
    MARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004
    DESCRIPTION: (Scanned from the applicant's description): APS is a disorder characterized by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies...
  6. Chieko Mineo; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The antiphospholipid syndrome (APS) is an autoimmune disease characterized by a markedly increased risk of thromboses and cardiovascular diseases resulting from elevated levels of circulating ..
  7. NOVEL BIOMARKERS FOR MECHANISTIC DIAGNOSIS OF THE ANTIPHOSPHOLIPID SYNDROME
    JACOB RAND; Fiscal Year: 2010
    ..and therapeutic responses for blood and vascular dysfunction - specifically, the antiphospholipid syndrome (APS) an autoimmune thrombotic condition that is reported to be responsible for ~10% of patients with venous ..
  8. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS)...
  9. TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROME
    JOHN DEDMAN; Fiscal Year: 2003
    Antiphospholipid Syndrome (APS), also known as Hughes Syndrome, is a multiorgan vascular disease associated with myocardial infarction, stroke thrombosis and recurrent fetal loss...
  10. ANTIPHOSPHOLIPID SYNDROME REGISTRY (APSCORE)
    Robert Roubey; Fiscal Year: 2000
    This contract is for a Registry and Repository for Antiphospholipid Syndrome (APS) that will enable investigators to identify basic immunological and genetic abnormalities, pathophysiological mechanisms contributing to thrombosis, fetal ..
  11. Natalia Beglova; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Antiphospholipid syndrome (APS) is an autoimmune disease characterized clinically by thrombosis and/or recurrent fetal loss...
  12. Mechanisms of aPL antibody-induced pregnancy loss
    Jane Salmon; Fiscal Year: 2005
    The antiphospholipid syndrome (APS), characterized by thrombosis and pregnancy loss that occurs in the presence of antiphospholipid (aPL) antibodies, is a leading cause of miscarriage and maternal and fetal morbidity...
  13. Anne Davidson; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: Antiphospholipid syndrome (APS) is a devastating autoimmune condition that causes recurrent blood clots and has no effective treatment apart from ..
  14. Mayris P Webber; Fiscal Year: 2014
    ..The following SAID diagnoses will be included: systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc;both diffuse and limited), inflammatory myositis (dermatomyositis, polymyositis, or ..
  15. Isolation of Autoantibodies to Apoptotic Cells
    Marko Radic; Fiscal Year: 2004
    ..evidence links the initiation and progression of Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Syndrome (APS) to aberrant immune responses to apoptotic cells...
  16. ANTIPHOSPHOLIPID ANTIBODIES AND DISORDERS OF PREGNANCY
    Neal Rote; Fiscal Year: 2000
    ..previous studies have demonstrated that mouse monoclonal and human polyclonal antiphosphatidylserine antibodies (aPS) bind directly to antigens on trophoblast, both villous and extravillous...
  17. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the phenotypic ..
  18. Role of P2Y Receptors and Activated Platelets in Inflammation
    ANALIA E GARCIA; Fiscal Year: 2012
    ..show that Clopidogrel treatment, that dampens platelet activation, aggravates the inflammatory responses in a PG-APS -induced arthritis in a rat model...
  19. Bernardo Rudy; Fiscal Year: 2015
    ..known as the fast-spiking (FS) cell, named for its ability to fire sustained trains of action potentials (APs) at remarkably high frequencies...
  20. Synaptic plasticity, EtOH and backpropagating action potentials in NAcc
    Gilles E Martin; Fiscal Year: 2010
    ..We hypothesize that LTD results from the interactions between synaptic potentials and backpropagating (b-APs), and that b-APs mediate EtOH effects on LTD...
  21. Gilles E Martin; Fiscal Year: 2016
    ..model of plasticity called Spike-Timing-Dependent Plasticity (STDP) that relies on pairing of action potentials (APs) and excitatory postsynaptic potentials (EPSP) at in vivo-like frequencies (~ 1Hz)...
  22. Jason M Christie; Fiscal Year: 2016
    ..are compiled at the soma, and are then transmitted to synaptic output sites on the axon as action potentials (APs) following initiation in the axon initial segment (AIS)...
  23. Taner Akkin; Fiscal Year: 2014
    ..We also utilized the technology for depth- localization of APs in axons stained with voltage-sensitive dyes, and constructed highly sensitivity polarization-sensitive systems for ..
  24. OPTO-ELECTRIC MAPPING OF ACTION POTENTIALS
    Igor R Efimov; Fiscal Year: 2013
    ..Alternatively, optical mapping technology permits recordings of tens of thousands of APs from the epicardium or endocardium, yet it has been used solely for in vitro studies and has not yet been ..
  25. Grant D Nicol; Fiscal Year: 2015
    ..demonstrated that NGF/BDNF can rapidly increase the ability of sensory neurons to fire action potentials (APs) via p75 neurotrophin receptor (p75NTR) activation of the sphingolipid signaling cascade...
  26. TEMPORAL PRECISION AND DYNAMICAL CODING IN THE OLFACTORY BULB
    Richard C Gerkin; Fiscal Year: 2012
    ..Because of this speed limit, the precise timing of action potentials (APs) will not track rapid, millisecond-timescale changes in stimulus properties as in other sensory systems...
  27. A method for diffraction-limited spot measurements of membrane potential in situ
    Thomas S Otis; Fiscal Year: 2013
    ..have limited photoxicity, and the speed and sensitivity required for detection of individual action potentials (APs) in single neurons...
  28. Antigen Identification in a Novel Model of Spontaneous Autoimmune Ovarian Disease
    Mickie H Cheng; Fiscal Year: 2012
    ..for the Autoimmune Regulator (AIRE) gene, a gene first identified in the human Autoimmune Polyglandular Syndrome (APS) type 1...
  29. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies...
  30. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    Recurrent pregnancy losses are a hallmark of the antiphospholipid syndrome (APS), a complicated major hypercoagulable disorder without an established mechanism that is currently diagnosed with phenomenologic surrogate tests...
  31. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
    The Antiphospholipid Syndrome (APS) represents an interface between the immune system and blood coagulation...
  32. ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
    Pojen Chen; Fiscal Year: 2007
    ..are to identify and characterize pathogenic anticardiolipin antibodies (aCL) in the antiphospholipid syndrome (APS)...
  33. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..This American Physiological Society (APS) conference will focus on many of these mechanisms...
  34. Diane J Mathis; Fiscal Year: 2015
    ..focuses on the molecular mechanisms of Aire, the protein encoded by the gene mutated in individuals with APECED (or APS-1), a primary immunodeficiency disease characterized by multi-organ autoimmunity...
  35. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
  36. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ..manner, and serve as bi-directional regulators of intrinsic excitability by limiting retrograde b-APs and electrotonic propagation of dendritic EPSPs...
  37. Role of ROS-Induced DNA Damage in Mitochondria-Regulated Apoptosis
    Anne Tann; Fiscal Year: 2012
    ..In addition to oxidatively damaging proteins and lipids, ROS also cause DNA damage, such as mutagenic abasic sites (APS) and their oxidized derivatives (OAS), in nuclear and mitochondrial DNA, which have implications for the induction ..
  38. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Here we will determine whether treatments that block (local APS or Map kinase inhibitors in Bla) or facilitate (D-cyclpserine given systemically or directly into Bla) will alter ..
  39. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  40. Structural Analysis of the GPI Transamidase Complex
    Anant K Menon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are ubiquitous in eukaryotes...
  41. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    We have shown that bacterial products (proteoglycan-polysaccharide, PG- APS) found in the lower bowel produce chronic granulomatous inflammation similar to Crohn's disease (regional ileitis) in genetically susceptible rats as well as ..
  42. Ann E Jerse; Fiscal Year: 2014
    ..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeability- increasing protein (BPI), kill Gc in vitro...
  43. Effects of K+ Accumulation/Depletion in the Heart
    Guy Salama; Fiscal Year: 2013
    ..In perfused hearts, APs and [K+]a will be simultaneously mapped, and changes in [K+]a will be measured on a beat-to-beat basis...
  44. Secretagogue induced mechanisms regulating islet electrical activity
    DAVID AARON JACOBSON; Fiscal Year: 2012
    ..whole islet current clamp recordings in combination with high speed calcium imaging to measure changes in APs and calcium fluctuations caused by glucose, GLP-1, and phosphatase regulation. 2...
  45. Nanoprobe for High Resolution Hard X-ray Fluorescence Microscopy
    Gayle E Woloschak; Fiscal Year: 2010
    ..installed at the beamline of the Life Sciences Collaborative Access Team (LS-CAT) at the Advanced Photon Source (APS) at Argonne National Laboratory (ANL)...
  46. Chemistry and Biology of Bacterial Sulfonucleotide Reductases
    KATE SUZANNE CARROLL; Fiscal Year: 2013
    ..cysteine biosynthesis, sulfonucleotide reductases (SRs) catalyze the reduction of 5'-phosphosulfoadenosine (APS) or 3'-phospho-5'phosphosulfoadenosine (PAPS) to sulfite using reducing equivalents from a protein ..
  47. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2009
    ..Purified cathepsin G (CG) and two antimicrobial peptides (APs) found within PMNs, LL37 and the bactericidal/permeabilityincreasing protein (BPI), kill Gc in vitro...
  48. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..Parenterally injected peptidoglycanpolysaccharide complexes (PG-APS) induce a systemic inflammatory response consisting of erosive polyarthritis, hepatic granulomas, and anemia...
  49. Kang Kim; Fiscal Year: 2014
    ..alternative imaging technique to non-invasively and reliably identify and characterize atherosclerotic plaques (APs)...
  50. Deaf1 isoforms control changes in PTA expression in the NOD PLN during T1D pathog
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..or a lack of regulatory T cell development? Finally, do either mouse models of autoimmune uveoretinitis or human APS 1 patients have changes in Deaf1 that can be correlated with disease? The results of these studies will provide an ..
  51. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John S Gunn; Fiscal Year: 2013
    ..A key component of the innate immune system in these locations are antimicrobial peptides (APs): ubiquitous proteins that destroy bacterial membranes. PhoP-PhoQ (PhoPQ) and PmrA-PmrB (PmrAB) are Salmonella spp...
  52. Directed hematopoietic differentiation of human pluripotent stem cells
    Linzhao Cheng; Fiscal Year: 2013
    ..and gives rise to large numbers of blood cells lacking glycosyl-phosphatidyl- inositol anchored proteins (GPI-APs)...
  53. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..specially developed high-speed readout by RMD and evaluated at the BioCAT beam line at the Advanced Photon Source (APS) at ANL, to demonstrate their performance superiority compared to current state-of-the- art scintillator screens...
  54. Alison K Criss; Fiscal Year: 2016
    ..animals other than humans and by the inability of PMN-derived cell lines to make many antimicrobial proteins (APs)...
  55. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..Optical maps of APs and Cai transients q selective blockers for IKr, IKs and ICa will elucidate gender differences in the spatial ..
  56. Bioactive Compounds from the Biodiversity of Vietnam and Laos
    Djaja D Soejarto; Fiscal Year: 2010
    ..These six APs will operate under the coordination of the GROUP PROGRAM based at UIC...
  57. Interactive Program to Manage and Prevent Back Pain
    A Blair Irvine; Fiscal Year: 2013
    ..NLBP) that does not require medical attention, the American College of Physicians (ACP) and American Pain Society (APS) recommend a multidisciplinary approach to pain management that integrates cognitive, physical, and educational ..
  58. Repair of Endogenous Damage in Mammalian Genomes
    Sankar Mitra; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mutagenic and toxic abasic sites (APS) and their oxidized derivatives (OAS), implicated in induction of sporadic cancer, are endogenously generated in the nuclear and mitochondrial genomes of ..
  59. Control Systems for Artificial Pancreas Use During and After Exercise
    Ali Cinar; Fiscal Year: 2013
    ..The project aims are to develop multivariable control and hypoglycemia early warning systems for APs that will be safe to use during and after various types of exercise and group sports for patients with diabetes, to ..
  60. Mechanisms of Sap-mediated Antimicrobial Peptide Resistance
    Margaret E Bauer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Antimicrobial peptides (APs), including defensins and cathelicidins, are an important component of the innate immune system for combating bacteria and other microbial invaders...
  61. Diane J Mathis; Fiscal Year: 2015
    ..Mutations in the AIRE gene underlie a rare multi-organ autoimmune disease called APECED or APS-1, and abnormalities in the Aire-pathway have also been implicated in certain of the more common autoimmune ..
  62. Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical Evaluation
    Howard Zisser; Fiscal Year: 2013
    ..a continuous glucose sensor, a continuous subcutaneous insulin infusion pump, and artificial pancreas software (APS)...
  63. BioCARS: A Synchroton Structural Biology Resource
    JOHN KEITH MOFFAT; Fiscal Year: 2011
    ..that exploits the distinctive features of BioCARS and complements other structural biology beamlines at the APS and nationally...
  64. Database designed novel anti-MRSA peptides
    Guangshun Wang; Fiscal Year: 2013
    ..we have been constructing, expanding, and updating the widely used Antimicrobial Peptide Database (APD;http://aps.unmc.edu/AP/main.html)...
  65. Marsha Lakes Matyas; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The APS STEP-UP project will help undergraduate students from groups underrepresented in biomedicine to 1) increase their understanding of and exposure to careers in biomedical research, 2) ..
  66. Stephan F Taylor; Fiscal Year: 2014
    ..Individuals with an 'attenuated psychosis syndrome'(APS) present with low levels of reality distortion (unusual thought content, perceptual aberrations, suspiciousness/..
  67. BioCARS: A Synchroton Structural Biology Resource
    JOHN KEITH MOFFAT; Fiscal Year: 2012
    ..that exploits the distinctive features of BioCARS and complements other structural biology beamlines at the APS and nationally...
  68. Eric A Wan; Fiscal Year: 2014
    ..The system consists of multiple wireless access points (APs) positioned throughout the home, an (optional) small wireless tag worn by the individual, a hub that aggregates the ..
  69. "Mixtures of Xenoestrogens Alter Estradiol-induced Non-Genomic Signaling"
    René Viñas; Fiscal Year: 2013
    ..Alkylphenols (APs;nonylphenol (NP) and the structurally related bisphenol-A (BPA)) are known XEs that have been detected in ..
  70. The Sexual Abuse of Vulnerable Adults in Institutions
    Pamela Teaster; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): In 2000, Adult Protective Services (APS), typically the state agency of first contact in cases of abuse, neglect, or exploitation, received 473,095 domestic (in the community) and institutional (..
  71. ANTIPROGESTINS IN ENDOMETRIUM
    RONALD WIEHLE; Fiscal Year: 2000
    ..and the NICHD was finalized to develop new 19-substituted-norprogestins. New antiprogestins (APs) discovered by NICHD and realized as drugs through this SBIR, would bring the results of government-sponsored ..
  72. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..Waggoner and Ernst will synthesize new longer wavelength fluorescent dyes to monitor action potentials (APs) or cytosolic free Ca2+(Cai) and Dr...