SFRP4

Summary

Gene Symbol: SFRP4
Description: secreted frizzled related protein 4
Alias: FRP-4, FRPHE, PYL, sFRP-4, secreted frizzled-related protein 4, frizzled protein, human endometrium, secreted frizzled-related protein 4; secreted frizzled-related protein 4
Species: human

Top Publications

  1. ncbi Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells
    Theresa J Berndt
    Division of Nephrology and Hypertension, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic Rochester, Mayo College of Medicine, MN, 55905, USA
    Pflugers Arch 451:579-87. 2006
  2. ncbi The phosphatonins and the regulation of phosphate transport and vitamin D metabolism
    Stacy Sommer
    Nephrology and Hypertension Research, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, MS 1 120, 200 First Street SW, Rochester, MN 55905, USA
    J Steroid Biochem Mol Biol 103:497-503. 2007
  3. ncbi Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
    Sze Chuen Cesar Wong
    Department of Biology, Hong Kong University of Science and Technology, Hong Kong, China
    J Pathol 196:145-53. 2002
  4. ncbi WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer
    Christoph Wissmann
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, 13347 Berlin, Germany
    J Pathol 201:204-12. 2003
  5. ncbi Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer
    Lisa G Horvath
    Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Australia
    Prostate 67:1081-90. 2007
  6. doi Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma
    E Jost
    Medizinische Klinik IV, Universitaetsklinikum Aachen, RWTH Aachen, Germany
    Cancer Lett 281:24-31. 2009
  7. ncbi Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours
    J Drake
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth
    Eur J Gynaecol Oncol 30:133-41. 2009
  8. pmc Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients
    Francis Jacob
    Translational Research Group, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e31885. 2012
  9. ncbi Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    Clin Cancer Res 10:615-25. 2004
  10. ncbi Evidence of genetic underexpression in chorionic villi samples of euploid fetuses with increased nuchal translucency at 10-11 weeks' gestation
    Antonio Farina
    Prenatal Medicine Unit, Embryology and Applied Biology, University of Bologna, Italy
    Prenat Diagn 26:128-33. 2006

Research Grants

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells
    Theresa J Berndt
    Division of Nephrology and Hypertension, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic Rochester, Mayo College of Medicine, MN, 55905, USA
    Pflugers Arch 451:579-87. 2006
    ..We conclude that sFRP-4 increases renal P(i) excretion by reducing Na(+)-P(i)-IIa transporter abundance in the brush border of the proximal tubule through enhanced internalization of the protein...
  2. ncbi The phosphatonins and the regulation of phosphate transport and vitamin D metabolism
    Stacy Sommer
    Nephrology and Hypertension Research, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, MS 1 120, 200 First Street SW, Rochester, MN 55905, USA
    J Steroid Biochem Mol Biol 103:497-503. 2007
    ..MEPE, however, increases circulating 1alpha,25(OH)(2)D. Circulating or local concentrations of these peptides/proteins may regulate 25-hydroxyvitamin D 1alpha-hydroxylase activity in renal tissues under physiologic circumstances...
  3. ncbi Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
    Sze Chuen Cesar Wong
    Department of Biology, Hong Kong University of Science and Technology, Hong Kong, China
    J Pathol 196:145-53. 2002
    ..This first systemic analysis of the Frp and the Wnt-signalling pathway in human breast cancer provides a springboard for further work on the role of Frp in the development of breast cancer...
  4. ncbi WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer
    Christoph Wissmann
    metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, 13347 Berlin, Germany
    J Pathol 201:204-12. 2003
    ..Three of these genes encode extracellular components of the Wnt pathway (WNT2, WIF1, SFRP4); two are receptors (FZD4, FZD6); two belong to the intracellular signal cascade (DVL1, PPP2CB); one regulates ..
  5. ncbi Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer
    Lisa G Horvath
    Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Australia
    Prostate 67:1081-90. 2007
    Secreted frizzled-related proteins (sFRP4) inhibits Wnt signaling and thus cellular proliferation in androgen-independent prostate cancer cells in vitro...
  6. doi Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma
    E Jost
    Medizinische Klinik IV, Universitaetsklinikum Aachen, RWTH Aachen, Germany
    Cancer Lett 281:24-31. 2009
    ..5% for SFRP1, 52.6% for SFRP2, 1.3% for SFRP4 and 6.9% for SFRP5...
  7. ncbi Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours
    J Drake
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth
    Eur J Gynaecol Oncol 30:133-41. 2009
    ..Secreted frizzled-related protein 4 (SFRP4) has been demonstrated to be involved in apoptosis in the ovary but not in ovarian tumours as yet...
  8. pmc Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients
    Francis Jacob
    Translational Research Group, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e31885. 2012
    ..Secreted frizzled-related protein 4 (SFRP4) has been proposed to have inhibitory activity through binding and sequestering Wnt ligands.
  9. ncbi Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
    Lisa G Horvath
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    Clin Cancer Res 10:615-25. 2004
    ..Secreted frizzled-related protein 4 (sFRP4) is a secreted protein with putative inhibitory activity of the Wnt-signaling cascade through binding and ..
  10. ncbi Evidence of genetic underexpression in chorionic villi samples of euploid fetuses with increased nuchal translucency at 10-11 weeks' gestation
    Antonio Farina
    Prenatal Medicine Unit, Embryology and Applied Biology, University of Bologna, Italy
    Prenat Diagn 26:128-33. 2006
    ..To retrospectively investigate whether the genetic profile from chorionic villous sampling (CVS) found in euploid fetuses with increased NT differs from matched controls...
  11. doi From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measures
    Melih C Boruban
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Eur J Cancer Prev 17:133-8. 2008
    ..In contrast, these abnormalities are not seen in patients who receive aromatase inhibitors and switched therapy after tamoxifen withdrawal may reverse tamoxifen-associated endometrial thickening...
  12. ncbi Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, 5th Floor MPRB, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:2373-84. 2005
    ..of the expression and function of an inhibitor of Wnt signaling, secreted frizzled-related protein 4 (sFRP4), during renal tubular epithelial injury initiated by unilateral ureteral obstruction (UUO)...
  13. ncbi Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women
    Khurram S Rehman
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Mol Hum Reprod 9:681-700. 2003
    ..inhibitor type 1 (PAI-1), milk fat globule-EGF factor 8 protein (MFGE8), secreted frizzled-related protein 4 (sFRP4) and estrogen receptor alpha (ERalpha). On the microarray these transcripts were up-regulated 7...
  14. ncbi Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass
    Rika Nakanishi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Bone Miner Res 23:271-7. 2008
    Transgenic mice overexpressing Sfrp4 in osteoblasts were established. These mice exhibited low bone mass caused by a decrease in bone formation.
  15. ncbi [Methylation status of CpG islands in secreted frizzled-related protein gene promoter region of malignant hematopoietic cell lines]
    Cheng Bo Xu
    Department of Hematology, Union Hospital, Fujian Medical University Fujian Institute of Hematology, Fuzhou 350001, Fujian Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1487-91. 2009
    ..for SFRP1 and 2 were present in nine malignant hematopoietic cell lines, however, methylation and unmethylation of SFRP4 were both detected in CA46, HL60 and U937 cell lines, and SFRP5 in U266 as well...
  16. doi Transgenic mice overexpressing secreted frizzled-related proteins (sFRP)4 under the control of serum amyloid P promoter exhibit low bone mass but did not result in disturbed phosphate homeostasis
    Hwa Young Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Bone 47:263-71. 2010
    Secreted frizzled-related protein-4 (sFRP4) is a member of secreted modulators of Wnt signaling pathways and has been recognized to play important role in the pathogenesis of oncogenic osteomalacia as a potential phosphatonin...
  17. ncbi Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas
    Andelko Hrzenjak
    Department of Pathology, Medical University, Graz, Austria
    J Pathol 204:19-27. 2004
    ..genes were those of secreted frizzled-related proteins (SFRPs), in particular secreted frizzled-related protein 4 (SFRP4)...
  18. pmc Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:783-96. 2007
    ..transforming growth factor beta inducible (Tgfb1), cyclin D1 (Ccnd1), and secreted frizzled-related protein 4 (Sfrp4)], selected for real-time RT-PCR analysis, correlated well with the directionality of the microarray data...
  19. pmc Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting
    Grace E Snow
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    BMC Cancer 9:383. 2009
    ..This study comprehensively investigated expression profiles of Wnt signalling components regulated during induced differentiation of EC cells and explored the role of key components in maintaining pluripotency...
  20. doi Parathyroid hormone signaling in bone and kidney
    Minnkyong Lee
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Curr Opin Nephrol Hypertens 18:298-302. 2009
    ..Here, we will review the recent advancements regarding PTH signaling in bone and kidney...
  21. ncbi Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy
    M Fujita
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Mol Endocrinol 28:213-23. 2002
    ..Seven independent clones were isolated and one of the up-regulated genes was secreted frizzled-related protein 4 (sFRP4)...
  22. ncbi The role of sFRP4, a secreted frizzled-related protein, in ovulation
    J M Drake
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, WA, Australia
    Apoptosis 8:389-97. 2003
    ..Many apoptosis related genes have been identified in the ovary. Secreted Frizzled Related Protein 4 (sFRP4) is a protein that appears to antagonize a molecular pathway for cell survival...
  23. ncbi Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice
    Rika Nakanishi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Bone Miner Res 21:1713-21. 2006
    We segregated a QTL for peak BMD on Chr 13 by generating congenic sublines of the senescence-accelerated mouse SAMP6. Sfrp 4 within this locus was responsible for lower BMD of SAMP6.
  24. ncbi Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
    Julie Bayle
    Department of Medicine, Rheumatology Section, Boston University School of Medicine, Arthritis Center, Boston, Massachusetts 02118, USA
    J Invest Dermatol 128:871-81. 2008
    ..beta-catenin (DACT1) and DACT2; Wnt-induced secreted protein 2; and secreted frizzled-related protein (SFRP)2 and SFRP4. RNase protection and northern blot confirmed microarray results...
  25. doi Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study
    Yunao Liu
    Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hum Reprod 25:479-90. 2010
    ..We investigated if aberrant expression of genes in the Wnt-signaling pathway may be involved...
  26. ncbi Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells
    Minnie Hsieh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:4597-606. 2003
    ..Therefore, regulation of sFRP-4 by LH and PRL may be important for modulating Fz-1, which is known to be expressed in periovulatory follicles, and Wnt-4/Fz-4, which are expressed in corpora lutea...
  27. ncbi Comparative genomics on Dkk1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 27:275-9. 2005
    ..FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, ROR1, ROR2, RYK, and also secreted proteins SFRP1, SFRP2, SFRP3, SFRP4, SFRP5, and DAND4 (CER1)...
  28. ncbi Comparative genomics on SFRP1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 27:861-5. 2005
    SFRP1, SFRP2, SFRP3, SFRP4, SFRP5, WIF1, DKK1, DKK2, DKK3, DKK4 are secreted-type WNT signaling modulators. SFRP1 tumor suppressor gene at human chromosome 8p11...
  29. ncbi Comparative genomics on SFRP2 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:783-7. 2005
    SFRP1, SFRP2, SFRP3, SFRP4, SFRP5, DKK1, DKK2, DKK3, DKK4, and WIF1 are soluble modulators of WNT signaling. SFRP2 gene at human chromosome 4q31...
  30. ncbi WNT antagonist, SFRP1, is Hedgehog signaling target
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:171-5. 2006
    ..within the promoter region of genes encoding secreted-type WNT signal inhibitors, including SFRP1, SFRP2, SFRP3, SFRP4, SFRP5, DKK1, DKK2, DKK3, DKK4, and WIF1...
  31. doi Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia
    Vanesa Martin
    Hematology Department, Reina Sofia Hospital, 14004 Cordoba, Spain
    Cancer Sci 99:1865-8. 2008
    ..significance of aberrant promoter methylation of the canonical Wnt pathway antagonist genes (sFRP1, sFRP2, sFRP4, sFRP5, Wif1, Dkk3, and Hdpr1) and also putative tumor-suppressor gene Wnt5a, belonging to the non-canonical Wnt ..
  32. pmc Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia
    Mashaal Dhir
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Gastrointest Surg 12:1745-53. 2008
    ..This study examined the role of epigenetic silencing of WNT signaling pathway genes in the pathogenesis of IBD-associated neoplasia...
  33. doi Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..the association between common, putative functional polymorphisms in DNFA5, HIF1A, NDRG1, PYGO1, SFRP2, SFRP4, WISP1 and WISP3 genes and CRC risk...
  34. ncbi Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
    C Leimeister
    Department of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Am Hubland, D 97074, Wuerzburg, Germany
    Mech Dev 75:29-42. 1998
    ..In a comparative analysis transcripts of the related sFRP1 and sFRP4 genes were frequently found in the same tissues as sFRP2 with their expression domains overlapping in some ..
  35. ncbi Global gene profiling in human endometrium during the window of implantation
    L C Kao
    Department of Gynecology and Obstetrics, Stanford University, Stanford, California 94305, USA
    Endocrinology 143:2119-38. 2002
    ..50-fold)], matrilysin, members of the G protein-coupled receptor signaling pathway, frizzled-related protein (FrpHE, a Wnt antagonist), transcription factors, TGF-beta signaling pathway members, immune modulators (major ..
  36. ncbi Embryonic myogenesis pathways in muscle regeneration
    Po Zhao
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Dev Dyn 229:380-92. 2004
    ..Moreover, antagonists of Wnt signaling, sFRP1, sFRP2, and sFRP4 (secreted frizzled-related proteins) were significantly up-regulated, suggesting active inhibition of the Wnt ..
  37. ncbi Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma
    Amie Y Lee
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Oncogene 23:6672-6. 2004
    ..Methylation-specific PCR (MSP) analysis showed that SFRP1, SFRP4, and SFRP5 gene promoters are frequently methylated in MM primary tissue (>80%)...
  38. ncbi Placental expression of secreted frizzled related protein-4 in the rat and the impact of glucocorticoid-induced fetal and placental growth restriction
    Damien P Hewitt
    School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia 6009, Australia
    Biol Reprod 75:75-81. 2006
    ..In this study, we compared the expression patterns of one of these secreted molecules, SFRP4, in the two morphologically and functionally distinct regions of the rat placenta during the last third of ..
  39. ncbi Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:1761-6. 2006
    ..Using methylation-specific PCR, the prevalence of methylation of SFRP1, SFRP2, SFRP4 and SFRP5 was 35, 32, 35 and 29%, respectively among 350 HNSCC cases...
  40. pmc Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas
    Ivan Martinez
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Room East 1240, 200 Lothrop Street, Pittsburgh, PA 15208, USA
    Eur J Cancer 43:415-32. 2007
    ..The upregulated genes included those involved in cell cycle regulation (CDKN2A), cell differentiation (SFRP4) and DNA repair (RAD51AP1), while the downregulated genes included those involved in proteolysis (PRSS3)...
  41. ncbi Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
    Jose Roman-Gomez
    Department of Hematology, Hospital Reina Sofia, Cordoba, Spain
    Blood 109:3462-9. 2007
    ..We found that expression of the Wnt inhibitors sFRP1, sFRP2, sFRP4, sFRP5, WIF1, Dkk3, and Hdpr1 was down-regulated due to abnormal promoter methylation in ALL cell lines and ..
  42. ncbi SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway
    Yu Lueng Shih
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Int J Cancer 121:1028-35. 2007
    ..To confirm and extend these findings, the methylation status of the other SFRP members, including SFRP2, SFRP4 and SFRP5, was examined by methylation-specific polymerase chain reaction (MS-PCR)...
  43. ncbi Wnt3a binds to several sFRPs in the nanomolar range
    Danuta Wawrzak
    Laboratory for Cell Genetics, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
    Biochem Biophys Res Commun 357:1119-23. 2007
    ..Here we show, using surface plasmon resonance and purified proteins, that sFRP1, sFRP2, sFRP4, and Frzb bind directly to Wnt3a with affinities in the nanomolar range...
  44. ncbi Gene expression profiling of oral submucous fibrosis using oligonucleotide microarray
    Yanjia Hu
    Department of Oral and Maxillofacial Surgery, Xiang Ya Hospital, Central South University, 410008 Changsha, People s Republic of China
    Oncol Rep 20:287-94. 2008
    ..Five EMT-related genes including SFRP4, THBS1, MMP2, ZO-1, and CK18 were validated with RT-PCR...
  45. ncbi Oncogenic osteomalacia, a rare paraneoplastic syndrome due to phosphate wasting--a case report and review of the literature
    M Woznowski
    Department of Nephrology, Heinrich Heine University, Moorenstrasse 5, Duesseldorf, Germany
    Clin Nephrol 70:431-8. 2008
    ..identified factors involved in the regulation of phosphate homeostasis such as the secreted frizzled related protein 4 (sFRP-4), the fibroblast growth factors 7 and 23 (FGF-7/-23), or the matrix extracellular ..
  46. ncbi [Phosphatonins: novel insights and clinical perspectives]
    G Mossetti
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi Federico II, Napoli
    G Ital Nefrol 26:171-80. 2009
    ..These factors--fibroblast growth factors (FGF) 23 and 7, secreted frizzled related protein 4 (sFRP-4), and matrix extracellular phosphoglycoprotein (MEPE)--primarily regulate tubular phosphate ..
  47. doi Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of beta-catenin protein
    Jongsung Lee
    Biospectrum Life Science Institute, 101 701 SK Ventium, 522 Dangjung Dong, Gunpo City, 435 833 Gyunggi Do, Republic of Korea
    Life Sci 86:416-23. 2010
    ..This study was conducted to elucidate the inhibitory mechanisms of isorhamnetin during adipogenic differentiation of human adipose tissue-derived stem cells (hAMSCs)...
  48. pmc Alternative splicing in bone following mechanical loading
    Sara M Mantila Roosa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Bone 48:543-51. 2011
    ..genes across the time course, and five alternatively spliced genes were validated with qPCR: Akap12, Fn1, Pcolce, Sfrp4, and Tpm1...
  49. pmc Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis
    Marta Christov
    Department of Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 152:2031-6. 2011
    ..In addition to Fgf23, secreted frizzled-related protein 4 (Sfrp4) has recently been implicated as an additional phosphate regulator in vivo and in vitro...
  50. pmc The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells
    Caroline E Ford
    Wnt Signalling and Metastasis Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 8:e54362. 2013
    ..Expression of secreted frizzled related protein 4 (SFRP4), an extracellular modulator of the Wnt signalling pathway, is progressively lost in more ..
  51. doi RNA/DNA co-analysis from human menstrual blood and vaginal secretion stains: results of a fourth and fifth collaborative EDNAP exercise
    C Haas
    Institute of Legal Medicine, University of Zurich, Switzerland Electronic address
    Forensic Sci Int Genet 8:203-12. 2014
    ..novel menstrual blood mRNA multiplexes were used: MMP triplex (MMP7, MMP10, MMP11) and MB triplex (MSX1, LEFTY2, SFRP4) in conjunction with a housekeeping gene triplex (B2M, UBC, UCE)...
  52. doi Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells
    Sudha Warrier
    Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, India
    Oncol Res 21:93-102. 2013
    ..We examined the effect of secreted frizzled-related protein 4 (sFRP4), a Wnt signaling antagonist, in chemosensitizing the glioma cell line U138MG and glioma stem cells (GSCs) ..
  53. doi Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus
    Shazia Anwer Bukhari
    Department of Applied Chemistry and Biochemistry, Government College University, Allama Iqbal Road, Faisalabad 38000, Pakistan
    Molecules 19:10129-36. 2014
    ..Secreted frizzled-related protein 4 (SFRP4) is found to cause five times more risk of diabetes when expressed above average levels...
  54. pmc Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene
    Kiyoshi Mori
    Department of Pathology, Division of Diagnostic Molecular Pathology, Kobe University Graduate School of Medicine, Kobe City, Japan Department of Pathology, National Hospital Organization, Osaka National Hospital, Hoenzaka, Chuo Ku, Osaka City, Japan
    PLoS ONE 9:e102797. 2014
    ....
  55. doi Genetic diseases of renal phosphate handling
    Carsten A Wagner
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Nephrol Dial Transplant 29:iv45-54. 2014
    ..syndromes of renal phosphate wasting, hypophosphatemia and osteomalacia (tumour-associated osteomalacia) can be due to the excessive synthesis or release of phosphaturic factors (FGF23, FGF-7, MEPE and sFRP4) from mesenchymal tumours.
  56. doi MicroRNA-152 modulates the canonical Wnt pathway activation by targeting DNA methyltransferase 1 in arthritic rat model
    Cheng Gui Miao
    School of Food and Drug, Anhui Key Laboratory of Poultry Epidemic Prevention and Surveillance, Anhui Science and Technology University, Bengbu 233100, China School of Pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei 230032, China
    Biochimie 106:149-56. 2014
    ..we identified that increased methyl-CpG-binding protein 2 (MeCP2) reduced the secreted frizzled-related protein 4 (SFRP4) expression in FLS in Arthritic rat model and the DNA methyltransferase (DNMT) inhibitor 5-Aza-2'-deoxycytidine (5-..
  57. doi PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma
    Tsuyoshi Saito
    Department of Human Pathology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Mutagenesis 30:297-301. 2015
    ..activation of the Wnt signalling pathway by epigenetic silencing of secreted frizzled-related protein 4 (SFRP4) is observed in this tumour...
  58. ncbi sFRP-4, a potential novel serum marker for chronic hepatitis B-related hepatocellular carcinoma
    Cheng Xu
    Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University Chongqing Key Laboratory for Research of Infectious Diseases, Chongqing 400038, China
    Hepatobiliary Pancreat Dis Int 14:164-70. 2015
    ..Here, we assessed the serum levels of secreted frizzled related protein 4 (sFRP-4) for diagnosing HCC in patients infected with chronic hepatitis B (CHB).
  59. doi Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice
    Jason Mastaitis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Endocrinology 156:4502-10. 2015
    Secreted frizzled-related protein 4 (SFRP4) is an extracellular regulator of the wingless-type mouse mammary tumor virus integration site family (WNT) pathway...
  60. pmc sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss
    Ryuma Haraguchi
    Department of Molecular Pathology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791 0295, Japan
    Sci Rep 6:25198. 2016
    b>sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts...
  61. doi Antagonizing canonical Wnt signaling pathway by recombinant human sFRP4 purified from E. coli and its implications in cancer therapy
    Archita Ghoshal
    Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 39, India
    Mol Cell Biochem 418:119-35. 2016
    ..We have purified and characterized bacterially expressed glutathione S-transferase-tagged SFRP4 from a novel clone generated from human cell origin...
  62. ncbi Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes
    Yury O Nunez Lopez
    Translational Research Institute for Metabolism and Diabetes, Florida Hospital, 301 East Princeton St, Orlando, FL 32804, USA
    Mol Biosyst 13:106-121. 2016
    ..Specifically, cytokines IL-6, IL-8, IL-10, IL-12, and SFRP4, as well as miRNAs miR-21, miR-24...
  63. pmc Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling
    Xiang Li
    Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 113:E8267-E8276. 2016
    ..promoter demethylation and transcriptional activation of the Wnt inhibitor secreted frizzled-related protein 4 (Sfrp4). Tet1/2/3-deficient embryos (embryonic day 8.0-8...
  64. ncbi Alterations in estrogen-associated proliferation markers in histologically-normal endometrium of obese women
    R A Lacour
    University of Texas M D Anderson Cancer Center, Houston, TX University of Texas School of Medicine, Houston, TX
    J Clin Oncol 26:16503. 2008
    ..Our group has previously described EIG121 as a relevant pro-proliferation biomarker and RALDH2 and SFRP4 as anti-proliferation biomarkers in the endometrium...
  65. pmc Sequencing and bioinformatics analysis of the differentially expressed genes in herniated discs with or without calcification
    Jia Shao
    Department of Orthopedics, Peking University Third Hospital, Beijing 100191, P R China
    Int J Mol Med 39:81-90. 2017
    ..the top 20 DEGs [sclerostin (SOST), WNT inhibitory factor 1 (WIF1) and secreted frizzled related protein 4 (SFRP4)] were related to the inhibition of the Wnt pathway...
  66. doi Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells
    A C Green
    St Vincent s Institute, Fitzroy, Victoria 3065, Australia Department of Medicine at St Vincent s Hospital, The University of Melbourne, Victoria 3065, Australia
    Exp Cell Res 350:284-297. 2017
    ..RAR agonist treatment resulted in significant upregulation of the Wnt antagonist, Sfrp4. This accompanied reduced nuclear and cytosolic β-catenin protein and reduced expression of the Wnt target gene ..
  67. pmc Whole Exome Sequencing in Psoriasis Patients Contributes to Studies of Acitretin Treatment Difference
    Xingchen Zhou
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
    Int J Mol Sci 18:. 2017
    ..in CRB2, rs11086065A>G in ANKLE1, rs3821414T>C in ARHGEF3, rs1802073 T>G in SFRP4) were found to be significantly associated with acitretin response in either co-dominant or dominant models ..
  68. ncbi Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells
    S Leah Etheridge
    Biomedical Tissue Research, Department of Biology, PO Box 373, University of York, Y010 5YW, UK
    Stem Cells 22:849-60. 2004
    ..protein-5 (LRP-5), kremen-1, dickkopf-1 (Dkk-1), secreted Frizzled-related peptide (sFRP)-2, sFRP3, sFRP4, Disheveled (Dvl), GSK-3beta, adenomatous polyposis coli (APC), beta-catenin,T-cell factor (TCF)-1, and TCF-4, ..
  69. pmc CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors
    Chi Ming Li
    Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 165:1943-53. 2004
    ..factors (MOX2, LBX1, SIM2), signaling molecules (TGFB2, FST, BMP2A), extracellular Wnt inhibitors (WIF1, SFRP4), and known beta-catenin/TCF targets (FST, CSPG2, CMYC)...
  70. doi Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair
    Carmen E Macsai
    Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Bone 50:1081-91. 2012
    ..development were identified across the time-course of bone bridge formation, including Wnt signalling (SFRP1, SFRP4, β-catenin, Csnk2a1, Tcf7, Lef1, Fzd1, Fzd2, Wisp1 and Cpz), BMP signalling (BMP-2, BMP-6, BMP-7, Chrd, Chrdl2 ..
  71. pmc Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed
    Yi Hsiang Hsu
    Hebrew SeniorLife Institute for Aging Research, 1200 Centre Street, Boston, Massachusetts 02131, USA
    J Clin Endocrinol Metab 97:E1958-77. 2012
    ..In addition, the identified genetic determinants may be used to enhance current risk factor profiles...
  72. doi Role of WNT/β-catenin signaling in rejuvenating myogenic differentiation of aged mesenchymal stem cells from cardiac patients
    Keith R Brunt
    Division of Cardiovascular Surgery and Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
    Am J Pathol 181:2067-78. 2012
    ..genes in the WNT/β-catenin signaling network and found that transcript levels of CTNNB1, LEF1, FZD8, WNT3A, and SFRP4 were negatively correlated with age, whereas FOSL1, LRP6, and FZD6 were positively correlated with age...
  73. pmc Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts
    Rongrong Zhang
    Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA 70112, USA
    Bone 52:145-56. 2013
    ..contrast, transcription of BMP2 in osteogenic cells was decreased by either blocking the Wnt pathway with DKK1 and sFRP4, or inhibiting β-catenin/TCF4 activity with FWD1/β-TrCP, ICAT, or ΔTCF4...
  74. doi Methylation of Wnt antagonist genes: a useful prognostic marker for myelodysplastic syndrome
    Hong Wang
    Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, No 188 Shi Zi Street, Suzhou, China
    Ann Hematol 92:199-209. 2013
    ..6 % for sFRP2, 43.1 % for sFRP4, 50.7 % for sFRP5, 44.4 % for DKK-1, and 69.4 % for DKK-3...
  75. doi Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
    Taman Mahdi
    Lund University Diabetes Centre, Lund University, 20502 Malmo, Sweden
    Cell Metab 16:625-33. 2012
    ..One of the module genes that was highly overexpressed in islets from T2D patients is SFRP4, which encodes secreted frizzled-related protein 4...
  76. doi MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats
    Cheng Gui Miao
    School of Pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei 230032, China
    Cell Signal 25:598-608. 2013
    ..There were increased MeCP2 and decreased secreted frizzled-related protein 4 (SFRP4) in synovium as well as the FLS isolated from the synovium of RA rats...
  77. pmc Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia
    Zhan Zhang
    Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, No 7 Front Kangfu Street, Zhengzhou, Henan, China
    Reprod Sci 20:981-9. 2013
    ..However, published data regarding the association between Wnt pathway and PE in human pregnancy is rare...
  78. pmc Effect of zoledronate on the responses of osteocytes to acute parathyroid hormone
    Shinichiro Kuroshima
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Calcif Tissue Int 92:576-85. 2013
    ..We found that ZA treatment altered bone responses to PTH. Expression of Sfrp4, a Wnt antagonist, was significantly increased in ZA-affected osteocytes...
  79. doi Wnt/β-catenin signaling and adipogenic genes are associated with intramuscular fat content in the longissimus dorsi muscle of Korean cattle
    J Y Jeong
    Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, 564 Omockchun dong, Suwon, 441 706, Republic of Korea
    Anim Genet 44:627-35. 2013
    ..and CTNNB1 genes, whereas it increased the expression of the Wnt antagonist secreted frizzled-related proteins 4 (SFRP4, P < 0.001) and the adipogenic CCAAT/enhancer binding protein (C/EPB), alpha (CEBPA, P < 0...
  80. doi Wnt-related genes and large-joint osteoarthritis: association study and replication
    Carmen García-Ibarbia
    Department of Internal Medicine, Hospital U M Valdecilla, IFIMAV, University of Cantabria, Av Valdecilla sn, 39008, Santander, Spain
    Rheumatol Int 33:2875-80. 2013
    ..SNPs were located in WNT1, WNT10A, WNT16, DVL2, FZD5, BCL9, SFRP1, TCF7L1 and SFRP4 genes...
  81. ncbi DDC-4, an apoptosis-associated gene, is a secreted frizzled relative
    V Wolf
    Department of Clinical Research, University of Berne, Switzerland
    FEBS Lett 417:385-9. 1997
    ..e. the ligand-binding domain, of the fizzled gene family originally defined as tissue polarity genes in Drosophila. The homology of Y81 clone 40 is most extensive with the newly described secreted frizzled relatives, the frzb subfamily...
  82. ncbi Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway
    A R Rhoads
    Department of Biochemistry and Molecular Biology, Howard University, Washington, DC 20059, USA
    Mol Psychiatry 4:437-42. 1999
    ..axin, alpha-catenin, the Armadillo repeat-containing genes (delta-catenin and ARVCF), and a frizzled-like protein (frpHE) using the Stanford Human Genome Center (SHGC) G3 panel...
  83. ncbi Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression
    H Schumann
    Molecular Biology Group, Medical Faculty of Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Cardiovasc Res 45:720-8. 2000
    ..On the basis of these considerations, the present investigation compares myocardial mRNA expression of sFRPs and the level of soluble beta-catenin in tissue samples from nonfailing and failing hearts...
  84. ncbi Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell
    James Walsh
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    APMIS 111:197-210; discussion 210-1. 2003
    ..FZD4, FZD5, FZD6), encoding receptors forWnt proteins, the Frizzled Related Protein family (SFRPI, SFRP2, FRZB, SFRP4), encoding solubleWnt antagonists and also ligands and receptors of the Notch pathway (Dlkl, Jaggedl; Notchl, ..
  85. pmc Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
    Theresa Berndt
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 112:785-94. 2003
    ..Thus, sFRP-4 displays phosphatonin-like properties, because it is a circulating protein that promotes phosphaturia and hypophosphatemia and blunts compensatory increases in 1alpha, 25-dihydroxyvitamin D...
  86. ncbi The phosphatonin pathway: new insights in phosphate homeostasis
    Susan C Schiavi
    Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    Kidney Int 65:1-14. 2004
    ..Future experiments should clarify their physiologic and pathologic roles in phosphate metabolism...
  87. ncbi Determination of genes involved in the early process of embryonic implantation in rhesus monkey (Macaca mulatta) by suppression subtractive hybridization
    Xiao yang Sun
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Biol Reprod 70:1365-73. 2004
    ..To our knowledge, this is the first report to determine genes involved in the early implantation stage in the rhesus monkey with high throughput technology...
  88. pmc Microarray profiling of progesterone-regulated endometrial genes during the rhesus monkey secretory phase
    Christopher I Ace
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA, USA
    Reprod Biol Endocrinol 2:54. 2004
    ..Endometrial receptivity is a complex process that is spatially and temporally restricted and the identity of genes that regulate receptivity has been pursued by a number of investigators...
  89. pmc The wrickkened pathways of FGF23, MEPE and PHEX
    Peter S N Rowe
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, Mail Code 7894, 7703 Floyd Curl Drive, Room 3 579U, San Antonio, TX 78229 3900, USA
    Crit Rev Oral Biol Med 15:264-81. 2004
    ....
  90. ncbi Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 65:743-8. 2005
    ..Here, we report that silencing of SFRP4 is correlated with promoter hypermethylation in beta-catenin-deficient mesothelioma cell lines...
  91. ncbi Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein
    Yasuyoshi Naishiro
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:3141-53. 2005
    ..Those genes included known negative regulators of the Wnt signaling pathway, Sfrp4 and Axin2; extracellular matrix and related molecule, Hxb and Crtl1; cell adhesion and cytoskeletal proteins, ..
  92. ncbi Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling
    John I Risinger
    Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 65:5031-7. 2005
    ..In particular, we found evidence that two members of the secreted frizzled related protein family (SFRP1 and SFRP4) were more frequently down-regulated in MSI cancers as compared with MSS cancers...
  93. ncbi Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function
    Minnie Hsieh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 73:1135-46. 2005
    ..Expression of luteal cell-specific mRNAs (Lhcgr, Prlr, Cyp11a1 and Sfrp4) is reduced, luteal cell morphology is altered, and markers of angiogenesis and vascular formation (Efnb1, Efnb2, ..
  94. ncbi Phosphate diabetes, tubular phosphate reabsorption and phosphatonins
    Michel Laroche
    Rheumatology Department, Rangueil Teaching Hospital, Toulouse, France
    Joint Bone Spine 72:376-81. 2005
    ..may exist, such as matrix extracellular phosphoglycoprotein (MEPE) and secreted frizzled-related protein 4 (SFRP4), whose role remains to be defined...
  95. ncbi CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia
    Te Hui Liu
    Department of Molecular Virology, Immunology, and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Res 66:653-8. 2006
    ..Secreted frizzled-related protein 4 (SFRP4), a negative regulator of the Wnt signaling pathway, was found to be frequently methylated in CLL samples...
  96. ncbi WNT antagonist, DKK2, is a Notch signaling target in intestinal stem cells: augmentation of a negative regulation system for canonical WNT signaling pathway by the Notch-DKK2 signaling loop in primates
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:197-201. 2007
    ..region of genes encoding secreted WNT signaling inhibitors, including DKK1, DKK2, DKK3, DKK4, SFRP1, SFRP2, SFRP3, SFRP4, SFRP5 and WIF1...
  97. pmc Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption
    Theresa Berndt
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 104:11085-90. 2007
    ..Our experiments demonstrate the presence of a previously unrecognized phosphate gut-renal axis that rapidly modulates renal phosphate excretion after the intestinal administration of phosphate...
  98. ncbi Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leukemia 21:2527-36. 2007
    ..We studied the activity of Wnt signaling and the methylation status of WIF1, DKK3, APC, SFRP1, SFRP2, SFRP4 and SFRP5 by methylation-specific PCR in myeloma cell lines and primary myeloma samples...
  99. pmc Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
    Heinz G Linhart
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 21:3110-22. 2007
    ..expression of Igf2 as well as methylation and transcriptional silencing of the tumor suppressor genes Sfrp2, Sfrp4, and Sfrp5...
  100. ncbi DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Lab Invest 88:161-70. 2008
    ..We identified 17 novel methylation markers in GC, including SFRP4, SEZ6L, TWIST1, BCL2, KL, TERT, SCGB3A1, IGF2, GRIN2B, SFRP5, DLEC1, HOXA1, CYP1B1, SMAD9, MT1G, NR3C1, and HOXA10...
  101. doi Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts
    Sun Wook Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 367:399-405. 2008
    ..In conclusion, we found that different repertoires of sFRPs exert differential effects on osteoblastic differentiation of mouse mesenchymal cells and cellular apoptosis of mouse osteoblasts in vitro...

Research Grants8

  1. Dolores M Shoback; Fiscal Year: 2015
    ..the inhibitory G protein (Gi) is itself inhibited by overexpression of pertussis toxin, and the wnt inhibitor sFRP4 is deleted in a bone cell specific fashion will be examined for their impact on fracture healing per se, and on ..
  2. PHASE II CLINICAL TRAIL - AN EXPLORATORY STUDY TO IDENTI
    Karen Lu; Fiscal Year: 2000
    ..Paraquine/Autocrine Pathway #1 - Wnt 5a, Wnt 2, Friz 5, Friz 7, sFRP1, sFRP4, APC, beta-catenin C. Paraquine/Autocrine Pathway #2 - IGF-1, IGF-2, IGFBP-3, IGFBP-5, IGFBPR-1 D...
  3. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 2003
    ..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..
  4. THE STRUCTURE OF CALBINDIN-D28K
    Rajiv Kumar; Fiscal Year: 2004
    ..These findings will potentially be of significance in the understanding of neurodegenerative disorders, cerebellar function and long-term hippocampal potentiation. ..
  5. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..Our findings will have important implications with respect to Pi homeostasis, bone mineralization in mammals and humans, and the regulation of ion transport through Wnt signaling in the kidney. ..
  6. EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTOR
    Rajiv Kumar; Fiscal Year: 2007
    ..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..
  7. Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for Obesity
    Rajiv Kumar; Fiscal Year: 2008
    ..Finally, we will study why these complications occur and we will develop ways in which to prevent kidney stones and loss of kidney function after gastric bypass surgery. [unreadable] [unreadable] [unreadable]..
  8. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
    ..The interaction between the FGF 7 and other PTNs will be clarified. Such information will significantly enhance our knowledge of mineralization processes and Pi homeostasis. ..