SF-1

Summary

Gene Symbol: SF-1
Description: nuclear receptor subfamily 5 group A member 1
Alias: AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, steroidogenic factor 1, STF-1, adrenal 4 binding protein, fushi tarazu factor homolog 1, nuclear receptor AdBP4, steroid hormone receptor Ad4BP, steroidogenic factor 1 nuclear receptor, steroidogenic factor-1
Species: human

Top Publications

  1. pmc Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region
    M A Daggett
    Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 62:670-9. 2000
  2. ncbi A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4
    Jacques J Tremblay
    Ontogeny Reproduction Research Unit, CHUL Research Centre and Centre de Recherche en Biologie de la Reproduction, Department of Obstetrics and Gynecology, Universite Laval, 2705 Laurier Boulevard, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 278:42637-42. 2003
  3. ncbi Amplification of the steroidogenic factor 1 gene in childhood adrenocortical tumors
    Bonald C Figueiredo
    Department of Pediatrics, Center for Molecular Genetics and Cancer Research In Children, Federal University of Parana, Curitiba PR 80 030 110, Brazil
    J Clin Endocrinol Metab 90:615-9. 2005
  4. ncbi Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 355:1012-8. 2007
  5. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
  6. ncbi Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones
    Ya Hui Huang
    Department of Biochemistry, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Endocrinology 147:2481-9. 2006
  7. ncbi Structural characterization of human Ad4bp (SF-1) gene
    K Oba
    Third Department of Internal Medicine, Graduate School of Medical Science, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 226:261-7. 1996
  8. ncbi Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription
    Marion B Sewer
    Department of Biochemistry and Center in Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Endocrinology 143:1280-90. 2002
  9. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
  10. ncbi The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
    S L Asa
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:2165-70. 1996

Research Grants

  1. OVARIAN TUMOR NECROSIS FACTOR
    Paul Terranova; Fiscal Year: 2004
  2. RAYMOND DANIEL BLIND; Fiscal Year: 2015
  3. Molecular Mechanisms of Gonadotrope Differentiation
    Pamela L Mellon; Fiscal Year: 2010
  4. ORPHAN NUCLEAR RECEPTORS IN DEVELOPMENT AND DISEASE
    Gary Hammer; Fiscal Year: 2000
  5. MECHANISMS LEADING TO ADRENAL ZONATION
    William E Rainey; Fiscal Year: 2012
  6. Gary D Hammer; Fiscal Year: 2014
  7. Gary D Hammer; Fiscal Year: 2016
  8. Marion B Sewer; Fiscal Year: 2014
  9. STEPHANIE CORREA; Fiscal Year: 2015
  10. Bradford B Lowell; Fiscal Year: 2014

Detail Information

Publications238 found, 100 shown here

  1. pmc Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region
    M A Daggett
    Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 62:670-9. 2000
    b>Steroidogenic factor 1 (SF-1), also known as adrenal 4-binding protein, is a member of the nuclear hormone receptor family that regulates transcription of genes encoding hormones and steroidogenic enzymes important to the function of the ..
  2. ncbi A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4
    Jacques J Tremblay
    Ontogeny Reproduction Research Unit, CHUL Research Centre and Centre de Recherche en Biologie de la Reproduction, Department of Obstetrics and Gynecology, Universite Laval, 2705 Laurier Boulevard, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 278:42637-42. 2003
    b>Steroidogenic factor 1 (SF-1) is a transcription factor belonging to the nuclear receptor superfamily. SF-1 regulates the expression of many genes involved in reproduction, steroidogenesis, and sexual differentiation...
  3. ncbi Amplification of the steroidogenic factor 1 gene in childhood adrenocortical tumors
    Bonald C Figueiredo
    Department of Pediatrics, Center for Molecular Genetics and Cancer Research In Children, Federal University of Parana, Curitiba PR 80 030 110, Brazil
    J Clin Endocrinol Metab 90:615-9. 2005
    ..To follow up on these results, we examined whether the steroidogenic factor 1 (SF-1) gene, which is located in this chromosomal region and plays an important role in the development ..
  4. ncbi Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 355:1012-8. 2007
    ..We recently reported that atrazine induces human aromatase gene expression via promoter II (ArPII) in a steroidogenic factor 1 (SF-1)-dependent manner...
  5. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  6. ncbi Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones
    Ya Hui Huang
    Department of Biochemistry, Chang Gung University, Taoyuan, Taiwan, Republic of China
    Endocrinology 147:2481-9. 2006
    ..SULT2A1 has been reported to be regulated by the two transcription factors, steroidogenic factor 1 (SF1) and GATA, in the human adrenal gland. T(3) induced a 2.5- to 3...
  7. ncbi Structural characterization of human Ad4bp (SF-1) gene
    K Oba
    Third Department of Internal Medicine, Graduate School of Medical Science, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 226:261-7. 1996
    Ad4BP (or steroidogenic factor 1, SF-1) has been implicated to be an essential transcriptional factor for steroidogenesis as well as for the development of the reproductive axis. We elucidated the structure of the human Ad4BP gene...
  8. ncbi Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription
    Marion B Sewer
    Department of Biochemistry and Center in Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Endocrinology 143:1280-90. 2002
    ..Our studies lend support to the idea that the balance between transcriptional activation and repression is essential in the control of adrenocortical steroid hormone biosynthesis...
  9. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
    ..X chromosome, gene 1 (NR0B1)] is an orphan nuclear receptor acting as a suppressor of Ad4 binding protein/steroidogenic factor 1 [Ad4BP/SF-1 (NR5A1)] and as an anti-Sry factor in the process of gonadal sex differentiation...
  10. ncbi The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
    S L Asa
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:2165-70. 1996
    ..We conclude that SF-1 expression correlates with the expression of gonadotropins. These findings implicate SF-1 as a cell-specific transcription factor that may regulate gonadotroph differentiation in the pituitary...
  11. ncbi Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function
    K i Morohashi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka, Japan
    FASEB J 10:1569-77. 1996
    b>Ad4BP/SF-1 was identified as the steroidogenic tissue-specific transcription factor regulating the expression of the steroidogenic cytochrome P450 genes...
  12. ncbi Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression
    M W Nachtigal
    Department of Physiology, University of California at San Francisco, 94143 0444, USA
    Cell 93:445-54. 1998
    Products of steroidogenic factor 1 (SF-1) and Wilms' tumor 1 (WT1) genes are essential for mammalian gonadogenesis prior to sexual differentiation...
  13. pmc Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain
    J J Tremblay
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    EMBO J 18:3431-41. 1999
    ..It was shown to cooperate with cell-restricted factors, such as Pit1, NeuroD1/PanI and steroidogenic factor 1 (SF-1), to establish a combinatorial code conferring lineage- and promoter-specific gene transcription in ..
  14. ncbi Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1
    J J Tremblay
    Unité de Recherche en Ontogénie et Reproduction Centre Hospitalier Universitaire de Québec, Pavillon Centre Hospitalier de l Université Laval, Ste Foy, Quebec, Canada
    Mol Endocrinol 13:1388-401. 1999
    ....
  15. pmc Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA
    E Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Illkirch Strasbourg, France
    Mol Cell Biol 20:4910-21. 2000
    ..Mutations in DAX-1 found in AHC-HHG patients significantly impair RNA binding. These findings reveal that DAX-1 plays multiple regulatory roles at the transcriptional and posttranscriptional levels...
  16. ncbi Sp1 and SF-1 interact and cooperate in the regulation of human steroidogenic acute regulatory protein gene expression
    T Sugawara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Endocrinology 141:2895-903. 2000
    ..b>Steroidogenic factor 1 (SF-1) controls basal and cAMP-stimulated transcription of the StAR gene. The 1...
  17. ncbi Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1
    M H Bassett
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    J Mol Endocrinol 28:125-35. 2002
    ..Taken together, these data suggest that SF-1 and the Ad4 element are not major regulators of adrenal hCYP11B2 gene expression. Thus far, hCYP11B2 is the first steroid hydroxylase gene which is not positively regulated by SF-1...
  18. ncbi Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle
    Yoko Sato
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 88:3415-20. 2003
    ..Recent studies have demonstrated that DAX-1 and COUP-TFII negatively regulate adrenal 4 binding protein (Ad4BP)/steroidogenic factor-1 (SF-1)-dependent transcription of steroidogenic enzymes in experimental ..
  19. pmc T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors
    Jennifer A Kennell
    Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
    Mol Cell Biol 23:5366-75. 2003
    ..the alpha-inhibin promoter through functional and physical interactions with the orphan nuclear receptor steroidogenic factor 1 (SF-1)...
  20. ncbi Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1
    Yun Yong Park
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 18:1082-95. 2004
    ..of 25 extra amino acids in H6-H7 had no significant difference in the interaction and repression of steroidogenic factor 1 transactivation...
  21. ncbi Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing
    Anwar Hossain
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Mol Endocrinol 18:1428-37. 2004
    ..We also found that DAX-1alpha can bind to steroidogenic factor 1 and to DNA but is unable to repress steroidogenic factor 1-mediated transcriptional activation of the ..
  22. ncbi Transcriptional regulation of human Oct4 by steroidogenic factor-1
    Heung Mo Yang
    Chabiotech Co Ltd, Seoul, South Korea
    J Cell Biochem 101:1198-209. 2007
    ..Thus, our data indicate that SF-1 plays a crucial role in the regulation of hOct4 transcription through direct binding to the 1st SF-1 in CR1 of the hOct4 proximal promoter...
  23. pmc Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Environ Health Perspect 115:720-7. 2007
    ..Atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP...
  24. ncbi Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells
    Tomoko Tanaka
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Endocrinol 39:343-50. 2007
    Steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential nuclear receptor for steroidogenesis as well as for adrenal and gonadal gland development...
  25. doi Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies
    Noriko Sakai
    Department of Stem Cell Based Drug Discovery, Research Center Kobe, Bayer Yakuhin Ltd, Kobe, Hyogo 650 0047, Japan
    J Endocrinol 198:489-97. 2008
    Nuclear receptor subfamily 5, group A, member 1 (NR5A1 previously known as SF-1/AD4BP) is a transcription factor involved in the development of adrenal/gonadal tissues and steroidogenic lineage cell differentiation in adult somatic stem ..
  26. pmc Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis
    Erkut Attar
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:623-31. 2009
    ..Prostaglandin E2 (PGE2) induces aromatase expression via the transcriptional factor steroidogenic factor-1 (SF1) in endometriosis, which is opposed by chicken-ovalbumin upstream-transcription factor (COUP-TF) and Wilms' tumor-1 ..
  27. pmc Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells
    Stefania Catalano
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Biol Chem 285:5581-93. 2010
    ..mobility shift, and chromatin immunoprecipitation analysis reveal that FXR is able to compete with steroidogenic factor 1 in binding to a common sequence present in the aromatase promoter region interfering negatively with its ..
  28. doi FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells
    Mira Park
    Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463 836, Korea
    Mol Endocrinol 24:1024-36. 2010
    ..Therefore, this study identifies a novel regulatory role for FOXL2 on a key steroidogenic enzyme and provides a possible mechanism by which mutations in FOXL2 disrupt normal ovarian follicle development...
  29. pmc Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    Y Sadovsky
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10939-43. 1995
    The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro...
  30. ncbi Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33
    M Taketo
    Banyu Tsukuba Research Institute Merck, Japan
    Genomics 25:565-7. 1995
    ..We have mapped the mouse gene Ftzf1 to the proximal quarter of Chr 2 by a linkage analysis using interspecific backcross mice, and its human homolog ..
  31. ncbi Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade
    W H Shen
    Department of Obstetrics, Gynocology, and Reproductive Sciences, University of California, San Francisco 94143 0556
    Cell 77:651-61. 1994
    ..In primary Sertoli cells, the orphan nuclear receptor, steroidogenic factor 1 (SF-1), regulates the MIS gene by binding to a conserved upstream regulatory element...
  32. ncbi Steroidogenic factor 1: a key determinant of endocrine development and function
    K L Parker
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocr Rev 18:361-77. 1997
  33. pmc Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene
    P de Santa Barbara
    Centre de Recherche de Biochime Macromoléculaire, CNRS UPR1142, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 18:6653-65. 1998
    ..A DNA-binding element for the steroidogenic factor 1 (SF-1), a member of the orphan nuclear receptor family, located in the AMH proximal promoter has recently ..
  34. ncbi Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress
    G D Hammer
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Mol Cell 3:521-6. 1999
    b>Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that serves as an essential regulator of many hormone-induced genes in the vertebrate endocrine system...
  35. ncbi A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans
    J C Achermann
    Nat Genet 22:125-6. 1999
  36. ncbi Synergistic activation of the inhibin alpha-promoter by steroidogenic factor-1 and cyclic adenosine 3',5'-monophosphate
    M Ito
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Endocrinol 14:66-81. 2000
    ..We propose a model in which direct interactions of SF-1, CREB, and associated coactivators like CBP induce strongly cooperative transactivation by pathways that individually have relatively weak effects on transcription...
  37. pmc Apparently normal ovarian differentiation in a prepubertal girl with transcriptionally inactive steroidogenic factor 1 (NR5A1/SF-1) and adrenocortical insufficiency
    A Biason-Lauber
    Department of Endocrinology and Diabetology, University Children s Hospital, Zurich, Switzerland
    Am J Hum Genet 67:1563-8. 2000
    b>Steroidogenic factor 1 (NR5A1/SF-1) plays an essential role in the development of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes, controlling expression of their many important genes...
  38. ncbi Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage
    R Kimura
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 278:63-71. 2000
    It has been demonstrated that the mammalian Ad4BP/SF-1 (NR5A1) gene is regulated precisely in sex, tissue, and developmental stage specific manners...
  39. ncbi Transcriptional regulators of steroidogenesis, DAX-1 and SF-1, are expressed in human skin
    M V Patel
    Center for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    J Invest Dermatol 117:1559-65. 2001
    ..Further studies are needed to determine the functional roles of DAX-1 and SF-1 in human skin...
  40. ncbi Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner
    John C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 87:1829-33. 2002
    ..In addition, these patients reveal the exquisite sensitivity of SF-1-dependent developmental pathways to gene dosage and function in humans...
  41. pmc Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene
    Suzanne B R Jacobs
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    Mol Endocrinol 17:1470-83. 2003
    ..This study is the first to demonstrate the presence of basal FSH beta protein in L beta T2 cells and to identify specific elements within the FSH beta promoter that contribute to basal and cell-specific expression of the gene...
  42. ncbi Functional characterization of a new human Ad4BP/SF-1 variation, G146A
    Fan WuQiang
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, 812 8582, Fukuoka, Japan
    Biochem Biophys Res Commun 311:987-94. 2003
    b>Ad4BP/SF-1 plays key roles at all levels of the hypothalamic-pituitary-steroidogenic organ axis and its functional disruption causes endocrine disorders of these organs...
  43. ncbi Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9
    Tomoko Komatsu
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Mol Endocrinol 18:2451-62. 2004
    An orphan nuclear receptor, Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1), is essential for the development and function of steroidogenic tissues...
  44. ncbi Gonadal dysgenesis without adrenal insufficiency in a 46, XY patient heterozygous for the nonsense C16X mutation: a case of SF1 haploinsufficiency
    Delphine Mallet
    Laboratoire de biochimie endocrinienne et moléculaire, Hopital Debrousse, and EA3739, Universite Claude Bernard, Lyon, France
    J Clin Endocrinol Metab 89:4829-32. 2004
    Targeted disruption of the orphan nuclear receptor SF1 results in the absence of adrenals and gonads, establishing that this transcription factor is implicated in gonadal determination and adrenal development...
  45. ncbi Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
    Irina N Krylova
    Department of Physiology, University of California, San Francisco, California 94143, USA
    Cell 120:343-55. 2005
    Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial aspects of development, endocrine homeostasis, and metabolism...
  46. pmc Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience
    Lin Lin
    UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 91:3048-54. 2006
    ..The nuclear receptors DAX1 (NR0B1) and steroidogenic factor-1 (SF1/Ad4BP, NR5A1) play an important role in adrenal development and function, and mutations in these transcription factors ..
  47. ncbi Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
    Aarti N Urs
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, Georgia 30332 0230, USA
    Endocrinology 147:5249-58. 2006
    Steroidogenic factor (SF1, Ad4BP, NR5A1) is a nuclear receptor that is essential for steroid hormone biosynthesis and endocrine development. Recent crystallographic studies have found that phospholipids are ligands for SF1...
  48. ncbi Heterozygous mutation of steroidogenic factor-1 in 46,XY subjects may mimic partial androgen insensitivity syndrome
    Regis Coutant
    Department of Pediatric Endocrinology, University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 92:2868-73. 2007
    ..In humans, mutations in steroidogenic factor-1 (SF-1), one of the critical factors involved in testis development, have been reported to cause gonadal dysgenesis with or without adrenal failure in 46,XY individuals...
  49. ncbi Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:3261-7. 2007
    ....
  50. ncbi Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer
    Mabrouka Doghman
    Institut de Pharmacologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique Unité Mixte de Recherche 6097, France
    Mol Endocrinol 21:2968-87. 2007
    Steroidogenic factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription factor, has a pivotal role in adrenal and gonadal development in humans and mice...
  51. pmc Mutational analysis of steroidogenic factor 1 (NR5a1) in 24 boys with bilateral anorchia: a French collaborative study
    Pascal Philibert
    Service d Hormonologie, Hopital Lapeyronie, CHU Montpellier, 34295 Montpellier Cedex 5, France
    Hum Reprod 22:3255-61. 2007
    BACKGROUND Steroidogenic factor 1 (SF1/AdBP4/FTZF1, NR5A1) is a nuclear receptor transcription factor that plays a key role in regulating adrenal and gonadal development, steroidogenesis and reproduction...
  52. pmc Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis
    Hiroki Utsunomiya
    Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Endocrinol 22:904-14. 2008
    ..Taken together, the elevated levels of USF2 in endometriosis account for, in part, the aberrant expression of SF-1 and its target gene StAR and aromatase...
  53. doi Deoxyribonucleic acid methylation controls cell type-specific expression of steroidogenic factor 1
    Erling A Hoivik
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Endocrinology 149:5599-609. 2008
    b>Steroidogenic factor 1 (SF1) is expressed in a time- and cell-specific manner in the endocrine system...
  54. pmc CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease
    Bruno Ferraz-de-Souza
    Developmental Endocrinology Research Group, University College London Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 94:678-83. 2009
    ..Disorders of adrenal development result in significant morbidity and mortality. However, the molecular basis of human adrenal development, and many forms of disease, is still poorly understood...
  55. pmc Mutations in NR5A1 associated with ovarian insufficiency
    Diana Lourenco
    Human Developmental Genetics, Institut Pasteur, Paris, France
    N Engl J Med 360:1200-10. 2009
    ..A nuclear receptor, NR5A1 (also called steroidogenic factor 1), is a key transcriptional regulator of genes involved in the hypothalamic-pituitary-steroidogenic axis...
  56. pmc The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency
    Birgit Kohler
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 161:237-42. 2009
    Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found. Steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) is a key regulator of human sex development and an increasing number of SF-1 (NR5A1) mutations ..
  57. pmc Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation
    Benjamin C Lin
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, USA
    Cancer Res 69:5415-23. 2009
    ....
  58. doi Human steroidogenic factor-1 (hSF-1) regulates progesterone biosynthesis and growth of ovarian surface epithelial cancer cells
    M S Ramayya
    Section of Pediatric Endocrinology, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Steroid Biochem Mol Biol 119:14-25. 2010
    ..These findings are consistent with the hypothesis, that down-regulation of hSF-1 contributes to progression of ovarian epithelial cancers...
  59. doi Steroidogenic factor 1 overexpression and gene amplification are more frequent in adrenocortical tumors from children than from adults
    Madson Q Almeida
    Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular Laboratório de Investigação Médica 42, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Eneas de Carvalho Aguiar, 155, 20 andar Bloco 6, 05403 900 Sao Paulo, SP, Brasil
    J Clin Endocrinol Metab 95:1458-62. 2010
    b>Steroidogenic factor 1 (SF-1) is a key determinant of endocrine development and function of adrenal cortex. SF-1 overexpression and gene amplification were previously demonstrated in a small group of pediatric adrenocortical tumors.
  60. pmc Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration
    Pascal Philibert
    Service d Hormonologie, Hopital Lapeyronie, CHU Montpellier, and Université Montpellier 1, France
    Reprod Biol Endocrinol 8:28. 2010
    ..Among the genetic causes of low-testosterone primary amenorrhea due to 46,XY DSD, SRY gene is reported to be frequently involved, but other genes, such as SF1 and WT1, have never been studied for their prevalence.
  61. doi High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors
    Silviu Sbiera
    Department of Internal Medicine I, University Hospital of Wuerzburg, Wurzburg, Germany
    J Clin Endocrinol Metab 95:E161-71. 2010
    ....
  62. pmc Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1
    Anu Bashamboo
    Human Developmental Genetics, Institut Pasteur, 75724 Paris, France
    Am J Hum Genet 87:505-12. 2010
    ..A nuclear receptor, NR5A1 (also called steroidogenic factor 1), is a key transcriptional regulator of genes involved in the hypothalamic-pituitary-steroidogenic axis, ..
  63. pmc Steroidogenic factor-1 (SF-1, NR5A1) and human disease
    Bruno Ferraz-de-Souza
    Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    Mol Cell Endocrinol 336:198-205. 2011
    Steroidogenic factor-1 (SF-1, Ad4BP, encoded by NR5A1) is a key regulator of adrenal and reproductive development and function...
  64. doi Partial deletion of the NR5A1 (SF1) gene detected by synthetic probe MLPA in a patient with XY gonadal disorder of sex development
    M Barbaro
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Michela Barbaro ki se
    Sex Dev 5:181-7. 2011
    b>Steroidogenic factor 1 (SF1, officially NR5A1) is a nuclear receptor involved in adrenal and gonadal development...
  65. pmc Mutation analysis of NR5A1 encoding steroidogenic factor 1 in 77 patients with 46, XY disorders of sex development (DSD) including hypospadias
    Slimane Allali
    Universite Paris Descartes, Faculté de médecine and AP HP, Hopital Bicetre, Unité d endocrinologie, Pédiatrique, Le Kremlin Bicetre, France
    PLoS ONE 6:e24117. 2011
    ..Mutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias...
  66. ncbi Multifunctional role of steroidogenic factor 1 and disorders of sex development
    Maricilda Palandi de Mello
    Centro de Biologia Molecular e Engenharia Genetica, Universidade Estadual de Campinas, SP, Brazil
    Arq Bras Endocrinol Metabol 55:607-12. 2011
    ..One of the major proteins in mammalian gonadal differentiation is the steroidogenic nuclear receptor factor 1 (SF1)...
  67. pmc Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations
    Sally Tantawy
    Department of Pediatric Endocrinology, University Children s Hospital, Charite, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 167:125-30. 2012
    b>Steroidogenic factor 1 (SF-1, NR5A1) is a key transcriptional regulator of many genes involved in the hypothalamic-pituitary-gonadal axis and mutations in NR5A1 can result in 46,XY disorders of sex development (DSD)...
  68. doi Ten novel mutations in the NR5A1 gene cause disordered sex development in 46,XY and ovarian insufficiency in 46,XX individuals
    N Camats
    Pediatric Endocrinology Research Unit, Hospital Vall d Hebron, Passeig Vall d Hebron 119, Barcelona 08035, Spain
    J Clin Endocrinol Metab 97:E1294-306. 2012
    ..NR5A1 mutations have been detected in 46,XY individuals with disorders of sexual development (DSD) but apparently normal adrenal function and in 46,XX women with normal sexual development yet primary ovarian insufficiency (POI)...
  69. ncbi Preserved fertility in a patient with a 46,XY disorder of sex development due to a new heterozygous mutation in the NR5A1/SF-1 gene: evidence of 46,XY and 46,XX gonadal dysgenesis phenotype variability in multiple members of an affected kindred
    Marta Ciaccio
    Endocrinology Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res Paediatr 78:119-26. 2012
    In humans, steroidogenic factor 1 (NR5A1/SF-1) mutations have been reported to cause gonadal dysgenesis, with or without adrenal failure, in both 46,XY and 46,XX individuals...
  70. doi NR5A1 (SF-1) gene variants in a group of 26 young women with XX primary ovarian insufficiency
    Pascal Philibert
    Département d Hormonologie, Hopital Lapeyronie, CHU de Montpellier and Université Montpellier 1, Montpellier, France
    Fertil Steril 99:484-9. 2013
    ..To determine whether NR5A1 (SF-1) variants are a cause of primary ovarian insufficiency (POI) in 26 young women with similar genetic background...
  71. doi The p.G146A and p.P125P polymorphisms in the steroidogenic factor-1 (SF-1) gene do not affect the risk for hypospadias in Caucasians
    T Adamovic
    Department of Women s and Children s Health and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Sex Dev 6:292-7. 2012
    ..In conclusion, the SF-1 gene may not play a significant role in the development of hypospadias in Caucasians...
  72. ncbi The activation function-2 hexamer of steroidogenic factor-1 is required, but not sufficient for potentiation by SRC-1
    P A Crawford
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 11:1626-35. 1997
    The orphan receptor steroidogenic factor 1 (SF-1) plays a central role in development and differentiation of the adrenal gland and gonads...
  73. ncbi Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun
    L A Li
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
    Mol Endocrinol 13:1588-98. 1999
    Normal endocrine development and function require nuclear hormone receptor SF-1 (steroidogenic factor 1)...
  74. ncbi The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells
    Florence Gizard
    Oncology and Molecular Endocrinology Research Center, Laval University, Quebec GIK 7P4, Canada
    J Biol Chem 277:39144-55. 2002
    ..Taken together the results in this study identify a novel function of TReP-132 as a partner in a complex with SF-1 and CBP/p300 to regulate gene transcription involved in steroidogenesis...
  75. ncbi Of mice and men: The tale of steroidogenic factor-1
    J Larry Jameson
    J Clin Endocrinol Metab 89:5927-9. 2004
  76. ncbi Testicular dysgenesis without adrenal insufficiency in a 46,XY patient with a heterozygous inactive mutation of steroidogenic factor-1
    Tomonobu Hasegawa
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    J Clin Endocrinol Metab 89:5930-5. 2004
    ..The results suggest that SF-1 haploinsufficiency can selectively impair testicular development and permit the biosynthesis of AMH and testosterone in dysgenetic testes and the production of gonadotropins in pituitary gonadotropes...
  77. pmc The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
    Weiru Wang
    Plexxikon, Inc, 91 Bolivar Drive, Berkeley, CA 94710, USA
    Proc Natl Acad Sci U S A 102:7505-10. 2005
    ..These results suggest that human SF-1 and LRH-1 may be ligand-binding receptors, although it remains to be seen if phospholipids or possibly other molecules regulate SF-1 or LRH-1 under physiological conditions...
  78. ncbi Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1
    Yuka Wada
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo
    Endocr J 52:445-8. 2005
    ..The results suggest that the SF-1 Gly146Ala polymorphism may constitute a susceptibility factor for the development of S-MP, and that M-MP can be regarded as a normal variation in terms of the polymorphism effect...
  79. ncbi Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology
    Bruno Ferraz de-Souza
    UCL Institute of Child Health and Department of Medicine, University College London, UK
    Pediatr Endocrinol Rev 3:359-64. 2006
    ..the role of this transcription factor since its initial cloning in 1992, largely due to the creation of an Sf-1 (FtzF1) knockout mouse model, in vitro studies of nuclear receptor function and, more recently, following identification ..
  80. pmc Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency
    Birgit Kohler
    Department of Pediatric Endocrinology, University Children s Hospital, Charite, Humboldt University, Berlin, Germany
    Hum Mutat 29:59-64. 2008
    b>Steroidogenic factor 1 (SF1, NR5A1) is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, and the reproductive axis...
  81. ncbi SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells
    Natalia Derebecka-Holysz
    Department of Biochemistry and Molecular Biology, Medical University, 6 Swiecickiego St, Poznan, Poland
    Mol Cell Biochem 307:65-71. 2008
    ..In conclusion, our results suggest that the inhibitory action of TGF-beta on CYP17 transcription involve at least two mechanisms: SMAD3 dependent inactivation of CYP17 promoter activity and repression of SF-1 expression...
  82. pmc E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis
    Anna Ehrlund
    Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge Stockholm, Sweden
    Mol Cell Biol 29:2230-42. 2009
    ..Instead, it has acquired the capability to act as a transcriptional corepressor of steroidogenic factor 1 (SF-1)...
  83. pmc Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1
    Hidesato Ogawa
    Division of Sex Differentiation, National Institute for Basic Biology, National Institutes of Natural Sciences, Myodaiji cho, Okazaki 444 8787, Japan
    Mol Biol Cell 20:4235-45. 2009
    ..protein 4, a Rad54 family member and a SNF2 chromatin remodeling factor), which interacts with sumoylated Ad4BP/SF-1 through two SUMO-interacting motifs and one Ad4BP/SF-1-binding region...
  84. doi Three new SF-1 (NR5A1) gene mutations in two unrelated families with multiple affected members: within-family variability in 46,XY subjects and low ovarian reserve in fertile 46,XX subjects
    Diana Monica Warman
    Endocrinology Service, Hospital de Pediatria Garrahan, Buenos Aires, Argentina
    Horm Res Paediatr 75:70-7. 2011
    ..Three novel heterozygous SF-1 gene mutations affecting multiple members of two unrelated families with a history of 46,XY disorders of sex development (DSD) and 46,XX ovarian insufficiency are described...
  85. pmc ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland
    Bruno Ferraz-de-Souza
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    FASEB J 25:1166-75. 2011
    ..We have identified Ang2 as a potentially important novel target of SF-1 in the adrenal gland, indicating that regulation of angiogenesis might be an important additional mechanism by which SF-1 exerts its actions in the adrenal gland...
  86. ncbi Protein kinase A potentiates adrenal 4 binding protein/steroidogenic factor 1 transactivation by reintegrating the subcellular dynamic interactions of the nuclear receptor with its cofactors, general control nonderepressed-5/transformation/transcription d
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Mol Endocrinol 18:127-41. 2004
    The mechanism through which protein kinase A (PKA) potentiates the transactivation ability of adrenal 4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) is currently unclear...
  87. ncbi WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells
    Bilgin Gurates
    Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
    Mol Cell Endocrinol 208:61-75. 2003
    ..Given the characterized roles of these transcription factors in gonadal development and function, modulation of SF-1 action by WT1 and DAX-1 may represent an important key mechanism in steroidogenesis...
  88. ncbi Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1
    Yuka Wada
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Fertil Steril 85:787-90. 2006
    ..The results suggest that the Gly146Ala polymorphism may be a susceptibility factor for the development of cryptorchidism (CO)...
  89. ncbi SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expre
    C Aigueperse
    , , , France
    Mol Endocrinol 15:93-111. 2001
    ..Taken together, our findings suggest that detoxifying enzymes of the aldose reductase family may constitute new potential targets for regulators of adrenal and gonadal differentiation and function, e.g. SF-1 and DAX-1...
  90. ncbi Repression of the rat steroidogenic acute regulatory (StAR) protein gene by PGF2alpha is modulated by the negative transcription factor DAX-1
    T W Sandhoff
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, USA
    Endocrine 10:83-91. 1999
    ..While studies have demonstrated that steroidogenic factor 1 (SF-1) mediates transcriptional activation of the StAR gene, the mechanism for the reduction in StAR ..
  91. pmc DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita
    M Ito
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Cell Biol 17:1476-83. 1997
    ..cortex, gonads, hypothalamus, and pituitary) is the same as that of another orphan nuclear receptor, steroidogenic factor 1 (SF-1), that is required for development of the adrenal glands and gonads...
  92. ncbi Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers
    Y K Lee
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 274:20869-73. 1999
    ..These results suggest that alterations in the levels or activities of SF-1 or FTF could modulate SHP expression in appropriate tissues and thereby affect a variety of receptor dependent signaling pathways...
  93. ncbi Steroidogenic factor-1: its role in endocrine organ development and differentiation
    G D Hammer
    Department of Medicine, University of California, San Francisco, San Francisco, California, 94143 0444, USA
    Front Neuroendocrinol 20:199-223. 1999
    ..This article focuses on the characterization of SF-1 and its emerging role in endocrine homeostasis. Specific attention is placed on the mechanisms of action of this unique member of the nuclear receptor superfamily...
  94. pmc Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
    P A Crawford
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 18:2949-56. 1998
    The orphan nuclear receptor steroidogenic factor 1 (SF-1) is a critical developmental regulator in the urogenital ridge, because mice targeted for disruption of the SF-1 gene lack adrenal glands and gonads...
  95. ncbi Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita
    A T Reutens
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 84:504-11. 1999
    ..These studies reveal the variable clinical presentation of DAX-1 mutations and emphasize the value of genetic testing in boys with primary adrenal insufficiency and suspected X-linked AHC...
  96. ncbi [Recent progress in the research field of nuclear receptors]
    H Nawata
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
    Nippon Rinsho 55:2160-7. 1997
    ..Furthermore, there have been more than sixty orphan receptors identified in these eight years, including HNF, Ad4BP, DAX-1, and nur77/NGFIB, some of which are mutation target genes of human congenital diseases.
  97. pmc Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
    Z J Wang
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 98:7988-93. 2001
    ..Based on these in vivo and in vitro analyses, aromatase seems to be a physiologic target of Dax-1 in Leydig cells, and increased Cyp19 expression may account, in part, for the infertility and LCH in Dax1-deficient mice...
  98. ncbi Advances in the molecular genetics of hypogonadotropic hypogonadism
    J C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    J Pediatr Endocrinol Metab 14:3-15. 2001
    ..Furthermore, the pathophysiological basis of HHG in the majority of individuals remains unclear, despite recent advances. Other candidate genes may be involved in these patients...
  99. ncbi DAX1 gene expression upregulated by steroidogenic factor 1 in an adrenocortical carcinoma cell line
    E Vilain
    Department of Pediatrics, University of California Los Angeles School of Medicine 90095 1752, USA
    Biochem Mol Med 61:1-8. 1997
    ..b>Steroidogenic Factor 1 (SF1) regulates the expression of a number of steroidogenic genes and a putative SF1 response element (SF1-..
  100. ncbi Saccharomyces cerevisiae proteins involved in hybrid DNA formation in vitro
    W D Heyer
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
    Biochimie 73:269-76. 1991
    ..Second, an Mr 33,000 polypeptide, termed Stimulatory Factor 1 (SF1), dramatically stimulated the SEP1 catalyzed reaction by lowering the requirement for SEP1 about 300 fold...
  101. ncbi Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein
    P R Manna
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 140:1739-51. 1999
    ..expression and P production was evaluated by assessing the involvement of the nuclear orphan receptor, steroidogenic factor 1 (SF-1). Stimulation of hCG significantly elevated (2.1 +/- 0...

Research Grants62

  1. OVARIAN TUMOR NECROSIS FACTOR
    Paul Terranova; Fiscal Year: 2004
    ..Overall, these studies will provide novel insights into TNF action in regulating aromatase expression in the ovary. ..
  2. RAYMOND DANIEL BLIND; Fiscal Year: 2015
    ..The candidate will expand his research program as an independent investigator with the training afforded by this K01 award, opening new avenues to cancer research. ..
  3. Molecular Mechanisms of Gonadotrope Differentiation
    Pamela L Mellon; Fiscal Year: 2010
    ..alpha subunit shared by LH, FSH and Thyroid-Stimulating Hormone, followed by the orphan nuclear receptor Steroidogenic Factor 1, then Gonadotropin-Releasing Hormone Receptor, and finally the LH beta and FSH beta subunits...
  4. ORPHAN NUCLEAR RECEPTORS IN DEVELOPMENT AND DISEASE
    Gary Hammer; Fiscal Year: 2000
    ..In this application, I propose to examine the molecular mechanisms of SF-1 gene activation and begin to characterize the role of SF-1 in adrenal cortical cell lineage determination. ..
  5. MECHANISMS LEADING TO ADRENAL ZONATION
    William E Rainey; Fiscal Year: 2012
    ..Preliminary studies indicate that the nuclear receptor, steroidogenic factor 1 (SF-1;NR5A1) is a potent repressor of CYP11B2 but potent activator of CYP11B1...
  6. Gary D Hammer; Fiscal Year: 2014
    ..in adrenocortical subcapsular cells induces aberrant target gene activation by the nuclear receptor, steroidogenic factor 1 (SF1), and ultimate oncogenic transformation of cells within this population...
  7. Gary D Hammer; Fiscal Year: 2016
    ..Based on our preliminary data, we hypothesize that the unique and differential regulation of the Sf1 gene in fetal and adult adrenocortical cells together with paracrine signaling of the capsular/cortical unit ..
  8. Marion B Sewer; Fiscal Year: 2014
    ..This work will provide insight into multiple endocrine disorders, including adrenal hyperplasia, polycystic ovary syndrome, and Cushing's disease. ..
  9. STEPHANIE CORREA; Fiscal Year: 2015
    ..of female obesity in which the transcription factor Nkx2-1 is ablated in the ventromedial hypothalamus (VMH) using Sf1-driven CRE recombinase, Nkx2- 1Sf1Cre mice...
  10. Bradford B Lowell; Fiscal Year: 2014
    ..A group of neurons within the VMH, marked by the expression of the transcription factor, SF1 (Nr5a1), resists the development of obesity...
  11. REGULATION OF ORPHAN NUCLEAR RECEPTORS LRH-1 AND SF-1
    Robert Fletterick; Fiscal Year: 2005
    ..LRH-1 controls cholesterol and metabolism of steroid hormones. Its closest relative, steroidogenic factor 1 (SF-1), is required for proper male sexual development and affecting endocrine and neuroendocrine tissues...
  12. STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    Robert Fletterick; Fiscal Year: 2004
    ..Finally, our plans to link combinatorial chemistry with the structure and function of nuclear receptors should allow for development of new reagents with a potential use in human therapeutics. ..
  13. Structural Analyses of NR5 Orphan Nuclear Receptors
    Holly Ingraham; Fiscal Year: 2009
    ..in endocrine development and physiology with an emphasis on members of subfamily V (NR5) that includes steroidogenic factor 1 (SF-1), liver receptor homolog 1 (LRH-1) and the Drosophila Ftz-F1...
  14. Investigation of the Molecular Determinants of DAX-1 Mediated X-Linked Adrenal Hy
    Christina Tzagarakis Foster; Fiscal Year: 2009
    ....
  15. Regulation of Steroidogenic Genes by Trophic Hormones
    Marion B Sewer; Fiscal Year: 2013
    ..Mass spectrometric analysis of ligands and phospho-specific antibodies will define the relationship between signal-dependent stabilization of the interactions between SF-1 and ligand and SF-1 and coregulatory proteins. ..
  16. MECHANISMS OF ADRENAL CORTEX GROWTH/DIFFERENTIATION
    Gary Hammer; Fiscal Year: 2000
    ..As discussed in the body of this proposal, this data will provide valuable tools to allow for the search for SF- 1 target genes and cofactors important for these processes. ..
  17. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..POMC and SF1-PTP1B -/- mice (Aim #2)...
  18. Ovarian Follicular Developmental and Hormone Action
    Joanne Richards; Fiscal Year: 2007
    ..3) Determine the molecular, cellular and hormonal basis of the altered ovarian phenotype of the TAFII105 null mice. 4) Determine the function of Wnt-4 in the adult ovary. ..
  19. Lori A Setton; Fiscal Year: 2015
    ..We have experience with injectable and in situ forming elastin-like polypeptide (ELP) depots that provide for sustained local drug release...
  20. AMMY MARIE SANTIAGO; Fiscal Year: 2014
    ....
  21. David T Breault; Fiscal Year: 2016
    ..this hypothesis and established lineage conversion is dependent on the master transcriptional regulator Steroidogenic Factor 1 (SF1)...
  22. Ashutosh Chilkoti; Fiscal Year: 2015
    ..Our design of PODs is implemented by the fusion between a thermally sensitive elastin-like polypeptide (ELP) that is soluble at room temperature but forms a viscous coacervate depot upon injection at body temperature, and ..
  23. Modifying SF-1 Transcriptional Programs by Sumoylation
    EMILY JEAN FAIVRE; Fiscal Year: 2010
    ..Identification of SF-1 target genes sensitive to SUMO-modification may provide insight as to how partial loss-of function mutations in human SF-1 mediate a complete loss of function phenotype. ..
  24. REGULATION OF SF 1 EXPRESSION IN THE GONADS
    LESLIE HECKERT; Fiscal Year: 2000
    b>Steroidogenic factor 1 (SF-1), or Ad4bp, is a member of the nuclear hormone receptor family that is important for normal development and steroid hormone production...
  25. Sexually Dimorphic Regulation Of SF-1 In Gonadogenesis
    JOAN JORGENSEN; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  26. Carbon Nanotubes as Multi-functional Spectroscopic Markers and Delivery Agents fo
    Hongjie Dai; Fiscal Year: 2012
    ..Our preliminary data also indicate that paclitaxel- SWNT conjugate is superior to the Cremophor ELP solubilized paclitaxel (PTX) for cancer therapy...
  27. Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Yong Xu; Fiscal Year: 2012
    ..by one estrogen receptor isoform, ER(, expressed by specific populations of brain cells, namely POMC neurons and SF1 neurons...
  28. Yong Xu; Fiscal Year: 2015
    ..2) Actions of ER1 in another population of brain cells (SF1 neurons) are shown to increase energy expenditure, but the intracellular signaling initiated by ER1 to achieve this ..
  29. Genetically Designed Materials for Cartilage Repair
    Lori A Setton; Fiscal Year: 2010
    ..Preservation of the 3D hydrogel-forming ELP domain, together with introduction of a cell- binding domain unique to NP cells, is proposed to promote the ..
  30. Molecular Mechanisms of Atrazine in Altering the Endocrine Gene Network
    Holly A Ingraham; Fiscal Year: 2010
    ..We and others have found that ATR stimulates the nuclear receptor steroidogenic factor 1 (SF-1, NR5A1)...
  31. A Thermo-responsive Biopharmaceutical to Enhance the Tear Production of Lacritin
    Sandeep Samudre; Fiscal Year: 2013
    ..to use the temperature sensitivity of the genetically engineered smart polymer class of elastin-like polypeptides (ELP) to control ocular clearance...
  32. Wenge Liu; Fiscal Year: 2014
    ..beyond that provided by thermal coacervation will also be investigated: (1) Zn-mediated reversible crosslinking of ELP coacervates, and (2) binding of ELPs and their proteolytic fragments to extracellular matrix proteins...
  33. Molecular Mechanisms of Hormone Regulated Gene Expression in the Pituitary
    John H Nilson; Fiscal Year: 2012
    ..The studies in Aim 3 address another novel feature of 2-catenin, namely its role as a required co-activator for SF1, certainly in acting permissively to allow Lhb to respond to transcriptional cues that flow from GnRH through Egr1...
  34. Timothy M Lohman; Fiscal Year: 2015
    ..RecBCD is a hetero-trimeric complex containing two superfamily 1 (SF1) helicase/translocase motors (RecB, a 3'to 5'motor and RecD, a 5'to 3'motor) that move with ..
  35. Bradford B Lowell; Fiscal Year: 2016
    ..Our earlier studies established that POMC, AgRP and SF1 neurons are involved...
  36. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  37. Ashutosh Chilkoti; Fiscal Year: 2016
    ..In this renewal application, we seek to greatly expand upon our ability to modulate the solution behavior of ELP fusion proteins by introducing a greater level of sophistication beyond simple physical triggers of the ELP phase ..
  38. TRANSCRIPTION ACTIVATION BY HIV, TAT, HTLV TAX & HBV PX
    Michael Green; Fiscal Year: 2004
    ..The investigator has identified a Tat cofactor, Tat-SF1, and has shown that it is a general transcription elongation factor...
  39. CLARA KIELKOPF; Fiscal Year: 2016
    ..A complex of the essential splicing factors U2AF and SF1 recognizes pre-mRNA sequences adjacent the 3'splice site, and in turn stabilizes association of the core ..
  40. Molecular analysis of Elp complex function in health and disease
    Ruth N Collins; Fiscal Year: 2012
    ..Elp1p is found in a complex with five other proteins, termed the Elp complex...
  41. TRANSCRIPTIONAL REGULATION OF LH BETA GENE EXPRESSION
    Lisa Halvorson; Fiscal Year: 2003
    ..abstract_text> ..
  42. REGULATION OF LEYDIG CELL MITOSIS AND DIFFERENTIATION
    Matthew Hardy; Fiscal Year: 2003
    ....
  43. Thermally Targeted Delivery of DOX
    RAYMOND BUDDE; Fiscal Year: 2007
    ..The amino acid sequence of the designed polypeptides is based on elastin-like polypeptide (ELP) biopolymers which are soluble in aqueous solution at physiological temperature (37 [unreadable]C), but aggregate ..
  44. Structural Diversity of RNA-Binding Proteins
    Alan Frankel; Fiscal Year: 2004
    ..for mamnialian branchpoint sequences at 3' splice sites, in the context of a multiprotein complex involving SF1/mBBP. bound at the branchpoint and U2AF bound at an adjacent polypyrimidine tract and AG dincucleotide...
  45. REGULATION OF GNRH RECEPTOR GENE EXPRESSION
    Colin Clay; Fiscal Year: 2004
    ..abstract_text> ..
  46. The role of Nkx genes in hypothalamic & NAc development
    Cindy Yee; Fiscal Year: 2006
    ..1, Nkx 2.2 and Nkx2.9 and identify other developmentally regulated genes (e.g., Dlx, SF1, Shh) that colocate with Nkx genes. I will analyze the expression of these genes in Nkx2.1 mutant mice...
  47. EGR-1 AND SF-1 AND LH BETA PRODUCTION
    Yoel Sadovsky; Fiscal Year: 2003
    ..However, our results are likely to shed light on mechanisms that lead to enhanced LHbeta expression, and they may therefore provide a framework for a novel therapeutic intervention. ..
  48. Genetic Mechanisms of Mammalian Sex Determination
    KENNETH ALBRECHT; Fiscal Year: 2007
    ..In humans, heterozygous mutations in WT1 (Wilms' tumor-1) or SF1 (Steroidogenic factor-1) are associated with XY sex reversal...
  49. Mechanisms of p53 action on primate steroidogenesis
    CHARLES CHAFFIN; Fiscal Year: 2005
    ..The proposed studies are expected to demonstrate a novel role for the tumor suppressor p53 in the onset of primate and human steroidogenesis. ..
  50. SF1 & CREB: GONADAL ROLES BY A NEW TRANSGENIC APPROACH
    LESLIE HECKERT; Fiscal Year: 1999
    ..Recombination and therefore over-expression of SF-1 and CREB will occur only in Sertoli and granulosa cells of doubly transgenic mice. ..
  51. Low Cost Production of Recombinant Proteins
    SUSAN DAGHER; Fiscal Year: 2007
    ..The fundamental basis of this technology is the discovery that proteins and peptides fused to an ELP retain the environmentally triggered (temperature, salt) soluble-insoluble phase transition behavior of ELPs, and ..
  52. Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Yong Xu; Fiscal Year: 2009
    ..by one estrogen receptor isoform, ER(, expressed by specific populations of brain cells, namely POMC neurons and SF1 neurons...
  53. Smart DeltaPhase Tags for Purification of Recombinant Peptides
    SUSAN DAGHER; Fiscal Year: 2006
    ..The fundamental basis of this technology is the discovery that proteins and peptides fused to an ELP retain the environmentally triggered (temperature, salt) soluble-insoluble phase transion behavior of ELPs, and ..
  54. Splice site recognition and protein assembly
    GWENDOLYN JANG; Fiscal Year: 2009
    ..In particular, experiments will address the functional significance of SF1 and SF1 isoforms in the splicing of specific cellular pre-mRNAs and the molecular mechanisms by which SR/hnRNP ..
  55. GENE EXPRESSION IN HUMAN PARASITIC NEMATODES
    TIMOTHY NILSEN; Fiscal Year: 2009
    ..Second, the evidence indicates that SL-30 makes essential contacts with the splicing factor SF1/BBP, a protein that plays a bridging role between 5'and 3'splice sites in cis-splicing...
  56. Thermally Targeted Delivery of Therapeutic Peptides
    Drazen Raucher; Fiscal Year: 2009
    ..The amino acid sequence of the thermally responsive polypeptides is based on elastin-like (ELP) biopolymers, which are soluble in aqueous solution below physiological temperature (37 oC), but aggregate when the ..
  57. STAR AND SF-1: ESTROGEN SYNTHESIS AND BREAST CANCER RISK
    Robert Haile; Fiscal Year: 2000
    ..Steroidogenic Acute Regulatory protein (StAR) and Steroidogenic Factor- 1/Adrenal4 Binding Protein (SF-1/Ad4BP), for the presence of genetic diversity...
  58. Biopolymers for Relevant Recombinant Protein Puification
    Sue Dagher; Fiscal Year: 2004
    ..The technology relies on the use of an Elastin-Like Polypeptide (ELP) fused to the protein of interest. These tags are fused using recombinant DNA techniques...
  59. Thermally-Induced Intra-Articular Drug Delivery System
    Lori Setton; Fiscal Year: 2007
    ..drug following mixing and thermally-initiated aggregate formation (> 35 degrees C), or (2) by design of an ELP-drug fusion protein that will undergo aggregate formation when thermally-initiated...
  60. CELLULAR COACTIVATORS OF THE HIV 1 PROMOTER
    MARIANO GARCIA BLANCO; Fiscal Year: 2003
    ..CA15O associates with P-TEFb and with Tat-SF1, two other elongation factors known to play a role in HIV-1 transcription...
  61. Transcription Factor Interactions in Inhibin Regulation
    Kelly Mayo; Fiscal Year: 2002
    ..abstract_text> ..
  62. CELLULAR ORGANIZATION IN DEVELOPING HYPOTHALAMUS
    Stuart Tobet; Fiscal Year: 2002
    ..The proposed studies will bring us closer to determining the pattern-forming steps involved in the establishment of sexual differences in neural morphology and the actions of gonadal steroids on the developing nervous system. ..