sex hormone binding globulin

Summary

Gene Symbol: sex hormone binding globulin
Description: sex hormone binding globulin
Alias: ABP, SBP, TEBG, sex hormone-binding globulin, sex steroid-binding protein, testis-specific androgen-binding protein, testosterone-binding beta-globulin, testosterone-estradiol-binding globulin, testosterone-estrogen-binding globulin
Species: human

Top Publications

  1. ncbi The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs
    G L Hammond
    Department of Obstetrics and Gynecology, University of Western Ontario, Victoria Hospital, London, Canada
    Mol Endocrinol 3:1869-76. 1989
  2. ncbi Amino acid sequence of the sex steroid binding protein of human blood plasma
    K A Walsh
    Biochemistry 25:7584-90. 1986
  3. ncbi Sex hormone-binding globulin: gene organization and structure/function analyses
    G L Hammond
    MRC Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Canada
    Horm Res 45:197-201. 1996
  4. ncbi Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)
    N Fortunati
    Laboratorio di Endocrinologia, II UO ADU Medicina Generale, Azienda Ospedaliera S Giovanni B ta and Dip Fisiopatologia Clinica, Universita di Torino, Italy
    J Steroid Biochem Mol Biol 70:73-80. 1999
  5. ncbi Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
  6. ncbi Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells
    T Kalme
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN 00029 HUCH, Finland
    J Steroid Biochem Mol Biol 86:197-200. 2003
  7. ncbi Expression of sex hormone-binding globulin, oxytocin receptor, caveolin-1 and p21 in leiomyoma
    Aynur Sendemir
    Department of Obstetrics and Gynecology, HELIOS Klinikum Erfurt, Erfurt, Germany
    Gynecol Endocrinol 24:105-12. 2008
  8. pmc Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain
    I Grishkovskaya
    Forschungsgruppe Kristallographie, Max Delbruck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13092 Berlin, Germany
    EMBO J 19:504-12. 2000
  9. ncbi Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effector
    Daniel J Hryb
    Department of Medicine, St Luke s Roosevelt Hospital Center, and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Biol Chem 277:26618-22. 2002
  10. ncbi The biological variation of sex hormone-binding globulin in type 2 diabetes: implications for sex hormone-binding globulin as a surrogate marker of insulin resistance
    Vijay Jayagopal
    Diabetes Care 27:278-80. 2004

Research Grants

  1. Kathryn M Rexrode; Fiscal Year: 2016
  2. Clinical Correlates of High and Low Testosterone in Women: Framingham Heart Study
    Andrea Coviello; Fiscal Year: 2012
  3. JENNIFER SHUWEN LEE; Fiscal Year: 2015
  4. Daniel S McConnell; Fiscal Year: 2016
  5. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
  6. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
  7. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
  8. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
  9. Radoslav Goldman; Fiscal Year: 2016
  10. INHIBIN GENE EXPRESSION IN TESTIS AND SERTOLI CELLS
    HUGH KEEPING; Fiscal Year: 1991

Detail Information

Publications263 found, 100 shown here

  1. ncbi The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs
    G L Hammond
    Department of Obstetrics and Gynecology, University of Western Ontario, Victoria Hospital, London, Canada
    Mol Endocrinol 3:1869-76. 1989
    ..Although the relative abundance of the various SHBG-related mRNAs in the testis has not been established, Northern blot analysis indicates that they are similar in size (1.6 kb) to that of hepatic SHBG mRNA...
  2. ncbi Amino acid sequence of the sex steroid binding protein of human blood plasma
    K A Walsh
    Biochemistry 25:7584-90. 1986
    The amino acid sequence of the sex steroid binding protein (SBP) from human plasma has been determined. The SBP subunit consists of a 373-residue polypeptide chain containing two disulfide bonds and three oligosaccharide chains...
  3. ncbi Sex hormone-binding globulin: gene organization and structure/function analyses
    G L Hammond
    MRC Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Canada
    Horm Res 45:197-201. 1996
    Human plasma sex hormone-binding globulin (SHBG) and testicular androgen-binding protein (ABP) are homodimeric glycoproteins with a single steroid-binding site...
  4. ncbi Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)
    N Fortunati
    Laboratorio di Endocrinologia, II UO ADU Medicina Generale, Azienda Ospedaliera S Giovanni B ta and Dip Fisiopatologia Clinica, Universita di Torino, Italy
    J Steroid Biochem Mol Biol 70:73-80. 1999
    Plasma sex hormone-binding globulin (SHBG or SBP), the specific carrier for estradiol and androgens, after binding to its membrane receptor (SHBG-R), causes a significant increase of cAMP in the presence of estradiol, in both breast (MCF-..
  5. ncbi Sex hormone-binding globulin as a marker of the effect of hormonal treatment in Turner's syndrome
    R Hampl
    Institute of Endocrinology, 119 94 Praha, Czech Republic
    Endocr Regul 35:17-24. 2001
    ..Limited data on SHBG levels in these patients and only scarce reports on other than gonadal steroids in these patients are available so far. The major aim of this study was to find out whether SHBG does respond to GH treatment...
  6. ncbi Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells
    T Kalme
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN 00029 HUCH, Finland
    J Steroid Biochem Mol Biol 86:197-200. 2003
    ..We conclude that IGFBP-1 and SHBG are equally sensitive to ambient insulin concentrations in human hepatoma cell cultures, and the production of both proteins is also attenuated by the IGFs...
  7. ncbi Expression of sex hormone-binding globulin, oxytocin receptor, caveolin-1 and p21 in leiomyoma
    Aynur Sendemir
    Department of Obstetrics and Gynecology, HELIOS Klinikum Erfurt, Erfurt, Germany
    Gynecol Endocrinol 24:105-12. 2008
    ..Also, a close functional interaction of OTR and caveolin-1 has been shown to modulate cell growth and proliferation...
  8. pmc Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain
    I Grishkovskaya
    Forschungsgruppe Kristallographie, Max Delbruck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13092 Berlin, Germany
    EMBO J 19:504-12. 2000
    ..In all other jellyroll proteins, this loop is well ordered. If modelled accordingly, it covers the steroid-binding site and could thereby regulate access of ligands to the binding pocket...
  9. ncbi Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effector
    Daniel J Hryb
    Department of Medicine, St Luke s Roosevelt Hospital Center, and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Biol Chem 277:26618-22. 2002
    ..These observations are consistent with the hypothesis that SHBG, destined to participate in signaling at the cell membrane, is locally regulated and produced...
  10. ncbi The biological variation of sex hormone-binding globulin in type 2 diabetes: implications for sex hormone-binding globulin as a surrogate marker of insulin resistance
    Vijay Jayagopal
    Diabetes Care 27:278-80. 2004
  11. ncbi Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 27:1036-41. 2004
    ..We assessed the association of low levels of testosterone and sex hormone-binding globulin (SHBG) with the development of the metabolic syndrome and diabetes in men...
  12. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  13. ncbi Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    Varant Kupelian
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:843-50. 2006
    ..The purpose of this analysis was to determine whether low serum sex hormone levels or clinical androgen deficiency (AD) predict the development of MetS...
  14. ncbi SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density
    A L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Division of Endocrinology, Goteborg University, Sweden
    J Clin Endocrinol Metab 91:5029-37. 2006
    ..Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity...
  15. ncbi Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility...
  16. ncbi Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, 34384 Istanbul, Turkey
    Metabolism 56:1356-62. 2007
    ..Low SHBG may be an important independent factor for cardiometabolic risk, particularly in women...
  17. pmc Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene
    David M Selva
    Department of Obstetrics and Gynecology, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Clin Invest 117:3979-87. 2007
    ..This provides a biological explanation for why SHBG is a sensitive biomarker of the metabolic syndrome and the metabolic disturbances associated with increased fructose consumption...
  18. doi Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study
    S A Paul Chubb
    PathWest, Department of Biochemistry, Fremantle Hospital, Western Australia, 6160 Australia
    Eur J Endocrinol 158:785-92. 2008
    ..As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men...
  19. pmc Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women
    Deborah J Thompson
    Cambridge University, Strangeways Research Laboratories, Worts Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3490-8. 2008
    ..Three polymorphisms within the SHBG gene have been reported to affect SHBG levels, but there has been no systematic attempt to identify other such variants...
  20. doi Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha
    David M Selva
    Child and Family Research Institute, British Columbia, Canada
    J Mol Endocrinol 43:19-27. 2009
    ....
  21. doi Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels
    F Bonnet
    Endocrinology Unit, Department of Medicine, CHU Rennes, Universite Rennes 1, Inserm U625, 35000 Rennes, France
    Eur J Endocrinol 161:81-5. 2009
    ..We investigated the association between SHBG and the risk of hyperglycemia in each sex and we determined potential interactions between SHBG and adiponectin levels in the development of dysglycemia...
  22. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  23. doi Genetic variants of sex hormone-binding globulin and their biological consequences
    Nectaria Xita
    Department of Endocrinology, University of Ioannina, Ioannina, Greece
    Mol Cell Endocrinol 316:60-5. 2010
    ..However, the weight of evidence suggests that some common genetic variants of SHBG may influence SHBG levels and in part contribute to the phenotypic expression of human diseases...
  24. doi Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer
    N Fortunati
    Laboratory of Oncological Endocrinology, AUO San Giovanni Battista, Turin, Italy
    Mol Cell Endocrinol 316:86-92. 2010
    ....
  25. pmc Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
    John R B Perry
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK
    Hum Mol Genet 19:535-44. 2010
    Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial...
  26. pmc Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men
    Chaoyang Li
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:1618-24. 2010
    ..We sought to assess the associations of testosterones and sex hormone-binding globulin (SHBG) with metabolic syndrome and insulin resistance in men...
  27. pmc Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women
    Atsushi Goto
    Department of Epidemiology, Center for Metabolic Disease Prevention, University of California, Los Angeles, USA
    Diabetes 60:269-75. 2011
    ..We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk...
  28. pmc Genetic determinants of serum testosterone concentrations in men
    Claes Ohlsson
    Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    PLoS Genet 7:e1002313. 2011
    ..rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation...
  29. pmc Sex hormone-binding globulin and type 2 diabetes mellitus
    Trang N Le
    Department of Pediatrics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Trends Endocrinol Metab 23:32-40. 2012
    ..Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM...
  30. pmc Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas ISCIII, Barcelona, Spain
    Diabetes 61:372-82. 2012
    ..Our results suggest that TNF-α plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as obesity and type 2 diabetes...
  31. ncbi Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12----p13)
    D Berube
    Department of Molecular Genetics, Laval University Medical Centre, Quebec, Canada
    Cytogenet Cell Genet 54:65-7. 1990
    ..In this way, the SHBG gene has been localized to the p12----p13 bands of chromosome 17...
  32. pmc Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis
    S Gershagen
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    Nucleic Acids Res 17:9245-58. 1989
    A genomic cosmid clone for human sex hormone binding globulin (SHBG), a liver-secreted plasma glycoprotein that binds sex steroids, was isolated with a previously characterized liver cDNA as probe...
  33. ncbi Characterization of a cDNA coding for sex steroid-binding protein of human plasma
    B G Que
    FEBS Lett 219:405-9. 1987
    ..clone previously isolated by screening a Charon 21A human liver cDNA library with rat androgen binding protein (ABP) cDNA...
  34. ncbi The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain
    G L Hammond
    FEBS Lett 215:100-4. 1987
    ..The library was screened with a radiolabeled rat androgen-binding protein (ABP) cDNA, and the abundance of SHBG cDNAs was 1 in 750,000 plaques examined...
  35. ncbi Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
    W Rosner
    Department of Medicine, St Luke s Roosevelt Hospital Center and College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
    J Steroid Biochem Mol Biol 69:481-5. 1999
    ..These and other downstream effects of this system are reviewed...
  36. ncbi A human sex hormone-binding globulin isoform accumulates in the acrosome during spermatogenesis
    David M Selva
    Department of Obstetrics and Gynecology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario N6A 4L6, Canada
    J Biol Chem 277:45291-8. 2002
    ..This is the first demonstration that human SHBG transcripts encode an SHBG isoform that remains within a cellular compartment...
  37. ncbi Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels
    Nectaria Xita
    Division of Endocrinology, University of Ioannina, Ioannina 45110, Greece
    J Clin Endocrinol Metab 88:5976-80. 2003
    ....
  38. ncbi Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis
    C Lormeau
    Department of Rheumatology, Lille University Hospital, 59037 Lille Cedex, France
    Bone 34:933-9. 2004
    ..Finally, our findings are in agreement with previous studies which suggest that serum SHBG is a new biological marker of fracture risk in men...
  39. ncbi Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort
    Christopher A Haiman
    University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90089, USA
    J Clin Endocrinol Metab 90:2198-204. 2005
    ....
  40. ncbi Identification of sex hormone-binding globulin in the human hypothalamus
    Zsofia Herbert
    Ludwig Maximilian Universitat Munchen, Department of Biology 2, Munich, Germany
    Neuroendocrinology 81:287-93. 2005
    ..The multiple localizations of SHBG suggest neurohypophyseal and neuroendocrine functions. The biochemical data suggest that CSF SHBG is of brain rather than blood origin...
  41. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  42. ncbi The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome
    Polonca Ferk
    Department of Obstetrics and Gynaecology, Division of Medical Genetics, University Medical Centre, Ljubljana, Slovenia
    Hum Reprod 22:1031-6. 2007
    ..The sex hormone-binding globulin (SHBG) gene was proposed as being a PCOS candidate gene. A possible influence of the microsatellite polymorphism (TAAAA)(n) in the SHBG gene on serum SHBG levels in PCOS patients was investigated...
  43. pmc Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20952 7234, USA
    BMC Cancer 7:60. 2007
    ..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer...
  44. doi Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression
    David M Selva
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Endocrinology 150:2183-9. 2009
    ..We conclude that PPARgamma represses human SHBG expression in liver cells, and that differences in PPARgamma levels and activity contribute directly to variations in plasma SHBG levels...
  45. pmc Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing
    Atif M Nakhla
    Department of Urology, Columbia University, New York, NY 10032, USA
    BMC Mol Biol 10:37. 2009
    ..The SHBG gene was previously shown to express a second major transcript of unknown function, derived from an upstream promoter (P(T)), and two minor transcripts...
  46. pmc Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate
    Tomàs Pinós
    Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    BMC Mol Biol 10:59. 2009
    The human Sex Hormone Binding Globulin (SHBG) gene, located at 17p13.1, comprises, at least, two different transcription units regulated by two different promoters...
  47. pmc Relationships of circulating sex hormone-binding globulin with metabolic traits in humans
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 59:3167-73. 2010
    ..In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes...
  48. pmc Diverse roles for sex hormone-binding globulin in reproduction
    Geoffrey L Hammond
    Child and Family Research Institute and Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Reprod 85:431-41. 2011
    ..The present review compares the production and functions of SHBG in different species and its diverse effects on reproduction...
  49. ncbi Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women
    Patrice Cousin
    Hospices Civils de Lyon, Fédération d endocrinologie du pôle Est, Hopital Neurologique Pierre Wertheimer, 69394 Lyon, France
    J Clin Endocrinol Metab 89:917-24. 2004
    ....
  50. ncbi Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene
    Nobuhiko Kataoka
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer 109:1296-302. 2007
    ....
  51. ncbi Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence
    K N Hogeveen
    Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario N6A 4L6, Canada
    J Biol Chem 276:36383-90. 2001
    ..Thus, a (TAAAA)(n) element within the human SHBG promoter influences transcriptional activity in HepG2 cells and may contribute to differences in plasma SHBG levels between individuals...
  52. ncbi Sex hormone-binding globulin antagonizes the anti-apoptotic effect of estradiol in breast cancer cells
    M G Catalano
    Department of Clinical Pathophysiology, University of Turin, Turin, Italy
    Mol Cell Endocrinol 230:31-7. 2005
    ..Taken together, our observations suggest that the interaction of SHBG with MCF-7 cell membranes causes inhibition of the anti-apoptotic effect of estradiol which might account for SHBG's inhibitory effect on breast cancer cell growth...
  53. ncbi A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density
    G Rannevik
    Department of Obstetrics and Gynecology, University of Lund, , Sweden
    Maturitas 21:103-13. 1995
    ..The impact of this will influence the severity of symptoms, the degree of bone loss and the need for supplementary therapy...
  54. ncbi Factors related to sex hormone binding globulin concentrations in women with anorexia nervosa
    A Tomova
    Clinical Centre of Endocrinology and Gerontology, Sofia, Bugari
    Horm Metab Res 27:508-10. 1995
    The published reports concerning serum levels of sex hormone binding globulin (SHBG) in women with anorexia nervosa are few in number and controversial...
  55. ncbi Serum sex hormone levels and renin-sodium profile in men with hypertension
    G B Phillips
    Department of Medicine, Columbia University College of Physicians and Surgeons; St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA
    Am J Hypertens 8:626-9. 1995
    ..These findings suggest that in men with hypertension, renin profile may be related to estradiol level and possibly to risk factors for MI...
  56. ncbi Chemotherapy and endocrine function in lung cancer
    U Aasebø
    Department of Chest Medicine, University Hospital of Tromsø, Norway
    Acta Oncol 28:667-9. 1989
    ..for lung cancer influenced endocrine function, we monitored thyroxine, cortisol, testosterone, sex hormone binding globulin (SHBG), estradiol, FSH, LH, and transcortin every three weeks in 12 male patients...
  57. ncbi Characterization of obese women with reduced sex hormone-binding globulin concentrations
    R Pasquali
    Istituto di Clinica Medica e Gastroenterologia, S. Orsola Hospital, University Alma Mater, Bologna, Italy
    Horm Metab Res 22:303-6. 1990
    ..40; P less than 0.005). Therefore, compared to NSO, LSO women have distinctive clinical and endocrine characteristics, namely more pronounced hyperinsulinemia, higher E1 concentrations and a central type body fat distribution...
  58. ncbi Effects of exercise training on plasma androgens in men
    J A Houmard
    Human Performance Laboratory, East Carolina University, Greenville, North Carolina
    Horm Metab Res 26:297-300. 1994
    ..05) increase in insulin sensitivity, plasma HDL cholesterol, and a decrease in plasma triglyceride and adiposity. Exercise training thus appears to reduce CAD risk irrespective of androgen concentration in men...
  59. ncbi Immunohistochemical localization of sex hormone-binding globulin in normal and neoplastic breast tissue
    G Sinnecker
    , , Germany
    Horm Metab Res 22:47-50. 1990
    ..The apparent loss of this specific cell function in infiltrating carcinomas may result from dedifferentiation and change of cell membrane properties occurring during the process of neoplastic progression...
  60. ncbi Insulin resistance, dehydroepiandrosterone sulfate and sex hormone-binding globulin in essential hypertension
    J Serrano-Gotarredona
    Department of Endocrinology, Hospital General Universitario de Alicante, Spain
    Horm Metab Res 30:153-7. 1998
    ..Serum levels of DHEA-sulfate and SHBG were measured at the beginning and at the end of the IST. The results were compared to those of a control group of 10 healthy normotensive subjects matched for age, sex and body mass index (BMI)...
  61. ncbi Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts
    D Gansser
    Lehrstuhl Organische Chemie I, , Bundesrepublik, Deutschland
    Z Naturforsch C 50:98-104. 1995
    ..were demonstrated to reduce binding activity of human SHBG. Methylation of the mixture of 3 and 4 increased its activity about 10-fold...
  62. ncbi Interaction of lignans with human sex hormone binding globulin (SHBG)
    M Schöttner
    Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany
    Z Naturforsch C 52:834-43. 1997
    ..the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule...
  63. ncbi Low sex hormone-binding globulin and testosterone levels in association with erectile dysfunction among human immunodeficiency virus-infected men receiving testosterone and oxandrolone
    Peter Wasserman
    Infectious Disease Division, Department of Medicine New York Hospital Queens, Flushing, NY, USA
    J Sex Med 5:241-7. 2008
    ..We observed reductions in testosterone and sex hormone-binding globulin (SHBG) levels, in association with complaints of erectile dysfunction, after prolonged exposure to this therapeutic regimen...
  64. ncbi Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat
    Elaine C Tsai
    Veterans Affairs Puget Sound Health Care System and the University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 27:861-8. 2004
    ....
  65. ncbi Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women
    Prema B Rapuri
    Bone Metabolism Unit, Creighton University, School of Medicine, 601 North 30th Street, Room 6718, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:4954-62. 2004
    ..Women with a serum estradiol level of less than 9 pg/ml (33 pmol/liter) are optimal candidates for estrogen therapy for osteoporosis prevention...
  66. ncbi Plasma total and glycosylated corticosteroid-binding globulin levels are associated with insulin secretion
    J M Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 84:3192-6. 1999
    ..As high plasma CBG levels have been associated with increased incidence of type 2 diabetes, this important issue merits further investigations...
  67. ncbi The within-pair resemblance in serum levels of androgens, sex-hormone binding globulin and cortisol in female obese identical twins - effect of negative energy balance induced by very low-calorie diet
    V Hainer
    Obesity Management Centre, 3rd Department of Internal Medicine, The First Medical Faculty, Charles University, Prague, Czech Republic
    Horm Metab Res 33:417-22. 2001
    ..Our results also suggest that the mechanisms controlling baseline levels of cortisol and SHBG differ from those influencing their responses to energy deficit induced by VLCD...
  68. ncbi The rabbit sex hormone-binding globulin gene: structural organization and characterization of its 5-flanking region
    Y C Ip
    Department of Zoology, University of Hong Kong, China
    Endocrinology 141:1356-65. 2000
    ....
  69. pmc Interrelation between sex hormones and plasma sex hormone-binding globulin and hemoglobin A1c in healthy postmenopausal women
    Gabrielle Page-Wilson
    Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Metab Syndr Relat Disord 7:249-54. 2009
    ....
  70. ncbi The effects of a low-fat/high-fiber diet on sex hormone levels and menstrual cycling in premenopausal women: a 12-month randomized trial (the diet and hormone study)
    Peter H Gann
    Department of Preventive Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer 98:1870-9. 2003
    ....
  71. ncbi Sex hormone-binding globulin in gestational diabetes
    J L Bartha
    Department of Obstetrics and Gynecology, University Hospital of Puerto Real, Puerto Real, Cadiz, Spain
    Acta Obstet Gynecol Scand 79:839-45. 2000
    ....
  72. ncbi Sex hormone binding globulin facilitates female sexual receptivity except when coupled to dihydrotestosterone
    Jack D Caldwell
    Department of Biomedical Sciences, University of Illinois College of Medicine, 1601 Parkview Avenue, Rockford, IL 61107 1897, USA
    Brain Res 948:102-7. 2002
    b>Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity...
  73. doi Sex hormone-binding globulin in fish gills is a portal for sex steroids breached by xenobiotics
    Solange Miguel-Queralt
    Department of Obstetrics and Gynaecology, University of British Columbia, British Columbia, Canada V5Z 4H4
    Endocrinology 149:4269-75. 2008
    ..We conclude that SHBG controls the flux of sex steroids across fish gills and that this highly specialized function can be hijacked by xenobiotic ligands of fish SHBGs...
  74. ncbi Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunction
    Claudia Panzer
    Department of Endocrinology, Boston University Medical Center, Boston, MA, USA
    J Sex Med 3:104-13. 2006
    ..OC use is associated with a decrease of androgen ovarian synthesis and an increase in the production of sex hormone-binding globulin (SHBG). There have been limited studies assessing SHBG values after discontinuation of OC use...
  75. ncbi Do differences in age specific androgenic steroid hormone levels account for differing prostate cancer rates between Arabs and Caucasians?
    Elijah O Kehinde
    Department of Surgery Division of Urology, Faculty of Medicine, Kuwait University, Kuwait
    Int J Urol 13:354-61. 2006
    ....
  76. ncbi Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment
    K Sørensen
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:3189-96. 2007
    ..The regulation of SHBG is complex and influenced by sex steroids and insulin...
  77. ncbi Correlation between plasma lipoprotein Lp(a) and sex hormone concentrations: a cross-sectional study in healthy males
    L Denti
    Chair of Gerontology and Geriatrics, University of Parma, Italy
    Horm Metab Res 26:602-8. 1994
    ....
  78. doi Association of the (TAAAA)n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations
    Mohammad Reza Safarinejad
    Private Practice of Urology and Andrology, Tehran, Iran
    J Steroid Biochem Mol Biol 123:37-45. 2011
    b>Sex hormone binding globulin (SHBG) is involved in delivering sex hormones to target tissues...
  79. doi Sex steroids and bone turnover markers in men with symptomatic vertebral fractures
    S P Tuck
    Department of Rheumatology, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK
    Bone 43:999-1005. 2008
    ..women, but the circulating, biologically active unbound fraction is influenced by the concentration of sex hormone binding globulin (SHBG)...
  80. ncbi Insulin resistance and androgens in healthy women with different body fat distributions
    Ante Ivandic
    Department of Internal Medicine, Osijek University Hospital, Osijek, Croatia
    Wien Klin Wochenschr 114:321-6. 2002
    ....
  81. ncbi Sex hormone-binding globulin expression in sea bass (Dicentrarchus labrax L.) throughout development and the reproductive season
    Solange Miguel-Queralt
    Department of Obstetrics and Gynaecology, University of British Columbia and Child and Family Research Institute, Vancouver, Canada
    Mol Cell Endocrinol 276:55-62. 2007
    ....
  82. ncbi Determination of bioavailable testosterone [non sex hormone binding globulin (SHBG)-bound testosterone] in a population of healthy French men: influence of androstenediol on testosterone binding to SHBG
    Frank Giton
    Assistance Publique Hopitaux de Paris AP HP, Biological Center of Investigations, University Hospital Group, Sud Henri Mondor, Faculte de Medecine, Creteil, France
    Clin Chem 53:2160-8. 2007
    ..The cBT depends, however, on the values of the association constants of total testosterone (TT) for sex hormone-binding globulin (SHBG; K(s)) and albumin (K(a)), and its use therefore remains controversial...
  83. ncbi Racial/ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 15:1849-55. 2006
    ..Many of the differences in endogenous postmenopausal hormonal milieu across these five racial/ethnic groups are consistent with the known differences in breast cancer incidence across these populations...
  84. ncbi Sex hormone-binding globulin, androgen-binding protein, and vitamin K-dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein
    D R Joseph
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599
    FASEB J 6:2477-81. 1992
    Androgen-binding protein (ABP) and sex hormone-binding globulin (SHBG) are extracellular steroid-binding proteins that are homologous to the COOH-terminal domain of vitamin K-dependent protein S, a protein important in blood clotting...
  85. ncbi Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men
    A W van den Beld
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 85:3276-82. 2000
    ..Non-SHBG-bound E2 seems to be the best parameter of serum bioactive E2 in describing its positive relation with BMD...
  86. ncbi Racial disparities in metabolism, central obesity, and sex hormone-binding globulin in postmenopausal women
    D M Berman
    Division of Gerontology, Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Affair Medical Center, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 86:97-103. 2001
    ..These results suggest that the metabolic relationships between total and regional obesity, glucose, and lipid metabolism with SHBG in CAU women are different from those in postmenopausal obese AA women...
  87. ncbi Osteoporosis in men: a potential role for the sex hormone binding globulin
    E Legrand
    Service de Rhumatologie, Centre Hospitalier Universitaire, Angers, France
    Bone 29:90-5. 2001
    ..It has been suggested that estrogen and sex hormone binding globulin (SHBG) play a role in regulating bone turnover and bone mass in healthy men > 65 years of age...
  88. ncbi Molecular and functional characterization of sex hormone binding globulin in zebrafish
    Solange Miguel-Queralt
    British Columbia Research Institute for Children s and Women s Health, 950 West 28th Avenue, Vancouver, British Columbia, Canada
    Endocrinology 145:5221-30. 2004
    SHBG (sex hormone binding globulin) transports androgens and estrogens in the blood of vertebrates including fish...
  89. ncbi Sea bass (Dicentrarchus labrax) sex hormone binding globulin: molecular and biochemical properties and phylogenetic comparison of its orthologues in multiple fish species
    Solange Miguel-Queralt
    Department of Obstetrics and Gynaecology, University of British Columbia, BC, Canada
    Mol Cell Endocrinol 229:21-9. 2005
    b>Sex hormone binding globulin (SHBG) binds and transports androgens and estrogens in the blood of vertebrate species including fish...
  90. ncbi The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men
    Firoozeh Mousavinasab
    Department of Public Health Science and General Practice, University of Oulu, Finland
    Endocrine 30:185-90. 2006
    ..23 vs 28 nmol/L, p = 0.025). We conclude that the 12Ala allele of PPARgamma2 may influence SHBG levels in young Finnish men...
  91. ncbi Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in Escherichia coli
    W M Lee
    Department of Zoology, University of Hong Kong, Hong Kong
    J Endocrinol 153:373-84. 1997
    b>Sex hormone binding globulin (SHBG) is a homodimeric plasma protein found in mammals that binds sex steroids with high affinity and regulates their bioavailability...
  92. ncbi Characterization of the oligosaccharides of plasma sex hormone binding globulin from noncirrhotic alcoholic patients
    L Valladares
    Laboratorio de Hormonas y Receptores, INTA, Universidad de Chile, Santiago, Chile
    Steroids 65:275-80. 2000
    ..communis-I indicated that at least the SHBG in this fraction, from alcoholics or controls, contained two glycosylation sites and that the sites were differentially glycosylated...
  93. ncbi Low levels of Sex-Hormone-Binding Globulin predict insulin requirement in patients with gestational diabetes mellitus
    H P Kopp
    Department of Medicine 1, Rudolfstiftung Hospital, Juchgasse 25, A 1030 Vienna, Austria
    Exp Clin Endocrinol Diabetes 109:365-9. 2001
    ..30; p <0.01). In summary, we found significantly lower levels of SHBG in patients with GDM, especially in those who developed severe GDM and required insulin therapy during the last months of pregnancy...
  94. ncbi Low sex hormone binding globulin is a potential marker for the metabolic syndrome in different ethnic groups
    A H Heald
    Department of Endocrinology, University of Manchester, Salford NHS Trust, Salford, UK
    Exp Clin Endocrinol Diabetes 113:522-8. 2005
    ..As ethnic differences in SHBG level closely parallel differences in insulin resistance. Its measurement may be useful in identifying individuals at particular risk of the metabolic syndrome, for early intervention...
  95. ncbi Is sex hormone-binding globulin associated with glucose tolerance?
    A McElduff
    Department of Obstetrics, Royal North Shore Hospital, St Leonards, NSW, Australia
    Diabet Med 23:306-12. 2006
    ..The aim of this study was to explore the relationship of SHBG concentration in pregnancy to insulin resistance and glucose tolerance...
  96. ncbi Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected
    J M Gomez
    Endocrinology Service and Hormonal Laboratory, Hospital Universitario de Bellvitge, Barcelona, Spain
    J Nutr Health Aging 11:60-4. 2007
    ....
  97. pmc Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women
    Fatima Nayeem
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1109, USA
    J Nutr 139:1135-42. 2009
    ....
  98. ncbi Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children
    F Gascon
    Department of Clinical Laboratory, Valle de los Pedroches Hospital, Pozoblanco, Cordoba, Spain
    Eur J Endocrinol 143:85-9. 2000
    ..We evaluated the usefulness of SHBG as an index of hyperinsulinemia and/or insulin resistance in obese children (aged 6-9 years) of both sexes and its possible influence on the androgenic status...
  99. ncbi Serum adiponectin in women with polycystic ovarian syndrome and its relation to clinical, metabolic and endocrine parameters
    L Sieminska
    Department of Pathophysiology and Endocrinology, Silesian Medical University, Zabrze, Poland
    J Endocrinol Invest 27:528-34. 2004
    ..levels of serum adiponectin and other hormones, such as androstendione, testosterone, estradiol, DHEAS, sex hormone binding globulin (SHBG), and leptin. We also analysed the correlation between serum adiponectin and free androgen index...
  100. ncbi Antiandrogens do not reverse androgen-induced inhibition of sex hormone-binding globulin levels in adult female rhesus monkeys
    R C Winneker
    Department of Pharmacology, Sterling Research Group, Rensselaer, New York 12144
    Endocrinology 125:715-20. 1989
    ..Therefore, plasma SHBG levels cannot be used as a specific indicator of androgenic or antiandrogenic activity and may not be regulated through the classical androgen receptor...
  101. ncbi Immunolocalization of sex hormone-binding globulin (SHBG) in human ovarian follicles and corpus luteum
    T Forges
    Centre d assistance médicale à la procréation, maternité régionale et universitaire, 10, rue du Dr Heydenreich, BP 4213, 54042 Nancy cedex, France
    Histochem Cell Biol 124:285-90. 2005
    ..By analogy with the testis, these results raise the question of an involvement of SHBG in the regulation of follicular maturation as well as in luteal function...

Research Grants66

  1. Kathryn M Rexrode; Fiscal Year: 2016
    ..Specifically, we will test whether testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) might mediate hormonal risk of ischemic stroke...
  2. Clinical Correlates of High and Low Testosterone in Women: Framingham Heart Study
    Andrea Coviello; Fiscal Year: 2012
    ..abstract_text> ..
  3. JENNIFER SHUWEN LEE; Fiscal Year: 2015
    ..men and women with diabetes;2) to determine if levels of circulating endogenous estrogen, androgen, and sex hormone binding globulin (SHBG) levels are associated with subsequent pre-diabetes and diabetes;and 3) across the adult lifespan ..
  4. Daniel S McConnell; Fiscal Year: 2016
    ..Through SWAN I, II and III we have shown, both cross-sectionally and longitudinally: 1) sex hormone binding globulin (SHBG) to be most strongly associated with cardiovascular risk factors, metabolic syndrome, body ..
  5. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..levels of insulin, total and free IGF-I, IGF-II, IGFBP-1 and -3, estradiol, estrone, progesterone and sex hormone binding globulin (SHBG);(ii) tumor expression of IGF-I, IGF-II, IGFBP-1 and -3 mRNA (based on RT-PCR), and of the ..
  6. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ....
  7. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...
  8. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
    ..and oxygen/glucose deprivation (OGD) injuries;(3) PS's cytoprotection requires its C-terminal sex hormone binding globulin-like (rSHBG) module, but not the N-terminal micro-PS [Gla domain, thrombin-sensitive (TSR) region, EGF1 ..
  9. Radoslav Goldman; Fiscal Year: 2016
    ..This study proposes to examine how glycosylation of sex hormone binding globulin (SHBG) affects steroid hormone signaling in prostate cancer...
  10. INHIBIN GENE EXPRESSION IN TESTIS AND SERTOLI CELLS
    HUGH KEEPING; Fiscal Year: 1991
    ..will also be compared with the mRNA levels for another Sertoli cell secreted protein, Androgen-Binding protein (ABP)...
  11. MECHANISMS OF ACTION IN DPP INTERVENTIONS
    Abbas Kitabchi; Fiscal Year: 2001
    ..Other rationales for the proposed study are that: (a) hyperandrogenism and decreased sex hormone binding globulin (SHBG) are known to be additional risk factors for development of NIDDM in certain female populations, (..
  12. Estrogen, Inflammation and Cardiovascular Risk
    David Reuben; Fiscal Year: 2003
    ..These findings may provide substantial insight into why CEE appears to promote early but protect against late cardiovascular effects. ..
  13. DETERMINANTS OF STEROID HORMONES IN BLACK AND WHITE MEN
    Susan Gapstur; Fiscal Year: 2006
    ..concentrations of 3alpha-androstanediol glucuronide (AAG), IGF-1, IGF binding protein-3 (IGFBP-3), and sex hormone binding globulin (SHBG) were measured in serially collected serum samples over an eight-year period from 624 black and ..
  14. NIA ACADEMIC AWARD--ANDROGEN ACTION IN THE ELDERLY MALE
    JOYCE TENOVER; Fiscal Year: 1992
    ..including a moderate decrease in total serum T and a larger decline in "bioavailable T" (T not bound to sex hormone binding globulin, SHBG)...
  15. In Vivo Molecular Imaging of Estrogen Receptors
    Raghavan Rajagopalan; Fiscal Year: 2006
    ..uptake of estrogen like steroidal molecules is intimately related to the binding of the steroids to sex hormone binding globulin (SHBG)...
  16. ADJUVANT TRIAL WITH SOY AFTER RADICAL PROSTATECTOMY
    Maarten C Bosland; Fiscal Year: 2010
    ....
  17. Effectiveness of Yoga on Ambulatory Blood Pressure in Patients with Pre- and Stag
    MARSHALL A HAGINS; Fiscal Year: 2012
    ..integrated practice compared to a single element of the practice (physical postures) on ambulatory blood pressure (ABP)...
  18. Hormone levels during pregnancy and maternal ovarian cancer
    Annekatrin Lukanova; Fiscal Year: 2010
    ..Observations from this study may lead to a better understanding of disease pathogenesis, and, ultimately to development of preventive interventions. ..
  19. Agonistic Stress and CVD Risk in Young Adults
    Craig K Ewart; Fiscal Year: 2010
    ..and increased vascular resistance under a structured social challenge have elevated ambulatory blood pressure (ABP) in the natural environment...
  20. Ethnicity, Stress, and LV Mass
    Carlos Jose Rodriguez; Fiscal Year: 2010
    ..Blood pressure (BP) is one of the major determinants of LVM, and 24 hour ambulatory BP (ABP) levels have been found to predict LVM better than conventional clinic BP, however it is not known if the diurnal ..
  21. Vascular Stiffness and Endothelial Cell Function in Intradialytic Hypertension
    Peter Noel Van Buren; Fiscal Year: 2011
    ..Ambulatory blood pressure (ABP) will also be measured in these subjects as a possible confounding variable for PWV...
  22. Howard D Sesso; Fiscal Year: 2016
    ..We will obtain 24-hour ambulatory BP (ABP), fasting bloods, 24-hour urines, and other clinical assessments in this EMSI subcohort...
  23. The effect of short-term aerobic training on arterial stiffness and blood pressur
    Samuel A Headley; Fiscal Year: 2012
    ..CKD patients,(b) to determine the effect of short-term aerobic training on resting and ambulatory blood pressures (ABP) in CKD patients and (c) to determine the effect of short-term aerobic training on the acute post-exercise blood ..
  24. Regulation of presympathetic RVLM neurons by cannabinoids
    ANDREI DERBENEV; Fiscal Year: 2009
    ..A multi-disciplinary approach using immunohistochemistry, in vivo renal nerve and arterial blood pressure (ABP) recordings and in vitro patch-clamp recordings of synaptic currents in identified RVLM neurons to test the ..
  25. RCT of Controlled Breathing Effects on Ambulatory BP
    Lynn Clemow; Fiscal Year: 2011
    ..a randomized controlled trial (RCT) to test the efficacy of a guided breathing intervention on ambulatory BP(ABP) in hypertensives drawn from primary care and specialty hypertension practices, using a sample size powered to ..
  26. Leslie Wolfson; Fiscal Year: 2016
    ..intensive ABP control) to mitigate the brain changes (WMHs) that are associated with impaired mobility...
  27. Victoria M Pak; Fiscal Year: 2014
    ..Cardiovascular risk measures [ambulatory blood pressure (ABP) and Pulse-Wave Velocity (PWV)] will also be obtained at this time...
  28. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
    ..Identification of these factors is important to understand the mechanisms by which they could influence breast cancer risk and ultimately to identify high-risk women for prevention strategies. ..
  29. AngII-Salt Hypertension Increases Respiratory-Vasomotor Neuron Coupling in RVLM
    Glenn M Toney; Fiscal Year: 2013
    ..Thus exaggerated respiratory-vasomotor neuron coupling is postulated to support elevated SNA and ABP in AngII-salt HTN...
  30. Hormones During Weight Loss in Breast Cancer Survivors
    Cheryl Rock; Fiscal Year: 2004
    ....
  31. PROSTATIC STEROIDS AND SECOND MESSENGERS
    William Rosner; Fiscal Year: 2001
    ....
  32. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004
    ..We have studied a transgenic mouse model that overexpresses androgen-binding protein (ABP), a secretory product of Sertoli cells...
  33. THE EPIDIDYMAL ANDROGEN MICROENVIRONMENT
    Terry Turner; Fiscal Year: 1993
    ..As a result, our attention has become focused on androgen binding protein (ABP) from the testis, not for the sake of studying ABP per se, but the for the purpose of understanding the androgen ..
  34. Characterization of Central ABP/SHBG Receptors
    Jack Caldwell; Fiscal Year: 2005
    ..Whereas the more commonly known model suggests that steroid-binding proteins such as sex hormone binding globulin (SHBG) are only made in the periphery and only deliver steroids to be passively released at the target ..
  35. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..These carcinogenic arylamines, specifically, 4-aminobiphenyl (4-ABP), beta-naphthylamine, and benzidine, are also contained in tobacco smoke, and are the most likely causative agents ..
  36. ELLEN ROSE BROOKS; Fiscal Year: 2014
    ..CV remodeling/compliance as they change over time, using a model adjusted for mGFR, hemoglobin 24hr- ambulatory BP (ABP) loads, BL casual BP load and use of BP drug therapy (class, dose, monotherapy-or combined BP medications)...
  37. Yuesheng Zhang; Fiscal Year: 2016
    ..Arylamines, 4-aminobiphenyl (ABP) in particular, are the main cause of human BC...
  38. LC-MS Analysis of DNA Adducts of Aromatic Amines: Relationship to Bladder Cancer
    Paul Vouros; Fiscal Year: 2013
    ..4-Aminobiphenyl (4-ABP), is a major carcinogen in this class of compounds and recent evidence has identified a potential relationship ..
  39. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..on genetic predisposition to cancer, we hypothesize that aromatic amine carcinogens such as 4-aminobiphenyl (ABP) present in tobacco smoke and heterocyclic amine carcinogens such as 2-amino-3-methylimidazo [4,5-f]pyridine (IQ) ..
  40. Oxidative Dysfunction of LRP at the Blood-brain Barrier in Alzheimer's Disease
    William A Banks; Fiscal Year: 2012
    ..The neurovascular hypothesis states that an impaired brain-to-blood efflux of amyloid [unreadable] protein (ABP) at the vascular blood-brain barrier (BBB) is an important mechanism underlying ABP accumulation and cognitive ..
  41. Barbara Howard; Fiscal Year: 2014
    ..evidence based practices in order to maintain professional certification through the American Board of Pediatrics (ABP)...
  42. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..S.; and (9) the population possesses unique characteristics for examining the proposed hypothesis, i.e., a stable workforce, a non-smoking group and excellent compliance rates. ..
  43. FRANK ANDREW SCANNAPIECO; Fiscal Year: 2016
    ..structure of AbpA, identify amylase binding motifs and to address the evolutionary basis for the divergence of ABP gene sequence. 3: compare the global gene expression response of S...
  44. Virginia A Moyer; Fiscal Year: 2015
    ..The American Board of Pediatrics (ABP) proposes to develop a program in collaboration with Cincinnati Children's Hospital Medical Center (CCHMC) to ..
  45. Pursuing Perfection in Pediatric Therapeutics
    CAROLE MARIE LANNON; Fiscal Year: 2010
    ..majority of the nation's pediatric practitioners and tertiary care settings (the American Board of Pediatrics (ABP;a certifying body), the National Association of Children's Hospitals and Related Institutions (NACHRI), ..
  46. AMPA Receptor Trafficking and Signaling Complexes
    Edward B Ziff; Fiscal Year: 2010
    ..We have identified three PDZ-containing proteins that associate with GluR2, ABP, GRIP and PICK1...
  47. SPERMATOGENESIS: SERTOLI-GERM CELL INTERACTION
    ANNA STEINBERGER; Fiscal Year: 1991
    ..studies have four specific aims: 1) To characterize the vectorial patterns of Sc secretions including transferring ABP'inhibin and their regulation by FSH and T at several critical periods of sexual maturation; 2) To define the ..
  48. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..nitrosamines, aflatoxins, nitrated polycyclic aromatic hydrocarbons, and arylamines such as 4-aminobiphenyl (ABP)...
  49. Sung Wan Kim; Fiscal Year: 2016
    ..Bioreducible polymer, arginated cystamine bisacrylamide hexyl (ABP) will be pegylated and conjugated with tumor-targeting peptides (ABP-PEG-Peptide)...
  50. Online Safety Assessment & Individualized Portal Reinforcing Pediatrician Advice
    BARBARA contact HOWARD; Fiscal Year: 2010
    ..b>ABP safety QI certification and sponsorships for the portal will be sought in Phase III...
  51. Small Molecule Imaging of Protease Activity
    Matthew Bogyo; Fiscal Year: 2013
    ..We believe that these reagents will expand the use of the ABP technology platform to a large number of important human diseases that involve the process of inflammation...
  52. THE ROLE OF THE SERTOLI CELL IN SPERMATOGENESIS
    Martin Dym; Fiscal Year: 1980
    ..Androgen binding protein (ABP) is produced by Stertoli cells under hormonal control, but little is known about its role in sperm maturation...
  53. NEURONAL POLARITY
    KENNETH KOSIK; Fiscal Year: 2000
    ..of a malignant melanoma cell line (M2) that lacks a major actin filament gelation protein, actin binding protein (ABP-280) and the effects of MAP2c microinjections...
  54. ABP AND THE REGULATION OF GERM CELL APOPTOSIS IN TESTIS
    Peter Petrusz; Fiscal Year: 2000
    Spermatogenesis is an androgen-dependent process and androgen-binding protein (ABP), a secretory product of Sertoli cells, is considered a mediator of androgens action on the developing germ cells...
  55. Pregnancy and Risk Factors for CVD and Type 2 Diabetes
    Erica Gunderson; Fiscal Year: 2006
    ..The study will also assess whether breastfeeding has beneficial effects on risk factors that may help prevent heart disease and diabetes in women. ..
  56. ANDORGENS IN REPRODUCTION: PRODUCTION AND ACTION
    CLYDE BARDIN; Fiscal Year: 1980
    ..Androgen binding protein (ABP) was isolated from rat testis and epididymis...
  57. B-CLASS EPHRINS IN AXON GUIDANCE
    Andrew Bergemann; Fiscal Year: 2004
    ..Further, an ephrin B2 binding protein, ABP, will be assayed for its ability to oligomerize ephrin B2...
  58. Conditioned Placebo Effects & Treatment of Hypertension
    Thomas Pickering; Fiscal Year: 2005
    ..is the gold standard for evaluating the effectiveness of any antihypertensive treatment, and placebo effects on ABP have mostly been negligible...
  59. CPP Management Information Feedback and Nursing
    Catherine Kirkness; Fiscal Year: 2007
    ..perfusion pressure (CPP) and its components, intracranial pressure (ICP) and systemic arterial blood pressure (ABP), that help prevent or reduce secondary brain injury in critically ill patients...
  60. BIOCHEMISTRY AND PHYSIOLOGY OF RODENT ABP
    BENJAMIN DANZO; Fiscal Year: 1990
    Androgen-binding protein (ABP) is a Serotoli cell product though to be involved in spermatogenesis, the acquisition of fertilizing ability by spermatozoa, and/or the regulation of epididymal function...
  61. Signaling Complexes in Renal Epithelial Cells
    Richard Miller; Fiscal Year: 2005
    ..These studies will focus on the interaction of the extracellular Ca-sensing receptor (CaR) and filamin (ABP-280), a cytoskeletal protein, in renal epithelial cells with emphasis on MTAL and INCO cells...
  62. ACTIVATION OF CARCINOGENS BY UROTHELIUM IN VITRO
    Santhanam Swaminathan; Fiscal Year: 1991
    The main objective of this project is to elucidate the biochemical mechanisms of 4-aminobiphenyl (ABP)-induced bladder carcinogenesis in humans...
  63. Dynamical Assessment of Cerebral Autoregulation
    Vera Novak; Fiscal Year: 2007
    ..3) To validate MMPF measurements using invasive measurements of intraarterial pressure (ABP), intracranial (ICP) and cerebral perfusion pressure (CPP=ABP-ICP) and BFV in 30 patients with traumatic brain ..
  64. SERUM LIGNAN AND RISK OF ENDOMETRIAL CANCER
    Anne Zeleniuch Jacquotte; Fiscal Year: 2002
    ..It is expected that approximately 300 cases will be eligible for the study. The availability of this ongoing study offers a unique opportunity to address the specific aim rapidly and at a minimal cost. ..
  65. DETERMING USUAL BP OF OLDER ADULTS IN PRIMARY CARE
    Kevin Pearce; Fiscal Year: 1993
    ..This study will use 24-hour ambulatory blood pressure (ABP) monitoring as a gold-standard to derive guidelines for the optimum determination of usual BP in the medical office...
  66. MOLECULAR BIOLOGY OF ACTIN-BINDING PROTEIN
    Jed Gorlin; Fiscal Year: 1993
    Actin-binding protein (ABP), sometimes called filamin, crosslinks actin filaments into an orthogonal array in the cortical cytoplasm, an organelle-excluding area involved in dynamic changes during cell motility...