serotonin transporter

Summary

Gene Symbol: serotonin transporter
Description: solute carrier family 6 member 4
Alias: 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Species: human

Top Publications

  1. ncbi Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 8:20-1. 2005
  2. pmc Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
    Dongsha Wang
    Sainte Justine Hospital Research Center, Montreal, Quebec, Canada
    PLoS ONE 7:e39501. 2012
  3. ncbi A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
  4. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
  5. doi The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis
    R Miller
    Department of Psychology, Technische Universitat Dresden, Dresden, Germany
    Mol Psychiatry 18:1018-24. 2013
  6. ncbi Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 127:85-9. 2004
  7. pmc Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits
    Avshalom Caspi
    Department of Psychology, and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Am J Psychiatry 167:509-27. 2010
  8. doi The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis
    S E Murphy
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Mol Psychiatry 18:512-20. 2013
  9. doi Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression
    Hee Ju Kang
    Department of Psychiatry and Clinical Depression Research Centre, Chonnam National University Medical School, Gwangju, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 44:23-8. 2013
  10. pmc Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism
    Jennifer Pacheco
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 29:6229-33. 2009

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. Elaine L Bearer; Fiscal Year: 2016
  3. Developmental effects of 5-HTT genotype on stress reactivity and brain function
    Moriah E Thomason; Fiscal Year: 2010
  4. Antidepressant Therapy for Functional Dyspepsia
    YURI ANN SAITO LOFTUS; Fiscal Year: 2011
  5. Nelly Alia-Klein; Fiscal Year: 2014
  6. Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
  7. Ming D Li; Fiscal Year: 2016
  8. Unraveling the Genetic Etiology of Autism
    James S Sutcliffe; Fiscal Year: 2010
  9. Helen M Pettinati; Fiscal Year: 2016
  10. [F-18]Mefway PET to measure 5-HT1A receptors in gene x environment interactions
    BRADLEY CHRISTIAN; Fiscal Year: 2010

Detail Information

Publications379 found, 100 shown here

  1. ncbi Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Nat Neurosci 8:20-1. 2005
    Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4)...
  2. pmc Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
    Dongsha Wang
    Sainte Justine Hospital Research Center, Montreal, Quebec, Canada
    PLoS ONE 7:e39501. 2012
    ..This supports the relevance of peripheral DNA methylation for brain function and suggests that peripheral SLC6A4 DNA methylation could be a marker of central 5-HT function...
  3. ncbi A susceptibility gene for affective disorders and the response of the human amygdala
    Ahmad R Hariri
    Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:146-52. 2005
    A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety ..
  4. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression...
  5. doi The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis
    R Miller
    Department of Psychology, Technische Universitat Dresden, Dresden, Germany
    Mol Psychiatry 18:1018-24. 2013
    Recent meta-analyses have stimulated an active debate on whether the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with an elevated vulnerability to psychiatric diseases upon exposure to environmental ..
  6. ncbi Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 127:85-9. 2004
    ..At least 26 studies have investigated a putative association between a functional serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits...
  7. pmc Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits
    Avshalom Caspi
    Department of Psychology, and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Am J Psychiatry 167:509-27. 2010
    ..review research about one of the most extensive areas of inquiry: variation in the promoter region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to stress sensitivity...
  8. doi The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis
    S E Murphy
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Mol Psychiatry 18:512-20. 2013
    ....
  9. doi Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression
    Hee Ju Kang
    Department of Psychiatry and Clinical Depression Research Centre, Chonnam National University Medical School, Gwangju, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 44:23-8. 2013
    ..In 108 patients with major depressive disorders, the methylation status in the promoter of gene encoding serotonin transporter (SLC6A4) was measured...
  10. pmc Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism
    Jennifer Pacheco
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 29:6229-33. 2009
    Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural activity in limbic and prefrontal regions in response to emotional stimuli...
  11. ncbi Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
    J R Wendland
    Mol Psychiatry 11:224-6. 2006
  12. pmc Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli
    Christopher G Beevers
    Department of Psychology, University of Texas at Austin, Texas 78712, USA
    J Abnorm Psychol 118:670-81. 2009
    A deletion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has been associated with vulnerability to affective disorders, yet the mechanism by which this gene confers vulnerability remains unclear...
  13. ncbi 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    Carriers of the short allele of a functional 5' promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression...
  14. pmc The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:543-9. 2008
    b>Serotonin Transporter (5HTT or SLC6A4) mRNA transcription is regulated by both genetic and epigenetic mechanisms...
  15. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    The 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of emotional response after stressful life events...
  16. pmc Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins
    I Ouellet-Morin
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 43:1813-23. 2013
    ..Method We tested whether bullying victimization influenced serotonin transporter gene (SERT) DNA methylation using a discordant monozygotic (MZ) twin design...
  17. doi 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls
    Eva Friedel
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 205:261-71. 2009
    ..This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-..
  18. ncbi Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation
    Andreas Heinz
    Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    Biol Psychiatry 61:1011-4. 2007
    A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala...
  19. pmc Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF
    Fahad R Ali
    School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Neurochem 112:296-306. 2010
    Two distinct variable number tandem repeats (VNTRs) within the human serotonin transporter gene (SLC6A4) have been implicated as predisposing factors for CNS disorders...
  20. pmc The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review
    R Kathryn McHugh
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Drug Alcohol Depend 108:1-6. 2010
    Previous studies have implicated a relationship between particular allelic variations of the serotonin transporter gene (5HTTLPR) and alcohol dependence...
  21. doi Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis
    H Clarke
    Department of Experimental Psychology, University of Bristol, UK
    Psychol Med 40:1767-78. 2010
    ..We sought to ascertain the strength of evidence for association between the 5-HTTLPR polymorphism and unipolar depression...
  22. pmc Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene
    Moriah E Thomason
    Department of Psychology, Stanford University, Stanford, CA 94305, USA
    Biol Psychol 85:38-44. 2010
    Recent evidence suggests that a genetic polymorphism in the promoter region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) mediates stress reactivity in adults...
  23. pmc The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces
    Elisabeth A H von dem Hagen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 49:674-80. 2011
    Previous research has found that a common polymorphism in the serotonin transporter gene (5-HTTLPR) is an important mediator of individual differences in brain responses associated with emotional behaviour...
  24. ncbi The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  25. doi Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Albert Schweitzer Str 11, 48149 Munster, Germany
    Neuroimage 53:893-8. 2010
    A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to modulate amygdala responsiveness to negative environmental cues...
  26. ncbi Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety
    Tomoko Mizuno
    Tohoku University Graduate School of Medicine, Sendai, Japan
    J Psychosom Res 60:91-7. 2006
    The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress.
  27. pmc Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
    Marian J Bakermans-Kranenburg
    Centre for Child and Family Studies, Leiden University, PO Box 9555, NL 2300 RB Leiden, The Netherlands
    Soc Cogn Affect Neurosci 3:128-34. 2008
    ..We examined the role of serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes in explaining differences in sensitive parenting in a community ..
  28. pmc Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma
    Marinus H van IJzendoorn
    Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands
    Biol Psychiatry 68:405-7. 2010
    ..Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences?..
  29. ncbi A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety
    J A Schinka
    Veteran s Administration Medical Center, Tampa, FL 33612, USA
    Mol Psychiatry 9:197-202. 2004
    Studies of the association between polymorphisms of the serotonin transporter gene (5-HTT) and trait anxiety have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions ..
  30. ncbi Meta-analysis of serotonin transporter polymorphisms and affective disorders
    Francis E Lotrich
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Psychiatr Genet 14:121-9. 2004
    Polymorphisms in the promoter region (5-HTTLPR) of the serotonin transporter and a variable number of tandem repeats polymorphism in the second intron have been widely studied...
  31. ncbi 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression
    Udo Dannlowski
    1 1Department of Psychiatry, University of Munster, Munster, Germany 2 2IZKF Research Group 4, IZKF Münster, University of Munster, Munster, Germany
    Neuropsychopharmacology 33:418-24. 2008
    ..amygdala activity during conscious emotion processing is modulated by a functional polymorphism in the serotonin transporter gene (5-HTTLPR) in healthy subjects...
  32. pmc Looking on the bright side: biased attention and the human serotonin transporter gene
    Elaine Fox
    Department of Psychology, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Proc Biol Sci 276:1747-51. 2009
    ..Here we show for the first time that allelic variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is associated with differential biases for positive and negative affective pictures...
  33. pmc Genetic contributions of the serotonin transporter to social learning of fear and economic decision making
    Liviu G Crişan
    Department of Psychology, Babes Bolyai University, 400015 Cluj Napoca, Romania
    Soc Cogn Affect Neurosci 4:399-408. 2009
    ..the effects of a functional polymorphism in the regulatory region (5-HTTLPR) of the human 5-HT transporter (5-HTT) gene on observational FC, risk taking and susceptibility to framing in decision making under uncertainty, as well ..
  34. doi Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder
    Richard A Bryant
    School of Psychology, University of New South Wales, Sydney, Australia
    Biol Psychiatry 67:1217-9. 2010
    This study was intended to assess the extent to which the low-expression alleles of the serotonin transporter gene promoter predict poor response to cognitive behavior therapy in patients with posttraumatic stress disorder (PTSD).
  35. pmc Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task
    Turhan Canli
    Department of Psychology and Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794 2500, USA
    Proc Natl Acad Sci U S A 102:12224-9. 2005
    ..within the repetitive sequence in the transcriptional control region of the serotonin (5-HT) transporter gene (5-HTT, SLC6A4) in modulating amygdala and prefrontal activation to negative emotional stimuli...
  36. pmc 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 150:271-81. 2009
    ..There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately...
  37. ncbi Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    Substantial evidence supports a role for dysfunction of the serotonin transporter in the pathogenesis of major depression...
  38. pmc Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, USA
    Mol Psychiatry 12:544-55. 2007
    The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety...
  39. ncbi [Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population]
    Shun wen Luo
    Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
    Beijing Da Xue Xue Bao 43:514-8. 2011
    ..To investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTPLR) and the clinical characters of premature ejaculation in Han Chinese population...
  40. doi The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptoms
    Divya Mehta
    Max Planck Institute of Psychiatry, Munich, Germany
    J Affect Disord 136:1192-7. 2012
    ..The aim of this study was to evaluate the influence of stressful life events in combination with the serotonin transporter gene 5-HTTLPR polymorphism on peripartum depressive symptoms.
  41. pmc Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles
    M Wankerl
    Department of Biopsychology, Technische Universitat Dresden, Dresden, Germany
    Transl Psychiatry 4:e402. 2014
    The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression...
  42. pmc The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism
    Zhewu Wang
    Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Depress Anxiety 28:1067-73. 2011
    ..The serotonin transporter (5-HTT) gene (SLC6A4) has been identified as a prime candidate for the development of the disorder, as 5-..
  43. pmc Amygdala response to smoking-cessation messages mediates the effects of serotonin transporter gene variation on quitting
    Agnes J Jasinska
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 60:766-73. 2012
    ..We further show that the amygdala response is modulated by genetic variation in the serotonin transporter and mediates the impact of this genetic variation on quitting...
  44. pmc Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization
    S Ramamoorthy
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912 2100
    Proc Natl Acad Sci U S A 90:2542-6. 1993
    ..The brain 5HT transporter appears to be a principal site of action of therapeutic antidepressants and may mediate behavioral and/or ..
  45. doi Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety
    Diana Armbruster
    Institute of Psychology II, Dresden University of Technology, Dresden, Germany
    Int J Neuropsychopharmacol 12:393-401. 2009
    Genetic variation of the serotonin transporter (5-HTT) has been associated with fear- and anxiety-related behaviours...
  46. doi Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008
    ..Our PET studies revealed that the serotonin transporter (5-HTT) density in global brain regions is significantly lower in MAP abusers...
  47. pmc Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder
    Tomas Furmark
    Department of Psychology, Uppsala University, Uppsala, Sweden
    J Psychiatry Neurosci 34:30-40. 2009
    ..We investigated the influence of these polymorphisms on amygdala responsiveness to angry faces in patients with social anxiety disorder (SAD) compared with healthy controls...
  48. doi Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention
    S Fukudo
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neuroimage 47:946-51. 2009
    ..The amygdala is more activated during fearful face recognition in individuals with the s allele of 5-HTTLPR. Here, we tested our hypothesis that 5-HTTLPR differentially activates brain regions with colorectal distention in humans...
  49. pmc Serotonin transporter gene, depressive symptoms, and interleukin-6
    Shaoyong Su
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Cardiovasc Genet 2:614-20. 2009
    We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (IL-6) levels.
  50. pmc Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology
    Dante Cicchetti
    Mt Hope Family Center, University of Rochester, NY, USA
    Dev Psychopathol 23:1125-38. 2011
    ..Variation in the corticotropin releasing hormone receptor 1 (CRHR1) TAT haplotype and serotonin transporter linked polymorphic region (5-HTTLPR) was determined in a sample of maltreated (n = 238, 21...
  51. pmc Association study of serotonin transporter gene polymorphisms with obstructive sleep apnea syndrome in Chinese Han population
    Weihua Yue
    Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, PR China
    Sleep 31:1535-41. 2008
    Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the ..
  52. doi 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Heidelberg, Germany
    Eur J Gastroenterol Hepatol 22:856-61. 2010
    Conflicting data exist on the association between functional polymorphisms in the serotonin reuptake transporter (SERT) gene (SLC6A4) and irritable bowel syndrome (IBS)...
  53. pmc Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli
    Tracy Kwang
    University of Texas at Austin, 78712 0187, USA
    Depress Anxiety 27:746-51. 2010
    ..Biased attention for emotional stimuli reflects vulnerability or resilience to emotional disorders. The current study examines whether the 5-HTTLPR polymorphism is associated with attentional biases for negative word stimuli...
  54. doi Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population
    M Aguilera
    Unitat d Antropologia, Departament Biologia Animal, Facultat de Biologia, Universitat de Barcelona and CIBER de Salud Mental, Instituto de Salud Carlos III, Spain
    Psychol Med 39:1425-32. 2009
    ..b>Serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult ..
  55. doi Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression
    Nina Alexander
    Center for Psychobiology and Behavioral Medicine, University of Giessen, Department of Psychology, FRG, Otto Behaghel Str 10, D 35394 Giessen, Germany
    Psychoneuroendocrinology 34:1294-303. 2009
    Growing evidence suggests that the serotonin transporter polymorphism (5-HTTLPR) interacts with adverse environmental influences to produce an increased risk for the development of depression while the underlying mechanisms of this ..
  56. doi Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial
    Glyn Lewis
    School of Social and Community Medicine, University of Bristol, UK
    Br J Psychiatry 198:464-71. 2011
    ..We wished to investigate whether genetic variation could be used to target or personalise treatment, in a comparison of selective serotonin reuptake inhibitors (SSRIs) with noradrenaline reuptake inhibitors (NARIs)...
  57. pmc Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results
    Rudolf Uher
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    J Affect Disord 135:56-65. 2011
    ....
  58. ncbi Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia
    J B Fan
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:928-38, 891. 2005
    The serotonin transporter gene (SLC6A4) is a candidate gene for schizophrenia based on serotonin transporter's crucial role in serotonergic neurotransmission...
  59. ncbi Genetic variation in serotonin transporter alters resting brain function in healthy individuals
    Hengyi Rao
    Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Biol Psychiatry 62:600-6. 2007
    Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals.
  60. pmc Genetic determinants of financial risk taking
    Camelia M Kuhnen
    Kellogg School of Management, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 4:e4362. 2009
    ..DRD4 7-repeat allele carriers take 25% more risk than individuals without the 7-repeat allele. These findings contribute to the emerging literature on the genetic determinants of economic behavior...
  61. doi Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain
    N V Murthy
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Neuroimage 52:50-4. 2010
    Studies in vitro suggest that the expression of the serotonin transporter (5-HTT) is regulated by polymorphic variation in the promoter region of the 5-HTT gene (5-HTTLPR); however, results from human brain imaging studies examining the ..
  62. ncbi Polymorphism in serotonin transporter gene associated with susceptibility to major depression
    A D Ogilvie
    Medical Research Council, Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh, UK
    Lancet 347:731-3. 1996
    BACKGROUND; The serotonin transporter of the brain provides the primary target for the action of selective antidepressant drugs...
  63. ncbi The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder
    Barbara Hoefgen
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 57:247-51. 2005
    ..A 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), which influences expression of the serotonin transporter, has been the focus of intensive ..
  64. ncbi A study of candidate genotypes associated with dyspepsia in a U.S. community
    Christopher E Camilleri
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 101:581-92. 2006
    ..The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNbeta3...
  65. ncbi Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds
    Dante Cicchetti
    Institute of Child Development and Department of Psychiatry, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
    Dev Psychopathol 19:1161-80. 2007
    Child maltreatment and polymorphisms of the serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) genes were examined in relation to depressive symptomatology. Adolescents (M age = 16...
  66. doi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25...
  67. pmc AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance
    Rachel Bachner-Melman
    Department of Psychology, Mount Scopus, Hebrew University, Jerusalem, Israel
    PLoS Genet 1:e42. 2005
    ..In the current study, 85 current performing dancers and their parents were genotyped for the serotonin transporter (SLC6A4: promoter region HTTLPR and intron 2 VNTR) and the arginine vasopressin receptor 1a (AVPR1a: ..
  68. ncbi Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island
    Robert Philibert
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 144:101-5. 2007
    The serotonin reuptake transporter (5HTT) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness...
  69. doi Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation
    Paddy K C Janssen
    Section of Psychopharmacology, Department of Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands
    J Sex Med 6:276-84. 2009
    ....
  70. pmc Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans
    Eva Kosek
    Osher Center for Integrative Medicine, Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Sweden
    Mol Pain 5:37. 2009
    ..The serotonin transporter (5-HTT) is a key regulator of serotonin metabolism and availability and its gene harbors several known ..
  71. doi Prospects for epigenetic research within cohort studies of psychological disorder: a pilot investigation of a peripheral cell marker of epigenetic risk for depression
    C A Olsson
    Murdoch Childrens Research Institute, Parkville 3052 Victoria, Australia
    Biol Psychol 83:159-65. 2010
    ..Epigenotyping was limited to promoter methylation of the serotonin transporter gene (5HTT). A transcription limiting VNTR in the 5HTT promoter (5HTTLPR) was also genotyped...
  72. pmc Childhood stress, serotonin transporter gene and brain structures in major depression
    Thomas Frodl
    Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neuropsychopharmacology 35:1383-90. 2010
    ..hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects...
  73. pmc Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Biol Psychiatry 63:852-7. 2008
    We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship.
  74. ncbi Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
    ..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
  75. ncbi Association of serotonin transporter genotype with selective processing of smoking-related stimuli in current smokers and ex-smokers
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, United Kingdom
    Nicotine Tob Res 7:773-8. 2005
    We sought to determine whether polymorphism in the serotonin transporter (5HTT) gene is associated with attentional bias toward smoking-related stimuli in current smokers and ex-smokers, using a modified Stroop task and an attentional ..
  76. pmc Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Psychiatry 164:1379-84. 2007
    The short allele of a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with stressful life events to predict depression in otherwise healthy individuals...
  77. pmc Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers
    Lea R Dougherty
    Department of Psychology, Stony Brook University, NY, United States
    Biol Psychol 83:93-100. 2010
    This study examined whether the interaction between the serotonin transporter promoter region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms was associated with hypothalamic-pituitary-adrenal (HPA) axis ..
  78. pmc Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population
    Fumihiko Toyoshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    BMC Med Genet 12:88. 2011
    ..In the present study, the association between serotonin transporter (SERT) gene (SLC6A4) polymorphism and FD was explored.
  79. pmc Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress
    Emily M Drabant
    Department of Psychology, Stanford University, Stanford, California, USA
    Am J Psychiatry 169:397-405. 2012
    ....
  80. ncbi Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls
    Sunil Kumar
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow 226014, UP, India
    J Gastrointestin Liver Dis 21:31-8. 2012
    Polymorphisms in serotonin re-uptake transporter (SERT or SLC6A4) gene may play role in disturbance in gut function in irritable bowel syndrome (IBS)...
  81. doi A reassessment of the possible effects of the serotonin transporter gene linked polymorphism 5-HTTLPR on premature ejaculation
    Patrick Jern
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Arch Sex Behav 42:45-9. 2013
    ....
  82. doi Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression
    Pei Shen Ho
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Psychiatry Res 212:216-22. 2013
    The serotonin transporter (SERT) is hypothesized to be an important component of the pathophysiology of major depression (MD)...
  83. pmc A serotonin transporter gene (SLC6A4) polymorphism is associated with reduced risk of irritable bowel syndrome in American and Asian population: a meta-analysis
    Mohammed Y Areeshi
    Department of Medical Microbiology, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia
    PLoS ONE 8:e75567. 2013
    Association studies of serotonin transporter gene SLC6A4 I/S polymorphism and irritable bowel syndrome (IBS) have shown inconsistent and contradictory results among different populations...
  84. pmc Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis
    Scott V Adams
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biophys J 85:1548-59. 2003
    We have investigated the conduction states of human serotonin transporter (hSERT) using the voltage clamp, cut-open frog oocyte method under different internal and external ionic conditions...
  85. ncbi Association of serotonin transporter gene polymorphism with obstructive sleep apnea syndrome
    Metin Ylmaz
    Department of Otolaryngology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey
    Laryngoscope 115:832-6. 2005
    ..The synaptic 5-hydroxytryptamine (HT) is inactivated by presynaptic reuptake, which is mediated by the serotonin transporter. Blockage of the serotonin transporter leads to increased extracellular 5-HT...
  86. ncbi Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia
    Pilar A Saiz
    Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería 6 3 degrees, 33006 Oviedo, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 31:741-5. 2007
    ..i) the association between four serotonergic polymorphisms (A-1438G and T102C of the 5-HT2A receptor gene, and 5-HTT VNTR and 5-HTTLPR of the 5-HT transporter gene) and schizophrenia and (ii) the potential interaction of those ..
  87. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ..The current study compared serotonin transporter (5-HTT) binding between unipolar-depressives (MDD), bipolar-depressives (BD) and healthy-controls (HC) to ..
  88. pmc Candidate genes and sensory functions in health and irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Mayo Clinic, Charlton 8 110, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 295:G219-25. 2008
    ....
  89. doi The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Psychiatr Genet 18:184-90. 2008
    b>Serotonin transporter gene (SLC6A4) variations have been proposed as an explanation for interindividual differences in selective serotonin reuptake inhibitors (SSRIs) effects...
  90. pmc 5-HTTLPR genotype influences amygdala volume
    Harald Scherk
    AMEOS Klinikum Osnabrück, Knollstr 31, 49088, Osnabruck, Germany
    Eur Arch Psychiatry Clin Neurosci 259:212-7. 2009
    ....
  91. pmc The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
    Sonja Sucic
    Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
    J Biol Chem 286:16482-90. 2011
    The transporters for serotonin (SERT), dopamine, and noradrenaline have a conserved hydrophobic core but divergent N and C termini...
  92. doi Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome
    T Markoutsaki
    2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece
    Dig Dis Sci 56:3276-80. 2011
    Polymorphisms in the serotonin transporter (SERT) and G protein β3 subunit (GNB3) genes might contribute to the pathophysiology of irritable bowel syndrome (IBS)...
  93. pmc No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression
    J Cole
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
    Genes Brain Behav 10:756-64. 2011
    ..Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on ..
  94. doi Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females
    Jamie Vaske
    Department of Criminology and Criminal Justice, Western Carolina University, 410 A Belk, Cullowhee, NC 28723, USA
    Dev Psychopathol 24:181-93. 2012
    ..The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of ..
  95. doi No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls
    Daniela Zuccarello
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Sex Med 9:1659-68. 2012
    ..Recently, genetic polymorphisms located on SLC6A4 gene codifying for 5-HT transporter (5-HTT or serotonin transporter [SERT]), the major regulator of serotonergic neurotransmission, have been linked with the pathogenesis of ..
  96. pmc BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
    Antonio Terracciano
    National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 35:1083-9. 2010
    ..Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333)...
  97. doi Social constraints, genetic vulnerability, and mental health following collective stress
    E Alison Holman
    Programin Nursing Science, University of California, Irvine 92697, USA
    J Trauma Stress 24:497-505. 2011
    ..Constraints on disclosing fears about future terrorism moderate the 5-HTTLPR genotype-PTS symptom association even when indirectly exposed to collective stress...
  98. ncbi Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population
    N Narita
    Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
    Pediatrics 107:690-2. 2001
    ..Variations in the promoter region of the 5-HT transporter (5-HTT) gene have been shown to potentially regulate 5-HT activity in the brain...
  99. ncbi Perceived parenting behavior in the childhood of cocaine users: relationship with genotype and personality traits
    G Gerra
    Centro Studi Farmaco tossicodipendenze, Ser T, AUSL, Parma, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:52-7. 2007
    ..In the present study, parents care perception, aggressive personality traits, and genotype (serotonin transporter promoter gene--5-HTTLPR) have been investigated in cocaine users and healthy control subjects...
  100. ncbi A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
    Y A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:465-70. 2007
    A pharmacogenetic study suggests the 5-HTT LPR polymorphism predicts response to alosetron, and another study describes a possible association of the GNbeta3 C825T polymorphism with IBS in patients with dyspepsia...
  101. pmc Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder
    Jennifer Y F Lau
    Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 65:349-55. 2009
    Associations between a functional polymorphism in the serotonin transporter gene and amygdala activation have been found in healthy, depressed, and anxious adults...

Research Grants76

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Elaine L Bearer; Fiscal Year: 2016
    ..Genetic studies show an association with polymorphisms in the serotonin transporter (SERT, 5-HTT) gene with risk of affective disorders including PTSD...
  3. Developmental effects of 5-HTT genotype on stress reactivity and brain function
    Moriah E Thomason; Fiscal Year: 2010
    ..Despite the successful characterization of the brain phenotype associated with the allele structure of the serotonin transporter (5-HTT) gene (SLC6A4) in adults, little is known about the developmental emergence of these phenotypes or ..
  4. Antidepressant Therapy for Functional Dyspepsia
    YURI ANN SAITO LOFTUS; Fiscal Year: 2011
    ..3) The serotonin transporter long homozygous polymorphism will predict a significantly poorer symptom response to escitalopram and ..
  5. Nelly Alia-Klein; Fiscal Year: 2014
    ..Other monoamine regulators, such as catechol-O-methyltransferase (COMT) and the serotonin transporter (5-HTT), together with MAO A, are also implicated as neurochemical markers in the study and treatment of ..
  6. Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys
    GREGORY MICHAEL MILLER; Fiscal Year: 2013
    ..I will systematically uncover functionally comparable polymorphisms in rhesus monkey serotonin transporter (SERT), tryptophan hydroxylase 2 (TPH2) and monoamine oxidase A (MAOA) genes, and assess genotype/..
  7. Ming D Li; Fiscal Year: 2016
    ..was efficacious in reducing drinking among individuals homozygous for the L allele of the 52-HTTLPR in the serotonin transporter gene (SLC6A4), an effect that was enhanced in individuals who were T homozygotes for the 32-UTR SNP (..
  8. Unraveling the Genetic Etiology of Autism
    James S Sutcliffe; Fiscal Year: 2010
    ..The 5-HT transporter (SERT) and 5-HT1A receptor are lynchpins in the control of serotonin concentration and function in the CMS, and emerging ..
  9. Helen M Pettinati; Fiscal Year: 2016
    ..was efficacious in reducing drinking among individuals homozygous for the L allele of the 52-HTTLPR in the serotonin transporter gene (SLC6A4), an effect that was enhanced in individuals who were T homozygotes for the 32-UTR SNP (..
  10. [F-18]Mefway PET to measure 5-HT1A receptors in gene x environment interactions
    BRADLEY CHRISTIAN; Fiscal Year: 2010
    ..Particularly, to examine if carriers with a short variation of the gene for encoding the serotonin transporter are more profoundly affected by prenatal stress than those with long gene variation...
  11. Maternal flu infection and brain development in primates
    Christopher L Coe; Fiscal Year: 2010
    ..The emphasis of the new aim is on this polymorphism in the promoter region of the serotonin transporter gene, but as a part of the supplement effort, we will extract and archive DNA for all study animals, to ..
  12. Chamindi Seneviratne; Fiscal Year: 2016
    ..The scientific goal of the K23 application is to develop a novel genomic biomarker combination (Serotonin transporter gene (SERT) mRNA expression levels in 5'-HTTLPR-LL genotype carriers) for quantitatively predict ..
  13. Huong Q Nguyen; Fiscal Year: 2014
    ..serotonin which is involved in the pathophysiology of affective disorders is regulated by the serotonin transporter (SERT) that controls reuptake of serotonin at brain synapses...
  14. A NURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMEN
    Margaret McLean Heitkemper; Fiscal Year: 2013
    ..Psychological distress, the autonomic nervous system and serotonin transporter protein polymorphisms may serve as biomarkers of symptom type and severity in women with IBS...
  15. Hot Flushes and SNPs of the Norepinephrine and Serotonin Transporter Genes
    ISTVAN JOZSEF MERCHENTHALER; Fiscal Year: 2012
    ..Our hypothesis is that the heterogenouos response is due to single nucleotide polymorphisms of the serotonin transporter (SERT) and/or the norepinephrine transporter (NET) genes...
  16. In Vivo Detection of Neuronal Activity
    Russell E Jacobs; Fiscal Year: 2010
    ..DTI in: C57BL/6J mice to determine normal anatomy and activity; dopamine (DAT), norepinephrine (NET) and serotonin transporter (SERT) knockouts; dopamine D1 a and D2 receptor knockouts; catechol-O-methyltransferase (COMT) knockout...
  17. Effects of SLC6A4, BDNF and Ecstasy Use on Brain Structure in Young Adults
    Krista Lisdahl Medina; Fiscal Year: 2010
    ..sequelae is individual variation in baseline serotonin functioning, caused in part by polymorphisms in the serotonin transporter gene (SLC6A4), which is associated with serotonin signaling and serotonin-related diseases...
  18. Behavioral Toxicity of Chronic Alcohol Drinking in Peri-Adolescent Monkeys
    Michael A Taffe; Fiscal Year: 2012
    ..which are impaired by chronic oral alcohol intake;contributions of impulsivity, alcohol preference and serotonin transporter genotype to behavioral change;and the cognitive and behavioral effects of withdrawal from chronic alcohol ..
  19. Dysfunctional Cortico-Limbic Activity and Connectivity in Bipolar Disorder and Li
    Amit Anand; Fiscal Year: 2010
    ..to investigate the effect of genetic factors such as the high expressing and low expressing genotypes of serotonin transporter (5-HTT) promoter linked region (5-HTTLPR) polymorphism on fMRI measures of activation and connectivity...
  20. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2013
    ..Simultaneous investigation in two different populations is also expected to provide insights into potential causes undedying racial disparities in CVD risk and prevalence. ..
  21. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
    ..The ROO phase will involve examining all genes for a comprehensive evaluation of the pathways (End of Abstract) ..
  22. Jeffrey S Simons; Fiscal Year: 2015
    ..We hypothesize genotype at the serotonin transporter linked polymorphic region (5-HTTLPR) interacts with trauma exposure to predict PTSD symptoms and alcohol ..
  23. Pharmacologic Treatments in Emerging Adults
    Bankole A Johnson; Fiscal Year: 2012
    ..ondansetron treatment, and c) alcoholics who are homozygous for the long polymorphic form (LL) of the serotonin transporter (5-HTT) allele experience greater reduction in severe drinking following ondansetron treatment than those ..
  24. Francis E Lotrich; Fiscal Year: 2014
    ..Secondly, we and others have observed that promoter polymorphisms in the serotonin transporter may be associated with poor sleep quality, plausibly mediating their relationship to MDD...
  25. Alan Frazer; Fiscal Year: 2016
    ..of SSRIs to inhibit the function of what is widely considered their initial cellular target in brain- the serotonin transporter (SERT). In addition, EB but not P blocked the function of the SERT...
  26. Genes and Alterations in Brain Structure and Function in Depression
    Warren D Taylor; Fiscal Year: 2012
    ..Hypotheses: The short allele of the serotonin transporter promoter region and the catechol-O-methyltransferase val158met polymorphism will each be associated with ..
  27. Depression, Stress, Aging & Proinflammatory Cytokines
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ..study will address whether genes for two proteins involved in serotonin (5-HT) signaling, the 5-HT transporter (5-HTT) and the 5-HT1A receptor, are susceptibility genes for depression and anxiety in 192 dementia spousal caregivers ..
  28. KEVIN P CURRIE; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Serotonin (5HT) is an important neuromodulator, and the serotonin transporter (SERT) plays a central role in controlling 5HT signaling and availability...
  29. Alan Frazer; Fiscal Year: 2014
    ..SSRIs) to alter the function of what is widely considered their initial cellular target in brain - the serotonin transporter (SERT)...
  30. Claudia Schmauss; Fiscal Year: 2014
    ..Positive results from these studies could identify a new biomarker capable of predicting antidepressant treatment response. ..
  31. Development of Novel Agents for CNS-related Diseases
    Seth Y Ablordeppey; Fiscal Year: 2012
    ..on novel antidepressants using a newly identified agent SYA031 with specific binding affinity for the serotonin transporter (SERT) and 5HT1A as a lead...
  32. Chadi A Calarge; Fiscal Year: 2014
    ..For example, preclinical experiments have shown that bone cells express the serotonin transporter and a variety of functional serotonin receptors whose activity modulates bone turnover...
  33. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    ..SSRIs are thought to exert therapeutic effects by inhibiting the serotonin reuptake transporter (SERT), thereby increasing serotonin signaling, leading to our central hypothesis that genetic dissection of SSRIs-..
  34. Postnatal SSRI treatment: effects on serotonergic projections and gene expression
    Neil Allen Gray; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The serotonin transporter is the principal target of most commonly prescribed antidepressants...
  35. DAVID JOHN LAPINSKY; Fiscal Year: 2014
    ..depression and other mental illnesses, to map their corresponding binding sites and poses within the serotonin transporter (SERT)...
  36. The effects of methamphetamine self-administration on hippocampal serotonergic sy
    Lisa McFadden; Fiscal Year: 2013
    ..2010);and 3) abnormalities in the serotonin transporter (SERT;Caspi et al, 2003)...
  37. Clinical Implications of Serotonin in Bone
    Elizabeth M Haney; Fiscal Year: 2010
    ..Thus the serotonin transporter provides a potential link between osteoporosis and depression and anti-depressant treatment...
  38. Jay A Gingrich; Fiscal Year: 2016
    The serotonin transporter (SERT) is a critical regulator of emotional function that acts both during brain development as a growth modulator and as a neurotransmitter in the more mature brain...
  39. ALCOHOL PHARMACOGENETICS IN MEXICAN AMERICANS
    YU JUI WAN; Fiscal Year: 2009
    ..cytochrome P4502E1) alleles;(3) association of ADH3*2, ADH2*1, DRD2 (dopamine receptor -141C Del/Ins) and serotonin transporter gene-linked polymorphic region (5-HTTLPR) with alcoholism;(4) a strong association of ADH3*2 and ADH2*1 ..
  40. Psychosocial/Behavioral Intervention in Post-Stroke Depression (PSD)
    Pamela H Mitchell; Fiscal Year: 2013
    ..in ischemic stroke survivors for up to two years and that carrying one or more 5-HTTLPR s-alleles, a serotonin transporter gene polymorphism, was associated not only with a greater risk of PSD, but also with the greatest ..
  41. REGULATION OF SEROTONIN TRANSPORTERS
    Randy D Blakely; Fiscal Year: 2010
    ..Endogenous mechanisms that modulate SERT activity are emerging, but as yet remain ill defined...
  42. Jay Hirsh; Fiscal Year: 2016
    The human serotonin transporter protein SERT is the primary target for antidepressants used by a significant fraction of the population and also is a direct target for several drugs of abuse, yet modes of action are still unclear...
  43. Andrew C Chen; Fiscal Year: 2014
    ..The objectives of the proposed study are to determine whether genetic variants in the genes encoding the serotonin transporter (5-HTTLPR), mu-opioid receptor (OPRM1), and GABA-A receptor subunit (GABRA2) are associated with the ..
  44. Interaction of Genes, Stress, and Cognitions in the Development of Alcoholism
    KELLY CORINNE YOUNG-WOLFF; Fiscal Year: 2011
    ..Measured genotypes will be used to test whether SLEs interact with variations in the serotonin transporter variant to increase risk for alcoholism in adults...
  45. Developmental Origins of Affective Disorders
    MARK SASCHA ANSORGE; Fiscal Year: 2012
    ..lines of evidence suggest that commonly occurring functional polymorphisms in the promoter region of the serotonin transporter gene (5htt) are associated with increased susceptibility to neuropsychiatric disorders such as neuroticism,..
  46. Nathan A Kimbrel; Fiscal Year: 2016
    ..procedures (including haplotype analyses) to examine the effects of two promising candidate genes-the serotonin transporter gene (SLC6A4) and the brain-derived neurotrophic factor (BDNF) gene on PTSD...
  47. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..how early maltreatment interacts with the monoamine oxidase A genotype to yield antisocial behavior and how the 5-HTT transporter interacts with adverse early adult events to increase risk of depression, our understanding of how ..
  48. Epigenetic Regulation of Serotonin:Relevance to HIV and Methamphetamine Abuse
    GREGORY MICHAEL MILLER; Fiscal Year: 2012
    ..polymorphic variations in genes that encode the key modulators of the serotonin system, including the serotonin transporter (5-HTT), monoamine oxidase A (MAOA) and tryptophan hydroxylase 2 (TPH2) have been well-documented, ..
  49. CYNTHIA LOUISE BETHEA; Fiscal Year: 2014
    ..In addition, the regulation of serotonin-related genes TPH2, SERT, 5HT1A, MAO-A and MAO-B will be determined with in situ hybridization...
  50. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..the relevance of our structural and functional findings in bacterial transporters to understanding the function of SERT and DAT...
  51. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly H Koller; Fiscal Year: 2010
    ..Following vesicular release, the action of 5-HT is terminated by its removal from the synapse by the serotonin transporter (5-HTT, SERT, SLC6A4)...
  52. Creation of Eating/Activity Environments by New Mothers
    Deborah Young Hyman; Fiscal Year: 2010
    ..As an exploratory aim we will investigate gene (G-protein ss3 subunit C825 T and serotonin transporter 5-HTTLPR polymorphisms obtained via buccal swabs) by environment associations between postpartum weight, ..
  53. Serotonergic Immunomodulation in Neuroinflammatory Disease
    CATHERINE ELIZABETH HAGAN; Fiscal Year: 2012
    ..voltammetry will be used to study whether stimulating cerebral innate immunity in vivo alters neuronal serotonin transporter kinetics...
  54. MICHAEL L CAMILLERI; Fiscal Year: 2015
    ..expression in colorectal mucosa of SLC6A4 (the solute carrier protein that controls serotonin [5-HT] re-uptake, or SERT), p11 (another solute carrier, which modifies function of 5-HT receptor subtypes) and 12 genes involved in ..
  55. Stephanie W Watts; Fiscal Year: 2015
    ..Sprague-Dawley rats will be the primary model, but we will also use the novel serotonin transporter (SERT) knockout rat...
  56. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..5-HT is charged at physiological pH and must be removed by transport across cellular membranes using the serotonin transporter (SERT)...
  57. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..This hypothesis will be tested using male and female serotonin transporter (SERT) knockout (KO) rats, which we propose is a unique animal model of gender specific visceral ..
  58. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2012
    ..DRN) of increased tryptophan hydroxylase (TPH) serotonin-synthesizing enzyme, a decrease in the amount of serotonin transporter and 5-HT1A inhibitory autoreceptor binding and in the prefrontal cortex (PFC) of reduced 5-HT2A receptor ..
  59. Placental serotonin transporter uses ERp44 and Ero1-L for maturation.
    Fusun Kilic; Fiscal Year: 2010
    ..the embryo does not synthesis 5HT but receives it from the maternal-embryonic circulation via a specific 5HT transporter (SERT) on the membranes of the trophoblast cells...
  60. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    ..myenteric and submucosal plexuses of the small intestine (ileum and duodenum) and colon of guinea pigs and a new SERT-KO rat animal model...
  61. MAARTEN E REITH; Fiscal Year: 2016
    ..Other biogenic amine transporters are the serotonin transporter (SERT) and the norepinephrine transporter (NET), targets for many different antidepressant drugs...
  62. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ..study proposes to test interactions between genetic markers from five carefully selected regions - the serotonin transporter gene (SLC6A4), the monoamine oxidase A gene (MAOA), the catechol-O-methyltransferase gene (COMT), the type ..
  63. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  64. Pharmacogenetics, Emotional Reactivity & Smoking
    Paul Cinciripini; Fiscal Year: 2009
    ..We will also characterize other potential markers for neurotransmitter function (DRD4, DAT, SERT, NET) in terms of differences in both baseline emotional reactivity, and response to pharmacotherapy vs: the ..
  65. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly Koller; Fiscal Year: 2009
    ..Following vesicular release, the action of 5-HT is terminated by its removal from the synapse by the serotonin transporter (5-HTT, SERT, SLC6A4)...
  66. Postnatal Antidepressant Effects on Periadolescent SERT Function by Voltammetry
    Anne Milasincic Andrews; Fiscal Year: 2010
    ..Here, we will extend our studies on the use of voltammetry methods to investigate the role of the serotonin transporter (SERT) in anxiety and depression to include this important model of postnatal inhibition of serotonin ..
  67. Monoamine Transporter Structure-Function Studies
    CHRISTOPHER SURRATT; Fiscal Year: 2007
    ..The serotonin transporter protein (SERT) also plays a key role in the mood-altering effects of these drugs, especially in the case ..
  68. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..applicant): Considerable evidence accrued over the last two decades have convincingly implicated decreased serotonin transporter (SERT) binding in the pathophysiology of major depression and suicide...
  69. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2004
    Considerable evidence accrued over the last two decades have convincingly implicated decreased serotonin transporter (SERT) binding in the pathophysiology of major depression and suicide...
  70. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..HD is a fatal, genetic disorder caused by mutations in HTT, which encodes huntingtin (HTT), and affects approximately 30,000 people in the United States alone...
  71. RNAi therapy for Huntingtons disease: safety & efficacy in the nonhuman primate
    Jodi L McBride; Fiscal Year: 2010
    ..fatal, neurodegenerative disorder resulting from an expanded tri-nucleotide repeat (CAG) in exon 1 of the HD gene (HTT)...
  72. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..study the functional consequences and mechanisms underlying antidepressant-induced down-regulation of the serotonin transporter (SERT) and norepinephrine transporter (NET)...
  73. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul J Muchowski; Fiscal Year: 2012
    ..is a fatal neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the protein huntingtin (htt)...
  74. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Rare, functional gene variants that lead to hyperfunction of the serotonin transporter (SERT) have been associated with a specific subset of autism spectrum traits, rigid-compulsive behaviors ..
  75. Genetic comorbidity for disordered eating, alcohol use, and personality
    MELISSA ANNE MUNN; Fiscal Year: 2010
    ..certain personality traits, as well as vulnerability to alcohol use disorder and eating pathology, is the serotonin transporter gene (SLC6A4)...
  76. Mechanism of Fast Axonal Transport Inhibition by PolyQ-Expanded Huntingtin
    Sarah Pollema; Fiscal Year: 2009
    ..gene disease displays dominant inheritance, and is thought to involve a toxic gain of function in the Huntingtin (Htt) protein...