SERCA2

Summary

Gene Symbol: SERCA2
Description: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Alias: ATP2B, DAR, SERCA2, sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATPase Ca++ transporting cardiac muscle slow twitch 2, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2, SR Ca(2+)-ATPase 2, calcium pump 2, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, cardiac Ca2+ ATPase, endoplasmic reticulum class 1/2 Ca(2+) ATPase
Species: human

Top Publications

  1. pmc Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA
    Mol Biol Cell 17:4446-58. 2006
  2. pmc The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival
    Elizabeth Vafiadaki
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Greece
    Mol Biol Cell 20:306-18. 2009
  3. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
  4. pmc Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1
    Olivier Dellis
    Institut National de la Sante et de la Recherche Medicale, Inserm UMR S 940, Institut Universitaire d Hematologie, Universite Paris VII, Service d Anatomie et Cytologie Pathologiques, Hopital Lariboisiere, 16, Rue de la Grange aux Belles, 75010 Paris, France
    Mol Cancer 8:59. 2009
  5. ncbi Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses
    Leonard Dode
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Biol Chem 278:47877-89. 2003
  6. ncbi The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors
    Laura L Wootton
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 281:6970-6. 2006
  7. pmc The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels
    Taj D King
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1009, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Exp Cell Res 312:3693-700. 2006
  8. ncbi Modulation of endoplasmic reticulum calcium pump by Bcl-2
    T H Kuo
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 17:1903-10. 1998
  9. ncbi Spectrum of novel ATP2A2 mutations in patients with Darier's disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:1611-9. 1999
  10. pmc Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
    - del MonteF
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Circulation 100:2308-11. 1999

Research Grants

  1. Wafaie W Fawzi; Fiscal Year: 2014
  2. Malaria in Pregnancy: Nutrition and Immunologic Effects
    Wafaie W Fawzi; Fiscal Year: 2013
  3. Nitric Oxide and Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
  4. William W Latimer; Fiscal Year: 2014
  5. HIV, Risk Behaviors, and Stigma in High Risk Tanzanian Men
    Michael W Ross; Fiscal Year: 2011
  6. Urban malaria mapping: a new methodology to assess spatio-temporal trends
    MARCIA CALDAS DE CASTRO; Fiscal Year: 2012
  7. Teh Wei Hu; Fiscal Year: 2016
  8. Wafaie W Fawzi; Fiscal Year: 2016
  9. Effects of protein-calorie supplementation on HIV disease in breastfeeding women
    C Fordham von Reyn; Fiscal Year: 2013
  10. RICHARD DENNIS WADDELL; Fiscal Year: 2015

Detail Information

Publications288 found, 100 shown here

  1. pmc Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA
    Mol Biol Cell 17:4446-58. 2006
    ..Similar up-regulation of TRPC1 was also detected in epidermal layers of SERCA2+/- mice. HaCaT cells expressed TRPC1 in the plasma membrane...
  2. pmc The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival
    Elizabeth Vafiadaki
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Greece
    Mol Biol Cell 20:306-18. 2009
    ..In the current study, we determined that HAX-1 can also bind to SERCA2. Deletion mapping analysis demonstrated that amino acid residues 575-594 of SERCA2's nucleotide binding domain are ..
  3. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
    ..In addition, a novel variant of SERCA2 was significantly decreased in DM1 patients...
  4. pmc Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1
    Olivier Dellis
    Institut National de la Sante et de la Recherche Medicale, Inserm UMR S 940, Institut Universitaire d Hematologie, Universite Paris VII, Service d Anatomie et Cytologie Pathologiques, Hopital Lariboisiere, 16, Rue de la Grange aux Belles, 75010 Paris, France
    Mol Cancer 8:59. 2009
    ....
  5. ncbi Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses
    Leonard Dode
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Biol Chem 278:47877-89. 2003
    ..partial reactions of the Ca2+ transport cycle mediated by the human sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) isoforms, SERCA2a and SERCA2b, and 10 Darier disease (DD) mutants upon heterologous expression in HEK-293 cells...
  6. ncbi The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors
    Laura L Wootton
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 281:6970-6. 2006
    ....
  7. pmc The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels
    Taj D King
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1009, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Exp Cell Res 312:3693-700. 2006
    ..GSK3 activity is known to affect sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) levels...
  8. ncbi Modulation of endoplasmic reticulum calcium pump by Bcl-2
    T H Kuo
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Oncogene 17:1903-10. 1998
    ..The steady state levels of SERCA2 mRNA and protein were both increased in Bcl-2 expression clones...
  9. ncbi Spectrum of novel ATP2A2 mutations in patients with Darier's disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Hum Mol Genet 8:1611-9. 1999
    ..These results illustrate the considerable diversity of ATP2A2 mutations causing DD and suggest that additional factors are important contributors to the clinical phenotype...
  10. pmc Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
    - del MonteF
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Circulation 100:2308-11. 1999
    ..Failing human myocardium is characterized by abnormal relaxation, a deficient sarcoplasmic reticulum (SR) Ca(2+) uptake, and a negative frequency response, which have all been related to a deficiency in the SR Ca(2+) ATPase (SERCA2a) pump...
  11. ncbi S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
    Takeshi Adachi
    Vascular and Myocardial Biology Units, Whitaker Cardiovascular Institute, Boston University Medical Center, X707, 650 Albany Street, Boston, Massachusetts 02118 2393, USA
    Nat Med 10:1200-7. 2004
    ..Thus, irreversible oxidation of key thiol(s) in disease impairs NO-induced relaxation by preventing reversible S-glutathiolation and activation of SERCA by NO/ONOO(-)...
  12. pmc Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
    Katharina Mahn
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 106:10775-80. 2009
    ..Compared with control cells from healthy subjects, SERCA2 mRNA and protein expression was reduced in ASM cells from subjects with moderately severe asthma...
  13. ncbi Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease
    A Sakuntabhai
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 21:271-7. 1999
    ..mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2(+)-ATPase type 2 isoform (SERCA2) and is highly expressed in keratinocytes...
  14. ncbi Identification of a new SERCA2 splice variant regulated during monocytic differentiation
    Pascal Gelebart
    U 348 INSERM, IFR 6, Hopital Lariboisiere, 8, rue Guy Patin, 75010 Paris, France
    Biochem Biophys Res Commun 303:676-84. 2003
    ..We report that in addition to the ubiquitously expressed SERCA2b isoform, a new splice variant of SERCA2 can be detected (SERCA2c) that arises from the inclusion of a short intronic sequence located between exons 20 and ..
  15. ncbi Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+-ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP
    M Asahi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 275:15034-8. 2000
    ....
  16. pmc Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform
    Y Amrani
    INSERM U 425, , Illkirch, France
    Br J Pharmacol 115:1204-10. 1995
    ..4. Comparative western blotting of human TSMC membranes using anti-SERCA2 isoform-specific antibodies clearly showed the greater expression of the 100-kDa SERCA2-b isoform compared with ..
  17. ncbi Association between carriage of oral yeasts, malnutrition and HIV-1 infection among Tanzanian children aged 18 months to 5 years
    F Scheutz
    Department of Oral Epidemiology and Public Health, Faculty of Health Sciences, Aarhus University, Denmark
    Community Dent Oral Epidemiol 25:193-8. 1997
    ..The study was carried out in Dar-es-Salaam, Tanzania, in two maternal and child health (MCH) clinics that offer routine medical checkups to all ..
  18. ncbi Dental caries in relation to diet, saliva and cariogenic microorganisms in Tanzanians of selected age groups
    M C Mazengo
    Faculty of Dentistry, University of Kuopio, Finland
    Community Dent Oral Epidemiol 24:169-74. 1996
    ..A random sample of 12-, 35-44- and 65- to 74- year olds was drawn from Msongola (rural) and Ukombozi (urban), Dar-es-Salaam. The mean of two 24-h recalls was used for the assessment of food intake...
  19. ncbi Headache in a nonclinical population in Dar es Salaam, Tanzania. A community-based study
    W B Matuja
    Neurology Clinic, Muhimbili University College of Health Sciences, University of Dar es Salaam, Tanzania
    Headache 35:273-6. 1995
    ..3 lost work days per year in comparison to a control group of 154 persons with an average of 5.7 lost work days per year for reasons other than headache (X2 P = 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. doi Darier disease, multiple bone cysts, and aniridia due to double de novo heterozygous mutations in ATP2A2 and PAX6
    Marco Castori
    Experimental Medicine Department, Sapienza University of Rome, San Camillo Forlanini Hospital, Italy
    Am J Med Genet A 149:1768-72. 2009
    ..This finding suggests a role for ATP2A2 in bone biology. More systematic studies are expected in order to estimate the true prevalence of bone cysts in DD and the relationship between skeletal changes and ATP2A2 perturbation...
  21. pmc Current clinical efficacy of chloroquine for the treatment of Plasmodium falciparum infections in urban Dar es Salaam, United Republic of Tanzania
    Z Premji
    Department of Parasitology Medical Entomology, Muhimbili University College of Health Sciences, Dar es Salaam, United Republic of Tanzania
    Bull World Health Organ 77:740-4. 1999
    ..the efficacy of chloroquine in the treatment of uncomplicated malaria in young children (n = 200) in urban Dar es Salaam. Chloroquine failure was found in 43% of the children. Of these, 12...
  22. doi No indications for HPV involvement in the hypertrophic skin lesions of a Darier disease case without ATP2A2 gene mutations
    Cinzia Borgogna
    Department of Clinical and Experimental Medicine, Medical School of Novara, University of Piemonte Orientale Amedeo Avogadro, Novara, Italy
    J Cutan Pathol 36:1005-9. 2009
    ..Haploinsufficiency of the ATP2A2 gene product, sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2), is the underlying cause of most cases...
  23. ncbi Anti-diabetic drugs in the private and public sector in Dar es Salaam, Tanzania
    M Justin-Temu
    Department of Pharmaceutics, School of Pharmacy, Muhimbili University of Health and Allied Sciences, P O Box 65013, Dares Salaam, Tanzania
    East Afr Med J 86:110-4. 2009
    To compare availability, cost, affordability and sources of anti-diabetic drugs between private and public health facilities in Dar es Salaam, Tanzania.
  24. doi A novel splice-site mutation of ATP2A2 gene in a Chinese family with Darier disease
    Jia Huo
    Department of Dermatology, The Second Hospital of Xi an Jiaotong University, 157 Xi Wu Road, Xi an, 710004 Shaanxi, People s Republic of China
    Arch Dermatol Res 302:769-72. 2010
    ..of DD are defects in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+) ATPase isoform 2 (SERCA2)...
  25. ncbi Assessment of sarcoplasmic reticulum Ca(2+) flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction
    Paul Neary
    Department of Medical Cardiology, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Pflugers Arch 444:360-71. 2002
    ..SR Ca(2+) flux rates associated with sarco-endoplasmic reticulum Ca(2+) ATPase type 2 (SERCA2)-mediated uptake, ryanodine receptor type 2 (RyR2)-mediated Ca(2+) efflux and background SR Ca(2+) leak were ..
  26. ncbi Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump
    L H Liu
    Departments of Molecular Genetics, Biochemistry and Microbiology and Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 276:26737-40. 2001
    Mutations in the human ATP2A2 gene, encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), cause Darier disease, an autosomal dominant skin disease characterized by multiple keratotic papules in the seborrheic regions of ..
  27. ncbi Darier disease: a guide to the physician
    Aleksandar Godic
    Department of Dermatovenereology, University Clinical Centre, Ljubljana, Slovenia
    J Med 35:5-17. 2004
    ..It is caused by mutations of ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2+ ATPase isoform 2 (SERCA2 protein)...
  28. doi Clinical and mutational heterogeneity of Darier disease in Tunisian families
    Mbarka Bchetnia
    Molecular Investigation of Genetic Orphan Diseases Research Unit and Department of Pathology, Institut Pasteur de Tunis, Tunis, Tunisia
    Arch Dermatol 145:654-6. 2009
    ..To study the mutation spectrum and phenotype-genotype correlation of Darier disease (DD) in Tunisian patients...
  29. pmc Cardiac hypertrophy and thyroid hormone signaling
    Wolfgang Dillmann
    University of California, San Diego, USA
    Heart Fail Rev 15:125-32. 2010
    ..with thyroid hormone promoting expression of the gene encoding the calcium pump of the sarcoplasmic reticulum (SERCa2). In contrast, in hypothyroid animals phospholamban levels, which inhibit the SERCa2 pump, are increased...
  30. doi New mutations of Darier disease in Tunisian patients
    Mbarka Bchetnia
    Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut Pasteur de Tunis, Pasteur, 1002 Tunis Belvedere, Tunisia
    Arch Dermatol Res 301:615-9. 2009
    ..Both pathogenic mutations are located in exon 13 of the ATP2A2 gene and affected the ATP-binding site of the SERCA2 protein...
  31. ncbi A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study
    A O Jorgensen
    Department of Anatomy, University of Toronto, Ontario, Canada
    Cell Motil Cytoskeleton 9:164-74. 1988
    ....
  32. ncbi Evaluation of the quality of amodiaquine and sulphadoxine/pyrimethamine tablets sold by private wholesale pharmacies in Dar Es Salaam Tanzania
    O M S Minzi
    Clinical Pharmacology Department, Faculty of Medicine, Muhimbili University College of Health Sciences MUCHS, Dar es Salaam, Tanzania
    J Clin Pharm Ther 28:117-22. 2003
    ..The aim of this work was to assess the quality of SP and AQ tablets marketed by wholesale pharmacies in Dar Es Salaam, Tanzania.
  33. ncbi Consequences of depleted SERCA2-gated calcium stores in the skin
    Eliane J Muller
    Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Bern, Switzerland
    J Invest Dermatol 126:721-31. 2006
    Sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) pumps belong to the family of Ca2+-ATPases responsible for the maintenance of calcium in the endoplasmic reticulum...
  34. ncbi Food cravings, aversions and pica among pregnant women in Dar es Salaam, Tanzania
    C N M Nyaruhucha
    Sokoine University of Agriculture, Department of Food Science and Technology, P O Box 3006, Morogoro, Tanzania
    Tanzan J Health Res 11:29-34. 2009
    ..aversions and pica during pregnancy among 204 pregnant and lactating women attending two health facilities in Dar es Salaam City, Tanzania. Nausea and vomiting were reported by 82.8% of all women of which 43...
  35. ncbi Nature of gram-negative rod antibiotic resistance during antibiotic rotation
    Heather L Evans
    Surgical Infectious Disease Research Laboratory, Department of Surgery, UVA Health System, Charlottesville, VA 22908 1380, USA
    Surg Infect (Larchmt) 6:223-31. 2005
    ..The aim of this study was to characterize the evolution of gram-negative antibiotic resistance during a study of empiric antibiotic rotation...
  36. pmc Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication
    Peter Friebe
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 1 Barker Hall, Berkeley, CA 94720 7354, USA
    J Virol 84:6103-18. 2010
    ..This new sequence is located downstream of the AUG, designated the 5' downstream AUG region (5' DAR); the motif predicted to be complementary in the 3' end is termed the 3' DAR...
  37. pmc A new tent trap for sampling exophagic and endophagic members of the Anopheles gambiae complex
    Nicodemus J Govella
    Ifakara Health Institute, Coordination Office, Dar es Salaam, United Republic of Tanzania
    Malar J 8:157. 2009
    Mosquito sampling methods are essential for monitoring and evaluating malaria vector control interventions. In urban Dar es Salaam, human landing catch (HLC) is the only method sufficiently sensitive for monitoring malaria-transmitting ..
  38. doi Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study
    Charles Kilewo
    Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 52:406-16. 2009
    ..The main aim of this study was to reduce breast-milk transmission of HIV-1 by treating HIV-1-infected women with highly active antiretroviral therapy (HAART) during breastfeeding...
  39. pmc Optimal blood mononuclear cell isolation procedures for gamma interferon enzyme-linked immunospot testing of healthy Swedish and Tanzanian subjects
    C Nilsson
    Dept of Immunology and Vaccinology, Swedish Institute for Infectious Disease Control and Karolinska Institute, 171 82 Solna, Sweden
    Clin Vaccine Immunol 15:585-9. 2008
    ..to find the cell preparation technique best suited for two clinical vaccine trial sites: Stockholm, Sweden, and Dar es Salaam, Tanzania...
  40. ncbi Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system
    D J Thuerauf
    Heart Institute and the Department of Biology, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 276:48309-17. 2001
    ..the hypothesis that ATF6 serves as a regulator of the expression of sarco/endoplasmic reticulum calcium ATPase-2 (SERCA2), a protein that transports calcium into the SR from the cytoplasm...
  41. pmc Community response to artemisinin-based combination therapy for childhood malaria: a case study from Dar es Salaam, Tanzania
    Vinay R Kamat
    Department of Anthropology, University of British Columbia, Vancouver, Canada
    Malar J 9:61. 2010
    ..The paper specifically examines the perceived efficacy of ALu as articulated by the mothers of young children diagnosed with malaria and prescribed ALu...
  42. ncbi The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling
    Wen Zhao
    Department of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Circulation 113:995-1004. 2006
    Phospholamban (PLN) is an inhibitor of the Ca2+ affinity of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2)...
  43. ncbi Adolescent girls with illegally induced abortion in Dar es Salaam: the discrepancy between sexual behaviour and lack of access to contraception
    V Rasch
    Department of Obstetrics and Gynaecology, Odense University Hospital, DK 5000 Odense C, Denmark
    Reprod Health Matters 8:52-62. 2000
    This article reports on a study of induced abortion among adolescent girls in Dar es Salaam, Tanzania, who were admitted to a district hospital in Dar es Salaam because of an illegally induced abortion in 1997...
  44. ncbi Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor
    Yoon Namkung
    Molecular Neuropharmacology Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
    J Biol Chem 279:49533-41. 2004
    ..protein kinase A (PKA) and protein kinase C (PKC), to mediate phosphorylation and desensitization of the D2 DAR. HEK293T cells were transiently transfected with the D2 DAR and then treated with intracellular activators and ..
  45. ncbi Late postnatal transmission of human immunodeficiency virus type 1 infection from mothers to infants in Dar es Salaam, Tanzania
    K Karlsson
    Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm
    Pediatr Infect Dis J 16:963-7. 1997
    To study late postnatal transmission of human immunodeficiency virus type 1 in a cohort of children born to HIV-1-seropositive mothers who delivered at Muhimbili Medical Centre in Dar es Salaam, Tanzania.
  46. ncbi Influences of increased expression of the Ca2+ ATPase of the sarcoplasmic reticulum by a transgenic approach on cardiac contractility
    W H Dillmann
    Department of Medicine, University of California, San Diego 92093 0618, USA
    Ann N Y Acad Sci 853:43-8. 1998
    ..The Ca2+ ATPase of the sarcoplasmic reticulum (SERCA2) contributes in an important manner to diastolic Ca2+ lowering and relaxation of the heart...
  47. ncbi Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine
    W Lewis
    Department of Pathology, University of Cincinnati College of Medicine, Ohio, USA
    Lab Invest 80:187-97. 2000
    ..echocardiographic studies were performed and abundance of mRNA for cardiac sarcoplasmic reticulum calcium ATPase (SERCA2), sodium calcium exchanger (NCX1), and atrial natriuretic factor were determined individually using Northern ..
  48. ncbi Autoreceptor mechanism regulating carotid body dopamine release from adult and 10-day-old rabbits
    A Bairam
    Unité de Recherche en Périnatologie, Centre Hospitalier Universitaire de Quebec, PQ, Canada
    Respir Physiol 120:27-34. 2000
    ..We tested the hypothesis that CB DAr is autoregulated in a concentration and age dependent manner. Using an in vitro CB infusion model [Bairam, A...
  49. ncbi [Effects of valsartan on sarcoplasmic reticulum calcium adenosine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]
    Fu Zheng Qu
    Department of Cardiology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
    Zhonghua Xin Xue Guan Bing Za Zhi 36:790-3. 2008
    To investigate the effects of valsartan on expressions of myocardial sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2), protein kinase A (PKA) and protein phosphatase 1 alpha (PP1alpha) in a rabbit model of heart failure.
  50. pmc Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania
    Eligius F Lyamuya
    Department of Microbiology and Immunology, Muhimbilli University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Infect Dis 9:19. 2009
    ....
  51. ncbi Localization of intracellular Ca2+ stores in HeLa cells during infection with Chlamydia trachomatis
    M Majeed
    Divisions of Medical Microbiology and Clinical Microbiology, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    J Cell Sci 112:35-44. 1999
    ..type-1 inositol-1,4, 5-trisphosphate receptor (IP3-R), and Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase type 2 (SERCA2) in HeLa cells infected with C. trachomatis serovar L2...
  52. doi Defining how aging Pseudotsuga and Abies compensate for multiple stresses through multi-criteria assessment of a functional-structural model
    Maureen C Kennedy
    University of Washington, Quantitative Ecology and Resource Management, Seattle, WA 98195 2100, USA
    Tree Physiol 30:3-22. 2010
    ..The model for branch development that we use simulates the process of delayed adaptive reiteration (DAR), whereby new foliage grows from suppressed buds within the established branch structure...
  53. ncbi Dropouts in a long-term follow-up study involving voluntary counseling and HIV testing: experience from a cohort of police officers in Dar Es Salaam, Tanzania
    F Mugusi
    Muhimbili Medical Centre, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 30:119-23. 2002
    ..In studies with long-term follow-up, reasons for nonresponse may provide invaluable information that may be gathered through continued contact with study subjects who have withdrawn from the study...
  54. doi Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy
    Joanna E Kontaraki
    Molecular Cardiology Laboratory, School of Medicine, University of Crete, Crete, Greece
    Eur J Heart Fail 12:541-8. 2010
    ..To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function...
  55. ncbi HIV/AIDS and injection drug use in the neighborhoods of Dar es Salaam, Tanzania
    Sheryl A McCurdy
    University of Texas Health Science Center at Houston, School of Public Health, WHO Center for Health Promotion and Prevention Research, Houston, TX 77030, USA
    Drug Alcohol Depend 82:S23-7. 2006
    ..practices and HIV recovered from used syringes collected from 73 heroin injection drug users (IDUs) in Dar es Salaam, Tanzania, between October 2003 and January 2004...
  56. ncbi Urinary schistosomiasis in schoolchildren in Dar-es-Salaam, Tanzania, and the factors influencing its transmission
    R Ndyomugyenyi
    Ministry of Health, Vector Borne Diseases, P O Box 1661, Kampala, Uganda
    Ann Trop Med Parasitol 95:697-706. 2001
    ..urinary schistosomiasis among the schoolchildren living in Kigogo administrative ward of the Kinondoni district of Dar-es-Salaam city, Tanzania, and the factors influencing the transmission of the causative agent, Schistosoma ..
  57. doi Prevention of mother-to-child transmission of HIV-1 through breast-feeding by treating infants prophylactically with lamivudine in Dar es Salaam, Tanzania: the Mitra Study
    Charles Kilewo
    Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    J Acquir Immune Defic Syndr 48:315-23. 2008
    ..To investigate the possibility of reducing mother-to-child transmission (MTCT) of HIV-1 through breast-feeding by prophylactic antiretroviral (ARV) treatment of the infant during the breast-feeding period...
  58. pmc The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners
    Manfred Wiessler
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:19-28. 2009
    ..The Diels-Alder ligation Reaction with inverse electron demand (DAR(inv)) turns out to be an appropriate candidate...
  59. ncbi Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients
    F J Giordano
    Department of Medicine, University of California at San Diego in La Jolla, USA
    Circulation 96:400-3. 1997
    Decreased expression of the sarcoplasmic reticulum (SR) Ca2+-ATPase of the cardiac myocyte (SERCA2) and abnormal Ca2+ regulation have been independently linked to human heart failure...
  60. ncbi Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription
    M Arai
    Second Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan
    Circ Res 86:8-14. 2000
    ..We have recently demonstrated that expression of mRNA encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase 2 (SERCA2), a major Ca(2+) transport protein in SR, is markedly decreased in DOX-treated hearts...
  61. ncbi Organic liquids storage tanks volatile organic compounds (VOCS) emissions dispersion and risk assessment in developing countries: the case of Dar-es-Salaam City, Tanzania
    Msafiri M Jackson
    Department of Environmental Engineering, University College of Lands and Architectural Studies, P O Box 35176, Dar es Salaam, Tanzania
    Environ Monit Assess 116:363-82. 2006
    ..emission estimation of nine volatile organic compounds (VOCs) from eight organic liquids storage tanks companies in Dar-es-Salaam City Tanzania has been done by using US EPA standard regulatory storage tanks emission model (TANKS 4.9b)...
  62. ncbi Constraints on good child-care practices and nutritional status in urban Dar-es-Salaam, Tanzania
    Kissa B M Kulwa
    Department of Food Science and Technology, Sokoine University of Agriculture, Morogoro, Tanzania
    Food Nutr Bull 27:236-44. 2006
    ..Although significant gains have been made in the fight against malnutrition in Tanzania, the nutritional status of preschool children in urban areas is not improving...
  63. pmc Mimicking a semi-arid tropical environment achieves dormancy alleviation for seeds of Australian native Goodeniaceae and Asteraceae
    G L Hoyle
    Integrated Seed Research Unit, School of Land, Crop and Food Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Ann Bot 101:701-8. 2008
    ..It was hypothesised that optimum dormancy-alleviating treatments would reflect environmental conditions that seeds experience in situ, and this premise was tested for PD seeds of four species native to south-west Qld...
  64. ncbi Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene
    M Periasamy
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 274:2556-62. 1999
    The sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene encodes both SERCA2a, the cardiac sarcoplasmic reticulum Ca2+ pump, and SERCA2b, which is expressed in all tissues...
  65. ncbi Roadside concentration of gaseous and particulate matter pollutants and risk assessment in Dar-es-Salaam, Tanzania
    Msafiri M Jackson
    Department of Environmental Engineering, University College of Lands and Architectural Studies, Dar es Salaam, Tanzania tz
    Environ Monit Assess 104:385-407. 2005
    This study used manual air sampling method to assess the contribution of road traffic to air pollution level in Dar-es-Salaam City, Tanzania. Samples were collected from 11 different sites...
  66. ncbi Heroin and HIV risk in Dar es Salaam, Tanzania: youth hangouts, mageto and injecting practices
    S A McCurdy
    University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, USA
    AIDS Care 17:S65-76. 2005
    ..during the months of February and July 2003 with 51 male and female injectors residing in 8 neighbourhoods in the Dar es Salaam, Tanzania...
  67. ncbi Urban-rural contrasts in explanatory models and treatment-seeking behaviours for stroke in Tanzania
    G Mshana
    National Institute for Medical Research, Mwanza, Tanzania
    J Biosoc Sci 40:35-52. 2008
    ..project on stroke incidence, focuses on local understandings and treatment-seeking behaviours in urban (Dar-es-Salaam) and rural (Hai) areas of Tanzania...
  68. ncbi Occlusion among a group of Tanzanian urban schoolchildren
    H Kerosuo
    Division of Dentistry, University of Dar es Salaam, Tanzania
    Community Dent Oral Epidemiol 16:306-9. 1988
    Occlusion and its variations were studied in a group of primary schoolchildren (n = 642, age 11-18 yr) in Dar es Salaam. Most children (96%) had Angle's Class I occlusion...
  69. pmc Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region
    S Monk
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 62:890-903. 1998
    ..Therefore, this detailed integrated physical, genetic, and partial transcript map provides an important resource for the isolation of the DD gene and, possibly, other disease genes...
  70. ncbi Overexpression of SERCA2 Atpase in vascular smooth muscle cells treated with oxidized low density lipoprotein
    H Massaeli
    Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, and University of Manitoba, Winnipeg, Canada
    Mol Cell Biochem 207:137-41. 2000
    ..One of the primary Ca2+ uptake mechanisms in VSMC is through the SERCA2 ATPase calcium pump in the sarcoplasmic reticulum. VSMC were chronically treated with 0.005-0...
  71. ncbi Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury
    R J Talmadge
    Muscle Function Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Appl Physiol (1985) 92:147-54. 2002
    ..Most MHC I fibers contained SERCA2. Most MHC IIa fibers contained SERCA1. All MHC IIx fibers contained SERCA1 exclusively...
  72. doi Micro-perfusion for cardiac tissue engineering: development of a bench-top system for the culture of primary cardiac cells
    Luda Khait
    Section of Cardiac Surgery, University of Michigan, MSRB I, A510E, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Ann Biomed Eng 36:713-25. 2008
    ..We evaluated the cell viability, cell adhesion, total protein, total RNA, and changes in the expression of SERCA2 and phospholamban using RT-PCR, with N = 6 for each group...
  73. ncbi Causes, magnitude and management of burns in under-fives in district hospitals in Dar es Salaam, Tanzania
    M Justin-Temu
    Dept of Pharmaceutics, School of Pharmacy, MUHAS
    East Afr J Public Health 5:38-42. 2008
    To determine the causes, magnitude and management of burns in children under five years of age who were admitted in the district hospitals of Dar es Salaam City, Tanzania.
  74. ncbi Performance and acceptability of the FluoLED Easy module for tuberculosis fluorescence microscopy
    A Van Deun
    Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium
    Int J Tuberc Lung Dis 12:1009-14. 2008
    Tuberculosis (TB) reference laboratory in Bangkok, Thailand, and two health centres in Dar es Salaam, Tanzania.
  75. doi Increased O2 consumption in excitation-contraction coupling in hypertrophied rat heart slices related to increased Na+ -Ca2+ exchange activity
    Juichiro Shimizu
    Department of Physiology II, Nara Medical University, Kashihara, 634 8521, Japan
    J Physiol Sci 59:63-74. 2009
    ..Namely, mVO(2) consumed by sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) was depressed by 40%; mVO(2) consumed by the Na(+)/K(+)-ATPase (NKA)-Na(+)/Ca(2+) exchange (NCX) coupling was ..
  76. doi Neonatal arthritis disturbs sleep and behaviour of adult rat offspring and their dams
    Suely Roizenblatt
    Department of Psychobiology, Universidade Federal de Sao Paulo UNIFESP, Brazil
    Eur J Pain 14:985-91. 2010
    ..Compared to their respective controls at PN12, dams of arthritic rats (DAR) showed a longer latency in expressing pup retrieval and dam-pup interaction...
  77. pmc Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception
    Naoko Iguchi
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23165. 2011
    ..Further studies showed that Serca2 was mainly expressed in the T1R3-expressing sweet and umami TRCs, suggesting that the loss of function of Serca3 ..
  78. pmc POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters
    Grigory Krapivinsky
    Department of Cardiology, The Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:19234-9. 2011
    ..Store depletion promotes STIM1-POST complex binding to smooth ER and plasma membrane Ca(2+) ATPases (SERCAs and PMCAs, respectively), Na/K-ATPase, as well as to the nuclear transporters, importins-β and exportins...
  79. doi Hypoxia in early pregnancy induces cardiac dysfunction in adult offspring of Rattus norvegicus, a non-hypoxia-adapted species
    David Hauton
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Comp Biochem Physiol A Mol Integr Physiol 163:278-85. 2012
    ..01 for male and female rats) but not in MH-male rats. Coronary flow was reduced (P<0.01) and SERCA2 protein expression increased (2-fold, P<0.05) in female offspring, while eNOS protein levels were increased (2...
  80. doi An urgent need to scale-up injecting drug harm reduction services in Tanzania: prevalence of blood-borne viruses among drug users in Temeke District, Dar-es-Salaam, 2011
    Anna L Bowring
    Burnet Institute, 85 Commercial Rd, Melbourne, Victoria 3004, Australia
    Int J Drug Policy 24:78-81. 2013
    ..These behaviours have implications for transmission of blood-borne viruses, including HIV and hepatitis C (HCV)...
  81. doi Pharmacokinetics difference of multiple active constituents from decoction and maceration of Fuzi Xiexin Tang after oral administration in rat by UPLC-MS/MS
    Qian Zhang
    The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China Shanghai R and D Centre for Standardization of Chinese Medicines, 199 Guoshoujing Road, Shanghai 201210, China
    J Pharm Biomed Anal 92:35-46. 2014
    ..of FXT (DFXT, 30gkg(-1)), maceration of FXT (MFXT, 30gkg(-1)) and decoction of Aconiti Lateralis Radix Preparata (DAR, 6gkg(-1)) by a validated UPLC-MS/MS method...
  82. pmc Alterations of the Ca²⁺ signaling pathway in pancreatic beta-cells isolated from db/db mice
    Kuo Liang
    Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
    Protein Cell 5:783-94. 2014
    ..the model, the activity levels of the two subtypes of the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump, SERCA2 and SERCA3, were severely down-regulated in diabetic cells to 65% and 0% of the levels in normal cells...
  83. doi RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells
    Elizabeth D Pratico
    Department of Surgery, Duke University Medical Center, Durham, North Carolina
    Stem Cells Dev 24:2622-33. 2015
    ..CMs) in vitro as judged by increased expression of cardiac troponin T, α-sarcomeric actinin, RyR2, and SERCA2 and displayed enhanced caffeine-sensitive calcium release...
  84. pmc Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2
    Xiaohong T Gan
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Am J Pathol 185:3202-10. 2015
    ..reticulum calcium-regulatory proteins particularly in hearts from male mice that had depressed levels of SERCA2 and phosphorylated phospholamban...
  85. ncbi Key considerations in scaling up male circumcision in Tanzania: views of the urban residents in Tanzania
    Joel M Francis
    National Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania
    Tanzan J Health Res 14:61-7. 2012
    ..This cross sectional survey was conducted among members of the police force in Dar es Salaam Tanzania from January 2010 to July 2010...
  86. pmc Factors leading to cesarean section delivery at Felegehiwot referral hospital, Northwest Ethiopia: a retrospective record review
    Fantu Eyowas Abebe
    Strengthening Human Resource for Health Project, INGO, P O Box, 1566, Bahir Dar, Ethiopia
    Reprod Health 13:6. 2016
    ..Appreciating the limited information in this area the current study assessed the rate and factors associated with cesarean section in Felegehiwot referral hospital, Bahir Dar, northwest Ethiopia.
  87. doi Der Einsatz der Dermatoskopie in der Diagnose und Therapie von nichtmelanozytären Hautkrebsformen
    Teresa Deinlein
    Universitätsklinik für Dermatologie und Venerologie, Medizinische Universitat Graz, Osterreich
    J Dtsch Dermatol Ges 14:144-52. 2016
    Die Dermatoskopie stellt heute einen integrativen Teil jeder klinischen Hautkrebsuntersuchung dar, da sie die Früherkennung von melanozytären und nichtmelanozytären Hautkrebsformen im Vergleich zur Untersuchung mit dem bloßen Auge ..
  88. pmc An improved mosquito electrocuting trap that safely reproduces epidemiologically relevant metrics of mosquito human-feeding behaviours as determined by human landing catch
    Nicodem J Govella
    Environmental Health and Ecological Sciences Thematic Group, Coordination Office, Ifakara Health Institute, PO Box 78373, Kiko Avenue, Mikocheni, Dar es Salaam, United Republic of Tanzania
    Malar J 15:465. 2016
    ..Here compare the performance of an improved prototype of the mosquito electrocuting grid trap (MET) as a safer alternative with HLC for measuring malaria vector behaviour in Dar es Salaam, Tanzania.
  89. doi Keratin mediated attachment of stem cells to augment cardiomyogenic lineage commitment
    Lopamudra Das Ghosh
    Department of Materials Engineering and Indian Institute of Science, Bangalore 560012 India
    Colloids Surf B Biointerfaces 151:178-188. 2016
    ....
  90. doi Mendelian Disorders of Cornification Caused by Defects in Intracellular Calcium Pumps: Mutation Update and Database for Variants in ATP2A2 and ATP2C1 Associated with Darier Disease and Hailey-Hailey Disease
    Ruud G L Nellen
    Departments of Dermatology
    Hum Mutat . 2016
    ..0), for variants reported in the literature and future inclusions. This data may be of use as a reference tool in further research on treatment of DD and HHD. This article is protected by copyright. All rights reserved...
  91. pmc Knowledge of mosquitos in relation to public and domestic control activities in the cities of Dar es Salaam and Tanga
    C Stephens
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 73:97-104. 1995
    A study of community awareness of mosquitos and related subjects in the residential areas of two Tanzanian cities (Dar es Salaam and Tanga) showed that residents were well aware of mosquitos...
  92. ncbi Distribution of the organellar Ca2+ transport ATPase SERCA2 isoforms in the cat brain
    F Baba-Aissa
    Laboratorium voor Fysiologie, KULeuven, Belgium
    Brain Res 743:141-53. 1996
    Of the three genes encoding the Ca2+ transport ATPases of the endoplasmic reticulum, the SERCA2 gene is the major isoform expressed in the mammalian brain...
  93. pmc SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis
    M Chami
    The French Institute of Health and Medical Research Institut National de la Santé et de la Recherche Médicale INSERM Pasteur U370 Necker Faculty Institute of Medicine, 75015 Paris, France
    J Cell Biol 153:1301-14. 2001
    ..These data reveal a further mechanism modulating Ca(2+) accumulation into the ER of nonmuscle cells and highlight the relevance of S1T proteins to the control of apoptosis...
  94. ncbi SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain
    Li Qing Jin
    Department of Physiology and Pharmacology, City University of New York Medical School, New York 10031, USA
    J Neurochem 85:378-86. 2003
    Previously a distinct D1-like dopamine receptor (DAR) that selectively couples to phospholipase C/phosphatidylinositol (PLC/PI) was proposed. However, lack of a selective agonist has limited efforts aimed at characterizing this receptor...
  95. ncbi Syntheses, spectroscopic characterization and thermal behavior on novel binuclear transition metal complexes of hydrazones derived from 4,6-diacetylresorcinol and oxalyldihydrazine
    Adel A A Emara
    Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11341, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 69:757-69. 2008
    4,6-Diacetylresorcinol (DAR) serves as precursor for the formation of different hydrazone ligands, which are di-, tetra- or hexa-basic with two symmetrical sets of O(2)N tridentate, O(2)N(2) tetradentate or O(4)N(2) hexadentate chelating ..
  96. ncbi Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction
    Jenny Lassmann
    The John W Duckett Center for Pediatric Urology at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 294:R58-65. 2008
    The sarco(endo)plasmic reticulum Ca(2+)-ATPase2 (SERCA2) is downregulated in cardiac hypertrophy with decompensation...
  97. doi Polycyclic aromatic hydrocarbon (PAH) contamination of surface sediments and oysters from the inter-tidal areas of Dar es Salaam, Tanzania
    Lydia Gaspare
    Department of Aquatic Environment and Conservation, University of Dar es Salaam, P O Box 60091, Dar es Salaam, Tanzania
    Environ Pollut 157:24-34. 2009
    Surface sediment and oyster samples from the inter-tidal areas of Dar es Salaam were analyzed for 23 polycyclic aromatic hydrocarbons (PAHs) including the 16 compounds prioritized by US-EPA using GC/MS...
  98. pmc Maternal and neonatal colonisation of group B streptococcus at Muhimbili National Hospital in Dar es Salaam, Tanzania: prevalence, risk factors and antimicrobial resistance
    Agricola Joachim
    Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    BMC Public Health 9:437. 2009
    ..This study was conducted in Dar es Salaam, Tanzania to determine the prevalence of GBS colonisation among pregnant women, the neonatal colonisation ..
  99. doi Enzymatic synthesis of 2'-deoxyadenosine and 6-methylpurine-2'-deoxyriboside by Escherichia coli DH5alpha overexpressing nucleoside phosphorylases from Escherichia coli BL21
    Shenghua Liang
    State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200433, PR China
    J Biosci Bioeng 110:165-8. 2010
    ..coli DH5alpha. The recombinant strains were employed to synthesize 2'-deoxyadenosine (dAR) and 6-methylpurine-2'-deoxyriboside (MePdR)...
  100. doi Analysis of recombinant human erythropoietin and darbepoietin in spiked plasma
    Ashok K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
    Proteomics Clin Appl 1:626-39. 2007
    Darbepoietin (DAR) and recombinant human erythropoietin (rhEPO) stimulate erythropoiesis, leading to an increase in red blood cells...
  101. pmc Anemia in adults with tuberculosis is associated with HIV and anthropometric status in Dar es Salaam, Tanzania
    E Saathoff
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 15:925-32. 2011
    Tuberculosis (TB) infected adults attending out-patient TB clinics in Dar es Salaam, Tanzania.

Research Grants68

  1. Wafaie W Fawzi; Fiscal Year: 2014
    ..between the Harvard School of Public Health in Boston, and Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania...
  2. Malaria in Pregnancy: Nutrition and Immunologic Effects
    Wafaie W Fawzi; Fiscal Year: 2013
    ..out by Harvard School of Public Health in collaboration with Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania...
  3. Nitric Oxide and Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..Aim 1 studies will be done with children at the Hubert Kairuki Memorial University (HKMU) in Dar es Salaam, Tanzania;Aim 2 studies will be done with adults at the Queen Elizabeth Hospital in Sabah, Malaysian ..
  4. William W Latimer; Fiscal Year: 2014
    ..In Dar es Salaam, Tanzania, recent studies suggest that the estimated prevalence of 12,000 injection drug users is rapidly ..
  5. HIV, Risk Behaviors, and Stigma in High Risk Tanzanian Men
    Michael W Ross; Fiscal Year: 2011
    ..We propose a mixed methods study (qualitative, quantitative, and biological STI/HIV markers) to study 350 MSM in Dar es Salaam (high HIV prevalence) and Tanga (lower prevalence), Tanzania, where there are no available data on MSM...
  6. Urban malaria mapping: a new methodology to assess spatio-temporal trends
    MARCIA CALDAS DE CASTRO; Fiscal Year: 2012
    ..the proposed methodological approach using data collected during the Urban Malaria Control Program (UMCP) in Dar es Salaam, Tanzania...
  7. Teh Wei Hu; Fiscal Year: 2016
    ..Through professional contact, our research team was approached by the University of Dar-es-Salaam in Tanzania to extend our research experiences and capacity building from China to Tanzania: the demand ..
  8. Wafaie W Fawzi; Fiscal Year: 2016
    ..and Development for Health (MDH) President's Emergency Plan for AIDS Relief (PEPFAR) treatment program in Dar-es-Salaam, Tanzania...
  9. Effects of protein-calorie supplementation on HIV disease in breastfeeding women
    C Fordham von Reyn; Fiscal Year: 2013
    ..of Health and Allied Sciences in Tanzania we will conduct 3 nutritional studies among HIV-infected women in Dar es Salaam...
  10. RICHARD DENNIS WADDELL; Fiscal Year: 2015
    ..short residency training at DC for MUHAS staff in the new OSP, (b) short-term "continuing education" programs in Dar for these individuals (and others) after they return to Tanzania, (c) local training for administrators of smaller ..
  11. Suzanne Maman; Fiscal Year: 2016
    ..The proposed study applies innovative, multilevel intervention methods to engage social networks of young men in Dar es Saalam, Tanzania to reduce HIV risk and the perpetration of gender-based violence...
  12. MARTA I MULAWA; Fiscal Year: 2015
    ..an intervention with high-risk networks of young men who socialize in stable social clubs called "camps" in Dar es Salaam, Tanzania...
  13. Tanzania AIDS and TB ICOHRTA
    FERDINAND MUKAMA MUGUSI; Fiscal Year: 2013
    ..Training will be provided in Boston and Dar es Salaam, with the latter assuming greater proportion of the training activities over the five years of the ..
  14. Norma C Ware; Fiscal Year: 2014
    ..University, Cambridge, MA, USA;Jos University, Jos, Nigeria;and Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania...
  15. Elizabeth Costenbader; Fiscal Year: 2015
    ..sampling may not be justified, and propose to compare three different sampling approaches in two different areas (Dar es Salaam, Tanzania and Atlanta, GA) to determine if different sampling approaches produce similar network ..
  16. Claudia A Hawkins; Fiscal Year: 2016
    ..aims to assess liver fibrosis in HIV/HBV co-infected as well as HIV and HBV mono- infected individuals in Dar es Salaam, Tanzania...
  17. Tanzanian Drug Treatment as AIDS Prevention - Reliability and Validity Study
    Mark L Williams; Fiscal Year: 2010
    ..is to conduct formative research necessary to the implement of drug treatment as an HIV prevention intervention in Dar es Salaam, Tanzania...
  18. Harvard Tanzania HIV/AIDS Clinical Trials Unit
    Wafaie W Fawzi; Fiscal Year: 2013
    ..partners at two Clinical Research Sites (CRS), namely Muhimbili University College of Health Sciences (MUCHS) in Dar es Salaam and Kilimanjaro Christian Medical Center (KCMC) in Moshi...
  19. African Organization for Reseach and Training in Cancer (AORTIC) Seventh Internat
    Sulma Mohammed; Fiscal Year: 2009
    ..It will be held in Dar es Salaam, Tanzania, 11-14 November 2009...
  20. ADH and ALDH2 Genes in Tanzanian Populations
    Kenneth Kidd; Fiscal Year: 2007
    ..the Department of Biochemistry and Molecular Biology, The Hubert Kairuki Memorial University Faculty of Medicine, Dar es Salaam, Tanzania...
  21. HIV/AIDS and TB Research Training in Tanzania
    Ferdinand Mugusi; Fiscal Year: 2005
    Project Plan This is an application by Muhimbili University College of Health Sciences (MUCHS), Dar es Salaam, Tanzania for a planning grant from Fogarty International Center that will help, develop short, intermediate and long-term ..
  22. Identifying Venues and Strategies to Prevent Violence and HIV
    Suzanne Maman; Fiscal Year: 2009
    ..and characterize venues where men, 15-19 years at high risk for HIV acquisition and transmission, socialize in Dar Es Salaam, Tanzania...
  23. Evangelia G Kranias; Fiscal Year: 2016
    ..Our previous studies showed that dephosphorylated phospholamban inhibits the SERCA2 Ca-affinity and it represents a fundamental "brake" mechanism in SR Ca-cycling and cardiac contractility...
  24. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2013
    ..SERCA C674, 2) a sequence-specific antibody that recognizes irreversibly oxidized SERCA C674, and 3) heterozygote SERCA2 C674S knock-in (SKI+/-) mice that preliminary studies show have abnormal 7NO-stimulated SERCA activity and ..
  25. NUTRITION, IMMUNOLOGY, AND EPIDEMIOLOGY OF TB
    Wafaie Fawzi; Fiscal Year: 2004
    ..e. for a total of 20 months). Consenting subjects who present to 2 TB clinics in Dar es Salaam seeking care for respiratory illness will be screened for TB and HIV infection and invited to participate ..
  26. HIV PREVENTION TRIALS UNIT
    Wafaie Fawzi; Fiscal Year: 2004
    Harvard University (Boston, MA) and Muhmbili University (Dar es Salaam, Tanzania) have been involved in collaborative research for over 2 decades...
  27. Tanzania Injection Drug Use/HIV Prevention Project
    Mark Williams; Fiscal Year: 2006
    ..TAPP builds on research we have been conducting for the past two years in Dar es Salaam, Tanzania...
  28. Exercise Training in Post-infarct Heart
    Joseph Y Cheung; Fiscal Year: 2012
    ..grant period, we focused on the cardiac Na+/Ca2+ exchanger (NCX1) and sarco(endo)plasmic reticulum Ca-ATPase (SERCA2) as targets by which HIST mediated its beneficial effects...
  29. Desmoplakin Assembly and Function in Epidermis
    KATHLEEN JANEE GREEN; Fiscal Year: 2010
    ..signaling regulate DP trafficking to desmosomes by analyzing DP assembly behavior in keratinocytes in which ATP2A2/SERCA2 is impaired pharmacologically or by Darier's disease mutations or RNAi-mediated knock down;and 4...
  30. CARMELLA EVANS EVANS-MOLINA; Fiscal Year: 2016
    ..Preliminary and published work has revealed that expression of the predominant beta cell isoform, SERCA2, is markedly downregulated in rodent and human models of Type 2 diabetes mellitus...
  31. Prevalence and Correlates of Khat Use Among HIV-Positive Patients in Ethiopia
    Alan R Lifson; Fiscal Year: 2013
    ..care 500 HIV-positive adults newly enrolled for medical care will be recruited from two major HIV Clinics in Bahir Dar, and will receive a baseline and 6-month follow-up health survey including: demographic characteristics;khat, ..
  32. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..We discovered expression of dopamine receptors (DAR) in breast tissue, adipocytes and BCC...
  33. CARDIAC ION PUMPS: A MOLECULAR GENETIC APPROACH
    Paul Kessler; Fiscal Year: 1993
    ..During phase II of the award we will examine the molecular basis for the stimulation by phospholamban of the cardiac Ca2+-ATPase using recombinant DNA technology...
  34. Mary E McCaul; Fiscal Year: 2014
    ..Using positron emission technology (PET), we recently have reported robust sex differences in dopamine release (DAR) to amphetamine administration in healthy, age-matched men and women;this is the first demonstration of gender-..
  35. Antonia S New; Fiscal Year: 2016
    ..We propose here to examine the effects of DAR-0100A -- a highly selective, full, dopamine-1 receptor (D1R) agonist -- on working memory impairments in patients ..
  36. Laurie R Earls; Fiscal Year: 2014
    ..of specific miRNAs (miR-25 and miR-185) which target the expression of the Sarco/endoplasmic reticular ATPase (Serca2), a protein which pumps Ca2+ into the ER...
  37. Stanislav S Zakharenko; Fiscal Year: 2016
    ..revealed that a deletion of the microRNA-processing gene Dgcr8 upregulates sarco(endo)plasmic reticulum ATP-ase 2 (SERCA2) in excitatory neurons and leads to abnormal neurotransmitter release and LTP...
  38. Live Smart Live Safe: HIV Prevention for Youth with Intellectual Disabilities
    JENNIFER J WELLS; Fiscal Year: 2013
    ..This project is consistent with the mission of the National Institute of Mental Health Division of AIDS Research (DAR), which supports proposals designed to prevent HIV transmission among at-risk populations...
  39. Lin Wang; Fiscal Year: 2014
    ..in the normal ONH initiated by an ocular perfusion pressure change contains two phases: an initial dynamic phase (dAR) when vascular smooth muscles dilate and contract to adjust the vascular resistance in an attempt to return blood ..
  40. Theodora M Mauro; Fiscal Year: 2016
    ..Decreased Cytosolic Ca2+, Pathologic ERK Signaling Due to Abnormal Organelle Ca2+ Homeostasis, or Impaired SERCA2-dependent Nuclear Ca2+ Signaling Aim #3: To Normalize Differentiation in DD by Improving Ca2+ Homeostasis, ..
  41. Molecular mechanisms of dendrite development in mammalian CNS
    Yuh Nung Jan; Fiscal Year: 2012
    ..We propose to focus on the group of dar (dendritic arborization reduction) genes...
  42. Mechanisms Differentiating Dendrite Development from Axon Development
    Bing Ye; Fiscal Year: 2010
    ..From a genetic screen in Drosophila, we isolated several mutants (dar mutants) with reduced dendritic arbors but normal axons...
  43. Pharmacologic and Clinical Testing of a D1 Agonist for Neuropsychiatric Disorders
    Jeffrey A Lieberman; Fiscal Year: 2010
    ..from the community at large, to conduct a proof of concept study assessing the use of a selective D1 agonist, DAR-0100, in the treatment of cognitive deficit in schizophrenia. In the proposed study, two doses (10 and 30 mg, s.c...
  44. Nicholas Tarantino; Fiscal Year: 2014
    ..project specifically addresses two areas of high priority put forth by NIMH's Division of AIDS Research (DAR): (1) innovative research designed to better understand unique multilevel factors related to HIV-risk reduction, ..
  45. Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase
    ARVIN DAR; Fiscal Year: 2013
    ..KSR as a distinct signaling molecule, which functions as a dynamic scaffold of the Ras pathway (Brennan and Dar et al., Nature, 2011). In one state, KSR behaves as an inhibitor of the Ras effector MEK...
  46. David W Self; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The objective of the Basic Science Training Program in Drug Abuse Research (DAR) at UT Southwestern is the training of predoctoral and postdoctoral research fellows in a broad range of biological ..
  47. Thyroid Hormone Receptor Function in Cardiac Hypertrophy
    Kaie Ojamaa; Fiscal Year: 2006
    ..binding isoform, TR alpha 2,has the unique ability to repress T3-inducible transcription of cardiac alpha-MHC and SERCA2 genes...
  48. Measuring Oral Disease Burden for Planning Services
    Michael Ross; Fiscal Year: 2003
    ..The principal investigator is based in Houston, Texas (USA) and the collaborators are based in Cape Town (South Africa), Dar es Salaam (Tanzania), and London (UK).
  49. Trangenic Remodeling of the Rabbit Heart
    Jeffrey Robbins; Fiscal Year: 2006
    ..We hypothesize that altering PLB levels or its phosphorylation status will alter the SR Ca2+-ATPase activity (SERCA2), leading to changes in overall contractility and the heart's responses to (beta-adrenergic stimulation...
  50. TRANSGENIC MICE WITH ALTERED CALCIUM HANDLING
    Evangelia Kranias; Fiscal Year: 2003
    ..Relaxation is mediated by the transport of Ca2+into the SR lumen by the Ca2+-ATPase (SERCA2), which is under regulation by phospholamban (PLB) in cardiac, slow-twitch skeletal and smooth muscles...
  51. D4 Receptor-Mediated Effects of Methylphenidate in Mice
    David Grandy; Fiscal Year: 2007
    ..Of the five known DAR subtypes, recent family and twin studies have revealed an association between an allele of the human DA D4R gene (..
  52. The Role of Phospholamban in Ischemia: Transgenic Appro*
    Evangelia Kranias; Fiscal Year: 2005
    ..A decrease in the activity of the SR Ca2+ pump (SERCA2), and/or in the rate of Ca2+ reuptake by the SR have been described in several species, including patients ..
  53. SR Ca2+ ATPase, a determinant of cardiac contractility
    Muthu Periasamy; Fiscal Year: 2007
    ..To better define the role of decreased SERCA pump expression we developed a SERCA2 gene knockout (-/+) model...
  54. CA TRANSPORTER EXPRESSION IN HYPERTROPHY & HEART FAILURE
    Allen Samarel; Fiscal Year: 2003
    ..There is now substantial evidence to indicate that expression levels of SERCA2 and NCX1, the major Ca2+ transporters in cardiac muscle, are profoundly altered in the failing human ventricular ..
  55. Therapeutic for the Negative Symptoms of Schizophrenia
    RONALD NARDI; Fiscal Year: 2006
    ..DarPharma has developed DAR 0200A, a high affinity dopamine D1 full agonist with full intrinsic activity...
  56. Analyzing the function of the Parkinson's Disease gene dardarin using Drosophila.
    Mark W Dodson; Fiscal Year: 2010
    ..dardarin (dar), the most recently identified PD gene, encodes a large protein belonging to a novel protein family with Ras/GTPase ..
  57. The ER Stress Response and ATF6 Activation in the Heart
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007
    ..We have shown that in cardiac myocytes, SR/ER Ca ATPase-2 (SERCA2) is induced in an ER stress- and ATF6 alpha-dependent manner...
  58. Ventilated Caging Systems and Change Stations to Protect Rodents and Personnel
    LYNDON GOODLY; Fiscal Year: 2007
    ..This proposal is a request by the University of Illinois at Urbana-Champaign (UIUC) Division of Animal Resources (DAR) to purchase twenty seven (27) ventilated caging systems (VCS), and ten (10) changing stations (CS)...
  59. Novel Pharmacotherapy for Parkinson's Disease
    LAURENE WANG SMITH; Fiscal Year: 2003
    ..The milestones to be achieved will include: 1. Conclude a broad-based receptor screening profile for DAR-201; 2...
  60. Mechanisms Differentiating Dendrite Development from Axon Development
    Bing Ye; Fiscal Year: 2007
    ..From a genetic screen in Drosophila, we isolated several mutants (dar mutants) with reduced dendritic arbors but normal axons...
  61. HYPOXIA-INDUCED TRANSCRIPTION IN CARDIOVASCULAR FUNCTION
    Frank Giordano; Fiscal Year: 2004
    ..HIF1alpha responsive genes, and have discovered that augmented HIF-1alpha signaling results in a decrease of SERCA2 transcripts; a finding that may have implications regarding the effects of hypoxia/ischemia on cardiac contractile ..
  62. CARDIOVASCULAR GENE THERAPY CENTER
    Joseph Glorioso; Fiscal Year: 2005
    ..using vector mediated delivery to AV grafts using adenovirus iNOS gene therapy, (ii) to develop an AAV-6-SERCA2 gene vector for enhancing calcium transients to improve cardiomyocyte function in of heart failure patients on ..
  63. The effect of ART on sexual risk behavior in Chennai, India
    Caitlin Kennedy; Fiscal Year: 2009
    ..This study examines the effect of ART on sexual risk behavior among HIV-positive individuals in Dar es Salaam, Tanzania...
  64. Regulation of cardiac ion channels
    Nipavan Chiamvimonvat; Fiscal Year: 2004
    ..3.) Finally, by using a transgenic knockout model of the SERCA2 gene, we will directly test our hypothesis in a model with reduced Ca2+-induced Ca2+ release using similar ..
  65. CARDIAC DYSFUNCTION, AIDS AND COCAINE
    William Lewis; Fiscal Year: 2003
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  66. Partnership on Nutrition and HIV/AIDS Research in Tanza*
    Wafaie Fawzi; Fiscal Year: 2006
    ..The program will be carried out as a collaborative effort between Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania and the Harvard School of Public Health, Boston, MA.