SENP2

Summary

Gene Symbol: SENP2
Description: SUMO1/sentrin/SMT3 specific peptidase 2
Alias: AXAM2, SMT3IP2, sentrin-specific protease 2, SMT3-specific isopeptidase 2, SUMO1/sentrin/SMT3 specific protease 2, sentrin/SUMO-specific protease SENP2
Species: human

Top Publications

  1. pmc SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
    James Witty
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U K
    Biochem J 428:247-54. 2010
  2. pmc Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Yoko Itahana
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Box 7512, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Mol Cell Biol 26:4675-89. 2006
  3. pmc SUMO-specific protease 2 in Mdm2-mediated regulation of p53
    M Jiang
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Cell Death Differ 18:1005-15. 2011
  4. pmc The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex
    Jacqueline Goeres
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Biol Cell 22:4868-82. 2011
  5. pmc Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
    Kin Hoe Chow
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA
    Nucleus 3:349-58. 2012
  6. pmc SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
    Caelin Cubeñas-Potts
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205
    Mol Biol Cell 24:3483-95. 2013
  7. ncbi Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    Jowita Mikolajczyk
    Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:26217-24. 2007
  8. ncbi Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
    Limin Gong
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:15869-77. 2006
  9. ncbi Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation
    T Nishida
    School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 276:39060-6. 2001
  10. ncbi Association of the human SUMO-1 protease SENP2 with the nuclear pore
    Jun Hang
    Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
    J Biol Chem 277:19961-6. 2002

Research Grants

  1. p90RSK: A flow responsive mediator of inflammation
    Keigi Fujiwara; Fiscal Year: 2013
  2. Yuan Chen; Fiscal Year: 2015

Scientific Experts

  • Jiayu Liao
  • Francisco C Villafuerte
  • Thomas G Hofmann
  • Theodora E Danciu
  • Ji Li
  • Marco Orsetti
  • CHRISTOPHER LIMA
  • Jowita Mikolajczyk
  • Xiao Ning Wang
  • Renato A S Oliveira
  • Coby B Carlson
  • Reiko Ban
  • Edward T H Yeh
  • Keigi Fujiwara
  • Jinke Cheng
  • Yuan Chen
  • Zheng Xu
  • David Reverter
  • Mary Dasso
  • Kin Hoe Chow
  • Sung Soo Chung
  • Hye Seung Jung
  • Jun Wang
  • Young Eun Kwon
  • Sung Jun Bae
  • Yitao Qi
  • Byung Yong Ahn
  • Moon Hee Lee
  • Debaditya Mukhopadhyay
  • Shang Yi Chiu
  • Nagamalleswari Kolli
  • Michael J Matunis
  • Sanna Kaikkonen
  • Ulla Karvonen
  • Keith D Wilkinson
  • Alicja Mirecka
  • Wenwen Zhang
  • Fei Fei Wang
  • Matthew M Hsieh
  • Hua Wang
  • Rui Xue Xu
  • Yoshinori Tatemichi
  • Jelena Rajković
  • Jun Xu
  • Mingyue Tan
  • Thiziri Nait Achour
  • Qing feng Jiang
  • Jiang Fu
  • Kamela O Alegre
  • Yi Feng Yuan
  • Ding Yen Lin
  • Nina Schweizer
  • Caelin Cubeñas-Potts
  • Myungjin Kim
  • Gholamreza Bidkhori
  • Chiung Min Wang
  • Shuang Tang
  • Kyung Sun Heo
  • Chao Tong
  • Ming Yue Tan
  • Jae Hong Seol
  • Guochang Huang
  • Weina Ju
  • Hong Yi Kuo
  • Ho Seon Park
  • Katharine S Ullman
  • Suzanne Elgort
  • Guy Salvesen
  • Hong Zhang
  • Marcin Drag
  • Huo Jian Shen
  • Seong Won Lee
  • Masaharu Uno
  • Tsung I Hsu
  • Eun Young Kim
  • Yong Ran
  • M Jiang
  • Chin Ha Chung
  • Vadim Rimsa
  • Wei Hsu
  • Masatomo Watanabe
  • Jacqueline Goeres
  • Min Kim
  • Kyong Soo Park
  • James Witty
  • Zhen Bo Wang
  • Xunlei Kang
  • Beau J Fenner
  • Yonggang Wang
  • Mei Ren Pan

Detail Information

Publications93

  1. pmc SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
    James Witty
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U K
    Biochem J 428:247-54. 2010
    ..Partial redundancy of function with SENP2 is revealed by combinatorial knockdown studies...
  2. pmc Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Yoko Itahana
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Box 7512, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Mol Cell Biol 26:4675-89. 2006
    ..bipartite nuclear localization signal (NLS) and a CRM1-dependent nuclear export signal (NES) in the SUMO protease SENP2. Both the NLS and the NES are located in the nonhomologous domains of SENP2 and are not conserved among other ..
  3. pmc SUMO-specific protease 2 in Mdm2-mediated regulation of p53
    M Jiang
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Cell Death Differ 18:1005-15. 2011
    Genetic analysis in mice has revealed a key genetic pathway, SUMO-specific protease 2 (SENP2)-Mdm2-p53, essential for trophoblast development...
  4. pmc The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex
    Jacqueline Goeres
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Biol Cell 22:4868-82. 2011
    ..In this study, we have characterized the molecular basis for interactions between SENP2 and NPCs in human cells...
  5. pmc Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
    Kin Hoe Chow
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA
    Nucleus 3:349-58. 2012
    Numerous enzymes of the mammalian SUMO modification pathway, including two members of the SUMO protease family, SENP2 and SENP1, localize to the nuclear periphery...
  6. pmc SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
    Caelin Cubeñas-Potts
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205
    Mol Biol Cell 24:3483-95. 2013
    ..Here we show that the small ubiquitin-related modifier (SUMO)-specific isopeptidases SENP1 and SENP2 are targeted to kinetochores in mitosis...
  7. ncbi Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    Jowita Mikolajczyk
    Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:26217-24. 2007
    ..Broadly speaking, SENP1 is the most efficient endopeptidase, whereas SENP2 and -5-7 have substantially higher isopeptidase than endopeptidase activities...
  8. ncbi Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
    Limin Gong
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:15869-77. 2006
    ..Of the six SENP family members, except for SENP1 and SENP2, the substrate specificities of the rest of SENPs are not well defined...
  9. ncbi Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation
    T Nishida
    School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Biol Chem 276:39060-6. 2001
    A novel SUMO-1/Smt3-specific isopeptidase, SMT3IP2/Axam2 (Smt3-specific isopeptidase 2), was cloned and characterized...
  10. ncbi Association of the human SUMO-1 protease SENP2 with the nuclear pore
    Jun Hang
    Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
    J Biol Chem 277:19961-6. 2002
    ..To understand these enzymes better, we have examined the localization and behavior of the human SUMO-1 protease SENP2. Here we have shown that SENP2 associates with the nuclear face of nuclear pores and that this association ..
  11. pmc Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
    Hong Zhang
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 22:6498-508. 2002
    ..We show that SENP2, a SUMO protease that is able to demodify both SUMO-1 and SUMO-2 or SUMO-3 protein conjugates, localizes to the ..
  12. ncbi SUMO-1 protease-1 regulates gene transcription through PML
    Jennifer L Best
    Division of Hematology Oncology, Children s Hospital, Department of Medicine, Boston, MA 02115, USA
    Mol Cell 10:843-55. 2002
    ..SuPr-1 action on transcription was enhanced by PML, and SuPr-1 failed to activate transcription in PML-deficient fibroblasts. Our studies establish an important role for SUMO proteases in transcription...
  13. ncbi A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
    David Reverter
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Structure 12:1519-31. 2004
    ..X-ray structures of the human Senp2 catalytic protease domain and of a covalent thiohemiacetal transition-state complex obtained between the Senp2 ..
  14. pmc Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death
    Yitao Qi
    Texas Heart Institute, Houston, TX 77030, USA Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neuron 83:1159-71. 2014
    ..Here we show that mice with partial deficiency of Sentrin/SUMO-specific protease 2 (SENP2) develop spontaneous seizures and sudden death...
  15. pmc Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
    Nina Schweizer
    J Cell Biol 203:883-93. 2013
    ..we provide evidence that Tpr might spatially regulate SAC proteostasis through the SUMO-isopeptidases SENP1 and SENP2 at NPCs...
  16. pmc Transcriptional repression of estrogen receptor α signaling by SENP2 in breast cancer cells
    Thiziri Nait Achour
    Institut de Recherche en Cancérologie de Montpellier, Institut de Recherche en Cancérologie de Montpellier, INSERM, Unité 896, Universite Montpellier 1, and Institut régional du Cancer Montpellier, Montpellier T N A, C T, A L, V C, S J, F 34298, France Université Lyon 1 S S, A P, L C, F 69000 Lyon, France INSERM Unité 1052, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5286, Centre de Recherche en Cancérologie de Lyon, Equipe labellisée, La Ligue, F 69008 Lyon, France and Institut des Sciences Pharmaceutiques et Biologiques S S, Faculté de Pharmacie de Lyon, Universite Lyon 1, F 69000 Lyon, France
    Mol Endocrinol 28:183-96. 2014
    ..of the small ubiquitin-related modifier (SUMO) protease, SUMO1/sentrin/suppressor of Mif 2-specific peptidase 2 (SENP2), in the regulation of ERα activity...
  17. doi SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell
    Qing feng Jiang
    Department of Hepatobiliary Surgery, Henan Provincial People s Hospital, Zhengzhou, 450003, Henan, China
    Tumour Biol 35:9677-82. 2014
    ..The SUMO proteases (SENP) remove SUMO conjugate from proteins, and their expression is deregulated in cancers. SENP2 has been reported to play a critical role in the control of hepatocellular carcinoma (HCC) cell growth by ..
  18. doi SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders
    Matthew M Hsieh
    Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md Electronic address
    Exp Hematol 44:483-490.e2. 2016
    ..Thus, HbF and other classic erythropoietic parameters did not differ between healthy and CMS individuals. However, the non-G/G genotypes of SENP1 appeared to differentiate individuals with CMS from healthy Andean highlanders. ..
  19. ncbi Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification
    Thomas G Hofmann
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Martinistrasse 52, 20251 Hamburg, Germany
    J Biol Chem 280:29224-32. 2005
    ..SuPr-1 deconjugates SUMO-1 from HIPK2 in vitro and in vivo, which results in modestly increased HIPK2-induced JNK activity. Thus, our data demonstrate that HIPK2 effector function on JNK is modulated through dynamic SUMO-1 modification...
  20. pmc SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1
    Mingyue Tan
    Department of Urology, Shanghai First People s Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200080, China
    Sci Rep 5:13996. 2015
    ..Recently, we reported that small ubiquitin related modifier (SUMO)-specific protease 2 (SENP2) was downregulated in BC specimen...
  21. pmc Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi
    Jelena Rajković
    From the Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova cesta 39, SI 1000 Ljubljana, Slovenia, the Jožef Stefan International Postgraduate School, Jamova cesta 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 290:28231-44. 2015
    ..2, but not by HsAtg4B nor by the structurally related human proteases SENP1, SENP2, and UCH-L3.
  22. doi DNA damage-induced NF-κB activation in human glioblastoma cells promotes miR-181b expression and cell proliferation
    Rui Xue Xu
    Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China
    Cell Physiol Biochem 35:913-25. 2015
    ..Unfortunately, the vast majority of GBM patients fail responding to radiotherapy because GBM cells remain highly resistant to radiation. Radiotherapy-induced DNA damage response may correlate with therapeutic resistance...
  23. pmc Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration
    Jiang Fu
    Department of Biomedical Genetics, Center for Oral Biology, Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Genet 10:e1004579. 2014
    ..Here we show that mice with neural-specific disruption of SENP2 develop movement difficulties which ultimately results in paralysis...
  24. pmc Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia
    Fei Fei Wang
    Institute for Pediatric Translational Medicine, Shanghai Children s Medical Center of Shanghai Jiao Tong University, Shanghai 200127, P R China Shanghai YiBeiRui Biotechnology Co, Ltd, Shanghai 201318, P R China
    Oncol Lett 12:3755-3762. 2016
    ....
  25. pmc Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer
    Alicja Mirecka
    Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
    Pathol Oncol Res 22:817-23. 2016
    ..1691 + 36C > T, rs12297820) and SENP2 gene (c.902C > A, p.Thr301Lys, rs6762208) and a risk of breast cancer occurrence...
  26. doi SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation
    Yi Feng Yuan
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People s Republic of China
    Mol Reprod Dev 81:712-24. 2014
    ..the localization of SUMO-1 during oocyte meiosis, and that overexpression of Sentrin/SUMO-specific protease 2 (SENP2), a de-SUMOylation protease, altered SUMO-modified proteins, and caused defects in metaphase-II spindle ..
  27. doi SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling
    Jun Xu
    Graduate School of Anhui Medical University, Hefei, PR China Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, PR China
    Biochem Biophys Res Commun 460:409-15. 2015
    ..These results delineate a key role for Senp1in IL-6 induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM. ..
  28. pmc Structural insights into the SENP6 Loop1 structure in complex with SUMO2
    Kamela O Alegre
    Institut de Biotecnologia i de Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain
    Protein Sci 23:433-41. 2014
    ..To gain structural insights into the role of Loop1, we have designed a chimeric SENP2 with the insertion of Loop1 into its sequence. The structure of SENP2-Loop1 in complex with SUMO2 was solved at 2...
  29. pmc Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification
    Yoshinori Tatemichi
    Department of Tumor Biology, Institute of Biomedical Sciences, Iwate Medical University, Yahaba Cho, Japan
    Cancer Sci 106:848-56. 2015
    ..Our study demonstrates that NACC1 can be modified by SUMO paralogues, and cooperates with PML protein. ..
  30. pmc New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain Sickness
    Francisco C Villafuerte
    Laboratorio de Fisiología Comparada, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
    J Appl Physiol (1985) 119:1481-6. 2015
    ..This minireview discusses recent genetic findings potentially underlying EE and CMS, and their possible physiological mechanisms in Andean highlanders. ..
  31. pmc Coamplification and cooperation: toward identifying biologically relevant oncogenes
    Guochang Huang
    Authors Affiliation Laboratory of Epithelial Cancer Biology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Clin Cancer Res 19:5549-51. 2013
    ..Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas...
  32. pmc Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa
    Hye Seung Jung
    a Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Islets 8:207-216. 2016
    ..Treatment with 25 mM glucose for 72 h induced Senp2 mRNA expression but not that of Senp1 in INS1 cells...
  33. doi SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma
    Wenwen Zhang
    Department of Gastroenterology, Shenyang General Hospital of PLA, 83 Wenhua Road, Shenyang, 110016, People s Republic of China
    Tumour Biol 37:7741-8. 2016
    ..The EMT-related transcription factor Zeb1 was SUMO-modified and decreased in Senp1-silenced HCC cells. These results delineate that senp1 might play an important role in the regulation of HGF-induced invasion and migration of HCC cells. ..
  34. pmc The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
    Kin Hoe Chow
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 Laboratory of Gene Regulation and Development, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322
    Mol Biol Cell 25:160-8. 2014
    ..two pore-associated small ubiquitin-like modifier (SUMO) proteases, sentrin/SUMO-specific protease 1 (SENP1) and SENP2, we observe that many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are ..
  35. doi SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells
    Ming Yue Tan
    Department of Urology, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, China
    Cell Physiol Biochem 32:542-8. 2013
    SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member which has an indispensable role in the regulation of NF-κB transcriptional activation and Wnt signaling...
  36. pmc Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2
    Theodora E Danciu
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA
    J Biol Chem 287:18318-29. 2012
    ..reconstituted in vitro with purified components and can be reversed in vitro by treatment with the SUMO protease SENP2. SUMOylation of FOXC1 and FOXC2 occurs primarily on one consensus synergy control motif with minor contributions ..
  37. doi A proteomic insight into the effects of the immunomodulatory hydroxynaphthoquinone lapachol on activated macrophages
    Renato A S Oliveira
    Leukocyte Biology Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Int Immunopharmacol 14:54-65. 2012
    ..This study also constitutes a model for the pre-in-vivo evaluation of drug actions...
  38. doi Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth
    Tsung I Hsu
    Institute of Basic Medical Sciences, College of Medicine, Institute of Bioinformatics and Biosignal Transduction, National Cheng Kung University, Tainan, Taiwan
    Mol Pharmacol 82:1115-28. 2012
    ..Taken together, the results of this study clarify the mechanism of BA-mediated Sp1 degradation and identify a pivotal role for Sp1 in the BA-induced repression of lung cancer growth...
  39. pmc SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
    Seong Won Lee
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    EMBO J 31:4441-52. 2012
    ..During later periods after UV exposure, however, SENP2 removed SUMO from hnRNP-K for its destabilization and in turn for release from cell-cycle arrest...
  40. ncbi SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of β-catenin
    Huo Jian Shen
    Department of General Surgery, RenJi Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Asian Pac J Cancer Prev 13:3583-7. 2012
    ..Here, we demonstrated that SENP2 plays a critical role in the control of hepatocellular carcinoma cell growth...
  41. doi SUMOylation negatively regulates the stability of CHFR tumor suppressor
    Young Eun Kwon
    School of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 430:213-7. 2013
    ..Moreover, protein level of CHFR, not CHFR(K663R), is rapidly declined under SUMOylation-promoting conditions, and SENP2 deSUMOylating enzyme reverses its SUMO-modification...
  42. pmc SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons
    Weina Ju
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
    Channels (Austin) 7:153-9. 2013
    ..CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant...
  43. pmc Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism
    Shuang Tang
    Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    PLoS ONE 8:e63965. 2013
    ..Here we report that SUMO-specific protease 2 (SENP2) negatively regulates aerobic glycolysis in MCF7 and MEF cells...
  44. pmc Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
    Joris Hemelaar
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 24:84-95. 2004
    ..The UBL probes described here will be valuable tools for the further characterization of the enzymatic pathways that govern modification by UBLs...
  45. pmc De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
    Kyung Sun Heo
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 112:911-23. 2013
    ..Disturbed flow induces proinflammatory and apoptotic responses in endothelial cells, causing them to become dysfunctional and subsequently proatherogenic...
  46. doi CHFR is negatively regulated by SUMOylation-mediated ubiquitylation
    Sung Jun Bae
    School of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 433:194-9. 2013
    ..Conversely, SENP2 deSUMOylating enzyme reduces SUMOylation-induced ubiquitylation of CHFR, leading to elevated CHFR protein levels...
  47. ncbi Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
    Ding Yen Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    Mol Cell 24:341-54. 2006
    ..Our results provide mechanistic insights into Daxx in SUMO-dependent transcriptional control and subnuclear compartmentalization...
  48. pmc Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
    Chao Tong
    1615 Biomedical Research Bldg, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences University at Buffalo SUNY, 3435 Main St, Buffalo, NY 14214, USA
    FASEB J 27:4332-42. 2013
    ..Moreover, cardiac overexpression of desumoylase, sentrin-specific protease 2 (SENP2), significantly reduces nuclear sumoylated SIRT1 levels (P<0.05)...
  49. doi SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene
    Chiung Min Wang
    Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA
    J Cell Biochem 114:589-98. 2013
    ..In addition, PIAS3β (a SUMO E3 ligase) enhanced and SENP2 and SENP7 (two SUMOylation proteases) decreased SUMOylation of ATF3, respectively...
  50. pmc Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma
    Gholamreza Bidkhori
    Laboratory of Systems Biology and Bioinformatics LBB, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    PLoS ONE 8:e67552. 2013
    ..In addition to the mentioned genes, there are some other genes (i.e. DLGAP5, BIRC5, PSMD2, Src, TTK, SENP2, PSMD2, DOK2, FUS and etc.) in the modules.
  51. doi Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
    Masaharu Uno
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 22:5169-73. 2012
    ..Compound 4 exhibited selective inhibition against SENP1 protease activity without inhibiting other protease enzyme activities in vitro...
  52. pmc Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction
    Eun Young Kim
    Program in Genes and Development, The University of Texas Health Science Center at Houston, USA
    J Mol Cell Cardiol 52:638-49. 2012
    ..and function and its underlying mechanisms, we generated transgenic (Tg) mice with cardiac-specific expression of SENP2, a SUMO-specific protease that deconjugates sumoylated proteins, to evaluate the impact of desumoylation on heart ..
  53. doi ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator
    Ulla Karvonen
    Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki, P O Box 63, FI 00014, Helsinki, Finland
    J Mol Biol 382:585-600. 2008
    ..the nuclear compartmentalization of ZNF451, since coexpression of ZNF451 with SUMO-specific proteases SENP1 or SENP2, both capable of desumoylating the protein, redistributes ZNF451 from nuclear domains to speckles and nucleoplasm...
  54. pmc Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts
    Kristin E Yates
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Aging Cell 7:609-21. 2008
    ..repression of the genes encoding the small ubiquitin-related modifier (SUMO)-specific proteases, Senp1, Senp2, and Senp7, induced low passage primary human fibroblasts to senesce rapidly...
  55. pmc Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
    Zheng Xu
    Department of Biochemistry and Molecular Biotechnology Program, Centre for Protein Science and Crystallography, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biochem J 398:345-52. 2006
    ..1 nm), the X-ray structure of SENP1C(C603S)-SUMO-1 complex. A comparison of the structure of SENP2-SUMO-1 suggests strongly that SUMO-specific proteases require a self-conformational change prior to cleavage of ..
  56. doi SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells
    Sanna Kaikkonen
    Institute of Biomedicine Medical Biochemistry, University of Kuopio, FI 70211 Kuopio, Finland
    Mol Endocrinol 23:292-307. 2009
    ..Of the SUMO-specific proteases (SENP)-1, -2, -3, -5, and -6, only SENP1 and SENP2 are efficient in cleaving AR-SUMO-1 conjugates in intact cells and in vitro...
  57. pmc Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin
    Takayuki Kadoya
    Department of Biochemistry, Faculty of Medicine, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    Mol Cell Biol 22:3803-19. 2002
    ..These results demonstrate that Axam functions as a desumoylation enzyme to downregulate beta-catenin and suggest that sumoylation is involved in the regulation of the Wnt signaling pathway...
  58. pmc Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1
    Zheng Xu
    Department of Biochemistry, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biochem J 386:325-30. 2005
    ..Taken together, we suggest that the observed differential maturation process has its physiological significance in the regulation of the sumoylation pathway...
  59. ncbi Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases
    Jinke Cheng
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:14492-8. 2005
    ..that c-Jun transcription can be regulated by SuPr-1, an alternatively spliced form of SUMO-specific protease 2 (SENP2)...
  60. ncbi Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation
    Ki Sa Sung
    Department of Biological Science, Sungkyunkwan University, 300 Chunchundong, Suwon 440 746, Korea
    FEBS Lett 579:3001-8. 2005
    ..These results suggest that phosphorylation-dependent sumoylation enables HIPK2 to drive different target gene transcription by means of differential interactions with its binding partners...
  61. ncbi Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)
    Imke M Veltman
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 14:1955-63. 2005
    ..Together, the constitutional t(12;15)(q13;q25) translocation revealed two novel candidate genes for neonatal/infantile GCT development: MESDC2 and SENP1...
  62. pmc SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx
    Hong Yi Kuo
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 11529, Republic of China
    Proc Natl Acad Sci U S A 102:16973-8. 2005
    ..either individually or in combination enhanced CBP transcriptional activity, and expression of a SUMO protease SENP2 potentiated the transcriptional activity of CBP wild-type but not its sumoylation mutant, indicating that SUMO ..
  63. pmc The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
    Lin Nan Shen
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Scotland KY16 9ST, UK
    Biochem J 397:279-88. 2006
    ..Although SENP1 is rather similar in structure to the related protease SENP2, these proteases have different SUMO-processing activities...
  64. ncbi Differential regulation of sentrinized proteins by a novel sentrin-specific protease
    L Gong
    Research Center for Cardiovascular Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases, Division of Molecular Medicine, The University of Texas Houston Health Science, Houston, USA
    J Biol Chem 275:3355-9. 2000
    ..The identification of a nuclear-localized, sentrin-specific protease will provide a unique tool to study the role of sentrinization in the biological function of PML and in the pathogenesis of acute promyelocytic leukemia...
  65. ncbi Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
    David Reverter
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Struct Mol Biol 13:1060-8. 2006
    ..SUMO isoform processing and SUMO isoform interactions, X-ray structures were determined for a catalytically inert SENP2 protease domain in complex with conjugated RanGAP1-SUMO-1 or RanGAP1-SUMO-2, or in complex with SUMO-2 or SUMO-3 ..
  66. pmc SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5
    Mark D Benson
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
    Proc Natl Acad Sci U S A 104:1805-10. 2007
    ..5 serves as a substrate in a minimal in vitro reconstituted SUMOylation reaction. The SUMO-specific proteases SENP2 and Ulp1 efficiently deconjugate SUMO from Kv1...
  67. pmc An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
    Nicolas Stankovic-Valentin
    CNRS UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, BP 447, 59017 Lille Cedex, France
    Mol Cell Biol 27:2661-75. 2007
    ..of the other conserved residue in the psiKXE consensus, E316A, or the overexpression of the deSUMOylase SSP3/SENP2. Furthermore, HIC1 is acetylated in vitro by P300/CBP...
  68. ncbi Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation
    Zheng Xu
    Centre of Protein Science and Crystallography, Department of Biochemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong
    FASEB J 22:127-37. 2008
    ..modification confers a higher recovery of enzyme activity, which is also observed in yeast Ulp1, but not in human SENP2, suggesting its protective role against irreversible sulfhydryl oxidation...
  69. doi Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-kappaB signaling pathways
    Fumio Yoshitake
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1 8, Yamada oka Suita, Osaka, 565 0871 Japan
    J Biol Chem 283:11535-40. 2008
    ..of MKP1 and MKP7, which encode enzymes that dephosphorylate JNK, and down-regulates the transcription of Senp2 and Cul4A, which are related to the ubiquitin pathway...
  70. doi Ubc9 promotes the stability of Smad4 and the nuclear accumulation of Smad1 in osteoblast-like Saos-2 cells
    Koichi Shimada
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Bone 42:886-93. 2008
    ..showed that sumoylated Smad4 is present and dependent on Ubc9 in vitro, which was confirmed by pretreatment with Senp2, a SUMO-protease. These results suggest that Ubc9 promotes the stability of sumoylated Smad4...
  71. doi Regulation of Wnt signaling by the nuclear pore complex
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 134:1961-71, 1971.e1-4. 2008
    ..However, beta-catenin has no nuclear localization signal, and the mechanisms by which beta-catenin is imported into the nucleus and forms a complex with the TCF-4 nuclear protein are poorly understood...
  72. pmc Distribution and paralogue specificity of mammalian deSUMOylating enzymes
    Nagamalleswari Kolli
    Department of Biochemistry, Emory University, Atlanta, GA 30322, U S A
    Biochem J 430:335-44. 2010
    ..Compared with cSENPs, recombinant full-length SENP1 and SENP2 show differences in SUMO selectivity, indicating that paralogue specificity is influenced by the presence of the ..
  73. doi Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats
    Marco Orsetti
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche DiSCAFF, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    Pharmacogenet Genomics 19:600-12. 2009
    ..The aim of this study was to investigate the molecular mechanism(s) of QTP antidepressant effect by coupling the CMS protocol with Affymetrix microarray technology to screen the entire rat genome for gene changes in the frontal cortex...
  74. doi A toolbox approach to high-throughput TR-FRET-based SUMOylation and DeSUMOylation assays
    Coby B Carlson
    Invitrogen Discovery Assays and Services, Madison, Wisconsin 53719, USA
    Assay Drug Dev Technol 7:348-55. 2009
    ..7) with high signal-to-background levels. Together, this collection of tools can be utilized in a modular approach to develop HTS assays for inhibitors of SUMOylation or deSUMOylation...
  75. ncbi [Prokaryotic expression and identification of dual-fluorescence fusion proteins of small ubiquitin-like modifier and sentrin-specific protease]
    Xiaohui Wang
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China
    Sheng Wu Gong Cheng Xue Bao 25:701-7. 2009
    ..The fusion proteins of SENP and ECFP-SUMO-EYFP can be successfully expressed in prokaryotic expression system. It lays the foundation for the fluorescence resonance energy transfer analysis...
  76. doi Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells
    Mei Ren Pan
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Cell Sci 122:3358-64. 2009
    ..This effect is SUMO-dependent because ectopic expression of SUMO-specific protease 2 (SENP2) effectively reduced Prox1 sumoylation and Prox1-induced VEGFR3 expression...
  77. pmc Identification and developmental expression of Xenopus laevis SUMO proteases
    Yonggang Wang
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8462. 2009
    ..In contrast, Xenopus possess a single member of the SENP1/SENP2 subfamily of Ulp/SENPs, most closely related to mammalian SENP1...
  78. pmc Expanding the substantial interactome of NEMO using protein microarrays
    Beau J Fenner
    Centre for Human Proteomics and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 5:e8799. 2010
    ..Binding of NEMO to several interactors, including CALB1, CDK2, SAG, SENP2 and SYT1, was confirmed using GST pulldown assays and coimmunoprecipitation, validating the initial screening ..
  79. pmc Control of adipogenesis by the SUMO-specific protease SENP2
    Sung Soo Chung
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and Department of Internal Medicine, College of Medicine, Seoul National University, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Mol Cell Biol 30:2135-46. 2010
    Here, we demonstrate that SENP2, a desumoylating enzyme, plays a critical role in the control of adipogenesis...
  80. pmc SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    Shang Yi Chiu
    Department of Biomedical Genetics, Center for Oral Biology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    PLoS Biol 6:e310. 2008
    SUMO-specific protease 2 (SENP2) modifies proteins by removing SUMO from its substrates...
  81. pmc SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
    Xunlei Kang
    The Department of Biochemistry and Molecular and Cell Biology, The Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Cell 38:191-201. 2010
    SUMO-specific protease 2 (SENP2) has a broad de-SUMOylation activity in vitro. However, the biological function of SENP2 is largely unknown...
  82. pmc The SUMO pathway functions in mouse oocyte maturation
    Zhen Bo Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 9:2640-6. 2010
    ..the two basic proteins in the sumoylation pathway and investigated their roles through over-expression of Senp2 during mouse oocyte maturation...
  83. doi BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body
    Takeshi Kuwata
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Cells 13:931-40. 2008
    ..We also show that SENP2, a SUMO specific peptidase, is co-localized in the nuclear body...
  84. doi SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor γ in C2C12 myotubes
    Sung Soo Chung
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Biochem J 433:155-61. 2011
    ..We found that the SUMO-specific protease SENP2 [SUMO1/sentrin/SMT3 (suppressor of mif two 3 homologue 1)-specific peptidase 2] effectively de-SUMOylates PPARγ-..
  85. doi Transcriptional ERRgamma2-mediated activation is regulated by sentrin-specific proteases
    Moritz Hentschke
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Biochem J 419:167-76. 2009
    ..Together, our results demonstrate reversible phosphorylation-dependent sumoylation as a means to regulate the activity of an orphan nuclear receptor...
  86. pmc The role of Co²+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols
    Vadim Rimsa
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:442-5. 2011
    ..High-throughput automated re-refinement protocols also failed to mark the Co(2+) position, supporting the requirement for the incorporation of as much information as possible to enhance the value of such protocols...
  87. doi Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1
    Masatomo Watanabe
    Laboratory of Molecular and Cellular Neuroscience, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769 2193, Japan
    Biochim Biophys Acta 1814:900-7. 2011
    ..On the other hand, SUMO-1 was deconjugated from nNOS by SENP1 and SENP2. Overall, this study has newly identified that nNOS is posttranslationally modified by SUMO-1.
  88. doi Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
    Reiko Ban
    Department of Biochemistry, Shimane University School of Medicine, Izumo 693 8501, Japan
    Genes Cells 16:652-69. 2011
    ..dramatically enhanced poly-SUMO-2/3 conjugation of Aurora-B, whereas the SUMO-specific isopeptidase SENP2 (Sentrin/SUMO-specific protease) specifically deconjugated SUMO from Aurora-B...
  89. pmc NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress
    Moon Hee Lee
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Mol Cell 43:180-91. 2011
    ..Here we show that among the six known Sentrin/SUMO-specific proteases (SENPs), only SENP2 can efficiently associate with NEMO, deSUMOylate NEMO, and inhibit NF-κB activation induced by DNA damage...
  90. doi SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
    Yong Ran
    College of Life Sciences, Wuhan University, China
    J Mol Cell Biol 3:283-92. 2011
    ..Overexpression of SENP2 caused IRF3 deSUMOylation, K48-linked ubiquitination, and degradation, whereas depletion of SENP2 had opposite ..
  91. doi SUMOylation of RORalpha potentiates transcriptional activation function
    Eun Ju Hwang
    Department of Biological Sciences, Research Center for Women s Disease, Sookmyung Women s University, 52 Hyochangwon gil, Yongsan gu, Seoul 140 742, South Korea
    Biochem Biophys Res Commun 378:513-7. 2009
    ..PIAS family members, PIASxalpha, PIAS3, and PIASy, increased SUMOylation of RORalpha, whereas SENP2 specifically removed SUMO from RORalpha...
  92. pmc Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7
    Christopher D Lima
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    J Biol Chem 283:32045-55. 2008
    ..4 angstroms. Comparison with structures of human SENP1 and SENP2 reveals unique elements that differ from previously characterized structures of SUMO-deconjugating enzymes...

Research Grants2

  1. p90RSK: A flow responsive mediator of inflammation
    Keigi Fujiwara; Fiscal Year: 2013
    ..Our data show that p90RSK activation inhibits Sentrin/SUMO- specific proteases 2 (SENP2) de-SUMOylation activity and increases both p53 and ERK5-SUMOylation, which increases p53 nuclear export and ..
  2. Yuan Chen; Fiscal Year: 2015
    ..In preliminary studies, we also identified a role of SENP1 and SENP2 in HIV replication...