SEMG2

Summary

Gene Symbol: SEMG2
Description: semenogelin II
Alias: SGII, semenogelin-2, Semenogelin 2
Species: human

Top Publications

  1. doi Aspects of the neuroendocrine cerebellum: expression of secretogranin II, chromogranin A and chromogranin B in mouse cerebellar unipolar brush cells
    M G Nunzi
    Department of Cell and Molecular Biology, The Feinberg School of Medicine of Northwestern University, Searle 5 474, 320 East Superior Street, Chicago, IL 60611, USA
    Neuroscience 162:673-87. 2009
  2. ncbi Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis
    H Sprott
    Center for Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Switzerland
    J Rheumatol 27:2347-50. 2000
  3. ncbi Characterization of semenogelin proteins in the human retina
    Vera L Bonilha
    Department of Ophthalmic Research, The Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Exp Eye Res 83:120-7. 2006
  4. ncbi Calcitonin gene-related peptide: possible role in formation and maintenance of neuromuscular junctions
    C Sala
    CNR Center of Cytopharmacology, University of Milano, Italy
    J Neurosci 15:520-8. 1995
  5. ncbi Granin proteins (chromogranin A and secretogranin II C23-3 and C26-3) in the intestine of reptiles
    T Trandaburu
    Department of Comparative Endocrinology, Institute of Biology, Bucharest, Romania
    Ann Anat 181:261-8. 1999
  6. ncbi Purification, pH-dependent conformational change, aggregation, and secretory granule membrane binding property of secretogranin II (chromogranin C)
    Hee Yun Park
    National Creative Research Initiative Center for Secretory Granule Research, Korea Advanced Institute of Science and Technology, Yu Sung Gu, Dae Jeon, Korea 305 701
    Biochemistry 41:1259-66. 2002
  7. ncbi GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum
    Wenxia Zhou
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Brain Res 1004:18-28. 2004
  8. ncbi Seasonal cyclicity of secretogranin-II expression and its modulation by sex steroids and GnRH in the female goldfish pituitary
    M Samia
    Department of Biology, University of Ottawa Centre for Advanced Research in Environmental Genomics CAREG, MacDonald Hall, Ottawa, Ont, Canada K1N 6N5
    Gen Comp Endocrinol 139:198-205. 2004
  9. ncbi Characterization of inter-genogroup reassortant rotavirus strains detected in hospitalized children in Italy
    Maria Cristina Medici
    Section of Microbiology, Department of Pathology and Laboratory Medicine, Medical School, University of Parma, Parma, Italy
    J Med Virol 79:1406-12. 2007
  10. doi Hominoid seminal protein evolution and ancestral mating behavior
    Sarah J Carnahan
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Am J Primatol 70:939-48. 2008

Research Grants

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. doi Aspects of the neuroendocrine cerebellum: expression of secretogranin II, chromogranin A and chromogranin B in mouse cerebellar unipolar brush cells
    M G Nunzi
    Department of Cell and Molecular Biology, The Feinberg School of Medicine of Northwestern University, Searle 5 474, 320 East Superior Street, Chicago, IL 60611, USA
    Neuroscience 162:673-87. 2009
    ..Here we show by immunocytochemistry that chromogranin A (CgA) chromogranin B (CgB) and secretogranin II (SgII), the principal granins situated in neuronal secretory granules and large dense-core vesicles, are widely but ..
  2. ncbi Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis
    H Sprott
    Center for Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Switzerland
    J Rheumatol 27:2347-50. 2000
    ..As secretogranin II (SGII) is the precursor of SN, we investigated expression of SGII mRNA and SN protein in the synovium of patients with ..
  3. ncbi Characterization of semenogelin proteins in the human retina
    Vera L Bonilha
    Department of Ophthalmic Research, The Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Exp Eye Res 83:120-7. 2006
    ..Western blots detected semenogelin I and II in both RPE and neural retina while the vitreous contained only SgII. Cryo and paraffin sections of human retina were processed for both immunofluorescence and DAB reaction with an ..
  4. ncbi Calcitonin gene-related peptide: possible role in formation and maintenance of neuromuscular junctions
    C Sala
    CNR Center of Cytopharmacology, University of Milano, Italy
    J Neurosci 15:520-8. 1995
    The expression and content of calcitonin gene-related peptide (CGRP) and secretogranin II (SgII) in adult rat motor neurons were examined by in situ hybridization, Northern blot analysis, and immunocytochemistry...
  5. ncbi Granin proteins (chromogranin A and secretogranin II C23-3 and C26-3) in the intestine of reptiles
    T Trandaburu
    Department of Comparative Endocrinology, Institute of Biology, Bucharest, Romania
    Ann Anat 181:261-8. 1999
    ..b>SgII-immunoreactivity--absent in turtle--revealed nerve cells and fibers, besides enteroendocrine cells in lizard and ..
  6. ncbi Purification, pH-dependent conformational change, aggregation, and secretory granule membrane binding property of secretogranin II (chromogranin C)
    Hee Yun Park
    National Creative Research Initiative Center for Secretory Granule Research, Korea Advanced Institute of Science and Technology, Yu Sung Gu, Dae Jeon, Korea 305 701
    Biochemistry 41:1259-66. 2002
    Secretogranin II (SgII) is one of the three major proteins, the other two being chromogranins A (CGA) and B (CGB), of secretory granules of neuroendocrine cells...
  7. ncbi GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum
    Wenxia Zhou
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Brain Res 1004:18-28. 2004
    ..to increase preprodynorphin (PPD), preprotachykinin (PPT), preproenkephalin (PPE), and secretogranin II (SGII) mRNA levels in the striatum without altering the basal levels of these signals...
  8. ncbi Seasonal cyclicity of secretogranin-II expression and its modulation by sex steroids and GnRH in the female goldfish pituitary
    M Samia
    Department of Biology, University of Ottawa Centre for Advanced Research in Environmental Genomics CAREG, MacDonald Hall, Ottawa, Ont, Canada K1N 6N5
    Gen Comp Endocrinol 139:198-205. 2004
    The secretory vesicle protein secretogranin-II (SgII), a precursor for the bioactive peptide secretoneurin, is expressed at all levels of the goldfish reproductive axis, including the hypothalamus, pituitary and ovaries...
  9. ncbi Characterization of inter-genogroup reassortant rotavirus strains detected in hospitalized children in Italy
    Maria Cristina Medici
    Section of Microbiology, Department of Pathology and Laboratory Medicine, Medical School, University of Parma, Parma, Italy
    J Med Virol 79:1406-12. 2007
    ..All the G1 strains with short e-type were subgroup (SG)II or SGI + SGII, and possessed a NSP4 of genogroup B or A + B...
  10. doi Hominoid seminal protein evolution and ancestral mating behavior
    Sarah J Carnahan
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Am J Primatol 70:939-48. 2008
    ..of the coding regions was also obtained for one eastern lowland gorilla at the semenogelin genes (SEMG1 and SEMG2), which code for the predominant proteins in semen...
  11. doi Silica gel modified with lumogallion for aluminum determination by spectroscopic methods
    Oksana Yu Nadzhafova
    Department of Analytical Chemistry, Taras Shevchenko University, 64 Volodymyrska Street, Kyiv, Ukraine
    Talanta 67:767-72. 2005
    ..For this purpose, silica modified with tridecyloctadecylammonium chloride(SGII) using adsorption technique and glass slide modified with thin silica-poly(dimethyldiallyl-ammonium chloride) (SGI) ..
  12. pmc Regulatory peptides from chromogranin A and secretogranin II
    Karen B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Mol Neurobiol 30:1145-6. 2010
    This commentary is focusing on novel aspects on the secreted CgA- and SgII-derived peptides, vasostatin-I (bovine and human CgA(1-76), VS-I), WE-14 (CgA(316-329)), catestatin (bovine CgA(344-366), human CgA(352-372), Cts) and the SgII-..
  13. doi Expression of semenogelins I and II and its prognostic significance in human prostate cancer
    Anastasia M Canacci
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Prostate 71:1108-14. 2011
    ..Little is known about the role of semenogelins, seminal plasma proteins that play critical roles in semen clotting and subsequent liquefaction in the presence of zinc and prostate-specific antigen, in human malignancies...
  14. ncbi The functional role of chromogranins in exocytosis
    Natalia Domínguez
    Unidad de Farmacologia, Universidad de La Laguna, 38071 La Laguna, Tenerife, Spain
    J Mol Neurosci 48:317-22. 2012
    ..Proteomic analysis confirmed the absence of CgA and B, and revealed small changes in SgII in the LDCV-enriched fraction, as well as the overexpression of fibrinogen and other proteins...
  15. doi Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population
    Virendra Singh
    1 National Institute of Pathology ICMR, New Delhi, India
    OMICS 19:688-99. 2015
    ..included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, ..
  16. ncbi The cAMP-response element mediates induction of secretogranin II by CHX and FSK in GH4C1 cells
    L C Jones
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile 36688, USA
    Am J Physiol 274:E656-64. 1998
    The effect of cAMP on secretogranin II (SgII) gene transcription in GH4C1 (GH) cells is not observed unless protein synthesis is inhibited...
  17. ncbi Involvement of multiple signaling pathways in PACAP-induced EM66 secretion from chromaffin cells
    Johann Guillemot
    INSERM U413, European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, University of Rouen, 76821 Mont Saint Aignan, France
    Regul Pept 137:79-88. 2006
    Secretoneurin (SN) and EM66 are two highly conserved peptides that derive from the processing of secretogranin II (SgII), one of the major constituents of chromaffin cell secretory vesicles...
  18. ncbi Expression and processing of the neuroendocrine protein secretogranin II in benign and malignant pheochromocytomas
    Johann Guillemot
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP23, University of Rouen, 76821 Mont Saint Aignan, and Department of Endocrinology, Hopital de Brabois, Nancy, France
    Ann N Y Acad Sci 1073:527-32. 2006
    The aim of the present study was to compare the expression levels of secretogranin II (SgII), prohormone convertases (PC)1 and PC2, and the proteolytic processing of SgII in benign versus malignant pheochromocytomas...
  19. doi Landscape epidemiology of bean pod mottle comovirus: molecular evidence of heterogeneous sources
    Jeffrey D Bradshaw
    Department of Entomology, Panhandle Research and Extension Center, University of Nebraska Lincoln, Scottsbluff, NE 69361, USA
    Arch Virol 156:1615-9. 2011
    Bean pod mottle virus (BPMV) RNAs are grouped into subgroups (sgI and sgII). A BPMV partial diploid reassortant (IA-Di1) from the perennial Desmodium illinoense contained both RNA1 subgroups and an RNA1 recombinant...
  20. pmc Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma
    Prashant Kumar
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, Singapore
    Oncotarget 6:13539-49. 2015
    ..4% and 100%; specificity, 100%) using the same methods. Thus, our multiplex biomarker panel offers unprecedented accuracy for the diagnosis of BCa patients and provides the prospect for a non-invasive way to detect bladder cancer. ..
  21. doi Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)
    M Mikwar
    Centre of Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, ON, Canada
    Peptides 78:42-50. 2016
    ..derived by proteolytic processing from the middle domain of the ∼600 amino acid precursor secretogranin-II (SgII)...
  22. ncbi Secretory granules and granins in hyperstimulated male rat gonadotropes
    T Watanabe
    Department of Anatomy, Hannover Medical School, Germany
    J Histochem Cytochem 41:1801-12. 1993
    ..of controls contained differently composed secretory granules: small granules showed immunoreactivity for LH and SgII and larger granules were immunoreactive for FSH and CgA and to a lesser extent, for LH...
  23. ncbi Synergistic action of upstream elements and a promoter-proximal CRE is required for neuroendocrine cell-specific expression and second-messenger regulation of the gene encoding the human secretory protein secretogranin II
    C Desmoucelles
    European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    Mol Cell Endocrinol 157:55-66. 1999
    Secretogranin II (SgII) is a secretory polypeptide stored in large dense core vesicles of neuroendocrine and neuronal cells...
  24. ncbi Orexin/hypocretin neurons: chemical phenotype and possible interactions with melanin-concentrating hormone neurons
    Laurence Bayer
    CNRS FRE 2174, Laboratoire d Histologie, Faculte de Medecine, Place Saint Jacques, 25030 Cedex, Besancon, France
    Regul Pept 104:33-9. 2002
    ..the codistributed melanin-concentrating hormone (MCH) neurons, express both dynorphin (DYN) and secretogranin II (SgII) genes...
  25. ncbi Secretoneurin stimulates goldfish pituitary luteinizing hormone production
    E Zhao
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ont, Canada K1N 6N5
    Neuropeptides 40:275-82. 2006
    Secretoneurin (SN), a 33-34 amino acid neuropeptide is derived from endoproteolysis of secretogranin II (SgII), a member protein of the chromogranin family...
  26. doi Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells
    L Li
    Cell Death and Human Disease Group, Division of Cancer and Developmental Cell Biology, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Republic of Singapore
    Cell Death Differ 15:879-88. 2008
    Identification of AP-1 target genes in apoptosis and differentiation has proved elusive. Secretogranin II (SgII) is a protein widely distributed in nervous and endocrine tissues, and abundant in neuroendocrine granules...
  27. pmc Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells
    E Zhao
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 301:E288-97. 2011
    Secretoneurin (SN) is a functional secretogranin II (SgII)-derived peptide that stimulates luteinizing hormone (LH) production and its release in the goldfish...
  28. doi Accuracy of single-shot autocorrelation measurements of petawatt laser pulses
    Xiaoping Ouyang
    Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, China
    Appl Opt 51:3989-94. 2012
    At the Shen Guang II (SGII) Petawatt Laser Facility, measurements of large-energy, single-shot laser pulses sometimes feature asymmetric autocorrelation signals, causing uncertainty in the measurement of compressed pulses...
  29. pmc Birth-and-Death of KLK3 and KLK2 in Primates: Evolution Driven by Reproductive Biology
    Patrícia Isabel Marques
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Genome Biol Evol 4:1331-8. 2012
    ..d(N)/d(S) ratios, and addressed the hypothesis of coevolution with their substrates, the semenogelins (SEMG1 and SEMG2)...
  30. doi Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells
    Maite Courel
    Inserm U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, 76821 Mont Saint Aignan, France Normandy University, Normandy, France
    Eur J Cancer 50:3039-49. 2014
    ..In this study, we investigated the expression of the neuroendocrine secretory protein secretogranin II (SgII) in PCa, and its potential involvement in the progression of this cancer as a granulogenic factor promoting NED.
  31. pmc Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo
    Suvi Lappalainen
    a Vaccine Research Center School of Medicine University of Tampere Tampere, Finland
    Hum Vaccin Immunother 10:2039-47. 2014
    ..were induced by immunizing BALB/c mice intranasally with a combination of recombinant RV VP6 protein (subgroup II [SGII]) and norovirus (NoV) virus-like particles (VLPs) used in a candidate vaccine...
  32. doi Co-storage and secretion of growth hormone and secretoneurin in retinal ganglion cells
    Carlos G Martínez-Moreno
    Department of Physiology, University of Alberta, Edmonton T6G 2H7, Canada
    Gen Comp Endocrinol 220:124-32. 2015
    ..this work we demonstrate for the first time that GH- and secretoneurin (SN) immunoreactivity (the secretogranin II (SgII) fragment) are similarly present in retinal ganglion cells (RGCs), which is an extrapituitary site of GH expression,..
  33. ncbi Evidence for independent segregation of the VP6- and NSP4- encoding genes in porcine group A rotavirus G6P[13] strains
    S Ghosh
    Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Arch Virol 152:423-9. 2007
    ..with a borderline P[13] genotype, and VP6 related to bovine and human SGI strains rather than porcine SGI and/or SGII group A rotaviruses. Both strains had NSP4 and NSP5 of porcine origin...
  34. ncbi Sexual selection and the adaptive evolution of mammalian ejaculate proteins
    Steven A Ramm
    Mammalian Behaviour and Evolution Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    Mol Biol Evol 25:207-19. 2008
    ..Using the same methods, we then reanalyzed previously published data on 2 primate genes, SEMG1 and SEMG2. Although SEMG2 also shows evidence of positive selection concentrated in lineages subject to high levels of sperm ..
  35. pmc Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells
    A S Dittie
    Imperial Cancer Research Fund, London, U K
    Biochem J 310:777-87. 1995
    To study the processing of secretogranin II (SgII) by the prohormone convertase PC2 we have generated a stable PC12 cell line which expresses mouse PC2...
  36. pmc Homotypic fusion of immature secretory granules during maturation in a cell-free assay
    S Urbé
    Secretory Pathways Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    J Cell Biol 143:1831-44. 1998
    ..homotypic fusion between one population of ISGs containing a [35S]sulfate-labeled substrate, secretogranin II (SgII), and a second population containing the prohormone convertase PC2...
  37. ncbi Partial characterization of a genomic island associated with the multidrug resistance region of Salmonella enterica Typhymurium DT104
    D A Boyd
    Bureau of Microbiology, Laboratory Centre for Disease Control, Health Canada, 1015 Arlington St, Winnipeg, Manitoba, Canada R3E 3R2
    FEMS Microbiol Lett 189:285-91. 2000
    ..The 43-kb fragment, here referred to as Salmonella genomic island I (SgiI), was found in the genome of S...
  38. pmc New ordered metastable phases between the gel and subgel phases in hydrated phospholipids
    B Tenchov
    Institute of Biophysics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biophys J 80:1873-90. 2001
    ..The PE and PC low-temperature phases denoted L(R1) and SGII, respectively, have different hydrocarbon chain packing...
  39. ncbi Promotion of intragranular co-aggregation with LH by enhancement of secretogranin II storage resulted in increased intracellular granule storage in gonadotrophs of GnRH-deprived male mice
    J L Crawford
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Old Dalkeith Road, UK
    Reproduction 124:267-77. 2002
    ..Secretogranin II (SgII) and CgA mRNA contents were not different between experimental groups...
  40. ncbi Neuroendocrine cell type-specific and inducible expression of chromogranin/secretogranin genes: crucial promoter motifs
    Sushil K Mahata
    Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92093 0838, USA
    Ann N Y Acad Sci 971:27-38. 2002
    ..In addition to CRE, GC-rich domains in chromogranin B (CgB) and serum response element (SRE) in secretogranin II (SgII) promoters appear to play important roles in neuroendocrine cell type-specific expression of CgB and SgII genes...
  41. ncbi Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB
    Seok Bean Song
    Department of Biochemistry, Institute of Biotechnology, Chungnam National University, Taejon 305 764, South Korea
    Mol Cell Endocrinol 199:29-36. 2003
    To investigate the events involved in regulation of the secretogranin II (SgII) gene, luciferase reporter constructs were transfected into gonadotrope-derived, alphaT3-1 cells...
  42. ncbi The chromogranins: their roles in secretion from neuroendocrine cells and as markers for neuroendocrine neoplasia
    Steven A Feldman
    Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, National Institutes of Health, Bethesda MD 20892 4090, USA
    Endocr Pathol 14:3-23. 2003
    ..The chromogranin family includes chromogranins A (CgA) and B (CgB) and secretogranin II (SgII, once called chromogranin C)...
  43. ncbi Biochemical characterization and immunocytochemical localization of EM66, a novel peptide derived from secretogranin II, in the rat pituitary and adrenal glands
    Maite Montero-Hadjadje
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    J Histochem Cytochem 51:1083-95. 2003
    Characterization of secretogranin II (SgII) mRNA in various vertebrates has revealed selective conservation of the amino acid sequences of two regions of the protein, i.e...
  44. pmc Eight-year survey of human rotavirus strains demonstrates circulation of unusual G and P types in Hungary
    Krisztian Banyai
    Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
    J Clin Microbiol 42:393-7. 2004
    ..Among these specimens, we identified both the four globally common strains (P[8],G1 subgroup II (sgII); P[4],G2 sgI; P[8],G3 sgII; and P[8],G4 sgII) and six uncommon strains (P[6],G4 sgII; P[9],G3 sgI; P[9],G6 sgI; P[..
  45. ncbi Manserin, a novel peptide from secretogranin II in the neuroendocrine system
    Aika Yajima
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neuroreport 15:1755-9. 2004
    ..Manserin is derived from secretogranin II (SgII), a member of granin acidic secretory protein family by proteolytic processing, as previously reported ..
  46. ncbi Intracerebral baclofen administration decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum
    Wenxia Zhou
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 30:880-90. 2005
    ..and neuropeptide (preprodynorphin (PPD), preprotachykinin (PPT), preproenkephalin (PPE), and secretogranin II (SGII)) mRNA expression in the striatum (Zhou et al, 2004)...
  47. ncbi The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects
    Karen B Helle
    Department of Biomedicine, Division of Physiology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Biol Rev Camb Philos Soc 79:769-94. 2004
    The chromogranins A (CgA) and B (CgB) and secretogranin II (SgII) constitute the main members of a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system...
  48. ncbi Differential expression and processing of chromogranin A and secretogranin II in relation to the secretory status of endocrine cells
    J R Peinado
    Department of Cell Biology, Physiology, and Immunology, Campus de Rabanales Edificio Severo Ochoa, Planta 3, University of Cordoba, E 14014 Cordoba, Spain
    Endocrinology 147:1408-18. 2006
    Chromogranin A (CgA) and secretogranin II (SgII) are neuroendocrine secretory proteins that participate in regulation of the secretory pathway and also serve as precursors of biologically active peptides...
  49. ncbi Proteolytic processing and differential distribution of secretogranin-II in goldfish
    E Zhao
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ont, Canada
    Gen Comp Endocrinol 146:100-7. 2006
    Secretoneurin (SN) is a 33-34 amino acid neuropeptide derived by endoproteolysis of secretogranin-II (SgII), a chromogranin...
  50. pmc Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells
    Malika Ahras
    Cancer Research UK, London Research Institute, London WC2A 3PX, England, UK
    J Cell Biol 173:241-51. 2006
    ..Furthermore, the Syt IV CD, as well as Syt IV depletion, reduces secretogranin II (SgII) processing by prohormone convertase 2 (PC2)...
  51. pmc 3', 5'-cyclic adenosine 5'-monophosphate response element-dependent transcriptional regulation of the secretogranin II gene promoter depends on gonadotropin-releasing hormone-induced mitogen-activated protein kinase activation and the transactivator activ
    Jianjun Xie
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Endocrinology 149:783-92. 2008
    Previous studies demonstrated that GnRH-induced secretogranin II (SgII) promoter regulation required a consensus cAMP response element (CRE) and protein kinase A/CRE binding protein...
  52. doi Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours
    Mats Stridsberg
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Regul Pept 148:95-8. 2008
    ..In this study we describe generation of antibodies against SgII, SgIII, SgV and the proconvertases PC1/3 and PC2 and development of radioimmunoassays for measurements of these ..
  53. doi Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system
    Karen B Helle
    Department of Biomedicine, Division of Physiology, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Results Probl Cell Differ 50:21-44. 2010
    Chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) belong to a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system...
  54. doi Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..soluble AbetaPP (sAbetaPPalpha), beta-cleaved soluble AbetaPP (sAbetaPPbeta), and peptides derived from CgB and SgII (Secretogranin-II, CgC)...
  55. doi Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II
    Guida Maria Portela-Gomes
    Department of Gastroenterology, University of Lisbon, Lisbon, Portugal
    Regul Pept 165:30-5. 2010
    ..SgIII has been recently reported in endocrine pancreas. The aim of the present study was to examine the expression of SgIII in different NETs and compare it with the expression of CgA, CgB and SgII epitopes.
  56. doi Granins and their derived peptides in normal and tumoral chromaffin tissue: Implications for the diagnosis and prognosis of pheochromocytoma
    Marlène Guérin
    Institut National de la Sante et de la Recherche Medicale INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, European Institute for Peptide Research IFRMP 23, University of Rouen, Mont Saint Aignan, France
    Regul Pept 165:21-9. 2010
    ..It appears that, except SgIII, all members of the granin family i.e. CgA, CgB, SgII, SgIV-SgVII and proSAAS, and most of their derived peptides are present in adrenomedullary chromaffin cells and in ..
  57. doi Quantitation of sudomotor innervation in skin biopsies of patients with diabetic neuropathy
    Kai Ren Luo
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Neuropathol Exp Neurol 70:930-8. 2011
    ..A computerized area-based morphometric analysis was used to quantify the sweat gland innervation index (SGII), defined as the area of nerve fibers normalized to the area of sweat glands...
  58. doi Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66
    J Guillemot
    Institut National de la Santé et de la Recherche Médicale Unité 982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Rouen University, Institute for Research and Innovation in Biomedicine, 76821 Mont Saint Aignan, France
    J Mol Endocrinol 48:115-27. 2012
    We have previously demonstrated that measurement of tissue concentrations of the secretogranin II (SgII or SCG2 as listed in the HUGO database)-derived peptide EM66 may help to discriminate between benign and malignant pheochromocytomas ..
  59. doi Rotavirus in diarrheal children in rural Burkina Faso: high prevalence of genotype G6P[6]
    Johan Nordgren
    Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Infect Genet Evol 12:1892-8. 2012
    ..It was the second most common constellation after G9P[8]SGII (32%); and followed by G1P[8]SGII (20%) and G2P[4]SGI (9%)...
  60. doi Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones
    Meng Sun
    Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Traffic 14:205-18. 2013
    ..ACTH)/POMC was still localized to some few remaining SGs together with another granin protein, secretogranin II (SgII), and was secreted in a regulated manner...
  61. pmc A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein
    Owen Kavanagh
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol Methods 189:228-31. 2013
    ..circulating rotavirus strains in each subgroup (SG) identified in a birth cohort of children in southern India [SGII (G1P[8]) and SGI (G10P[11])] were produced...
  62. pmc Reproduction and immunity-driven natural selection in the human WFDC locus
    Zélia Ferreira
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Biol Evol 30:938-50. 2013
    ..Neighboring SEMG genes encode seminal proteins Semenogelin 1 and 2 (SEMG1 and SEMG2)...
  63. doi CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain
    Tetsushi Sadakata
    Advanced Scientific Research Leaders Development Unit and Department of Molecular and Cellular Neurobiology, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan, Japan Science and Technology Agency Core Research for Evolutional Science and Technology, Kawaguchi, Saitama 332 0012, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo 160 8582, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278 8510, Japan, Graduate School of Medical Science, Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan, Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan, Laboratory for Behavioral Genetics, Funding Program for World Leading Innovative R and D on Science and Technology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan, Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan, and Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606 8507, Japan
    J Neurosci 33:17326-34. 2013
    ..Forebrain-specific Caps1 cKO mice showed reduced immunoreactivity for the DCV marker secretogranin II (SgII) and the trans-Golgi network (TGN) marker syntaxin 6, a reduced number of presynaptic DCVs, and dilated trans-Golgi ..
  64. doi Altered levels of fecal chromogranins and secretogranins in IBS: relevance for pathophysiology and symptoms?
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Am J Gastroenterol 107:440-7. 2012
    ..We therefore performed a hypothesis generating study to evaluate the association between fecal levels of CgA, CgB, SgII, and SgIII, with the clinical and pathophysiological phenotype of irritable bowel syndrome (IBS) patients.
  65. pmc Effect of glycemic control on sudomotor denervation in type 2 diabetes
    Kai Ren Luo
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Diabetes Care 35:612-6. 2012
    ..Sudomotor symptoms are a common component of diabetic autonomic neuropathy, but the pathology of sudomotor innervation and its relationship with glycemic control have remained obscured...
  66. pmc Emergence of unusual G6P[6] rotaviruses in children, Burkina Faso, 2009-2010
    Johan Nordgren
    Linkoping University, Linkoping, Sweden
    Emerg Infect Dis 18:589-97. 2012
    ..This emergence was related to a shift in the overall age of infected children; ROTAV SGII infected younger children and induced more severe symptoms...
  67. pmc Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties
    Helge Røsjø
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway
    PLoS ONE 7:e37401. 2012
    Several beneficial effects have been demonstrated for secretogranin II (SgII) in non-cardiac tissue...
  68. ncbi Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors
    A Pagani
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Diagn Mol Pathol 1:165-72. 1992
    ..Antibodies and probes specific for chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) were used. Ewing's sarcomas and PNETs, unlike neuroblastomas, were negative for CgA and CgB...
  69. ncbi Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells
    A M Giudici
    Department of Medical Pharmacology, University of Milano, Italy
    Eur J Cell Biol 58:383-9. 1992
    ..into the expression of the known markers of secretory neuroendocrine dense core organelles, secretogranin II (SgII), chromogranin A (CgA), and chromogranin B (CgB) during neuronal differentiation, the immunolocalization of these ..
  70. pmc Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein
    H Lilja
    Department of Clinical Chemistry, Lund University, Malmo General Hospital, Sweden
    Proc Natl Acad Sci U S A 89:4559-63. 1992
    ..This cDNA cross-hybridizes to a larger transcript coding for a second secretory protein, SgII. Here we report the almost complete structure of a precursor of SgII established by lambda gt11 clones isolated ..
  71. ncbi [Isolation and structure determination of two peptides occurring in human seminal plasma]
    K Schneider
    Lehrstuhl fur Organische Chemie I der Universitat Bayreuth
    Biol Chem Hoppe Seyler 370:353-6. 1989
    ..Their structures were determined by gas-phase sequencing simultaneously considering the different peak intensities...
  72. ncbi Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas
    R V Lloyd
    Department of Pathology, University of Michigan, Ann Arbor
    Diagn Mol Pathol 3:38-45. 1994
    ..CgB, SgII, SgIII, and SgV mRNA transcripts were present in most adenomas, and SgIV protein was detected in all groups of ..
  73. ncbi Regulation of expression of secretogranin II mRNA in female rat pituitary and hypothalamus
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama, Birmingham 35294
    Neuroendocrinology 57:422-31. 1993
    Secretogranin II (SgII) is an acidic 86-kD protein which is synthesized by most neuroendocrine cells but occurs in greatest abundance in the anterior pituitary gland where it is localized primarily in gonadotrophs...
  74. ncbi The neuroendocrine proteins secretogranin II and III are regionally conserved and coordinately expressed with proopiomelanocortin in Xenopus intermediate pituitary
    J C Holthuis
    Department of Animal Physiology, University of Nijmegen, The Netherlands
    J Neurochem 66:2248-56. 1996
    ..and secretion, we have isolated cDNA clones encoding the first nonmammalian homologues of secretogranin II (SgII) and secretogranin III (SgIII) from a Xenopus intermediate pituitary cDNA library...
  75. ncbi The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA
    A Lundwall
    Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden
    Eur J Biochem 235:466-70. 1996
    ..A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, ..
  76. ncbi Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor
    H Kise
    Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Japan
    Eur J Biochem 238:88-96. 1996
    ....
  77. ncbi Secretogranin II: regulation of synthesis and post-translational proteolysis in bovine adrenal chromaffin cells
    D Soszynski
    Unité INSERM U 338 Biologie de la Communication Cellulaire, Strasbourg, France
    J Neuroendocrinol 5:655-62. 1993
    Secretogranin II (SgII), also called chromogranin C, is an acidic tyrosine-sulfated secretory protein found in secretory granules in a wide variety of endocrine cells and neurones...
  78. ncbi Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry
    A Bjartell
    Department of Urology, University Hospital, Malmo, Sweden
    J Androl 17:17-26. 1996
    ....
  79. ncbi Secretogranin II (SgII) distribution and processing studies in human normal and adenomatous anterior pituitaries using new polyclonal antibodies
    V S Vallet
    C N R S U R A 256 Biologie Cellulaire et Reproduction, Universite de Rennes I, France
    Regul Pept 68:155-63. 1997
    Studies concerning the identification of Secretogranin II (SgII) and its processed forms in human pituitary remain scarce since no anti-human SgII antisera has been available...
  80. ncbi Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase
    A Peter
    Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
    Eur J Biochem 252:216-21. 1998
    ..We also found that PSA was unable to release any semenogelin fragments during exposure of the high molecular-mass complexes of cross-linked semenogelin to active PSA...
  81. ncbi Effects of sex steroids on secretory granule formation in gonadotropes of castrated male rats with respect to granin expression
    T Watanabe
    Department of Cell Biology and Anatomy I, Osaka University Medical School, Japan
    Endocrinology 139:2765-73. 1998
    ..both large granules, which contain chromogranin A (CgA), and small granules, which contain secretogranin II (SgII)...
  82. ncbi Identification of a novel secretogranin II-derived peptide (SgII(187-252)) in adult and fetal human adrenal glands using antibodies raised against the human recombinant peptide
    Y Anouar
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA Centre National de la Recherche Scientifique, University of Rouen, Mount Saint Aignan, France
    J Clin Endocrinol Metab 83:2944-51. 1998
    Molecular cloning of secretogranin II (SgII) in phylogenetically distant species has recently revealed the existence of a highly conserved 66-amino acid peptide flanked by preserved pairs of basic residues...
  83. ncbi Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors
    J Lovgren
    Department of Laboratory Medicine, Lund University, Malmo, Sweden
    Eur J Biochem 262:781-9. 1999
    ..This regulation may be impaired in CAP and advanced metastatic cancer resulting in lack of control of the hK2 activity and a need for other means of control...
  84. ncbi Isolation and characterization of the human secretogranin II gene promoter
    J G Scammell
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, USA
    Brain Res Mol Brain Res 75:8-15. 2000
    The goal of this study was to isolate and functionally characterize the human secretogranin II (SgII) gene promoter. SgII is a member of the granin family of proteins which are selectively expressed in neurosecretory cells...
  85. ncbi Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor
    J Malm
    Section for Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital Malmo, Malmo, Sweden
    Prostate 45:132-9. 2000
    ..In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa. We characterized the substrate specificity and zinc-mediated inhibition of PSA...
  86. ncbi Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats
    S Umemura
    Department of Pathology, Tokai University School of Medicine, Isehara, Japan
    Pathol Int 51:667-70. 2001
    ..We examined CgA, SgI and SgII mRNA expression by reverse transcription-polymerase chain reaction in rat mammary adenocarcinoma and fibroadenoma ..
  87. ncbi Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues
    Ake Lundwall
    Department of Laboratory Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    Mol Hum Reprod 8:805-10. 2002
    Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen...
  88. ncbi Influence of steroids and GnRH on biosynthesis and secretion of secretogranin II and chromogranin A in relation to LH release in LbetaT2 gonadotroph cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    J Endocrinol 174:473-83. 2002
    The granin proteins secretogranin II (SgII) and chromogranin A (CgA) are commonly found associated with LH and/or FSH within specialised secretory granules in gonadotroph cells, and it is possible that they play an important role in the ..
  89. ncbi A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulum
    Ake Lundwall
    Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
    Mol Hum Reprod 9:345-50. 2003
    ..consists of high molecular mass complexes of the seminal vesicle secreted semenogelin I (SgI) and semenogelin II (SgII)...
  90. pmc Evidence for genetic linkage between the gene segments encoding NSP4 and VP6 proteins in common and reassortant human rotavirus strains
    Miren Iturriza-Gomara
    Enteric Virus Unit, Enteric, Respiratory and Neurological Virus Laboratory, Health Protection Agency, London, United Kingdom
    J Clin Microbiol 41:3566-73. 2003
    ..was 100%, NSP4 genotype A being linked to VP6 of subgroup I (SGI) and NSP4 of genotype B being linked to VP6 of SGII. The diversity among the NSP4- and VP6-encoding genes was significantly less than that among the VP7 and VP4 genes ..
  91. ncbi Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma
    Kaoru Yoshida
    Department of Urology, St Marianna University School of Medicine, Kawasaki, Japan
    J Androl 24:878-84. 2003
    ..793, P <.0001). This result supports that SPMI, one of the fragments of Sg, has its inhibitory effect on ejaculated spermatozoa in liquefied semen under physiological conditions...
  92. ncbi Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen
    Michael I Jensen-Seaman
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    J Mol Evol 57:261-70. 2003
    ..Here we examine the molecular evolution of the semenogelin genes (SEMG1 and SEMG2), which code for the predominant structural proteins in human semen...
  93. ncbi The differential secretion of FSH and LH: regulation through genes, feedback and packaging
    A S McNeilly
    MRC Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Chancellor s Building, New Royal Infirmary, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reprod Suppl 61:463-76. 2003
    ..Secretogranin II (SgII) is associated with LH in these electron-dense storage granules and LH-SgII granules appear to be the principal ..
  94. ncbi No evidence for pituitary priming to gonadotropin-releasing hormone in relation to luteinizing hormone (LH) secretion prior to the preovulatory LH surge in ewes
    J L Crawford
    Human Reproductive Sciences Unit, Medical Research Council, University of Edinburgh Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    Biol Reprod 71:224-35. 2004
    ..Fewer LH(+ve)/secretogranin II(-ve) (SgII(-ve)) granules were present in gonadotropes of Foll ewes, coincident with increased basal LH levels...
  95. ncbi Differential secretion of gonadotrophins: investigation of the role of secretogranin II and chromogranin A in the release of LH and FSH in LbetaT2 cells
    L Nicol
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    J Mol Endocrinol 32:467-80. 2004
    This study investigated the role of the secretory granule proteins, secretogranin II (SgII) and chromogranin A (CgA), in the differential secretion of FSH and LH from LbetaT2 mouse gonadotroph cells...
  96. ncbi Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
    Steve Dorus
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 36:1326-9. 2004
    ..Specifically, we show that the evolution of SEMG2, the gene encoding semenogelin II, a main structural component of semen coagulum, is accelerated in polyandrous ..
  97. ncbi Ejaculates from the common marmoset (Callithrix jacchus) contain semenogelin and beta-microseminoprotein but not prostate-specific antigen
    Camilla Valtonen-Andre
    Wallenberg Laboratory, Department of Laboratory Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Mol Reprod Dev 71:247-55. 2005
    ..PAP), prostate-specific antigen (PSA), beta-microseminoprotein (MSP), semenogelin I (SgI), and semenogelin II (SgII), whereas only PAP and MSP are present in rodents...
  98. ncbi PACAP stimulates the release of the secretogranin II-derived peptide EM66 from chromaffin cells
    Johann Guillemot
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP23, University of Rouen, 76821 Mont Saint Aignan, France
    Ann N Y Acad Sci 1070:309-12. 2006
    The aim of the present article was to examine the effect of PACAP on the release of the SgII-derived peptide EM66 from primary cultures of bovine chromaffin cells...
  99. ncbi Development of novel tools for the diagnosis and prognosis of pheochromocytoma using peptide marker immunoassay and gene expression profiling approaches
    Youssef Anouar
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP23, University of Rouen, and Department of Genetics, Hopital Europeen Georges Pompidou, Paris, France
    Ann N Y Acad Sci 1073:533-40. 2006
    ..validated several assays for the measurement of peptides derived from chromogranin A (CgA) and secretogranin II (SgII) in order to determine whether these secreted neuroendocrine products could provide useful, complementary markers ..
  100. pmc Rotavirus VP7, VP4 and VP6 genotypes co-circulating in Tehran, Iran, between 2003 and 2004
    F Farahtaj
    WHO Collaborating Centre for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
    Epidemiol Infect 135:834-8. 2007
    ..In this study, both common and uncommon rotavirus genotypes were detected. The most prevalent types were G1P[8], SGII (59.2%) followed by G9P[8] SGII (15.5%) which has not been previously reported from Iran...
  101. ncbi The common marmoset (Callithrix jacchus) has two very similar semenogelin genes as the result of gene conversion
    Camilla Valtonen-Andre
    University Hospital MAS, Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, S 205 02 Malmo, Sweden
    Biol Reprod 76:604-10. 2007
    ..In primates, these seminal vesicle-secreted proteins are known as semenogelin I (SEMG1) and semenogelin II (SEMG2)...

Research Grants2

  1. Sympathetic Outflow to Catecholamine Storage Vesicles
    DANIEL O CONNOR; Fiscal Year: 2006
    ..The chromogranins/secretogranins (chromogranin A [Cga]. Chromogranin B [Cgb]. And secretogranin II [SgII], are a family of acidic proteins found in cores of amine and peptide hormone and neurotransmitter secretory ..
  2. Chromaffin Cell physiology: Novel molecular approaches
    Sushil Mahata; Fiscal Year: 2009
    ..These studies, utilizing unique knockout, transgenic, and human variants of catestatin, are likely to establish novel catestatin mechanisms in the development of hypertension and its modulation through nicotinic-cholinergic receptors. ..