SEMA6D

Summary

Gene Symbol: SEMA6D
Description: semaphorin 6D
Alias: semaphorin-6D, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Species: human

Top Publications

  1. ncbi Identification, characterization, and functional study of the two novel human members of the semaphorin gene family
    Xianghu Qu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing
    J Biol Chem 277:35574-85. 2002
  2. pmc Expression of semaphorin 6D and its receptor plexin-A1 in gastric cancer and their association with tumor angiogenesis
    Yanjie Lu
    Department of Pathology, Chengde Medical College, Chengde, Hebei 067000, P R China Cancer Research Laboratory, Chengde Medical College, Chengde, Hebei 067000, P R China
    Oncol Lett 12:3967-3974. 2016
  3. doi A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity
    Gillian C Barnett
    Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, UK University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Electronic address
    Radiother Oncol 111:178-85. 2014
  4. pmc Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics
    David Della-Morte
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States Department of Systems Medicine, School of Medicine, University of Tor Vergata Rome, Italy IRCCS San Raffaele Pisana, Rome, Italy
    J Neurol Sci 344:27-31. 2014
  5. doi Gene Signatures of 1,25-Dihydroxyvitamin D3 Exposure in Normal and Transformed Mammary Cells
    Katrina M Simmons
    University at Albany Cancer Research Center, Biomedical Sciences, University at Albany, Rensselaer, New York, 12144
    J Cell Biochem 116:1693-711. 2015
  6. pmc A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
    Branden S Moriarity
    1 Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA 2 Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA 3 Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Genet 47:615-24. 2015
  7. pmc RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens
    Nuri A Temiz
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genome Res 26:119-29. 2016
  8. pmc Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
    Hans Juergen Schulten
    Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
    PLoS ONE 11:e0153681. 2016
  9. pmc Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor, Michigan Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Mol Cancer Res 14:941-952. 2016
  10. ncbi Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
    Yin Peng
    Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cardiovasc Res . 2016

Research Grants

  1. Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling
    Yutaka Yoshida; Fiscal Year: 2013
  2. Kai Jiao; Fiscal Year: 2014
  3. Jenny P Ting; Fiscal Year: 2016
  4. Carol A Mason; Fiscal Year: 2016
  5. Carol A Mason; Fiscal Year: 2016
  6. Plexin-A1: Regulation by CIITA and immunologic function
    Jenny Ting; Fiscal Year: 2007

Scientific Experts

  • Gillian C Barnett
  • Vesna Boraska
  • Zhigang He
  • Masahiko Taniguchi
  • Hiroshi Watarai
  • Yutaka Yoshida
  • Masaru Katoh
  • BRIAN P O'CONNOR
  • Alfonso Catalano
  • Giovanni Stevanin
  • Taroh Kinoshita
  • Olivier Mauti
  • Renee P Stokowski
  • Carol A Mason
  • Kai Jiao
  • Noriko Takegahara
  • Atsushi Kumanogoh
  • Jenny Ting
  • Jenny P Ting
  • Toshihiko Toyofuku
  • Nuri A Temiz
  • Branden S Moriarity
  • Hitoshi Kikutani
  • Hyota Takamatsu
  • Yanjie Lu
  • Heather M Walline
  • Yin Peng
  • Hans Juergen Schulten
  • Aaron L Sarver
  • Natalie K Wolf
  • David A Largaespada
  • Katrina M Simmons
  • David Della-Morte
  • Ryota L Matsuoka
  • Takaaki Kuwajima
  • A Gulhan Ercan-Sencicek
  • Qian Xu
  • Jennifer R Leslie
  • Roland H Friedel
  • Anne Weissbach
  • Donald E Riley
  • Tatsusada Okuno
  • Masayuki Mizui
  • Tohru Tsujimura
  • Yuji Nakatsuji
  • Masafumi Kimura
  • Xiang Yang Zhao
  • Noriyuki Takahashi
  • Masanori Yabuki
  • Hong Zhang
  • Masatsugu Hori
  • Francis P Worden
  • Yatao Hu
  • Fatima Al-Adwani
  • Ding Li
  • Adeel Chaudhary
  • Gregory T Wolf
  • Emily L Bellile
  • Bingruo Wu
  • Jonathan B McHugh
  • Thomas E Carey
  • Yuhong Li
  • Mona Al-Sharif
  • Carol R Bradford
  • Adam J Dupuy
  • Qin Wang
  • Saleh S Baeesa
  • Lizhong Wang
  • Yanzhen Zuo
  • Jaudah Al-Maghrabi
  • Fahad Al-Ghamdi
  • Awatif Jamal
  • Lei Chen
  • Xiangyang Zhao
  • Mohammed Al-Qahtani
  • Jianbo Wang
  • ROBERT KESTERSON
  • Christine M Komarck
  • Sajjad Karim
  • Shaochen Liu
  • Deema Hussein
  • Lanying Song
  • Gregg Rokosh
  • Erin L McKean
  • Mark E Prince
  • Mohammed Bangash
  • Xiaoru Li
  • Jesse D Riordan
  • J Chad Brenner
  • Douglas B Chepeha

Detail Information

Publications36

  1. ncbi Identification, characterization, and functional study of the two novel human members of the semaphorin gene family
    Xianghu Qu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing
    J Biol Chem 277:35574-85. 2002
    We cloned two novel human transmembrane semaphorins, (HSA)SEMA6C and (HSA)SEMA6D, that belong to the class VI subgroup of the semaphorin family. The genes for SEMA6C and SEMA6D are mapped on chromosome 1q12-21.1 and 15q21.1, respectively...
  2. pmc Expression of semaphorin 6D and its receptor plexin-A1 in gastric cancer and their association with tumor angiogenesis
    Yanjie Lu
    Department of Pathology, Chengde Medical College, Chengde, Hebei 067000, P R China Cancer Research Laboratory, Chengde Medical College, Chengde, Hebei 067000, P R China
    Oncol Lett 12:3967-3974. 2016
    ..In the present study, semaphorin 6D (Sema6D) and its receptor plexin-A1 were identified to be expressed at high levels in vascular epithelial ..
  3. doi A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity
    Gillian C Barnett
    Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, UK University of Cambridge, Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, UK Electronic address
    Radiother Oncol 111:178-85. 2014
    ..This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity 2years after radiotherapy...
  4. pmc Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics
    David Della-Morte
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, United States Department of Systems Medicine, School of Medicine, University of Tor Vergata Rome, Italy IRCCS San Raffaele Pisana, Rome, Italy
    J Neurol Sci 344:27-31. 2014
    ..A genome-wide scan was performed for smoking×single nucleotide polymorphism (SNP) interactions on carotid plaque burden (CPB) to identify the potential genetic moderators in Hispanics...
  5. doi Gene Signatures of 1,25-Dihydroxyvitamin D3 Exposure in Normal and Transformed Mammary Cells
    Katrina M Simmons
    University at Albany Cancer Research Center, Biomedical Sciences, University at Albany, Rensselaer, New York, 12144
    J Cell Biochem 116:1693-711. 2015
    ..Regulation of a subset of immune (CD14, IL1RL1, MALL, CAMP, SEMA6D, TREM1, CSF1, IL33, TLR4) and metabolic (ITGB3, SLC1A1, G6PD, GLUL, HIF1A, KDR, BIRC3) genes by 1,25D was ..
  6. pmc A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
    Branden S Moriarity
    1 Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA 2 Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA 3 Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Nat Genet 47:615-24. 2015
    ..Lastly, we identified several oncogenes involved in axon guidance, including Sema4d and Sema6d, which we functionally validated as oncogenes in human osteosarcoma.
  7. pmc RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens
    Nuri A Temiz
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genome Res 26:119-29. 2016
    ..RNA fusion-based CISs were identified corresponding to both DNA-based CISs (Cdkn2a, Mycl1, Nf2, Pten, Sema6d, and Rere) and additional regions strongly associated with cancer that were not observed by LM-PCR (Myc, Akt1, Pth,..
  8. pmc Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
    Hans Juergen Schulten
    Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
    PLoS ONE 11:e0153681. 2016
    ..domain containing 1 (PID1), sema domain, transmembrane domain (TM) and cytoplasmic domain, (semaphorin) 6D (SEMA6D), and indolethylamine N-methyltransferase (INMT)...
  9. pmc Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor, Michigan Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Mol Cancer Res 14:941-952. 2016
    ..HPV integration patterns into cancer-associated genes, including TNFRSF13B, SCN2A, SH2B1, UBE2V2, SMOC1, NFIA, and SEMA6D Disrupted cellular transcripts were identified in the region of integration in four of the seven affected genes.
  10. ncbi Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
    Yin Peng
    Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cardiovasc Res . 2016
    ..The major goal of this study is to identify the critical downstream regulatory targets of BMP signalling in AV cushions, which are precursors of the AV septum and valves...
  11. pmc Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development
    Ryota L Matsuoka
    Howard Hughes Medical Institute, The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e63207. 2013
    ..Here, we investigate the physiological roles of three Class 6 transmembrane semaphorins (Sema6B, Sema6C, and Sema6D), previously identified as PlexA receptor ligands in non-retinal tissues, in mammalian retinal development...
  12. pmc Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits
    Vesna Boraska
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Am J Med Genet B Neuropsychiatr Genet 159:803-11. 2012
    ..Our study indicates that larger-scale collaborative studies will be needed to achieve the necessary power to detect loci underlying ED-related traits...
  13. pmc Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing
    Takaaki Kuwajima
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Neuron 74:676-90. 2012
    ..Here, we identify a tripartite molecular system for contralateral RGC projections: Semaphorin6D (Sema6D) and Nr-CAM are expressed on midline radial glia and Plexin-A1 on chiasm neurons, and Plexin-A1 and Nr-CAM are ..
  14. pmc A balanced t(10;15) translocation in a male patient with developmental language disorder
    A Gulhan Ercan-Sencicek
    Yale University, New Haven, CT 06519, USA
    Eur J Med Genet 55:128-31. 2012
    ..1 and 10q24.1 to refine the location of the breakpoints. The breakpoint on 15q21.1 interrupts the SEMA6D gene and the breakpoint on 10q24.1 is located between the ENTPD1 and CCNJ genes...
  15. pmc UTR dinucleotide simple sequence repeat evolution exhibits recurring patterns including regulatory sequence motif replacements
    Donald E Riley
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Gene 429:80-6. 2009
    ..The Sema6D gene's (GT)n was also well conserved among mammals examined...
  16. pmc Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation
    Jennifer R Leslie
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 138:4085-95. 2011
    ..Here we show that a mouse null mutation of Sema6d results in ectopic placement of the shafts of proprioceptive axons and their associated oligodendrocytes in the ..
  17. doi Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15
    Anne Weissbach
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck, Germany
    Mov Disord 25:1577-82. 2010
    ..In addition, we excluded alterations in two candidate genes in the linked region, namely expansion of a polyglutamine-coding CAG repeat in ARID3B and mutations in SEMA6D.
  18. pmc Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II
    Hyota Takamatsu
    Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Nat Immunol 11:594-600. 2010
    ..Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at ..
  19. doi The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells
    Alfonso Catalano
    Department of Molecular Pathology and Innovative Therapies, Marche University, Ancona, Italy
    Cancer Res 69:1485-93. 2009
    ..Here, we show that in asbestos-related malignant pleural mesothelioma (MPM), Semaphorin-6D (Sema6D) and its receptor plexin-A1 are frequently expressed and trigger a prosurvival program that promotes anchorage-..
  20. pmc PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord
    Yutaka Yoshida
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 52:775-88. 2006
    ..PlexinA1 is a proprioceptive sensory axon-specific receptor for sema6C and sema6D, which are expressed in a dynamic pattern in the dorsal horn...
  21. ncbi Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system
    Zhigang He
    1Division of Neuroscience, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2002:re1. 2002
    ..Thus, semaphorins may serve as important probes for exploring the mechanisms of intercellular communication during the development and function of the nervous system...
  22. ncbi Characterization of a novel member of murine semaphorin family
    Masahiko Taniguchi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 314:242-8. 2004
    ..Here we report murine orthologues of a novel member of class 6 semaphorin gene, semaphorin 6D (Sema6D), mapped on the chromosome 2...
  23. pmc Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2
    Toshihiko Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Dev 18:435-47. 2004
    ..Here, we demonstrate a critical involvement of Sema6D in cardiac morphogenesis...
  24. ncbi Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling
    Toshihiko Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 6:1204-11. 2004
    ..Through ligation of the Plexin-A1 receptor, the transmembrane-type semaphorin Sema6D regulates endocardial cell migration...
  25. ncbi Systematic screening for genes specifically expressed in the anterior neuroectoderm during early Xenopus development
    Noriyuki Takahashi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Int J Dev Biol 49:939-51. 2005
    ..We determined the entire coding regions of p54nrb, Semaphorin 6D and a novel gene designated scribble-related protein 1 (SCRP1)...
  26. ncbi Spastic paraplegia with thin corpus callosum: description of 20 new families, refinement of the SPG11 locus, candidate gene analysis and evidence of genetic heterogeneity
    Giovanni Stevanin
    INSERM U679, Salpetriere Hospital, 47 Boulevard de l Hopital, 75013 Paris, France
    Neurogenetics 7:149-56. 2006
    ..allowed significant refinement to 6 cM, of the minimal chromosomal interval, but analysis of two genes (MAP1A and SEMA6D) in this region did not identify causative mutations...
  27. ncbi Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
    Noriko Takegahara
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 8:615-22. 2006
    ..whereas plexin-A1 has multiple functions in chick cardiogenesis as a receptor for the transmembrane semaphorin, Sema6D, independent of neuropilins...
  28. pmc Expression of semaphorin 6D in gastric carcinoma and its significance
    Xiang Yang Zhao
    Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China
    World J Gastroenterol 12:7388-90. 2006
    To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.
  29. ncbi Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis
    T Kinoshita
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, 565 0871, Osaka, Japan
    Curr Opin Chem Biol 4:632-8. 2000
    ..These studies have revealed the common and also different characteristics of glycosylphosphatidyl-inositol biosynthesis enzymes in different organisms, leading to the development of species-specific inhibitors of the pathway...
  30. ncbi Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 20:405-9. 2007
    ..ROR1, ROR2, RYK, CELSR1, CELSR2, CELSR3, VANGL1, VANGL2, PRICKLE1, PRICKLE2, PTK7, SEMA6A, SEMA6B, SEMA6C and SEMA6D were carried out...
  31. ncbi Identification and characterization of zebrafish semaphorin 6D
    Masafumi Kimura
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 363:762-8. 2007
    ..Here, we report cloning and characterization of zebrafish transmembrane semaphorin gene, semaphorin 6D (sema6D)...
  32. pmc Semaphorin6A acts as a gate keeper between the central and the peripheral nervous system
    Olivier Mauti
    Developmental Neuroscience, Institute of Zoology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Neural Dev 2:28. 2007
    ..Based on its very restricted expression in boundary cap cells, we tested for a role of Sema6A as a gate keeper between the CNS and the PNS...
  33. pmc PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon
    Hiroshi Watarai
    Laboratories for Immune Regulation and Host Defense, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 105:2993-8. 2008
    ..However, when coupled with Sema6D, a ligand for Plexin-A1, limited TLR-stimulation resulted in PDC-TREM-mediated DAP12-dependent phosphorylation of ..
  34. doi The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function
    BRIAN P O'CONNOR
    Department of Microbiology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill CB7295, Chapel Hill, NC 27599, USA
    Immunol Res 41:217-22. 2008
    ..In this review, we describe contributions from our lab elucidating Plexin-A1 regulation of the immune system and our more recent findings of Semaphorin 6D regulation of T-cell immunity.
  35. pmc Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses
    BRIAN P O'CONNOR
    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:13015-20. 2008
    ..In this work, we examined the regulation of T cells by semaphorin 6D. Both in vitro and in vivo T cell stimulation enhanced semaphorin 6D expression...
  36. pmc A genomewide association study of skin pigmentation in a South Asian population
    Renee P Stokowski
    Perlegen Sciences, Mountain View, CA 94043, USA
    Am J Hum Genet 81:1119-32. 2007
    ..Our study is the first to interrogate polymorphisms across the genome, to find genetic determinants of the natural variation of skin pigmentation within a human population...

Research Grants6

  1. Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling
    Yutaka Yoshida; Fiscal Year: 2013
    ..Second, sema6D and its receptor plexinA1 are expressed by motor and proprioceptive sensory neurons when synaptogenesis is ..
  2. Kai Jiao; Fiscal Year: 2014
    ..Using this unique cell culture system, we identified Sema6D as a novel regulatory target of BMP signaling in AV cushions...
  3. Jenny P Ting; Fiscal Year: 2016
    ..and PIxnAI on DC represent a pair of ligand-receptor, and the T cell signaling pathway that is activated upon Sema6D engagement is conducted via the c-abl/CrL pathway...
  4. Carol A Mason; Fiscal Year: 2016
    ..semaphorin receptor Plexin-A1, expressed by contralateral RGCs and optic chiasm cells, form a complex with midline Sema6D to convert inhibition into growth of contralateral RGC axons...
  5. Carol A Mason; Fiscal Year: 2016
    ..In addition, we localized Sema6D at the chiasm midline and its receptor, Plexin-A1, is expressed in all crossing RGCs...
  6. Plexin-A1: Regulation by CIITA and immunologic function
    Jenny Ting; Fiscal Year: 2007
    ..Additional data suggest that Semaphorin 6D (SemaGD) is a candidate T cell ligand for Plxnal on DC...