SEMA3D

Summary

Gene Symbol: SEMA3D
Description: semaphorin 3D
Alias: Sema-Z2, coll-2, semaphorin-3D, collapsin 2, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Species: human

Top Publications

  1. pmc Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?
    L Karayan-Tapon
    Universite de Poitiers, EA 3805, CHU de Poitiers, 2 rue de la Miletrie, BP 577, Poitiers F 86021, France
    Br J Cancer 99:1153-60. 2008
  2. pmc Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease
    Carmen Martín-Sierra
    Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO Centre for Genomics and Oncological Research Pfizer University of Granada Junta de Andalucía, PTS, Granada, Spain
    Eur J Hum Genet 25:200-207. 2017
  3. doi In vivo analysis of Arg-Gly-Asp sequence/integrin α5β1-mediated signal involvement in embryonic enchondral ossification by exo utero development system
    Takayuki Inoue
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Shimane, Japan
    J Bone Miner Res 29:1554-63. 2014
  4. pmc Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells
    Boaz Kigel
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 3:e3287. 2008
  5. pmc Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton
    Jayalakshmi Govindan
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 9:e88574. 2014
  6. pmc Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression
    Marija Orlic-Milacic
    Molecular Neuropsychiatry and Development Lab, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    PLoS ONE 9:e91742. 2014
  7. pmc Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways
    Haig Aghajanian
    From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Biol Chem 289:17971-9. 2014
  8. doi Disruption of the SEMA3D gene in a patient with congenital heart defects
    Marta Sanchez-Castro
    INSERM, UMR1087, l institut du thorax, Nantes, France Université de NANTES, Nantes, France
    Hum Mutat 36:30-3. 2015
  9. doi Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
    Zheng Hu
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Nat Genet 47:158-63. 2015
  10. pmc Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability
    Qian Jiang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China
    Am J Hum Genet 96:581-96. 2015

Research Grants

  1. Determining the role of sema3d during fin regeneration
    MARY KATHRYN IOVINE; Fiscal Year: 2013
  2. Karl Degenhardt; Fiscal Year: 2014
  3. Jonathan A Epstein; Fiscal Year: 2016
  4. Lei Zheng; Fiscal Year: 2016
  5. Role of Semaphorins in axonal guidance
    JOHN KUWADA; Fiscal Year: 2005
  6. Molecular mechanisms guiding axon fasciculation
    MARC WOLMAN; Fiscal Year: 2006
  7. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
  8. Expression and regulation of the axon guidance cues
    Zheng Zheng Bao; Fiscal Year: 2009

Scientific Experts

  • R Ramonda
  • Alun Hughes
  • Yves E Henrotin
  • Thomas E Lallier
  • Gustav Lehne
  • J Ph Lejeune
  • B Stadlinger
  • Anne Pascale Meert
  • Hideomi Tanaka
  • Zheng Zheng Bao
  • Jonathan A Epstein
  • Karl Degenhardt
  • Lei Zheng
  • Haig Aghajanian
  • MARC WOLMAN
  • Jayalakshmi Govindan
  • MICHAEL BARRESI
  • MARY KATHRYN IOVINE
  • JOHN KUWADA
  • Qian Jiang
  • Mary C Halloran
  • Kaoru Takahashi
  • M Kathryn Iovine
  • Yan Liu
  • Manvendra K Singh
  • Marc A Wolman
  • Boaz Kigel
  • Carmen Martín-Sierra
  • Donatella Valdembri
  • X Zhao
  • Hugo Gómez-Rueda
  • Mailin Julia Hamm
  • - Gunadi
  • Ellen Knierim
  • Alemji A Taku
  • Javier Gilabert-Juan
  • Abbie L A Binch
  • Marta Sanchez-Castro
  • Mudit Gupta
  • Zheng Hu
  • Michael J McGeachie
  • Vivienne C Ho
  • Qingguang Jiang
  • Kelly Foley
  • Li Li
  • Jonathan A Raper
  • Takayuki Inoue
  • Salud Borrego
  • Marija Orlic-Milacic
  • Raquel M Fernandez
  • Maria X Sosa
  • Connie Choi
  • Stacey Arnold
  • Aravinda Chakravarti
  • Takashi Okitsu
  • Alison L Dell
  • Berta Luzón-Toro
  • Giorgia Jurisic
  • Tamar C Katz
  • Adi D Sabag
  • Quynh V Ton
  • Takashi Fujii
  • Gera Neufeld
  • Amber Y Spencer
  • Hiroshi Takahashi
  • Mami Ishida
  • L Karayan-Tapon
  • Yung Shu Kuan
  • Mariko Sato
  • K A Elsaid
  • K Lassiter
  • Zhe Jin
  • Jason D Berndt
  • Jill A Sakai
  • Michael J F Barresi
  • M A Deberg
  • Michelle Deberg
  • Hiroshi Tawarayama
  • Jahan Ara
  • Wataru Shoji
  • Angel Batuecas-Caletrio
  • Jose A Lopez-Escamez
  • Alvaro Gallego-Martinez
  • Teresa Requena
  • Lidia Frejo
  • Y Dong
  • Wiebke Herzog
  • Anne van Riesen
  • Klaus Zerres
  • Q Xu

Detail Information

Publications62

  1. pmc Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?
    L Karayan-Tapon
    Universite de Poitiers, EA 3805, CHU de Poitiers, 2 rue de la Miletrie, BP 577, Poitiers F 86021, France
    Br J Cancer 99:1153-60. 2008
    ..In these tumours, SEMA3B, SEMA3G and NRP2 expressions were related to prolonged survival. In addition, SEMA3D expression was reduced in high-grade as compared with low-grade gliomas...
  2. pmc Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease
    Carmen Martín-Sierra
    Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO Centre for Genomics and Oncological Research Pfizer University of Granada Junta de Andalucía, PTS, Granada, Spain
    Eur J Hum Genet 25:200-207. 2017
    ..Here, we have identified two novel and rare heterozygous variants in the SEMA3D and DPT genes segregating with the complete phenotype that have variable expressivity in two pedigrees with AD-FMD...
  3. doi In vivo analysis of Arg-Gly-Asp sequence/integrin α5β1-mediated signal involvement in embryonic enchondral ossification by exo utero development system
    Takayuki Inoue
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Shimane, Japan
    J Bone Miner Res 29:1554-63. 2014
    ..The ratios of type X collagen to type 2 collagen mRNA and protein (Coll X/Coll 2) were significantly lower in the RGDS-injected limbs...
  4. pmc Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells
    Boaz Kigel
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 3:e3287. 2008
    ..To determine if additional class-3 semaphorins such as sema3A, sema3D, sema3E and sema3G possess anti-angiogenic and anti-tumorigenic properties, we expressed the recombinant full ..
  5. pmc Hapln1a is required for connexin43-dependent growth and patterning in the regenerating fin skeleton
    Jayalakshmi Govindan
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 9:e88574. 2014
    ..Attempts to place hapln1a in our previously defined cx43-sema3d pathway suggest that hapln1a functions in a parallel genetic pathway...
  6. pmc Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression
    Marija Orlic-Milacic
    Molecular Neuropsychiatry and Development Lab, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    PLoS ONE 9:e91742. 2014
    ..up-regulation of several genes resulting from over-expression of MECP2_e1 including SRPX2, NAV3, NPY1R, SYN3, and SEMA3D. DOCK8 was shown via microarray and qRT-PCR to be upregulated in both SK-N-SH cells and mouse fibroblasts...
  7. pmc Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways
    Haig Aghajanian
    From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Biol Chem 289:17971-9. 2014
    ..We showed recently that semaphorin 3d (Sema3d) mediates endothelial cell repulsion and pulmonary vein patterning during embryogenesis...
  8. doi Disruption of the SEMA3D gene in a patient with congenital heart defects
    Marta Sanchez-Castro
    INSERM, UMR1087, l institut du thorax, Nantes, France Université de NANTES, Nantes, France
    Hum Mutat 36:30-3. 2015
    ..By array comparative genomic hybridization, we identified a duplication of the 5' half of semaphorin3D (SEMA3D). Breakpoint sequencing and fiber fluorescent in situ hybridization showed tandem duplication...
  9. doi Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
    Zheng Hu
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Nat Genet 47:158-63. 2015
    ..8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%). Protein expression from FHIT and LRP1B was downregulated when HPV integrated in their introns...
  10. pmc Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability
    Qian Jiang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China
    Am J Hum Genet 96:581-96. 2015
    ..Analysis in Ret wild-type and Ret-null mice demonstrates specific expression of Sema3a, Sema3c, and Sema3d in the enteric nervous system (ENS)...
  11. pmc CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies
    Michael J McGeachie
    Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, Mass Electronic address
    J Allergy Clin Immunol 136:1503-10. 2015
    ..Asthma exacerbations are a major cause of morbidity and medical cost...
  12. pmc Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer
    Kelly Foley
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Sci Signal 8:ra77. 2015
    ..The expression of the gene encoding semaphorin 3D (Sema3D) is increased in PDA tumors, and the presence of antibodies against the pleiotropic protein annexin A2 ..
  13. doi Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations
    Javier Gilabert-Juan
    CIBERSAM, Spain Departamento de Genética, Facultad de Biologia, Universitat de Valencia, INCLIVA, Valencia, Spain Unidad de Neurobiología y Programa de Neurociencias Básicas y Aplicadas, Departamento de Biologia Celular, Universitat de Valencia, INCLIVA, Valencia, Spain
    Psychiatry Res 229:850-7. 2015
    ..PLXNB1, SEMA3A, SEMA4D and SEM6C were upregulated in SNA or SA patients compared to controls. PLXNA1 and SEMA3D showed down-regulation in their expression in the patient's samples, but differences remained statistically ..
  14. pmc Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target
    Alemji A Taku
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 143:123-32. 2016
    ..In search of additional cues that guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb and acts as a repellent that pushes them towards the CZ...
  15. pmc Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1
    Mailin Julia Hamm
    Cells in Motion Cluster of Excellence, University of Muenster, 48149 Muenster, Germany
    J Cell Biol 215:415-430. 2016
    ..Recently, SEMA3D gene disruptions were associated with cardiovascular defects in patients; however, the mechanisms of action were ..
  16. ncbi Effects of SEMA3 polymorphisms in Hirschsprung disease patients
    - Gunadi
    Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada Dr Sardjito Hospital, Jl Kesehatan No 1, Yogyakarta, 55281, Indonesia
    Pediatr Surg Int 32:1025-1028. 2016
    Recently, genetic markers within a locus on 7q21.11 containing the SEMA3A, SEMA3C, and SEMA3D genes were reported to be associated with Hirschsprung disease (HSCR)...
  17. pmc Class 3 semaphorins in cardiovascular development
    Donatella Valdembri
    a Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy
    Cell Adh Migr 10:641-651. 2016
    ..Subsequently, Sema3A, Sema3C, Sema3D, and Sema3E were discovered to play crucial roles in cardiovascular development, mainly acting through Nrp1 and ..
  18. pmc Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
    Haig Aghajanian
    Department of Cell and Developmental Biology, Penn Cardiovascular Institute, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 7:12038. 2016
    ..where it partners with neuropilin 1 (Nrp1) to form a functional receptor for the vascular guidance molecule semaphorin 3d (Sema3d)...
  19. pmc Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells
    X Zhao
    Department of Orthopaedics, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Cell Death Dis 7:e2188. 2016
    ..Taken together, our results reveal new links between obesity and cartilage damage that are induced by leptin-mediated effects on cell behaviour and senescence. ..
  20. doi A robust biomarker of differential correlations improves the diagnosis of cytologically indeterminate thyroid cancers
    Hugo Gómez-Rueda
    Bioinformatics Research Group, Department of Research and Innovation, Medical School, Tecnológico de Monterrey, Colonia Los Doctores, 64710 Monterrey, Nuevo Leon, Mexico
    Int J Mol Med 37:1355-62. 2016
    ..expression of the following genes: CCND1, CLDN16, CPE, LRP1B, MAGI3, MAPK6, MATN2, MPPED2, PFKFB2, PTPRE, PYGL, SEMA3D, SERGEF, SLC4A4 and TIMP1...
  21. pmc Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures
    Ellen Knierim
    Department of Neuropediatrics, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany NeuroCure Clinical Research Center, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Am J Hum Genet 98:473-89. 2016
    ..fibroblasts downregulated genes associated with neurogenesis, neuronal migration, and pathfinding (SERPINF1, DAB1, SEMA3D, SEMA3A), as well as with bone development (TNFRSF11B, RASSF2, STC1)...
  22. pmc Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration
    Jayalakshmi Govindan
    Department of Biological Sciences, 111 Research Drive, Iacocca B217, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 11:e0148202. 2016
    ..Moreover, we provide evidence that the Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration...
  23. doi [Difficulties and limitations in conducting translational research in thoracic oncology. A practical example]
    A P Meert
    Service des Soins Intensifs, urgences oncologiques et oncologie thoracique, Institut Jules Bordet, Universite Libre de Bruxelles, 1, Rue Heger Bordet, 1000 Bruxelles, Belgique Electronic address
    Rev Mal Respir 33:594-9. 2016
    In a first study, we identified signatures of 3 mRNAs (semaphorin 3D [SEMA3D], cytokeratin 16 [KRT16] and UL16 binding protein 2 [ULBP2]) associated to response to a cisplatin-vinorelbin chemotherapy and to survival of advanced non-..
  24. pmc Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc
    Abbie L A Binch
    Sheffield Hallam University, Sheffield, South Yorkshire, United Kingdom
    Oncotarget 6:18338-54. 2015
    ..This is the first study to identify sema3C, sema3D and their receptors within the nucleus pulposus of intervertebral discs...
  25. pmc Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells
    Tamar C Katz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 22:639-50. 2012
    ..Here we resolve this conflict by identifying two proepicardial markers, Scleraxis (Scx) and Semaphorin3D (Sema3D), that genetically delineate heretofore uncharacterized proepicardial subcompartments...
  26. pmc cAMP-induced expression of neuropilin1 promotes retinal axon crossing in the zebrafish optic chiasm
    Alison L Dell
    Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:11076-88. 2013
    ..These errors resemble misprojections in adcy1, adcy8, nrp1a, sema3D, or sema3E morphant embryos, as well as in sema3D mutant embryos...
  27. pmc Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections
    Karl Degenhardt
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 19:760-5. 2013
    ..Here we show that the secreted guidance molecule semaphorin 3d (Sema3d) is crucial for the normal patterning of pulmonary veins...
  28. doi Substituent Effect of Bis(pyridines)iodonium Complexes as Iodinating Reagents: Control of the Iodocyclization/Oxidation Process
    Takashi Okitsu
    Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558 Japan, Fax 81 78 441 7562
    Chemistry 19:4992-6. 2013
    ..This reagent-controlled system enabled switchable access to 2,3-dihydropyrroles and pyrroles...
  29. pmc Mutational spectrum of semaphorin 3A and semaphorin 3D genes in Spanish Hirschsprung patients
    Berta Luzón-Toro
    Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville, University Hospital Virgen del Rocío Consejo Superior de Investigaciones Científicas University of Seville, Seville, Spain
    PLoS ONE 8:e54800. 2013
    ..1) and SEMA3D (7q21.11) through SNP array analyses and by next-generation sequencing technologies...
  30. doi Serological markers of erosive hand osteoarthritis
    Roberta Ramonda
    Rheumatology Unit, Department of Medicine DIMED, University of Padova, Italy
    Eur J Intern Med 24:11-5. 2013
    ..The most useful cartilage markers in both erosive and non-erosive HOA, seems to be collagen (Coll) 2-1, Coll 2-1NO(2) and Col2-3/4C(short)...
  31. pmc Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain
    Adi D Sabag
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 7:e42912. 2012
    ..b>Sema3D and sema3E displayed the strongest inhibitory effects and their expression in U373MG or in U87MG glioblastoma ..
  32. pmc An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation
    Giorgia Jurisic
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland
    Circ Res 111:426-36. 2012
    ..Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and in the pathology of human diseases. Yet, the molecular mechanisms that control lymphatic vessel maturation remain largely unknown...
  33. pmc Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration
    Quynh V Ton
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, USA
    Dev Biol 366:195-203. 2012
    ..Here we demonstrate that semaphorin3d (sema3d) functions downstream of Cx43...
  34. pmc A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro
    Alun Hughes
    Musculoskeletal Research Programme, School of Medicine and Dentistry, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Calcif Tissue Int 90:151-62. 2012
    ..are expressed in mouse osteoblasts and are differentially regulated by cell growth and differentiation: Sema3d expression is increased and Sema3e expression decreased during proliferation in culture, while expression of ..
  35. ncbi Modulation of sciatic nerve expression of class 3 semaphorins by nerve injury
    Jahan Ara
    Division of Neurology, Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1153-9. 2004
    ..a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins (Sema3A, Sema3B, Sema3C, Sema3E, and Sema3F, but not Sema3D) in crushed or transected sciatic nerves.
  36. ncbi New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis
    Michelle Deberg
    Bone and Cartilage Research Unit, University of Liege, Sart Tilman, 4000 Liege, Belgium
    Osteoarthritis Cartilage 13:258-65. 2005
    ..We have developed immunoassays specific for a peptide of the alpha-helical region of type II collagen 108HRGYPGLDG116 (Coll 2-1) and its nitrated form 108HRGY(NO2)PGLDG116 (Coll 2-1 NO2) in biological fluids.
  37. ncbi One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression
    M A Deberg
    University of Liege, Institute of Pathology, Level 5, Bone and Cartilage Research Unit, CHU Sart Tilman, 4000 Liege, Belgium
    Osteoarthritis Cartilage 13:1059-65. 2005
    ..To analyse the relationship between the levels of urinary biochemical markers of type II collagen degradation and the clinical and radiological severity and progression of knee osteoarthritis (OA)...
  38. ncbi Review: Collagen markers in early arthritic diseases
    K A Elsaid
    Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA
    Clin Chim Acta 365:68-77. 2006
    ..CII degradation markers include CII C-telopeptide (CII-X), CII neoepitope (TIINE), helix II, C2C, CNBr 9.7, Coll 2-1, and Coll 2-1 NO(2). Most of these markers differentiate between early stages of OA, RA and reference controls...
  39. ncbi Differential expression of mitochondrial and extramitochondrial proteins in lymphocytes of male broilers with low and high feed efficiency
    K Lassiter
    Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:2251-9. 2006
    ..protein spot of ~33 kDa was tentatively identified by MALDI-TOF as a fragment of collapsin-2, a component of semaphorin 3D. The results of this study provide further evidence of increased oxidation associated with low FE and further ..
  40. ncbi Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum
    Yan Liu
    Department of Zoology and Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 24:310-8. 2004
    We examined the role of Sema3D, a semaphorin of previously unknown function, in guiding retinal ganglion cell (RGC) axons to the optic tectum in the developing zebrafish...
  41. ncbi A family of molecules related to collapsin in the embryonic chick nervous system
    Y Luo
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 14:1131-40. 1995
    ..This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations...
  42. ncbi Type II collagen peptides for measuring cartilage degradation
    Y Henrotin
    Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart Tilman, 4000 Liege, Belgium
    Biorheology 41:543-7. 2004
    This paper describes two new immunoassays for a peptide of the triple helix of type II collagen (Coll 2-1) and its nitrated form (Coll 2-1 NO(2))...
  43. ncbi Semaphorin profiling of periodontal fibroblasts and osteoblasts
    T E Lallier
    Louisiana State University Health Science Center, Department of Cell Biology and Anatomy, Center of Excellence in Oral and Craniofacial Biology, School of Dentistry, 1100 Florida Avenue, New Orleans 70119, USA
    J Dent Res 83:677-82. 2004
    ..Analysis of the data suggests that differential expression of semaphorins and plexins may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure...
  44. ncbi Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo
    Marc A Wolman
    Department of Zoology and Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 24:8428-35. 2004
    ..We investigated the role of Semaphorin3D (Sema3D) in the formation of the early axon pathways in the zebrafish CNS...
  45. ncbi Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain
    Michael J F Barresi
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 132:3643-56. 2005
    ..glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 and sema3d, but that Hh does not appear to play a direct role in commissural and retinal axon guidance...
  46. pmc Sema3D, Sema3F, and Sema5A are expressed in overlapping and distinct patterns in chick embryonic heart
    Zhe Jin
    Department of Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 235:163-9. 2006
    ..We analyzed the expression patterns of Sema3D, Sema3F, and Sema5A genes in the chick embryonic heart by in situ hybridization...
  47. ncbi Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1
    Yan Liu
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 25:10556-63. 2005
    ..We show that a semaphorin expressed at the dorsal spinal cord midline, Semaphorin3D (Sema3D), may act to repel the peripheral axons out of the spinal cord...
  48. ncbi Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish
    Jill A Sakai
    Neuroscience Training Program, Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Development 133:1035-44. 2006
    ..Here we show that Sema3d, a secreted semaphorin expressed at the midline, guides the crossing of RGC axons in zebrafish...
  49. pmc Sema3D and Sema7A have distinct expression patterns in chick embryonic development
    Zheng Zheng Bao
    Department of Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 02115, USA
    Dev Dyn 235:2282-9. 2006
    ..We further analyzed its expression patterns and compared them with those of the Sema3D gene, in chick embryonic development. Sema3D and Sema7A appeared to be expressed in distinct cell populations...
  50. ncbi Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field
    Mariko Sato
    Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 298:12-21. 2006
    ..b>Sema3D morphants have subsequent complex congenital heart defects, including hypertrophic cardiomyocytes, decreased ..
  51. ncbi Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain
    Jason D Berndt
    Department of Zoology and Anatomy and Neuroscience Training Program, University of Wisconsin, Madison, WI 53706, USA
    Development 133:3983-92. 2006
    ..Morpholino-mediated knockdown of Sema3d inhibits the proliferation of hindbrain neuroepithelial cells...
  52. ncbi Neuropilin asymmetry mediates a left-right difference in habenular connectivity
    Yung Shu Kuan
    Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 134:857-65. 2007
    ..Selective depletion of Sema3D, but not of other Sema family members, similarly disrupts innervation of the dorsal IPN...
  53. ncbi Plasma concentrations of a type II collagen-derived peptide and its nitrated form in growing Ardenner sound horses and in horses suffering from juvenile digital degenerative osteoarthropathy
    J Ph Lejeune
    Centre Européen du Cheval, Mont le Soie, Vielsalm, Belgium
    Vet Res Commun 31:591-601. 2007
    ..b>Coll 2-1, a peptide of the helical region of type II collagen, and its nitrated form (Coll 2-1 NO(2)) were assayed in ..
  54. ncbi Influence of extracellular matrix coatings on implant stability and osseointegration: an animal study
    Bernd Stadlinger
    Faculty of Medicine, Department of Maxillofacial Surgery, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    J Biomed Mater Res B Appl Biomater 83:222-31. 2007
    ..051. It was concluded that collagen and coll/CS implant coatings have advantageous characteristics for peri-implant bone formation, compared with the further integration of BMP-4...
  55. ncbi Semaphorin3D regulates axon axon interactions by modulating levels of L1 cell adhesion molecule
    Marc A Wolman
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 27:9653-63. 2007
    ..Here we describe crosstalk between molecules that mediate these mechanisms. We show that Semaphorin3D (Sema3D), a classic repulsive molecule, promotes fasciculation by regulating L1 CAM levels and axon-axon interactions ..
  56. doi Identification and tissue-specific expression of a novel isoform of Semaphorin 3D
    Kaoru Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Biochim Biophys Acta 1790:395-400. 2009
    ..There has been no report on the expression of different transcripts of the genes encoding Class 3 Semaphorins with different protein structures...
  57. doi Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
    Gustav Lehne
    Department of Clinical Pharmacology, Oslo University Hospital Rikshospitalet, Norway
    Leuk Res 33:1379-85. 2009
    ..In K562VCR array CGH revealed amplification of ABCB1, ABCB4, ABCB5 and SEMA3D, whereas expression microarrays demonstrated upregulation of stem cell genes (e.g...
  58. doi Expression of Sema3D in subsets of neurons in the developing dorsal root ganglia of the rat
    Kaoru Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Neurosci Lett 455:17-21. 2009
    We investigated the expression of the semaphorin family member, Sema3D, in the developing dorsal root ganglia of the rat. Sema3D expression was observed in a subpopulation of dorsal root ganglion (DRG) neurons...
  59. doi Mechanical tension alters semaphorin expression in the periodontium
    Amber Y Spencer
    Department of Cell Biology and Anatomy, Center of Excellence in Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Science Center, New Orleans, LA 70119, USA
    J Periodontol 80:1665-73. 2009
    ..We predicted that mechanical tension alters the expression of the subset of semaphorins in the periodontium likely to be most involved with regulating the remodeling of this tissue...
  60. doi Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    J Psychiatr Res 45:47-53. 2011
    ..This finding prompted us to examine the possible association between the semaphorin 3D gene (SEMA3D) and schizophrenia in a Japanese population...
  61. doi Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons
    Hideomi Tanaka
    Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute BSI, Saitama, Japan
    Dev Dyn 240:9-22. 2011
    ..AMO)-mediated knockdown of dpysl3 inhibited the outgrowth of the peripheral axons of RB neurons, and semaphorin 3d (sema3d) AMO enhanced this effect...
  62. pmc Rapid and efficient human mutation detection using a bench-top next-generation DNA sequencer
    Qian Jiang
    Center for Complex Disease Genomics, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Hum Mutat 33:281-9. 2012
    ..solution for mutation detection by amplicon sequencing of three type 3 semaphorin genes SEMA3A, SEMA3C, and SEMA3D implicated in Hirschsprung disease (HSCR)...

Research Grants8

  1. Determining the role of sema3d during fin regeneration
    MARY KATHRYN IOVINE; Fiscal Year: 2013
    ..Interestingly, the gene for a secreted semaphorin, sema3d, is expressed in the regenerating fin in a cx43-dependent manner...
  2. Karl Degenhardt; Fiscal Year: 2014
    ..Targeted mutation of Sema3D has results in TAPVR/PAPVR in mice...
  3. Jonathan A Epstein; Fiscal Year: 2016
    ..We have generated two distinct null alleles of a poorly studied class III semaphorin, sema3d, which results in anomalous pulmonary venous return...
  4. Lei Zheng; Fiscal Year: 2016
    ..studies have led to the second part of our hypothesis that ANXA2 regulates PDA invasion and metastasis through Sema3d/Plxnd1, both belonging to an axon guidance pathway. We therefore propose two aims to test these hypotheses...
  5. Role of Semaphorins in axonal guidance
    JOHN KUWADA; Fiscal Year: 2005
    ..This application will examine whether Sema3D, whose function is unknown in any organism, attracts and/or induces branching by axons in vivo in zebrafish ..
  6. Molecular mechanisms guiding axon fasciculation
    MARC WOLMAN; Fiscal Year: 2006
    ..MLF axons defasciculate following knockdown of Sema3D signaling and fail to initially converge and subsequently extend after TAG-1 knockdown...
  7. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
    ..The proposed research will address how midline cell types (glial cells) and the midline molecular guidance cue Sema3D influence pathfinding decisions of retinal ganglion cell (RGC) and post optic commissure (POC) axons in the ..
  8. Expression and regulation of the axon guidance cues
    Zheng Zheng Bao; Fiscal Year: 2009
    ....