SELPLG

Summary

Gene Symbol: SELPLG
Description: selectin P ligand
Alias: CD162, CLA, PSGL-1, PSGL1, cutaneous lymphocyte-associated associated antigen
Species: human

Top Publications

  1. doi Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    Nat Med 15:794-7. 2009
  2. pmc Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 9:e1003511. 2013
  3. pmc Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 6:e1001174. 2010
  4. pmc HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region
    G Nicholas Llewellyn
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Virol 87:6441-54. 2013
  5. pmc Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1
    Kohei Miyamura
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 92:287-91. 2011
  6. doi Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians
    Lakhdar Ghazouani
    Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Monastir, 5000, Tunisia
    Mol Biol Rep 38:495-501. 2011
  7. ncbi The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
    Stefan F Lichtenthaler
    Massachusetts General Hospital Harvard Medical School, Department of Molecular Biology, Boston, Massachusetts 02114, USA
    J Biol Chem 278:48713-9. 2003
  8. ncbi CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
    Luca Battistini
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
    Blood 101:4775-82. 2003
  9. pmc Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection
    Hsiang Yin Lin
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    J Virol 87:9064-76. 2013
  10. pmc Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x
    Arkadiusz G Klopocki
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 283:11493-500. 2008

Detail Information

Publications217 found, 100 shown here

  1. doi Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    Nat Med 15:794-7. 2009
    ..Here we identify human P-selectin glycoprotein ligand-1 (PSGL-1; CD162), a sialomucin membrane protein expressed on leukocytes that has a major role in early stages of inflammation, as ..
  2. pmc Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 9:e1003511. 2013
    ....
  3. pmc Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 6:e1001174. 2010
    ..Thus, the results presented in this study reveal that tyrosine sulfation, but not O-glycosylation, in the N-terminal region of PSGL-1 may facilitate virus entry and replication of EV71 in leukocytes...
  4. pmc HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region
    G Nicholas Llewellyn
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Virol 87:6441-54. 2013
    ..Taken together, these findings revealed that HIV-1 Gag associates with specific microdomains present in polarized T cells in an MA-dependent manner, which results in modification of the microdomain constituents...
  5. pmc Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1
    Kohei Miyamura
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 92:287-91. 2011
    ..The results suggest that an adaptive mutation, along with a PSGL-1-binding phenotype, may facilitate efficient PSGL-1-dependent replication of the EV71 strains in L-PSGL-1 cells...
  6. doi Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians
    Lakhdar Ghazouani
    Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Monastir, 5000, Tunisia
    Mol Biol Rep 38:495-501. 2011
    ..However, this study replicates absence of association of the mostly studied SNP, T715P, previously reported in individuals with African origin...
  7. ncbi The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
    Stefan F Lichtenthaler
    Massachusetts General Hospital Harvard Medical School, Department of Molecular Biology, Boston, Massachusetts 02114, USA
    J Biol Chem 278:48713-9. 2003
    ..The cleavage occurred at a Leu-Ser peptide bond as identified by mass spectrometry using a synthetic peptide. We conclude that PSGL-1 is an additional substrate for BACE1...
  8. ncbi CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
    Luca Battistini
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
    Blood 101:4775-82. 2003
    ..In conclusion, our results show that CD8+, but not CD4+, T cells from patients with RRMS in the acute phase of the disease display increased ability to be recruited in inflamed brain venules...
  9. pmc Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection
    Hsiang Yin Lin
    Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    J Virol 87:9064-76. 2013
    ..A receptor-dominated endocytosis of EV71 infection was observed: PSGL-1 initiates caveola-dependent endocytosis and hSCARB2 activates clathrin-dependent endocytosis. ..
  10. pmc Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x
    Arkadiusz G Klopocki
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 283:11493-500. 2008
    ..These results distinguish molecular mechanisms for L-selectin to bind to PSGL-1 and peripheral node addressin and explain in part the shorter lifetimes of PSGL-1 bonds with L-selectin than P-selectin...
  11. pmc Ezrin-radixin-moesin-binding sequence of PSGL-1 glycoprotein regulates leukocyte rolling on selectins and activation of extracellular signal-regulated kinases
    Caroline Spertini
    Service and Central Laboratory of Hematology, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    J Biol Chem 287:10693-702. 2012
    ....
  12. ncbi Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils
    Chad E Green
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Immunol 172:7780-90. 2004
    ..Taken together, the data suggest that E-selectin is unique among selectins in its capacity for clustering sialylated ligands and transducing signals leading to neutrophil arrest in shear flow...
  13. ncbi 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells
    Knut Schakel
    Institute of Immunology, Technical University of Dresden, Dresden, Germany
    Immunity 17:289-301. 2002
    ..In contrast to previously described blood DCs, M-DC8+ DCs lack the cutaneous lymphocyte antigen (CLA) on PSGL-1 and fail to bind P and E selectin...
  14. ncbi Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease
    Peter Bugert
    Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden Württemberg Hessia, Ruprecht Karls University Heidelberg, Faculty of Clinical Medicine Mannheim, Mannheim, Germany
    Clin Chem Lab Med 42:997-1004. 2004
    ..However, the functional role of the gene variants should be elucidated by further experimental data...
  15. ncbi A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin
    K R Snapp
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 91:154-64. 1998
    ..Variation in tyrosine sulfation during B-cell differentiation may affect the ability of B cells to interact with P- and L-selectin...
  16. ncbi ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1
    Ana Urzainqui
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Immunity 17:401-12. 2002
    ..These data unveil a new functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases and show that PSGL-1 is a signaling molecule in leukocytes...
  17. ncbi Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
    ....
  18. ncbi Expression cloning of a functional glycoprotein ligand for P-selectin
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 75:1179-86. 1993
    ..A soluble ligand construct, when coexpressed with fucosyltransferase in COS cells, also mediates P-selectin binding and is immunocrossreactive with the major HL-60 glycoprotein that specifically binds P-selectin...
  19. pmc P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue
    Hana M Russo
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 0644, USA
    Circ Res 107:388-97. 2010
    ..Adhesive interactions between endothelial cells and leukocytes affect leukocyte trafficking in adipose tissue. The role of P-selectin glycoprotein ligand-1 (Psgl-1) in this process is unclear...
  20. doi Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line
    Bouchaib Bahbouhi
    INSERM, UMR 643, Institut de Transplantation et de Recherches en Transplantation, ITERT, Nantes 44900, France
    J Leukoc Biol 86:1049-63. 2009
    ..Collectively, MS is associated with an expanding pool of PSGL-1+CD4+ T lymphocytes able to transmigrate the BBB endothelium in vitro and possibly contributing to brain pathology...
  21. ncbi PG-M/versican binds to P-selectin glycoprotein ligand-1 and mediates leukocyte aggregation
    Peng Sheng Zheng
    Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    J Cell Sci 117:5887-95. 2004
    ..Taken together, our results strongly support a physiologically relevant role for PSGL-1/versican binding and may have implications in the immunoresponse...
  22. pmc Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
    Yoshihiro Kuwano
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA, USA
    Blood 116:617-24. 2010
    ..Similar to mouse neutrophils, this was dependent on P-selectin glycoprotein ligand 1 (PSGL1), alpha(L)beta(2) integrin, the Src family tyrosine kinase FGR and spleen tyrosine kinase SYK...
  23. pmc Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells
    G Nicholas Llewellyn
    Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 6:e1001167. 2010
    ..Taken together, these results support a model in which NC-dependent Gag accumulation to uropods establishes a preformed platform that later constitutes T-cell-T-cell contacts at which HIV-1 virus transfer occurs...
  24. pmc PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
    Philippe Foubert
    Institut des Vaisseaux et du Sang, Paris, France
    J Clin Invest 117:1527-37. 2007
    ..Therefore, activation of EphB4 is an innovative and potentially valuable therapeutic strategy for improving the recruitment of EPCs to sites of neovascularization and thereby the efficiency of cell-based proangiogenic therapy...
  25. pmc Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles
    Elzbieta Pluskota
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
    Blood 112:2327-35. 2008
    ..Thus, cooperation of these 2 receptor/counterreceptor systems regulates the prothrombotic properties of PMN-derived MPs...
  26. pmc Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters
    Eric Y H Park
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Biophys J 82:1835-47. 2002
    ..Our results suggest that microvillus extension during transient PSGL-1/P-selectin bonding may enhance the robustness of neutrophil rolling interactions...
  27. ncbi Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1
    M J Herron
    Division of Infectious Diseases, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Science 288:1653-6. 2000
    ..Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1. Selectin mimicry is likely central to the organism's unique ability to target and infect neutrophils...
  28. ncbi Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
    R C Fuhlbrigge
    Harvard Skin Disease Research Center, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 389:978-81. 1997
    ..that infiltrate the skin express a unique skin-homing receptor called cutaneous lymphocyte-associated antigen (CLA), a carbohydrate epitope that facilitates the targeting of T cells to inflamed skin...
  29. pmc Dynamic Association between HIV-1 Gag and Membrane Domains
    Ian B Hogue
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Biol Int 2012:979765. 2012
    ..Relationships between Gag multimerization and microdomain association will be further discussed in the context of Gag localization to T-cell uropods and virological synapses...
  30. ncbi A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140, USA
    Cell 83:323-31. 1995
    ..We propose that this sulfotyrosine-containing segment of PSGL-1, in conjunction with sLex presented on O-linked glycans, constitutes the high affinity P-selectin-binding site...
  31. ncbi Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin
    T K Epperson
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 275:7839-53. 2000
    ..These results demonstrate that Cys(320)-dependent dimerization of PSGL-1 is not required for binding to P-selectin and that a small monomeric fragment of PSGL-1 is sufficient for P-selectin recognition...
  32. pmc P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo
    P S Frenette
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 191:1413-22. 2000
    ..Our results indicate that functional PSGL-1 is expressed on platelets, and suggest an additional mechanism by which selectins and their ligands participate in inflammatory and/or hemostatic responses...
  33. ncbi Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow
    G Woltmann
    Division of Respiratory Medicine, University of Leicester School of Medicine, Glenfield Hospital, Leicester, UK
    Blood 95:3146-52. 2000
    ..This mechanism is likely to be a key event leading to the selective accumulation of eosinophils in allergic inflammation...
  34. pmc Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
    Alexander Zarbock
    Department of Anesthesiology and Intensive Care Medicine, University of Münster and Max Planck Institute, Germany
    Blood 118:6743-51. 2011
    ..Although the physiologic characterization of these ligands has been obtained in mice, we also note reported similarities and differences with human selectin ligands...
  35. ncbi The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives
    R S Peterson
    Department of Biochemistry and Molecular Biology, University of Illinois at Chicago, College of Medicine, 60612 7334, USA
    Mech Dev 69:53-69. 1997
    ....
  36. ncbi Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin
    P P Wilkins
    Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Biol Chem 270:22677-80. 1995
    ..These studies demonstrate that tyrosine sulfate on PSGL-1 functions in conjunction with sialylated and fucosylated glycans to mediate high affinity binding to P-selectin...
  37. ncbi Immunoblockade of PSGL-1 attenuates established experimental murine colitis by reduction of leukocyte rolling
    Emile M Rijcken
    Dept of General Surgery, Muenster University Hospital, Waldeyerstrasse 1, D 48149 Muenster, Germany
    Am J Physiol Gastrointest Liver Physiol 287:G115-24. 2004
    ..Therapeutic strategies designed to disrupt interactions mediated by PSGL-1 and/or VLA-4 may prove beneficial in treatment of chronic colitis...
  38. ncbi Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin
    F Li
    W K Warren Medical Research Institute, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73140, USA
    J Biol Chem 271:3255-64. 1996
    ..These results demonstrate that PSGL-1 requires core 2 O-linked glycans that are sialylated and fucosylated to bind P- and E-selectin. PSGL-1 also requires tyrosine sulfate to bind P-selectin but not E-selectin...
  39. ncbi Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin
    Anne Leppanen
    Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Biol Chem 278:26391-400. 2003
    ..These results demonstrate that L-selectin binds with high affinity to the N-terminal region of PSGL-1 through cooperative interactions with three sulfated tyrosine residues and an appropriately positioned C2-O-sLex O-glycan...
  40. ncbi Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains
    Saotomo Itoh
    Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    J Leukoc Biol 81:1414-21. 2007
    ....
  41. ncbi P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium
    Paula da Costa Martins
    Department of Experimental Immunohematology, Sanquin Research, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1023-9. 2007
    ..The purpose of this study was to investigate the presence and functionality of P-selectin glycoprotein ligand-1 (PSGL-1) on activated endothelial cells (ECs)...
  42. pmc Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime
    K E Edmondson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Biophys J 89:3603-14. 2005
    ..Membrane tether growth can be enhanced or reduced pharmacologically with consequent effects on PSGL-1/P-selectin lifetimes...
  43. ncbi The variable number of tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene is not associated with coronary heart disease
    Peter Bugert
    Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden Württemberg Hessia, Ruprecht Karl University Heidelberg, Faculty of Clinical Medicine Mannheim, Friedrich Ebert Strasse 107, 68167 Mannheim, Germany
    J Mol Med (Berl) 81:495-501. 2003
    ..Adequately powered studies are prerequisites to obtain reliable results about genotype-phenotype relationships of new candidate genes in complex diseases...
  44. ncbi Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin
    McRae J Smith
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biol Chem 279:21984-91. 2004
    ..Both C2GlcNAcT-I glycosylation and PSGL-1 dimerization increased the rate of tethering to P-selectin under flow, whereas C2GlcNAcT-I levels primarily influenced tether bond strength...
  45. pmc Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study
    Kelly A Volcik
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, United States
    Atherosclerosis 195:e76-82. 2007
    ..We also tested common haplotypes in the PSEL and PSGL-1 genes to assess associations with incident CHD and ischemic stroke...
  46. ncbi Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus
    Takako Hirata
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:51775-82. 2004
    ..2 cells resulted in reduced chemotaxis to CCL27. These findings suggest a role for PSGL-1 in regulating chemokine-mediated responses, in addition to its role as a selectin ligand...
  47. ncbi P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils
    Yan Qing Ma
    University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 104:2549-56. 2004
    P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and integrin alphaMbeta2 (Mac-1, CD11bCD18) are leukocyte adhesion molecules essential for innate immunity and inflammation...
  48. ncbi Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I
    Sylvain Julien
    Breast Cancer Biology Group, King s College London, Guy s Hospital, London, United Kingdom
    J Immunol 179:5701-10. 2007
    ..Our data show that the regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in DC migration...
  49. ncbi A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes
    Juan M Serrador
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Eur J Immunol 32:1560-6. 2002
    ..These results underline the role of moesin in the subcellular redistribution of PSGL-1 in lymphoid cells and make evident the importance of specific serine residues within the cytoplasmic tail of PSGL-1 for this process...
  50. ncbi The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins
    Maria Domínguez-Luis
    Servicio de Reumatologia, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
    Eur J Immunol 41:3436-42. 2011
    ..We conclude that ADAM8 modulates the expression and function of PSGL-1...
  51. ncbi Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions
    Joshua A Boyce
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 99:2890-6. 2002
    ..These observations may explain the abundance of MCs at sites of mucosal inflammation, where VCAM-1 and E-selectin are important inducible receptors...
  52. ncbi Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin
    Karen R Snapp
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 99:4494-502. 2002
    ..Thus, attachment of PSGL-1 to the leukocyte cortical cytoskeleton is essential for leukocyte rolling on P-selectin...
  53. doi Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1
    Kenji Ohba
    AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjyuku ku, Tokyo, Japan
    J Immunol 183:524-32. 2009
    ..We have thus elucidated a novel regulatory mechanism in which FDCs are a potent positive bystander that facilitates HIV-1 replication in adjacent infected monocytic cells via a juxtacrine signaling mechanism...
  54. pmc Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod
    Jérémie Rossy
    Department of Pathology, University of Bern, Bern, Switzerland
    PLoS ONE 4:e5403. 2009
    ..It was the goal of this study to investigate dynamic membrane microdomain reorganization during neutrophil activation...
  55. pmc Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin
    P Andre
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Case 906, 13288 Marseille Cedex 09, France
    Proc Natl Acad Sci U S A 97:3400-5. 2000
    ..These results indicate that NK cell differentiation is accompanied by the acquisition of a unique carbohydrate, PEN5, that can serve as part of a combination code to deliver KIR(+) NK cells to specific tissues...
  56. ncbi P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation
    D A Guyer
    Cytometry, Cancer Research and Treatment Center, University of New Mexico School of Medicine, Albuquerque, USA
    Blood 88:2415-21. 1996
    ..We suggest that L-selectin and PSGL-1 support a collisional cell-cell interaction that represents the first step in neutrophil aggregation...
  57. pmc P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice
    Guangyu An
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Circulation 117:3227-37. 2008
    ..We hypothesize that P-selectin glycoprotein ligand-1 (PSGL-1), the common ligand of P- and E-selectin on leukocytes, contributes to the preferential homing of Ly-6C(hi) monocytes to atherosclerotic lesions...
  58. ncbi Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G
    E E Gardiner
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 98:1440-7. 2001
    ..Cathepsin G- or neutrophil elastase-mediated PSGL-1 proteolysis may constitute a potential autocrine mechanism for down-regulation of neutrophil adhesion to P-selectin...
  59. doi Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status
    Stylianos Bournazos
    The University of Edinburgh MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Arterioscler Thromb Vasc Biol 28:1491-8. 2008
    ....
  60. doi Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery
    Dexter V Reneer
    Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA
    Cell Microbiol 10:1827-38. 2008
    ..PSGL-1 N-terminus recognition promotes optimal AnkA delivery while binding to sLe(x) or the unknown receptor is comparably less important for this process...
  61. pmc Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin
    D J Goetz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 137:509-19. 1997
    ..In addition, the results suggest that PSGL-1 has more than one binding site for E-selectin: one site located within the first 19 amino acids of PSGL-1 and one or more sites located between amino acids 19 through 148...
  62. ncbi Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease
    M L Lozano
    The Unit of Haematology and Clinical Oncology, University General Hospital and School of Medicine, 30003 Murcia, Spain
    Br J Haematol 115:969-76. 2001
    ..008) but not to be related to CHD or DVT. In conclusion, polymorphisms of the PSGL-1 receptor may influence the neutrophil-platelet binding, and represent a risk factor for CVD...
  63. ncbi PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus
    T Pouyani
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Cell 83:333-43. 1995
    ..Rolling of HL-60 cells on P-selectin-coated coverslips is strongly attenuated by treatment of cells with an inhibitor of sulfation...
  64. ncbi The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine
    K L Moore
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
    J Biol Chem 269:23318-27. 1994
    ..These data suggest that PSGL-1 from human neutrophils displays complex, sialylated, and fucosylated O-linked poly-N-acetyllactosamine that promote high affinity binding to P-selectin, but not to E-selectin...
  65. pmc Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and function
    Bénédicte Baïsse
    Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, Bugnon 46, 1011 Lausanne, Switzerland
    BMC Evol Biol 7:166. 2007
    ....
  66. ncbi Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study
    O Simonetti
    Clinica Dermatologica, Universita Politecnica delle Marche, Ospedale Regionale, Via Conca 20, 60020 Torrette, Ancona, Italy
    Br J Dermatol 150:940-8. 2004
    ..The cutaneous lymphocyte-associated antigen (CLA) and the skin-associated chemokine CCL27 highlight an important role for epithelial cells in controlling ..
  67. ncbi The role of the carrier protein and disulfide formation in the folding of beta-lactamase fusion proteins in the endoplasmic reticulum of yeast
    M Simonen
    Institute of Biotechnology, University of Helsinki, Finland
    J Biol Chem 269:13887-92. 1994
    ..Fusion of beta-lactamase to the C terminus of hsp150 produced Cla-bla protein, which was secretion-competent but inactive...
  68. ncbi Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor
    J Yang
    Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
    Blood 87:4176-86. 1996
    ..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin...
  69. pmc P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration
    T Hirata
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Exp Med 192:1669-76. 2000
    ..These data provide evidence that PSGL-1 on Th1 cells functions as one of the E-selectin ligands in vivo...
  70. ncbi Expression of HDL receptor, CLA-1 in human smooth-muscle cells and effect of interferon-gamma on its regulation
    H Imachi
    First Department of Internal Medicine, Kagawa Medical University, Japan
    Horm Metab Res 33:389-93. 2001
    ..We previously identified human scavenger receptor BI (hSR-BI/CLA-1) as a receptor for human HDL, but did not examine the expression of hSR-BI/CLA-1 in smooth-muscle cells...
  71. ncbi Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity
    D Armerding
    Division of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Mass, USA
    Int Arch Allergy Immunol 126:78-90. 2001
    Skin-homing T cells are defined by the expression of the cutaneous lymphocyte-associated antigen (CLA) which enables the cells to selectively bind to vascular endothelial E-selectin close to sites of cutaneous inflammation, an initial ..
  72. ncbi Total lipids of Sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomers
    Viviana Santercole
    Faculty of Veterinary Medicine, University of Sassari, 07100, Sassari, Italy
    Lipids 42:361-82. 2007
    ..meat included the fatty acids from O-acyl and N-acyl lipids, including the trans- and conjugated linoleic acid (CLA) isomers and the alk-1-enyl ethers from the plasmalogenic lipids...
  73. ncbi Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins, and its proportion in fasting serum and erythrocyte membranes of swine
    G I Stangl
    Institut fur Ernahrungswissenschaften, Technische Universitat Munchen, Germany
    Eur J Nutr 38:271-7. 1999
    Conjugated linoleic acids (CLA)# refer to a group of linoleic acid (18:2)-derived isomers with conjugated double bonds mostly at carbon atoms 9 and 11 or 10 and 12, and with all possible cis and trans combinations...
  74. ncbi Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters
    Thomas A Wilson
    Department of Clinical Laboratory and Nutritional Sciences, Center for Health and Disease Research, University of Massachusetts Lowell, Lowell, Massachusetts 01854 5125, USA
    Lipids 41:41-8. 2006
    ..plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9,trans-11 CLA (9c,11 tCLA); trans-10,cis-12 CLA (10t,12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in ..
  75. ncbi Effects of trans-10, cis-12 conjugated linoleic acid on ovine milk fat synthesis and cheese properties
    L A Sinclair
    Animal Science Research Centre, Harper Adams University College, Edgmond, Newport, Shropshire, TF10 8NB, United Kingdom
    J Dairy Sci 90:3326-35. 2007
    Trans-10, cis-12 conjugated linoleic acid (CLA) reduces milk fat synthesis in sheep in a manner similar to that seen in dairy cows, but its effects on cheese yield and flavor are unknown...
  76. ncbi Conjugated linoleic acid modulation of cell membrane in leukemia cells
    Gerhard Agatha
    Friedrich Schiller University of Jena, Children s Hospital, Department of Pediatrics, Endocrinology and Metabolism, Kochstrasse 2, D 07745 Jena, Germany
    Cancer Lett 209:87-103. 2004
    This study compared the cellular uptake of pure conjugated linoleic acid isomers (CLA(9c,11t) and CLA(9c,11c)) to linoleic acid (LA) and their effects on polyunsaturated fatty acid (PUFA) synthesis, its metabolism into conjugated long ..
  77. ncbi One-week therapy with pantoprazole versus ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication
    J P Gisbert
    Department of Gastroenterology, Hospital de la Princessa, Universidad Autonoma de Madrid, Spain
    Eur J Gastroenterol Hepatol 12:489-95. 2000
    ..Our aim was to evaluate and to compare these two novel short-term triple therapies (Pan+Amo+Cla and RBC+Amo+Cla) for treatment of Helicobacter pylori.
  78. ncbi Evaluating the conjugated linoleic acid and trans 18:1 isomers in milk fat of dairy cows fed increasing amounts of sunflower oil and a constant level of fish oil
    C Cruz-Hernandez
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Alberta, 4 10 Agriculture Forestry Centre, Edmonton, Alberta, Canada, T6G 2P5
    J Dairy Sci 90:3786-801. 2007
    ..fat, and assess the content and composition of other trans-octadecenoic (trans-18:1) and conjugated linoleic acids (CLA) isomers...
  79. ncbi Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse
    M Yang
    Department of Animal Science, University of Wisconsin-Madison, 53706-1284, USA
    Immunopharmacol Immunotoxicol 22:433-49. 2000
    Conjugated linoleic acid (CLA) is a naturally occurring fatty acid with anti-carcinogenic, anti-atherosclerotic and immune-enhancing activities...
  80. ncbi [Recurrent respiratory tract infection caused by Moraxella catarrhalis in patients with pneumoconiosis]
    A Omori
    Department of Internal Medicine, Nagasaki University
    Kansenshogaku Zasshi 73:311-7. 1999
    ..Restriction enzyme analysis of chromosomal DNA by Hind III. Hae III, Cla I was performed on 50 strains of M. catarrhalis...
  81. pmc Effect of conjugated linoleic acids from beef or industrial hydrogenation on growth and adipose tissue characteristics of rats
    Mao L He
    Agriculture and Agri Food Canada, Lethbridge, Alberta, T1J 4B1, Canada
    Nutr Metab (Lond) 6:19. 2009
    ..abstract:..
  82. ncbi Conjugated linoleic acid and fish oil in laying hen diets: effects on egg fatty acids, thiobarbituric acid reactive substances, and tocopherols during storage
    G Cherian
    Department of Animal Sciences, Oregon State University, Corvallis 97331, USA
    Poult Sci 86:953-8. 2007
    The effects of incorporating conjugated linoleic acid (CLA) and fish oil in laying hen diets on egg CLA, n-3 fatty acid, tocopherol, and TBA reactive substances (TBARS) during 60 d of storage were investigated...
  83. ncbi Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage
    D U Ahn
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    Poult Sci 78:922-8. 1999
    ..5, or 5.0% conjugated linoleic acid (CLA). The diets were fed for 4 wk to determine the effect of dietary CLA on quality characteristics of eggs...
  84. ncbi Lipase-catalyzed fractionation of conjugated linoleic acid isomers
    M J Haas
    USDA, ARS, ERRC, Wyndmoor, Pennsylvania 19038, USA
    Lipids 34:979-87. 1999
    ..lipases produced by the fungus Geotrichum candidum to selectively fractionate mixtures of conjugated linoleic acid (CLA) isomers during esterification of mixed CLA free fatty acids and during hydrolysis of mixed CLA methyl esters were ..
  85. ncbi The effect of dietary conjugated linoleic acid on egg yolk fatty acids and hatchability in Japanese quail
    R Aydin
    Department of Animal Science, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
    Poult Sci 83:2016-22. 2004
    Conjugated linoleic acid (CLA) increased the ratio of saturated fatty acids to monounsaturated fatty acids in yolk and caused embryo mortality...
  86. doi Impairment of 8-iso-PGF(2ALPHA) isoprostane metabolism by dietary conjugated linoleic acid (CLA)
    Anna Iannone
    Universita degli Studi di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Via Campi 287, 41100 Modena, Italy
    Prostaglandins Leukot Essent Fatty Acids 80:279-87. 2009
    ..After its formation, it is promptly metabolized to 2,3 dinor (DIN) in peroxisomes. Conjugated linoleic acid (CLA) is preferentially beta-oxidized in peroxisomes which may compete with IP, and thereby may affect its metabolism...
  87. doi Comparative study of high-linoleic acid vegetable oils for the production of conjugated linoleic acid
    Whitney Gammill
    Department of Food Science, University of Arkansas, 2650 Young Avenue, Fayetteville, Arkansas 72704, USA
    J Agric Food Chem 58:2952-7. 2010
    Conjugated linoleic acid (CLA) is found in small quantities in dairy and beef products. Obtaining optimum dietary CLA levels from these sources requires an increased intake of saturated fat...
  88. doi Effects of dietary supplementation of rumen-protected conjugated linoleic acid to grazing cows in early lactation
    S R Medeiros
    Embrapa Beef Cattle, Campo Grande, Mato Grosso do Sul, Brazil
    J Dairy Sci 93:1126-37. 2010
    Conjugated linoleic acids (CLA) are potent anticarcinogens in animal and in vitro models as well as inhibitors of fatty acid synthesis in mammary gland, liver, and adipose tissue...
  89. doi Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates
    Cynthia M Magro
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Cutan Pathol 35:1040-9. 2008
    Cutaneous lymphocyte-associated antigen (CLA) is expressed in resident cutaneous T lymphocytes, high endothelial venules, peripheral monocytes, granulocytes and a small percentage of memory B cells...
  90. ncbi A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions
    Renata C O Zanardo
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
    Blood 104:3766-73. 2004
    ..In conclusion, E-selectin mediates PSGL-1-dependent and independent rolling and the latter can be down-regulated by systemic activation and can replace PSGL-1 to support the development of inflammation...
  91. ncbi Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition period
    L J Odens
    The Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Dairy Sci 90:293-305. 2007
    Supplementing a high dose of dietary conjugated linoleic acid (CLA) inhibits milk fat synthesis in dairy cows immediately postpartum...
  92. doi Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa
    Mamun M Or-Rashid
    Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Appl Microbiol Biotechnol 81:533-41. 2008
    ..study was designed to investigate the capability of mixed rumen protozoa to synthesize conjugated linoleic acid (CLA) from linoleic (LA) and vaccenic acids (VA). Rumen contents were collected from fistulated cows...
  93. ncbi The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects
    M M J W Kamphuis
    Department of Human Biology, Faculty of Health Sciences, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 27:840-7. 2003
    To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects after weight loss on weight regain, body composition, resting metabolic rate, substrate oxidation, and blood plasma parameters.
  94. doi Evidence that maternal conjugated linoleic acid negatively affects lipid uptake in late-stage chick embryos resulting in increased embryonic mortality
    V A Leone
    University of Wisconsin Madison, Animal Science Department, Madison, WI 53706, USA
    Poult Sci 89:621-32. 2010
    An experiment was performed to determine the effect of maternal dietary conjugated linoleic acid (CLA) on growth and composition of surviving chick embryos and residual yolk sacs during the last week of development when lipid utilization ..
  95. doi A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats
    A L Lock
    Department of Animal Science, University of Vermont, Burlington 05405, USA
    J Dairy Sci 91:3291-9. 2008
    The effect of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well described in dairy cows and sheep. Studies on lactating goats, however, remain inconclusive...
  96. ncbi The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese
    C Syvertsen
    Scandinavian Clinical Research AS, Kjeller, Norway
    Int J Obes (Lond) 31:1148-54. 2007
    Contradicting results have been published regarding the effect of conjugated linoleic acid (CLA) on insulin resistance...
  97. ncbi Trans-10,cis-12 conjugated linoleic acid suppresses the desaturation of linoleic and alpha-linolenic acids in HepG2 cells
    Klaus Eder
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr 132:1115-21. 2002
    The objective of this study was to determine the effects of cis-9,trans-11 and trans-10,cis-12 CLA on the fatty acid desaturation in a human hepatoma cell line, HepG2...
  98. ncbi Conjugated linoleic acid reduces adipose depots without reduction of stearoyl coenzyme A desaturase 1 gene expression
    Yun Hee Hwang
    Department of Food and Nutrition, College of Natural Sciences, Duksung Women s University, Seoul, Korea
    Ann Nutr Metab 51:126-33. 2007
    This study investigated the effects of conjugated linoleic acid (CLA) on the body weight, fat deposition and the expression of stearoyl coenzyme A desaturase 1 (SCD1) in the livers of male ICR mice that were fed with either beef tallow (..
  99. ncbi LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:1235-43. 2006
    Conjugated linoleic acids (CLA) have attracted scientific interest due to their potential beneficial effects on atherosclerosis...
  100. ncbi Utilization of oil by-product from the purification process of conjugated linoleic Acid as feeding supplements for the accumulation of conjugated linoleic acid in the egg yolk
    J H Kim
    Department of Food and Biotechnology, Korea University, Chungnam, Korea
    Poult Sci 87:64-70. 2008
    ..efficient way to use oil by-product which is obtained during the purification process of conjugated linoleic acid (CLA) from safflower oil. The CLA by-product (CBP) was fed to the laying hens to accumulate CLA in the egg yolk...
  101. ncbi Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs
    G Cherian
    Department of Animal Sciences, Oregon State University, Corvallis 97331 6702, USA
    Poult Sci 81:1571-7. 2002
    We investigated the effect of dietary conjugated linoleic acid (CLA) along with n-3 polyunsaturated fatty acid (n-3 PUFA) on yolk fatty acid composition and volatile compounds in eggs that were raw (RA), hard-boiled (HB), or hard-boiled, ..

Research Grants63

  1. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ..applicant): The major goal of this proposal is to investigate the mechanism of action of conjugated linoleic acids (CLA), the naturally occurring isomers of linoleic acid (LA), which have several unique physicochemical properties and ..
  2. Mechanisms of NaCl Absorption in the Human Colon
    Pradeep K Dudeja; Fiscal Year: 2013
    ..The outcome of these studies should define the role of HNFs in basal, inflammatory or CLA/DEX-mediated upregulation of DRA, and will also establish for the first time, the role of miRs in the modulation of ..
  3. Physiological Significance of Conjugated Double Bonds in Membrane Lipids
    Papasani Subbaiah; Fiscal Year: 2009
    ..to human health, a new class of naturally occurring trans fatty acids, called conjugated linoleic acids (CLA), which are found in dairy products and meat, have been shown to have several health benefits...
  4. Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation
    LAURA JANE DEN HARTIGH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Conjugated linoleic acid (CLA) is a natural dietary trans fatty acid reported to promote weight loss by unknown mechanisms...
  5. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..In animal models, S14 expression is inhibited by tolerable oral doses of conjugated linoleic acid (CLA), a popular dietary supplement and bioactive food component...
  6. Functional role of the Spot 14 gene in dietary regulation of milk fat synthesis
    KEVIN JOHN HARVATINE; Fiscal Year: 2013
    ..the functional role of Thyroid Hormone Responsive Spot 14 (S14) in trans-10, cis-12 conjugated linoleic acid (CLA) inhibition of milk fat synthesis we observed that the S14 null mouse was hyper-responsive to this bioactive FA...
  7. Synergistic effects of conjugated linoleic acid and calcium on bone mass
    Yeonhwa Park; Fiscal Year: 2009
    ..Conjugated linoleic acid (CLA) may be a good candidate for controlling osteoporosis based on the observation that CLA reduces body fat while ..
  8. Conjugated linoleic acid (CLA) promotes inflammation in human adipocytes
    KRISTINA BROOKE MARTINEZ; Fiscal Year: 2010
    ..One potential anti-obesity compound is conjugated linoleic acid (CLA), sold woridwide for weight loss...
  9. Fatty acid supplementation in management of type 2 diabetes
    Martha Belury; Fiscal Year: 2009
    ..R21 proposal is to develop a rigorous experimental approach for understanding the safety and efficacy for using CLA to complement TZD for improved management of type 2 diabetes...
  10. CLA Reduces Adipogenesis In Human Preadipocytes
    Michael McIntosh; Fiscal Year: 2001
    ..antiatherogenic, and hypocholesterolemic properties of a crude mixture of isomers of conjugated linoleic acid (CLA), an unsaturated fatty acid found in beef and dairy foods...
  11. CONJUGATED LINOLEIC AND OXIDATIVE LIPID METABOLISM
    ARTHUR BULL; Fiscal Year: 2001
    ..potential mechanisms of action by which a naturally occurring isomer of linoleic acid, conjugated linoleic acid (CLA), inhibits carcinogenesis...
  12. Benefits of conjugated linoleic acid on aging
    Gabriel Fernandes; Fiscal Year: 2007
    ..In recent years, there has been a growing interest in conjugated linoleic acid (CLA) as a possible dietary supplement to reduce obesity...
  13. Regulation of Adipose Tissue Inflammation by P-selectin Glycoprotein Ligand-1
    Daniel T Eitzman; Fiscal Year: 2013
    ..Identification of the cellular and molecular mediators of fat inflammation may lead to novel therapeutic agents aimed at reducing the risk of myocardial infarction and stroke in an overweight population. ..
  14. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..Specificity of effects will be tested using blocking antibodies to CLA-1 and known blockers of FSGS plasma effects...
  15. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..S. The drug being developed addresses a major unmet medical need for a therapy that can maintain remission and/or ameliorate the devastating effects of this disease. ..
  16. IMMUNE RESPONSES IN LUPUS
    Joseph Craft; Fiscal Year: 2013
    ..studies have demonstrated that Bcl6 is also required for downregulation of P-selectin glycoprotein ligand-1 (PSGL1), a surface protein on T cells that engages the chemokines CCL19 and CCL21 expressed in the T cell zone of ..
  17. Dermatotropic cellular immune responses induced by a novel smallpox vaccine
    Stephen R Walsh; Fiscal Year: 2013
    ..cells which express skin-tropic lymphocyte homing molecules, including the cutaneous lymphocyte-associated antigen (CLA) and specific chemokine receptors such as CCR4 and CCR10...
  18. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2012
    ..cycles of this grant, we have characterized the molecular structure and function of Cutaneous Lymphocyte Antigen or CLA. We have also made the surprising observation that in humans, the vast majority (>90 percent) of CLA+ skin ..
  19. Molecular Imaging of Ischemic Memory with Ultrasound - Transition to Humans
    Jonathan R Lindner; Fiscal Year: 2010
    ..The successful completion of our aims will lead to the development of a new strategy that can be used to more accurately diagnosis life-threatening coronary artery disease. ..
  20. Repair of DNA breaks in humans: the role of Rad54 protein
    Alexander V Mazin; Fiscal Year: 2013
    ..responsible for the repair of DNA double-strand breaks induced by ionizing radiation (IR) and cross-linking agents (CLA), which are commonly used in tumor therapy...
  21. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2011
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  22. Cellular Regulation of Selectin-Ligand Interactions
    RODGER PAUL MCEVER; Fiscal Year: 2013
    ..Because excessive recruitment of leukocytes contributes to many diseases, including heart attacks and strokes, understanding how cells regulate adhesion receptors may suggest new therapeutic strategies. ..
  23. DICHLOROACETATE KINETICS, METABOLISM AND TOXICOLOGY
    PETER STACPOOLE; Fiscal Year: 2009
    ..It is also employed as an investigational drug for treatment of congenital forms of lactic acidosis (CLA)...
  24. The role of neutrophil recruitment in arterial diseases
    Yuqing Huo; Fiscal Year: 2013
    ..These studies will provide evidence that inhibition of neutrophil recruitment to arteries is a viable approach to the prevention and treatment of arterial diseases. ..
  25. Novel Therapeutic Targets for Venous Thromboembolism
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2012
    ..abstract_text> ..
  26. Small Cell-Penetrating Glyco-Decoys Sidetrack Selectin Ligand Biosynthesis
    Khushi L Matta; Fiscal Year: 2013
    ..Among PSGL1, E selection and L selection, the latter is known to bind sulfated mucin-glycans...
  27. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    ..Our hope is that by understanding how thrombomodulin alters the activity of thrombin, we may be able to mimic this interaction with better pharmaceuticals that control hemostasis. ..
  28. Mechanisms for Blood Cell Adhesion Under Flow
    RODGER PAUL MCEVER; Fiscal Year: 2012
    ..This information obtained may offer new methods to treat excessive blood cell adhesion in heart attacks, strokes, deep venous thrombosis, and other disorders. ..
  29. Promoting genetic literacy in students and teachers: The effectiveness of non-cla
    LETA MEOLE TRIBBLE; Fiscal Year: 2010
    ....
  30. Immune Evasion in Human Squamous Cell Carcinomas of the Skin
    RACHAEL ANN CLARK; Fiscal Year: 2013
    ..neutralizes both of these defenses, inducing expression of E-selectin on tumor vessels, restoring the ability of CLA+ skin homing T cells to enter the tumor and reducing the % FOXP3+ Treg to levels found in normal skin...
  31. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..However, complications do occur, including central-line associated bloodstream infections (CLA-BSI), phlebitis, cellulitis, and thrombosis...
  32. Distinction of skin homing T cells that bind P-selectin
    Bruce Walcheck; Fiscal Year: 2004
    ..The cutaneous lymphocyte-associated antigen (CLA) distinguishes human T cells that selectively home to the skin...
  33. Modulating tolerance in a spontaneous mouse model of autoimmune vitiligo
    ISABELLE CAROLINE LE POOLE; Fiscal Year: 2013
    ..redirected towards the skin by overexpressing relevant skin homing receptors including but not limited to CCR-8 and CLA and/or chemokines such as CCL-1, in order to favor immune inhibition there where depigmentation is taking place...
  34. ADHESION MOLECULES IN TRANSFUSION BIOLOGY
    Denisa D Wagner; Fiscal Year: 2010
    ....
  35. A Novel B Cell Marker and Therapeutic Target in Lupus
    Joseph Craft; Fiscal Year: 2013
    ..Next, similar studies will be carried in lupus-prone mice, followed by blockade of PSGL1 interactions with its ligands, asking if PC trafficking to survival niches is altered, leading to diminished ..
  36. Regulation of Chronic Viral Infections
    LINDA MAC PHERSON BRADLEY; Fiscal Year: 2013
    ..On the basis of our findings we propose to investigate the mechanisms engaged by PSGL-1 to limit anti-viral immunity and explore therapeutic approaches to target this receptor to enhance anti-viral effector T cell responses ..
  37. Immunogenetic Mechanisms of Experimental Crohn's Disease
    Steven M Cohn; Fiscal Year: 2011
    ..The long-term goal of this Program Project is to understand the key pathogenic mechanisms of experimental CD, to aid development of a cure for at least a subgroup of patients with this devastating disease...
  38. Anaplasma - B. burgorferi/endothelijm interactions
    DENNIS GRAB; Fiscal Year: 2006
    ..to adhere to activated endothelial cells after significant loss of platelet selectin glycoprotein ligand (PSGL)-1 (CD162) and L-selectin (CD62L) adhesion molecule expression...
  39. MOLECULAR BASIS OF T CELL HOMING TO INFLAMED SKIN
    Louis Picker; Fiscal Year: 1999
    ..T cells that express the skin-selective homing receptor (HR), cutaneous lymphocyte associated antigen (CLA)...
  40. DRUG RESISTANCE AND GENE TRANSFER IN H PYLORI
    Douglas Berg; Fiscal Year: 2003
    ..The two most widely used types of therapies against HP depend on metronidazole (Mtz) or clarithromycin (Cla), in combination with other agents, but resistance (R) to Mtz is common, and CIaR is also known...
  41. MOLECULAR ANALYSIS OF MUCIN TYPE O GLYCOSYLATION
    Michael Hollingsworth; Fiscal Year: 2000
    ....
  42. Role of Vascular Heterogeneity in Thrombosis
    Barbara Furie; Fiscal Year: 2006
    ..abstract_text> ..
  43. Selectin Control of Leukocyte Adhesion in Shear
    Michael Lawrence; Fiscal Year: 2006
    ..Such insight may lead to identification of more effective molecular targets for anti-inflammatory therapeutics. ..
  44. Vitamins help regulate the expression of trafficking receptors on T cells.
    Hekla Sigmundsdottir; Fiscal Year: 2007
    ..The effects of vitamin D and vitamin A (and interactions between them) on homing receptors for skin (CLA, CCR4), the epidermis (CCR10), and the gut will be assessed...
  45. P SELECTIN LIGAND ON HUMAN T CELL
    Kevin Moore; Fiscal Year: 1999
    ..These studies should provide new insights into the molecular mechanisms for P-selectin interaction with lymphoid cells and the potential role of P-selectin in the recruitment of lymphoid cells into sites of inflammation. ..
  46. Structure/Function of the Selectin Ligand PSGL-1
    Richard Cummings; Fiscal Year: 2005
    ..Such an understanding will directly contribute to the control and treatment of inflammatory diseases and should have broad implications for other types of glycobiological interactions. ..
  47. Identification of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2006
    ..Furthermore, it will identify novel targets for preventing and treating HGA and may pave the way for development of pharmacologic inhibitors of cellular adhesion events associated with disease. ..
  48. ROLE OF FUCOSYLTRANSEFERASE IN ANTIVIRAL CYTOTOXICITY
    MANJUNATH SWAMY; Fiscal Year: 2000
    ..If such molecule exists, we will isolate, clone, and characterize the molecule. ..
  49. PEGylation of a Glycosulfopeptide Anti-Inflammatory
    ZIAD KAWAR; Fiscal Year: 2004
    ..This work will lead to a SBIR Phase II application to use PEG-Glysopep in animal models of disease in preparation for filing an Investigational New Drug application with the Food and Drug Administration. ..
  50. Molecular Basis For Functional Diversity Of PSGL-1
    KAREN SNAPP; Fiscal Year: 2005
    ....
  51. E-SELECTIN LIGANDS ON LYMPHOCYTES
    Mark Jutila; Fiscal Year: 2001
    ..The results of these studies may reveal new approaches to development of specific inhibitors that can selectively target neutrophil versus lymphocyte recruitment to sites of inflammation involving either P-selectin or E-selectin. ..
  52. Selectins and their ligands in leukocyte trafficking
    Erik Vandendries; Fiscal Year: 2005
    ....
  53. ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUM
    DOUGLAS GOETZ; Fiscal Year: 2003
    ..abstract_text> ..
  54. MOLECULAR BASIS OF SELECTIN INTERACTIONS WITH LEUKOCYTES
    RODGER MCEVER; Fiscal Year: 2004
    ..These studies will provide new insigrhts into the mechanisms by which selectins initiate leukocyi:e adhesion in shear flow. ..
  55. MOLECULAR STUDIES OF ERYTHEMA MULTIFORME
    Laure Aurelian; Fiscal Year: 2004
    ..T cell clones and PBMC from HAEM and HSV patients will be examined for the presence of the skin homing receptor CLA. The second aim (II) is to examine the role of Pol in epidermal damage by determining(a) expression of the Pol ..
  56. Kinetic Analysis of the PSGL-1 Molecule
    Cheng Zhu; Fiscal Year: 2004
    ..It may also provide guidance to the development of PSGL-1 and/or selectin-based drugs for treatment of inflammatory and thrombotic disorders. ..
  57. KINETIC PROPERTIES OF SELECTINS
    Cheng Zhu; Fiscal Year: 2000
    ....
  58. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2003
    ..to production of chemokines and induction of endothelial adhesion molecules in dermis that specifically recruit CLA+, or skin homing T cells in an antigen-independent fashion...
  59. Inhibition of leukocyte C2GlcNAcT--l reduces thrombosis
    Yuqing Huo; Fiscal Year: 2007
    ..Inhibition of C2GIcNAcT-I may be a novel approach for preventive and therapeutic interventions in arterial thrombosis in atherosclerosis. ..
  60. ROLE OF FUCOSYLTRANSFERASE IN ANTIVIRAL CYTOTOXICITY
    MANJUNATH SWAMY; Fiscal Year: 2004
    ..Indeed, we have identified such a counter-receptor on activated T cells using soluble recombinant PSGL-1 tetramers. Thus in Aim 3, we will isolate, clone and characterize the molecule. ..
  61. Endothelial Regulation of Leukocyte Transmigration
    FRANCIS LUSCINSKAS; Fiscal Year: 2009
    ..abstract_text> ..
  62. CCR4 IN SKIN LYMPHOCYTE HOMING AND IMMUNITY
    James Campbell; Fiscal Year: 2000
    ..circulating systemic memory T cells, especially skin-homing T cells expressing the cutaneous lymphocyte antigen, CLA. In contrast, intestinal (alpha4beta7+) memory and naive T cells respond poorly...
  63. Mechanisms of HSV-2-Specific CD4 T-cell Homing
    Julio Gonzalez; Fiscal Year: 2007
    ..Our lab has shown that HSV-2-specific CD8 T-cells selectively express CLA, a molecule related to a functional E-selectin ligand (ESL), and that vascular E-selectin is up-regulated in the ..