SEEK1

Summary

Gene Symbol: SEEK1
Description: psoriasis susceptibility 1 candidate 1
Alias: C6orf16, SEEK1, psoriasis susceptibility 1 candidate gene 1 protein
Species: human

Top Publications

  1. pmc Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis
    Paola Conigliaro
    Clinic of Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 12:e0169956. 2017
  2. pmc Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis
    C Ciccacci
    Department of Biomedicine and Prevention, Genetics Section, Rome, Italy
    Clin Exp Immunol 186:157-163. 2016
  3. doi A polymorphism within the psoriasis susceptibility 1 candidate 1 (PSORS1C1) gene is not linked to HLA-B*58:01 in an Australian cohort
    C Vidal
    Immunorheumatology Laboratory, Pathology North Northern Sydney, St Leonards, Australia Electronic address
    Drug Metab Pharmacokinet 31:252-5. 2016
  4. pmc A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene
    Cinzia Ciccacci
    Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 9:e111991. 2014
  5. pmc Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease)
    Zhihui Xie
    Molecular Signal Transduction Section NIAID NIH Bethesda, MD USA
    Rare Dis 1:. 2013
  6. pmc Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study
    Joshua M Galanter
    Department of Medicine, University of California, San Francisco, Calif Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif Electronic address
    J Allergy Clin Immunol 134:295-305. 2014
  7. doi HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique
    Paola Borgiani
    Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Eur J Clin Pharmacol 70:275-8. 2014
  8. doi Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease
    T Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Clin Genet 86:383-6. 2014
  9. pmc Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
    Daniel Chubb
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK 2
    Nat Genet 45:1221-5. 2013
  10. pmc Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study
    Lara Bossini-Castillo
    Department of Immunology, Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Consejo Superior de Investigaciones Cientificas, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n 18100 Armilla, Granada, Spain
    Ann Rheum Dis 72:602-7. 2013

Scientific Experts

  • Joshua Galanter
  • Paola Borgiani
  • C Vidal
  • Emmanuelle Genin
  • Lara Bossini-Castillo
  • P Rahman
  • Y T Chang
  • Y Allanore
  • Rohina Rubicz
  • Cinzia Ciccacci
  • Paola Conigliaro
  • C Ciccacci
  • Giuseppe Novelli
  • Sara Rufini
  • Carlo Perricone
  • T Wada
  • Hongjun Sun
  • Zhihui Xie
  • M Tohkin
  • Daniel Chubb
  • Travis Hughes
  • Keiko Maekawa
  • Shengping Hou
  • Weiliang Qiu
  • Yee Him Cheung
  • Sophie Limou
  • Jae Jung Kim
  • Rajan P Nair
  • Lynette Peddle
  • Atsuko Shigenari
  • Cristina Politi
  • Roberto Perricone
  • Barbara Kroegler
  • Paola Triggianese
  • Andrea Latini
  • R Perricone
  • C Perricone
  • P Triggianese
  • S Rufini
  • Sofia J Holm
  • G Novelli
  • C Politi
  • P Conigliaro
  • Davide Di Fusco
  • Fabrizio Conti
  • Francesca Romana Spinelli
  • Guido Valesini
  • Fulvia Ceccarelli
  • K Takehara
  • T Toma
  • Cristiano Alessandri
  • Y Matsuda
  • M Muraoka
  • A Yachie
  • M Fujimoto
  • Enrica Cipriano
  • Thomas W Mühleisen
  • Y Saito
  • Y Takahashi
  • Richard S Houlston
  • K Kurose
  • Cisca Wijmenga
  • Javier Gutierrez-Achury
  • Stephen F Porcella
  • Dirk Hose
  • Haner Direskeneli
  • Asta Forsti
  • S Kinoshita
  • Guy Pratt
  • Sara E Dobbins
  • M Aihara
  • Guher Saruhan-Direskeneli
  • James M Allan
  • Celeste M Nelson
  • Bowang Chen
  • J Nishikawa
  • Adam Adler
  • Kenan Aksu
  • James A L Fenton
  • Z Ikezawa
  • David C Johnson
  • Yuejian Wang
  • Gabriele Migliorini
  • Kari Hemminki
  • Amy Holroyd
  • Kirk M Druey
  • Peter Broderick
  • Markus M Nothen
  • Christian Langer
  • Hartmut Goldschmidt

Detail Information

Publications30

  1. pmc Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis
    Paola Conigliaro
    Clinic of Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 12:e0169956. 2017
    ..We aimed at exploring 4 SNPs in candidate genes (STAT4, PTPN2, PSORS1C1 and TRAF3IP2) in order to investigate their potential role in the response to therapy with tumor necrosis factor inhibitors (TNF-i) in RA patients...
  2. pmc Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis
    C Ciccacci
    Department of Biomedicine and Prevention, Genetics Section, Rome, Italy
    Clin Exp Immunol 186:157-163. 2016
    ..For the first time, we described that SNPs in PSORS1C1, PTPN2 and MIR146A genes were associated differently with a severe disease phenotype in terms of autoantibody status and radiographic damage in an Italian RA population...
  3. doi A polymorphism within the psoriasis susceptibility 1 candidate 1 (PSORS1C1) gene is not linked to HLA-B*58:01 in an Australian cohort
    C Vidal
    Immunorheumatology Laboratory, Pathology North Northern Sydney, St Leonards, Australia Electronic address
    Drug Metab Pharmacokinet 31:252-5. 2016
    ..The aim of this study is to confirm whether this polymorphism can be used as a surrogate biomarker to identify carriers for HLA-B*58:01. No linkage was found between the two in the Australian cohort. ..
  4. pmc A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene
    Cinzia Ciccacci
    Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 9:e111991. 2014
    ....
  5. pmc Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease)
    Zhihui Xie
    Molecular Signal Transduction Section NIAID NIH Bethesda, MD USA
    Rare Dis 1:. 2013
    ..These results highlight SNPs with potential relevance to SCLS...
  6. pmc Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study
    Joshua M Galanter
    Department of Medicine, University of California, San Francisco, Calif Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif Electronic address
    J Allergy Clin Immunol 134:295-305. 2014
    ..Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent...
  7. doi HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique
    Paola Borgiani
    Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Eur J Clin Pharmacol 70:275-8. 2014
    ..Our aim was to verify the contribution of these two genes in the susceptibility to NVP-induced SJS/TEN in a population from Mozambique...
  8. doi Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease
    T Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Clin Genet 86:383-6. 2014
    ..These results suggest an Alu-mediated recombination event as the mechanism underlying the deletion in our patient. ..
  9. pmc Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
    Daniel Chubb
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK 2
    Nat Genet 45:1221-5. 2013
    ..67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition. ..
  10. pmc Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study
    Lara Bossini-Castillo
    Department of Immunology, Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Consejo Superior de Investigaciones Cientificas, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n 18100 Armilla, Granada, Spain
    Ann Rheum Dis 72:602-7. 2013
    ..The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry...
  11. doi PSORS1C1 may be involved in rheumatoid arthritis
    Hongjun Sun
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, PR China
    Immunol Lett 153:9-14. 2013
    ..PSORS1C1-siRNA treatment significantly decreased the PSORS1C1 expression, IL-17 level, Il-1β level and cell proliferation in RASF. These results suggest that PSORS1C1 might play an important role in the development of RA...
  12. doi Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease
    Travis Hughes
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 45:319-24. 2013
    ..01, P = 3.01 × 10(-26)), upstream of HLA-F-AS1 (rs114854070: OR = 1.95, P = 7.84 × 10(-14)) and with HLA-Cw*1602 (OR = 5.38, P = 6.07 × 10(-18)) were also identified and replicated...
  13. pmc A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1)
    Rohina Rubicz
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
    PLoS Genet 9:e1003147. 2013
    ..The significance of this work is that a major locus related to EBV infection has been identified, which may ultimately reveal the underlying mechanisms by which the immune system regulates infection with this pathogen...
  14. doi Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study
    Shengping Hou
    The First Affiliated Hospital of Chongqing Medical University and Chongqing Key Laboratory of Ophthalmology, Chongqing, China
    Arthritis Rheum 64:4104-13. 2012
    ..To identify susceptibility loci for Behçet's disease (BD) and elucidate their functional role...
  15. ncbi Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese
    Keiko Maekawa
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 27:447-50. 2012
    ..This robust and inexpensive assay would be useful for pre-screening the subjects with HLA-B*58:01, a genetically high risk factor for allopurinol-induced SJS/TEN...
  16. doi A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    M Tohkin
    Department of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Pharmacogenomics J 13:60-9. 2013
    ..The ease of typing rs9263726 makes it a useful biomarker for allopurinol-related SJS/TEN in Japanese...
  17. pmc Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
    Emmanuelle Genin
    INSERM U, Paris, France
    Orphanet J Rare Dis 6:52. 2011
    ..Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described...
  18. ncbi Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene
    A Oka
    Department of Genetic Information, Tokai University School of Medicine, Bohseidai, Kanagawa, Japan
    Hum Mol Genet 8:2165-70. 1999
    ..Therefore, these seven genes are the potential candidates for susceptibility to psoriasis vulgaris...
  19. pmc Genetics of sputum gene expression in chronic obstructive pulmonary disease
    Weiliang Qiu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24395. 2011
    ..Integrative analysis of GWAS and gene expression data from relevant tissue from diseased subjects has located potential functional variants in two known COPD genes and has identified a novel COPD susceptibility locus...
  20. pmc Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    Yannick Allanore
    Universite Paris Descartes, Rhumatologie A, INSERM, U1016, Hopital Cochin, APHP, Paris, France
    PLoS Genet 7:e1002091. 2011
    ..The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis...
  21. pmc Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC
    Yee Him Cheung
    Department of Electrical Engineering, Center for Computational Biology and Bioinformatics, Columbia University, 1300 S W Mudd, 500 West 120th Street, New York, NY 10027, USA
    Hum Genet 129:161-76. 2011
    ..66 × 10(-11) and rs2523619, p = 2.77 × 10(-10) conditional on the DR/DQ genotypes). A subsequent LD analysis established TCF19, POU5F1, CCHCR1 and PSORS1C1 as potential causal genes for the observed association...
  22. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  23. doi Genetic variants in the HLA-G region are associated with Kawasaki disease
    Jae Jung Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
    Hum Immunol 69:867-71. 2008
    ..02, 95% CI = 1.23-13.19). Therefore, our results indicate that HLA-G may play a crucial role for the susceptibility to Kawasaki disease...
  24. pmc Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene
    Rajan P Nair
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0932, USA
    Am J Hum Genet 78:827-51. 2006
    ..SPR1 and SEEK1 both had messenger RNA alleles specific to risk haplotypes, but only HLA-C and CDSN yielded protein alleles unique ..
  25. ncbi A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis
    Y T Chang
    Department of Dermatology, National Yang Ming University, Taipei, Taiwan, Republic of China
    Br J Dermatol 153:90-6. 2005
    ..The psoriasis susceptibility 1 candidate 1 (PSORS1C1, formerly SEEK1) gene, located 127 kb telomeric to the HLA-C locus, is considered to be one of the potential candidate genes of ..
  26. pmc Association of SEEK1 and psoriatic arthritis in two distinct Canadian populations
    P Rahman
    St Clare s Mercy Hospital, Memorial University of Newfoundland, 1 South 154 LeMarchant Rd, St John s, Newfoundland, Canada A1C 5B8
    Ann Rheum Dis 64:1370-2. 2005
    To examine the relationship between SNP +39604 in SEEK1 and psoriatic arthritis (PsA) in two distinct Canadian populations.
  27. ncbi Association of SEEK1 polymorphisms in Crohn's disease
    Lynette Peddle
    Newfound Genomics, Memorial University of Newfoundland, Nefoundland A1C 5B8, Canada
    Hum Immunol 65:706-9. 2004
    ..Recent studies have postulated similarities in genetic susceptibility of CD and psoriasis. Because the +39604 SEEK1 polymorphism in chromosome 6p has recently been associated with psoriasis, the prevalence of this polymorphism, as ..
  28. ncbi Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clusters
    Atsuko Shigenari
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, 259 1193, Kanagawa, Japan
    Immunogenetics 55:695-705. 2004
    ..the corresponding human genes were identified, with the gene order from the centromere to telomere of HCR - SPR1 - SEEK1 - CDSN - STG - DPCR1 - KIAA1885 - TFIIH - DDR - IER3 - FLOT1 - TUBB - KIAA0170 - NRM - KIAA1949 - DDX16 - FLJ13158 ..
  29. ncbi Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population
    Sofia J Holm
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Exp Dermatol 12:435-44. 2003
    ..We have characterized two overlapping genes, SEEK1 and SPR1...