SDF2L1

Summary

Gene Symbol: SDF2L1
Description: stromal cell derived factor 2 like 1
Alias: stromal cell-derived factor 2-like protein 1, PWP1-interacting protein 8, SDF2-like 1, SDF2-like protein 1, dihydropyrimidinase-like 2
Species: human

Top Publications

  1. doi Mapping wild-type and R345W fibulin-3 intracellular interactomes
    John D Hulleman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA Electronic address
    Exp Eye Res 153:165-169. 2016
  2. pmc Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction
    Katarzyna K Krawczyk
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Rep 6:32449. 2016
  3. pmc Three interacting genomic loci incorporating two novel mutations underlie the evolution of diet-induced diabetes
    Yoram Yagil
    Laboratory for Molecular Medicine and Israeli Rat Genome Center, Barzilai University Medical Center, Ashkelon
    Mol Med 22:. 2016
  4. doi Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes
    Chun lei Liu
    Department of Geriatric Cardiology, The General Hospital of Chinese People s Liberation Army, No 28, FuXing Road, Haidian District, Beijing, 100853, China
    Mol Cell Biochem 413:57-67. 2016
  5. pmc Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans
    Hwayoung Lee
    Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea
    Int J Mol Med 35:1574-86. 2015
  6. doi Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors
    Brenda Luna
    Department of Environmental and Occupational Health, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA
    Mol Neurobiol 52:1341-63. 2015
  7. doi Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse
    Aline R Lorenzon-Ojea
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Int J Biochem Cell Biol 53:262-70. 2014
  8. ncbi Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice
    H Fai Poon
    Department of Chemistry, Center of Mambrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1010-9. 2006
  9. doi SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
    Akansha Tiwari
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, ON M5G 1L7, Canada
    J Cell Sci 126:1962-8. 2013
  10. doi CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients
    Patrícia Natalia Silva
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, Sao Paulo SP, Brazil
    J Alzheimers Dis 33:349-55. 2013

Research Grants

  1. Post-translational processing of myeloid alpha-defensins.
    PRASAD C TONGAONKAR; Fiscal Year: 2010

Scientific Experts

  • John D Hulleman
  • O Carrette
  • Prasad Tongaonkar
  • Shinji Oikawa
  • Daniel Martins-de-Souza
  • Takayoshi Koide
  • Yoshiaki Tsuboko
  • Karin Berg
  • Hak Jae Kim
  • Katarzyna K Krawczyk
  • Chun lei Liu
  • Yoram Yagil
  • Brenda Luna
  • Hwayoung Lee
  • Radhika A Vaishnav
  • H Fai Poon
  • Aline R Lorenzon-Ojea
  • Akansha Tiwari
  • Patrícia Natalia Silva
  • Rongcai Yue
  • Karlfried Groebe
  • Yun Hui Zhang
  • Hua Kang
  • James D Bortner
  • Fransisca Indraswari
  • A Tsolakidou
  • Yi Qiong Zhang
  • D Allan Butterfield
  • Marilyn L Getchell
  • Thomas V Getchell
  • Xinzhi Zhao
  • Christiane Bies
  • Karl Swärd
  • Mari Ekman
  • Xin Li
  • Chana Yagil
  • Song Li
  • Refael Kohen
  • Yun Yun He
  • Kun Lun He
  • Sebastian Albinsson
  • Wu Zhong
  • Mario Grossi
  • Bengt Uvelius
  • Catarina Rippe
  • Kenji Nakata
  • Bengt Olof Nilsson
  • Barak Markus
  • Hyung Ki Kim
  • Jayakar Prasanna
  • Ian Miller
  • Ziad Khatib
  • Seong Su Nah
  • Quentin Felty
  • David I Sandberg
  • Deodutta Roy
  • Hwa Young Lee
  • Jong Woo Kim
  • Changwon Yoo
  • Sanjiv Bhatia
  • Jun Tack Kwon
  • Michael Duchowny
  • Jaesoon Joo
  • John Ragheb
  • Young Ock Kim
  • Susan J Fisher
  • Estela Bevilacqua
  • Alberto F Ribeiro
  • Cristiane R Guzzo
  • Waldir Caldeira
  • Marília Cardoso Smith
  • Naguib Mechawar
  • Emma M Allister
  • Elizabeth Suchi Chen
  • Roger Willian de Labio
  • Paulo Henrique Bertolucci
  • Allen Volchuk
  • Irmgard Schuiki
  • Spencer Luiz Payão
  • Tatiane Katsue Furuya
  • Liling Zhang
  • Ianna Sampaio Braga
  • Michael B Wheeler
  • Jonathan Mill
  • Gustavo Turecki
  • Lucas Trevizani Rasmussen
  • Peng Jiang
  • Jigang Zhang
  • Xing Yuan
  • Lei Shan

Detail Information

Publications31

  1. doi Mapping wild-type and R345W fibulin-3 intracellular interactomes
    John D Hulleman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA Electronic address
    Exp Eye Res 153:165-169. 2016
    ..Eight of these interactions (ANXA5, ERdj5, PDIA4, P4HB, PDIA6, RCN1, SDF2L1, and TXNDC5) were verified at the western blotting level...
  2. pmc Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction
    Katarzyna K Krawczyk
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Sci Rep 6:32449. 2016
    ..Downstream of ATF6α, Calr, Manf, Sdf2l1 and Pdi increased as did ER size, whereas contractile markers were reduced...
  3. pmc Three interacting genomic loci incorporating two novel mutations underlie the evolution of diet-induced diabetes
    Yoram Yagil
    Laboratory for Molecular Medicine and Israeli Rat Genome Center, Barzilai University Medical Center, Ashkelon
    Mol Med 22:. 2016
    ..analysis that consisted of a novel high impact deletion on RNO11 that was unique to CDs/y and that involved the Sdf2l1 gene...
  4. doi Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes
    Chun lei Liu
    Department of Geriatric Cardiology, The General Hospital of Chinese People s Liberation Army, No 28, FuXing Road, Haidian District, Beijing, 100853, China
    Mol Cell Biochem 413:57-67. 2016
    ..Six not well-known genes (Hyou1, Herpud1, Manf, Creld2, Sdf2l1, and Slc3a2) were highlighted to be involved in ER stress...
  5. pmc Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans
    Hwayoung Lee
    Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea
    Int J Mol Med 35:1574-86. 2015
    ....
  6. doi Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors
    Brenda Luna
    Department of Environmental and Occupational Health, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA
    Mol Neurobiol 52:1341-63. 2015
    ....
  7. doi Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse
    Aline R Lorenzon-Ojea
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Int J Biochem Cell Biol 53:262-70. 2014
    ..In human and mouse, Sdf2 has a paralogous gene, Sdf2l1, whose protein sequences are 78% similar and 68% identical...
  8. ncbi Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice
    H Fai Poon
    Department of Chemistry, Center of Mambrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1010-9. 2006
    ..Our results establish an initial basis for understanding protein alterations that may lead to age-related cellular dysfunction in the brain...
  9. doi SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells
    Akansha Tiwari
    Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, ON M5G 1L7, Canada
    J Cell Sci 126:1962-8. 2013
    Stromal cell-derived factor 2-like 1 (SDF2L1) is an endoplasmic reticulum (ER)-localized protein whose function is undefined...
  10. doi CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients
    Patrícia Natalia Silva
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, Sao Paulo SP, Brazil
    J Alzheimers Dis 33:349-55. 2013
    ..No AD-associated differences in CNP and DPYSL2 promoter DNA methylation were observed, suggesting that other mechanisms may be involved in mediating the observed CNP gene expression...
  11. doi Cynandione A mitigates ischemic injuries in rats with cerebral ischemia
    Rongcai Yue
    School of Pharmacy, Second Military Medical University, Shanghai, China
    J Neurochem 121:451-64. 2012
    ..2% reduction in cerebral infarction size at 72 h (p < 0.05 vs. control). Our findings demonstrated that cynandione A mitigated ischemic injuries and should be further explored as a neuroprotective agent for ischemic stroke...
  12. doi Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia
    Daniel Martins-de-Souza
    Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstr 2, 80804 Munich, Germany
    J Psychiatr Res 44:989-91. 2010
    ..Our findings not only support previous findings but also indicate areas that warrant further study in schizophrenia...
  13. doi Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153
    Karin Berg
    Department of Molecular Biology, University of Bergen, PB 7803, N 5020 Bergen, Norway
    Aquat Toxicol 105:206-17. 2011
    ..Our findings constitute novel clues for further research on PCB 153 mode of action in brain, and a proper selection of proteins may, following validation, be applicable in a panel of biomarkers for aquatic environmental monitoring...
  14. ncbi Propofol anaesthesia alters the cerebral proteome differently from sevoflurane anaesthesia
    Yoshiaki Tsuboko
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    Biomed Res 32:55-65. 2011
    ..This study highlights the power of proteomic studies in assessing the effects of certain anaesthetics on the integrity of neuronal structure and function...
  15. doi Protein biomarkers for in vitro testing of embryotoxicity
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Str 51, D 55129 Mainz, Germany
    J Proteome Res 9:5727-38. 2010
    ..On the other hand, Heat shock protein 8 and Fscn1 protein were down-regulated by all compounds from both clusters...
  16. ncbi [Changes of proteomics in the lung of rats subjected to acrolein inhalation after enalapril administration]
    Yun Hui Zhang
    People s Hospital of Yunnan Province, Kunming 65000, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 41:273-5, 279. 2010
    ..To study the molecular mechanism of enalapril on rat chronic bronchopneumonia model with proteomics method...
  17. doi A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
    ..39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects...
  18. ncbi Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family
    S Fukuda
    Second Department of Surgery, Department of Urology, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 0037, Japan
    Biochem Biophys Res Commun 280:407-14. 2001
    We isolated murine and human cDNAs for SDF2L1 (stromal cell-derived factor 2-like1) and characterized the genomic structures...
  19. doi Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach
    Hak Jae Kim
    Kohwang Medical Research Institute, Kyung Hee University, Seoul 130 701, Korea
    Neurol Res 32:69-73. 2010
    ..To identify new proteins on acupuncture effects in maternally separated rats, an animal model for study of early environmental insults, proteomic approach on the expression of the hypothalamic proteins was performed...
  20. pmc Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis
    James D Bortner
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Proteome Res 8:4050-61. 2009
    ..Identification of these proteins in surrogate tissue in future studies would be highly useful in early detection of lung adenocarcinoma and clinical chemoprevention trials...
  21. doi Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke
    Fransisca Indraswari
    Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore
    Neurochem Int 55:235-42. 2009
    ....
  22. ncbi Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer
    Hua Kang
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Oncol 35:205-11. 2009
    ..These SDFs thus have prognostic value and warrant further investigation in their biological functions and clinical value...
  23. doi Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Free Radic Biol Med 46:1472-7. 2009
    ..Therefore, ischemia-reperfusion-induced oxidative damage to these proteins in the CA1 may lead to loss of the neuroprotective function, which contributes to neuronal death...
  24. pmc SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides
    Prasad Tongaonkar
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 284:5602-9. 2009
    ..for a yeast two-hybrid screen that identified rhesus macaque stromal cell-derived factor 2-like protein 1 (SDF2L1), as an interactor...
  25. doi Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways
    A Tsolakidou
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804, Munich, Germany
    Mol Cell Neurosci 38:444-52. 2008
    ..Furthermore, we focused in particular on dihydropyrimidinase like 2, to which we provide evidence for its regulation by NeuroD, an important factor for neuronal activity-..
  26. ncbi [Effect of low dose radiation on human [corrected] bone marrow mesenchymal stem cells by using proteomic analysis]
    Yi Qiong Zhang
    Department of Hematology and Onocology, The First Clinical Hospital, Jilin University, Changchun 130021, Jilin Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:151-5. 2008
    ..The study provides some new explanation for the mechanism of low dose radiation injury...
  27. ncbi Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization
    Radhika A Vaishnav
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 85:373-85. 2007
    ..These results indicate that specific carbonylated proteins, including those in astrocytes and mitral/tufted neurons, and nitrated proteins in the vasculature are molecular substrates of age-related olfactory dysfunction...
  28. ncbi Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease
    O Carrette
    Neuroproteomics Group, Department of Structural Biology and Bioinformatics, Geneva University, Faculty of Medicine, Geneva, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 840:1-9. 2006
    ..These proteins and their modification probably play a role in the amyloid aggregate formation in these mice...
  29. ncbi An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Int J Neuropsychopharmacol 9:705-12. 2006
    ....
  30. ncbi Characterization of pancreatic ERj3p, a homolog of yeast DnaJ-like protein Scj1p
    Christiane Bies
    Medizinische Biochemie and Molekularbiologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    Biol Chem 385:389-95. 2004
    ..Furthermore, we found that ERj3p interacts with SDF2L1 protein that may be involved in protein O-glycosylation...
  31. ncbi The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia
    Kenji Nakata
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Biol Psychiatry 53:571-6. 2003
    ..In addition, the DRP-2 gene (Dihydropyrimidinase-like 2; DPYSL2) is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies...

Research Grants1

  1. Post-translational processing of myeloid alpha-defensins.
    PRASAD C TONGAONKAR; Fiscal Year: 2010
    ..Using recombinant prodefensins as "bait" in yeast two-hybrid experiments, we identified SDF2L1 a component of an endoplasmic reticulum (ER) chaperone complex to be a key element in defensin biosynthesis...