SCUBE1

Summary

Gene Symbol: SCUBE1
Description: signal peptide, CUB domain and EGF like domain containing 1
Alias: signal peptide, CUB and EGF-like domain-containing protein 1, signal peptide, CUB domain, EGF-like 1, signal peptide-CUB domain-EGF-related 1
Species: human

Top Publications

  1. ncbi Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, United Kingdom
    Genomics 70:74-81. 2000
  2. doi Disruption of Scube2 Impairs Endochondral Bone Formation
    Yuh Charn Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Bone Miner Res 30:1255-67. 2015
  3. doi Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH)
    Jan Kuhnisch
    Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig Maximilians University of Munich, Goethestraße70, Munich, 80336, Germany
    Clin Oral Investig 18:677-82. 2014
  4. ncbi Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis
    Hirowati Ali
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 59:E122-31. 2013
  5. doi Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis
    Meng Ying Wu
    From the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan M Y W, Y C L, W J L, R B Y Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan M Y W, Y C L, W J L, C F T, S R R, R B Y Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan C F T Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan C F T Department of Applied Statistics and Information Science, Ming Chuan University, Taoyuan, Taiwan M H C and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan R B Y
    Arterioscler Thromb Vasc Biol 34:1390-8. 2014
  6. doi The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome
    Ertan Sönmez
    Bezmialem Vakif University, Department of Emergency Medicine, Istanbul, Turkey Electronic address
    Am J Emerg Med 33:21-4. 2015
  7. doi Is signal peptide-CUB-EGF domain-containing protein1 a diagnostic biomarker in patients with hypertensive crises
    Mustafa Karabacak
    Department of Cardiology, Isparta State Hospital, Isparta, Turkey
    Clin Hemorheol Microcirc 61:513-22. 2015
  8. doi Diagnostic value of plasma signal peptide-Cub-Egf domain-containing protein-1 (SCUBE-1) in an experimental model of acute ischemic stroke
    Suha Turkmen
    Karadeniz Technical University, Faculty of Medicine, Department of Emergency Medicine, Trabzon, Turkey
    Am J Emerg Med 33:262-5. 2015
  9. doi The role of hypoxia at primary dysmenorrhea, utilizing a novel hypoxia marker--SCUBE1
    Yeşim Bayoğlu Tekin
    Department of Gynecology and Obstetrics, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey Electronic address
    J Pediatr Adolesc Gynecol 28:63-5. 2015
  10. doi The Diagnostic Value of Plasma SCUBE1, a Novel Biomarker of Platelet Activation, in Testicular Torsion: A Randomized, Controlled, Experimental Study
    Suleyman Turedi
    Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey Electronic address
    Urology 86:516-20. 2015

Research Grants

  1. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009

Scientific Experts

  • J Kuhnisch
  • Suleyman Turedi
  • Yesim Bayoglu Tekin
  • Qi Han Chen
  • Sukru Ulusoy
  • Stella Aslibekyan
  • John Heit
  • Amit Novik
  • S Kumar
  • Griet Vanpoucke
  • Juha Kere
  • Ahmet Mentese
  • Ruey Bing Yang
  • Cheng Fen Tu
  • Suha Turkmen
  • Wei Ju Liao
  • Mustafa Karabacak
  • Yuh Charn Lin
  • Ku Chi Tsao
  • Suleyman Caner Karahan
  • Ya Suo Ding
  • Helmut Fuchs
  • Dao Fu Dai
  • Cihangir Erem
  • Shen Zhong Qiu
  • Kenan Ahmet Turkdogan
  • Yeşim Bayoğlu Tekin
  • Abdulkadir Gunduz
  • Ertan Sönmez
  • Turkan Ozturk Topcu
  • Steve R Roffler
  • Meng Ying Wu
  • Ming Tzu Tsai
  • Diler Us Altay
  • Halil Kavgaci
  • Gulsum Ozkan
  • Guilherme M Xavier
  • Min Yang
  • Hirowati Ali
  • Brigid Orr
  • Tiina M Järvinen
  • Jacque Lynne F A Johnson
  • Elina Levina
  • Yu Ting Yan
  • Martyn T Cobourne
  • S Grimmond
  • Junli Zhuang
  • Guilheme M Xavier
  • W Franklin Peacock
  • Chien Jui Cheng
  • Stephan Lindemann
  • Yueh Hsing Su
  • Hanqing Xie
  • Bo Tsung Wu
  • Koichiro Abe
  • Juan Antonio Aguilar-Pimentel
  • Martin Klingenspor
  • Qin Zhang
  • Dirk H Busch
  • Bing Sun
  • Thomas Klopstock
  • Guang Zhong Gao
  • Michael Sandholzer
  • Dian Michel
  • Claudia Stoeger
  • Markus Ollert
  • Nadim Civan
  • Bettina Lorenz-Depiereux
  • Tim M Strom
  • Zeynep Akgul
  • Hong Xiang Wang
  • Johannes Beckers
  • Christine Gau
  • Ralf Elvert
  • Holger Maier
  • Gerhard K H Przemeck
  • Jia Shen
  • Bin Chen
  • Jochen Graw
  • Tobias Stoeger
  • Wolfgang Wurst
  • Cornelia Prehn
  • John Favor
  • Hulya Coskun
  • Sibylle Sabrautzki
  • Orhan Deger
  • Kristin Moreth
  • Martin Hrabe de Angelis
  • Thomas Wieland
  • Ingrid L Vargas-Panesso

Detail Information

Publications45

  1. ncbi Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, United Kingdom
    Genomics 70:74-81. 2000
    ..The Scube1 (signal peptide-CUB domain-EGF-related 1) gene was isolated from a developing mouse urogenital ridge cDNA library ..
  2. doi Disruption of Scube2 Impairs Endochondral Bone Formation
    Yuh Charn Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Bone Miner Res 30:1255-67. 2015
    ..In this study, we first showed that as compared with SCUBE1 or SCUBE3, SCUBE2 is the most potent modulator of IHH signaling in vitro...
  3. doi Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH)
    Jan Kuhnisch
    Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig Maximilians University of Munich, Goethestraße70, Munich, 80336, Germany
    Clin Oral Investig 18:677-82. 2014
    ..Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed...
  4. ncbi Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis
    Hirowati Ali
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 59:E122-31. 2013
    ..Two members of the SCUBE family, SCUBE1 and SCUBE3 are reported to play a role in cardiovascular diseases...
  5. doi Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis
    Meng Ying Wu
    From the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan M Y W, Y C L, W J L, R B Y Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan M Y W, Y C L, W J L, C F T, S R R, R B Y Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan C F T Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan C F T Department of Applied Statistics and Information Science, Ming Chuan University, Taoyuan, Taiwan M H C and Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan R B Y
    Arterioscler Thromb Vasc Biol 34:1390-8. 2014
    Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), a secreted and surface-exposed glycoprotein on activated platelets, promotes platelet-platelet interaction and supports platelet-matrix adhesion...
  6. doi The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome
    Ertan Sönmez
    Bezmialem Vakif University, Department of Emergency Medicine, Istanbul, Turkey Electronic address
    Am J Emerg Med 33:21-4. 2015
    ..Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of inactive platelets and secreted at a high rate during thrombosis...
  7. doi Is signal peptide-CUB-EGF domain-containing protein1 a diagnostic biomarker in patients with hypertensive crises
    Mustafa Karabacak
    Department of Cardiology, Isparta State Hospital, Isparta, Turkey
    Clin Hemorheol Microcirc 61:513-22. 2015
    ..Signal peptide-CUB-EGF domain-containing protein1 (SCUBE1), an indicator of platelet activation, is increased in HT...
  8. doi Diagnostic value of plasma signal peptide-Cub-Egf domain-containing protein-1 (SCUBE-1) in an experimental model of acute ischemic stroke
    Suha Turkmen
    Karadeniz Technical University, Faculty of Medicine, Department of Emergency Medicine, Trabzon, Turkey
    Am J Emerg Med 33:262-5. 2015
    This study was intended to examine possible diagnostic value of plasma Signal Peptide-Cub-Egf domain-containing protein-1 (SCUBE1) levels in an experimental model of acute ischemic stroke.
  9. doi The role of hypoxia at primary dysmenorrhea, utilizing a novel hypoxia marker--SCUBE1
    Yeşim Bayoğlu Tekin
    Department of Gynecology and Obstetrics, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey Electronic address
    J Pediatr Adolesc Gynecol 28:63-5. 2015
    To determine the SCUBE1 levels in adolescents with primary dysmenorrhea.
  10. doi The Diagnostic Value of Plasma SCUBE1, a Novel Biomarker of Platelet Activation, in Testicular Torsion: A Randomized, Controlled, Experimental Study
    Suleyman Turedi
    Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey Electronic address
    Urology 86:516-20. 2015
    To investigate the potential diagnostic value of plasma signal peptide, CUB (complement proteins C1r/C1s, Uegf, Bmp1) domain, epidermal growth factor (EGF)-like 1 (SCUBE1) protein in experimentally induced testicular torsion (TT).
  11. doi The value of signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) in the diagnosis of pulmonary embolism: a preliminary study
    Suha Turkmen
    Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
    Acad Emerg Med 22:922-6. 2015
    ..Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1 (SCUBE1) is a novel, secreted cell surface protein expressed during early embryogenesis...
  12. doi Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) levels in patients with overt and subclinical hyperthyroidism: effects of treatment
    Cihangir Erem
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Trabzon, Turkey
    Clin Endocrinol (Oxf) 84:919-24. 2016
    Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) has been shown to increase in parallel with platelet activation in acute ischaemic and thrombotic diseases...
  13. doi Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer
    Turkan Ozturk Topcu
    Division of Medical Oncology, Karadeniz Technical University School of Medicine
    Tohoku J Exp Med 237:127-32. 2015
    ..Signal Peptide-Cub-Epidermal growth factor domain-containing protein-1 (SCUBE1) is secreted under hypoxia and inflammatory conditions from platelet alpha granules...
  14. doi Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling
    Wei Ju Liao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Biochem J 473:661-72. 2016
    b>SCUBE1 (S1), a secreted and membrane-bound glycoprotein, has a modular protein structure composed of an N-terminal signal peptide sequence followed by nine epidermal growth factor (EGF)-like repeats, a spacer region and three cysteine-..
  15. doi Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury
    Qi Han Chen
    Department of Neurosurgery, The First People s Hospital of Tonglu County, 338 Xuesheng Road, Tonglu 311500, China Electronic address
    Clin Chim Acta 456:63-6. 2016
    Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is secreted under hypoxia and inflammatory conditions from platelet α granules...
  16. doi Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage
    Ya Suo Ding
    Department of Neurosurgery, Taizhou People s Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China Electronic address
    Clin Chim Acta 459:117-22. 2016
    Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is correlated with prognosis of some critical illnesses...
  17. doi The prognostic value of serum signal peptide-Cub-Egf domain-containing protein-1 concentrations in acute intracerebral hemorrhage
    Shen Zhong Qiu
    Department of Neurosurgery, The First People s Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China
    Clin Chim Acta 461:103-9. 2016
    Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1) in peripheral blood, which is identified as a marker for coagulation, was reported to be an independent predictor of poor outcome in some illnesses...
  18. pmc The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
    Helmut Fuchs
    German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    G3 (Bethesda) 6:4035-4046. 2016
    ..Scube (Signal peptide, CUB, and EGF-like domain-containing protein) family consists of three independent members, Scube1-3, which encode secreted cell surface-associated membrane glycoproteins...
  19. pmc Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis
    Ku Chi Tsao
    Institute of Biomedical Sciences, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 288:5017-26. 2013
    b>scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-containing protein 1), the founding member of a novel secreted and cell surface SCUBE protein family, is expressed predominantly in various developing ..
  20. doi Scube regulates synovial angiogenesis-related signaling
    Min Yang
    Rheumatology Center, PLA General Hospital of Chengdu Military Area Command, Chengdu, Sichuan Province, PR China National TCM Rehab Center, PLA General Hospital of Chengdu Military Area Command, Chengdu, Sichuan Province, PR China Key Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, Southern Medical University, Guangzhou, Guangdong Province, PR China Electronic address
    Med Hypotheses 81:948-53. 2013
    ..system defined by hedgehog (Hh), transforming growth factor (TGF)β and bone morphogenetic protein 2 (BMP2), Scube1 and 2 antagonize BMP2 signaling, suppressing BMP2-induced phospho-Smad1/5/8 level in vivo...
  21. doi The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever
    Ahmet Mentese
    Medical Laboratory Program, Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey Electronic address
    Int J Infect Dis 17:e1042-5. 2013
    The new biochemical marker, signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early embryogenesis. The protein is found in platelet and endothelial cells...
  22. doi New marker of platelet activation, SCUBE1, is elevated in hypertensive patients
    Gulsum Ozkan
    Department of Nephrology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey
    Am J Hypertens 26:748-53. 2013
    ..Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) is a novel platelet activation marker...
  23. doi Is SCUBE 1 a new biomarker for gastric cancer?
    Ahmet Mentese
    Medical Laboratory Program, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey
    Cancer Biomark 11:191-5. 2012
    ..This study was intended to determine the diagnostic significance of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE 1) levels in gastric cancer...
  24. ncbi SCUBE1--a new scoop in vascular biology?
    Stephan Lindemann
    Cardiovasc Res 71:414-5. 2006
  25. ncbi Will SCUBE1 solve the ischemia marker deficit?
    W Franklin Peacock
    J Am Coll Cardiol 51:2181-3. 2008
  26. doi Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner
    Elina Levina
    South Carolina College of Pharmacy, Department of Biomedical and Pharmaceutical Sciences, Columbia, South Carolina, USA
    Prostate 72:817-24. 2012
    ..that hedgehog agonist treatment induced in these cells expressions of hedgehog target genes (Gli1, Ptch1, and SCUBE1) plus a specific cadre of genes involved in cholesterol/steroid biosynthesis, metabolism, and transport...
  27. doi Scube activity is necessary for Hedgehog signal transduction in vivo
    Jacque Lynne F A Johnson
    Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia
    Dev Biol 368:193-202. 2012
    ..1996; Wolff et al., 2003). Here we present the discovery of two additional scube genes in zebrafish, scube1 and scube3, and demonstrate their roles in facilitating HH signal transduction...
  28. pmc Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1
    Brigid Orr
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Dis Model Mech 6:530-6. 2013
    ..We set out to reduce the pro-tumorigenic activity of patient CAFs using the Dlk1 and SCUBE1 molecules that we had previously identified in prostate development...
  29. pmc Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network
    S Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 217G, Birmingham, AL 35294, USA Electronic address
    Nutr Metab Cardiovasc Dis 23:987-94. 2013
    ..This is the first genome-wide association study of fenofibrate effects on circulating adiponectin...
  30. doi Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level
    Sukru Ulusoy
    Department of Nephrology, Karadeniz Technical University, School of Medicine, Turkey
    Clin Biochem 45:1444-9. 2012
    Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family...
  31. pmc Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse
    Guilherme M Xavier
    Department of Craniofacial Development and Stem Cell Biology, King s College London Dental Institute, London, United Kingdom
    PLoS ONE 8:e55274. 2013
    The vertebrate Scube family consists of three independent members Scube1-3; which encode secreted cell surface-associated membrane glycoproteins that share a domain organization of at least five recognizable motifs and the ability to both ..
  32. doi Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1
    Cheng Fen Tu
    Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Sec 2, Taipei 115
    J Biol Chem 283:12478-88. 2008
    b>SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) is a novel, secreted, cell surface glycoprotein expressed during early embryogenesis and found in platelet and endothelial cells...
  33. ncbi Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development
    S Grimmond
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK
    Mech Dev 102:209-11. 2001
    We have recently reported the preliminary characterisation of a novel EGF-related gene, Scube1 (signal peptide-CUB domain-EGF-related, gene 1), that is expressed prominently in the developing gonad, nervous system, somites, surface ..
  34. ncbi Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
    S Kumar
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Rd, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 9:641-53. 2001
    ..To prepare, sequence and analyse adult human cartilage cDNA libraries to study the gene expression pattern between normal and osteoarthritic cartilage...
  35. ncbi Identification of a novel family of cell-surface proteins expressed in human vascular endothelium
    Ruey Bing Yang
    Department of Cardiovascular Research, Millennium Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:46364-73. 2002
    ..harboring 10 epidermal growth factor (EGF)-like domains and one CUB domain at the carboxyl terminus (termed, SCUBE1 for Signal peptide-CUB-EGF-like domain containing protein 1) was identified...
  36. ncbi Bridging expressed sequence alignments through targeted cDNA sequencing
    Hanqing Xie
    Compugen, Inc, 7 Center Drive, Suite 9, Jamesburg, NJ 08831, USA
    Genomics 83:572-6. 2004
    ..Additional information about the contig pairs, the resultant overlapping sequences, tissue sources, and tissue profiles are available in a supplemental file...
  37. ncbi A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones
    Bo Tsung Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    J Biol Chem 279:37485-90. 2004
    ..Together, this novel secreted, cell-surface osteoblast protein may act locally and/or distantly through a proteolytic mechanism, and may play an important role in bone cell biology...
  38. ncbi Localization and characterization of a novel secreted protein SCUBE1 in human platelets
    Cheng Fen Tu
    Institute of Biomedical Sciences, Academia Sinica, and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cardiovasc Res 71:486-95. 2006
    ..was to investigate the protein expression and function of a novel secreted protein in the vascular system, named SCUBE1 for signal peptide, CUB (Complement proteins C1r/C1s, Uegf, and Bmp1) and epidermal growth factor-like (EGF)-like ..
  39. pmc Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease
    Griet Vanpoucke
    MRC Human Reproductive Sciences Unit, The Queens Medical Research Institute, Little France Crescent, Edinburgh EH16 4TJ, UK
    Genome Biol 8:R213. 2007
    ..We used serial analysis of gene expression (SAGE) to profile a key subset of prostatic mesenchyme that regulates prostate development and is enriched for growth-regulatory molecules...
  40. doi Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke
    Dao Fu Dai
    Section of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    J Am Coll Cardiol 51:2173-80. 2008
    This study investigates the potential application of plasma SCUBE1 [signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 1] as a biomarker of platelet activation in acute ..
  41. doi Scube1 is expressed during facial development in the mouse
    Guilheme M Xavier
    Department of Craniofacial Development, King s College London Dental Institute, London, United Kingdom
    J Exp Zool B Mol Dev Evol 312:518-24. 2009
    b>Scube1 encodes a secreted plasma membrane-associated protein characterized by a N-terminal signal peptide sequence, multiple EGF domains, a N-linked glycosylated spacer region and a C-terminal CUB region...
  42. doi SCUBE1, a novel developmental gene involved in renal regeneration and repair
    Junli Zhuang
    Monash Immunology and Stem Cell Laboratories, Monash University and the Australian Stem Cell Centre, Clayton, Victoria, Australia
    Nephrol Dial Transplant 25:1421-8. 2010
    We have identified that a novel developmental gene and protein, SCUBE1, is expressed in endothelial cells and may play an important role in kidney regeneration.
  43. pmc Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism
    J A Heit
    Division of Cardiovascular Diseases, Department of Internal Medicine Division of Experimental Pathology, Department of Laboratory Medicine and Pathology Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Thromb Haemost 9:1133-42. 2011
    ..Venous thromboembolism (VTE) is highly heritable (estimated heritability [h(2)]=0.62) and likely to be a result of multigenic action...
  44. doi Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population
    Tiina M Järvinen
    Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7 9, S 14183 Huddinge, Sweden
    Rheumatology (Oxford) 51:87-92. 2012
    ..In this study, we sought to replicate some of these results in Finnish SLE patients (n = 275) and control individuals (n = 356)...

Research Grants2

  1. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..