SARS2

Summary

Gene Symbol: SARS2
Description: seryl-tRNA synthetase 2, mitochondrial
Alias: SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, serine--tRNA ligase, mitochondrial, mitochondrial seryl-tRNA synthetase, serine tRNA ligase 2, mitochondrial, seryl-tRNA synthetase, mitochondrial, seryl-tRNA(Ser/Sec) synthetase
Species: human

Top Publications

  1. ncbi Scaffold attachment regions in centromere-associated DNA
    P L Strissel
    Department of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA
    Chromosoma 105:122-33. 1996
  2. ncbi Is thermal scanner losing its bite in mass screening of fever due to SARS?
    Eddie Y K Ng
    School of Mechanical and Production Engineering, College of Engineering, Nanyang Technical University, Singapore 639798, Singapore
    Med Phys 32:93-7. 2005
  3. pmc Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 42:2884-9. 2004
  4. ncbi Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
  5. doi A revisit on older adults suicides and Severe Acute Respiratory Syndrome (SARS) epidemic in Hong Kong
    Y T Cheung
    Centre for Suicide Research and Prevention, The University of Hong Kong, Hong Kong
    Int J Geriatr Psychiatry 23:1231-8. 2008
  6. ncbi Molecular biological analysis of genotyping and phylogeny of severe acute respiratory syndrome associated coronavirus
    Zhi Gang Wang
    Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China
    Chin Med J (Engl) 117:42-8. 2004
  7. ncbi Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection
    Claudia Diemer
    Institute of Virology, Technical University of Munich, Trogerstr 30, 81675 Munich, Germany
    J Mol Biol 376:23-34. 2008
  8. ncbi [A follow up study of total IgM, IgG, nucleoprotein and spike protein antibodies against severe acute respiratory syndrome (SARS) coronavirus in patients with SARS]
    Hui ping YAN
    Central Laboratory of Infectious Diseases, Beijing Youan Hospital, Capital University of Medical Sciences, Beijing 100069, China
    Zhonghua Nei Ke Za Zhi 45:896-9. 2006
  9. ncbi Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS
    Alexander Bukreyev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet 363:2122-7. 2004
  10. ncbi Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine
    Ede Qin
    Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing, PR China
    Vaccine 24:1028-34. 2006

Research Grants

  1. Analysis of the SARS Virus S glycoproteins
    Paul Bates; Fiscal Year: 2005
  2. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
  3. Stanley Perlman; Fiscal Year: 2015
  4. Inhibition of the Innate Immune Response by the SARS Coronavirus
    MATTHEW BRYAN FRIEMAN; Fiscal Year: 2010
  5. Priming and fusion activation of the SARS coronavirus spike glycoprotein
    Gary R Whittaker; Fiscal Year: 2010
  6. Fang Li; Fiscal Year: 2016
  7. SARS Coronavirus Virulence Factors and Lung Pathogenesis
    Marc G Wathelet; Fiscal Year: 2010
  8. VICTORIA MANUEL D'SOUZA; Fiscal Year: 2016
  9. EFFECTORS AND IINHIBITORS OF SARS VIRUS POLYMERASE
    Neerja Kaushik Basu; Fiscal Year: 2006
  10. Development of a SARS Coronavirus Vaccine
    Jeffrey Ulmer; Fiscal Year: 2004

Detail Information

Publications260 found, 100 shown here

  1. ncbi Scaffold attachment regions in centromere-associated DNA
    P L Strissel
    Department of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA
    Chromosoma 105:122-33. 1996
    ..1984), we chose to map the distribution of scaffold attachment regions (SARs) at centromeres. Using the SAR mapping assay of Mirkovitch et al...
  2. ncbi Is thermal scanner losing its bite in mass screening of fever due to SARS?
    Eddie Y K Ng
    School of Mechanical and Production Engineering, College of Engineering, Nanyang Technical University, Singapore 639798, Singapore
    Med Phys 32:93-7. 2005
    Severe acute respiratory syndrome (SARS) is a highly infectious disease caused by a coronavirus. Screening to detect a potential SARS infected person plays an important role in preventing the spread of SARS...
  3. pmc Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 42:2884-9. 2004
    ..development of an enzyme-linked immunosorbent assay (ELISA) for the detection of severe acute respiratory syndrome (SARS) coronavirus (CoV) nucleocapsid protein...
  4. ncbi Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
    Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase ..
  5. doi A revisit on older adults suicides and Severe Acute Respiratory Syndrome (SARS) epidemic in Hong Kong
    Y T Cheung
    Centre for Suicide Research and Prevention, The University of Hong Kong, Hong Kong
    Int J Geriatr Psychiatry 23:1231-8. 2008
    The Severe Acute Respiratory Syndrome (SARS) outbreak in 2003 had an enormous impact on Hong Kong society and the suicide rate was also at its historical high, 18.6 per 100,000...
  6. ncbi Molecular biological analysis of genotyping and phylogeny of severe acute respiratory syndrome associated coronavirus
    Zhi Gang Wang
    Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China
    Chin Med J (Engl) 117:42-8. 2004
    b>SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS) which has been associated with outbreaks of SARS in Guangdong, Hong Kong and Beijing of China, and other regions worldwide...
  7. ncbi Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection
    Claudia Diemer
    Institute of Virology, Technical University of Munich, Trogerstr 30, 81675 Munich, Germany
    J Mol Biol 376:23-34. 2008
    The epidemic outbreak of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus (CoV), designated SARS-CoV. The RNA genome of SARS-CoV is complexed by the nucleocapsid protein (N) to form a helical nucleocapsid...
  8. ncbi [A follow up study of total IgM, IgG, nucleoprotein and spike protein antibodies against severe acute respiratory syndrome (SARS) coronavirus in patients with SARS]
    Hui ping YAN
    Central Laboratory of Infectious Diseases, Beijing Youan Hospital, Capital University of Medical Sciences, Beijing 100069, China
    Zhonghua Nei Ke Za Zhi 45:896-9. 2006
    To survey the dynamic changing and persistence of the special antibodies, including total IgM, IgG, nucleocapsid protein and spike protein antibodies, against severe acute respiratory syndrome coronavirus (SARS-CoV) in patients with SARS.
  9. ncbi Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS
    Alexander Bukreyev
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet 363:2122-7. 2004
    The outbreak of severe acute respiratory syndrome (SARS) in 2002 was caused by a previously unknown coronavirus-SARS coronavirus (SARS-CoV)...
  10. ncbi Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine
    Ede Qin
    Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Fengtai District, Beijing, PR China
    Vaccine 24:1028-34. 2006
    In 2003, severe acute respiratory syndrome (SARS) resulted in hundreds of infections and deaths globally. We aim to assess immunogenicity and protective efficacy of purified inactivated Vero-cell SARS vaccine in monkeys.
  11. pmc Association of HLA class I with severe acute respiratory syndrome coronavirus infection
    Marie Lin
    Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
    BMC Med Genet 4:9. 2003
    ..During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many health care workers were infected...
  12. ncbi Analysis of multimerization of the SARS coronavirus nucleocapsid protein
    Runtao He
    National Microbiology Laboratory, Health Canada, 1015 Arlington St, Winnipeg, MB, Canada R3E 3R2
    Biochem Biophys Res Commun 316:476-83. 2004
    Severe Acute Respiratory Syndrome (SARS), an emerging disease characterized by atypical pneumonia, has recently been attributed to a novel coronavirus...
  13. ncbi Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion
    Chad M Petit
    Division of Biotechnology and Molecular Medicine BIOMMED, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Virology 341:215-30. 2005
    The SARS-coronavirus (SARS-CoV) is the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion...
  14. ncbi Influence of meteorological factors and air pollution on the outbreak of severe acute respiratory syndrome
    Quan Cai Cai
    Department of Epidemiology, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Public Health 121:258-65. 2007
    To understand the association between the outbreak of severe acute respiratory syndrome (SARS) and meteorological factors and air pollution.
  15. pmc Two-way antigenic cross-reactivity between severe acute respiratory syndrome coronavirus (SARS-CoV) and group 1 animal CoVs is mediated through an antigenic site in the N-terminal region of the SARS-CoV nucleoprotein
    Anastasia N Vlasova
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691 4096, USA
    J Virol 81:13365-77. 2007
    In 2002, severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged in humans, causing a global epidemic. By phylogenetic analysis, SARS-CoV is distinct from known CoVs and most closely related to group 2 CoVs...
  16. ncbi SARS outbreaks in Ontario, Hong Kong and Singapore: the role of diagnosis and isolation as a control mechanism
    G Chowell
    Center for Nonlinear Studies, MS B258, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Theor Biol 224:1-8. 2003
    In this article we use global and regional data from the SARS epidemic in conjunction with a model of susceptible, exposed, infective, diagnosed, and recovered classes of people ("SEIJR") to extract average properties and rate constants ..
  17. ncbi The nucleocapsid protein of the SARS coronavirus is capable of self-association through a C-terminal 209 amino acid interaction domain
    Milan Surjit
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India
    Biochem Biophys Res Commun 317:1030-6. 2004
    Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) caused a severe outbreak in several regions of the world in 2003...
  18. ncbi SR-rich motif plays a pivotal role in recombinant SARS coronavirus nucleocapsid protein multimerization
    Haibin Luo
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
    Biochemistry 44:15351-8. 2005
    The nucleocapsid (N) protein of SARS coronavirus (SARS-CoV) is reported to function in encapsidating the viral genomic RNA into helical nucleocapsid, and its self-association is believed to be vital in coating the viral genomic RNA...
  19. pmc A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice
    Anjeanette Roberts
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 3:e5. 2007
    No single animal model for severe acute respiratory syndrome (SARS) reproduces all aspects of the human disease...
  20. ncbi Impact of severe acute respiratory syndrome care on the general health status of healthcare workers in taiwan
    Ning Hung Chen
    Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Infect Control Hosp Epidemiol 28:75-9. 2007
    The impact of the outbreak of severe acute respiratory syndrome (SARS) was enormous, but few studies have focused on the infectious and general health status of healthcare workers (HCWs) who treated patients with SARS.
  21. ncbi Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV
    Fumihiko Yasui
    Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Japan
    J Immunol 181:6337-48. 2008
    The details of the mechanism by which severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe pneumonia are unclear...
  22. pmc The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors
    Milan Surjit
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India
    Biochem J 383:13-8. 2004
    ..atypical pneumonia, and was subsequently proven to be the causative agent of the disease now referred to as SARS (severe acute respiratory syndrome)...
  23. pmc The immediate effects of the severe acute respiratory syndrome (SARS) epidemic on childbirth in Taiwan
    Cheng Hua Lee
    Institute of Health Care and Hospital Administration, National Yang Ming University, 155 Li Nong Street, Section 2, Taipei, 112 Taiwan
    BMC Public Health 5:30. 2005
    When an emerging infectious disease like severe acute respiratory syndrome (SARS) strikes suddenly, many wonder the public's overwhelming fears of SARS may deterred patients from seeking routine care from hospitals and/or interrupt ..
  24. ncbi Laboratory containment of SARS virus
    Wilina Lim
    Virology Division, Public Health Labortory Services Branch, Centre for Health Protection, Department of Health, Hong Kong
    Ann Acad Med Singapore 35:354-60. 2006
    Following the severe acute respiratory syndrome (SARS) outbreak in 2003, a large number of clinical and environmental samples containing/potentially containing SARS coronavirus (SARSCoV) as well as SARS-CoV stocks were retained in ..
  25. pmc SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro
    Martijn J van Hemert
    Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 4:e1000054. 2008
    b>SARS-coronavirus (SARS-CoV) replication and transcription are mediated by a replication/transcription complex (RTC) of which virus-encoded, non-structural proteins (nsps) are the primary constituents...
  26. ncbi Epidemiological characteristics of an outbreak of severe acute respiratory syndrome in Dongcheng District of Beijing from March to May 2003
    Wan Nian Liang
    Department of Epidemiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China
    Biomed Environ Sci 16:305-13. 2003
    To describe epidemiologic features of an outbreak of severe acute respiratory syndrome (SARS) in Dongcheng District, Beijing occurred in a period between March and May 2003.
  27. doi Surface-enhanced Raman scattering: realization of localized surface plasmon resonance using unique substrates and methods
    Mohammad Kamal Hossain
    Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Gakuen 2 1, Sanda, Hyogo, 669 1337, Japan
    Anal Bioanal Chem 394:1747-60. 2009
    Surface-enhanced Raman scattering (SERS) enhancement and the reproducibility of the SERS signal strongly reflect the quality and nature of the SERS substrates because of diverse localized surface plasmon resonance (LSPR) excitations ..
  28. ncbi Transmission of the severe acute respiratory syndrome on aircraft
    Sonja J Olsen
    International Emerging Infections Program, Centers for Disease Control and Prevention, Nonthaburi, Thailand
    N Engl J Med 349:2416-22. 2003
    The severe acute respiratory syndrome (SARS) spread rapidly around the world, largely because persons infected with the SARS-associated coronavirus (SARS-CoV) traveled on aircraft to distant cities...
  29. pmc Date of origin of the SARS coronavirus strains
    Hongchao Lu
    Bioinformatics Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P R China
    BMC Infect Dis 4:3. 2004
    A new respiratory infectious epidemic, severe acute respiratory syndrome (SARS), broke out and spread throughout the world. By now the putative pathogen of SARS has been identified as a new coronavirus, a single positive-strand RNA virus...
  30. ncbi Loss of paramedic availability in an urban emergency medical services system during a severe acute respiratory syndrome outbreak
    P Richard Verbeek
    Division of Prehospital Care, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Acad Emerg Med 11:973-8. 2004
    To describe the loss of paramedic availability to Toronto Emergency Medical Services during a biphasic (SARS-1 and SARS-2) outbreak of severe acute respiratory syndrome (SARS).
  31. pmc SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
    Amy C Sims
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Virus Res 133:33-44. 2008
    b>SARS coronavirus (SARS-CoV) emerged in 2002 as an important cause of severe lower respiratory tract infection in humans and in vitro models of the lung are needed to elucidate cellular targets and the consequences of viral infection...
  32. doi Pathology of experimental SARS coronavirus infection in cats and ferrets
    J M A van den Brand
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vet Pathol 45:551-62. 2008
    The pathology of severe acute respiratory syndrome-coronavirus (SARS-CoV) infection in cats and ferrets is poorly described, and the distribution of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV, in the respiratory ..
  33. pmc Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
    C M Chu
    Department of Microbiology and Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Thorax 59:252-6. 2004
    The clinical response of patients with severe acute respiratory syndrome (SARS) to a combination of lopinavir/ritonavir and ribavirin was examined after establishing the in vitro antiviral susceptibility of the SARS associated coronavirus ..
  34. pmc Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design
    Yuxian He
    Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
    J Virol 80:5757-67. 2006
    The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates the receptor interaction and immune recognition and is considered a major target for vaccine design...
  35. ncbi SARS/avian coronaviruses
    C Monceyron Jonassen
    Section for Virology and Serology, National Veterinary Institute, Oslo, Norway
    Dev Biol (Basel) 126:161-9; discussion 326-7. 2006
    In the hunt for the aetiology of the SARS outbreak in 2003, a newly developed virus DNA micro-array was successfully used to hybridise PCR products obtained by random amplification of nucleic acids extracted from a cell culture infected ..
  36. ncbi An efficient RNA-cleaving DNA enzyme can specifically target the 5'-untranslated region of severe acute respiratory syndrome associated coronavirus (SARS-CoV)
    Shuwen Wu
    Modern Virology Research Center, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Gene Med 9:1080-6. 2007
    The worldwide epidemic of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus called SARS-CoV...
  37. pmc Anatomy of the epidemiological literature on the 2003 SARS outbreaks in Hong Kong and Toronto: a time-stratified review
    Weijia Xing
    INSERM, U707, Paris, France
    PLoS Med 7:e1000272. 2010
    ..Using the 2003 severe acute respiratory syndrome (SARS) epidemic as an example, we conducted a comprehensive time-stratified review of the published literature to ..
  38. ncbi Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
    Thijs Kuiken
    Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, Netherlands
    Lancet 362:263-70. 2003
    The worldwide outbreak of severe acute respiratory syndrome (SARS) is associated with a newly discovered coronavirus, SARS-associated coronavirus (SARS-CoV)...
  39. ncbi Severe acute respiratory syndrome: pertinent clinical characteristics and therapy
    Thomas M File
    Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Treat Respir Med 4:95-106. 2005
    Severe acute respiratory syndrome (SARS) is a newly emerged infection that is caused by a previously unrecognized virus - a novel coronavirus designated as SARS-associated coronavirus (SARS-CoV)...
  40. pmc Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis
    Chung Y Cheung
    Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam Road, Hong Kong, Special Administrative Region, People s Republic of China
    J Virol 79:7819-26. 2005
    The pathogenesis of severe acute respiratory syndrome (SARS) remains unclear...
  41. ncbi Patient satisfaction with doctor-patient interaction in a radiotherapy centre during the severe acute respiratory syndrome outbreak
    J I Tang
    Department of Radiation Oncology, The Cancer Institute, National University Hospital, Singapore 119074, Singapore
    Australas Radiol 49:304-11. 2005
    ..radiotherapy department assessed how precautions implemented during the severe acute respiratory syndrome (SARS) outbreak affected patient satisfaction with doctor-patient interaction and explored variables potentially ..
  42. pmc Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans
    Bryan T Phillips
    Department of Biochemistry and Zoology and Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 104:3231-6. 2007
    ..In Caenorhabditis elegans, SYS-1/beta-catenin and POP-1/TCF regulate several asymmetric divisions, including that of the somatic gonadal precursor ..
  43. pmc Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    Santhana G Devaraj
    Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    J Biol Chem 282:32208-21. 2007
    Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant mortality...
  44. pmc Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin
    Wuze Ren
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China
    J Virol 82:1899-907. 2008
    Severe acute respiratory syndrome (SARS) is caused by the SARS-associated coronavirus (SARS-CoV), which uses angiotensin-converting enzyme 2 (ACE2) as its receptor for cell entry...
  45. pmc The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes
    Jinzhi Tan
    Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lubeck, Lubeck, Germany
    PLoS Pathog 5:e1000428. 2009
    Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the three-dimensional structures of several of the replicase/transcriptase components of SARS coronavirus (SARS-CoV), the non-structural proteins (Nsps), have been ..
  46. ncbi The yeast Rad6 protein: a mediator of homologous recombination across the scaffold attached region at the replication origin ARS1
    M B Markvart
    Department of Molecular Biology, Odense University, Denmark
    Yeast 12:1427-38. 1996
    ..Our observations strongly support the notion of torsionally separated chromosomal domains being organized by SARs and scaffold proteins, and being dynamically realigned as a consequence of ubiquitination and proteolysis.
  47. ncbi The development of a Somatic Amplification Rating Scale for low-back pain
    G A Korbon
    Department of Anesthesiology, University of Virginia Medical Center, Charlottesville
    Spine (Phila Pa 1976) 12:787-91. 1987
    The development of a new scale, the Somatic Amplification Rating Scale (SARS), for the quantification of exaggerated (nonorganic) motor, sensory, and pain responses occurring during a standardized physical examination is described...
  48. ncbi Severe acute respiratory syndrome in children: experience in a regional hospital in Hong Kong
    Wa Keung Chiu
    Department of Pediatrics and Adolescent Medicine, United Christian Hospital, Kwun Tong, Hong Kong
    Pediatr Crit Care Med 4:279-83. 2003
    To report the clinical, laboratory, and radiologic features of children with severe acute respiratory syndrome (SARS) and to examine the difference between the younger and older age groups.
  49. ncbi Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome
    Thomas W K Lew
    Department of Anaesthesiology, Tan Tock Seng Hospital, Singapore
    JAMA 290:374-80. 2003
    Severe acute respiratory syndrome (SARS) is an emerging infectious disease with a 25% incidence of progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and mortality exceeding 10%.
  50. ncbi SARS--lessons from two Singapore General Hospital cases
    Y Y Ong
    Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore 169608
    Singapore Med J 44:420-2. 2003
    Two cases of Severe Acute Respiratory Syndrome (SARS) that occurred in Singapore General Hospital are described. The lessons learnt are outlined.
  51. ncbi [Central issues of prevention of nosocomial infections--status in 2004]
    Ch Ruef
    Abteilung Infektionskrankheiten und Spitalhygiene, Universitatsspital Zurich
    Ther Umsch 61:191-6. 2004
    ..Given the growing complexity and the emergence of new nosocomial threats such as SARS, hospital administrators are well advised to invest sufficiently into their department of hospital hygiene and ..
  52. pmc Regulatory elements of the Staphylococcus aureus protein A (Spa) promoter
    Jinxin Gao
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    J Bacteriol 186:3738-48. 2004
    ..spa expression has been found to be complicated, with regulation involving multiple factors, including Agr, SarA, SarS, SarT, Rot, and MgrA...
  53. pmc Viral evolution and the emergence of SARS coronavirus
    Edward C Holmes
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Philos Trans R Soc Lond B Biol Sci 359:1059-65. 2004
    The recent appearance of severe acute respiratory syndrome coronavirus (SARS-CoV) highlights the continual threat to human health posed by emerging viruses...
  54. ncbi The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome
    Yi Ren
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Proteomics 4:3477-84. 2004
    Severe acute respiratory syndrome (SARS) is a new infectious disease with a global impact...
  55. ncbi SARS coronavirus E protein forms cation-selective ion channels
    Lauren Wilson
    Medical School, Frank Fenner Building 42, ANU, Canberra, ACT 2601, Australia
    Virology 330:322-31. 2004
    Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein...
  56. ncbi [Comparison of serum biochemical features between SARS and other viral pneumonias]
    Shu Zhen Song
    Department of Clinical Biochemistry, PLA General Hospital and Postgraduate Medical School, Beijing 100853, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:664-6. 2004
    To identify blood chemistry changes in coronavirus of severe acute respiratory syndrome (SARS).
  57. ncbi Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?
    K W Tsang
    Dept of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Eur Respir J 24:1025-32. 2004
    In 2003, the onset of severe acute respiratory syndrome (SARS) caused worldwide chaos. Although SARS was eradicated by isolation towards the end of 2003, sporadic cases have been reported in Singapore, Taiwan and mainland China...
  58. ncbi Psychological distress and negative appraisals in survivors of severe acute respiratory syndrome (SARS)
    S K W Cheng
    Consultation and Liaison Psychiatry Team, Kwai Chung Hospital, Hong Kong
    Psychol Med 34:1187-95. 2004
    Severe acute respiratory syndrome (SARS) is a novel disease. The authors have limited knowledge of its impact on mental health...
  59. ncbi Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
    Jan Balzarini
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Antiviral Res 72:20-33. 2006
    ..have been evaluated for their inhibitory activity against feline infectious peritonitis virus (FIPV) and human (SARS-CoV, Frankfurt-1 strain) coronavirus in cell culture in comparison with their activity against human ..
  60. ncbi Congruent epidemic models for unstructured and structured populations: analytical reconstruction of a 2003 SARS outbreak
    John N Bombardt
    Institute for Defense Analyses, 4850 Mark Center Drive, Alexandria, VA 22311 1882, United States
    Math Biosci 203:171-203. 2006
    ..Numerical results are obtained for the 2003 SARS outbreak in Taiwan and the dynamical implications of time-varying transmission rates and scale-free contact ..
  61. ncbi Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong
    Virology 367:428-39. 2007
    Apart from bat-SARS-CoV, we have identified a novel group 1 coronavirus, bat-CoV HKU2, in Rhinolophus sinicus (Chinese horseshoe bats)...
  62. pmc Understanding, compliance and psychological impact of the SARS quarantine experience
    D L Reynolds
    Clinical Development, Sanofi Pasteur, Connaught Campus, Toronto, ON, Canada
    Epidemiol Infect 136:997-1007. 2008
    This study examines a cohort of persons quarantined during the 2003 SARS outbreak in Canada and describes their understanding of, difficulties and compliance with, and the psychological impact of the quarantine experience...
  63. pmc Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci
    Silvia Herbert
    Microbial Genetics Department, University of Tubingen, Tubingen, Germany
    PLoS Pathog 3:e102. 2007
    ..It up-regulates global regulators (rot, sarS, or mgrA), various colonization factors, and exotoxin-encoding genes, as well as the ica and dlt operons...
  64. pmc Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Virology 368:317-21. 2007
    Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins...
  65. doi Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
    Hsiu Chen Lin
    Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan School of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochem Pharmacol 75:1416-25. 2008
    ..of the derivatives on the inhibition of xanthine oxidase (XO) activity, and the structure-activity relationships (SARs) of these derivatives against XO activity were further examined using computer-aided molecular modeling...
  66. doi A single amino acid substitution in the S1 and S2 Spike protein domains determines the neutralization escape phenotype of SARS-CoV
    Yu Ya Mitsuki
    Department of Immunology, National Institute of Infectious Diseases, Toyama 1 23 1, Tokyo 162 8640, Japan
    Microbes Infect 10:908-15. 2008
    In response to SARS-CoV infection, neutralizing antibodies are generated against the Spike (S) protein...
  67. doi In situ surface-enhanced Raman scattering analysis of biofilm
    Natalia P Ivleva
    Institute of Hydrochemistry, Technische Universitat Munchen, Marchioninistrasse 17, D 81377, Munich, Germany
    Anal Chem 80:8538-44. 2008
    ..However, the sensitivity of RM is limited. Surface-enhanced Raman scattering (SERS), which enables investigations of biomolecules at very low concentration levels, allows overcoming this drawback...
  68. ncbi Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome
    Y L Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong SAR, China
    Hong Kong Med J 15:43-6. 2009
    1. The IFN-gamma +874A allele and RANTES -28 G allele are risk factors for SARS susceptibility. 2. The RANTES -28 G allele plays a role in the pathogenesis of SARS. 3...
  69. doi Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents
    Huan Qiu Li
    State Key Laboratory of Pollution Control and Resource Reuse, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China
    Bioorg Med Chem 18:305-13. 2010
    ..These compounds displayed good EGFR and HER-2 inhibitory activity and the SARs are also been studied. Especially compound 7b demonstrated significant EGFR and HER-2 inhibitory activity (IC(50)=0...
  70. doi Coupling surface-enhanced resonance Raman scattering and electronic tongue as characterization tools to investigate biological membrane mimetic systems
    Pedro H B Aoki
    Faculdade de Ciencias e Tecnologia, Unesp Univ Estadual Paulista, Presidente Prudente SP, 19060 900, Brazil
    Anal Chem 82:3537-46. 2010
    ..In this work, surface-enhanced resonance Raman scattering (SERRS) and an electronic tongue system using impedance spectroscopy were brought together, combining sensitivity and ..
  71. doi The bisnaphthalimides as new active lead compounds against Plasmodium falciparum
    Maximilian Tischer
    Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Bioorg Med Chem 18:2998-3003. 2010
    ..Since the SARs are different from reported biscationic antimalarial drugs the mode of action remains to be elucidated.
  72. doi Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy
    Adam J Lowe
    Graduate Field of Microbiology, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 82:5810-4. 2010
    ..We present the first multiplex LDR-surface enhanced Raman spectroscopy (SERS) SNP genotyping scheme...
  73. doi One-step functionalized gold nanorods as intracellular probe with improved SERS performance and reduced cytotoxicity
    Zhuyuan Wang
    Advanced Photonics Center, Southeast University, Nanjing 210096, Jiangsu, People s Republic of China
    Biosens Bioelectron 26:241-7. 2010
    An intracellular SERS probe based on gold nanorods (GNRs) is successfully presented with improved SERS performance and greatly reduced cytotoxicity...
  74. pmc Detection of Mycoplasma pneumoniae in simulated and true clinical throat swab specimens by nanorod array-surface-enhanced Raman spectroscopy
    Suzanne L Hennigan
    Department of Microbiology, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 5:e13633. 2010
    ..pneumoniae in culture and in spiked and true clinical throat swab samples by surface-enhanced Raman spectroscopy (SERS). Three M...
  75. doi [Health alert management and emerging risk]
    J Pillonel
    Institut de Veille Sanitaire, 12 Rue du Val d Osne, 94115 Saint Maurice cedex, France
    Transfus Clin Biol 17:291-5. 2010
    ..and more recently those generated by the heat wave in 2003 or by emerging infectious pathogens (SARS, West Nile, Chikungunya, H5N1, H1N1…), a real health vigilance system has been progressively developed in France...
  76. doi Gaps remain in China's ability to detect emerging infectious diseases despite advances since the onset of SARS and avian flu
    Zijian Feng
    Office of Disease Control and Emergency Response, Chinese Center for DiseaseControl and Prevention, Beijing
    Health Aff (Millwood) 30:127-35. 2011
    ..country, which has been the focus of global attention since outbreaks of severe acute respiratory syndrome (SARS) and avian influenza...
  77. ncbi [The past decade's infectious diseases]
    Kåre Mølbak
    Epidemiologisk afdeling, Statens Serum Institut, 2300 København S, Denmark
    Ugeskr Laeger 173:414-6. 2011
    The past decade saw emerging infections such as SARS, avian and pandemic influenza, food-borne infections and the bioterror threat...
  78. doi A nanoscale DNA-Au dendrimer as a signal amplifier for the universal design of functional DNA-based SERS biosensors
    Yun Hong Sun
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    Chem Commun (Camb) 47:3840-2. 2011
    ..dendrimer as a signal amplifier was proposed for the universal design of functional DNA-based ultra-sensitive SERS biosensors...
  79. ncbi [Self-assembly of two kinds of nanoparticles and their surface enhanced Raman spectroscopic study]
    Cai Feng Huang
    Department of Chemistry, Chemical Engineering and Materials Sciences, Soochow University, Suzhou 215123, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:3240-3. 2010
    ..The authors used pyridine (Py) as a probing molecule, and surface enhanced Raman spectroscopy (SERS) effect was investigated on pure Au and Au-Au@Pt mixed nanoparticle surfaces under the excitation line of 632.8 nm...
  80. ncbi Hybrid Au/CNT systems: a novel breakthrough for enhanced Raman sensing of nitrile-based organic solvents
    Silvia Orlanducci
    Dip Scienze e tecnologie chimiche, Universita degli Studi di Roma, Tor Vergata Via della Ricerca Scientifica 1, 00133 Roma, Italy
    J Nanosci Nanotechnol 11:4882-7. 2011
    ..nabotube (CNT) deposits decorated with gold nanoparticles, and the use of Surface Enhanced Raman Spectroscopy (SERS) related to the strong plasmon absorption of gold for the detection of cyanide groups...
  81. pmc Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease
    Stephanie Bertram
    Institute of Virology, Hannover Medical School, Hannover, Germany
    J Virol 85:13363-72. 2011
    The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) poses a constant threat to human health. The viral spike protein (SARS-S) mediates host cell entry and is a potential target for antiviral intervention...
  82. pmc Uncovering text mining: a survey of current work on web-based epidemic intelligence
    Nigel Collier
    National Institute of Informatics, Tokyo, Japan
    Glob Public Health 7:731-49. 2012
    Real world pandemics such as SARS 2002 as well as popular fiction like the movie Contagion graphically depict the health threat of a global pandemic and the key role of epidemic intelligence (EI)...
  83. doi Molecular structure, natural bond analysis, vibrational, and electronic spectra of aspartateguanidoacetatenickel(II), [Ni(Asp)(GAA)]·H₂O: DFT quantum mechanical calculations
    J M Ramos
    IQ UFF, Departamento de Quimica Inorganica, Morro de Valonguinho s n Centro, 24210 150 Niterói, RJ, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 97:1041-51. 2012
    ..Second derivative of the FT-infrared, FT-Raman and Surface Raman Enhanced Scattering (SERS) spectra, and band deconvolution analysis were also performed...
  84. doi A chemical route to increase hot spots on silver nanowires for surface-enhanced Raman spectroscopy application
    Madeline Shuhua Goh
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371
    Langmuir 28:14441-9. 2012
    The effective number of surface-enhanced Raman spectroscopy (SERS) active hot spots on plasmonic nanostructures is the most crucial factor in ensuring high sensitivity in SERS sensing platform...
  85. doi Surface-enhanced Raman spectroscopy of double-shell hollow nanoparticles: electromagnetic and chemical enhancements
    Mahmoud A Mahmoud
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    Langmuir 29:6253-61. 2013
    ..The surface-enhanced Raman spectra (SERS) of thiophenol adsorbed on the surface of AuNCs assembled into a Langmuir-Blodgett monolayer were 10-fold stronger ..
  86. doi Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS
    Pratik Devasthale
    Metabolic Diseases Chemistry, Metabolic Diseases Biology, Pharmaceutical Candidate Optimization, Protein Science and Structure, Computer Assisted Drug Design, Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543 5400, United States
    J Med Chem 56:7343-57. 2013
    Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, ..
  87. doi Specific behavior of the p-aminothiophenol--silver sol system in their Ultra-Violet-Visible (UV-Visible) and Surface Enhanced Raman (SERS) spectra
    Tamás Firkala
    Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri ut 59 67, 1025 Budapest, Hungary Electronic address
    J Colloid Interface Sci 410:59-66. 2013
    The UV-Visible and Surface Enhanced Raman Spectroscopy (SERS) behavior of silver sol (a typical SERS agent) were studied in the presence of different bifunctional thiols such as p-aminothiophenol, p-mercaptobenzoic acid, p-nitrothiophenol,..
  88. doi Label-free detection of native proteins by surface-enhanced Raman spectroscopy using iodide-modified nanoparticles
    Li Jia Xu
    State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, and Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
    Anal Chem 86:2238-45. 2014
    ..Surface-enhanced Raman spectroscopy (SERS) can provide the intrinsic fingerprint information of samples with ultrahigh sensitivity but suffers from the ..
  89. ncbi [A novel coronavirus, MERS-CoV]
    Tetsuya Mizutani
    Research and Education Center for Prevention of Global Infectious Diseases of Animal, Tokyo University of Agriculture and Technology
    Uirusu 63:1-6. 2013
    ..of important coronavirus caused severe diseases to human after the outbreak of severe acute respiratory syndrome (SARS) coronavirus...
  90. pmc Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors
    Robert L LaFemina
    Editor, Antimicrobial Agents and Chemotherapy, Schwenksville, Pennsylvania, USA
    Antimicrob Agents Chemother 58:4251-2. 2014
    ..A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV.
  91. pmc Coronavirus reverse genetic systems: infectious clones and replicons
    Fernando Almazán
    Department of Molecular and Cell Biology Centro Nacional de Biotecnología CNB CSIC, Campus Universidad Autonoma de Madrid, C Darwin 3, Cantoblanco, 28049 Madrid, Spain
    Virus Res 189:262-70. 2014
    ..In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV).
  92. doi An electrochemically switched smart surface for peptide immobilization and conformation control
    Jun Li
    State Key Laboratory of Applied Organic Chemistry SKLAOC, College of Chemistry and Chemical Engineering, School of Basic Medical Sciences Lanzhou University, 222 Tianshui South Road, Lanzhou, 730000 China
    J Am Chem Soc 136:11050-6. 2014
    ..procedure can be well-monitored by cyclic voltammetry (CV), electrochemical surface enhanced Raman microscopy (EC-SERS), and X-ray photoelectron spectroscopy (XPS)...
  93. doi A silver nanoparticle embedded hydrogel as a substrate for surface contamination analysis by surface-enhanced Raman scattering
    Zhengjun Gong
    Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu, 610031, China
    Analyst 139:5283-9. 2014
    A surface enhanced Raman scattering (SERS) substrate, capable of extracting small amounts of organic species from surfaces of different types of materials with variable roughness, has been fabricated...
  94. doi Surveillance for emerging respiratory viruses
    Jaffar A Al-Tawfiq
    Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia Indiana University School of Medicine, Indianapolis, Indiana, USA
    Lancet Infect Dis 14:992-1000. 2014
    ..2003, WHO issued a worldwide alert for an unknown emerging illness, later named severe acute respiratory syndrome (SARS)...
  95. doi Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors
    Xin Han
    School of Pharmaceutical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, China430071
    Org Biomol Chem 12:8308-17. 2014
    ..We hope the identification of these indole-based amino acids as efficient NNRTIs of RT could stimulate researchers to develop more diversified anti-HIV drugs. ..
  96. doi Nanoencapsulated and microencapsulated SERS platforms for biomedical analysis
    Inna Y Stetciura
    Saratov State University, Astrakhanskaya Street 83, Saratov 410012, Russia
    Curr Opin Pharmacol 18:149-58. 2014
    The problems of layer-by-layer-based surface enhancement Raman scattering (SERS)-sensor application for pharmaceutical analysis were discussed...
  97. doi Core-size-dependent catalytic properties of bimetallic Au/Ag core-shell nanoparticles
    Krishna Kanta Haldar
    Department of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India
    ACS Appl Mater Interfaces 6:21946-53. 2014
    ..of functional materials because of their potential applications in catalysis, surface enhanced Raman scattering (SERS) substrate and photonics etc...
  98. doi Use of artificial neural networks in the QSAR prediction of physicochemical properties and toxicities for REACH legislation
    John C Dearden
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK
    Methods Mol Biol 1260:65-88. 2015
    ..Most ANN QSARs reported to date comply with only two of the five OECD Guidelines for the Validation of (Q)SARs.
  99. doi Waveguide-coupled directional Raman radiation for surface analysis
    Chen Chen
    State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P R China
    Phys Chem Chem Phys 17:21278-87. 2015
    ..Raman spectroscopy due to the following unique features: (1) unlike the classic surface enhanced Raman scattering (SERS) substrates made of either gold or silver, both PW and RM can be prepared using a large variety of inexpensive ..
  100. pmc A real-time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticles
    Ellis Garai
    Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America Molecular Imaging Program at Stanford MIPS, Stanford University, Stanford, California, United States of America
    PLoS ONE 10:e0123185. 2015
    The detection of biomarker-targeting surface-enhanced Raman scattering (SERS) nanoparticles (NPs) in the human gastrointestinal tract has the potential to improve early cancer detection; however, a clinically relevant device with rapid ..
  101. doi Nanocap array of Au:Ag composite for surface-enhanced Raman scattering
    Yongjun Zhang
    Key Laboratory of Functional Materials Physics and Chemistry, Jilin Normal University, Ministry of Education, Siping 136000, PR China Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 152:461-7. 2016
    ..PS) colloidal sphere templates in a magnetron sputtering system for the surface-enhanced Raman scattering (SERS) substrate...

Research Grants74

  1. Analysis of the SARS Virus S glycoproteins
    Paul Bates; Fiscal Year: 2005
    Severe Acute Respiratory Syndrome (SARS) is a rapidly emerging infectious disease...
  2. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
    ..The recently emerged human coronavirus, SARS-CoV, causes severe pneumonia and death...
  3. Stanley Perlman; Fiscal Year: 2015
    ..This was strikingly illustrated in the 2002-2003 outbreak of the Severe Acute Respiratory Syndrome (SARS), in which >50% of patients who were over 60 year old died while no deaths occurred in those under 24 years...
  4. Inhibition of the Innate Immune Response by the SARS Coronavirus
    MATTHEW BRYAN FRIEMAN; Fiscal Year: 2010
    Severe acute respiratory syndrome (SARS) is a potentially fatal disease that appears to have originated in the Guandong Province of China in the fall of 2002. The disease is caused by a new human coronavirus (CoV), named the SARS-CoV...
  5. Priming and fusion activation of the SARS coronavirus spike glycoprotein
    Gary R Whittaker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome (SARS) is a recently emerged viral disease caused by a coronavirus (SARS-CoV)...
  6. Fang Li; Fiscal Year: 2016
    ..Curiously, ACE2 is also used by group-II SARS coronavirus (SARS-CoV), the agent for the fatal human severe acute respiratory syndrome (SARS)...
  7. SARS Coronavirus Virulence Factors and Lung Pathogenesis
    Marc G Wathelet; Fiscal Year: 2010
    ..objectives of the application are to determine the mechanisms by which the Severe Acute Respiratory Syndrome (SARS)-associated coronavirus (SCoV) causes acute lung injury and to identify new therapeutic strategies...
  8. VICTORIA MANUEL D'SOUZA; Fiscal Year: 2016
    ..CoV) are associated with severe diseases as demonstrated by the 2003 severe acute respiratory syndrome (SARS)-CoV epidemic...
  9. EFFECTORS AND IINHIBITORS OF SARS VIRUS POLYMERASE
    Neerja Kaushik Basu; Fiscal Year: 2006
    ..The multi-domain replicase gene 1 of the SARS coronavirus (SARS-CoV), the recently identified causative agent of Severe Acute Respiratory Syndrome (SARS) ..
  10. Development of a SARS Coronavirus Vaccine
    Jeffrey Ulmer; Fiscal Year: 2004
    Severe Acute Respiratory Syndrome (SARS) is an acute infectious pneumonia caused by a new airborne coronavirus (SARS-CoV), which, in an epidemic of only a few months during 2003, affected approximately 8000 people with over 800 deaths...
  11. Synthetic Peptide SARS Coronavirus Diagnostic Kit
    Chang Wang; Fiscal Year: 2005
    The long-term objectives are to develop an enzyme-linked immunoassay (ELISA) for Severe Acute Respiratory Syndrome (SARS), based on synthetic peptide antigens...
  12. SARS Coronavirus Reverse Genetics and Pathogenesis
    PAUL MASTERS; Fiscal Year: 2005
    ..develop and apply this system to the coronavirus that is the causative agent for Severe Acute Respiratory Syndrome (SARS-CoV)...
  13. Development of Proteosome-adjuvanted nasal SARS vaccines
    David Burt; Fiscal Year: 2004
    Severe acute respiratory syndrome (SARS), now known to be caused by the SARS coronavirus (SARS-CoV), emerged in China in 2002 and was responsible for more then 8,000 cases of respiratory disease and 774 deaths world-wide...
  14. Structure of SARS Coronavirus Spike Glycoprotein
    Michael Root; Fiscal Year: 2005
    Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease with a mortality rate as high as 15%...
  15. Development of VLP Vaccines for SARS Prevention
    Richard Compans; Fiscal Year: 2005
    ..immunogens for eliciting strong neutralizing antibody responses against severe acute respiratory syndrome (SARS) coronavirus...
  16. Development of a plant-derived virus-like particle vaccine against SARS-CoV
    BRENDA HOGUE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus...
  17. Rhabdovirus-based recombinant vaccines against SARS
    Bernhard Dietzschold; Fiscal Year: 2006
    Recently an outbreak of atypical pneumonia designated severe acute respiratory syndrome (SARS) caused by a coronavirus (SARS-CoV) emerged first in humans in China and then spread to different countries...
  18. 2-5A Antisense for Degradation of SARS Coronavirus RNA
    Hagen Cramer; Fiscal Year: 2004
    Severe acute respiratory syndrome (SARS) is a newly recognized illness that has rapidly spread throughout Asia, North America and Europe...
  19. Therapeutic and Diagnostic Antibodies Against SARS
    EILEEN TOZER; Fiscal Year: 2006
    ..reagents that specifically recognize and neutralize the causative agent of severe acute respiratory syndrome, the SARS coronavirus (SARS-CoV)...
  20. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a zoonotic pathogen that likely emerged from bats, was amplified in civet cats and raccoon dogs and then transmitted to humans causing ..
  21. Andrew D Mesecar; Fiscal Year: 2016
    ..disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) outbreaks in humans...
  22. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..The emergence of a novel HCoV as the etiologic agent of severe acute respiratory syndrome (SARS) demonstrated the potential of coronaviruses to induce severe respiratory disease and cause a significant impact ..
  23. PAUL SCOTT MASTERS; Fiscal Year: 2015
    ..respiratory tract infections;a fifth human coronavirus is the causative agent of severe acute respiratory syndrome (SARS), which has the potential to re-emerge into the population from animal reservoirs...
  24. Modeling viral entry and its inhibition using SARS-CoV
    Graham Simmons; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) is a category C priority pathogen with a high fatality rate that retains the potential to cause a pandemic...
  25. Viral Protein Determinants of Coronavirus Replication Fidelity
    Everett Clinton Smith; Fiscal Year: 2013
    ..cause respiratory disease in humans ranging in severity from the common cold to severe acute respiratory syndrome (SARS)...
  26. XIIth International Nidovirus Symposium Support Proposal
    Udeni Balasuriya; Fiscal Year: 2011
    ..recent discovery of a previously unknown coronavirus that is now associated with Severe Acute Respiratory Syndrome (SARS), a newly emerged infectious disease in humans, underpins the importance of scientific research in this field...
  27. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): A Severe Acute Respiratory Syndrome (SARS) pandemic, caused by re-emergence of the causative coronavirus (CoV) from an animal reservoir, is a serious threat...
  28. Stanley Perlman; Fiscal Year: 2015
    Project Summary: The Severe Acute Respiratory Syndrome, caused by a novel coronavlrus (SARS-CoV), resulted in substantial morbidity and mortality in 2002-2003...
  29. Graham Simmons; Fiscal Year: 2014
    ..Filoviruses, the severe acute respiratory syndrome- coronavirus (Sars-CoV) and the Henipavirus genus of paramyxoviruses are all examples of such agents...
  30. A Genetic Analysis of Pneumotropism and Pneumovirulence in an MHV-1 Model of Sars
    Julian L Leibowitz; Fiscal Year: 2010
    The goal of this proposal is to delineate the viral genes that lead to severe acute respiratory syndrome (SARS) utilizing a novel rodent model of SARS. SARS infected over 8,000 persons globally with over 700 deaths...
  31. SARS-CoV Transcription Network Remodeling and the Attenuation of Pathogenesis
    RACHEL LAUREN GRAHAM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe acute respiratory syndrome (SARS) is a lower respiratory disease with approximately 10% mortality that emerged in the Guandong province of China in 2002...
  32. Shibo Jiang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The 2002-2003 pandemic of severe acute respiratory syndrome (SARS) posed an enormous threat to global public health and the social and economic stability...
  33. Epidemiology and Pathogenesis of Novel Coronaviruses
    SAMUEL RICHARD DOMINGUEZ; Fiscal Year: 2012
    Severe acute respiratory syndrome (SARS), caused by a new human coronavirus (SARS-CoV), represents the 21st century's first pandemic caused by a previously unknown etiological agent...
  34. A novel strategy for developing a SARS-CoV vaccine
    Stanley Perlman; Fiscal Year: 2009
    PROJECT SUMMARY/ABSTRACT Project Summary: The Severe Acute Respiratory Syndrome, caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity and mortality in 2002-2003...
  35. Characterization of the SARSCoV frameshift signal
    Jonathan D Dinman; Fiscal Year: 2010
    ..been shown to be utilized by the Coronaviruses (CoV), and primary sequence analysis of the rapidly emerging SARS-CoV, the etiological agent of Severe Acute Respiratory Syndrome (SARS), reveals the presence of a putative PRF ..
  36. A SARS-CoV Spike Protein Vaccine
    B Sim; Fiscal Year: 2005
    Severe acute respiratory syndrome (SARS) has been reported in Asia, North America, and Europe. In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of SARS...
  37. Macaque Model and Gene Expression Profiling of SARS
    Michael Katze; Fiscal Year: 2009
    In the winter of 2002-2003 a new viral pathogen, severe acute respiratory syndrome coronavirus (SARS-CoV), rapidly spread across 5 continents, infected over 8,000 people, and caused 774 deaths...
  38. Inflammatory Response and SARS Pathogenesis: An in vitro Model
    CHIEN TE TSENG; Fiscal Year: 2009
    Severe acute respiratory syndrome (SARS), caused by a novel coronavirus known as SARS-CoV, is a highly contagious and life-threatening respiratory disease, with the lungs as its main pathological target...
  39. Developing a recombinanat vacine for SARS
    Xuming Zhang; Fiscal Year: 2005
    The current epidemic of the severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, SARS-CoV. To date, the global confirmed SARS cases have reached >8,000 with L800 deaths in 30 countries...
  40. CELLULAR AND MOLECULAR MICROBIOLOGY TRAINING PROGRAM
    JACK J HAWIGER; Fiscal Year: 2010
    ..relevant to biodefense and other microbes that cause human diseases, including Severe Acute Respiratory Syndrome (SARS)...
  41. Kathleen A McDonough; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health ..
  42. Flow-enhanced characterization of drug-resistant viruses
    John Yin; Fiscal Year: 2010
    ..such as acquired immunodeficiency syndrome (AIDS), influenza, hepatitis, cancer, severe acute respiratory syndrome (SARS), hemorrhagic fever and the common cold...
  43. Development of Alphavirus Replicon Vaccine Against SARS
    Jonathan Smith; Fiscal Year: 2004
    ..of the proposed research is to develop a safe and effective vaccine for severe acute respiratory syndrome (SARS) using a single-cycle, alphavirus replicon vaccine vector that has been derived from an attenuated strain of ..
  44. Rapid NAT System for Point-of-care SARS Diagnosis
    Zihua Wang; Fiscal Year: 2004
    ..application is to develop a rapid, easy to use, integrated nucleic acid test for severe acute respiratory syndrome (SARS) based on our proprietary lab-in-a-tube (Liat TM) platform...
  45. STRUCTURAL STUDIES OF SARS AND MHV REPLICASE PROTEINS
    L Schultz; Fiscal Year: 2005
    Severe Acute Respiratory Syndrome (SARS) has recently emerged as a highly infectious and deadly disease and is caused by a virus that appears to have crossed the species barrier from wild animal to human...
  46. Development of peptide-based vaccine against SARS-CoV
    Gang Liu; Fiscal Year: 2009
    Severe acute respiratory syndrome (SARS) caused by coronavirus is an emerging human infectious disease that epidemically spread worldwide...
  47. Novel Protease Inhibitors as SARS Therapeutics
    Michael Johnson; Fiscal Year: 2009
    ..applicant): The development of new therapeutic drugs against the virus causing Severe Acute Respiratory Syndrome (SARS) is a clear imperative...
  48. SARS-CoV reverse genetics: expression of small ORFs
    Susan Weiss; Fiscal Year: 2006
    Within the last year a new coronavirus (SARS-CoV) has been identified as the etiological agent of severe acute respiratory syndrome (SARS)...
  49. Development of a vaccine against SARS-CoV
    Michael Cho; Fiscal Year: 2005
    Severe acute respiratory syndrome (SARS), caused by a novel coronavirus SARS-CoV, has been spreading rapidly across the globe...
  50. ASIM AMINSHARIF AHMED; Fiscal Year: 2015
    ..in this proposal are closely modeled after their approach towards the identification of the receptors for the SARS coronavirus and hemorrhagic New World arenaviruses and the chemokine co-receptors for HIV...
  51. NOX1 and NOX2 as Therapeutic Targets in Influenza
    JOHN DAVID LAMBETH; Fiscal Year: 2013
    ..Similar changes occur with other pathogens including SARS-Coronavirus and anthrax, where host-directed therapies developed for influenza are also expected to be effective...
  52. Coronavirus RNA Replication
    DAVID ALVIN BRIAN; Fiscal Year: 2012
    ..have arisen from the bovine enteric coronavirus, a close relative of the mouse hepatitis coronavirus, and the human SARS coronavirus is thought to have arisen from a bat enteric coronavirus...
  53. Bert L Semler; Fiscal Year: 2016
    ..a sheep retrovirus (JSRV), HIV, yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS coronavirus, arenaviruses, herpes simplex virus, Epstein-Barr virus, human papillomavirus, vaccinia virus, and a ..
  54. IMMUNITY AND VIRUS DISEASE
    Raymond M Welsh; Fiscal Year: 2013
    ..by agents such as HIV, HTLV, hepatitis viruses, ebola virus, hantavirus, papillomavirus, herpesviruses 6-8, the SARS coronavirus, and monkeypox, and we continue to live with the specter of the re-emergence of a 1918-1ike strain of ..
  55. Immune Regulation of Virus Clearance and Tissue Injury at Sites of Infection
    Thomas J Braciale; Fiscal Year: 2013
    ..recent examples of this are the immune-mediated lung inflammation/injury observed in human infections with the SARS coronavirus and the H5N1 avian influenza viruses...
  56. The Mechanisms of IFITM-Mediated Restriction
    I Chueh Huang; Fiscal Year: 2013
    ..My Ph.D. dissertation focused the enzymatic regulation of the entry processes of influenza A virus (IAV) and SARS coronavirus. These studies allowed me to develop an RNAi screen with Dr...
  57. Michel G Bergeron; Fiscal Year: 2014
    ..Seventeen viruses, including influenza A (such as avian flu and swine flu), influenza B, SARS coronavirus, parainfluenza, and adenovirus responsible for the majority of VRTI along with key antiviral resistance ..
  58. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2013
    ..The recently emerged SARS coronavirus is the first example of a severe disease in humans caused by a coronavirus...
  59. STRUCTURE AND ASSEMBLY OF VIRUSES
    STEPHEN COPLAN HARRISON; Fiscal Year: 2012
    ..We have also analyzed the conformational states of the SARS coronavirus spike protein and determined the structure of its receptor- binding domain bound with a soluble form of ..
  60. SARS Coronavirus: Inhibition of Entry
    Kathryn Holmes; Fiscal Year: 2009
    The Sudden Acute Respiratory Syndrome (SARS) epidemic has spread to 30 countries and killed more than 800 people in the 7-month period from November 2002, to June 2003...
  61. Targeting matrix metalloproteinases to limit immunopathology in airborne infectio
    SUWAN JAYASINGHE; Fiscal Year: 2013
    ..g., SARS coronavirus)...
  62. MATTHEW BRYAN FRIEMAN; Fiscal Year: 2016
    ..Highly pathogenic respiratory viruses, like the influenza virus and Severe Acute Respiratory Coronavirus (SARS-CoV), represent significant threats to the overall public health and to global economic stability...
  63. Antigenic Relationships of SARS and Animal Coronaviruses
    Linda Saif; Fiscal Year: 2006
    Severe acute respiratory syndrome (SARS) is a newly emerged global disease of significant economic impact and bioterrorism potential...
  64. Remodeling SARS Coronavirus Genome Regulatory Networks
    Ralph Baric; Fiscal Year: 2004
    ..virus (MHV), transmissible gastroenteritis virus (TGEV) and severe acute respiratory syndrome coronavirus (SARS-CoV)...
  65. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..The worldwide AIDS epidemic, the periodic emergence of Ebola and SARS, and the recent outbreaks of potentially pandemic strains of influenza such as H5N1 have highlighted a persistent ..
  66. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The worldwide AIDS epidemic, the periodic emergence of Ebola and SARS, and the recent outbreaks of potentially pandemic strains of influenza such as H5N1 have highlighted a persistent concern in the ..
  67. Identification of small molecule furin-like protease inhibitors
    JULIA COPPOLA; Fiscal Year: 2009
    ..of infectious viruses such as H5N1 avian influenza, HIV-1, human papillomavirus, ebola, yellow fever, and SARS-CoV...
  68. Porcine Respiratory Coronavirus as a SARS Model
    Linda Saif; Fiscal Year: 2007
    Severe acute respiratory syndrome (SARS) is a newly emerging global disease of humans with a major economic impact and significant bioterrorism potential caused by a new strain of coronavirus (CoV)...
  69. Dev. of a Suicide Prevention Training Curr f/Justice Sys Gatekeepers
    Henry J Steadman; Fiscal Year: 2009
    ..The potential for this project to have a significant impact on public health is paramount, as is its potential to act as a vehicle for creating, facilitating and integrating successful community partnerships . ..
  70. International Public Health Research Ethics Education and Curriculum Development
    Benfu Li; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): SARS and the threat of pandemic avian influenza have made it clear to the public and to the Government in China that public health must be a high priority...
  71. Primate Veterinarian Training at the WaNPRC
    Charlotte Hotchkiss; Fiscal Year: 2009
    ..for the use of NHPs in biomedical investigations, and emergence and spread of potentially deadly diseases such as SARS, influenza, and hepatitis that will be studied using NHP modes is expected to exacerbate the shortage of ..
  72. A Melamine Field Sensor for Surety Control of Dairy Products
    Kevin M Spencer; Fiscal Year: 2010
    ..The sensor is based on Surface-Enhanced Raman Spectroscopy (SERS), which allows precise detection of chemicals that adsorb strongly to roughened SERS sensors, like melamine, into ..
  73. Characterizing Class 1 Fusion Proteins: Elucidation of Coronavirus fusion peptide
    IKENNA MADU; Fiscal Year: 2009
    Since the incident of Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV), animal coronaviruses have been thrust into the limelight as important pathogens to study in relation to human disease...
  74. Nucleic Acid Dipstick for Rapid Avian Flu Detection at Point-of-care
    Hong Cai; Fiscal Year: 2009
    ..g. ~H5N1 avian flu, Type A human flu, RSV, SARS, adenoviruses, parainfluenza etc) in <60 minutes...