S100B

Summary

Gene Symbol: S100B
Description: S100 calcium binding protein B
Alias: NEF, S100, S100-B, S100beta, protein S100-B, S-100 calcium-binding protein, beta chain, S-100 protein subunit beta, S100 calcium-binding protein, beta (neural)
Species: human

Top Publications

  1. ncbi A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex
    Kimberly A McClintock
    Department of Biochemistry and McLaughlin Macromolecular Structure Facility, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 278:6251-7. 2003
  2. ncbi S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
  3. ncbi CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 277:28848-52. 2002
  4. ncbi Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression
    M Fukushi
    Department of Microbiology, School of Medicine, Tokyo Medical and Dental University, Japan
    FEBS Lett 442:83-8. 1999
  5. doi Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics
    Ling Yan Qi
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Neurosci Lett 462:113-7. 2009
  6. ncbi The dynamics of serum tumor markers in predicting metastatic uveal melanoma (part 1)
    Vivian Barak
    Immunology Laboratory for Tumor Diagnosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anticancer Res 31:345-9. 2011
  7. ncbi Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury
    Giuseppe Esposito
    Department of Human Physiology and Pharmacology, Vittorio Erspamer Faculty of Pharmacy, University of Rome La Sapienza, Rome, Italy
    Hum Mol Genet 17:440-57. 2008
  8. doi Dynamics of S100B release into serum and cerebrospinal fluid following acute brain injury
    A Kleindienst
    Department of Neurosurgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 106:247-50. 2010
  9. doi Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studies
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    J Affect Disord 134:32-8. 2011
  10. ncbi Candidate gene analysis of 21q22: support for S100B as a susceptibility gene for bipolar affective disorder with psychosis
    S Roche
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:1094-6. 2007

Research Grants

  1. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
  2. CONSEQUENCES OF NEF EXPRESSION ON CNS PATHOLOGY
    Nora Sarvetnick; Fiscal Year: 2005
  3. Irina A Buhimschi; Fiscal Year: 2014
  4. 950 MHz NMR Spectrometer with Cryogenic Probe
    DAVID JOSEPH WEBER; Fiscal Year: 2010
  5. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
  6. Claudio Fiocchi; Fiscal Year: 2015
  7. Protein dynamics of calcium-S100A5 in the presence and absence of target peptide
    Melissa A Liriano; Fiscal Year: 2012
  8. Targeting RAGE/Abeta interaction with single chain monoclonal antibodies
    Estelle Leclerc; Fiscal Year: 2012
  9. Structure of calcyclin binding protein-S100A6 complex
    Walter Chazin; Fiscal Year: 2004
  10. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010

Detail Information

Publications243 found, 100 shown here

  1. ncbi A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex
    Kimberly A McClintock
    Department of Biochemistry and McLaughlin Macromolecular Structure Facility, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 278:6251-7. 2003
    The Alzheimer-linked neural protein S100B is a signaling molecule shown to control the assembly of intermediate filament proteins in a calcium-sensitive manner...
  2. ncbi S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
    ..b>S100B, a calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation...
  3. ncbi CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 277:28848-52. 2002
    ..Using CacyBP/SIP affinity chromatography, we found that S100B from the brain extract binds to CacyBP/SIP in a Ca2+-dependent manner...
  4. ncbi Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression
    M Fukushi
    Department of Microbiology, School of Medicine, Tokyo Medical and Dental University, Japan
    FEBS Lett 442:83-8. 1999
    The nef gene of human and simian immunodeficiency virus is a key factor in acquired immunodeficiency syndrome pathogenesis and virus replication...
  5. doi Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics
    Ling Yan Qi
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Neurosci Lett 462:113-7. 2009
    b>S100B is a calcium-binding protein, mainly produced and secreted by astrocytes, and it mediates the interaction among glial cells and between glial cells and neurons...
  6. ncbi The dynamics of serum tumor markers in predicting metastatic uveal melanoma (part 1)
    Vivian Barak
    Immunology Laboratory for Tumor Diagnosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anticancer Res 31:345-9. 2011
    ....
  7. ncbi Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury
    Giuseppe Esposito
    Department of Human Physiology and Pharmacology, Vittorio Erspamer Faculty of Pharmacy, University of Rome La Sapienza, Rome, Italy
    Hum Mol Genet 17:440-57. 2008
    ..Network analyses suggested that upregulated expression of chromosome 21 genes such as S100B and amyloid precursor protein activated the stress response kinase pathways, and furthermore, could be linked to ..
  8. doi Dynamics of S100B release into serum and cerebrospinal fluid following acute brain injury
    A Kleindienst
    Department of Neurosurgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Acta Neurochir Suppl 106:247-50. 2010
    High S100B serum levels are considered to reflect brain injury severity. However, the dynamics of S100B passage from the cerebral compartment into the blood remain unclear...
  9. doi Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studies
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    J Affect Disord 134:32-8. 2011
    ..Whereas in young subjects with mood disorders, glial cell density or glial cell numbers are reduced, they are increased in elderly subjects...
  10. ncbi Candidate gene analysis of 21q22: support for S100B as a susceptibility gene for bipolar affective disorder with psychosis
    S Roche
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 144:1094-6. 2007
    ..Although this linkage only approaches significance, the peak marker is located 12 Kb upstream of S100B, a neurotrophic factor implicated in the pathology of psychiatric disorders, including BPAD and schizophrenia...
  11. pmc Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins
    T A Millward
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4058 Basel
    EMBO J 17:5913-22. 1998
    ..In vitro, S100B binds directly to and activates Ndr in a Ca2+-dependent manner...
  12. ncbi Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease
    A Petzold
    Institute of Neurology, Department of Neuroinflammation, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 336:167-70. 2003
    b>S100B is a predominantly astrocytic protein with dose-dependent cytotoxic and neurotrophic properties encoded on chromosome 21q22.3...
  13. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.
  14. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
    b>S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues...
  15. ncbi Structure of the negative regulatory domain of p53 bound to S100B(betabeta)
    R R Rustandi
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene Street, Baltimore, Maryland 21201, USA
    Nat Struct Biol 7:570-4. 2000
    A Ca2+ dependent conformational change in dimeric S100B(betabeta) is required for it to bind p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain...
  16. ncbi Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
    Keith G Inman
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N Greene St, Baltimore, MD 21201, USA
    J Mol Biol 324:1003-14. 2002
    The solution NMR structure is reported for Ca(2+)-loaded S100B bound to a 12-residue peptide, TRTK-12, from the actin capping protein CapZ (alpha1 or alpha2 subunit, residues 265-276: TRTKIDWNKILS)...
  17. ncbi Serum S100B is suitable for prediction and monitoring of response to chemoimmunotherapy in metastatic malignant melanoma
    A P Hamberg
    The Netherlands Cancer Institute Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands
    Melanoma Res 13:45-9. 2003
    Serum S100B and lactate dehydrogenase (LDH) levels were evaluated for their ability to predict response in patients with metastatic malignant melanoma and to determine their usefulness in monitoring the results of chemoimmunotherapy...
  18. ncbi S100B in brain damage and neurodegeneration
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Microsc Res Tech 60:614-32. 2003
    b>S100B is a calcium-binding peptide produced mainly by astrocytes that exert paracrine and autocrine effects on neurons and glia...
  19. ncbi Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins
    Marcin Nowotny
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 278:26923-8. 2003
    ..Sgt1 binds not only to S100A6 but also to S100B and S100P, other members of the S100 family...
  20. ncbi Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase
    Shibani Bhattacharya
    Department of Biochemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 42:14416-26. 2003
    ..The activity of NDR kinase is modulated in a Ca(2+)/S100B-dependent manner by phosphorylation of Ser281 in the catalytic domain and Thr444 in the C-terminal regulatory ..
  21. ncbi S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 29:1004-11. 2004
    b>S100B, a calcium-binding protein produced by astroglial cells, mediates paracrine and autocrine effects on neurons and glial cells...
  22. ncbi SNPs and haplotypes in the S100B gene reveal association with schizophrenia
    Jixia Liu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China
    Biochem Biophys Res Commun 328:335-41. 2005
    The S100B gene locates in 21q22.3 and produces neurotrophin mainly in astrocytes of CNS which can act as an extensive marker of glial cell integrity...
  23. ncbi Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B
    Paul T Wilder
    Department of Biochemistry and Molecular Biology, The University of Maryland School of Medicine, 108 N Greene Street, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1763:1284-97. 2006
    b>S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its biological effect by binding and affecting various target proteins...
  24. pmc Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neurones
    J Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Neurol Neurosurg Psychiatry 77:1284-7. 2006
    To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia.
  25. ncbi S100B in neuropathologic states: the CRP of the brain?
    Jon Sen
    Institute of Neurology, University College London, Queen Square, London, United Kingdom
    J Neurosci Res 85:1373-80. 2007
    In recent years there has been a proliferation of interest in the brain-specific protein S100B, its many physiologic roles, and its behaviour in various neuropathologic conditions...
  26. ncbi Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly
    J C Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 12:870-80. 2007
    Variations in the S100beta gene may be instrumental in producing a continuum from mild cognitive decline to overt dementia...
  27. ncbi S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains
    Estelle Leclerc
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    J Biol Chem 282:31317-31. 2007
    ..Here we compared the interaction of two S100 proteins, S100B and S100A6, with RAGE by in vitro assay and in culture of human SH-SY5Y neuroblastoma cells...
  28. ncbi Evaluation of an alternative S100b assay for use in cardiac surgery: relationship with microemboli and neuropsychological outcome
    D C Whitaker
    Centre for Behavioural and Social Sciences in Medicine, University College London, UK
    Perfusion 22:267-72. 2007
    The aim of the study was to investigate the relationship between S100b release, neuropsychological outcome and cerebral microemboli...
  29. doi Analysis of the structure of human apo-S100B at low temperature indicates a unimodal conformational distribution is adopted by calcium-free S100 proteins
    Shahid Malik
    Department of Biochemistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Proteins 73:28-42. 2008
    b>S100B is one of the best-characterized members of the calcium-signaling S100 protein family. Most S100 proteins are dimeric, with each monomer containing two EF-hand calcium-binding sites (EF1, EF2)...
  30. doi Serum levels of S100B are decreased in chronic starvation and normalize with weight gain
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Neural Transm (Vienna) 115:937-40. 2008
    b>S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells...
  31. doi Biological and methodological features of the measurement of S100B, a putative marker of brain injury
    Carlos Alberto Goncalves
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Biochem 41:755-63. 2008
    The S100B astroglial protein is widely used as a parameter of glial activation and/or death in several conditions of brain injury...
  32. pmc S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells
    Giuseppe Esposito
    Department of Human Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy
    J Cell Mol Med 12:914-27. 2008
    Previous studies suggest that levels of the astrocyte-derived S100B protein, such as those occurring in brain extra-cellular spaces consequent to persistent astroglial activation, may have a pathogenetic role in Alzheimer's disease (AD)...
  33. doi A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGE
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Biol Psychiatry 65:1107-10. 2009
    Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE)...
  34. doi Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:291-7. 2010
    Several lines of evidence suggest an important role of the S100B protein and its coding gene in different neuropathological and psychiatric disorders like dementia, bipolar affective disorders and schizophrenia...
  35. doi S100B serum levels and word memory processing in remitted major depression as reflected by brain potentials
    Yuanyuan Zhang
    Clinic for Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Neuropsychobiology 59:172-7. 2009
    ..This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been shown to be ..
  36. doi S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Psychoneuroendocrinology 35:321-4. 2010
    Elevated blood levels of S100B in neuropsychiatric disorders have so far been mainly attributed to glial pathologies. However, increases or dysfunction of adipose tissue may be alternatively responsible...
  37. pmc Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease
    Takashi Mori
    Department of Medical Science, Saitama Medical Center and University, Kawagoe, Saitama, Japan
    Glia 58:300-14. 2010
    ..One such molecule, S100B, is highly expressed by reactive astrocytes in close vicinity of beta-amyloid deposits...
  38. pmc Serum S100B: a potential biomarker for suicidality in adolescents?
    Tatiana Falcone
    Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11089. 2010
    ..Others reported a possible link between inflammation, a microgliosis and the blood-brain barrier (BBB) in suicidal patients. Serum S100B is a marker of BBB function commonly used to study cerebrovascular wall function.
  39. pmc The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma
    Jing Lin
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:27487-98. 2010
    The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study...
  40. pmc Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke
    Christopher Beer
    Western Australian Centre for Health and Ageing, University of Western Australia, Australia
    J Neuroinflammation 7:71. 2010
    ..We aimed to determine if systemic markers of vascular dysfunction and inflammation are independently associated with concentrations of the astroglial protein S100B, a marker of brain injury, in participants with acute ischaemic stroke.
  41. doi Genetic variability within the S100B gene influences the personality trait self-directedness
    Petra Suchankova
    Institute of Neuroscience and Physiology at the Sahlgrenska Academy, Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
    Psychoneuroendocrinology 36:919-23. 2011
    Elevated serum levels of S100B have proven useful as an indicator of brain-injury but have also been shown in patients diagnosed with psychiatric disorders...
  42. doi Human CD8(+) T cells and NK cells express and secrete S100B upon stimulation
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 25:1233-41. 2011
    Previous studies have demonstrated the utility of S100B as a surrogate marker of brain-related pathologies, e.g. neuropsychiatric disorders, and melanoma progression, which have an inflammatory component...
  43. doi Functional assessment of a promoter polymorphism in S100B, a putative risk variant for bipolar disorder
    Elif Dagdan
    Smurfit Institute of Genetics, Trinity College Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 156:691-9. 2011
    Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZ). S100B protein levels are elevated in serum of patients with both disorders compared to controls...
  44. pmc Role of serum S100B and PET-CT in follow-up of patients with cutaneous melanoma
    Barbara Peric
    Institute of Oncology, Ljubljana, Slovenia
    BMC Cancer 11:328. 2011
    ..In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and ..
  45. doi S100B gene polymorphisms predict prefrontal spatial function in both schizophrenia patients and healthy individuals
    Jinguo Zhai
    School of Mental Health, Jining Medical University, 45 Jianshe South Road, Jining 272013, Shandong Province, PR China
    Schizophr Res 134:89-94. 2012
    Animal studies have strongly implicated a role of S100B in spatial ability and our recent study of humans found that S100B gene polymorphisms (rs9722, rs1051169, and rs2839357) were associated with schizophrenia patients' spatial ability ..
  46. doi Increased S100B+ NK cell counts in acutely ill schizophrenia patients are correlated with the free cortisol index, but not with S100B serum levels
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:564-7. 2012
    Several studies have provided evidence for increased S100B serum concentrations in schizophrenia...
  47. pmc Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis
    B Weide
    Department of Dermatology, Center for Dermatooncology, University Medical Center, Liebermeisterstrasse 25, Tubingen 72076, Germany
    Br J Cancer 107:422-8. 2012
    ..Established prognostic factors are of limited value to predict long-term survival and benefit from metastasectomy in advanced melanoma. This study aimed to identify prognostic factors in patients with distant metastasis...
  48. pmc Validating serum S100B and neuron-specific enolase as biomarkers for the human brain - a combined serum, gene expression and MRI study
    Daniel Paolo Streitbürger
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 7:e43284. 2012
    ..In particular the glial protein S100B, a neuro- and gliotrophin inducing plasticity, seems to be involved in the pathogenesis and treatment of ..
  49. doi S100B and schizophrenia
    Silvia Yelmo-Cruz
    Department of Psychiatry, University Hospital of the Canary Islands, La Laguna, Spain
    Psychiatry Clin Neurosci 67:67-75. 2013
    ..In the last 2 decades, the S100B protein has made its own room in this area of research...
  50. pmc Levels of S100B are raised in female patients with schizophrenia
    Kara O'Connell
    Molecular Neuropharmacology, Department of Physiology, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    BMC Psychiatry 13:146. 2013
    The neurotrophic factor, S100B, is released primarily from astrocytes, with serum and CSF levels of S100B reported as altered in schizophrenia. However, many of these reports are contradictory...
  51. doi S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study
    Tomasz Gos
    Department of Psychiatry, University of Magdeburg, Germany Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland
    J Psychiatr Res 47:1694-9. 2013
    ..In this context, it has been hypothesized that elevated S100B serum and cerebrospinal fluid levels may represent a suitable surrogate marker...
  52. pmc Replicated evidence of absence of association between serum S100B and (risk of) psychotic disorder
    Christine van der Leeuw
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 8:e82535. 2013
    b>S100B is a potential marker of neurological and psychiatric illness. In schizophrenia, increased S100B levels, as well as associations with acute positive and persisting negative symptoms, have been reported...
  53. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    b>S100B is considered an astrocytic in-situ marker and protein levels in cerebrospinal fluid (CSF) or serum are often used as biomarker for astrocytic damage or dysfunction. However, studies on S100B in the human brain are rare...
  54. pmc Structural and functional insights into RAGE activation by multimeric S100B
    Thorsten Ostendorp
    Fachbereich Biologie, Mathematisch Naturwissenschaftliche Sektion, Universitat Konstanz, Konstanz, Germany
    EMBO J 26:3868-78. 2007
    ..The EF-hand protein S100B is highly expressed in human brain...
  55. doi Risk variants in the S100B gene, associated with elevated S100B levels, are also associated with visuospatial disability of schizophrenia
    Jinguo Zhai
    School of Mental Health, Jining Medical University, Jining 272013, Shandong Province, People s Republic of China
    Behav Brain Res 217:363-8. 2011
    Rs9722 and rs1051169 have been reported as affecting the levels of S100B in the serum or the brain, and haplotypes containing these two SNPs have been associated with schizophrenia...
  56. ncbi Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta
    R Jensen
    J Neurochem 45:700-5. 1985
    Two major components of human brain S100 fraction were purified by HPLC and an amino acid sequence was elucidated for the S100 beta component...
  57. ncbi Purification, characterization and ion binding properties of human brain S100b protein
    J Baudier
    Biochim Biophys Acta 790:164-73. 1984
    Human brain S100b (beta beta) protein was purified using zinc-dependent affinity chromatography on phenyl-Sepharose...
  58. ncbi Serum S100B concentrations are increased after closed head injury in children: a preliminary study
    Rachel Pardes Berger
    Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 19:1405-9. 2002
    ..b>S100B is a protein that is specific to astrocytes...
  59. ncbi Serum S 100 B: a marker of brain damage in traumatic brain injury with and without multiple trauma
    Linda E Pelinka
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Research Center for Traumatology of the Austrian Workers Compensation Board, Vienna, Austria
    Shock 19:195-200. 2003
    ..693-0.783). Thus, though S 100 B may be a reliable marker of brain damage in TBI without multiple trauma 24 h after trauma and thereafter, it appears to be less reliable in TBI with multiple trauma...
  60. doi S100B transgenic mice develop features of Parkinson's disease
    Jialin Liu
    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Panjiayuan No 5, Chaoyang, Beijing, P R China
    Arch Med Res 42:1-7. 2011
    ..Until now, the cause and mechanism of PD are unknown, making further studies necessary. We undertook this study to establish the brain-specific S100B gene transgenic mice and investigate the role of S100B in the development of PD.
  61. pmc The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 7:e1001315. 2011
    ..Here we reveal a previously unknown mechanism by which the danger molecule S100B integrates pathogen- and danger-sensing pathways to restrain inflammation...
  62. ncbi Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C
    J Baudier
    Biochemistry 26:2886-93. 1987
    To gauge similarities between S100b protein and calmodulin, interactions were observed between S100b and melittin and between S100b and tau, the microtubule-associated proteins...
  63. ncbi Assignment and secondary structure of calcium-bound human S100B
    S P Smith
    Department of Biochemistry, University of Western Ontario, London, Canada
    J Biomol NMR 10:77-88. 1997
    The NMR assignments of backbone 1H, 13C, and 15N resonances for calcium-bound human S100B were completed via heteronuclear multidimensional NMR spectroscopic techniques...
  64. ncbi Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments
    M Garbuglia
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Cell Calcium 24:177-91. 1998
    ..phospholipid- and membrane-binding proteins, interacts with the Ca(2+)-regulated EF-hand proteins, S100A1 and S100B, and blocks the ability of these two proteins to inhibit the assembly of desmin and glial fibrillary acidic ..
  65. ncbi Circulating S100beta protein is increased in intrauterine growth-retarded fetuses
    Diego Gazzolo
    Department of Pediatrics, Giannina Gaslini Children s University Hospital, Genoa, Italy
    Pediatr Res 51:215-9. 2002
    To determine whether S100beta, an acidic calcium-binding protein previously demonstrated as a reliable indicator of a brain lesion, could be helpful in the detection of brain distress in intrauterine growth-retarded (IUGR) fetuses, we ..
  66. ncbi The C-terminus and linker region of S100B exert dual control on protein-protein interactions with TRTK-12
    Kimberly A McClintock
    Department of Biochemistry and McLaughlin Macromolecular Structure Facility, The University of Western Ontario, London, Ontario, Canada
    Biochemistry 41:5421-8. 2002
    S100B, an EF-hand calcium-binding protein composed of two S100beta monomers, undergoes a calcium-dependent conformational change that provides a surface for target interactions...
  67. ncbi Human milk contains S100B protein
    Diego Gazzolo
    Department of Pediatrics, Giannina Gaslini Children s University Hospital, I 16147 Genoa, Italy
    Biochim Biophys Acta 1619:209-12. 2003
    The present study constitutes the first finding of the calcium-binding protein S100B and of its mRNA in human milk, as revealed by a quantitative immunoluminometric assay, by Western blot analysis and by reverse transcription-polymerase ..
  68. ncbi Ontogenetic changes in serum S100B in Down syndrome patients
    Cristina B O Netto
    Dept Bioquimica, ICBS, UFRGS, Rua Euripedes Monteiro Duarte 10 305, Porto Alegre, RS, 90830 250, Brazil
    Clin Biochem 38:433-5. 2005
    It has been shown that Down syndrome (DS) patients have elevated S100B levels in brain tissue.
  69. pmc Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function
    Yong Liu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Mol Pharmacol 74:371-8. 2008
    b>S100B is a calcium-binding protein with both extracellular and intracellular regulatory activities in the mammalian brain. We have identified a novel interaction between S100B and the dopamine D(2) receptor...
  70. doi No association of the rs9722 C >T in the S100B gene and susceptibility to major depression in a Chinese population
    Kun Yang
    Mental Health Institute of the Second Xiangya Hospital, Central Southern University, Changsha, P R China
    Genet Test 12:487-9. 2008
    Astroglial-derived protein S100B is known to play important roles in axonal growth, neural plasticity, and energy regulation...
  71. doi The effects of gender and numbers of depressive episodes on serum S100B levels in patients with major depression
    Kun Yang
    Department of Psychiatry, Tianjin Medical University, 300070, Tianjin, People s Republic of China
    J Neural Transm (Vienna) 115:1687-94. 2008
    b>S100B protein is a calcium-binding protein mostly derived from glial cells, which exerts trophic or toxic effects on neural cell depending on its concentration...
  72. ncbi Association study of astrocyte-derived protein S100B gene polymorphisms with major depressive disorder in Chinese people
    Kun Yang
    Mental Health Institute of the Second Xiangya Hospital, Central Southern University, Changsha, China
    Can J Psychiatry 54:312-9. 2009
    Astroglial-derived protein S100B is known to play important roles in axonal growth, neural plasticity, and energy regulation. Disturbance of these neurodevelopmental processes is proposed as one possible etiology for mood disorder...
  73. pmc S-100B concentrations predict disease-free survival in stage III melanoma patients
    S Kruijff
    Division of Surgical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Ann Surg Oncol 16:3455-62. 2009
    ..Elevation of the tumor marker S-100B in melanoma patients is a highly specific indicator of recurrence...
  74. pmc Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism--effects of medication
    Robert D Oades
    Clinic for Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Behav Brain Funct 6:29. 2010
    ..This could be explained in terms of an impaired glial supply of energy to support neuronal activity...
  75. ncbi Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients
    Sascha Gross
    Kidney Center, Dept of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands
    Med Sci Monit 16:CR318-24. 2010
    b>S100B is a prominent cell damage marker which can lead to sustained pro-inflammatory signaling...
  76. doi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Because S100B is expressed in astrocytes and oligodendrocytes, its concentration in cerebrospinal fluid (CSF) or serum has been ..
  77. pmc Identification of calcium-independent and calcium-enhanced binding between S100B and the dopamine D2 receptor
    Brian R Dempsey
    Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochemistry 50:9056-65. 2011
    b>S100B is a dimeric EF-hand protein that undergoes a calcium-induced conformational change and exposes a hydrophobic protein-binding surface...
  78. ncbi Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999
    A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises 19 members that are differentially expressed in a large number of cell types...
  79. ncbi Immunohistochemical distribution of S-100 protein and subunits (S100-alpha and S100-beta) in the swamp-type water buffalo (Bubalus bubalis) testis
    M B C Cruzana
    Laboratory of Veterinary Anatomy, Department of Basic Veterinary Sciences, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Andrologia 35:142-5. 2003
    The distribution and localization of S-100 protein (S-100) and its subunits (S100-alpha and S100-beta) in the testis of swamp-type water buffalo were investigated using immunohistochemistry...
  80. ncbi Detection of S100 protein from prostatic cancer patients using anti-S100 protein antibody immobilized on POS-PVA discs
    Mario R Melo-Júnior
    Laboratorio de Imunopatologia Keizo Asami, LIKA, Universidade Federal de Pernambuco UFPE, Pernambuco, Brazil
    Biotechnol Bioeng 97:182-7. 2007
    The S100 proteins have been extensively used as cancer biomarkers...
  81. pmc Structural and functional diversification in the teleost S100 family of calcium-binding proteins
    Andreas M Kraemer
    Institute of Genetics, University of Cologne, Zuelpicher Strasse 47, 50674 Cologne, Germany
    BMC Evol Biol 8:48. 2008
    Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling...
  82. ncbi RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 7:711-24. 2007
    ..The receptor for advanced glycation end products (RAGE) has been shown to transduce extracellular effects of S100B, S100A4, S100A6, S100A11, S100A12, S100A13 and S100P...
  83. ncbi Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions
    R Boni
    Department of Dermatology, University of Zurich, Switzerland
    Br J Dermatol 137:39-43. 1997
    ..was to evaluate the expression of the Ca(2+)-binding S100 proteins S100A1, S100A2, S100A3, S100A4, S100A6 and S100B in normal skin. These immunohistochemical staining patterns were compared with those in melanocytic lesions...
  84. ncbi S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
    R Donato
    Department of Experimental and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Int J Biochem Cell Biol 33:637-68. 2001
    ..A cell surface receptor, RAGE, has been identified on inflammatory cells and neurons for S100A12 and S100B, which transduces S100A12 and S100B effects...
  85. ncbi Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy
    A C Drohat
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore 21201, USA
    Biochemistry 35:11577-88. 1996
    b>S100B(beta beta), a member of the S100 protein family, is a Ca(2+)-binding protein with noncovalent interactions at its dimer interface...
  86. ncbi Pathologies involving the S100 proteins and RAGE
    C W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Subcell Biochem 45:93-138. 2007
    The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup within the superfamily of EF-hand Ca2(+)-binding proteins Generally, S100 proteins are organized as tight homodimers (some as heterodimers)...
  87. doi Direct inhibitory and indirect stimulatory effects of RAGE ligand S100 on sRANKL-induced osteoclastogenesis
    Tomohiko Yoshida
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Cell Biochem 107:917-25. 2009
    ..b>S100 proteins are ligands for the receptor of AGEs (RAGE)...
  88. ncbi Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat
    Andrea Kleindienst
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 21:541-7. 2004
    Elevated serum S100B levels have been shown to be a predictor of poor outcome after traumatic brain injury (TBI). Experimental data, on the other hand, demonstrate a neuroprotective and neurotrophic effect of this calcium-binding protein...
  89. ncbi A critical analysis of the role of the neurotrophic protein S100B in acute brain injury
    Andrea Kleindienst
    Department of Neurosurgery, Georg August University, Gottingen, Germany
    J Neurotrauma 23:1185-200. 2006
    We provide a critical analysis of the relevance of S100B in acute brain injury emphazising the beneficial effect of its biological properties...
  90. ncbi Metaplastic breast carcinoma invading chest wall
    J M Harb
    Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
    Ultrastruct Pathol 19:439-43. 1995
    ..Smooth muscle actin, S100, and vimentin were diffusely positive in the stromal cells...
  91. ncbi [An atypical rhabdoid/teratoid tumor. A presentation of three cases and review of the literature]
    T Cuesta-Mejías
    Departamento de Patología Quirúrgica, American British Cowdray Medical Center, Mexico DF
    Rev Neurol 32:618-24. 2001
    ..This is more than simply nosological importance, since the five year survival expected in medulloblastomas is considerably better than the 11 months (average) seen in rhabdoid/teratoid tumors...
  92. ncbi Spiroplasmas are the causal agents of citrus little-leaf disease
    P G Markham
    John Innes Institute, Colney Lane, Norwich
    Ann Appl Biol 78:49-57. 1974
    ..b>S100) and sweet orange (Citrus sinensis cv. Valencia)...
  93. pmc S100B as a surrogate marker for successful clot lysis in hyperacute middle cerebral artery occlusion
    C Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurol Neurosurg Psychiatry 74:322-5. 2003
    The astroglial protein S100B is a marker of cerebral tissue damage...
  94. ncbi Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases
    S A Pileri
    Service of Pathologic Anatomy and Hematopathology, Institute of Haematology and Clinical Oncology L e A Seràgnoli, Bologna University, Italy
    Histopathology 41:1-29. 2002
    ..with histiocytes (CD68, lysozyme (LYS)), Langerhans cells (CD1a), follicular dendritic cells (FDC: CD21, CD35) and S100 protein...
  95. ncbi Characterization of N-nitrosourea-induced tumors of the nervous system; their prospective value for studies of neurocarcinogenesis and brain tumor therapy
    A Koestner
    Department of Pathology, Michigan State University, East Lansing 48824
    Toxicol Pathol 18:186-92. 1990
    ..old rats, MNU and ENU-induced astrocytomas can be readily identified with well established biomarkers such as the S100 protein and particularly GFAP (glial fibrillary acidic protein)...
  96. ncbi Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients
    G Ferrara
    Servizio di Anatomia Patologica, Azienda Ospedaliera Gaetano Rummo, Benevento, Italy
    Tumori 81:144-7. 1995
    ..immunohistochemical profile of the neoplastic cells (positivity for cytokeratins, and negativity for CD antigens, S100 protein, placental alkaline phosphatase, and neuroendocrine markers) represent the basic pathologic features of a ..
  97. ncbi [Clinical values of detection of serum levels of S100B and NSE in diagnosis of brain injuries at early period after cardiopulmonary bypass]
    Xing Hua Gu
    Department of Cardiac Surgery, Qilu Hospital of Shandong University, Jinan 250012, China
    Zhonghua Yi Xue Za Zhi 87:975-7. 2007
    To investigate the clinical values of detecting the blood serum levels of S100B and neuron-specific enolase (NSE) in diagnosis of brain injuries at early period after cardiopulmonary bypass (CPB).
  98. ncbi Unusual topographical pattern of proximal astrogliosis around a cortical devascularizing lesion
    Kai Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Neurosci Res 73:497-506. 2003
    ..Four markers were used to identify the glial response surrounding the lesion. The antibody used against S100beta marked the largest astrocytic pool in the gray matter of the cerebral cortex; only approximately 5% of astrocytes ..
  99. ncbi [Effect of hydroxyethyl starch 130/0.4 on S100B protein level and cerebral oxygen metabolism in open cardiac surgery under cardiopulmonary bypass]
    Zhi bing Pi
    Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Yi Xue Za Zhi 87:1908-11. 2007
    To observe the effect of hydroxyethyl starch (HES) 130/0.4 on S100B protein level and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary bypass (CPB) and to explore whether it has the protective effect of 6%..
  100. ncbi Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations
    A Petzold
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    Brain 125:1462-73. 2002
    ..b>S100B, ferritin and glial-fibrillary acidic protein (GFAP) were quantified in CSF and brain-tissue homogenate by ELISA (..

Research Grants67

  1. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..b>S100 proteins are an important class of protein that are required for calcium signal transduction...
  2. CONSEQUENCES OF NEF EXPRESSION ON CNS PATHOLOGY
    Nora Sarvetnick; Fiscal Year: 2005
    ..Recent fascinating research has focused on the pathogenic potential of the HIV NEF gene product...
  3. Irina A Buhimschi; Fiscal Year: 2014
    ..e., s100 a12, s100a8, s100b)...
  4. 950 MHz NMR Spectrometer with Cryogenic Probe
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..Dr. David J. Weber (UMB), Structure/function and inhibition of protein-protein complexes involving S100 proteins;2. Dr. Michael Summers (UMBC) NMR studies of retroviral genome packaging;3. Dr...
  5. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
    ..b>S100 proteins are low molecular weight, acidic, calcium-binding proteins that play an important role in various cellular ..
  6. Claudio Fiocchi; Fiscal Year: 2015
    ..protein 1 (HMGB1), nucleic acids, uric acid, degradation products of the extracellular matrix, calcium-binding S100 proteins, and many others...
  7. Protein dynamics of calcium-S100A5 in the presence and absence of target peptide
    Melissa A Liriano; Fiscal Year: 2012
    ..ofthe molecular interactions between SI 00 proteins and targets can provide objectives for novel therapeutics, such as the ongoing drug design program in the Weber lab for inhibiting S100B as a means to treat malignant melanoma.
  8. Targeting RAGE/Abeta interaction with single chain monoclonal antibodies
    Estelle Leclerc; Fiscal Year: 2012
    ..We showed that the recombinant light chain could bind to RAGE and displace RAGE ligand S100B in vitro...
  9. Structure of calcyclin binding protein-S100A6 complex
    Walter Chazin; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) S100 proteins constitute a major subfamily of EF-hand Ca2+-binding proteins that are characterized by cell type-specific expression and unusually high abundance in a variety of disease states, ..
  10. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In the last four years, our lab has demonstrated that: (i). S100B protein binds to wild-type p53 in primary malignant melanoma;(ii) S100B down-regulates p53 protein levels and its tumor suppression ..
  11. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..of inflammation and brain injury, the peripheral benzodiazepine receptor (PBR) and the neurotrophic protein, S100B. Molecular imaging (MI) is an emerging discipline that tries to non-invasively visualize specific biomolecules in ..
  12. NEF FUNCTION
    J Victor Garcia Martinez; Fiscal Year: 2010
    ..Tat and rev are required for virus replication in all settings. The vif, vpr, vpu, and nef genes are generally not required for viral replication in vitro...
  13. Sharilyn Almodovar; Fiscal Year: 2014
    ..Our group has demonstrated that HIV Nef is associated with vascular remodeling and lumen- obliterative PAH-like lesions in the lungs of SHIV-nef-infected ..
  14. IN VITRO AND IN VIVO FUNCTION OF HIV AND SIV NEF GENES
    Paul Luciw; Fiscal Year: 2002
    ..virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) encode a gene, designated nef (negative effector), that is dispensable for viral replication in vitro (i.e., in tissue culture cells)...
  15. Alterations in Lung Microbiome in Acute and Chronic HIV infection
    Andrew P Fontenot; Fiscal Year: 2013
    ..Studies of HIV-Associated Lung Infections and Complications" program, we initiated a systematic analysis of nef sequences evolution in the lung and periphery using high-throughput sequencing platforms...
  16. Characterization of Nef vesicles and their effect on T cells and macrophage
    Michael D Powell; Fiscal Year: 2012
    ..In this application, we propose to explore what role the viral protein Nef might play in AIDS pathogenesis...
  17. VIVIANA A SIMON; Fiscal Year: 2014
    ..In contrast to our growing knowledge of lentiviral antagonists (APOBEC3: Vif;Tetherin/BST2: Vpu, Nef and Env;SAMHD1: Vpx), we know very little about how HTLV-1 overcomes these blocks...
  18. PATHOGENESIS OF HIV IN CD4 CELLS
    James Hoxie; Fiscal Year: 1993
    ..2). We will evaluate the role of the 3'ORF viral gene product, recently termed NEF, on viral replication during HIV and SIV infection and explore potential effects of this protein on infected cells...
  19. MECHANISM OF NEF ACTION IN HIV 1 INFECTION
    Christopher Aiken; Fiscal Year: 2005
    ..1 (HIV-1), the major causative agent of Acquired Immune Deficiency Syndrome (AIDS), encodes the accessory protein Nef. Nef plays a crucial role in primate lentivirus replication and pathogenesis...
  20. Serum markers of football-related brain concussions: a pilot study
    Damir Janigro; Fiscal Year: 2012
    ..It is therefore significant to detect early BBB changes to predict development of post-concussion brain damage. S100B has emerged as a candidate peripheral biomarker of BBB permeability...
  21. S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIES
    Walter Chazin; Fiscal Year: 2009
    ..To date, structural biology studies on these proteins have provided detailed information on the S100 structure and the response to binding calcium, but little insight into how these proteins affect signaling within a ..
  22. Viral evolution in peropheral macrophages and brain during progression to AIDS
    Marco Salemi; Fiscal Year: 2013
    ..3kb fragment, including gp160, nef and 5'LTR, of the viral genome, as well as some full-length genomes from selected tissues...
  23. Molecular Epidemiology and Natural History of SIVcpz
    Beatrice H Hahn; Fiscal Year: 2013
    ..viruses in wild gorillas (Nature 2006), and found that SIVcpz (like HIV-1) has lost an important function of its Nef protein (Cell 2006;PLoS Pathogens 2008)...
  24. Pathobiology of HIV(SIV)-Induced Angioproliferative Pul*
    Sonia Flores; Fiscal Year: 2009
    ..primarily macrophages providing a potential reservoir of virus and a source of localized viral proteins such as Nef, which can circulate and affect surrounding cells...
  25. Innate Restriction Factor Modulation of Retrovirus-specific Humoral Immunity
    MARIO LUIS SANTIAGO; Fiscal Year: 2013
    ..phenotypes and neutralizing antibody development in rhesus macaques infected with wild-type, Vif-attenuated and Nef-deleted SIVmac239...
  26. Determining the roles(s) of HIV-1 Nef in enhancement of virion infectivity
    MICHELLE J LANG; Fiscal Year: 2011
    HIV-1 Nef has many functions that work to enhance the pathogenicity of HIV and SIV which are important for the progression to AIDS. One such function is the enhancement of infectivity of virions that contain the Nef gene...
  27. Inhibitors of HIV-induced downregulation of HLA class I
    Juan Lama; Fiscal Year: 2013
    ..The viral protein Nef induces MHC-I downmodulation and interferes with the presentation of viral antigens, making HIV-infected cells less ..
  28. David T Evans; Fiscal Year: 2016
    ..Whereas most simian immunodeficiency viruses (SIVs) use Nef to overcome restriction by tetherin in their non-human primate hosts, the Vpu protein of HIV-1 and the Env protein ..
  29. Edward Barker; Fiscal Year: 2016
    ..NK cells do not effectively lyse HIV-infected cells despite the ability of HIV-1 Nef to down modulate the ligands for NK cell inhibitory receptors, HLA-A and -B...
  30. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen L Collins; Fiscal Year: 2013
    ..To this end, the HIV Nef protein is an important and under-developed drug target...
  31. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2009
    ..encoding codon-optimized SIV gag, env (native and modified for proteosome degradation), and a (detoxified) rev/nef/tat chimera under the control of promoters of different kinetic classes, and assess the level and pattern of SIV Ag ..
  32. DAVID H O'CONNOR; Fiscal Year: 2015
    ..understanding of SIV sequence dynamics: 1) We will determine whether bulk lymphocytes transferred from SIVmac239?nef immunized donors significantly decrease setpoint SIVmac239 viremia...
  33. Dan H Barouch; Fiscal Year: 2016
    ..The failure of an Ad5-Gag/Pol/Nef vaccine in the Step study has led to the development of novel serotype Ad vectors, which are biologically very ..
  34. Ashley T Haase; Fiscal Year: 2015
    ..correlate of the local protection against vaginal challenge conferred by live attenuated SIVmac239[unreadable]nef vaccination...
  35. Vpu inhibits NK cell function through down regulation of NTB-A
    Edward Barker; Fiscal Year: 2011
    ..NK cells do not effectively lyse HIV-infected cells despite the ability of HIV-1 Nef to down modulate the ligands for NK cell inhibitory receptors, HLA-A and -B...
  36. Determining Whether Transient HIV Infection Occurs
    Miles W Cloyd; Fiscal Year: 2010
    ..HIV in the Ab-positive subjects and their source partners by nested PCR and PBMC culture;(3) sequence env and nef genes that are amplified and perform phylogenetic analyses to show relatedness between viruses in putative ..
  37. David I Watkins; Fiscal Year: 2016
    ..To test this hypothesis we will vaccinate eight Mamu-B*08 positive macaques with a small region of Nef encoding the immunodominant Mamu- B*08-restricted Nef RL10 epitope and then challenge them with a high dose of ..
  38. Simon M Barratt-Boyes; Fiscal Year: 2016
    ..infected with SIVmac251 and treated with antiretroviral therapy or infected with attenuated SIVmac239[unreadable]nef. With this full spectrum of outcomes of infection we will be able to put into context the relevance of the DC and ..
  39. Vif-specific CD8 responses in individuals that control HIV replication
    David I Watkins; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We have recently discovered that Nef- and Vif-specific CD8 responses in Indian macaques control viral replication of the highly pathogenic SIVmac239 isolate...
  40. Replicative fitness of SIV variants
    Jason T Kimata; Fiscal Year: 2010
    ..by which RT mutations increase viral infectivity, and to determine whether the RT infectivity determinant enhances nef expression in resting T-cells. AIMS: To define the relative in vivo fitness of SIVmne variants...
  41. STUDY OF MHC & CTL IN OPIATE-DEPENDENT MONKEYS WITH AIDS
    David Watkins; Fiscal Year: 2002
    ..These investigators will utilize the SIV/macaque model to determine whether nef-specific cytotoxic T lymphocytes (CTL) play a role in selection for new virus variants in vivo...
  42. IMPORTANCE OF DENDRITIC CELLS IN SIV DELTA NEF VACCINES
    Melissa Robbiani; Fiscal Year: 1999
    ..Infection of macaques with an attenuated SIV defective for Nef (SIV delta Nef) results in a low level persistent infection and provides protection from subsequent infection with ..
  43. Regulation of Nef Activities by Phosphorylation
    J Victor Garcia Martinez; Fiscal Year: 2007
    ..In contrast, the vif, vpr, vpu, and nef genes are generally not required for viral replication in different in vitro systems...
  44. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ..of RAGE with its known important ligands, including AGEs, high mobility group box-1 protein (HMGB-1) and S100 calgranulins...
  45. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    ..What is the basis of HIV neurologic deficits? HIV proteins such as gp120, Tat, Vpr and Nef are directly neurotoxic, and may also modulate indirect toxicity by causing functional changes in astroglia and ..
  46. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..using immunohistochemistry, ELISA, and Western blot methods for neuron specific enolase (NSE), astrocytic protein S100B, and ischemia marker vascular endothelial growth factor (VEGF) receptor 2...
  47. JEREL ADAM FIELDS; Fiscal Year: 2014
    ..We found that recombinant HIV negative regulatory factor (Nef) and glycoprotein (gp)120 similarly increase neuronal DRP1 and decrease neuronal Mfn1 and Mfn2...
  48. Nikon TiE Motorized Microscope System For 3D Image Acquisition, Deconvolution, Li
    Robert S Fuller; Fiscal Year: 2010
    ..Collins and coworkers have shown that one way this is accomplished is via the activity of the HIV- 1 Nef protein, which disrupts antigen presentation by altering the intracellular trafficking of MHC- I...
  49. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..the number of cortical somatostatin immunopositive neurons in a transgenic mouse MDDel producing the HIV regulatory nef protein (see preliminary data)...
  50. Roy L Sutliff; Fiscal Year: 2014
    ..Various lines of evidence implicate HIV accessory proteins (Tat, Nef, Vpu) in orchestrating major alterations in the host cellular homeostasis processes such as redox balance, membrane ..
  51. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..mechanism in the etiology of HIV-associated PAH may exist in the effect of HlV-1 secreted proteins, such as Tat, Nef or gp120...
  52. Sheng He Huang; Fiscal Year: 2014
    ..resulted in a synergistic increase in blood levels of circulating BMEC (cBMEC) [UEA+(EC marker)/CD146+(EC marker)/S100B+ (brain marker)] as well as endothelial progenitor cells (EPC)[UEA+/CD146+/CD133+(progenitor cell marker)]...
  53. Regulation of antibody diversification and production in HIV-1 infection
    Andrea Cerutti; Fiscal Year: 2012
    ..In this proposal, we argue that the HIV-1 protein Nef contributes to the genesis of B cell-intrinsic defects arising during HIV-1 infection...
  54. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    STEVEN KYLE GRINSPOON; Fiscal Year: 2013
    ..Furthermore, HIV viral factors are being recognized to possibly contribute to atherogenesis. HIV-1 Nef protein impairs efflux of cholesterol from macrophages by downregulation of ATP binding cassette transporter A1 (..
  55. Maria G Castro; Fiscal Year: 2015
    ..e., S100 calcium binding protein A8 (S100A8) and S100A9, which have been shown to play a critical role in mediating the ..
  56. Design of Degron-based Substrates Capable of E3 Ligase-mediated Ubiquitination
    ADAM THOMAS MELVIN; Fiscal Year: 2013
    ..In Aim 2, substrate ubiquitination will be evaluated using S100 cytosolic lysates first in a model cell system and secondly in myeloid leukemia-based cells such U937, THP-1, K562, ..
  57. Engineered Listeria monocytogenes as an AIDS vaccine
    Judy Lieberman; Fiscal Year: 2009
    ..Attenuated nef and gag constructs boost human CTL responses in vitro...
  58. Immunization Strategies for Autologous HIV Immunotherapy
    Louis D Falo; Fiscal Year: 2012
    ..Specifically, we propose to genetically engineer skin DCs in vivo to both efficiently present patient-specific Nef and Gag antigens, and express enhanced DC1 type polarized immune-stimulatory function essential for optimal ..
  59. Migratory Properties of HIV-infected T Cells in Vivo
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2011
    ..1), and specifically the role of the viral proteins Nef and Env in any alterations of their motile behavior that are observed (subaims 1.2 and 1.3)...
  60. Felipe Diaz-Griffero; Fiscal Year: 2016
    ..synthesis;3) HIV-1 cores isolated from particles produced in the absence of accessory proteins such as vif, vpr or nef exhibit low stability and are poorly infectious due to a defect in vDNA synthesis;4) the use of proteasome ..
  61. THORSTEN ROMAN MEMPEL; Fiscal Year: 2016
    ..1), and specifically the role of the viral proteins Nef and Env in any alterations of their motile behavior that are observed (subaims 1.2 and 1.3)...
  62. Role of APOL1 in HIVAN pathogenesis
    Waldemar Popik; Fiscal Year: 2013
    ..However, findings that HIV-1 Nef recapitulates a HIVAN phenotype in experimental models, suggest that podocytes can be injured by Nef that is ..
  63. Attenuated HIV/TB Vaccine for India
    Uma Devi K Ranganathan; Fiscal Year: 2012
    ..polyfunctional HIV-specific T cell responses after TBC-M4 vaccine (recombinant MVA that encodes env, gag, tat, rev, nef and ?RT gene sequences from subtype C virus isolates) boosting (or vice versa) among sites relevant to protection ..
  64. PATHOGENIC CONVERSION OF ATTENUATED SIV VACCINES
    Earl Sawai; Fiscal Year: 2003
    ..Such studies in juvenile and adult macaques revealed that viral accessory genes, including nef, are important for pathogenesis...
  65. Mechanisms of experimental drug-induced hepatitis
    Dolores Njoku; Fiscal Year: 2007
    ..Hepatitis is induced by immunizing BALB/c mice with a drug hapten-autoantigen, trifluoroacetyl chloride-hepatic S100 (TFA-S100)...
  66. NEF GENE OF HIV-1
    Warner Greene; Fiscal Year: 1999
    The nef gene of the type 1 human immunodeficiency virus (HIV-1) has remained the most enigmatic and controversial of the nine genes comprising this pathogenic human lentivirus...
  67. Developing HIV-1 Nef as a novel drug target
    Joachim Jaeger; Fiscal Year: 2009
    ..The long-term objective of this study is to test and develop HIV-1 Nef as a fully validated drug target to increase therapeutic options for HIV carriers, to combat HAART-related drug ..