S100A8

Summary

Gene Symbol: S100A8
Description: S100 calcium binding protein A8
Alias: 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, protein S100-A8, calgranulin A, calprotectin L1L subunit, cystic fibrosis antigen, leukocyte L1 complex light chain, migration inhibitory factor-related protein 8, urinary stone protein band A
Species: human

Top Publications

  1. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
  2. ncbi Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex
    C Kerkhoff
    Institute of Experimental Dermatology, Munster, Germany
    FEBS Lett 460:134-8. 1999
  3. ncbi S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes
    Takamasa Nukui
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatachou, Okayama 700 8558, Japan
    J Cell Biochem 104:453-64. 2008
  4. pmc Calprotectin--a novel marker of obesity
    Ole Hartvig Mortensen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e7419. 2009
  5. pmc S100A8/A9 activate key genes and pathways in colon tumor progression
    Mie Ichikawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10905 Road to the Cure, San Diego, CA 92121, USA
    Mol Cancer Res 9:133-48. 2011
  6. ncbi Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005
  7. ncbi S100 proteins in Corpora amylacea from normal human brain
    D Hoyaux
    Laboratory of Histopathology, Erasmus University Hospital, Faculty of Medicine, Université Libre de Bruxelles CP 620, 808 Route de Lennik, 1070, Brussels, Belgium
    Brain Res 867:280-8. 2000
  8. pmc Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis
    Yueh Sheng Chen
    Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Arthritis Res Ther 11:R39. 2009
  9. ncbi S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 c
    Ines Eue
    PAN Clinic, Zeppelinstrasse 1, 50667 Köln, Germany
    Int Immunol 14:287-97. 2002
  10. ncbi HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes
    Carle Ryckman
    Centre de Recherche en Infectiologie, Pavillon Centre Hospitalier de l Université Laval, Centre Hospitalier Universitaire de Quebec, and Département de Biologie Médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Immunol 169:3307-13. 2002

Research Grants

  1. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2003
  2. Potential Role of H. Pylori-induced MIF in Gastric Cancer
    ELLEN BESWICK; Fiscal Year: 2009
  3. Richard M Peek; Fiscal Year: 2016
  4. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
  5. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
  6. ANNE MUESCH; Fiscal Year: 2016
  7. Douglas Morgan; Fiscal Year: 2014
  8. Analysis of the H. Pylori cag pathogenicity island
    Timothy L Cover; Fiscal Year: 2012
  9. Lin Feng Chen; Fiscal Year: 2014
  10. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011

Patents

  1. Novel lymphokine related peptides

Detail Information

Publications208 found, 100 shown here

  1. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
    b>S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu during inflammatory conditions...
  2. ncbi Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex
    C Kerkhoff
    Institute of Experimental Dermatology, Munster, Germany
    FEBS Lett 460:134-8. 1999
    Analysis of the calcium-induced arachidonic acid (AA) binding to S100A8/A9 revealed that maximal AA binding was achieved at molar ratios of 1 mol S100A8 and 1 mol S100A9 and for values greater than 3 calciums per EF-hand...
  3. ncbi S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes
    Takamasa Nukui
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatachou, Okayama 700 8558, Japan
    J Cell Biochem 104:453-64. 2008
    b>S100A8 and S100A9 are known to be up-regulated in hyperproliferative and psoriatic epidermis, but their function in epidermal keratinocytes remains largely unknown...
  4. pmc Calprotectin--a novel marker of obesity
    Ole Hartvig Mortensen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e7419. 2009
    The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders...
  5. pmc S100A8/A9 activate key genes and pathways in colon tumor progression
    Mie Ichikawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10905 Road to the Cure, San Diego, CA 92121, USA
    Mol Cancer Res 9:133-48. 2011
    The tumor microenvironment plays an important role in modulating tumor progression. Earlier, we showed that S100A8/A9 proteins secreted by myeloid-derived suppressor cells (MDSC) present within tumors and metastatic sites promote an ..
  6. ncbi Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005
    ..We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate ..
  7. ncbi S100 proteins in Corpora amylacea from normal human brain
    D Hoyaux
    Laboratory of Histopathology, Erasmus University Hospital, Faculty of Medicine, Université Libre de Bruxelles CP 620, 808 Route de Lennik, 1070, Brussels, Belgium
    Brain Res 867:280-8. 2000
    ..by immunohistochemistry, the presence of different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A12 and S100B) in C.A. from normal human brain...
  8. pmc Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis
    Yueh Sheng Chen
    Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Arthritis Res Ther 11:R39. 2009
    ..High concentrations of three of its putative proinflammatory ligands, S100A8/A9 complex (calprotectin), S100A8, and S100A12, are found in rheumatoid arthritis (RA) serum and synovial fluid...
  9. ncbi S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 c
    Ines Eue
    PAN Clinic, Zeppelinstrasse 1, 50667 Köln, Germany
    Int Immunol 14:287-97. 2002
    The natural ligands of the S100 EF hand proteins S100A8 and A9 [myeloid-related proteins 8 and 14] have long been searched for in order to further the understanding of the role of the S100A8/A9-expressing monocyte subpopulation in ..
  10. ncbi HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes
    Carle Ryckman
    Centre de Recherche en Infectiologie, Pavillon Centre Hospitalier de l Université Laval, Centre Hospitalier Universitaire de Quebec, and Département de Biologie Médicale, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Immunol 169:3307-13. 2002
    b>S100A8, S100A9, and S100A12, collectively known as myeloid-related proteins (MRPs), are highly expressed by the myeloid cell lineage and are found in the extracellular milieu during infections and inflammatory conditions...
  11. ncbi Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity
    Nadja Leukert
    Institute of Experimental Dermatology, University of Muenster, Roentgenstr 21, 48149 Muenster, Germany
    J Mol Biol 359:961-72. 2006
    ..The heterodimers of S100A8 and S100A9 represent the major calcium-binding proteins in phagocytes...
  12. ncbi Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues
    M M Wilkinson
    Department of Medicine, Western General Hospital, Edinburgh, UK
    J Cell Sci 91:221-30. 1988
    ..Monoclonal antibodies, specifically recognizing the tentatively named cystic fibrosis antigen (CFAg), were produced...
  13. ncbi Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
    K Odink
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Nature 330:80-2. 1987
    ..Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation...
  14. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
  15. ncbi MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner
    J Roth
    Institute of Experimental Dermatology, University of Munster, Germany
    Blood 82:1875-83. 1993
    b>MRP8 and MRP14 are two Ca(2+)-binding proteins of the S-100 family expressed by myelomonocytic cells. Both proteins assemble to noncovalently associated complexes in a Ca(2+)-dependent manner...
  16. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
  17. ncbi Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
    C Kerkhoff
    Institut für Experimentelle Dermatologie, Munster, Germany
    Biochim Biophys Acta 1448:200-11. 1998
    The two migration inhibitory factor- (MIF)-related protein-8 (MRP8; S100A8) and MRP14 (S100A9) are two calcium-binding proteins of the S100 family...
  18. ncbi Interaction of S100A8/S100A9-arachidonic acid complexes with the scavenger receptor CD36 may facilitate fatty acid uptake by endothelial cells
    C Kerkhoff
    Institute of Experimental Dermatology, D 48149 Munster, Germany
    Biochemistry 40:241-8. 2001
    Recently, we showed that S100A8/A9 were secreted from phorbol ester-stimulated neutrophil-like HL-60 cells, thereby carrying arachidonic acid [Kerkhoff et al. (1999) J. Biol. Chem. 274, 32672-32679]...
  19. pmc Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity
    Satoru Yui
    Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui gun, Kanagawa, Japan
    Mediators Inflamm 11:165-72. 2002
    ..is composed of 8 and 14 kDa subunits, which have also been termed migration inhibitory factor-related proteins MRP8 and MRP14...
  20. ncbi Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules
    Johannes Roth
    Institute of Experimental Dermatology, University of Muenster, Von Esmarch Str 58, D 48149 Muenster, Germany
    Trends Immunol 24:155-8. 2003
    ..A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of ..
  21. pmc S100 protein subcellular localization during epidermal differentiation and psoriasis
    Ann Marie Broome
    Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Histochem Cytochem 51:675-85. 2003
    ..Our present studies compare the level of expression, and cellular localization of S100A7, S100A8, S100A9, S100A10, and S100A11 in normal and psoriatic epidermis...
  22. ncbi Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis
    Michael Frosch
    Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
    Arthritis Rheum 48:2622-6. 2003
    ....
  23. ncbi MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
    Thomas Vogl
    Institute of Experimental Dermatology, Department of Pediatrics, University of Munster, Röntgenstrasse 21, D 48149 Munster, Germany
    Blood 104:4260-8. 2004
    ..MRP14, in complex with its binding partner MRP8 (S100A8), promotes polymerization of microtubules...
  24. ncbi Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
    Dorothee Viemann
    Institute of Experimental Dermatology, Integrated Functional Genomics, and the Interdisciplinary Clinical Research Center, University Hospital Muenster, University of Muenster, Röntgenstrasse 21, 48149 Muenster, Germany
    Blood 105:2955-62. 2005
    Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown...
  25. ncbi The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2
    Claus Kerkhoff
    Institute of Experimental Dermatology, University of Munster, Germany
    FASEB J 19:467-9. 2005
    The Ca2+- and arachidonic acid-binding S100A8/A9 protein complex was recently identified by in vitro studies as a novel partner of the phagocyte NADPH oxidase...
  26. ncbi S100A8 and S100A9 in human arterial wall. Implications for atherogenesis
    Michelle M McCormick
    School of Medical Sciences, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    J Biol Chem 280:41521-9. 2005
    Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate immunity and regulate processes leading to leukocyte adhesion and transmigration...
  27. ncbi S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 312:184-97. 2006
    ..Deregulated expression of S100 proteins, including S100A8 and S100A9, was reported in association with neoplastic disorders...
  28. pmc The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
    Katsue Sunahori
    Department of Medicine and Clinical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arthritis Res Ther 8:R69. 2006
    b>S100A8 and S100A9, two Ca2+-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages...
  29. ncbi Expression of myeloid-related protein-8 and -14 in patients with acute Kawasaki disease
    Keiich Hirono
    Department of Pediatrics, Toyama University, Toyama, Japan
    J Am Coll Cardiol 48:1257-64. 2006
    ..This study investigated patients with acute Kawasaki disease (KD) to validate myeloid-related protein (MRP)-8/MRP-14 as a marker of disease activity and severity of coronary artery lesion development...
  30. ncbi Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations
    Thomas Vogl
    Institute of Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
    Biochim Biophys Acta 1763:1298-306. 2006
    b>S100A8 and S100A9 are two proinflammatory molecules belonging to the S100 family of calcium-binding proteins...
  31. ncbi HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities
    Malgorzata Benedyk
    Institute of Experimental Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 127:2001-11. 2007
    The calcium- and arachidonic acid (AA)-binding proteins S100A8 and S100A9 are involved in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in phagocytes...
  32. ncbi S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity
    Tor Magne Madland
    Section for Rheumatology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Rheumatol 34:2089-92. 2007
    To investigate serum levels of calprotectin (S100A8/S100A9) and S100A12 as markers of disease activity or distinct clinical or radiographic features in patients with psoriatic arthritis (PsA).
  33. ncbi Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease
    Steven T Leach
    School of Women s and Children s Health, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Scand J Gastroenterol 42:1321-31. 2007
    ..The objective of this study was to assess serum and mucosal levels of calprotectin, S100A12 and soluble receptor for advanced glycation end products (sRAGE), a putative S100 ligand, in a paediatric population with IBD...
  34. ncbi S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2
    Saeid Ghavami
    Manitoba Institute of Cell Biology, Canada
    Biochim Biophys Acta 1783:297-311. 2008
    A complex of two S100 EF-hand calcium-binding proteins S100A8/A9 induces apoptosis in various cells, especially tumor cells...
  35. pmc S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
    Saeid Ghavami
    Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
    J Leukoc Biol 83:1484-92. 2008
    The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosis-inducing activity against various cells, especially tumor cells...
  36. ncbi S100A8 and S100A9 overexpression is associated with poor pathological parameters in invasive ductal carcinoma of the breast
    Kazumori Arai
    Department of Pathology, Shizuoka General Hospital, 4 27 1 Kitaando, Aoi ku, Shizuoka 420 0881, Japan
    Curr Cancer Drug Targets 8:243-52. 2008
    ..monoclonal antibodies, and the results were as follows: 1) A positive correlation of immunoreactivity between S100A8 and S100A9 was noticed (r=0.873 and P<0...
  37. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..Carboxylated glycans are expressed on a subpopulation of RAGE on colon cancer cells and mediate S100A8/A9 binding to RAGE...
  38. ncbi S-nitrosylated S100A8: novel anti-inflammatory properties
    Su Yin Lim
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Immunol 181:5627-36. 2008
    b>S100A8 and S100A9, highly expressed by neutrophils, activated macrophages, and microvascular endothelial cells, are secreted during inflammatory processes...
  39. doi Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasion
    Aree Moon
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Mol Cancer Res 6:1544-53. 2008
    ..We then tested whether S100A8 and S100A9, two of the genes which are most highly up-regulated in an H-Ras-specific manner, play a causative role ..
  40. pmc Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation
    Herve Y Sroussi
    Department of Oral Medicine and Diagnostic Sciences, UIC College of Dentistry M C 838, University of Illinois, Chicago, IL 60612 7213, USA
    FEMS Immunol Med Microbiol 55:55-61. 2009
    b>S100A8 and S100A9 and their heterocomplex calprotectin (S100A8/A9) are abundant cytosolic constituents in human neutrophils previously shown to possess antifungal activity...
  41. doi IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA
    Yasumi Endoh
    Centre for Infection and Inflammation Research, School of Medical Sciences, University New South Wales, Sydney, Australia
    J Immunol 182:2258-68. 2009
    The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections...
  42. pmc Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
    Klaus Burkhardt
    Nephrological Clinic Weissenburg, 91781 Weissenburg, Germany
    Cardiovasc Diabetol 8:10. 2009
    ..We investigated whether myeloid-related protein 8/14 complex (MRP8/14) secreted by transmigrating monocytes and granulocytes may represent a biomarker for microvascular alterations ..
  43. doi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  44. pmc Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate
    Kiran Yanamandra
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS ONE 4:e5562. 2009
    ..We report here that amyloid formation is linked to another major age-related phenomenon--prostate tissue remodelling in middle-aged and elderly men...
  45. doi S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis
    Julia Nemeth
    Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    Hepatology 50:1251-62. 2009
    ..carcinoma (HCC) revealed a comprehensive list of known and novel putative NF-kappaB target genes, including S100a8 and S100a9...
  46. doi Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus
    Muhammad S Soyfoo
    Department of Rheumatology, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070, Bruxelles, Belgium
    J Rheumatol 36:2190-4. 2009
    b>S100A8 and S100A9 are calcium binding proteins of the S100 family highly expressed in neutrophils and monocytes. S100 proteins are novel ligands of TLR4 important in modulating inflammation...
  47. pmc S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3
    Saeid Ghavami
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, CancerCare Manitoba, Winnipeg, Canada
    Cell Res 20:314-31. 2010
    The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosis-inducing activity in various cells of different origins...
  48. doi S100A8/A9 induces apoptosis and inhibits metastasis of CasKi human cervical cancer cells
    Fengjin Qin
    Gynaecology and Obstetrics Department, Peking University Third Hospital, Beijing, People s Republic of China
    Pathol Oncol Res 16:353-60. 2010
    ..Deregulated expression of S100 proteins, including S100A9 and its partner S100A8, was reported to be associated with neoplastic disorders...
  49. doi Expression of S100A8 in leukemic cells predicts poor survival in de novo AML patients
    E Nicolas
    Department of Clinical Onco Hematology and University Joseph Fourier, Grenoble, France
    Leukemia 25:57-65. 2011
    ..The 10,800-Da marker was identified by MS peptide sequencing as S100A8 (also designated MRP8 or calgranulin A)...
  50. doi RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1
    K Eggers
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Exp Clin Endocrinol Diabetes 119:353-7. 2011
    ..Since S100A8/A9 was recently identified as ligand of RAGE, we determined the effects of proinflammatory cytokines on RAGE-..
  51. pmc Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis
    Lucie Andrés Cerezo
    Institute of Rheumatology, First Medical Faculty, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic
    Arthritis Res Ther 13:R122. 2011
    ..The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA)...
  52. pmc S100A8 and S100A9: new insights into their roles in malignancy
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Innate Immun 4:31-40. 2012
    ..In this regard, damage-associated molecular pattern (DAMP) molecules such as S100A8 and S100A9, with well-known functions in inflammation, have been increasingly recognized not only as markers, but ..
  53. doi S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy
    Liangchun Yang
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Int J Mol Med 29:65-72. 2012
    ..Here we showed that the member of the S100 calcium-binding protein family, S100A8, is a critical regulator of chemoresistance in the autophagy process...
  54. doi Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4
    Rik F P Schelbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1477-87. 2012
    b>S100A8 and S100A9 are two Ca(2+) binding proteins classified as damage-associated molecular patterns or alarmins that are found in high amounts in the synovial fluid of osteoarthritis (OA) patients...
  55. doi Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia
    J A P Spijkers-Hagelstein
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Zuid Holland, The Netherlands
    Leukemia 26:1255-65. 2012
    ..Here, we demonstrate that in MLL-rearranged infant ALL, over-expression of S100A8 and S100A9 is associated with failure to induce free-cytosolic Ca(2+) and prednisolone resistance...
  56. pmc Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway
    Mizhir Atallah
    The Laboratory for Cellular and Molecular Immunology, Department of Medicine, Hadassah Hebrew University Medical Center Jerusalem, Jerusalem, Israel
    PLoS ONE 7:e29333. 2012
    ..This mechanism is suggested to have a fine-tuning role in regulating the neutrophil number in bone marrow, peripheral blood, and inflammatory sites...
  57. doi A role for MRP8 in in stent restenosis in diabetes
    A Stocca
    Regenerative Medicine Institute, REMEDI, National University of Ireland Galway, Ireland
    Atherosclerosis 221:325-32. 2012
    ..We investigated the pathogenesis of in stent restenosis in an animal model of type 2 diabetes mellitus...
  58. pmc Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes
    Thomas Vogl
    Institute of Immunology, University of Muenster, Röntgenstr 21, 48149 Muenster, Germany e mail
    Int J Mol Sci 13:2893-917. 2012
    b>S100A8 and S100A9 are EF-hand Ca(2+) binding proteins belonging to the S100 family...
  59. pmc Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis
    Ruth J Pepper
    UCL Centre for Nephrology, Royal Free Hospital, London, UK
    Kidney Int 83:1150-8. 2013
    ..The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in ..
  60. pmc S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway
    Liang Duan
    Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China
    PLoS ONE 8:e62092. 2013
    b>S100A8 and S100A9, two members of the S100 protein family, have been reported in association with the tumor cell differentiation and tumor progression...
  61. doi RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial-mesenchymal transition
    Chonggao Yin
    College of Nursing, Weifang Medical University, Weifang, 261053, China
    Breast Cancer Res Treat 142:297-309. 2013
    b>S100A8/A9 proteins are members of EF-hand calcium-binding proteins secreted by neutrophils and activated monocytes...
  62. pmc Potential prognostic biomarkers of pancreatic cancer
    Kathryn T Chen
    From the Department of Surgical Oncology, Developmental Therapeutics, and Departments of Biostatistics, Pathology, and Gastroenterology, Fox Chase Cancer Center, Philadelphia, PA
    Pancreas 43:22-7. 2014
    ..We evaluated whether pancreatic main duct fluid can provide protein biomarkers with prognostic value...
  63. pmc Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation
    E Lagasse
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Mol Cell Biol 8:2402-10. 1988
    ..Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in normal tissue ..
  64. ncbi A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene
    J R Dorin
    Nature 326:614-7. 1987
    ..Abnormal accumulation of such a protein in CF is a clue which must be pursued now that evidence is gathering that the basic defect in CF is in pathways controlling chloride channel activity...
  65. ncbi Analysis of the MRP8-MRP14 protein-protein interaction by the two-hybrid system suggests a prominent role of the C-terminal domain of S100 proteins in dimer formation
    C Propper
    Institute of Experimental Dermatology, Münster Medical School, Von Esmarch Strasse 56, D 48149 Munster, Germany
    J Biol Chem 274:183-8. 1999
    ..Using the two-hybrid system we analyzed the dimerization of MRP8 (S100A8) and MRP14 (S100A9), two S100 proteins expressed in myeloid cells...
  66. ncbi The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution
    K Ishikawa
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    Acta Crystallogr D Biol Crystallogr 56:559-66. 2000
    The structure of human MRP8 in the calcium-bound form was determined at 1.9 A resolution by X-ray crystallography...
  67. ncbi Transendothelial migration of 27E10+ human monocytes
    I Eue
    Institute of Experimental Dermatology, University of Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
    Int Immunol 12:1593-604. 2000
    The myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), two members of the S100 family of calcium-binding proteins, are co-expressed and form a cell-surface and cytoskeleton-associated heterodimer upon calcium mobilization which is ..
  68. ncbi Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism
    Barry Sampson
    Department of Clinical Chemistry, Charing Cross Hospital, W6 8RF, London, UK
    Lancet 360:1742-5. 2002
    Calprotectin (complex of S100A8 and S100A9) is the major calcium and zinc-binding protein of phagocytes...
  69. ncbi Evidence for the involvement of the unique C-tail of S100A9 in the binding of arachidonic acid to the heterocomplex S100A8/A9
    Claudia Sopalla
    Institute of Experimental Dermatology, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    Biol Chem 383:1895-905. 2002
    Protein complexes formed by S100A8 and S100A9 represent the only AA-binding capacity in the human neutrophilic cytosol and are involved in the intracellular arachidonic acid metabolism...
  70. ncbi S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity
    Wolfgang Nacken
    Institute of Experimental Dermatology, University of Munster, 48149 Munster, Germany
    Microsc Res Tech 60:569-80. 2003
    ..Two S100 proteins, namely S100A9 (MRP14) and S100A8 (MRP8), constitute roughly 40% of the cytosolic protein in these cells, implying by their pure abundance an ..
  71. pmc Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation
    Jian Ping Kong
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 10:1093-7. 2004
    ..proteins(MRP)8 and myeloid-related proteins(MRP)14 in human esophageal squamous cell carcinoma and to investigate if there was any correlation between MRP8 and MRP14 expression level and histopathological grade in these tumors.
  72. pmc Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    Philipp Ehlermann
    Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
    Cardiovasc Diabetol 5:6. 2006
    ..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression.
  73. doi iPLA2, a novel determinant in Ca2+- and phosphorylation-dependent S100A8/A9 regulated NOX2 activity
    Véronique Schenten
    Life Sciences Research Unit, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg
    Biochim Biophys Acta 1803:840-7. 2010
    ..a pathway leading to NOX2 activation in which iPLA(2)-regulated p38 MAPK activity is a key regulator of S100A8/A9 translocation via S100A9 phosphorylation...
  74. doi Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
    Andreas Voss
    Institute of Immunology, University of Muenster, Muenster, Germany
    FEBS Lett 585:440-6. 2011
    b>S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation...
  75. pmc Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus
    Christian Lood
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Solvegatan 23, 223 62 Lund, Sweden
    Arthritis Res Ther 13:R60. 2011
    ..The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a ..
  76. ncbi Changing the conformation state of cytochrome b558 initiates NADPH oxidase activation: MRP8/MRP14 regulation
    Sylvie Berthier
    Groupe de Recherche et d Etude du Processus Inflammatoire, Laboratoire d Enzymologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble, France
    J Biol Chem 278:25499-508. 2003
    Phagocyte NADPH oxidase generates O2. for defense mechanisms and cellular signaling. Myeloid-related proteins MRP8 and MRP14 of the S100 family are EF-hand calcium-binding proteins...
  77. ncbi The hetero-oligomeric complex of the S100A8/S100A9 protein is extremely protease resistant
    Wolfgang Nacken
    Institute for Experimental Dermatology, University of Muenster, Roentgenstrasse 21, 48149 Muenster, Germany
    FEBS Lett 581:5127-30. 2007
    b>S100A8, S100A9 and S100A12 proteins are associated with inflammation and tissue remodelling, both processes known to be associated with high protease activity...
  78. pmc S100A8 and S100A9 in experimental osteoarthritis
    Hala Zreiqat
    Tissue Engineering and Biomaterials Research Unit, School of AMME J07, Faculty of Engineering, Bosch Institute, University of Sydney, Corner of Shepherd and Cleavland Street, New South Wales 2006, Australia
    Arthritis Res Ther 12:R16. 2010
    The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.
  79. ncbi The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils
    Jacques Doussiere
    Laboratoire de Biochimie et Biophysique des Systèmes Intégrés UMR 5092 CEA CNRS UJF, Departement Reponse et Dynamique Cellulaires, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Eur J Biochem 269:3246-55. 2002
    In a previous study, the S100A8/A9 protein, a Ca2+- and arachidonic acid-binding protein, abundant in neutrophil cytosol, was found to potentiate the activation of the redox component of the O2- generating oxidase in neutrophils, namely ..
  80. doi Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells
    Chin Wee Ang
    The Liverpool Cancer Research UK Centre, Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool L69 3GA, UK
    Carcinogenesis 31:1541-51. 2010
    b>S100A8 and its dimerization partner S100A9 are emerging as important chemokines in cancer. We previously reported that Smad4-negative pancreatic tumors contain fewer stromal S100A8-positive monocytes than their Smad4-positive counterparts...
  81. ncbi Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 100:627-34. 2000
    ..Previously, in human focal cerebral infarctions an early expression of macrophage-related protein-8 (MRP8/ S100A8), a member of the Ca2+-binding S100-protein family, in microglia has been reported...
  82. ncbi Immunopathogenic mechanisms in hypertension
    N Lefkos
    Cardiology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Am J Hypertens 8:1141-5. 1995
    ..immunity against arterial wall antigen was studied in all subjects by means of migration inhibitory factor (MIF) against relevant antigen preparation...
  83. ncbi [Detection of anti-Chlamydia trachomatis antibody by means of enzyme immunoassay using synthetic peptide antigen]
    H Bannai
    Dept. of Medical Technology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 73:633-9. 1999
    ..Ltd., Tokyo; for IgG and IgA), were evaluated using the microimmunofluorescence assay (MIF) as the gold standard. These results were also compared to results of testing by Sero-IPALISA and immunoblot (I-B)...
  84. ncbi Side effects of antibiotics on immune response parameters and their possible implications in antimicrobial chemotherapy
    G Gillissen
    Institute of Medical Microbiology, Medical Faculty, , Aachen
    Zentralbl Bakteriol Mikrobiol Hyg A 270:171-99. 1988
    ..g. foodpad swelling reaction, MIF-production, mitogen/antigen induced lymphocyte proliferation and delayed type hypersensitivity skin reaction), on ..
  85. ncbi Histological and clinical predictive value of determination of tissue CagA status by PCR in Helicobacter pylori infected patients; results of the large population based study in western Turkey
    Murat Saruc
    Department of Gastroenterology, Celal Bayar University, Manisa, Turkey
    Hepatogastroenterology 49:878-81. 2002
    Early experimental and epidemiological studies have suggested that the presence of cagA gene was a virulence factor for Helicobacter pylori...
  86. ncbi Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophages
    W Sakamoto
    Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
    Biofactors 10:139-43. 1999
    Macrophage migration inhibitory factor (MIF), a putative cytokine involved in inflammatory and immune responses, was identified in rat peritoneal macrophages by Western blot analysis and its secretion into culture medium by enzyme-linked ..
  87. ncbi S100A8, S100A9, and the S100A8/A9 complex in circulating blood are not associated with prostate cancer risk-A re-evaluation study
    Stefan Ludwig
    Department of Urology, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Prostate 67:1301-7. 2007
    To evaluate the diagnostic performance of plasma S100A8, S100A9, and the S100A8/A9 complex as novel markers to discriminate between benign and malignant prostatic diseases as recently suggested for S100A9.
  88. ncbi [Relationship between Helicobacter pylori infection and expression of connexin (Cx) 32 and Cx43 genes in gastric cancer and gastric precancerous lesions]
    Can xia Xu
    Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Zhonghua Yi Xue Za Zhi 88:1523-7. 2008
    ..To investigate the expression of connexin (Cx)32 and Cx43 genes in gastric cancer and precancerous lesion, and to investigate the relation between the changes of expression of Cx32 and Cx43 genes and Helicobacter pylori (Hp) infection...
  89. ncbi [Studies on transference of hydrogenase genes of Rhizobium arachis]
    Z Wang
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Wei Sheng Wu Xue Bao 41:421-6. 2001
    The hydrogen-uptake genes were transferred into wild Rhizobium arachis Ra strains (Hup-, Nif+, Apr) by triparental mating using pRK2013 as help plasmid. A transconjugant R...
  90. ncbi [Effect of CagA(+) helicobacter pylori strain on the expression of connexin 43 and cell proliferation in BGC-823 cells]
    Can xia Xu
    Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:288-94. 2007
    To determine the effect of CagA(+) Helicobacter pylori(H.pylori)strain and anti-H...
  91. ncbi The two calcium-binding proteins, S100A8 and S100A9, are involved in the metabolism of arachidonic acid in human neutrophils
    C Kerkhoff
    Institut für Experimentelle Dermatologie, 48149 Munster, Germany
    J Biol Chem 274:32672-9. 1999
    Recently, we identified the two myeloid related protein-8 (MRP8) (S100A8) and MRP14 (S100A9) as fatty acid-binding proteins (Klempt, M., Melkonyan, H., Nacken, W., Wiesmann, D., Holtkemper, U., and Sorg, C. (1997) FEBS Lett. 408, 81-84)...
  92. ncbi [A case of fulminant psittacosis necessitating mechanical ventilation diagnosed by chlamydial isolation form BALF]
    H Taniguchi
    Third Department of Internal Medicine, Miyazaki Medical College, Japan
    Kansenshogaku Zasshi 69:1396-401. 1995
    ..diagnosis was established with a significant rise of both IgG and IgM antibody against Chlamydia psittaci with MIF and identification of Chlamydia with the cell culture method...
  93. ncbi Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    Tadamichi Shimizu
    Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 279:13729-37. 2004
    Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
  94. ncbi [Spontaneous cure of pneumonia caused by Chlamydia pneumoniae]
    N Miyashita
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 69:934-9. 1995
    ..512-fold in the acute phase and decreased to 32-fold in the convalescent phase using the micro-immunofluorescence (MIF) test, indicating a C. pneumoniae acute infection. In fact, no other micro-organisms were detected...
  95. pmc Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev Ringvej, DK 2730 Herlev, Denmark
    Crit Care 13:R101. 2009
    Macrophage migration inhibitory factor (MIF) plays an essential pathophysiological role in septic shock, but its role in central nervous system infection (CNS) remains to be defined.
  96. ncbi [A child with iritis due to Chlamydia pneumoniae infection]
    S Yamada
    Department of Pediatrics, Kurume University School of Medicine
    Kansenshogaku Zasshi 68:1543-7. 1994
    ..pneumoniae infection was made by specific polymerase chain reaction (PCR) method and microimmunofluorescence test (MIF). The symptoms subsided with administration of clarithromycin (CAM: 300 mg/day) for 2 weeks...
  97. ncbi CagA status and Helicobacter pylori eradication among dyspeptic patients
    A F Novaes de Magalhães
    Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil
    Gastroenterol Hepatol 28:441-4. 2005
    ..It has been suggested that this difference depends on the expression of CagA protein that is more frequent in the former...
  98. ncbi A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment
    A Meinhardt
    Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    J Cell Sci 112:1337-44. 1999
    Macrophage migration inhibitory factor (MIF), one of the first cytokines to be discovered, has recently been localized to the Leydig cells in adult rat testes...
  99. ncbi The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis
    Mai Tuyet Nguyen
    Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart and Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany
    J Immunol 170:3337-47. 2003
    The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis...
  100. ncbi Interferon-tau stimulates secretion of macrophage migration inhibitory factor from bovine endometrial epithelial cells
    Bingtuan Wang
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec J2S 7C6, Canada
    Biol Reprod 69:1690-6. 2003
    ..12-kDa protein contained a partial amino acid sequence that corresponded to macrophage migration inhibitory factor (MIF)...
  101. ncbi [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats]
    Fu Zhou Wang
    Department of Anesthesia, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China
    Zhonghua Yi Xue Za Zhi 87:768-73. 2007
    To investigate the role of macrophage migration inhibitory factor (MIF) in septic shock-induced cardiovascular dysfunction.

Research Grants67

  1. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2003
    ..The decreasing prevalence of cagA+ Helicobacter pylori may be associated with the rising incidence of esophageal adenocarinomas in industrialized ..
  2. Potential Role of H. Pylori-induced MIF in Gastric Cancer
    ELLEN BESWICK; Fiscal Year: 2009
    ..H. pylori induces macrophage migration inhibitory factor (MIF) production from gastric epithelial cells, and MIF production is an important factor in many cancers...
  3. Richard M Peek; Fiscal Year: 2016
    ..and several cag genes encode components of a type IV secretion system which exports bacterial proteins such as CagA into host epithelial cells. Our group has now demonstrated that H...
  4. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..gastric proton pump (H,K-ATPase) 1 subunit (HK1) gene expression by interactions of cag PAI virulence factors CagL, CagA and peptidoglycan with parietal cells via the TFSS, perturbing signaling pathways essential to acid secretion...
  5. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
    ..Individuals infected with strains that carry the functional form of the cytotoxin-associated gene A, cagA, have an increased risk of developing gastric cancer...
  6. ANNE MUESCH; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Par1-substrates responsible for CagA-mediated pathogenesis of Helicobacter pylori Gastritis and gastric carcinoma, the second leading cause of cancer-related deaths in the world, have been linked to ..
  7. Douglas Morgan; Fiscal Year: 2014
    ..A host of strai specific genetic factors affect gastric cancer risk, such as the cagA and vacAs1m1 genotypes...
  8. Analysis of the H. Pylori cag pathogenicity island
    Timothy L Cover; Fiscal Year: 2012
    ..The cag PAI encodes an effector protein, CagA, and multiple proteins that translocate CagA into gastric epithelial cells via a type IV secretion process...
  9. Lin Feng Chen; Fiscal Year: 2014
    ..H. pylori virulence factor CagA is injected into epithelial cells via the type 4 secretion system and has long been indicated to be critical for ..
  10. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..response to stress, we will identify additional genes involved in expression of the iron- regulated virulence genes cagA and vacA using reporter constructs and a near-saturating transposon library...
  11. Regulatory Mechanisms of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2013
    ..subsequent studies suggest that the effect on disease may be due to a role for Fur in activation of expression of cagA, which encodes a type IV secreted effector protein that is crucial for cancer development...
  12. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..pylori maintains DC toleragenic phenotype. 1.1. To study the role of H. pylori factors (PAI, CagA, VacA) in the maintenance of DC tolerance using knockout strains of H. pylori...
  13. Meira Epplein; Fiscal Year: 2016
    ..pylori proteins (Omp, HP0305, HyuA, HpaA, CagA, and VacA) may be a novel biomarker panel for gastric cancer risk...
  14. Meira Epplein; Fiscal Year: 2015
    ..1-4 And, while the proteins CagA and VacA that are found in some strains of H...
  15. Metal-dependent regulation of the H. pylori Cag type IV secretion system
    Jennifer A Gaddy; Fiscal Year: 2012
    ..cag PAI), which encodes a type IV secretion system (T4SS) responsible for the delivery of the oncogenic protein CagA into gastric epithelial cells...
  16. Jennifer A Gaddy; Fiscal Year: 2016
    ..cag-PAI), which encodes a type IV secretion system (T4SS) responsible for the delivery of the oncogenic protein CagA into gastric epithelial cells...
  17. Richard M Peek; Fiscal Year: 2016
    ..that augments cancer risk is the cag type IV secretion system (TFSS), which translocates the microbial effector CagA into epithelial cells. A host molecule that influences cancer in conjunction with H. pylori is p120-catenin (p120)...
  18. Karen M Ottemann; Fiscal Year: 2014
    ..apparatus, the cag PAI, and is required for sustained phosphorylation of the proinflammatory protein CagA. The specific objective of this work is to determine the molecular basis for ImaA's effect on inflammation, ..
  19. Interactions of Helicobacter pylori CagA with Host Factors
    CHARLES EREC STEBBINS; Fiscal Year: 2013
    ..The bacterium has been listed as a Group 1 carcinogen by the World Health Organization. The CagA cytotoxin of H...
  20. Inactivation of RUNX3 by Helicobacter pylori and gastric cancer
    Lin Feng Chen; Fiscal Year: 2013
    ..RUNX3 by inducing its ubiquitination and degradation during an early stage of the infection in a virulence factor CagA-dependent manner...
  21. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
  22. Laura E Nagy; Fiscal Year: 2016
    ..a pre- clinical mouse model of chronic ethanol exposure, we have identified macrophage migration inhibitory factor (MIF) as an important contributor to ethanol-induced steatosis and inflammation...
  23. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..paradigm for AMPK activation, based on our discovery that the cytokine macrophage migration inhibitory factor (MIF) has an autocrine/paracrine effect to amplify AMPK activation during ischemia...
  24. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
  25. Rituparna Das; Fiscal Year: 2014
    ..My preliminary data demonstrate an important role for macrophage migration inhibitory factor (MIF), a cytokine and upstream mediator of the innate immune response, in pneumococcal infection...
  26. Arthur A Vandenbark; Fiscal Year: 2016
    ..on the monocyte cell surface and blocking the inflammatory effects of macrophage migration inhibitory factor (MIF) that is a key pathogenic cytokine for EAE and MS...
  27. Regulation of Hypoxic Pulmonary Hypertension by MIF
    Todd M Kolb; Fiscal Year: 2012
    ..The pluripotential cytokine MIF (macrophage migration inhibitory factor) has described roles in regulating changes in cardiomyocyte glucose ..
  28. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    Colin Sumners; Fiscal Year: 2013
    ..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive rat neurons...
  29. Edmund J Miller; Fiscal Year: 2016
    ..clinically relevant interaction between a proinflammatory cytokine [Macrophage Migration Inhibitory Factor (MIF)] and a thyroid hormone [Thyroxine (T4)] in PAH...
  30. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
    ..inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
  31. Safe and Efficacious Oral MIF Inhibitors for Rheumatoid Arthritis Treatment
    ANDERSON GAWECO; Fiscal Year: 2012
    ..Selective inhibition of macrophage migration inhibitory factor [MIF] has been target validated demonstrating unprecedented superior safety and efficacy in preclinical RA and several ..
  32. MEREDITH A GREENE; Fiscal Year: 2016
    ..Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that has been studied for its role in the immune system and in autoimmune diseases ..
  33. Yatrik M Shah; Fiscal Year: 2016
    ..3) The proinflammatory mediators, macrophage migration inhibitory factor (MIF) and prostaglandin E2 (PGE2) are early initiating factors in HIF2a-induced colon inflammation...
  34. CHANGHYON CHRIS YUN; Fiscal Year: 2015
    ..cyclin D, hypoxia-inducible factor (HIF)-1?, HIF-2?, cyclooxygenase-2, and macrophage migration inhibitory factor (MIF)...
  35. Molecular characterization of a hookworm Macrophage Migration Inhibitory Factor
    Jon J Vermeire; Fiscal Year: 2010
    ..We have identified an orthologue of the inflammatory mammalian cytokine macrophage migration inhibitory factor (MIF) from the human hookworm Ancylostoma ceylanicum...
  36. PATRICIA JEAN JOHNSON; Fiscal Year: 2014
    ..vaginalis homologue of the inflammatory cytokine, human macrophage migration inhibitory factor (MIF). Increased level of human MIF (HuMIF) have been found in both prostate cancer and the semen of infertile men...
  37. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
    ..Macrophage migration inhibitory factor (MIF) is a pleiotropi cytokine which is produced by variety of cells, including activated macrophages and neutrophils...
  38. Developing Small MIF Inhibitors for Rheumatoid Arthritis
    Christian Grant; Fiscal Year: 2013
    ..academic partner (The Feinstein Institute for Medical Research), targets macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine whose dysregulation underlies many autoimmune diseases...
  39. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    ..by applicant): The goal of this proposal is to examine the role of macrophage migration inhibitory factor (MIF) in the regulation of osteoclastogenesis...
  40. Colin Sumners; Fiscal Year: 2014
    ..We established previously that in normal rats MIF is an Ang II-inducible intracellular negative regulator of the AT1R mediated excitation of PVN to RVLM sympathetic ..
  41. Pedro L Vera; Fiscal Year: 2016
    ..applicant): Experimental evidence supports the pro-inflammatory effect of Macrophage Migration Inhibitory Factor (MIF) in bladder inflammation, but how MIF mediates bladder inflammation is poorly understood...
  42. Amplification of tumor hypoxic responses by MIF-dependent HIF stabilization
    Robert A Mitchell; Fiscal Year: 2013
    ..We recently discovered that macrophage migration inhibitory factor (MIF), one of the oldest cytokines ever described, is elevated in PDAC patient's plasma and induced by hypoxia-..
  43. Thomas Yoonsang Cho; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Abstract Macrophage migration inhibitory factor (MIF) plays an important role for the recruitment of innate and adaptive immune cells to the place of inflammation...
  44. MIHAELA GUEORGUIEVA GADJEVA; Fiscal Year: 2016
    ..studies conducted during my current R21 funding period which showed that macrophage migration inhibitory factor (MIF) has an unappreciated importance in regulating innate immune responses to P...
  45. Orchestration of breast cancer osteolytic bone metastasis by MIF
    Jessica M Grunda; Fiscal Year: 2013
    ..metastasis generated by our laboratory as a 'discovery tool', macrophage migration inhibitory factor (MIF) was identified as a factor potentially orchestrating the development of breast cancer osteolytic bone metastasis ..
  46. Richard F Loeser; Fiscal Year: 2014
    ..exploratory and developmental (R21) project is to determine the role of macrophage migration inhibitory factor (MIF) in the development of osteoarthritis (OA) in mice and obtain data on MIF function in human joint tissues...
  47. William L Jorgensen; Fiscal Year: 2016
    ..biomolecular targets are addressed: HIV-1 reverse transcriptase (HIV-RT), macrophage migration inhibitory factor (MIF), and tyrosyl-DNA phosphodiesterase 1 (Tdp1)...
  48. Regulators of Endothelial Cell Apoptosis in LPS-Induced Acute Lung Injury
    Rachel L Damico; Fiscal Year: 2012
    ..Further, her work demonstrates that macrophage migration inhibitory factor (MIF) is a determinant of EC responses to LPS...
  49. Lara A Ray; Fiscal Year: 2014
    ..glial cell modulator that inhibits phosphodiesterases (PDE) -4 and -10 and macrophage migration inhibitory factor (MIF)...
  50. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    KAREN G ANTHONY; Fiscal Year: 2013
    ..the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF)...
  51. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, and to play a ..
  52. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
  53. Therapeutic Inhibition of MIF in Rheumatoid Arthritis
    Karen Anthony; Fiscal Year: 2009
    ..RA), which will act by reducing the inflammatory response triggered by macrophage migration inhibitory factor (MIF). RA afflicts up to 4 million people in the U.S...
  54. HEMOZOIN AND MALARIA PATHOGENESIS
    JAMES MARTINEY; Fiscal Year: 1999
    ..We have preliminary data demonstrating the release of large amounts of macrophage migration inhibitory factor (MIF) by macrophages after ingestion of hemozoin or parasitized erythrocytes...
  55. GIF regulation of B cells and CD4 cells
    Katsuji Sugie; Fiscal Year: 2003
    ..the genome and its nucleotide sequence is identical is that published for macrophage migration inhibitory factor (MIF). MIF(GIF)-/- mice show enhanced susceptibility to Leishmania major...
  56. MACROPHAGE PROLIFERATION AND ACTIVATION
    John Hadden; Fiscal Year: 1980
    ..Sephadex chromatography indicates an approximate molecular weight similar to that of migration inhibitory factor (MIF); however, vacuum dialysis prior to chromatography removes MIF and, therefore, distinguishes between the two ..
  57. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..Macrophage migration inhibitory factor (MIF) is an immunohormonal molecule that overrides the effect of cortisol on the GR...
  58. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Macrophage migration inhibitory factor (MIF) is a unique molecule that functions as a cytokine and a hormone, and is induced by infections and psychological stress in animal models...
  59. The role of MIF in hookworm infection and disease
    Michael Cappello; Fiscal Year: 2009
    ..A eDNA corresponding to a homologue of the mammalian cytokine Macrophage Migration Inhibitory Factor (MIF) has recently been cloned from the human hookworm Ancylostoma ceylanicum...
  60. MOLECULES INVOLVED IN MACROPHAGE RESPONSES TO LYMPHOKINE
    David Liu; Fiscal Year: 1990
    ..This proposal is aimed at the dissection of the interaction of one lymphokine, migration inhibitory factor (MIF), with its target cell the macrophage...
  61. Novel MLCK-MIF Interaction in Endothelium
    Ari Zaiman; Fiscal Year: 2002
    ..portion of EC MLCK was found to interact with a proinflammatory cytokine, macrophage migration inhibitory factor (MIF), a regulator of innate and acquired immunity with a pathologic role in ARDS, sepsis, and arthritis...
  62. Migration Inhibitory Factor in the Progression of EAE
    Caroline C Whitacre; Fiscal Year: 2010
    ..Migration inhibitory factor (MIF) has recently been re-discovered as an inducer of pro- inflammatory cytokines and an antagonist of glucocorticoid ..
  63. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ..CD74 has been identified as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF is a pro-inflammatory protein that is secreted by cells upon exposure to microbes or their products...
  64. Role of MIF in Rb inactivation and Tumorigenesis
    Robert Mitchell; Fiscal Year: 2009
    ..We recently discovered that the pro-inflammatory cytokine, migration inhibitory factor (MIF) is both necessary and sufficient for mitogen and oncogene-induced cyclin D1 transcription, Cdk4 activity and Rb ..
  65. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..Calcium-binding heterodimeric proteins S100A8 and S100A9 are pro-inflammatory mediators that are also highly expressed in many tumors...
  66. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..CNS are involved in morphine tolerance-dependence and abstinence processes and (c) peptides like Pro-Leu-Gly-NH2 (MIF) and cyclo(Leu-Gly) (CLG) inhibit morphine tolerance-dependence and abstinence processes by affecting DA and opiate ..
  67. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..inhibitor SPINK5 and molecules in the epidermal differentiation complex (EDC), including S100A7 (psoriasin), S100A8 and S100A9 (calgranulins A and B)...

Patents1

  1. Novel lymphokine related peptides
    Patent Number: EP0263072-A2; Date:1988-04-06