S100A6

Summary

Gene Symbol: S100A6
Description: S100 calcium binding protein A6
Alias: 2A9, 5B10, CABP, CACY, PRA, protein S100-A6, MLN 4, calcyclin, growth factor-inducible protein 2A9, prolactin receptor-associated protein
Species: human

Top Publications

  1. ncbi S100A6 (calcyclin) enhances the sensitivity to apoptosis via the upregulation of caspase-3 activity in Hep3B cells
    Joung Hyuck Joo
    Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology KRIBB, P O Box 115, Deajeon 305 333, Republic of Korea
    J Cell Biochem 103:1183-97. 2008
  2. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
  3. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
  4. ncbi Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro
    Ellen C Breen
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    J Cell Biochem 88:848-54. 2003
  5. ncbi Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 278:20210-6. 2003
  6. ncbi Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins
    Marcin Nowotny
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 278:26923-8. 2003
  7. ncbi Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display
    Lauge Farnaes
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:33120-6. 2003
  8. ncbi Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Cancer Lett 229:135-48. 2005
  9. ncbi The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:7785-93. 2005
  10. doi Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer
    Luigi De Petris
    Karolinska Biomics Center, Karolinska Intitutet, Stockholm, Sweden
    Lung Cancer 63:410-7. 2009

Research Grants

  1. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
  2. Role of ANG II in Maintaining Vascular Relaxation in Dahl S Rats
    Julian H Lombard; Fiscal Year: 2010
  3. ALDOSTERONE, RENIN AND PROSTAGLANDINS IN MAN
    Richard Horton; Fiscal Year: 1980
  4. RACE, RENIN, GENES, RISK, AND DIABETIC NEPHROPATHY
    NORMAN HOLLENBERG; Fiscal Year: 2002
  5. PETER SCOTT HEEGER; Fiscal Year: 2016
  6. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
  7. Intermountain Pediatric Heart Disease Research Center
    L Luann Minich; Fiscal Year: 2010
  8. S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIES
    Walter Chazin; Fiscal Year: 2009
  9. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
  10. AMERICAN SOCIETY OF HUMAN GENETICS PUBLIC HEALTH GENETICS FELLOWSHIP
    Joann A Boughman; Fiscal Year: 2011

Detail Information

Publications346 found, 100 shown here

  1. ncbi S100A6 (calcyclin) enhances the sensitivity to apoptosis via the upregulation of caspase-3 activity in Hep3B cells
    Joung Hyuck Joo
    Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology KRIBB, P O Box 115, Deajeon 305 333, Republic of Korea
    J Cell Biochem 103:1183-97. 2008
    S100A6 (calcyclin) is a small calcium-binding protein which has been implicated in several cellular processes such as cell cycle progression, cytoskeleton rearrangement, and exocytosis...
  2. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
  3. ncbi The S100 family of EF-hand calcium-binding proteins: functions and pathology
    B W Schafer
    Department of Pediatrics, University of Zurich, Switzerland
    Trends Biochem Sci 21:134-40. 1996
    ..Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging...
  4. ncbi Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro
    Ellen C Breen
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    J Cell Biochem 88:848-54. 2003
    b>Calcyclin (S100A6) is a member of the S100A family of calcium binding proteins...
  5. ncbi Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope
    Alejandra Tomas
    Division of Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 278:20210-6. 2003
    ..is in contrast to its most extensively characterized in vitro ligand, the small calcium-binding protein S100A6 (calcyclin), which is concentrated in the nuclear envelope...
  6. ncbi Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins
    Marcin Nowotny
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 278:26923-8. 2003
    S100A6 (calcyclin), a small calcium-binding protein from the S100 family, interacts with several target proteins in a calcium-regulated manner...
  7. ncbi Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display
    Lauge Farnaes
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:33120-6. 2003
    ..b>Calcyclin, found previously to bind annexin XI in vitro, in vivo coated the nuclear membrane of cultured cell lines and ..
  8. ncbi Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Cancer Lett 229:135-48. 2005
    ..To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6...
  9. ncbi The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:7785-93. 2005
    ..In the present study, to evaluate the involvement of S100A6 in pancreatic cancer and its clinical usefulness for diagnosis, we examined S100A6 mRNA expression in pancreatic ..
  10. doi Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer
    Luigi De Petris
    Karolinska Biomics Center, Karolinska Intitutet, Stockholm, Sweden
    Lung Cancer 63:410-7. 2009
    In a previously published in vitro study based on top-down proteomics we found that the calcium-binding proteins S100A6 and S100A4 were affected by exposure to ionizing radiation in a p53-dependent fashion...
  11. pmc S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
    T Nedjadi
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Br J Cancer 101:1145-54. 2009
    High levels of S100A6 have been associated with poor outcome in pancreatic cancer patients. The functional role of S100A6 is, however, poorly understood.
  12. doi S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    FEBS Lett 584:1119-25. 2010
    ..These findings have suggested that the Ca(2+)/S100 proteins are TPR-targeting regulators of the immunophilins-Hsp90 complex formations...
  13. doi Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma
    Ziqiang Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    J Mol Med (Berl) 92:291-303. 2014
    High levels of S100A6 have been associated with poor outcome in some types of human cancers, but the role of S100A6 in the molecular pathogenesis of these cancers is largely unknown...
  14. ncbi CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family
    Anna Filipek
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    J Biol Chem 277:28848-52. 2002
    Recently, a human ortholog of mouse calcyclin (S100A6)-binding protein (CacyBP) called SIP (Siah-1-interacting protein) was shown to be a component of a novel ubiquitinylation pathway regulating beta-catenin degradation (Matsuzawa, S...
  15. ncbi Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases
    Keiko Komatsu
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Oncology 63:192-200. 2002
    b>S100A6 and S100A4, two of S100 protein family, have been suggested to be associated with cancer tumorigenesis and metastasis...
  16. pmc Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition
    Young Tae Lee
    Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 47:10921-32. 2008
    S100A6 is a member of the S100 subfamily of EF-hand Ca (2+) binding proteins that has been shown to interact with calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP or SIP), a subunit of an SCF-like E3 ubiquitin ligase ..
  17. ncbi Reversal of cardiovascular structural changes when treating essential hypertension. The importance of the renin-angiotensin-aldosterone system
    B Dahlof
    Department of Medicine, University of Goteborg, Ostra Hospital, Sweden
    Am J Hypertens 5:900-11. 1992
    ..blocked the plasma angiotensin converting enzyme (ACE) with a secondary increment in plasma renin activity (PRA) and reductions in angiotensin II (AII) and aldosterone...
  18. ncbi Renal function in one-kidney, one-clip hypertension and low renin essential hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 4:523S-533S. 1991
    ..Another difference is that PRA is low compared to normal PRA in 1-K, 1-C HT after compensatory increases in MAP...
  19. ncbi Effects of the angiotensin converting enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential hypertensive patients
    Y Miyazaki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 11:962-70. 1998
    ..Plasma norepinephrine level (PNE) and plasma renin activity (PRA) showed increases, whereas plasma aldosterone concentration (PAC) did not change with hyperinsulinemia...
  20. ncbi [Effect of a non-antihypertensive dose of ramipril on the plasma and tissue renin-angiotensin system in 27 TGR (mRen2) rats.]
    M Grima
    Institut de Pharmacologie, , , Strasbourg
    Arch Mal Coeur Vaiss 94:805-12. 2001
    ..allows the regression of left ventricular hypertrophy (HVG) in experimental models where plasma renin activity (PRA) is high...
  21. ncbi [Neurohormonal profile in aortic valve stenosis]
    J F Ramirez-Gil
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 86:1001-7. 1993
    ..endothelin 1, atrial natriuretic factor (ANF), arginine vasopressin (AVP), catecholamines, plasma renin activity (PRA), angiotensin II and aldosterone were measured in resting, fasting patients, by blood samplings from a peripheral ..
  22. ncbi Lack of effect of captopril on glomerular hyperfiltration in normoalbuminuric normotensive insulin-dependent diabetic patients
    M J de Azevedo
    Endocrinology Unit, , Universidade Federal do Rio Grande do Sul, RS, Brazil
    Horm Metab Res 29:516-9. 1997
    ..o. twice daily) and after 6 weeks off captopril. Plasma renin activity (PRA; RIA), plasma aldosterone (RIA) and blood volume (51Cr red cell labeled) were measured at baseline and after 6 ..
  23. ncbi Effect of intravenous calcium infusion on indices of activity of the parathyroid glands and on urinary calcium and sodium excretion in normotensive and hypertensive subjects
    N Papagalanis
    Nephrology Department Red Cross General Hospital, Athens, Greece
    Am J Hypertens 6:59-65. 1993
    ..05) and after calcium infusion (P < .001). A positive correlation between basal plasma renin activity (PRA) values and plasma ionized calcium values obtained before (r = 0.42, P = .03) or at 60 min (r = 0.41, P = ...
  24. ncbi Fibrinolytic function in diuretic-induced volume depletion
    K Lottermoser
    , Bonn, Germany
    Am J Hypertens 13:359-63. 2000
    ..Plasma renin activity (PRA) was significantly stimulated during diuretic treatment (1.35 +/- 0.21 v 0.34 +/- 0.06 ng mL(-1) x h(-1) [P < ...
  25. ncbi Renal depressor mechanisms of physical training in patients with essential hypertension
    K Kohno
    Department of Internal Medicine III, Kurume University School of Medicine, Fukuoka, Japan
    Am J Hypertens 10:859-68. 1997
    ..glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA), plasma aldosterone concentration (PAC), plasma norepinephrine concentration (PNE), and incremental area of ..
  26. ncbi Effects of oral calcium, potassium, digoxin, and nifedipine on natriuresis in normal humans
    F C Luft
    Department of Medicine, Indiana University School of Medicine, Indianapolis
    Am J Hypertens 2:14-9. 1989
    ..Sodium balance before infusion was not different among the regimens. Plasma renin activity (PRA) was increased in subjects receiving nifedipine, while the plasma aldosterone concentration (PA) was not different ..
  27. ncbi Intestinal absorption of calcium and calcium metabolism in patients with essential hypertension and normal renal function
    M Gadallah
    Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Am J Hypertens 4:404-9. 1991
    ..When hypertensive patients were stratified according to plasma renin activity (PRA) we found that patients with low PRA had higher intestinal absorption of calcium at 2 h (23 +/- 2.9 v 18 +/- 0...
  28. ncbi Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance
    J R Sowers
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201
    Am J Hypertens 3:16-22. 1990
    ..Plasma levels of factors potentially affecting vascular reactivity (endoxin, renin activity (PRA), and atrial natriuretic peptide (ANP] were measured by RIA and peripheral vascular resistance by biolectrical ..
  29. ncbi [Calcium intestinal absorption in normotensive and essential hypertensive subjects before and after nicardipine]
    B Fouquoire
    , , CHU Lille
    Arch Mal Coeur Vaiss 82:1289-91. 1989
    ..Dosage of calcium and phosphate, Na, K, aldosterone, in blood and urine and PTH and PRA in blood had been effectuated...
  30. ncbi Modification of intracellular calcium and plasma renin by dietary calcium in men
    V Petrov
    Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Belgium
    Am J Hypertens 12:1217-24. 1999
    ..Compared with the placebo group, an increase in the plasma renin activity (PRA) in the calcium group was observed after 4, 8, and 16 weeks of oral calcium administration...
  31. ncbi [Recent advances in the investigation of the renin-angiotensin and cardiac natriuretic systems in patients with chronic heart insufficiency]
    J F Arnal
    INSERM U 36, Paris
    Arch Mal Coeur Vaiss 84:1273-80. 1991
    ..Plasma renin activity (PRA) plasma concentration of active renin, atrial natriuretic hormone and urinary cyclic GMP were higher in patients in ..
  32. ncbi Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable
    S Shigetomi
    , , Canada
    Am J Hypertens 6:33-40. 1993
    ..and their metabolites, as well as plasma atrial natriuretic factor (ANF), cyclic GMP (cGMP), plasma renin activity (PRA), and plasma aldosterone (PA)...
  33. ncbi Atrial natriuretic factor in pregnancy-induced hypertension and preeclampsia: increased plasma concentrations possibly explaining these hypovolemic states with paradoxical hyporeninism
    P Fievet
    , CHU Amiens, France
    Am J Hypertens 1:16-21. 1988
    ..Plasma renin activity (PRA) and plasma aldosterone concentrations were higher in normotensive pregnant women than in normotensive nonpregnant ..
  34. ncbi S100A6 protein expression is different in Spitz nevi and melanomas
    Adriana Ribe
    Dermatopathology Division, Department of Pathology, New York Presbyterian Hospital Cornell University Weill Medical College, New York, New York, USA
    Mod Pathol 16:505-11. 2003
    ..The results showed an up-regulation of S100A6 protein in Spitz nevi, melanomas, and melanocytic nevi but with a different percentage of positivity and pattern ..
  35. ncbi Isradipine in the treatment of hypertension. Some additional effects observed during a one-year study
    O Mayer
    Department of Clinical Pharmacology, University Hospital, Pilsen, Czechoslovakia
    Am J Hypertens 4:140S-143S. 1991
    ..The influence of isradipine on plasma renin activity (PRA) and aldosterone levels was followed by measuring values at rest and during exercise...
  36. ncbi [Activation of the renin-angiotensin system and blood pressure variability in rats]
    J Blanc
    Laboratoire de Pharmacologie, CNRS UMR 8604, , Paris
    Arch Mal Coeur Vaiss 93:1019-22. 2000
    ..The beta-adrenoceptors stimulation by isoprenaline was used to increase the plasma renin activity (PRA). A first group (n = 8) was infused with isoprenaline (0, 0.003, 10, 100, 300 ng/kg/min) at a rate of 20 microL/min...
  37. ncbi [Segmental renal hypoplasia of an adult originating from pseudo-tumor hyperreninism]
    C Goudable
    , CHU de Rangueil, Toulouse
    Arch Mal Coeur Vaiss 81:189-92. 1988
    ..The day after BP was 140/80 mmHg. Eight days after, kaliemia was 4.2 mmol/l, PRA was 0.5 ng/ml/h. Light microscopy showed that affected area was sharply delimited from surrounding normal tissue...
  38. ncbi Acute hemodynamic (systemic and renal) and humoral effects of three increasing doses of iloprost in essential hypertensives
    F Arzilli
    Cattedra di Terapia Medica, Clinica Medica I, University of Pisa, Italy
    Am J Hypertens 2:856-60. 1989
    ..urinary sodium excretion, fractional sodium excretion, noradrenaline, adrenaline, and plasma renin activity (PRA)...
  39. ncbi Effect of reduction of nitric oxide on plasma and kidney tissue angiotensin II levels
    G E Garcia
    Division of Nephrology-Hypertension, Veterans Affairs Medical Center and University of California, San Diego School of Medicine, La Jolla 92161, USA
    Am J Hypertens 10:1103-8. 1997
    ..We measured plasma renin activity (PRA), plasma (AIIp), and kidney tissue (AIIk) AII with radioimmunoassay to investigate the dissociation between renal ..
  40. ncbi Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise
    B D Roy
    Dept. of Kinesiology, University of Waterloo, ON, Canada
    Horm Metab Res 33:238-45. 2001
    ..The prolonged exercise resulted in increases (p<0.05) in plasma vasopressin (AVP), plasma rennin activity (PRA), aldosterone (ALD), atrial naturetic peptide (alpha-ANP), and the catecholamines norepinephrine (NE) and ..
  41. ncbi Central obesity and hypertension. Relationship between fasting serum insulin, plasma renin activity, and diastolic blood pressure in young obese subjects
    G Licata
    Department of Internal Medicine, University of Palermo, Italy
    Am J Hypertens 7:314-20. 1994
    ..of this, plasma catecholamines, fasting serum insulin (IRI), urinary sodium excretion (NaU), plasma renin activity (PRA), and plasma aldosterone (PA) levels were assessed in young (age less than 40 years) normotensive (n = 27) and ..
  42. ncbi Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
    A Finger
    , , Germany
    Eur J Biochem 218:565-74. 1993
    The fate of a mutant form of each of the two yeast vacuolar enzymes proteinase yscA (PrA) and carboxypeptidase yscY (CPY) has been investigated. Both mutant proteins are rapidly degraded after entering the secretory pathway...
  43. ncbi The effects of angiotensin II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension
    M C Smith
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Hypertens 8:1177-83. 1995
    ..to determine the effects of losartan on blood pressure, renal and extrarenal PG production, plasma renin activity (PRA), plasma aldosterone, and routine biochemical parameters...
  44. ncbi Exhaustive exercise-induced tissue hypoxia does not change endothelin and big endothelin plasma levels in normal volunteers
    T Lenz
    Division of Nephrology, Medical Clinic IV, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Am J Hypertens 11:1028-31. 1998
    ..points during, and 5 min after termination of the study for determination of ET-1, Big-ET-1, plasma renin activity (PRA), angiotensin converting enzyme (ACE), norepinephrine, epinephrine, and lactate. Lactate levels at baseline were 14...
  45. ncbi Effect of naloxone on the adrenal cortex in primary aldosteronism
    F Fallo
    Institute of Semeiotica Medica, University of Padova, Italy
    Am J Hypertens 1:280-2. 1988
    ..APA, and IHA, naloxone caused a significant increase in plasma cortisol and no change in ACTH, renin activity (PRA), and aldosterone levels. All subjects were retested after dexamethasone 2 mg...
  46. ncbi Plasma renin activity in the emergency department and its independent association with acute myocardial infarction
    J D Blumenfeld
    The Cardiovascular Center, The Emergency Department, New York Presbyterian Hospital, Weill Medical College, New York 10021, USA
    Am J Hypertens 13:855-63. 2000
    Elevated plasma renin activity (PRA) is associated with increased risk of future myocardial infarction (MI) in ambulatory hypertensive patients...
  47. ncbi Angioplasty of atherosclerotic and fibromuscular renal artery stenosis: time course and predicting factors of the effects on renal function
    F Airoldi
    Istituto di Clinica Medica Generale e Terapia Medica, , Italy
    Am J Hypertens 13:1210-7. 2000
    ..of the stenotic and contralateral kidneys; these measurements were combined with those of plasma renin activity (PRA) and of angiotensin II (AII). We found that in short-term studies after PTRA GFR rose from 29.7 +/- 3.5 to 34...
  48. ncbi Blood pressure responses to sucrose ingestion in four rat strains
    H G Preuss
    Department of Medicine (Nephrology Division, Georgetown University Medical Center, Washington, DC
    Am J Hypertens 5:244-50. 1992
    ..Corresponding with SBP changes, plasma renin activity (PRA), aldosterone, and neuropeptide Y (NPY) concentrations all decreased with the high sucrose-low protein diet ..
  49. ncbi Atrial natriuretic factor in liver cirrhosis--the influence of volume expansion
    V Tesar
    1st Department of Medicine, Faculty of Medicine, Charles University, Prague, Czechoslovakia
    Horm Metab Res 21:519-22. 1989
    ..4 +/- 4.3 fmol/ml). The increase of plasma ANF was accompanied by the suppression of plasma renin activity (PRA) and plasma aldosterone (PA) in all groups; in ascitic patients, however, PRA and PA remained above the normal ..
  50. ncbi Effects of nitrendipine on blood pressure, renin-angiotensin-system and atrial natriuretic peptide in hypertensive type I diabetic patients
    H Lehnert
    III. Medizinische Klinik, , Germany
    Horm Metab Res 25:24-8. 1993
    ..Plasma concentrations of atrial natriuretic peptide (ANP), plasma renin activity (PRA) and active renin, aldosterone, glycosylated hemoglobin (HbA1) and fructosamines were determined at the beginning ..
  51. ncbi Effects of low-dose epinephrine infusion on cardiovascular and renal responses to water immersion in humans
    H J Kruse
    , Bonn, Germany
    Am J Hypertens 9:902-8. 1996
    ..to water immersion without epinephrine were characterized by significant suppression of plasma renin activity (PRA), plasma aldosterone concentration, and renal norepinephrine excretion, and an augmentation of natriuresis and ..
  52. ncbi Plasma renin activity: a risk factor for myocardial infarction in hypertensive patients
    M H Alderman
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Hypertens 10:1-8. 1997
    To determine whether pretreatment plasma renin activity (PRA), without accompanying 24-h urine sodium, can predict myocardial infarction (MI), the PRA levels of 2,902 hypertensive patients [white (38%), male (65%), median age 55 years], ..
  53. ncbi Plasma renin activity and sleep-wake structure of narcoleptic patients and control subjects under continuous bedrest
    H Schulz
    Max Planck Institute for Psychiatry, Munich, Germany
    Sleep 15:423-9. 1992
    ..by a dysfunction of the circadian and ultradian organization of sleep, 24-hour profiles of plasma renin activity (PRA) concomitant with sleep stages were established in 10 normal subjects and nine narcoleptic patients, with 10-minute ..
  54. ncbi Central effects of atrial natriuretic peptide on plasma catecholamines, vasopressin, renin and beta-endorphin and on renal excretory functions in the dog
    E Szeczepańska-Sadowswka
    Department of Clinical and Applied Physiology, Warsaw Academy of Medicine, Poland
    Horm Metab Res 22:323-8. 1990
    ..5 +/- 20.7 to 286.4 +/- 15.0 pg.ml-1 was found at the end of 30 min lasting ANP infusion. Significant elevation of PRA and UKV and a decrease in CH2O were found 60 min after ANP infusion...
  55. ncbi [Increase in plasma levels of active and inactive renin after inhibition of renin activity by SR 42128 in conscious Macaca monkeys]
    J Gougat
    Sanofi Recherche, Montpellier
    Arch Mal Coeur Vaiss 80:875-8. 1987
    Plasma active renin (PAR), plasma inactive renin (PIR), and plasma renin activity (PRA) were determined after intravenous bolus injection of the renin inhibitor SR 42128, in sodium repleted and sodium depleted macacas...
  56. ncbi Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension
    E Grossman
    Chorley Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 7:1041-4. 1994
    ..Trough blood pressure, heart rate, plasma creatinine, potassium, uric acid, cholesterol, renin activity (PRA), aldosterone, and norepinephrine were measured at baseline and after 1 and 12 months of treatment...
  57. ncbi Mechanisms of ozolinone-induced renin release and diuresis
    J E Benabe
    Department of Medicine, Emory University School of Medicine, Atlanta VA Medical Center, Decatur, Georgia
    Am J Hypertens 6:701-7. 1993
    ..Indomethacin (2 mg/kg) markedly blunted the effects of (-)ozo on PG and RSR, and completely abolished the rise in PRA. (+)Ozo had no significant effect on urine PG excretion...
  58. ncbi Ambulatory blood pressure changes in the menstrual cycle of hypertensive women. Significance of plasma renin activity values
    E A Karpanou
    Department of Cardiology, University of Athens, Hippokration Hospital, Greece
    Am J Hypertens 6:654-9. 1993
    ..not been studied in hypertensive women in relationship to changes in sex hormone levels and plasma renin activity (PRA)...
  59. ncbi [Influence of angiotensin on the secretion of aldosterone in idiopathic hyperaldosteronism]
    M Salvador
    , , Toulouse
    Arch Mal Coeur Vaiss 80:992-4. 1987
    ..49 +/- 11 years with idiopathic primary aldosteronism due to bilateral adrenal hyperplasia: plasma renin activity (PRA) less than 1.5 ng/ml/h and plasma aldosterone (PA) greater than 25 ng/100 ml...
  60. ncbi Plasma renin activity and norepinephrine as predictors for antihypertensive effects of nifedipine and captopril
    M Kusaka
    Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan
    Am J Hypertens 4:735-9. 1991
    ..5 to 75 mg/day. Blood pressure was measured every 2 weeks. Plasma renin activity (PRA), and plasma concentrations of aldosterone, epinephrine and norepinephrine were determined before and at the end of ..
  61. ncbi [Atrial natriuretic factor, catecholamines and the renin-angiotensin system in cardiac insufficiency. Relation to hemodynamic parameters]
    M Komajda
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 81:845-53. 1988
    ..factor (ANF), catecholamines (adrenaline, noradrenaline, dopamine) and aldosterone, and plasma renin activity (PRA) were measured in a group of 20 patients with moderate to medium heart failure (NYHA class II 7 patients, class III ..
  62. ncbi Reductions in total and extracellular water associated with calcium-induced natriuresis and the antihypertensive effect of calcium in blacks
    M B Zemel
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202
    Am J Hypertens 1:70-2. 1988
    ..Ca intake caused significant increases in supine systolic and diastolic pressure, reduced plasma renin activity (PRA), significantly increased TBW, and caused a significant reduction in total body reactance indicating an increase in ..
  63. ncbi Renal hypertensive angiopathy. Comparison between chronic NO suppression and DOCA-salt intoxication
    Y Xu
    INSERM U28, Paris, France
    Am J Hypertens 8:167-76. 1995
    ..Arterial wall cyclic guanosine monophosphate, plasma renin activity (PRA), and renal renin storage were assessed in parallel...
  64. ncbi The relationship between the sympathetic nervous system and the renin-angiotensin system in renovascular hypertension
    A Karagiannis
    B Propedeutic Department of Internal Medicine, Aristotelian University of Thessaloniki, Greece
    Acta Cardiol 49:425-34. 1994
    ..Plasma noradrenaline (plNA) levels and plasma renin activity (PRA) were measured simultaneously in blood samples obtained both from a peripheral vein and from the renal veins, ..
  65. ncbi [Natural history of arterial hypertension due to primary hyperreninism]
    P Cluzel
    , CHU, Clermont-Ferrand
    Arch Mal Coeur Vaiss 81:89-92. 1988
    ..Hypokalemic alkalosis, a 45 mm Sokolow index (SI) and very high peripheral renin activity (PRA) were also noticed...
  66. ncbi Natriuretic hormones in young hypertensives and in young normotensives with or without a family history of hypertension
    A Musca
    Institute of I Clinica Medica, Andrea Cesalpino Foundation, University of Rome La Sapienza, Italy
    Am J Hypertens 5:592-9. 1992
    ..2 +/- 1.9 years) and 16 normotensives (mean age 22.0 +/- 2.1 years). An inverse correlation between ANF and PRA was shown in all groups. In hypertensives, ANF was inversely correlated with uKK (r = -0.664, P less than .0001)...
  67. ncbi Diagnostic uses of angiotensin-converting enzyme inhibitors in renovascular hypertension
    C S Wilcox
    Department of Medicine, University of Florida College of Medicine, Gainesville
    Am J Hypertens 1:344S-349S. 1988
    ..Second, an exaggerated rise in plasma renin activity (PRA) after short-term captopril administration is a very promising screening test for this condition...
  68. ncbi [Pregnancy-induced hypertension and pre-eclampsia develop in spite of high circulating levels of cardionatrin]
    P Fievet
    Service de Nephrologie, CHU Amiens, France
    Arch Mal Coeur Vaiss 80:936-41. 1987
    ..preeclampsia (PE) and again 2 months after delivery in respectively 7, 15 and 7 cases together with plasma volume, PRA and plasma aldosterone...
  69. ncbi The influence of dietary salt and plasma renin activity on myosin heavy chain gene expression in rat hearts
    P Buttrick
    Montefiore Medical Center, Bronx, NY 10467
    Am J Hypertens 6:579-85. 1993
    ..In order to explore this, we studied rats that had elevated plasma renin activity (PRA) secondary to 6 weeks of either dietary salt restriction or renovascular hypertension (Htn)--conditions that exert ..
  70. ncbi The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy
    E R Maccariello
    Hypertension Clinic of the Laboratory of Clinical and Experimental Pathophysiology-CLINEX, Rio de Janeiro State University, Brazil
    Am J Hypertens 10:541-5. 1997
    ..excretion (UNaV), urinary kallikrein excretion (UKal), urinary albumin excretion (UAE), and plasma renin activity (PRA)...
  71. ncbi Role of dietary potassium in the hyperaldosteronism and hypertension of the remnant kidney model
    H N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis, USA
    J Am Soc Nephrol 11:625-31. 2000
    ..24-h protein excretion, plasma aldosterone levels, 24-h urinary aldosterone excretion, and plasma renin activity (PRA) were determined in all groups at 2 wk...
  72. ncbi Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone
    M Follenius
    Laboratoire de Physiologie et de Psychologie Environnementales, CHU, Strasbourg, France
    Sleep 14:211-7. 1991
    To assess the effect of obstructive sleep apnea treatment on plasma renin activity (PRA) and plasma aldosterone seven male patients were studied under two conditions: untreated and treated with nasal continuous positive airways pressure (..
  73. ncbi Hemodynamic responses to converting enzyme inhibition in patients with renal disease
    P August
    Cardiovascular Center, New York Hospital-Cornell University Medical College, NY 10021
    Am J Hypertens 2:599-603. 1989
    We studied the effects of lisinopril on mean arterial blood pressure (MAP), plasma renin activity (PRA), and renal hemodynamics in nine patients with chronic renal disease and hypertension, before, and after three months of therapy...
  74. ncbi [Sequential study of the plasmatic atrial natriuretic factor and the urinary excretion of an ouabain displacing factor and of dopamine in normotensive pregnant women before and after labor]
    N el Esper
    , CHRU, , Amiens, France
    Arch Mal Coeur Vaiss 82:1057-61. 1989
    ..Simultaneous estimation of plasma 99-126 atrial natriuretic factor (ANF), plasma renin activity (PRA) and plasma aldosterone were also undertaken...
  75. pmc Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits
    M Chamelian
    Department of Pharmacology, School of Medicine, , , Canada
    Br J Pharmacol 113:317-23. 1994
    ..dehydrated animals, baseline values of plasma arginine vasopressin (AVP) concentrations and plasma renin activity (PRA) were higher than in controls, i.e. 12.4 +/- 1.4 pg ml-1 and 15.4 +/- 1.7 ng AI ml-1 h-1 vs. 3.4 +/- 0...
  76. ncbi Regulation of cell specific expression of calcyclin (S100A6) in nerve cells and other tissues
    W Lesniak
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Center of Excellence, 3 Pasteur St, 02 093 Warsaw, Poland
    Acta Neurobiol Exp (Wars) 60:569-75. 2000
    ..Similarly to other members of the S100 protein family, calcyclin (S100A6) is expressed in a cell specific manner and is found in subpopulations of neurons and astrocytes in the ..
  77. ncbi A calcium binding protein, calbindin-D9k, is mainly regulated by estrogen in the pituitary gland of rats during estrous cycle
    Thi Hoa Nguyen
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    Brain Res Mol Brain Res 141:166-73. 2005
    As a member of family of cytosolic calcium binding proteins, Calbindin-D9k (CaBP-9k) is expressed in female reproductive system and regulated by steroid hormones, estrogen (E2) and progesterone (P4), but its expression and role in ..
  78. doi The effect of glucagon-like peptide 2 injection on performance, small intestinal morphology, and nutrient transporter expression of stressed broiler chickens
    X F Hu
    The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P R China
    Poult Sci 89:1967-74. 2010
    ..sodium and glucose co-transporter 1 (SGLT-1), vitamin D-dependent calcium-binding protein-28,000 molecular weight (CaBP-D28k), and peptide transporter 1 (PepT-1) mRNA in the duodenum and of liver fatty acid-binding protein (L-FABP) ..
  79. ncbi Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY
    M Pedrocchi
    Department of Pediatrics, University of Zurich, Switzerland
    Biochemistry 33:6732-8. 1994
    The S100 proteins CAPL and CACY are expressed in a tissue- and cell-specific manner and have been reported to be associated with the metastatic phenotype of tumor cells...
  80. ncbi An algorithm for cadaver kidney allocation based on a multivariate analysis of factors impacting on cadaver kidney graft survival and function
    F Poli
    Centro Trasfusionale e di Immunologia dei Trapianti, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Milan, Italy
    Transpl Int 13:S259-62. 2000
    ..It works in two steps (local pool first, then the entire waiting list) and four levels (0-1 HLA MM, PRA+; 2 HLA MM, PRA+; 0-1 MM, PRA-; 2-4 HLA MM, PRA-); within each level, selection takes into account waiting time and ..
  81. ncbi Effect of tamoxifen on endometrial histology, hormone receptors, and cervical cytology: a prospective study with follow-up
    Kimberly K Leslie
    Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, USA
    Appl Immunohistochem Mol Morphol 15:284-93. 2007
    ..due in part to differences in effect on estrogen and progesterone receptors [ER, progesterone receptor isoform A (PRA), and progesterone receptor isoform B (PRB)]...
  82. ncbi Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 74:799-804. 2002
    ..The use of flow cytometry based panel reactive antibody (flow-PRA) provides a highly sensitive means to identify the development of de novo anti-HLA antibodies in lung recipients.
  83. doi Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs
    Itsuro Matsumoto
    Department of Physiology, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R689-98. 2008
    ..An infusion of 37.5 microg/kg C48/80 into the cerebral third ventricle evoked increases in plasma renin activity (PRA), and in plasma epinephrine (Epi) and ADH concentrations...
  84. ncbi The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension
    Bert Jan H van den Born
    Department of Internal and Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Am J Hypertens 20:900-6. 2007
    ..A proposed mechanism for ongoing RAS activation is the presence of microangiopathic hemolysis resulting in renovascular ischemia...
  85. pmc Effects of proteinase A on cultivation and viability characteristics of industrial Saccharomyces cerevisiae WZ65
    Hong Bo Zhang
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
    J Zhejiang Univ Sci B 10:769-76. 2009
    Proteinase A (PrA), encoded by PEP4 gene, is a key enzyme in the vacuoles of Saccharomyces cerevisiae. We characterized the effects of PrA on cell growth and glucose metabolism in the industrial S. cerevisiae WZ65...
  86. ncbi Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    J Clin Endocrinol Metab 85:1863-7. 2000
    ..in patients with essential hypertension (EH) when determinations of serum aldosterone (SA), plasma renin activity (PRA), and the SA/PRA ratio are used as screening...
  87. doi Central choline suppresses plasma renin response to graded haemorrhage in rats
    Naciye Isbil-Buyukcoskun
    Department of Physiology, Uludag University Medical School, Bursa, Turkey
    Clin Exp Pharmacol Physiol 35:1023-31. 2008
    ..Plasma renin activity (PRA), which serves as an index of the function of the peripheral renin-angiotensin system, was determined in rats ..
  88. ncbi Effect of initial subcellular localization of progesterone receptor on import kinetics and transcriptional activity
    Henan Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, USA
    Mol Pharm 2:509-18. 2005
    ..There are two isoforms of PR, PRA and PRB. In most cell contexts, the PRA isoform is a repressor of the PRB isoform...
  89. ncbi Immunolocalization of the calcium binding S100A1, S100A5 and S100A6 proteins in the dog cochlea during postnatal development
    A G Coppens
    Laboratory of Anatomy and Embryology, Veterinary Anatomy, Faculty of Medicine, Free University of Brussels, 808 Lennik Street, B 1070 Brussels, Belgium
    Brain Res Dev Brain Res 126:191-9. 2001
    ..birth to 3 months were treated with polyclonal antisera raised against the human recombinant S100A1, S100A5, and S100A6 proteins...
  90. ncbi Prolonged exercise following diuretic-induced hypohydration effects on fluid and electrolyte hormones
    B D Roy
    Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1 Canada
    Horm Metab Res 33:540-7. 2001
    ..05) between conditions at rest were noted for plasma renin activity (PRA) (0.62 +/- 0.09 vs. 5.61 +/- 0.94 ng/ml/h), angiotensin I (ANG 1) (0.26 +/- 0.03 vs. 0.56 +/- 0...
  91. ncbi Impact of human leukocyte antigen matching and recipients' panel reactive antibodies on two-year outcome in presensitized renal allograft recipients
    Hui lin Meng
    Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China
    Chin Med J (Engl) 122:420-6. 2009
    ..The production of panel reactive antibody (PRA) against human leukocyte antigen (HLA) is a major risk factor in presensitized recipients...
  92. pmc Is there a role for renin profiling in selecting chronic heart failure patients for ACE inhibitor treatment?
    P O Lim
    Cardiovascular Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 83:257-61. 2000
    ..It remains uncertain whether angiotensin converting enzyme (ACE) inhibitors benefit all heart failure patients or just those with renin-angiotensin-aldosterone system (RAAS) activation...
  93. ncbi Differential transcriptional and translational regulations of calbindin-D9k by steroid hormones and their receptors in the uterus of immature mice
    Beum Soo An
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Korea
    J Reprod Dev 50:445-53. 2004
    Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium binding protein mainly expressed in the duodenum, placenta and uterus, and intestinal CaBP-9k is regulated by 1, 25-dyhydroxyvitamin D3...
  94. ncbi Primary hyperaldosteronism without suppressed renin due to secondary hypertensive kidney damage
    W Oelkers
    Department of Medicine, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    J Clin Endocrinol Metab 85:3266-70. 2000
    Primary hyperaldosteronism is characterized by high plasma and urinary aldosterone and suppressed PRA. Renin suppression is due to aldosterone-dependent sodium retention and mild extracellular volume expansion...
  95. pmc Risk screening in a medicare/medicaid population administrative data versus self report
    C L Vojta
    Division of Geriatrics, Department of Medicine at the University of Pennsylvania, Philadelphia, USA
    J Gen Intern Med 16:525-30. 2001
    ..To compare the abilities of two validated indices, one survey-based and the other database-derived, to prospectively identify high-cost, dual-eligible Medicare/Medicaid members...
  96. pmc Operative strategies for diverticular peritonitis: a decision analysis between primary resection and anastomosis versus Hartmann's procedures
    Vasilis A Constantinides
    Imperial College London, Department of Biosurgery and Surgical Technology, St Mary s Hospital London, UK
    Ann Surg 245:94-103. 2007
    To compare primary resection and anastomosis (PRA) with and without defunctioning stoma to Hartmann's procedure (HP) as the optimal operative strategy for patients presenting with Hinchey stage III-IV, perforated diverticulitis.
  97. ncbi Urinary free cortisol is not a biochemical marker of hypertension
    Paola Krall
    Escuela de Graduados, Universidad Austral de Chile, Valdivia, Chile
    Am J Hypertens 20:459-65. 2007
    ..The aim of this study was to evaluate the effects of F in the renal salt and water reabsorption in essential hypertensive patients (EH)...
  98. ncbi Nonparallel effects of renin inhibitor treatment on plasma renin activity and angiotensins I and II in hypertensive subjects. An assay-related artifact
    F H Derkx
    Department of Internal Medicine I, University Hospital Dykzigt, Erasmus University, Rotterdam, The Netherlands
    Am J Hypertens 4:602-9. 1991
    Nonparallel effects of renin inhibitor treatment on plasma renin activity (PRA) and the plasma levels of angiotensins (ANG), as well as on blood pressure, have been observed in subjects with hypertension...
  99. ncbi S100A6 preferentially labels type C nevus cells and nevic corpuscles: additional support for Schwannian differentiation of intradermal nevi
    D R Fullen
    Department of Pathology, University of Michigan Hospitals, Ann Arbor, Michigan 48109 0602, USA
    J Cutan Pathol 28:393-9. 2001
    ..In intradermal nevi, we have evaluated the pattern of S100A6 protein, a form of S100 found in Schwann cells.
  100. ncbi Number, origins, and chemical types of rat pallidostriatal projection neurons
    H Kita
    Department of Anatomy and Neurobiology, The University of Tennessee Memphis, Memphis, Tennessee 38163, USA
    J Comp Neurol 437:438-48. 2001
    ..Immunostaining for the calcium binding protein calbindin-28K (CaBP) was used to identify the CaBP-poor sensorimotor and CaBP-rich associative Str regions and the corresponding CaBP-..
  101. ncbi [Effects of praeruptorin C on vascular hypertrophy, [Ca2+]i, collagen content and NO in renovascular and spontaneously hypertensive rats]
    M R Rao
    Department of Cardiovascular Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Yao Xue Xue Bao 36:165-9. 2001
    To study the effects of praeruptorin C (pra-C), a pure constituent isolated from "Qian-Hu", the roots of Peucedanum praeruptorum Dunn...

Research Grants63

  1. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..and p53-binding;(vii) the high resolution structure of apo-mts1 (sub-family 1), as determined by NMR, is more like S100A6 (sub-family 1) than S100B (sub-family 2) and enabled us to distinguish structural differences between the two S100 ..
  2. Role of ANG II in Maintaining Vascular Relaxation in Dahl S Rats
    Julian H Lombard; Fiscal Year: 2010
    ..in the regulation of their renin-angiotensin system (RAS) that result in chronically low plasma renin activity (PRA) and low circulating ANG " levels, even when they are normotensive and fed a normal salt (NS) diet (0.4% NaCI)...
  3. ALDOSTERONE, RENIN AND PROSTAGLANDINS IN MAN
    Richard Horton; Fiscal Year: 1980
    ..studies we find that ascites patients have 10-fold increase in PGE, that prostaglandin inhibitors reduce renin (PRA) and aldosterone, reverse angiotensin pressor resistance and markedly impair renal function (PAH and Creatining ..
  4. RACE, RENIN, GENES, RISK, AND DIABETIC NEPHROPATHY
    NORMAN HOLLENBERG; Fiscal Year: 2002
    ..extreme RAS activation at the renal tissue level Type 2 DM patients with very low plasma renin activity (PRA) and nephropathy...
  5. PETER SCOTT HEEGER; Fiscal Year: 2016
    ..concept 2 will involve identifying heart transplant candidates at high risk for antibody mediated injury (high PRA) and performing a pilot study to determine the safety and efficacy of desensitization using a combination of B cell ..
  6. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..a multicenter, randomized, and placebo controlled trial where 300 primary heart transplant recipients with a PRA of <10% will be randomized to conventional immunosuppression (tacrolimus, MMF and rapid steroid taper) versus ..
  7. Intermountain Pediatric Heart Disease Research Center
    L Luann Minich; Fiscal Year: 2010
    ..children develop end-stage heart disease and may be listed for heart transplantation, If panel reactive antibodies (PRA) are >10%, prospective cross matching is required, limiting the donor pool and increasing both morbidity and ..
  8. S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIES
    Walter Chazin; Fiscal Year: 2009
    ..b>S100A6 has been shown to interact physically and functionally with Siah-1 interacting protein (SIP), which Is an ..
  9. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..Aim 1, they clone, express, and generate antibodies to the remaining keratinocyte S100 proteins, S100A2, S100A4, S100A6, S100A8, and S100A9...
  10. AMERICAN SOCIETY OF HUMAN GENETICS PUBLIC HEALTH GENETICS FELLOWSHIP
    Joann A Boughman; Fiscal Year: 2011
    ..0920-0428 Public Burden Statement: Clearance Officer, 1600 Clifton Road, MS D-24, Atlanta, GA 30333, ATTN: PRA (0920-0428). Do not send the completed form to this address...
  11. Structure of calcyclin binding protein-S100A6 complex
    Walter Chazin; Fiscal Year: 2004
    ..In this proposal, we will determine the structure of the complex of S100A6 with its target calcyclin binding protein. The Polish team will clone, produce and characterize the protein...
  12. ATOMIC STRUCTURE OF SMOOTH MUSCLE CALDESMON
    Roberto Dominguez; Fiscal Year: 2004
    ..from the C-terminal domain of caldesmon, 3) To determine the apo and Ca2+-bound crystal structures of human calcyclin (a S100 protein), 4) To crystallize and determine the structure of a complex between Ca2+-calcyclin and a ..
  13. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..e., neuronal Ca2+ sensing (NCS) and calcium binding (CaBP) proteins, that are solely or highly expressed in neurons...
  14. Steven A Webber; Fiscal Year: 2016
    ..to assess the safety of the regimen in a pediatric population and to assess efficacy via evaluation of calculated PRA, antibody strength and complement fixing ability/IgG subclass and proportion of patients with negative cross-match ..
  15. David B Buller; Fiscal Year: 2016
    ..e., setting), and perceived environment and built shade in posttest with PRA users...
  16. Risk-Informed Interventions in Community Pharmacy: Implementation and Evaluation
    Michael R Cohen; Fiscal Year: 2010
    ..to apply what has been learned from more than a dozen detailed socio-technical probabilistic risk assessment (ST-PRA) models to improve medication safety in community pharmacies through risk informed interventions...
  17. NMR Studies of Protein Side-Chain Dynamics
    MARK A RANCE; Fiscal Year: 2012
    ..Two model systems, protein/DNA complexes and the CaBP calbindin D9k, have been selected for study that will allow key insights to be obtained regarding the role of side-..
  18. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2009
    ..maturation through in vivo and in vitro studies on the mechanism of progesterone action focusing on the roles of PRA and PRB isoforms...
  19. D3 Dopamine receptor signaling in the regulation of startle gating
    Wei Li Chang; Fiscal Year: 2010
    ..Preferential D3 agonists such as pramipexole (PRA) PD128907, or 7-OH- DPAT will be administered alone or after either SB277,011, a D3-selective antagonist, or L741,..
  20. DNA Recombinational Repair: Role of the p53 Tumor Suppressor Protein
    Simon N Powell; Fiscal Year: 2010
    ..to confirm the dual model of p53 function: a basal level of p53 controls RPA from triggering unwanted recombination events in S-phase, and that after DNA damage, p53 is released from PRA and can activate a cascade of stress responses.
  21. ANNE KATHLEEN RADCLIFF; Fiscal Year: 2015
    ..and post-exposure prophylaxis against pneumonic plague - which is associated with up to 60% mortality - and CABP (such as methicillin-resistant Staphylococcus aureus) are the initially targeted indications...
  22. Improving Obesity Outcomes Through Interactive Web-Based Clinical Skills Training
    BRADLEY TANNER; Fiscal Year: 2011
    ..improvement guides, patient health improvement tools, a resource center, and approximately 4 hours of AMA PRA Category 1 Credit". Innovation: The ImpactObesity...
  23. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HALCYON WATKINS; Fiscal Year: 1992
    ..will be assayed for NE, DA, E, sodium, potassium and creatinine whereas plasma will be assayed for aldosterone, PRA, NE, DA, E and creatinine. GFR will be calculated from the clearance of creatinine...
  24. VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLS
    MARK HAUSSLER; Fiscal Year: 1999
    ..a molecular comparison of 1,25(OH)2D3/VDR action on osteocalcin will be made with the effect on calbindin-D28k (CaBP) induction in cultured embryonic duodena...
  25. 14th International Conference on Dialysis Advances in CKD 2012
    Mary Carter; Fiscal Year: 2012
    ..The meeting is accredited for 19 AMA PRA Category I Continuing Medical Education (CME) credits by the University of Minnesota...
  26. Improved actions of nitrates and statins with L-arginine
    Ruth Caldwell; Fiscal Year: 2003
    ..heart failure using nitroglycerin (GTN) or isosorbide mononitrate (ISMN) and 2) statin therapy [pravastatin (PRA) or simvastatin (SIM)] for unstable angina and stroke, by their combination with L-arginine (L-arginine)...
  27. 13th International Conference on Dialysis Advances in CKD 2011
    Mary Carter; Fiscal Year: 2010
    ..The meeting is accredited for 19 AMA PRA Category I Continuing Medical Education (CME) credits by the University of Minnesota...
  28. The pigmentary system: securing a place in the sun
    Andrzej Slominski; Fiscal Year: 2009
    ..Methodist Healthcare designates this educational activity for a maximum of 26 AMA PRA Category 1 Credits...
  29. Geoffrey S Pitt; Fiscal Year: 2016
    ..In the second aim, we recognize that CaM is but one Ca2+ binding protein (CaBP) that regulates ion channel function;in vivo Ca2+-sensitivity of ion channel function might reflect a convergence ..
  30. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..Using cultures derived from PRA null or PRB null mice we will also determine the role of the two PR isoforms (A and B) in proliferation and ..
  31. COMPLEMENTARY DNA PROBES TO A STEROID RECEPTOR GENE
    J Pike; Fiscal Year: 1992
    ..will be made by employing natural and cloned target gene promoters as reporter genes for transcriptional activity (CaBP, osteocalcin, MMTV)...
  32. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..Studies will be focused on renal calbindin-D9k (CaBP-D9k), the rate-limiting protein involved in transcellular calcium transport, and atrial natriuretic peptide (ANP), ..
  33. Reducing Risks by Engineering Resilience into Health Information Technology for E
    Robert L Wears; Fiscal Year: 2010
    ..To mitigate the hazards identified in the previously conducted proactive risk assessment (PRA) with respect to information technology (IT) related failures in the emergency department (ED) setting. 2...
  34. CABP GENE INTERACTION WITH VITAMIN D3 RECEPTOR
    Barry Komm; Fiscal Year: 1991
    ..The transcription of the calcium binding protein gene (CaBP-28k) in the intestine demonstrates an apparent absolute requirement for 1,25(OH)2 D3...
  35. RENAL FUNCTION IN PROTEIN DEFICIENCY
    MANUEL MARTINEZ MALDONADO; Fiscal Year: 1990
    ..We have also found reduced peripheral renin (PRA) and aldosterone activity, resistance to the hypertensive effects of exogenous norepinephrine (NE) and increased ..
  36. PROGESTERONE RECEPTORS IN BREAST CANCER
    KATHRYN HORWITZ; Fiscal Year: 1999
    ..naturally occurring isoforms -- the 120 kDa B-receptors (PRB) and the N-terminally truncated 94 kDa A- receptors (PRA)...
  37. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2007
    ..IL-l[3-induced NF-KB activity is required to upregulate transcripts encoding CaZ+-binding proteins (CaBP), including calreticulin, calbindin-3, and DSCR1...
  38. Using risk models to identify and prioritize outpatient 'high-alert' medications
    Michael Cohen; Fiscal Year: 2007
    ..system mapping, modified failure mode and effects analysis, and socio-technical probabilistic risk assessment (ST-PRA)...
  39. DRUG SUSCEPTIBILITY ASSAY FOR HCMV CLINICAL ISOLATES
    ROBYN MCGUIRE; Fiscal Year: 1999
    ..This assay was compared to the plaque reduction assay (PRA) to determine the drug susceptibility to ganciclovir, foscarnet and cidofovir of over 30 HCMV clinical isolates...
  40. Risk Models to Improve Long-Term Care Medication Safety
    GRANT HIGGINSON; Fiscal Year: 2003
    ..Working hypothesis: Sociotechnical probabilistic risk assessment (ST-PRA) can create risk models identifying common medication system and behavioral elements that raise the risk of serious ..
  41. MOLECULAR STRATEGIES TOWARDS A COCCIDIOIDOMYCOSIS VACCIN
    Theo Kirkland; Fiscal Year: 2003
    ..Project I focuses on antigen identification, expression, and preliminary testing. Project II will evaluate PRA as a protective antigen in detail...
  42. CAPTOPRIL AND ANGIOTENSIN VASCULAR EFFECTS IN SENESCENCE
    James Voelker; Fiscal Year: 1993
    ..A number of studies have documented age-associated reductions in plasma renin activity (PRA) and plasma aldosterone concentration...
  43. Risk and Recovery in Complex Environments: L&D as a Mod*
    Marlene Goldman; Fiscal Year: 2003
    ..As a foundation we will use probabilistic risk assessment (PRA) methodologies that have proven useful in engineering and industrial domains...
  44. Regulation of neuronal calcium channels by CaBP1
    Amy Lee; Fiscal Year: 2007
    ..1, but has surprisingly different effects than CaM in regulating Cav2.1 function. A splice variant of CaBP 1, caldendrin, also associates with Cav2.1 channels both in transfected cells and in the brain...
  45. MECHANISMS OF RISK TO DIABETIC NEPHROPATHY IN BLACKS
    Deborah Price; Fiscal Year: 2003
    ..extreme RAS activation at the renal tissue level in Type II DM patients with very low plasma renin activity (PRA) and nephropathy...
  46. PURINE BIOSYNTHESIS ENZYMES-MECHANISMS AND REGULATION
    JoAnne Stubbe; Fiscal Year: 2003
    ..The product of PurF, the first enzyme in the pathway, is the chemically unstable phosphoribosylamine (PRA)...
  47. CALCIUM BINDING PROTEINS: STRUCTURE AND FUNCTION
    John Moffat; Fiscal Year: 1980
    The goals can be simply summarized: a) To complete the structure determination of bovine CaBP, and to initiate crystallographic refinement; b) To complete the study of ion binding of CaBP, monitored by terbium fluorescence enhancement; c) ..
  48. STRUCTURE/FUNCTION STUDIES OF THE VITAMIN D RECEPTOR
    G Whitfield; Fiscal Year: 1993
    ..of normal or mutagenized receptor in transfected cells, b) the cloned 5' region of the calcium-binding protein (CaBP) gene, a gene known to be induced at the level of transcription by the VDR, and c) recipient cell lines which are ..
  49. GERIATRIC DENTISTRY FOR THE ALZHEIMER'S PATIENT
    Anthony Iacopino; Fiscal Year: 1990
    1. elucidate the relationship of the 28k Vitamin D-induced Calcium Binding Protein (CaBP) to, and its role in Alzheimer's disease...
  50. PLATELET CALCIUM-BINDING PROTEIN STRUCTURE & FUNCTION
    ELEANOR MC GOWAN; Fiscal Year: 1980
    ..project is designed to investigate the structure and function of a low molecular weight calcium-binding protein (CaBP) which I have purified from platelets...
  51. Socio-Technical Probabilistic Risk Assessment in Home Health Care
    Michael Silver; Fiscal Year: 2007
    ..and a systems-based review of 250 ACH events to develop a socio-technical probabilistic risk assessment (ST-PRA) model for ACH in the home [unreadable] health setting...
  52. Annual Forum: Hot Topics in OMM Research
    Peggy Smith Barbaro; Fiscal Year: 2005
    ..who are financially disadvantaged; and 4) provide 11 hours of continuing education Category 1A, AOA, Category 1 PRA/AMA, Type 1 TNA/ANCC credit to eligible participants...
  53. INFLUENCE OF ANGIOTENSIN ON VASOPRESSIN CONTROL
    JOHN CLAYBAUGH; Fiscal Year: 1980
    ..enzyme inhibitor during situations of physiologically and/or pathologically elevated plasma renin activity (PRA). PRA will be elevated by dehydration, low Na ion diet, and constriction of the renal artery...
  54. VITAMIN D ACTION IN THE AVIAN SHELL GLAND
    WILLIAM COTY; Fiscal Year: 1980
    ..of vitamin D on the levels of two shell gland proteins implicated in egg shell formation: calcium binding protein (CaBP) and calcium-stimulated ATPase...
  55. NEUROBEHAVIORAL BASES OF STRESS-INDUCED HYPERTENSION
    James Lawler; Fiscal Year: 1991
    ..function (GFR and RPF), direct blood pressure in resting animals, plasma assays for catecholamines, corticosterone, PRA, AVP, and ANP, as well as catecholamine levels in discrete brainstem and hypothalamic nuclei, using the Palkovits ..
  56. Proactive risk assessment in the ED: Building the 'safety case'
    Robert Wears; Fiscal Year: 2007
    ..are 3 broad, long-term objectives for this proposal: 1) to extend the techniques of proactive risk assessment (PRA) used in high hazard industries into a health care setting, 2) to adapt the technique of creating a 'safety ..
  57. Calcium channel modulation by CaBP1 during aging
    Amy Lee; Fiscal Year: 2002
    ..In addition, CaBP 1, a protein related to CaM, interacts with the CaM-binding domain of P/Q-type channels but causes a strong, Ca2+-..
  58. PRA-Chicago Transplant Insight Study
    Richard Cook; Fiscal Year: 2003
    DESCRIPTION (Provided by the Applicant): This application uses probabilistic risk assessment (PRA) to estimate the frequency of transplant donor/recipient mismatches...
  59. A PR-Induced Autocrine/Paracrine Pathway in Female Brain
    EDE APOSTOLAKIS; Fiscal Year: 2004
    ..been hampered by a lack of knowledge of the cell-lineages that express PR isoforms, mice with selective ablation of PRa (PRAKO) and PRb (PRBKO) will be studied...
  60. REGULATORY MECHANISMS IN CNS
    Wai Cheung; Fiscal Year: 1992
    ..sites of subunit B with subunit A of CaM-dependent phosphatase, and (4) characterize a novel Ca2+-binding protein (CaBP-20) from bovine brain and a novel Ca2+-binding protein (CaBP-15) from chick brain...
  61. TAS::75 0849::TAS FACILITATING THE TRANSFER OF STATISTICAL METHODOLOGY INTO PRA
    Dan Anbar; Fiscal Year: 2010
    ..The package will be acceptable for use in projects intended for submission to regulatory authorities and will be validated and documented to be 21 CFR Part 11 compliant. ..
  62. Improve Safety of Blood Product Transfusions in Children
    Anthony Slonim; Fiscal Year: 2005
    ..The quantitative and qualitative components will then be used to inform a probabilistic risk assessment (PRA) model for blood product transfusions in children...
  63. PHYSIOLOGICAL CONSEQUENCES OF PULMONARY DISEASE
    Peter Wagner; Fiscal Year: 2004
    ..of physical stress on lung matrix protein regulation, and also addresses the significance of stress-induced calcyclin gene expression to lung fibroblast cell division...