RSRC1

Summary

Gene Symbol: RSRC1
Description: arginine and serine rich coiled-coil 1
Alias: BM-011, SFRS21, SRrp53, serine/Arginine-related protein 53, arginine/serine-rich coiled-coil 1, arginine/serine-rich coiled-coil protein 1, splicing factor, arginine/serine-rich 21
Species: human

Top Publications

  1. pmc Discovery of recurrent structural variants in nasopharyngeal carcinoma
    Anton Valouev
    Division of Bioinformatics, Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90087, USA
    Genome Res 24:300-9. 2014
  2. doi RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β
    Lihan Chen
    Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing 100850, PR China
    FEBS Lett 589:1476-84. 2015
  3. pmc Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic
    Nadiya M Teplyuk
    Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    EMBO Mol Med 8:268-87. 2016
  4. pmc Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:501-12. 2013
  5. pmc A novel SR-related protein is required for the second step of Pre-mRNA splicing
    Demian Cazalla
    MRC Human Genetics Unit, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, Scotland, United Kingdom
    Mol Cell Biol 25:2969-80. 2005
  6. pmc Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia
    S G Potkin
    Department of Psychiatry and Human Behavior, Brain Imaging Center, University of California, Irvine, CA 92617, USA
    Mol Psychiatry 14:416-28. 2009
  7. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010

Research Grants

Scientific Experts

  • S G Potkin
  • Nadiya M Teplyuk
  • Lihan Chen
  • Anton Valouev
  • Sonja I Berndt
  • Demian Cazalla
  • Natalia Volfovsky
  • Jakub Godlewski
  • Anna M Krichevsky
  • Yang Wang
  • Galina Gabriely
  • Jian Teng
  • Athul Mohan
  • Bakhos Tannous
  • Ron Cialic
  • Priya Karmali
  • Merlene Peter
  • Erik J Uhlmann
  • Yevgenya Kraytsberg
  • Eric Marcusson
  • E Antonio Chiocca
  • Baiyu Han
  • Wen Ren
  • Weiyi Qiu
  • Qinong Ye
  • Hao Zhang
  • Qincao Li
  • Lei Zhou
  • Long Cheng
  • Weini Li
  • Ziming Weng
  • Arend Sidow
  • Sushama Varma
  • Quynh Thu Le
  • Robert T Sweeney
  • Robert B West
  • Christina Kong
  • Thomas W Mühleisen
  • Alan R Sanders
  • Veronique Vitart
  • Thomas W Winkler
  • Barbara McKnight
  • Lars Lind
  • Aarno Palotie
  • Nancy L Heard-Costa
  • Jianxin Shi
  • Jean Ferrieres
  • Mattias Lorentzon
  • M Carola Zillikens
  • John F Peden
  • Sarah E Medland
  • William O Cookson
  • Paolo Manunta
  • Elisabeth Widen
  • Patricia B Munroe
  • Ellen A Nohr
  • Goncalo R Abecasis
  • Per Hall
  • Carolin Pütter
  • Daniel I Chasman
  • Iris M Heid
  • John Beilby
  • Jaana Lindström
  • Femmie de Vegt
  • Amy J Swift
  • L Adrienne Cupples
  • Martin Farrall
  • Sarah E Hunt
  • Albertine J Oldehinkel
  • Igor Rudan
  • Antti Jula
  • Bernhard O Boehm
  • Boris Skrobek
  • Massimo Mangino
  • Andre G Uitterlinden
  • Stephen J Chanock
  • Timothy Frayling
  • Johan G Eriksson
  • Anne E Justice
  • Anthony J Balmforth
  • Joshua C Randall
  • Johanna Kuusisto
  • Sabine Schipf
  • Johannes Hebebrand
  • Dan Yu Lin
  • Olli Raitakari
  • Krista Fischer
  • Jennifer G Sambrook
  • Andrew R Wood
  • Paolo Brambilla

Detail Information

Publications7

  1. pmc Discovery of recurrent structural variants in nasopharyngeal carcinoma
    Anton Valouev
    Division of Bioinformatics, Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90087, USA
    Genome Res 24:300-9. 2014
    ..Our approach identified three in-frame gene fusions (YAP1-MAML2, PTPLB-RSRC1, and SP3-PTK2) that had strong levels of expression in corresponding NPC tissues...
  2. doi RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β
    Lihan Chen
    Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing 100850, PR China
    FEBS Lett 589:1476-84. 2015
    ..ERβ can be SUMOylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ERβ and SUMOylation of RSRC1 is required for regulation of PIAS1-mediated ERβ SUMOylation...
  3. pmc Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic
    Nadiya M Teplyuk
    Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    EMBO Mol Med 8:268-87. 2016
    ..splicing, often through the non-canonical targeting via 5'UTRs of its target genes, including MBNL1-3, SART3, and RSRC1. We have further assessed the inhibition of miR-10b in intracranial human GSC-derived xenograft and murine GL261 ..
  4. pmc Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
    Sonja I Berndt
    US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:501-12. 2013
    ..of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ..
  5. pmc A novel SR-related protein is required for the second step of Pre-mRNA splicing
    Demian Cazalla
    MRC Human Genetics Unit, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, Scotland, United Kingdom
    Mol Cell Biol 25:2969-80. 2005
    ..This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa)...
  6. pmc Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia
    S G Potkin
    Department of Psychiatry and Human Behavior, Brain Imaging Center, University of California, Irvine, CA 92617, USA
    Mol Psychiatry 14:416-28. 2009
    We have discovered two genes, RSRC1 and ARHGAP18, associated with schizophrenia and in an independent study provided additional support for this association...
  7. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..Several of these genes (RSRC1, ARHGAP18, ROBO1-ROBO2, GPC1, TNIK, and CTXN3-SLC12A2) have functions related to progenitor cell proliferation, ..

Research Grants1

  1. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..