RRAD

Summary

Gene Symbol: RRAD
Description: RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Alias: RAD, RAD1, REM3, GTP-binding protein RAD, RAS (RAD and GEM) like GTP binding 3, RRAD, Ras related glycolysis inihibitor and calcium channel regulator, Ras-related associated with diabetes, ras associated with diabetes
Species: human

Top Publications

  1. ncbi The structure and function of RAD6 and RAD18 DNA repair genes of Saccharomyces cerevisiae
    L Prakash
    Department of Biophysics, University of Rochester School of Medicine, NY 14642
    Genome 31:597-600. 1989
  2. ncbi Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans
    C Reynet
    Research Division, Joslin Diabetes Center, Boston, MA
    Science 262:1441-4. 1993
  3. ncbi Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells
    J S Moyers
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:23111-6. 1996
  4. ncbi Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
    J S Moyers
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:11832-9. 1997
  5. ncbi Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 14:1397-404. 2007
  6. pmc Evaluation of 99mtechnetium-radiopharmaceutical binding to blood elements using different trichloroacetic acid concentrations
    R S Freitas
    , , Rio de Janeiro, Brasil
    Yale J Biol Med 69:483-8. 1996
  7. pmc Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
    H Roche
    Department of Microbiology, University of Manitoba, Winnipeg, Canada
    Genetics 140:443-56. 1995
  8. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
  9. ncbi Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins
    M Bankmann
    Department of Biophysics, University of Rochester School of Medicine, New York 14642 8408
    Nature 355:555-8. 1992
  10. pmc Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae
    Y Tsukamoto
    Department of Molecular Biology, Univesity of Tokyo, Japan
    Genetics 142:383-91. 1996

Research Grants

  1. Lauren Endres; Fiscal Year: 2014
  2. RGK proteins and aging muscle
    ROGER ALAN BANNISTER; Fiscal Year: 2012
  3. Michael J Smerdon; Fiscal Year: 2014
  4. Matthew J O'Connell; Fiscal Year: 2015
  5. Variable Dose Rate X-ray Irradiator
    Howard B Lieberman; Fiscal Year: 2010
  6. Repair of Oxidatively Damaged Guanines
    A LIEN L LU-CHANG; Fiscal Year: 2013
  7. Anja Katrin Bielinsky; Fiscal Year: 2016
  8. Cooperative roles for Atm and Hus1 in genome maintenance
    Robert Weiss; Fiscal Year: 2009
  9. TRANSCRIPTION COFACTORS IN DIFFERENTIATION
    Yang Shi; Fiscal Year: 2011
  10. Temporal and Spatial Relationships of Proteins in Yeast NER
    PAULA FISCHHABER; Fiscal Year: 2009

Detail Information

Publications280 found, 100 shown here

  1. ncbi The structure and function of RAD6 and RAD18 DNA repair genes of Saccharomyces cerevisiae
    L Prakash
    Department of Biophysics, University of Rochester School of Medicine, NY 14642
    Genome 31:597-600. 1989
    ..Addition of the first four residues of the polyacidic tail restores sporulation to 50% the level observed in RAD+/RAD+ diploids...
  2. ncbi Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans
    C Reynet
    Research Division, Joslin Diabetes Center, Boston, MA
    Science 262:1441-4. 1993
    ..encoded a new 29-kilodalton member of the Ras-guanosine triphosphatase superfamily and was termed Rad (Ras associated with diabetes)...
  3. ncbi Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells
    J S Moyers
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:23111-6. 1996
    b>Rad is a Ras-like GTPase that was isolated by subtraction cloning of human muscle and shown to have increased expression in some individuals with Type II diabetes...
  4. ncbi Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II
    J S Moyers
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:11832-9. 1997
    Members of the Rad family of GTPases (including Rad, Gem, and Kir) possess several unique features of unknown function in comparison to other Ras-like proteins, with major N-terminal and C-terminal extensions, a lack of typical ..
  5. ncbi Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 14:1397-404. 2007
    b>RRAD, a small Ras-related GTPase, is highly expressed in human skeletal muscle, lung, and heart...
  6. pmc Evaluation of 99mtechnetium-radiopharmaceutical binding to blood elements using different trichloroacetic acid concentrations
    R S Freitas
    , , Rio de Janeiro, Brasil
    Yale J Biol Med 69:483-8. 1996
    ..5 and 0.1 percent) and soluble (SF) and insoluble fractions (IF) were isolated. The percent radioactivity (percent rad) in IF-P depends on TCA concentration. It varied from 36.4 to 65.0 (99mTc-PHY), from 17.9 to 32...
  7. pmc Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
    H Roche
    Department of Microbiology, University of Manitoba, Winnipeg, Canada
    Genetics 140:443-56. 1995
    ..to encode a DNA polymerase that specializes in translesion synthesis, we determined the REV3 dependence of the rad mutator specificities...
  8. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
    ..The conclusion that the yeast MEC1 gene is a key regulator also has implications for the role of a putative human homologue, the ATM gene...
  9. ncbi Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins
    M Bankmann
    Department of Biophysics, University of Rochester School of Medicine, New York 14642 8408
    Nature 355:555-8. 1992
    ..Mutations in any one of five yeast genes, RAD1, RAD2, RAD3, RAD4, and RAD10, cause a total defect in incision and an extreme sensitivity to ultraviolet light...
  10. pmc Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae
    Y Tsukamoto
    Department of Molecular Biology, Univesity of Tokyo, Japan
    Genetics 142:383-91. 1996
    ..Study on the effect of several rad mutations showed that the recombination rate was reduced by 30-, 10-, 10-, and 10-fold in the rad52, rad50, mre11, ..
  11. pmc Expression of the E.coli ada gene in S.cerevisiae provides cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine in rad6 but not in rad52 mutants
    J Brozmanova
    Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava
    Nucleic Acids Res 22:5717-22. 1994
    ..was introduced into the wild-type yeast strains, YNN-27 and FF-18733, and the repair deficient mutants LN-1 (rad1-1), VV-5 (rad6-1), C5-6 (rad52-1) and FF-18742 (rad52::URA3)...
  12. pmc Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:4907-11. 1993
    ..Repair synthesis in vitro was defective in extracts of rad1, rad2, and rad10 mutant cells, all of which have mutations in genes whose products are known to be required for NER ..
  13. pmc Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes
    F Prado
    , , Universidad de Sevilla, Spain
    Genetics 139:109-23. 1995
    ..Those deletion events initiated through a DSB in the unique intervening sequence require the Rad1/Rad10 endonuclease only if the break is distantly located from the flanking DNA repeats...
  14. pmc Human studies with synthetic peptide sporozoite vaccine (NANP)3-TT and immunization with irradiated sporozoites
    D A Herrington
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
    Bull World Health Organ 68:33-7. 1990
    ..P. falciparum-infected mosquitos were irradiated with 20,000 rad (200 Gy)...
  15. ncbi Arthropod touch reception: spider hair sensilla as rapid touch detectors
    J T Albert
    University of Vienna, Biocenter, Institute of Zoology, Wien, Austria
    J Comp Physiol A 187:303-12. 2001
    ..The torsional restoring constant S changes non-linearly with deflection angle. It is of the order of 10(-8) Nm/rad, which is about 10,000 times larger than for trichobothria...
  16. pmc The role of DNA repair genes in recombination between repeated sequences in yeast
    B Liefshitz
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
    Genetics 140:1199-211. 1995
    ..Among seven genes involved in excision repair tested, only RAD1 and RAD10 played a role in the types of recombination studied...
  17. pmc Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro
    M Biggerstaff
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 12:3685-92. 1993
    ..The data suggest that ERCC1 is part of a functional protein complex with group 4 and XP-F correcting activities. The latter two may be equivalent to one another and analogous to S. cerevisiae RAD1.
  18. ncbi Genetic evidence for different RAD52-dependent intrachromosomal recombination pathways in Saccharomyces cerevisiae
    A Aguilera
    , , Universidad de Sevilla, Spain
    Curr Genet 27:298-305. 1995
    ..However, they enhance the frequency of deletions between direct repeats 5-12-fold. These induced deletions are RAD1- and RAD52-dependent...
  19. ncbi Cisplatin DNA cross-links do not inhibit S-phase and cause only a G2/M arrest in Saccharomyces cerevisiae
    K F Grossmann
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Mutat Res 434:29-39. 1999
    ..mec1, mec3 and rad53) showed increased sensitivity to CDDP, as did controls with a defect in excision repair (rad1 and rad14) or a defect in recombination (rad51 and rad52)...
  20. ncbi Establishment and biological properties of mouse granulocytic leukemic cell line-L833
    X L Li
    Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing
    Sci Sin B 31:328-37. 1988
    ..It was also sensitive to ionizing radiation. D0 values of L833 and L883-A cells were 98.8 and 104.9 rad, respectively. The results were similar to that of L801...
  21. doi Immune responses of recombinant adenoviruses expressing immunodominant epitopes against Japanese encephalitis virus
    Peng Li
    Key Laboratory of Animal Disease Diagnosis and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vaccine 26:5802-7. 2008
    ..Intramuscular immunization of mice with rAd-TEP generated greater titers of anti-JEV antibodies and JEV neutralizing activity than in animals with oral ..
  22. ncbi Analysis of spontaneous and double-strand break-induced recombination in rad mutants of S. pombe
    E A Fortunato
    Department of Biology, University of California San Diego, La Jolla 92093 0322, USA
    Mutat Res 364:14-60. 1996
    ..In S. cerevisiae, the DSB/gap repair pathway is RAD52 dependent, and the RAD1 and RAD10 genes are involved in the SSA pathway...
  23. ncbi Stability of YACs containing ribosomal or RCP/GCP locus DNA in wild-type S. cerevisiae and RAD mutant strains
    K Kohno
    Department of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University, Japan
    DNA Res 1:191-9. 1994
    ..5 rDNA tandem repeat units were transformed into hosts bearing lesions at the RAD1, RAD6, RAD51, or RAD52 loci...
  24. ncbi Analysis of gene- and strand-specific repair in the moderately UV-sensitive Saccharomyces cerevisiae rad23 mutant
    R A Verhage
    Laboratory of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, The Netherlands
    Mutat Res 362:155-65. 1996
    ..The rad23 mutation does not suppress the high UV sensitivity of completely NER-deficient rad1 or rad14 strains...
  25. ncbi Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants
    P Perego
    Department of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Mol Pharmacol 54:213-9. 1998
    ..1-21.7-fold hypersensitive; only rad1 and -3 mutants, defective in checkpoints, and rad18, defective in repair, displayed a marked hypersensitivity...
  26. doi Prevalence and risk factors in postoperative pancreatitis after spine fusion in patients with cerebral palsy
    Battugs Borkhuu
    Department of Orthopedics, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    J Pediatr Orthop 29:256-62. 2009
    ..The aim of this study was to assess the association between preoperative comorbidities and other parameters in the development of pancreatitis after spinal fusion surgery in a sample of children with CP...
  27. ncbi Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins
    M C Rosenhagen
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Chem 382:499-504. 2001
    Radicicol (RAD) and the benzoquinone ansamycin geldanamycin (GA) are potential anticancer drugs known to inhibit heat shock protein 90 (hsp90) and, therefore, the activation of proteins dependent on its function such as proto-oncogenic ..
  28. ncbi Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0726, USA
    Crit Care Med 31:2421-8. 2003
    ..bioartificial kidney consisting of a conventional hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 109 renal proximal tubule cells may be a new therapeutic approach to this clinical disorder.
  29. ncbi Comparison of ampholytes used for slab gel and capillary isoelectric focusing of recombinant tissue-type plasminogen activator glycoforms
    A B Chen
    Department of Quality Control Clinical Development, Genentech Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 744:279-84. 1996
    Four commercial ampholytes: Ampholine and Pharmalyte (Pharmacia Biotech), Bio-Lyte (Bio-Rad) and Servalyt (Serva) were evaluated for their ability to resolve recombinant tissue-type plasminogen activator (rt-PA) glycoforms by isoelectric ..
  30. ncbi Triplet- vs. singlet-state imposed photochemistry. The role of substituent effects on the photo-Fries and photodissociation reaction of triphenylmethyl silanes
    Antonios K Zarkadis
    Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
    Photochem Photobiol Sci 4:469-80. 2005
    ..of 1* is a one-quantum process and takes place via the carbonyl triplet excited state with high quantum yield (Phi(rad)= 0...
  31. ncbi Comparative thermal stabilities of recombinant adenoviruses and hexon protein
    Peter M Ihnat
    Biotechnology Development, Schering Plough Research Institute, Union, NJ 07081 3121, USA
    Biochim Biophys Acta 1726:138-51. 2005
    ..of the replication deficient and protein IX deleted recombinant adenovirus type 5 that contains the p53 transgene (rAd/p53) in phosphate buffered saline (vPBS) or 10% glycerol (TRIS/phosphate buffer)...
  32. ncbi Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin
    Bernd Kinzel
    Department of Functional Genomics, Novartis Pharma AG, Basel, Switzerland
    Cancer 94:1808-14. 2002
    ..Hus1 has been shown to exist in a discrete complex with at least two Rad family members, Rad1 and Rad9...
  33. doi Phosphorylation and cytoplasmic localization of MAPK p38 during apoptosis signaling in bone marrow granulocytes of mice irradiated in vivo and the role of amifostine in reducing these effects
    Helena R C Segreto
    Department of Clinical and Experimental Oncology, Radiotherapy Division, Federal University of Sao Paulo, UNIFESP, Rua Pascal 778, Sao Paulo, SP, Brazil
    Acta Histochem 113:300-7. 2011
    ..Sixty-four C57BL mice were randomly assigned in two non-irradiated (Ami-/rad- and Ami+/rad-) and two irradiated (Ami-/rad+ and Ami+/rad+) groups. Animals received 400mg/kg of amifostine i.p...
  34. ncbi Function of pokeweed mitogen-stimulated human T cells following vaccination with pneumococcal polysaccharides
    C Heilmann
    Department of Medical Immunology, Rigshospitalet, Copenhagen, Denmark
    Acta Pathol Microbiol Immunol Scand C 95:207-12. 1987
    ..Irradiation (2300 rad) of T cells from day 0 increased the numbers of anti-PPS-SC in the cultures significantly (three times), whereas ..
  35. ncbi Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice
    E G Stefanich
    Genentech Inc, South San Francisco, CA, USA
    Cancer Chemother Pharmacol 47:70-7. 2001
    ....
  36. doi CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine
    Jun Cao
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Vaccine 28:7514-22. 2010
    ..The results showed that rAd-CD40L-GP35 (co-expressing CD40L and GP3-GP5) or rAd-GP35 (expressing GP3-GP5) plus rAd-CD40L (expressing CD40L) ..
  37. ncbi Holliday junction cleavage by yeast Rad1 protein
    Y Habraken
    Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston 77555 1061
    Nature 371:531-4. 1994
    In Saccharomyces cerevisiae, of the many genes required for excision repair of ultraviolet-damaged DNA, only RAD1 and RAD10 also function in genetic recombination...
  38. ncbi Muscle fatigue induced by exercise simulating the work rate of competitive soccer
    N Rahnama
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 21:933-42. 2003
    ..001) in peak torque for both the quadriceps and hamstrings at all angular velocities (concentric: 1.05, 2.09, 5.23 rad x s(-1); eccentric: 2.09 rad x s(-1))...
  39. pmc Yttrium-90 ibritumomab tiuxetan doses calculated to deliver up to 15 Gy to critical organs may be safely combined with high-dose BEAM and autologous transplantation in relapsed or refractory B-cell non-Hodgkin's lymphoma
    Jane N Winter
    Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 27:1653-9. 2009
    To determine the maximum-tolerated radiation-absorbed dose (RAD) to critical organs delivered by yttrium-90 ((90)Y) ibritumomab tiuxetan in combination with high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) chemotherapy ..
  40. ncbi Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease
    A J Bardwell
    Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center at Dallas 75235
    Science 265:2082-5. 1994
    The RAD1 and RAD10 genes of Saccharomyces cerevisiae are required for both nucleotide excision repair and certain mitotic recombination events...
  41. ncbi In vivo radioprotective effects of oltipraz in gamma-irradiated mice
    S G Kim
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Biochem Pharmacol 55:1585-90. 1998
    Previous studies in this laboratory have shown that oltipraz (Olt), a chemopreventive agent, enhances radiation(Rad)-inducible glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) expression in the liver...
  42. ncbi Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics
    H D Humes
    Department of Internal Medicine, University of Michigan, VA Medical Center, Ann Arbor, USA
    Kidney Int 55:2502-14. 1999
    ..This therapy is not complete renal replacement therapy because it does not provide active transport nor metabolic and endocrinologic functions of the kidney, which are located predominantly in the tubular elements of the kidney...
  43. ncbi Antioxidant properties of ursodeoxycholic acid
    Domenico Lapenna
    Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, 66100 Scalo, Chieti, Italy
    Biochem Pharmacol 64:1661-7. 2002
    ..09 and 29 mM, respectively, in human plasma and bile. UDCA was an excellent scavenger of OHz.rad; generated by FeCl(3)-EDTA, H(2)O(2) and ascorbate in the deoxyribose oxidation test, showing IC(min) and IC(50) ..
  44. ncbi Bone or cartilage invasion by advanced head and neck cancer: intra-arterial supradose cisplatin chemotherapy and concomitant radiotherapy for organ preservation
    S Samant
    Department of Otolaryngology Head and Neck Surgery, University of Tennessee Health Sciences Center, 956 Court Ave, Suite B 222, Memphis, TN 38163, USA
    Arch Otolaryngol Head Neck Surg 127:1451-6. 2001
    ..At University of Tennessee-Memphis, patients with advanced head and neck cancer have been treated on a protocol of concomitant intra-arterial (targeted) cisplatin and conventional radiation therapy...
  45. doi Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats
    Murat Caloglu
    Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Clin Exp Pharmacol Physiol 36:523-30. 2009
    ..2. Seventy-one Albino rats were randomly divided into six groups as follows: (i) AMI + RAD (n = 15), 200 mg/kg, i.p...
  46. ncbi A comparison of three site-directed mutagenesis kits
    P Loke
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Z Naturforsch C 56:810-3. 2001
    ..comparative study, three different mutagenesis kits, namely the MutaGene phagemid in vitro mutagenesis kit (Bio-Rad), the Transformerä Site-Directed mutagenesis kit (Clontech) and the Quik-change site-directed mutagenesis kit (..
  47. ncbi Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low
    B Hausen
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305, USA
    Transplantation 69:488-96. 2000
    ..but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin)...
  48. ncbi Rad is temporally regulated within myogenic progenitor cells during skeletal muscle regeneration
    Thomas J Hawke
    School of Kinesiology and Health Science, York Univ, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    Am J Physiol Cell Physiol 290:C379-87. 2006
    ..Herein we demonstrate the expression pattern and transcriptional regulation of Rad, a prototypical member of a family of novel Ras-related GTPases, during mammalian development and skeletal muscle ..
  49. ncbi Gender differences in the circadian variations in muscle strength assessed with and without superimposed electrical twitches
    Magali Giacomoni
    Laboratoire Ergonomie Sportive et Performance, UFR STAPS, Universite de Toulon Var, La Garde, France
    Ergonomics 48:1473-87. 2005
    ..Peak isokinetic torques (PT) of knee extensors and flexors were then measured at 1.05 rad s(-1) and 3.14 rad s(-1) through a 90 degrees range of motion...
  50. doi An evaluation of two commercially available ELISAs and one in-house reference laboratory ELISA for the determination of human anti-rabies virus antibodies
    Ryan J Welch
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    J Med Microbiol 58:806-10. 2009
    ..We compared the Bio-Rad Platelia Rabies II ELISA, DRG Rabies Virus IgG Ab ELISA and Focus Diagnostics Rabies Antibody Detection by ELISA to ..
  51. doi Efficient adenovirus-mediated gene transfer to gastric tissue by oral administration
    Xiao fei Liu
    Department of Clinical Microbiology and Immunology, Third Military Medical University, Chongqing, China
    J Gene Med 11:1087-94. 2009
    Recombinant adenoviruses (rAd) are well-characterized viral vectors and have been studied in many human diseases. However, there are no detailed methods for transferring genes to the stomach using rAd.
  52. ncbi ESR dating of elephant teeth and radiation dose rate estimation in soil
    T S Chong
    Department of Nuclear Engineering, Nagoya University, Japan
    Int J Rad Appl Instrum A 40:1199-202. 1989
    ..The 60Co gamma-ray equivalent accumulated dose of (2 +/- 0.2) x 10(4) rad for the tooth enamel gave "ESR age" of (9 +/- 2) x 10(4) y, which falls in the geologically estimated range between ..
  53. ncbi The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD
    V F Quesniaux
    Transplantation Research Department, Novartis Pharma, Basel, Switzerland
    Transpl Immunol 8:177-87. 2000
    ..Here, we investigated the susceptibility of cynomolgus monkeys to FTY720 given orally either alone or in combination with two other immunosuppressants, Cyclosporin Neoral or RAD, as an introductory study to transplantation protocols.
  54. ncbi Comparison of genotoxic potency of styrene 7,8-oxide with gamma radiation and human cancer risk estimation of styrene using the rad-equivalence approach
    Lode Godderis
    IDEWE, External Service for Prevention at Work, Interleuvenlaan 58, 3001 Heverlee, Belgium
    Mutagenesis 22:209-15. 2007
    ..genotoxic potency of styrene 7,8-oxide and gamma radiation in order to calculate the cancer risk by means of the rad-equivalence approach. Leucocytes of 20 individuals were exposed to 0, 0.1, 0.2 or 0...
  55. ncbi Influence of muscle architecture on the torque and power-velocity characteristics of young and elderly men
    Jeanette M Thom
    Institute for Biophysical and Clinical Research into Human Movement IRM, Manchester Metropolitan University, Alsager Campus, Hassall Road, Alsager, Cheshire, ST7 2HL, UK
    Eur J Appl Physiol 100:613-9. 2007
    ..Plantarflexors' (PF) maximal isometric and concentric torques were recorded at 0.87, 1.75, 2.62, 3.49 and 4.36 rad s(-1)...
  56. ncbi [Noninvasive assessment of forearm vessels by color Doppler ultrasonography (CDU) before and after radiocephalic fistula (RCF) placement]
    R Roca-Tey
    Servicio de Nefrologia, Hospital de Mollet, Barcelona
    Nefrologia 27:489-95. 2007
    ..The CDU is a noninvasive vascular access (VA) monitoring technique that provides both structural and hemodynamic information from vessels...
  57. ncbi Immune responses of two recombinant adenoviruses expressing VP1 antigens of FMDV fused with porcine granulocyte macrophage colony-stimulating factor
    Yijun Du
    Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing 210095, China
    Vaccine 25:8209-19. 2007
    ..designated VPe) or VP1 protein of FMDV fused with porcine granulocyte macrophage colony-stimulating factor (named rAd-GMCSF-VPe and rAd-GMCSF-VP1)...
  58. doi HSP70 fused with GP3 and GP5 of porcine reproductive and respiratory syndrome virus enhanced the immune responses and protective efficacy against virulent PRRSV challenge in pigs
    Junxing Li
    Nanjing Agricultural University, Nanjing 210095, China
    Vaccine 27:825-32. 2009
    ..The results showed that all animals vaccinated with rAd-GP35 (co-expressing GP3-GP5), rAd-HS35 and rAd-HSA35 (co-expressing GP3-GP5 fused with HSP70 using different ..
  59. doi A comprehensive index for assessing environmental stress in animals
    T L Mader
    Department of Animal Science, University of Nebraska, Concord 68728, USA
    J Anim Sci 88:2153-65. 2010
    ..However, no model has been found that incorporates adjustments for RH, WS, and radiation (RAD) over conditions that encompass hot and cold environmental conditions...
  60. ncbi Reduced orthostatic tolerance following 4 h head-down tilt
    G C Butler
    Department of Kinesiology, University of Waterloo, Ontario, Canada
    Eur J Appl Physiol Occup Physiol 62:26-30. 1991
    The cardiovascular responses to a 10-min 1.22 rad (70 degrees) head-up tilt orthostatic tolerance test (OST) was observed in eight healthy men following each of a 5-min supine baseline (control), 4 h of 0...
  61. pmc Genetic control of RNA polymerase I-stimulated recombination in yeast
    B R Zehfus
    Department of Biological Chemistry, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033
    Genetics 126:41-52. 1990
    ..Mutations in RAD1 and RAD52 decrease the ability of HOT1 to stimulate intrachromosomal recombination while mutations in RAD4 and ..
  62. pmc Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae
    N Erdeniz
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 2704, USA
    Mol Cell Biol 20:224-32. 2000
    In Saccharomyces cerevisiae, RAD1 and RAD52 are required for alternate pathways of mitotic recombination. Double-mutant strains exhibit a synergistic interaction that decreases direct repeat recombination rates dramatically...
  63. ncbi Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation
    L B Adams
    Laboratory Research Branch, GWL Hansen s Disease Center, Louisiana State University, Baton Rouge 70894, USA
    Int J Lepr Other Mycobact Dis 68:1-10. 2000
    ..gamma-Irr of up to 10(3) rad had little effect on the metabolic activity of either organism. For M...
  64. ncbi Reference database for bone speed of sound measurement by a novel quantitative multi-site ultrasound device
    M Weiss
    Endocrine Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    Osteoporos Int 11:688-96. 2000
    ..We report the reference database for SOS at the radius (RAD), tibia (TIB), metatarsus (MTR) and phalanx (PLX)...
  65. ncbi Retinal microvascular abnormalities in patients treated with external radiation for graves ophthalmopathy
    Dennis M Robertson
    Department of Ophthalmology, Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Ophthalmol 121:652-7. 2003
    ..Radiation was directed to the orbits of 42 affected patients using 0.2 rad (20 Gy) delivered in 10 doses of 0.02 rad (2 Gy). Patients were periodically examined during a 3-year interval.
  66. ncbi Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport
    Ramasubbu N Mahalakshmi
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Traffic 8:1164-78. 2007
    The members of the RGK small GTP-binding protein family, Kir/Gem, Rad, Rem and Rem2, are multifunctional proteins that regulate voltage-gated calcium channel activity and cell shape remodeling...
  67. doi Protective immune responses induced by in ovo immunization with recombinant adenoviruses expressing spike (S1) glycoprotein of infectious bronchitis virus fused/co-administered with granulocyte-macrophage colony stimulating factor
    Basit Zeshan
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Vet Microbiol 148:8-17. 2011
    ..The results showed that the chickens vaccinated in ovo with rAd-S1, rAd-GM-S1 (GM-CSF fused with S1 using glycine linkers) and rAd-GM-CSF plus rAd-S1 (co-administered) developed ..
  68. ncbi [Construction and immunogenicity of a recombinant adenovirus co-expressing the E2 protein of classical swine fever virus and the porcine interleukin 2 in rabbits]
    Lei He
    College of Veterinary Medicine, Northwest A and F University, Yangling 712100, China
    Bing Du Xue Bao 26:385-91. 2010
    ..resultant recombinant plasmid AdEasy-E2-pIL-2 was transfected into the 293 cells where the recombinant adenovirus rAd-E2-pIL-2 was produced. The immunogenicity of rAd-E2-pIL-2 was evaluated in rabbits...
  69. pmc Regulation of seed germination in the close Arabidopsis relative Lepidium sativum: a global tissue-specific transcript analysis
    Karl Morris
    School of Life Sciences, Warwick University, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Physiol 155:1851-70. 2011
    ..g. Arabidopsis [Arabidopsis thaliana]) is regulated by two opposing forces, the growth potential of the radicle (RAD) and the resistance to this growth from the micropylar endosperm cap (CAP) surrounding it...
  70. ncbi Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
    Jörg R Aschenbach
    Institute of Veterinary Physiology, University of Leipzig, Leipzig, Germany
    Scand J Gastroenterol 41:712-9. 2006
    ..Two enzymes are involved, namely histamine N-methyltransferase (HMT) and diamine oxidase (DAO). The purpose of this study was to find a link between histamine catabolism and the activities of HMT and DAO...
  71. ncbi Use of yeast for detection of endogenous abasic lesions, their source, and their repair
    Serge Boiteux
    Laboratory of Radiobiology DNA, Department of Radiobiology and Radiopathology, Aus Roses, France
    Methods Enzymol 408:79-91. 2006
    ..Data shows that the simultaneous inactivation of two AP endonucleases (Apn1 and Apn2) and of the nuclease Rad1-Rad10 causes cell death in Saccharomyces cerevisiae...
  72. ncbi Inoperable hepatocellular carcinoma: transarterial 188Re HDD-labeled iodized oil for treatment--prospective multicenter clinical trial
    Ajay Kumar
    Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Radiology 243:509-19. 2007
    ....
  73. ncbi Role of interleukin-1 receptor type II in the pathogenesis of endometriosis
    Zhen Hou
    Center of Clinical Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People s Republic of China
    Fertil Steril 89:42-51. 2008
    ..To determine the role of interleukin-1 receptor type II (IL-1RII) in the pathogenesis of endometriosis...
  74. doi Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus
    John G Hanly
    Division of Rheumatology, Capital Health and Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol Methods 358:75-80. 2010
    ..Autoantibodies were measured using the BioPlex 2200 ANA screen (Bio-Rad), QuantaPlex ENA8 (INOVA Diagnostics) and recomLine ANA/ENA (Mikrogen)...
  75. doi Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases
    Feng Ying Chang
    Department of Pediatrics, Shin Kong Wu Ho Su Memorial Hospital, 7 Chung Shan South Road, Taipei, Taiwan, Republic of China
    Int Arch Allergy Immunol 154:49-56. 2011
    ..Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD)...
  76. ncbi Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling
    James D Ramsden
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Endocrinology 146:2895-902. 2005
    ..Recombinant adenovirus vectors (RAds) expressing truncated, secreted forms of human Tie2 (RAd-sTie2) and vascular endothelial growth factor receptor 1 (RAd-sVEGFR1) or a truncated, dominant-negative fibroblast ..
  77. ncbi A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease
    A E Parker
    Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Biol Chem 273:18332-9. 1998
    In the fission yeast Schizosaccharomyces pombe the rad1(+) gene is required for both the DNA damage-dependent and the DNA replication-dependent cell cycle checkpoints. We have identified a human homologue of the S...
  78. pmc The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
    Magali Toueille
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich Irchel, Wintherturerstrasse 190, CH 8057, Zurich, Switzerland
    Nucleic Acids Res 32:3316-24. 2004
    ..This requires the action of DNA damage sensors such as the Rad family proteins. The three human proteins Rad9, Rad1 and Hus1 form a heterotrimeric complex (called the 9-1-1 complex) that is recruited onto DNA upon damage...
  79. ncbi Analysis of immunogenicity of minor envelope protein GP3 of porcine reproductive and respiratory syndrome virus in mice
    Wenming Jiang
    Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing 210095, China
    Virus Genes 35:695-704. 2007
    ..In this study, two recombinant adenoviruses, rAd-GP3 expressing complete GP3 and rAd-tGP3 expressing truncated GP3 in which aa2-64 were deleted, were constructed ..
  80. doi Antitumor effects of murine bone marrow-derived dendritic cells infected with xenogeneic livin alpha recombinant adenoviral vectors against Lewis lung carcinoma
    Junping Xie
    Department of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Lung Cancer 68:338-45. 2010
    Transduction with recombinant, replication-defective adenoviral (rAd) vectors encoding a transgene is an efficient method for gene transfer into dendritic cells (DCs). Livin is a member of the inhibitor of apoptosis protein family...
  81. ncbi High-performance liquid chromatographic determination of dietary fibre in raw and processed carrots
    A Redondo
    , Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    J Chromatogr A 677:273-8. 1994
    ..414 M H2SO4 for 3 h at 100 degrees C. For the neutralization step prior to injection, AG4-X4 resin (Bio-Rad) was used. Neutral monosaccharides were separated using an HPX-87P column (Bio-Rad)...
  82. ncbi Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. I. Detection systems based on labelled ligands
    A J Oosterkamp
    Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    J Chromatogr A 787:27-35. 1997
    ..Using a recently developed LC-receptor affinity detection (RAD) system as a model, equations are derived which describe the detector response and the signal-to-noise ratio as a ..
  83. ncbi Polarography of Walker tumor submitted to radiotherapy
    M Sakate
    Universidade Estadual Paulista, UNESP, Campus de Botucatu Faculdade de Medicina, Departamento de Radioterapia
    Tumori 73:555-8. 1987
    ..Tumor growth caused a decrease in tumoral oxygen. Oxygen was always lower in the tumor than in the muscle. Radiotherapy with 2000 rad (but not with 1000 rad) increased oxygen in the tumor.
  84. pmc The Arabidopsis UVH1 gene is a homolog of the yeast repair endonuclease RAD1
    A L Fidantsef
    Section of Plant Biology, University of California, Davis, California 95616, USA
    Plant Physiol 124:579-86. 2000
    ..the Arabidopsis uvh1 dark repair mutant with the Arabidopsis homolog of the yeast nucleotide excision repair gene RAD1, which encodes one of the subunits of the 5'-repair endonuclease...
  85. ncbi A comparison of microarray databases
    M Gardiner-Garden
    Entigen Pty Ltd, Eveleigh NSW, Australia
    Brief Bioinform 2:143-58. 2001
    ..BioDiscovery), GEO (NCBI), GXD (Jackson Laboratory), mAdb (NCI), maxdSQL (University of Manchester), NOMAD (UCSF), RAD (University of Pennsylvania) and SMD (Stanford University)...
  86. ncbi Disentangling alpha from beta mechanical relaxations in the rubber-to-glass transition of high-sugar-chitosan mixtures
    Stefan Kasapis
    Department of Food Science and Nutrition, College of Agriculture, Sultan Qaboos University, PO Box 34, Al Khod 123, Sultanate of Oman
    Carbohydr Res 337:595-605. 2002
    ..1 and 100 rad s(-1) in the temperature range from -55 to 50 degrees C...
  87. ncbi Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions
    Stephen N White
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    Mamm Genome 14:149-55. 2003
    ..We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr)..
  88. ncbi Light scattering on oceanic turbulence
    Darek J Bogucki
    Rosenstiel School of Marine and Atmospheric Science, Division of Applied Marine Physics, University of Miami, 4600 Rickenbacker Causeway, Miami, Florida 33149 1098, USA
    Appl Opt 43:5662-8. 2004
    ..Here we report measurements of the volume-scattering function in the range of 10(-7) to 10(-3) rad using a wave-front sensing technique...
  89. ncbi Image-based carotid flow reconstruction: a comparison between MRI and ultrasound
    F P Glor
    Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Physiol Meas 25:1495-509. 2004
    ..411 N m(-2); OSI: 0.048; temporal WSSG: 150 N s(-1) m(-2); spatial WSSG: 2.29 N m(-3); WSSAG: 87.6 rad m(-1))...
  90. ncbi Dynamic cerebral autoregulation during brain activation paradigms
    Ronney B Panerai
    Department of Cardiovascular Sciences, Faculty of Medicine, University of Leicester, Leicester LE1 5WW, UK
    Am J Physiol Heart Circ Physiol 289:H1202-8. 2005
    ..04 +/- 1.01 vs. 0.80 +/- 0.86 rad, P < 0.01) and left (0.11 +/- 0.81 vs. 0.57 +/- 0.51 rad, P < 0...
  91. ncbi Dynamic response of the brain with vasculature: a three-dimensional computational study
    Johnson Ho
    Royal Institute of Technology, School of Technology in Health, Division of Neuronic Engineering, Stockholm, Sweden
    J Biomech 40:3006-12. 2007
    ..In this study, short duration rotational (10,000 rad/s(2) with a duration of 5 ms) and translational (100G with a duration of 5 ms) acceleration impulses were applied ..
  92. doi Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet
    Yasmina Abdiche
    Rinat Laboratories, Pfizer Inc, South San Francisco, CA 94080, USA
    Anal Biochem 377:209-17. 2008
    ..against a panel of peptides to compare the Octet directly with Biacore's well-established 3000 platform and Bio-Rad's recently launched ProteOn XPR36 array system, which use surface plasmon resonance (SPR) to detect the binding of ..
  93. doi Quantitative analysis of facial paralysis using local binary patterns in biomedical videos
    Shu He
    Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow G1 1XQ, UK
    IEEE Trans Biomed Eng 56:1864-70. 2009
    ..The symmetry of facial movements is measured by the resistor-average distance (RAD) between LBP features extracted from the two sides of the face...
  94. ncbi Slot-waveguide cavities for optical quantum information applications
    Mark P Hiscocks
    School of EE and T, UNSW, Sydney, NSW 2052, Australia
    Opt Express 17:7295-303. 2009
    ..We show that one can achieve increased single-photon Rabi frequencies of order O(10(11)) rad s(-1) in ultra-small cavity modal volumes, nearly 2 orders of magnitude smaller than previously studied diamond-..
  95. ncbi Effect of Valsalva maneuver on pulse wave velocity
    K Singh
    Department of Physiology, Postgraduate Institute of Medical Sciences, University of Health Sciences Rohtak, Rohtak
    Indian J Physiol Pharmacol 54:164-8. 2010
    ..001) in phase II rather than phase IV from baseline with insignificant variation in aorta to radial (AO-Rad) arterial segment, demonstrate different response of arterial segments to VM.
  96. pmc Rapid aneuploidy detection or karyotyping? Ethical reflection
    Antina de Jong
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, GROW, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Hum Genet 19:1020-5. 2011
    ..women at increased risk for trisomy 21, 13, and 18 should be offered stand-alone rapid aneuploidy detection (RAD) or karyotyping. In this paper, the ethical implications of a fast, relatively cheap and targeted RAD are examined...
  97. doi Coherent phase lock of a 9 μm quantum cascade laser to a 2 μm thulium optical frequency comb
    Andrew A Mills
    IMRA America Inc, 1044 Woodridge Avenue, Ann Arbor, Michigan 48105, USA
    Opt Lett 37:4083-5. 2012
    ..1 μm to a Tm-fiber laser frequency comb centered at 2 μm, with an integrated residual phase error of 0.9 rad (30 mHz to 1.5 MHz)...
  98. doi Angular orientation of nanorods using nanophotonic tweezers
    Pilgyu Kang
    Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, United States
    Nano Lett 12:6400-7. 2012
    ..An angular trap stiffness of κ = 92.8 pN·nm/rad(2)·mW is demonstrated for the microtubules, and a torsional spring constant of 22...
  99. pmc Microdomains shift and rotate in the lateral wall of cochlear outer hair cells
    Rei Kitani
    Division of Cell Biology and Genetics, House Research Institute, Los Angeles, California, USA
    Biophys J 104:8-18. 2013
    ..direction from random to parallel to the longitudinal axis of the cells with peak reorientation speeds of up to 6 rad/s and returning to random after 5 min without stimulation...
  100. doi Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells
    Henghu Fang
    Department of Radiation Oncology, Navy General Hospital, Beijing, P R China
    Oncol Rep 34:763-70. 2015
    ..adenoviral vector expressing the RPL23 gene under control of the carcinoembryonic antigen (CEA) promoter (rAd/CEA-RPL23), and using an in vitro system with cultured human colorectal carcinoma LoVo cells harboring the wt-p53 ..
  101. ncbi Surface imaging, laser positioning or volumetric imaging for breast cancer with nodal involvement treated by helical TomoTherapy
    Frederik Crop
    Centre Oscar Lambret and Université Lille
    J Appl Clin Med Phys 17:6041. 2016
    A surface imaging system, Catalyst (C-Rad), was compared with laser-based positioning and daily mega voltage computed tomography (MVCT) setup for breast patients with nodal involvement treated by helical TomoTherapy...

Research Grants63

  1. Lauren Endres; Fiscal Year: 2014
    ..e., for SSBR, PARP, XRCC1 and polynucleotide kinase;for DSBR, RAD family proteins, XRCC2 and 3, BRCA1 and 2, Ku70 and 86, and DNAPK)...
  2. RGK proteins and aging muscle
    ROGER ALAN BANNISTER; Fiscal Year: 2012
    ..Members of the RGK (Rad, Rem, Rem2, Gem/Kir) family of monomeric G proteins have been demonstrated to reduce L- type channel membrane ..
  3. Michael J Smerdon; Fiscal Year: 2014
    ..Pol II genes and ribosomal RNA genes (Pol I) of lrs mutants of repair proficient (wt) and repair deficient (rad) cells...
  4. Matthew J O'Connell; Fiscal Year: 2015
    ..Moreover, the same collection of rad mutants includes the cohesin gene rad21...
  5. Variable Dose Rate X-ray Irradiator
    Howard B Lieberman; Fiscal Year: 2010
    ..In this proposal, we request consideration for the funds needed to purchase a X-RAD 320 Biological Irradiator, a variable dose rate x-ray emitter...
  6. Repair of Oxidatively Damaged Guanines
    A LIEN L LU-CHANG; Fiscal Year: 2013
    ..interacts with the DNA replication machinery, other repair enzymes, the 9-1-1 cell cycle checkpoint complex (Rad9/Rad1/Hus1), and the aging regulator SIRT6...
  7. Anja Katrin Bielinsky; Fiscal Year: 2016
    ..to eliciting an S phase checkpoint response through the binding of the hetero-trimeric checkpoint clamp 9-1-1 (Rad9/Rad1/Hus1 in S. pombe and mammals and Ddc1/Rad17/Mec3 in S. cerevisiae)...
  8. Cooperative roles for Atm and Hus1 in genome maintenance
    Robert Weiss; Fiscal Year: 2009
    ..is incompletely understood in part because components of the Atr pathway, which also includes Chk1 and the Rad9-Rad1-Hus1 (911) complex, are essential for viability...
  9. TRANSCRIPTION COFACTORS IN DIFFERENTIATION
    Yang Shi; Fiscal Year: 2011
    ..mutants display increased, p53-dependent germ cell apoptosis, suggesting activation of a DNA damage checkpoint;2) RAD-51 foci levels are elevated during meiotic prophase in spr-5 mutants suggesting that progression of double-strand ..
  10. Temporal and Spatial Relationships of Proteins in Yeast NER
    PAULA FISCHHABER; Fiscal Year: 2009
    ..are required prior to participation of the downstream protein Radio;and (3) whether key amino acid residues of the Rad1 protein are required for recruitment of the Rad1/Radio complex to an NER site...
  11. Mark Lim; Fiscal Year: 2014
    ..Illumina in order to implement clinical multipanel assays on its VeraCodeTM system, as well as with INOVA and Bio-Rad Diagnostics, two leaders in development of clinical immunoassays (see letters)...
  12. Analysis of a DNA Damage-Inducible Checkpoint Complex
    Larry Karnitz; Fiscal Year: 2009
    ..A key node in the regulation of both responses is the Rad9-Hus1-Rad1 (911) complex...
  13. Sang Eun Lee; Fiscal Year: 2016
    ..Removal of a 3'flap also depends on the structure specific endonuclease complex, Rad1/Rad10, and dictates cellular tolerance to cancer chemotherapeutic agents, gene targeting, telomere integrity, ..
  14. RGK GTPases/Ca2+ Channel Cross Talk
    Henry M Colecraft; Fiscal Year: 2010
    ..recently discovered crosstalk between two protein families: high-voltage-activated Ca2+ (CaV) channels and the Rem/Rad/Gem/Kir (RGK) family of Ras-like GTPases...
  15. MEETHA M MEDHORA; Fiscal Year: 2016
    ..We have organized an efficient as well as responsive research plan, team of experts and well trained personnel to meet our goals. ..
  16. Chromatin remodeling specific interactions of ATM
    Sundaresan Venkatachalam; Fiscal Year: 2009
    ..variety of responses that are initiated by the ataxia- telangiectasia mutated (ATM) and ataxia- telangiectasia and Rad 3-related (ATR) kinases...
  17. Validity of Reactive Attachment Disorder
    Brian Stafford; Fiscal Year: 2002
    ..a plan to pilot a preliminary investigation toward the validation of the diagnosis of Reactive Attachment Disorder (RAD). Validation of child psychiatric disorders in general, and disorders in early childhood in particular, are few...
  18. A Role of Osteoimmunology in Leptin-Regulated Bone Metabolism
    ERICA LYNN SCHELLER; Fiscal Year: 2010
    ..differentiation-regulating cytokines through the use of bead-based multichannel ELISA, marketed as BioPlex by Bio-Rad. Differentiation of BMSCs will also be monitored in the presence of control or stimulated macrophages and their ..
  19. Enhanced Propagation of Adult Human Renal Epithelial Cells
    Angela Westover; Fiscal Year: 2009
    ..A hollow fiber based renal assist device (RAD) containing human cells has been evaluated in FDA-approved Phase I/II and Phase II clinical trials...
  20. Adaptive Evolutionary Responses of White-footed Mice (Peromyscus leucopus) to Urb
    Jason Munshi-South; Fiscal Year: 2012
    ..using the SOLiD exome data, and potential regulatory changes outside of protein-coding regions using a genome-wide RAD-Seq (restriction site associated DNA sequencing) approach...
  21. Genomic Analyses of Intraspecific Patterns of Extreme Recombination in Honey Bees
    Olav Rueppell; Fiscal Year: 2012
    ..Construction of the first high-density linkage map for A. mellifera with cost-effective RAD-tag markers to study the fine-scale patterns of recombination and characterize recombinational hotspots. 2...
  22. Anup K Singh; Fiscal Year: 2015
    ..Our goal is to develop, with our commercial partners Invetech and Bio-Rad, a manufacturable and commercializable device (SpinDx) in preparation for 510(k) submission to the FDA...
  23. William G Dunphy; Fiscal Year: 2016
    ..Moreover, the association of TopBP1 with the checkpoint clamp comprised of Rad9-Hus1-Rad1 (the 9-1-1 complex) regulates the interaction of TopBP1 with ATR- ATRIP...
  24. Exposure to Traffic-Related Air Pollution and to Disability in Older Adults
    Jennifer Weuve; Fiscal Year: 2013
    ..exposures to traffic-related air pollution by estimating participants'residential distance to nearest busy rad (DTR;incl...
  25. Codrugs of Lipoic Acid and Tocopherol/Tocopheramine for Use as Photoprotective Ag
    Martha A Hass; Fiscal Year: 2011
    ..1. MacKie, R.M. Effects of ultraviolet radiation on human health. Rad. Protect. Dos. 91 (1-3) 15-18, 2000. 2. Krutman, J...
  26. Reducing Asthma Disparities: The Baltimore City Healthy Homes Initiative
    Madeleine A Shea; Fiscal Year: 2010
    ..by applicant): Project Summary/Abstract "Reducing Asthma Disparities: The Baltimore City Healthy Homes Initiative" (RAD) will reduce racial disparities in asthma morbidity in Baltimore by providing an evidence- based healthy homes ..
  27. BioPlex 200 System with High Throughput Fluidics (HTF) Multiplex Array System
    Christie M Orschell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This proposal is for the purchase of a Bio-Rad Bio-Plex 200 Multiplex Array System with high throughput fluidics...
  28. Rapid and cost-efficient genotyping tools for stuides of threespine stickleback
    William A Cresko; Fiscal Year: 2010
    ..The high-throughput genotyping system that we have developed, RAD mapping, will enable the rapid identification of the genes controlling complex traits ranging from behavior to bone ..
  29. Role of Neurogenesis in Depression and Antidepressant Efficacy
    Jennifer Onksen; Fiscal Year: 2010
    ..Preliminary data indicates that conditional deletion of ataxia-telangeictasia and rad-3 related (ATR), a cell cycle checkpoint kinase, from the hippocampus of the adult mouse, leads to decreased cell ..
  30. GRACE KUBIN; Fiscal Year: 2014
    ..4) participate with the other FERN RAD CAP Labs to coordinate two interlaboratory-comparison emergency response exercises, one in 2012 and the other in ..
  31. EFFECTS OF GAMMA RADIATION ON BIOMEDICAL POLYMERS
    Cato Laurencin; Fiscal Year: 1990
    ..of irradiation of polymers has been inadequate since 1) studies have by and large only addressed the use of 4mega-rad levels of gamma irradiation for sterilization purposes, 2) in determining radiation effects, studies have ..
  32. High Throughput Cloning of Mutant C. elegans Loci
    BRUCE A BOWERMAN; Fiscal Year: 2013
    ..approach to Single Nucleotide Polymorphism (SNP) mapping called Restriction-site Associated DNA polymorphism (RAD) mapping...
  33. BORIS DOMINIK JUELG; Fiscal Year: 2016
    ..The following specific aims will be addressed: 1) Define the antiviral signature(s) of rAd and CMV-vector induced CD4+ and CD8+ T cells associated with protection in rhesus monkeys;2) Determine antiviral ..
  34. Novel Heterologous Adenovirus Prime-Boost HIV-1 Vaccine
    Dan H Barouch; Fiscal Year: 2012
    ..To overcome this problem, we have constructed a series of novel serotype and novel chimeric rAd vectors that effectively circumvent anti-Ad5 immunity...
  35. Purchase and installation of X-Rad 320 Biological irradiator for USC Keck School
    Colin K Hill; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In this application we are requesting funds to purchase and install an X-RAD 320 Biological Irradiator for the University of Southern California Keck School of Medicine...
  36. OLYMPUS FV1000 INVERTED SPECTRAL CONFOCAL SYSTEM
    John A Mercer; Fiscal Year: 2010
    ..The McLaughlin Research Institute last acquired a confocal unit (Bio-Rad MicroRadiance) twelve years ago...
  37. Purchase of confocal microscope
    GLADYS N TEITELMAN; Fiscal Year: 2010
    ..We propose to acquire a Leica TCS SP5 laser scanning confocal system to replace the existing Bio-Rad confocal microscope, currently maintained by Zeiss imaging...
  38. Wenyuan Shi; Fiscal Year: 2015
    ..Based on these findings, we developed our working hypothesis that "Fn interacts via RadD and associated Rad-proteins with early colonizing partner species, which triggers significant morphological and physiological changes ..
  39. Development of CMOS Based Large Format X-ray Detector for Protein Crystallography
    Edwin M Westbrook; Fiscal Year: 2011
    ..We have based this effort on an existing CMOS imaging system for X rays, manufactured by Rad-icon Imaging Corporation...
  40. Jeffrey R Powell; Fiscal Year: 2016
    ..mascarensis. This was done using a technique that is efficient in identifying SNPs (RAD-tags), but this methodology is not applicable for routine genotyping...
  41. Motivated Learning and Memory Neuroimaging Data Repository
    Kevin S LaBar; Fiscal Year: 2013
    ..parent grant will be shared and linked to another public repository of resting state data in addictive disorders (RAD)...
  42. LAMONT BYRD; Fiscal Year: 2014
    ..The training provides workers with the ability to react to an unexpected release of hazmat and rad waste, take appropriate actions, and limit the contamination of surrounding communities and the environment...
  43. Realistic Accurate Dosimulation (RAD)
    HANS GREGORY SCHANTZ; Fiscal Year: 2013
    ..These "Realistic, Accurate Dosimulation" (RAD) tools will be the centerpiece for an effective Emergency Responder radiation training curriculum...
  44. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..double-blinded clinical trial including patients from the UW-Madison is underway to see if a form of rapamycin (RAD) can prevent bronchiolitis obliterans syndrome (BOS) while improving long-term outcome in lung transplants...
  45. LASER PHOTOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Dan Castro; Fiscal Year: 1992
    ..The "LAD" (laser absorptive dose) parallel to the RAD in radiology will be determined. 2...
  46. EXCISION REPAIR OF UV IRRADIATED DNA IN YEAST
    Satya Prakash; Fiscal Year: 2001
    ..This proposal focuses on five excision repair genes: RAD1, RAD2, RAD3, RAD4, and RAD10, and their encoded proteins...
  47. NAPRTCS CLINICAL TRIALS IN PRIMARY & REPEAT TRANSPLANTS
    William Harmon; Fiscal Year: 2002
    ..trial (ratio 2:1) of 600 primary transplant recipients to test the 1st hypothesis, that patients randomized to RAD, cyclosporine (CSA) and prednisone (P) (test arm) will have significantly less acute rejections in the first six ..
  48. X-RAD 225Cx Image Guided Biological Irradiator System
    Timothy Solberg; Fiscal Year: 2010
    ..The instrument we are seeking is uniquely suited to fulfill these requirements. ..
  49. Brain Motion During Blunt Impact
    Albert King; Fiscal Year: 2007
    ..However, the range of angular velocities used was limited to approximately 25 rad/s...
  50. LASER SCANNING CONFOCAL MICROSCOPE
    Peter Gillespie; Fiscal Year: 2009
    ..to purchase an Olympus Fluoview 1000 single-point scanning confocal system, which will replace a 10-year-old Bio-Rad MRC 1024 at the Oregon Hearing Research Center (OHRC)...
  51. CROSS-RESISTANCE OR SENSITIVITY IN MULTIMODAL THERAPY
    WILLIAM LOONEY; Fiscal Year: 1990
    ..A cure rate of 50% was achieved with 6000 rad intermittent MFD alternated with CP contrasted with 11,250 rad with daily radiation fractions and CP...
  52. NOVEL E1 CELL LINE FOR RCA-FREE ADENOVIRAL GENE THERAPY
    Richard Peluso; Fiscal Year: 2001
    ..Commercial production of rAd is limited by replication competent adenovirus (RCA) present in 40-60 percent of rAd lots...
  53. PROTEOMEWORKSTM SYSTEM
    Richard Cook; Fiscal Year: 2001
    This Shared Instrumentation Grant proposal is for the purchase of the ProteomeWorks(TM) System from BIO-RAD and Micromass...
  54. BIO-RAD CONFOCAL MICROSCOPE & 3-D ANALYSIS WORK STATION
    Theresa Harrison; Fiscal Year: 1991
    ..Thomas Rosenquist, who is conducting research at a confocal facility at Univ. of South Carolina, will provide expertise and assistance to the other users and technical support in setting up the facility...
  55. COMMUNITY-BASED PHARMACEUTICAL CARE: A CONTROLLED TRIAL
    Morris Weinberger; Fiscal Year: 1999
    DESCRIPTION: (taken from abstract). Using reactive airways disease (RAD) as a model, the applicants propose to develop algorithms, materials, and an educational program to facilitate pharmaceutical care...
  56. TRANSFORMATION IN VITRO WITH SPLIT DOSES OF RADIATION
    Richard Miller; Fiscal Year: 1980
    ..Experiments with x-rays indicate that at low dose levels below 100 rad, splitting the dose into two fractions separated by a time interval of 5 hours increases the incidence of ..
  57. CONFOCAL SCANNING MICROSCOPE SYSTEM
    WILLIAM ELDRED; Fiscal Year: 1999
    We are requesting the purchase of a Bio-Rad MicroRadiance Confocal Imaging System to be shared by NIH-funded researchers in several departments at the Charles River Campus of Boston University...
  58. REPAIR AND RECOMBINATION IN RADIATION SENSITIVE CELLS
    Rodney Nairn; Fiscal Year: 2003
    ..Many mutant alleles of these RAD genes show affects on DNA repair, recombination, and mutagenesis...
  59. Ultraspec III TOF/TOF 200 MALDI-TOF Mass Spectrometry Imaging System
    Djuro Josic; Fiscal Year: 2009
    ..The second one is the Ciphergen/Bio-Rad SELDI-TOF system, which is used for protein profiling in biomarker discovery...
  60. BioRad Galactomannan EIA for Diagnosis of Aspergillosis
    Kieren Marr; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): The Bio-Rad galactomannan enzyme immunoassay (GM EIA) will soon be submitted to the FDA for approval as an aid to diagnose aspergillosis, a frequent cause of infectious death in immunosuppressed ..
  61. SYNERGISTIC METHIONINASE GENE THERAPY OF CANCER
    Yuying Tan; Fiscal Year: 2000
    ..To achieve this goal, an adenoviral vector of the METase gene has been constructed (rAd-MBTase)...
  62. Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy
    Shuvo Roy; Fiscal Year: 2009
    ..The extracorporeal Renal Assist Device (RAD), which is in Phase II clinical trials, is a large bioartificial kidney that combines hemofiltration with proximal ..