RON

Summary

Gene Symbol: RON
Description: macrophage stimulating 1 receptor
Alias: CD136, CDw136, NPCA3, PTK8, RON, macrophage-stimulating protein receptor, MSP receptor, PTK8 protein tyrosine kinase 8, c-met-related tyrosine kinase, p185-Ron
Species: human

Top Publications

  1. ncbi RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS
    Eileen S Lee
    Graduate Program in Biochemistry, Department of Veterinary Science, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 173:6864-72. 2004
  2. ncbi Identification of the ron gene product as the receptor for the human macrophage stimulating protein
    M H Wang
    Immunopathology Section, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Science 266:117-9. 1994
  3. pmc RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
    G Gaudino
    Department of Biomedical Sciences and Oncology, University of Torino Medical School, Italy
    EMBO J 13:3524-32. 1994
  4. ncbi A novel putative receptor protein tyrosine kinase of the met family
    C Ronsin
    INSERM U211, Institut de Biologie, Nantes, France
    Oncogene 8:1195-202. 1993
  5. ncbi Interplay between scatter factor receptors and B plexins controls invasive growth
    Paolo Conrotto
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    Oncogene 23:5131-7. 2004
  6. ncbi Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase
    Xin Wei
    Graduate Program in Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
    J Biol Chem 280:35098-107. 2005
  7. pmc Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON
    Dahis Manzanares
    Division of Pulmonary and Critical Care Medicine, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 7063A R 47, Miami, FL 33136, USA
    Am J Respir Cell Mol Biol 37:160-8. 2007
  8. ncbi The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
    Ryan M Thomas
    Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cancer Res 67:6075-82. 2007
  9. doi Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility
    Kun Zhang
    Laboratory of Cancer Biology and Therapeutics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People s Republic of China
    Carcinogenesis 29:552-9. 2008
  10. doi RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant
    Carmen Eckerich
    Department of Neurosurgery, Laboratory for Brain Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    J Neurochem 109:969-80. 2009

Research Grants

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
  2. Susan E Waltz; Fiscal Year: 2016
  3. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
  4. Joseph W Harding; Fiscal Year: 2014
  5. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
  6. Jing Wang; Fiscal Year: 2014
  7. Ken A Paller; Fiscal Year: 2015
  8. LIVER REGENERATION AND GROWTH FACTORS
    SANDRA DEGEN; Fiscal Year: 2000
  9. Drosophila tracheal cytonemes in long range FGF signaling
    Sougata Roy; Fiscal Year: 2013
  10. JOE ROBERT NOCERA; Fiscal Year: 2015

Detail Information

Publications206 found, 100 shown here

  1. ncbi RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS
    Eileen S Lee
    Graduate Program in Biochemistry, Department of Veterinary Science, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 173:6864-72. 2004
    ..We have focused on the receptor tyrosine kinase RON, a critical negative regulator of macrophage function and inflammation, to determine whether this receptor ..
  2. ncbi Identification of the ron gene product as the receptor for the human macrophage stimulating protein
    M H Wang
    Immunopathology Section, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Science 266:117-9. 1994
    ..Labeled MSP bound to Madin-Darby canine kidney (MDCK) cells transfected with complementary DNA encoding Ron, a cell membrane protein tyrosine kinase...
  3. pmc RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
    G Gaudino
    Department of Biomedical Sciences and Oncology, University of Torino Medical School, Italy
    EMBO J 13:3524-32. 1994
    b>RON, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. Here we show that the RON gene is expressed in several epithelial tissues as well as in granulocytes and monocytes...
  4. ncbi A novel putative receptor protein tyrosine kinase of the met family
    C Ronsin
    INSERM U211, Institut de Biologie, Nantes, France
    Oncogene 8:1195-202. 1993
    ..and from human foreskin keratinocytes, we have isolated overlapping cDNAs coding for a novel protein which we call Ron, with sequence characteristics of a receptor protein tyrosine kinase...
  5. ncbi Interplay between scatter factor receptors and B plexins controls invasive growth
    Paolo Conrotto
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    Oncogene 23:5131-7. 2004
    Met and Ron tyrosine kinases are members of the Scatter Factor Receptor family. Met is the receptor for hepatocyte growth factor while Ron is that for macrophage stimulating protein...
  6. ncbi Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase
    Xin Wei
    Graduate Program in Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
    J Biol Chem 280:35098-107. 2005
    ..We have shown that the murine Ron (mRon) receptor tyrosine kinase exhibits constitutive activation of the MAP kinase pathway that is independent of ..
  7. pmc Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON
    Dahis Manzanares
    Division of Pulmonary and Critical Care Medicine, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 7063A R 47, Miami, FL 33136, USA
    Am J Respir Cell Mol Biol 37:160-8. 2007
    ..transmembrane domain and thus cannot signal on its own, the association of RHAMM with recepteur d'origine nantais (RON), a member of the hepatocyte growth factor receptor family, was explored...
  8. ncbi The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
    Ryan M Thomas
    Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Cancer Res 67:6075-82. 2007
    ..The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed and/or constitutively active in several epithelial cancers, but its role ..
  9. doi Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility
    Kun Zhang
    Laboratory of Cancer Biology and Therapeutics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People s Republic of China
    Carcinogenesis 29:552-9. 2008
    ..We report here that activation of recepteur d'origine nantais (RON) differentially regulates tight junction function and claudin expression...
  10. doi RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant
    Carmen Eckerich
    Department of Neurosurgery, Laboratory for Brain Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    J Neurochem 109:969-80. 2009
    ..The recepteur d'origine nantais (RON) receptor tyrosine kinase is highly expressed in several epithelial cancer types and mediates tumorigenic, pro-..
  11. pmc The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells
    M N Thobe
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Oncogene 29:214-26. 2010
    Overexpression of the Ron receptor tyrosine kinase has recently been shown in a wide variety of human cancers. However, no studies have examined Ron receptor expression or function during prostate tumorigenesis...
  12. pmc Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers
    Jocelyn Logan-Collins
    Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Ohio, USA
    Cancer Res 70:1130-40. 2010
    The RON receptor tyrosine kinase is overexpressed in premalignant pancreatic intraepithelial neoplasia (PanIN) and in the majority of pancreatic cancers...
  13. pmc An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells
    Hsiao Sheng Liu
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    Carcinogenesis 31:1456-64. 2010
    Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways...
  14. pmc RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma
    Daniel V T Catenacci
    University of Chicago, USA
    Cancer Biol Ther 12:9-46. 2011
    b>RON (MST1R) is one of two members of the MET receptor tyrosine kinase family, along with parent receptor MET...
  15. pmc Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution
    Natalia Gorlatova
    Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, United States of America
    PLoS ONE 6:e27269. 2011
    ..MSP binding to the RON receptor tyrosine kinase activates signaling pathways involved in the inflammatory response...
  16. pmc A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype
    C Collesi
    Institute for Cancer Research, University of Turin Medical School, Italy
    Mol Cell Biol 16:5518-26. 1996
    The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering)...
  17. ncbi Cross-talk between the proto-oncogenes Met and Ron
    A Follenzi
    Institute for Cancer Research and Treatment IRCC, University of Torino, School of Medicine 10060, Candiolo, Italy
    Oncogene 19:3041-9. 2000
    ..factor 1) and MSP (Scatter Factor 2) bind to tyrosine kinase receptors encoded by the proto-oncogenes MET and RON. Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in ..
  18. ncbi Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential
    Yong Qing Zhou
    Division of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Oncogene 22:186-97. 2003
    The RON receptor tyrosine kinase is a member of the MET proto-oncogene family that has been implicated in regulating motile-invasive phenotypes in certain types of epithelial cancers...
  19. pmc Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus
    Alla Danilkovitch-Miagkova
    Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:4580-5. 2003
    ..Here we show that the HYAL2 receptor protein is associated with the RON receptor tyrosine kinase (also called MST1R or Stk in the mouse), rendering it functionally silent...
  20. ncbi c-Cbl is a critical modulator of the Ron tyrosine kinase receptor
    Lorenza Penengo
    Department of Medical Sciences, University of Piemonte Orientale, Novara 28100, Italy
    Oncogene 22:3669-79. 2003
    b>Ron, the receptor tyrosine kinase (RTK) for the macrophage stimulating protein (MSP), activates multiple signaling pathways by recruiting several positive regulators to a multifunctional docking site...
  21. ncbi The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration
    Massimo M Santoro
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, 28100, Novara, Italy
    Dev Cell 5:257-71. 2003
    ..We show that growth factor macrophage stimulating protein (MSP)- and its receptor Ron-mediated PI3K activation in keratinocytes induces phosphorylation of both Ron and alpha6beta4 integrin at specific ..
  22. ncbi RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells
    Xiang Ming Xu
    Laboratory of Cheung Kong Scholars Program for Biomedical Sciences, Institute of Infectious Diseases, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, PR China
    Oncogene 23:8464-74. 2004
    ..In this study, the pathogenic roles of receptor tyrosine kinase RON (recepteur d'origine nantais) in regulating oncogenic phenotypes in colorectal epithelial cells were studied...
  23. ncbi Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients
    Wen Ying Lee
    Department of Pathology, College of Medicine, National Cheng Kung University, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan 710, Taiwan
    Clin Cancer Res 11:2222-8. 2005
    b>RON and MET belong to a subfamily of tyrosine kinase receptors. They both can induce invasive growth, including migration, cell dissociation, and matrix invasion...
  24. ncbi Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity
    Xin Wei
    Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:40241-51. 2005
    ..We find that expression of mouse RON, but not human RON, results in constitutive receptor autophosphorylation, ligand-independent activation of the ..
  25. ncbi Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target
    E Ramsay Camp
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:1030-9. 2007
    ..It was hypothesized that RON, a tyrosine kinase receptor related to c-MET, would be expressed in human pancreatic cancer cells, induce EMT, and ..
  26. pmc Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence
    Marceline Côté
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Biochem Biophys Res Commun 360:219-25. 2007
    The RON receptor tyrosine kinase is a member of the MET proto-oncogene family and is important for cell proliferation, differentiation, and cancer development...
  27. pmc Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells
    Shujie Zhao
    Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 283:11293-301. 2008
    ..We show here that loss of Smad4-dependent signaling leads to aberrant expression of RON, a phosphotyrosine kinase receptor, and that signaling by RON cooperates with Smad4-independent TGF-beta signaling ..
  28. pmc Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
    Purnima K Wagh
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Adv Cancer Res 100:1-33. 2008
    The Ron receptor is a member of the Met family of cell surface receptor tyrosine kinases and is primarily expressed on epithelial cells and macrophages...
  29. pmc The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells
    K J Feres
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA
    Oncogene 28:279-88. 2009
    The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor...
  30. pmc Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma
    Jing Wang
    University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Omaha, Nebraska 68198, USA
    J Biol Chem 284:10912-22. 2009
    Abnormal accumulation and activation of receptor tyrosine kinase Ron (recepteur d'origine nantais) has been demonstrated in a variety of primary human cancers...
  31. ncbi Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence
    Qi Ma
    Center for Cancer Biology and Therapeutics, School of Pharmacy, Texas Tech University Health Sciences, Amarillo, TX 79106, USA
    Int J Oncol 36:1551-61. 2010
    The RON receptor tyrosine kinase and its ligand macrophage stimulating protein (MSP) play a role in epithelial tumorigenesis. We report here a novel RON variant that antagonizes the RON-MSP pathway in various cancer cells...
  32. pmc Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines
    Rebecca J McClaine
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neoplasia 12:650-8. 2010
    ..The Ron receptor tyrosine kinase, a member of the c-Met family of receptors, is expressed in a number of human epithelial ..
  33. pmc STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
    A Iwama
    Department of Cell Differentiation, Kumamoto University School of Medicine, Japan
    EMBO J 15:5866-75. 1996
    STK/RON tyrosine kinase, a member of the hepatocyte growth factor (HGF) receptor family, is a receptor for macrophage-stimulating protein (MSP)...
  34. ncbi Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais
    Yi Qing Chen
    Department of Medicine, University of Colorado School of Medicine, CU Cancer Center, and Denver Health Medical Center, Denver, CO 80204, USA
    Carcinogenesis 23:1811-9. 2002
    The receptor tyrosine kinase RON (recepteur d'origine nantais), a member of the MET proto-oncogene family, has been implicated in the pathogenesis of certain epithelial cancers including lung adenocarcinomas...
  35. ncbi The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma
    Teresa Rampino
    Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo University, Milano, Italy
    Am J Surg Pathol 27:779-85. 2003
    The proto-oncogene product Ron is the receptor for macrophage stimulating protein, a scatter factor that stimulates cell proliferation, prevents apoptosis, and induces an invasive cell phenotype...
  36. ncbi Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase
    Da Wang
    Laboratory of Chang Jiang Scholar Endowment for Biomedical Sciences, Institute of Infectious Diseases and First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People s Republic of China
    Oncogene 23:1668-80. 2004
    ..Using recepteur d'origine nantais (RON)-expressing epithelial cells as a model, we showed that RON activation causes spindle-shaped morphology with ..
  37. pmc The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans
    Alana L Welm
    The G W Hooper Foundation, Physics Research Laboratory, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:7570-5. 2007
    ..These data suggest that signaling initiated by MSP is an important contributor to metastasis of breast cancer and introduce an independent biomarker for assessing the prognosis of humans with breast cancer...
  38. ncbi Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain
    Ming hai Wang
    Laboratory of Cheung Kong Scholars Program for Tumor Biology, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, PR China
    Cancer Biol Ther 6:1121-9. 2007
    Altered expression of the RON receptor tyrosine kinase, accompanied by generation of splicing variants, contributes to the pathogenesis of epithelial cancers such as invasive growth of colorectal caners...
  39. ncbi Receptor protein tyrosine kinase Ron is highly expressed in colorectal mucosa of ulcerative colitis patients
    Isao Hirayama
    Gunma Prefectural Cancer Center, Ota, Gunma 373 8550, Japan
    Hepatogastroenterology 54:1672-5. 2007
    ..To identify possible regeneration or proliferation factors in colorectal mucosa of UC patients, we screened receptor-type protein tyrosine kinases in human colorectal mucosa...
  40. doi Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease
    John B Beckly
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Inflamm Bowel Dis 14:500-7. 2008
    ....
  41. ncbi The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity
    Alicia Klatt
    Center of Molecular Immunology and Infectious Diseases, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 180:1670-7. 2008
    ..Previously, it has been shown that the receptor tyrosine kinase RON inhibits HIV transcription...
  42. pmc Expression of the RON receptor tyrosine kinase and its association with gastric carcinoma versus normal gastric tissues
    Donghui Zhou
    Department of Oncology, The First Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou, PR China
    BMC Cancer 8:353. 2008
    Recepteur d'origine nantais (RON) is a receptor tyrosine kinase that is activated by a serum-derived, macrophage stimulating protein (MSP) growth factor and is expressed in many malignant tumors...
  43. ncbi Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotypes in epithelial cells
    Kun Zhang
    Laboratory of Cancer Biology and Therapeutics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, P R China
    Int J Oncol 36:255-64. 2010
    ..This study determined the RON receptor in regulation of motile-invasive phenotypes of epithelial cells. Two RON variants, RON165...
  44. doi MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF-κB signals in gastric cancer cells
    Jung Sun Park
    Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju 501 190, Korea
    Carcinogenesis 32:175-81. 2011
    Overexpression of recepteur d'Origine nantais (RON) and urokinase plasminogen activator receptor (uPAR) have been observed in human gastric cancers. However, the interaction between RON and uPAR in gastric cancer is unclear...
  45. pmc Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase
    Qi Ma
    Laboratory of Cancer Biology in State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P, R, China
    Mol Cancer 9:307. 2010
    Activation of the RON receptor tyrosine kinase, a member of the c-MET family, regulates tumorigenic phenotypes. The RON extracellular domains are critical in regulating these activities...
  46. doi Proteolytic activation of pro-macrophage-stimulating protein by hepsin
    Rajkumar Ganesan
    Department of Early Discovery Biochemistry, Genentech, Inc, 1 DNA Way, MS 27, South San Francisco, CA 94080, USA
    Mol Cancer Res 9:1175-86. 2011
    ..protein (MSP) is a plasminogen-related growth factor and ligand for the receptor tyrosine kinase RON. The MSP/RON system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response...
  47. doi Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells
    Cho Yun Chung
    Department of Internal Medicine, Chonnam National University Medical School, 8 Hak Dong, Dong Ku, Gwangju, 501 757, Korea
    Dig Dis Sci 57:371-80. 2012
    Altered Recepteur d'Origine nantais (RON) expression transduces signals inducting invasive growth phenotype that includes cell proliferation, migration, matrix invasion, and protection of apoptosis in human cancer cells...
  48. ncbi The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
    Piera Maggiora
    Laboratory of Cancer Genetics of the Institute for Cancer Research and Treatment, University of Torino School of Medicine, SP 142, Km 3 95, 10060 Candiolo Torino, Italy
    Exp Cell Res 288:382-9. 2003
    b>RON is a member of the receptor tyrosine kinase gene family that includes the MET oncogene, whose germline mutations have been causally related to human tumorigenesis...
  49. pmc Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor
    Massimo M Santoro
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, Novara, Italy
    Biochem J 376:587-94. 2003
    The tyrosine kinase Ron, receptor for MSP (macrophage-stimulating protein), displays several serine residues of unknown functions...
  50. ncbi The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis
    S Matsuzaki
    Department of Gynecology, Polyclinique de l Hotel Dieu, CHU, Clermont Ferrand, France
    Mol Hum Reprod 11:345-9. 2005
    ..DNA microarray analysis using tissue obtained by laser capture microdissection (LCM) identified up-regulation of RON (a tyrosine kinase receptor) during the late secretory phase in eutopic endometrial epithelial cells from patients ..
  51. ncbi The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation
    Debora Angeloni
    Laboratory of Immunobiology, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Biol Chem 279:3726-32. 2004
    b>RON is a receptor tyrosine kinase of the MET family that is involved in cell proliferation, cell survival, and cell motility in both normal and disease states...
  52. ncbi Case reports: arsenic pollution in Thailand, Bangladesh, and Hungary
    Huw Jones
    Institute of Social and Health Research, School of Health and Social Sciences, Middlesex University, The Burroughs, London NW4 4BT, UK
    Rev Environ Contam Toxicol 197:163-87. 2008
    ..The Ron Phibun region of Thailand has a 100-yr history of tin mining...
  53. ncbi C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3
    Debora Angeloni
    Laboratory of Immunobiology, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mol Cell Probes 17:55-7. 2003
    The MST1R (RON) gene, that maps at 3p21.3, encodes a protein tyrosine kinase receptor comprised of an extra-cellular domain that contains the ligand binding pocket and an intracellular region where the kinase domain is located...
  54. ncbi Arsenic pollution sources
    Hemda Garelick
    Department of Natural Sciences, School of Health and Social Sciences, Middlesex University, The Burroughs, London NW4 4BT, UK
    Rev Environ Contam Toxicol 197:17-60. 2008
    ..Historical arsenic contamination exists in Cornwall, UK; an example of a recent arsenic pollution event is that of Ron Phibun town in southern Thailand, where arsenic-related human health effects have been reported...
  55. ncbi Evaluation of radial optic neurotomy for central retinal vein occlusion by indocyanine green videoangiography and image analysis
    Hiroyuki Nomoto
    Department of Ophthalmology, Kagawa University School of Medicine, Kagawa, Japan
    Am J Ophthalmol 138:612-9. 2004
    To evaluate the effects of radial optic neurotomy (RON) on retinal circulation in patients with central retinal vein occlusion (CRVO) by indocyanine green (ICG) videoangiography and a computer-assisted image analysis.
  56. doi Comparison of the contents of kampo decoctions containing ephedra herb when prepared simply or by re-boiling according to the traditional theory
    Katsuhiro Hayashi
    Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Japan
    J Nat Med 64:70-4. 2010
    ..Shokan-zatsubyo-ron (Shanghan zabing lun in Chinese), a classical textbook of kampo medicine published in 220 A.D...
  57. doi [Circumscribed retinal detachment after radial optic neurotomy for central retinal vein occlusion]
    W F Schrader
    Universitäts Augenklinik Würzburg, Wurzburg, Deutschland
    Ophthalmologe 106:1022-3. 2009
    It has been suggested that radial optic neurotomy (RON) may improve the functional outcome of retinal vein occlusions...
  58. ncbi Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein
    Federico Carafoli
    MRC Centre, Hills Road, Cambridge, UK
    FEBS J 272:5799-807. 2005
    ..beta-chain of human HGFl/MSP, a serine proteinase homology domain containing the high-affinity binding site for the RON receptor. The structure describes at 1...
  59. doi An epidemiological study of neuromyelitis optica in Cuba
    José A Cabrera-Gómez
    International Center of Neurological Restoration, Avenida 25 15805, Cubanacan, Playa, La Habana, Cuba
    J Neurol 256:35-44. 2009
    ..Two population-based studies of neuromyelitis optica (NMO) in non-white populations provided prevalence rates of 0.32 and 3.1 per 100,000 population...
  60. pmc Changes in tumorigenesis- and angiogenesis-related gene transcript abundance profiles in ovarian cancer detected by tailored high density cDNA arrays
    A M Martoglio
    Department of Obstetrics and Gynaecology, University of Cambridge, England
    Mol Med 6:750-65. 2000
    ..Use of cDNA arrays tailored for studies of specific pathways, tissues, or disease states may render a cost- and time-effective method to define potential hallmark genotype alterations...
  61. ncbi Hepatocyte growth factor and macrophage-stimulating protein are upregulated during excisional wound repair in rats
    A J Cowin
    Child Health Research Institute and CRC for Tissue Growth and Repair, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia, 5006, Australia
    Cell Tissue Res 306:239-50. 2001
    ..of cutaneous wounds we have mapped the temporal expression of these two molecules and their receptors, MET and RON respectively, in adult rat excisional wounds...
  62. ncbi Visual field defects after radial optic neurotomy for central retinal vein occlusion
    Adiel Barak
    Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Retina 26:549-54. 2006
    Surgical decompression of the vein in central retinal vein occlusion (CRVO) by radial optic neurotomy (RON) was recently proposed as being surgically feasible, safe, and beneficial...
  63. ncbi Treatment of central retinal vein occlusion by radial optic neurotomy in 107 cases
    H C Hasselbach
    Department of Ophthalmology, University Hospital Schleswig Holstein, Campus Kiel, Hegewischstr 2, 24105 Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1145-56. 2007
    To evaluate the potential role of radial optic neurotomy (RON), a new surgical technique has been recently proposed for treating central retinal vein occlusion (CRVO)...
  64. doi Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo
    Hiroaki Kataoka
    Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    FEBS J 277:2230-7. 2010
    ..in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON. Therefore, the pericellular activity of HGFA might be an important factor regulating the activities of these ..
  65. ncbi Liquid chromatographic multicomponent method for determination of residues of ipronidazole, ronidazole, and dimetridazole and some relevant metabolites in eggs, plasma, and feces and its use in depletion studies in laying hens
    R M Aerts
    State Institute for Quality Control of Agricultural Products, Wageningen, The Netherlands
    J Assoc Off Anal Chem 74:46-55. 1991
    ..has been developed for the determination in eggs of residues of the histomonostats dimetridazole (DMZ), ronidazole (RON), ipronidazole (IPR), and side-chain hydroxylated metabolites of DMZ and RON...
  66. pmc Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin
    S Brunelleschi
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, Via Solaroli, 17 28100 Novara, Italy
    Br J Pharmacol 134:1285-95. 2001
    ..MSP is the ligand for Ron, a member of the Met subfamily of tyrosine kinase receptors...
  67. ncbi Radial optic neurotomy in central retinal vein occlusion: comparison of outcome in younger vs older patients
    Jose Garcia-Arumi
    Hospital Vall d Hebron, Universidad Autonoma de Barcelona, 08022 Barcelona, Spain
    Am J Ophthalmol 143:134-140. 2007
    To evaluate the effectiveness of radial optic neurotomy (RON) for central retinal vein occlusion (CRVO) in patients < or =50 years of age (group 1) vs those >50 (group 2).
  68. pmc PI 3-kinase regulatory subunits as regulators of the unfolded protein response
    Jonathon N Winnay
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 490:147-58. 2011
    ..PKR-like kinase (PERK), inositol requiring 1 α (IRE1α), and activating transcription factor 6α (ATF6α) (Ron, D., and Walter, P. (2007). Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev...
  69. ncbi Regulation of megakaryocytopoiesis and platelet production by tyrosine kinases and tyrosine phosphatases
    H Avraham
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, Massachusetts, 02115
    Methods 17:250-64. 1999
    ..tyrosine kinase receptors important in megakaryocytopoiesis include c-Kit, fibroblast growth factor receptor, the RON receptor, and the macrophage colony-stimulating factor receptor...
  70. ncbi [Radial optic neurotomy in ischemic central retinal vein occlusion]
    R C Lerche
    Klinik und Poliklinik für Augenheilkunde, Universitäts Krankenhaus Hamburg Eppendorf
    Klin Monbl Augenheilkd 222:134-41. 2005
    ..Prognosis is poor and loss of vision is a severe risk. New approaches for treatment like systemic fibrinolysis and surgical procedures have been suggested...
  71. ncbi [Radial optic neurotomy (RON) for central retinal vein occlusion]
    B M Stoffelns
    Augenklinik der Johannes Gutenberg Universität, Mainz, Germany
    Klin Monbl Augenheilkd 224:282-7. 2007
    ..Compression in the lamina cribrosa is discussed as a reason for central retinal vein occlusion. Radial optic neurotomy should release the pressure and increase venous blood outflow...
  72. ncbi Practice guidelines for videoconferencing-based telemental health - october 2009
    Peter Yellowlees
    1 UC Davis Psychiatry, Sacramento, California
    Telemed J E Health 16:1074-89. 2010
    ..MPH [C] Mark Koltek, MD [R] Elizabeth Krupinski, PhD [SG, C] Jonathan Linkous, MPA [S] Liz Loewen, RN, BFA, MN [R] Ron Mazik [R] Dennis Mohatt [R] Kathleen Myers, MD, MPH [Co-Chair, WG] Eve-Lynn Nelson, PhD [Co-Chair, WG] Hon S...
  73. ncbi [Central and branch retinal vein occlusion. Current strategies for treatment in Germany, Austria and Switzerland]
    A E Höh
    Schwerpunkt Retinologie, Universitätsaugenklinik Heidelberg, Heidelber, Germany
    Ophthalmologe 104:290-4. 2007
    ..The main object of this study was to find out what treatment methods are currently preferred for central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) in Germany, Austria and Switzerland...
  74. ncbi Exposure to methyl tert-butyl ether and tert-amyl methyl ether from gasoline during tank lorry loading and its measurement using biological monitoring
    S Vainiotalo
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
    Int Arch Occup Environ Health 71:391-6. 1998
    ..During the field measurements in October 1994 and August 1995 the gasolines (95, 98, 99 RON) contained MTBE to 5.2-11.8% and TAME to 0-6%.
  75. ncbi Residual effects of Mossmann 100 (permethrin 10% EC) impregnated bed nets and its impact on malaria vectors and incidence of malaria
    Narumon Komalamisra
    Insecticide Research Unit, Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 40:229-34. 2009
    ..The study was carried out between July and December 2007 in the Pong Nam Ron District of Chantaburi Province, Thailand...
  76. pmc Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production
    Nikolaos M Nikolaidis
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Shock 33:197-204. 2010
    The Ron receptor tyrosine kinase (TK) plays a regulatory role in the inflammatory response to acute lung injury induced by intranasal administration of bacterial LPS...
  77. doi Ron kinase transphosphorylation sustains MET oncogene addiction
    Silvia Benvenuti
    Exploratory Research Laboratory, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, 10060 Candiolo, Turin, Italy
    Cancer Res 71:1945-55. 2011
    Receptors for the scatter factors HGF and MSP that are encoded by the MET and RON oncogenes are key players in invasive growth. Receptor cross-talk between Met and Ron occurs...
  78. ncbi The potential of Thai indigenous plant species for the phytoremediation of arsenic contaminated land
    P Visoottiviseth
    Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Pollut 118:453-61. 2002
    ..The areas were the Ron Phibun District (Nakorn Si Thammarat province) and Bannang Sata District (Yala province), and samples were taken in ..
  79. ncbi Life cycle assessment of gasoline blending options
    Teresa M Mata
    Laboratory of Processes, Environment and Energy Engineering, Faculty of Engineering, University of Porto, Rua Dr Roberto Frias, 4200 465 Porto, Portugal
    Environ Sci Technol 37:3724-32. 2003
    ..However, different results are obtained for high-octane gasoline (98 RON), where increasing reformer temperatures and pressures increase the reformate octane values faster than the ..
  80. ncbi Vitrectomy and radial optic neurotomy for central retinal vein occlusion: effects on visual acuity and macular anatomy
    H J Zambarakji
    Moorfields Eye Hospital, London, UK
    Graefes Arch Clin Exp Ophthalmol 243:397-405. 2005
    ..The purpose of the study reported here was to evaluate the potential benefit of radial optic neurotomy (RON) and determine its effect on foveal thickness and macular volume in patients with CRVO.
  81. ncbi Differences in cortical activation during smooth pursuit and saccadic eye movements following cerebellar lesions
    O Baumann
    Department of Experimental Psychology, University of Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
    Exp Brain Res 181:237-47. 2007
    ..b>Ron and Robinson (J Neurophysiol 36:1004-1022, 1973) evoked smooth pursuit and saccadic eye movements by electrical ..
  82. ncbi [Radial optic neurotomy for ischemic central retinal vein occlusion]
    A Lommatzsch
    Augenabteilung am St Franziskus Hospital Münster, Hohenzollernring 74, Munster
    Klin Monbl Augenheilkd 224:763-9. 2007
    ..Clinically accepted guidelines for treating CRVO do not exist up to now. In this report our results after radial optic neurotomy (RON) of patients suffering from CRVO associated with visual deterioration are summarised.
  83. ncbi In memoriam: Great 21st century physician 'One Health' leader dies - Ronald M. Davis, MD, Past President, American Medical Association
    Laura H Kahn
    Physician Research Scholar, Program on Science and Global Security, Woodrow Wilson School of Public and International Affairs, Princeton University, 221 Nassau Street, 2nd Floor, Princeton, New Jersey 08542, USA
    Vet Ital 45:209. 2009
    ..Indeed, the AMA wouldn't have passed its historic One Health Resolution without Ron's leadership...
  84. ncbi Nash: genius with schizophrenia or vice versa?
    Tevita Funaki
    Massey University, Auckland
    Pac Health Dialog 15:129-37. 2009
    ..b>Ron Howard directed the movie, A Beautiful Mind based on Nash's biography about his mathematical genius and his ..
  85. ncbi Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives
    Claudia Ghigna
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche IGM CNR, Pavia, Italy
    RNA Biol 7:495-503. 2010
    ..An alternatively spliced isoform of a scatter factor receptor and proto-oncogene, Ron, accumulates during tumor progression of epithelial tissues and is able to confer an invasive phenotype to the ..
  86. pmc Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion
    Sebastien Besteiro
    UMR 5235 CNRS, Université de Montpellier 2, Montpelier, France
    PLoS Pathog 5:e1000309. 2009
    ..We also demonstrated that all RON proteins are present at the MJ during invasion...
  87. ncbi Follow up of water use in a tin mining area affected with arsenic poisoning
    V Chongsuvivatwong
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
    Southeast Asian J Trop Med Public Health 31:769-74. 2000
    b>Ron Phibun district in southern Thailand has been known as an endemic area for arsenic contamination. The government has been trying to improve the situation by encouraging the use of rainwater and piped water...
  88. ncbi Evidence-based practice for telemental health
    Brian Grady
    1 University of Maryland Psychiatry, Baltimore, Maryland
    Telemed J E Health 17:131-48. 2011
    ..MPH [C] Mark Koltek, MD [R] Elizabeth Krupinski, PhD [SG, C] Jonathan Linkous, MPA [S] Liz Loewen, RN, BFA, MN [R] Ron Mazik [R] Dennis Mohatt [R] Kathleen Myers, MD, MPH [Co-Chair, WG] Eve-Lynn Nelson, PhD [Co-Chair, WG] Hon S...
  89. ncbi [Preliminary assessment of Streptococcus pneumoniae, pneumonia, economical and clinical burden in Romania]
    Ioan Paul Stoicescu
    Clinica de Pneumologie, Institutul National Marius Nasta, UMF Carol Davila, Bucuresti
    Pneumologia 56:118-23. 2007
    ..However, the real burden of pneumococcal disease in Romania remains unknown...
  90. ncbi Revised diagnostic criteria for neuromyelitis optica (NMO). Application in a series of suspected patients
    Albert Saiz
    Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, Barcelona, 08036 Spain
    J Neurol 254:1233-7. 2007
    ..diagnosis after follow-up was 16 NMO, 12 MS, 11 transverse myelitis (TM) and seven recurrent optic neuritis (RON). NMO-IgG was detected in 62.5% of NMO, 50% of the recurrent longitudinally extensive TM, 14...
  91. doi Management of arsenic-accumulated waste from constructed wetland treatment of mountain tap-water
    Sannop Nakwanit
    Department of Biology, Faculty of Science, Mahidol University, Rama 6 Road, Rachataewee, Bangkok 10400, Thailand
    J Hazard Mater 185:1081-5. 2011
    Arsenic-contaminated mountain tap water supply in Ron Phibun District, Nakorn Si Thammarat Province, Thailand poses a health hazard...
  92. ncbi Arsenic species in an arsenic hyperaccumulating fern, Pityrogramma calomelanos: a potential phytoremediator of arsenic-contaminated soils
    Kevin Francesconi
    Institute of Biology, University of Southern Denmark, Odense
    Sci Total Environ 284:27-35. 2002
    ..Pityrogramma calomelanos is a hyperaccumulator of arsenic that grows readily on arsenic-contaminated soils in the Ron Phibun district of southern Thailand. P...
  93. pmc Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 45:546-52. 2001
    Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from patients hospitalized in a suburb of Paris, France...
  94. ncbi Spectacular reproduction: Ron's Angels and mechanical reproduction in the age of ART (assisted reproductive technology)
    Valdimar Tr Hafstein
    Department of Anthropology and Folklore, Faculty of Social Sciences, University of Iceland, IS 101 Reykjavik, Iceland
    J Med Humanit 28:3-17. 2007
    b>Ron Harris captured the popular imagination in October 1999 with a website where he auctioned off the ova of fashion models to the highest bidder...
  95. ncbi Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages
    Yong Qing Zhou
    Division of Neurosurgery, The First Affiliated Teaching Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People s Republic of China
    J Biol Chem 277:38104-10. 2002
    The RON receptor tyrosine kinase is activated by macrophage-stimulating protein, which regulates macrophage migration, phagocytosis, and nitric oxide production...
  96. ncbi Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure
    Mike A Leonis
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati, OH 45229, USA
    Hepatology 36:1053-60. 2002
    The targeted deletion of the cytoplasmic domain of the Ron receptor tyrosine kinase (TK) in mice leads to exaggerated responses to injury in several murine models of inflammation as well as increased lethality in response to endotoxin (..
  97. pmc Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2
    A Dusty Miller
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    BMC Cancer 4:64. 2004
    ..transforming activity of JSRV Env depends on activation of the cell-surface receptor tyrosine kinase Mst1r (called RON for the human and Stk for the rodent orthologs)...
  98. pmc Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis
    Charles C Caldwell
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 36:1585-93. 2008
    To determine whether Ron receptor tyrosine kinase signaling affects the in vivo response to bacterial peritonitis.
  99. ncbi [Clinical significance and prognostic value of RON protein expression in gastric carcinoma]
    Dong Hui Zhou
    Department of Oncology, First Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou 310003, China
    Zhonghua Yi Xue Za Zhi 88:1746-9. 2008
    To investigate the protein expression of RON, a tyrosine kinase receptor, protein in gastric carcinoma and the relationship between its expression and prognosis of cancer.
  100. doi Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study
    Tom H Williamson
    Department of Ophthalmology, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Graefes Arch Clin Exp Ophthalmol 247:1019-23. 2009
    ..In this pilot study the effects of vitrectomy on PO(2) in the vitreous cavity in CRVO were investigated...
  101. ncbi Small interfering RNA targeting of Recepteur d'Origine Nantais induces apoptosis via modulation of nuclear factor-kappaB and Bcl-2 family in gastric cancer cells
    Jung Sun Park
    The Brain Korea 21 Project, Center for Biomedical Human Resources and Research Institute of Medical Sciences at Chonnam National University Medical School, Gwangju 501 190, Korea
    Oncol Rep 24:709-14. 2010
    The abnormal accumulation and activation of the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON), has been implicated in tumorigenesis and metastasis in epithelial tumors including gastric cancer...

Research Grants65

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..This chimeric HGF-MSP protein can bind to HGF receptor c-Met and MSP receptor Ron independently and elicit a biological signal only through Met-Ron heterodimerization...
  2. Susan E Waltz; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Ron receptor tyrosine kinase has recently been shown to be overexpressed and activated in a cohort of human cancers, with the most compelling data found in breast cancer...
  3. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
    ..We have recently found that the majority of primary and metastatic pancreatic adenocarcinomas over-express the RON receptor tyrosine kinase (RTK)...
  4. Joseph W Harding; Fiscal Year: 2014
    ..Recent studies have implicated the over activation of two growth factor systems macrophage stimulating protein(MSP)/RON (its receptor) and hepatocyte growth factor(HGF)/c- Met(its receptor) as critical contributors to pancreatic cancer&..
  5. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ..We have found that oxidant-induced epithelial AJC junction disruption is mediated by RON, a tyrosine kinase receptor that is uniquely localized at the apical membrane of airway epithelia...
  6. Jing Wang; Fiscal Year: 2014
    ..b>Ron kinase (recepteur d'origine nantais) is a member of the Met proto-oncogene family...
  7. Ken A Paller; Fiscal Year: 2015
    ..Associate Director), with the assistance of an internal Steering Committee and an External Advisory Committee (Ron Mangun, Marcia Johnson, John Jonides, and Larry Squire)...
  8. LIVER REGENERATION AND GROWTH FACTORS
    SANDRA DEGEN; Fiscal Year: 2000
    ..stimulating protein (MSP), and a cell surface tyrosine kinase receptor for HGF-like protein, referred to as Ron, has been identified...
  9. Drosophila tracheal cytonemes in long range FGF signaling
    Sougata Roy; Fiscal Year: 2013
    ..b>Ron Vale, Professor in the UCSF Department of Cellular and Molecular Pharmacology, world renowned for his contributions ..
  10. JOE ROBERT NOCERA; Fiscal Year: 2015
    ..Joe R. Nocera as the Principal Investigator and a mentoring team of Drs. Bruce Crosson, Ron Shorr, Marco Pahor and Michael Marsiske. Dr. Nocera received his undergraduate degree (B.A...
  11. Sabine Petry; Fiscal Year: 2015
    ..b>Ron Vale)...
  12. Role and Mechanism of Microtubule Nucleation within the Mitotic Spindle
    Sabine Petry; Fiscal Year: 2013
    ..b>Ron Vale)...
  13. ANDREW PALUCH; Fiscal Year: 2015
    ..One such receptor, the Ron receptor tyrosine kinase, has been shown by our laboratory to be overexpressed in human prostate cancer and that ..
  14. Estimation of Intervention Effects in Influenza Outbreaks
    Justin Lessler; Fiscal Year: 2012
    ..In addition, the candidate will continue to consult with his mentors Dr. Ron Brookmeyer (on statistical matters), and Dr. Charlotte Gaydos (on laboratory topics and virology)...
  15. Defining the role of ubiquitination in the regulation of lipid droplet function
    James A Olzmann; Fiscal Year: 2013
    ..During the mentored K99 phase of this award I will work closely with my mentors Dr. Ron Kopito and Dr. Robert Farese Jr...
  16. James A Olzmann; Fiscal Year: 2015
    ..During the mentored K99 phase of this award I will work closely with my mentors Dr. Ron Kopito and Dr. Robert Farese Jr...
  17. Neil J Ganem; Fiscal Year: 2015
    ..I have assembled a stellar mentoring and advisory committee (Dr. David Pellman, Dr. William Kaelin, Dr. Ron Depinho, Dr. Matt Meyerson, and Dr. William Hahn) that will greatly benefit my research and training experience...
  18. Defining novel pathways that arrest genetically unstable tetraploid cells
    Neil J Ganem; Fiscal Year: 2012
    ..I have assembled a stellar mentoring and advisory committee (Dr. David Pellman, Dr. William Kaelin, Dr. Ron Depinho, Dr. Matt Meyerson, and Dr. William Hahn) that will greatly benefit my research and training experience...
  19. HERPESVIRUSES AS VACCINE VECTORS FOR AIDS
    David M Knipe; Fiscal Year: 2010
    ..Amitinder Kaur and Ron Desrosiers Immune Responses and Protection in Macaques Immunized with HSV Vaccine Vectors...
  20. The biology of Ron, the HGF-like protein receptor
    SANDRA DEGEN; Fiscal Year: 2004
    ..The cell surface receptor for HGFL has been found to be the Ron tyrosine kinase receptor; a member of the c-Met proto-oncogene family, c-Met is the receptor for HGF...
  21. The RON Receptor in the Invasive Growth of Colon Cancer
    Ming hai Wang; Fiscal Year: 2012
    ..During the study of CRC progression towards malignancy, we found that splicing variants of the RON receptor tyrosine kinase, such as oncogenic RON160, play a critical role in priming CRC cells with metastatic ..
  22. Hepatocyte Growth Factor-like Protein Receptor
    Susan Waltz; Fiscal Year: 2009
    ..applicant): The long-term objective of my research is to define the in vivo role of the receptor tyrosine kinase Ron in liver pathophysiology. Virtually nothing is known regarding the function of Ron in the liver...
  23. Development of a Syndemic Model Among Gay/Bisexual Male Adolescents/Young Adults
    Douglas Bruce; Fiscal Year: 2013
    ..Dr. Ron Stall will act as a co- mentor and supervise my training in developing and testing a model of syndemic production ..
  24. Structure-Function studies of human hyaluronidases
    Osnat Herzberg; Fiscal Year: 2012
    ..function and inhibition, and their interactions with protein partners, CD44 - the hyaluronan biding protein, RON receptor tyrosine kinase that is regulated by hHyal-2, and Jaagsiekte sheep retrovirus envelope protein that ..
  25. The Ron Receptor/Chemokine Axis in Prostate Cancer
    Susan E Waltz; Fiscal Year: 2012
    ..Moreover, we also demonstrate that the Ron receptor tyrosine kinase is highly expressed in human prostate tumors and prostate cancer cell lines...
  26. Mucociliary Function in Chronic Bronchitis
    MATTHIAS A SALATHE; Fiscal Year: 2010
    ..acidification due to H+ production by Duox;in addition, direct apical hyaluronan degradation activates RHAMM and RON to stimulate CBF and possibly increase ASL volume...
  27. HEPATOCYTE GROWTH FACTOR LIKE PROTEIN RECEPTOR
    Susan Waltz; Fiscal Year: 2003
    The long term goal of this proposal is to determine the in vivo function of the tyrosine kinase receptor known as Ron. Based on in vitro analyses, Ron has been postulated to have a critical role in cellular proliferation, dissociation ..
  28. Yukari Takarae; Fiscal Year: 2014
    ..A group of outstanding mentors and consultants will serve to provide scientific and career advice. Dr. Ron Mangun will serve as the primary mentor. Dr...
  29. James W Freeman; Fiscal Year: 2014
    ..Our preliminary data details the discovery of a dynamic cross talk between Ron kinase and Smad-independent TGF2 signaling that promotes tumor growth, invasion and metastasis...
  30. Using Computed Tomographic Imaging as a biomarker for Clinical COPD Research
    George R Washko; Fiscal Year: 2012
    ..b>Ron Kikinis, MD, an expert in quantitative image analysis and interpretation. (End of Abstract)
  31. Developing a Community Level Behavioral Intervention for MSM in Thailand
    Thomas E Guadamuz; Fiscal Year: 2013
    ..b>Ron Stall...
  32. Ron/EGFR interactions and therapeutic resistance in head and neck cancers
    MICHAEL JOHN HAYMAN; Fiscal Year: 2010
    ..Recent data suggested that there is potential cross talk between EGFR and Ron. We also discovered that overexpressing Ron not only transactivates EGFR, but also modulates its signaling such ..
  33. The Ron Receptor Tyrosine Kinase in Hepatic Tumorigenesis
    Mike A Leonis; Fiscal Year: 2010
    ..a mechanistic-based approach that will allow the principal investigator to establish that gain-of-function of the Ron receptor tyrosine kinase is sufficient for hepatic tumor formation...
  34. TAS::75 0849::TAS SBIR TOPIC 292 PHASE I DEVELOPMENT OF MOLECULAR PHARMACODYNAMI
    DAVID CHIMENTO; Fiscal Year: 2011
    The RON and c-MET signal pathways are critical regulators of cell growth, survival, migration, differentiation, and drug resistance. High levels of activated RON or c-MET have been observed in a number of human cancers...
  35. Andrew M Lowy; Fiscal Year: 2015
    ..Our group and others identified the RON tyrosine kinase receptor as an overexpressed protein and potential novel therapeutic target in pancreatic cancer...
  36. Alana L Welm; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Met and Ron are two related receptor-tyrosine kinases that have been implicated in tumor growth and metastasis...
  37. Audrey French; Fiscal Year: 2014
    ..There will be: an Administrative Core (Drs. Alan Landay and Linda Baum);a Developmental Core (Drs. Greg Spear and Ron Hershow);a Basic Science Core (Drs. Michael Caffrey and James Bremer);a Clinical Core (Drs...
  38. Randy D Blakely; Fiscal Year: 2016
    ..In Project 4, Ron Emeson brings his group's advanced understanding in 5HT2c receptor expression and signaling to bear on the ..
  39. Flow Visualization in the Canine Larynx During Phonation
    Siddarth Khosla; Fiscal Year: 2006
    ..The coursework will be supplemented by tutorials in speech science given by the candidate?s mentor, Dr. Ron Scherer...
  40. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..b>Ron Kahn's group, as I move to independence, provides me with a unique perspective to explore the interactions between ..
  41. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..In IL10-/- mice, piroxicam (a NSAID) induces chronic Th1 colitis and expression of NK-1 Ron gut T cells like seen in human IBD...
  42. Lisa M McLeod; Fiscal Year: 2014
    ..To accomplish her transition, Dr. McLeod has assembled an outstanding team of mentors led by Ron Keren, MD, MPH and renowned orthopedic surgeon, John Dormans, MD, and will continue to benefit from the rich ..
  43. HEALTH STATUS AND FAMILY SUPPORT OF THE ELDERLY
    ROBERT SCHOENI; Fiscal Year: 2001
    ..b>Ron D. Hays is a Senior Social Policy Analyst at RAND and Adjunct Associate Professor at the UCLA School of Medicine...
  44. OREGON CHILD HEALTH RESEARCH CENTER
    HENRY STACY NICHOLSON; Fiscal Year: 2012
    ..I.), De-Ann M. Pillers, M.D., Ph.D. (Program Director and co-P.I.), David Koeller,M.D. (Asst. Prog. Dir.), Ron G. Rosenfeld, M.D. (External Advisor;Stanford University), and Ella Booth,Ph.D...
  45. CHILD HEALTH RESEARCH CENTER
    Ron Rosenfeld; Fiscal Year: 2000
    ..at the Oregon Health Sciences University and Doernbecher Children's Hospital, Portland, under the direction of Ron G. Rosenfeld, M.D., Chair of the Department of Pediatrics, OHSU...
  46. Prediciting Severe Neonatal Hyperbilirubinemia
    Ron Keren; Fiscal Year: 2007
    ..b>Ron Keren as an independent patient-oriented clinical researcher. To achieve this goal, Dr...
  47. BIOCHEMICAL RESEARCH ON OPIOID RECEPTORS
    Eric Simon; Fiscal Year: 2003
    ..b>Ron Beavis, a leading expert in this technology...
  48. GENOME ANALYSIS OF CRYPTOCOCCUS NEOFORMANS
    Claire Fraser Liggett; Fiscal Year: 2002
    ..In this application we propose to build upon ongoing efforts of Drs. Ron Davis and Richard Hyman at Stanford University to provide 4-5X sequence coverage of the C...
  49. Sensory and Motor Fusion in Abnormal Binocular Vision
    PATRICIA FREDENBURG; Fiscal Year: 2005
    ..perception, and statistics, as well as hands-on participation in experiments in binocular vision in the lab of Ron Harwerth, O.D., Ph.D, at the University of Houston College of Optometry...
  50. Interdisciplinary Training in Quantitative Cell Biology
    RONALD VALE; Fiscal Year: 2006
    ..The co-directors for the course, Ron Vale and Tim Mitchison are leading cell biologists with strong training records...
  51. HIV 1 CORECEPTORS AND THEIR ROLE IN HEMATOPOIESIS
    Benhur Lee; Fiscal Year: 2002
    ..b>Ron Collman and Jim Hoxie, both well-respected authorities in the HIV/chemokine receptor fields...
  52. MODELING THE UNDERSTANDING OF CHILDHOOD ASTHMA
    Adrian Casillas; Fiscal Year: 2002
    ..The sponsor, Dr. Ron Stevens, is Professor of Microbiology and Immunology and of Education...
  53. Regulation of Her2/neu by activation loop phosphorylation and ALG-2
    Ron Bose; Fiscal Year: 2009
    The candidate, Ron Bose, M.D., Ph.D., is a graduate of the Medical Scientist Training Program held jointly at Cornell University- Rockefeller University- Memorial Sloan-Kettering Cancer Center. His Ph.D...
  54. Enzymes, Coenzymes, and Metabolic Pathways
    Karen Anderson; Fiscal Year: 2001
    ..of North Carolina), Tom Leyh (Albert Einstein College of Medicine), Ron Breaker (Yale ), Steve Ealick (Cornell University), Natalie Ahn (University of Colorado, Boulder), Kevin Shokat (..
  55. MULTISPECTRAL FP-TIR MICROSCOPY FOR NEUROBIOLOGY
    Richard Levenson; Fiscal Year: 2001
    ..Feasibility: In collaboration with neurobiologist Ron Holz (Michigan): (a) visualize membrane-folding and fusion events related to secretion in chromaffin cells at near-..
  56. ROCHESTER CARIES RESEARCH CENTER
    William Bowen; Fiscal Year: 1993
    ..Irwin Mandel. Dr. Jason Tanzer, Dr. Mark Herzberg. and Dr Ron Yasbin) has been appointed to advise in monitoring research progress an evaluating new proposals...
  57. FASEB Growth Factor Receptor Tyrosine Kinases Confence
    ALPHONSE SIRICA; Fiscal Year: 2001
    ..in malignant disease, growth factor therapy in non-malignant diseases, and on the biology and pathobiology of the Ron/Stk receptor tyrosine kinase...
  58. Novel System to Study Telomere Dynamics in Hemotopoiesis
    Ruben Carrasco; Fiscal Year: 2005
    ..He also holds a Ph.D. in Biochemistry. The research will be carried out in a cancer/aging biology laboratory within the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School, under the mentorship of Dr. Ron DePinho.
  59. PREVENTING HARMFUL AND HAZARDOUS DRINKING IN THE ELDERLY
    Alison Moore; Fiscal Year: 2003
    ..Dr. Moore's sponsors are Drs. David Reuben, Ron Hays, and Thomas Babor...
  60. LIPIDS AS MODULATORS OF GENE EXPRESSION
    Roger Davis; Fiscal Year: 1999
    ..Session III will be moderated by Helen Hobbs; speakers will be Ron Evans, Chris Glass, Mike Milburn, and Helen Hobbs...
  61. Kern Aspen Lipid Conference
    Alan Tall; Fiscal Year: 2007
    ..The Board of Directors has chosen Alan Tall and Ron Evans to be the co-chairs of the meeting, and they have worked together in developing the proposed program...
  62. STRUCTURE/FUNCTION STUDIES ON HUMAN TELOMERASE
    WILLIAM DROSOPOULOS; Fiscal Year: 2004
    ..Part of the training experience will involve collaboration with Dr. Ron Depinho, an acknowledged expert in the field of cancer research...
  63. Comprehensive Minority Biomedical Behavior
    Ronald Peters; Fiscal Year: 2009
    ..b>Ron Peters for a career of independent research in cancer prevention and smoking cessation for African-American youth...
  64. A NEURAL NETWORK MODEL OF EPILEPTIFORM ACTIVITY
    PIOTR FRANASZCZUK; Fiscal Year: 2005
    ..Using reduced compartment neurons based on modified Av-Ron Rinzel equations, networks can be assembled that can simulate recurrent bursting behavior and seizure propagation...