RNPC3

Summary

Gene Symbol: RNPC3
Description: RNA binding region (RNP1, RRM) containing 3
Alias: RBM40, RNP, SNRNP65, RNA-binding protein 40, RNA recognition protein, RNA-binding motif protein 40, RNA-binding region-containing protein 3, U11/U12 small nuclear ribonucleoprotein 65 kDa protein, U11/U12 snRNP 65 kDa protein, U11/U12 snRNP 65K, U11/U12-65K
Species: human

Top Publications

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
  3. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
  4. pmc The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein
    Heike Benecke
    Department of Cellular Biochemistry, MPI of Biophysical Chemistry, Gottingen, Germany
    EMBO J 24:3057-69. 2005
  5. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
  6. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
  7. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
  8. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
  9. doi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
  10. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997

Detail Information

Publications215 found, 100 shown here

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
    ..a fine speckled fluorescence, found in 45% of sera, consistent with reactivity against the Sm antigen or nuclear RNP. The finding of a high prevalence of ANA and, less often, anti-connective tissue antibodies in patients with ..
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
    ..examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution...
  3. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..Only sera from DR3 and DQ0604 mice immunoprecipitated A-ribonucleoprotein (RNP), SmB, and SmD...
  4. pmc The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein
    Heike Benecke
    Department of Cellular Biochemistry, MPI of Biophysical Chemistry, Gottingen, Germany
    EMBO J 24:3057-69. 2005
    ..Taken together, these data suggest that U11/U12-65K and U11-59K contribute to di-snRNP formation and intron bridging in the minor prespliceosome...
  5. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
    ..We speculate that the perturbations in mRNA processing are the result of effects on the chromatin-nascent RNP-transcription complex or misregulation of a cell cycle component that modifies multiple mRNA-processing activities.
  6. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
    ..Some nucleoli were surrounded by a double fibrillar layer limiting a perinucleolar space occupied by RNP fibrogranular structures that differed from those of normal nuclei...
  7. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
    ..To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease...
  8. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
    ..Their cytoplasm occasionally displays RNP granules, and is rich in non-histone proteins, fine phospholipid, lipid or cholesterin granules, and vacuoles ..
  9. doi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
    ..These auto-antibodies are directed against nuclear or nucleolar auto-antigens: the anti-PM-Scl, anti-Ku, anti-RNP (U1 RNP and U2 RNP, U4/U6 RNP and U5 RNP), anti-Ro 52 kDa and more rarely, anti-Ro 60 kDa and anti-La...
  10. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997
    ..Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases...
  11. pmc Investigating the specificity and stoichiometry of RNA binding by the nucleocapsid protein of Bunyamwera virus
    Bjorn Patrick Mohl
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS29JT, West Yorkshire, United Kingdom
    RNA 15:391-9. 2009
    ..along their entire lengths with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex...
  12. pmc Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein
    M J Matunis
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104 6148
    Mol Cell Biol 12:164-71. 1992
    At least 20 major proteins make up the ribonucleoprotein (RNP) complexes of heterogeneous nuclear RNA (hnRNA) in mammalian cells. Many of these proteins have distinct RNA-binding specificities...
  13. ncbi Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme
    Shin Kawano
    Laboratory of Biochemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    J Mol Biol 357:583-91. 2006
    ..beta-sheet and five helices, which fold in a way that is topologically similar to the ribonucleoprotein (RNP) domain...
  14. ncbi [Low prevalence of anti-centromere antibodies in scleroderma in Morocco (about 272 cases)]
    B Admou
    Faculte de Medecine, Marrakech, Morocco
    Ann Biol Clin (Paris) 65:291-7. 2007
    ..assessment of autoantibodies prevalence during scleroderma within a Moroccan population by a retrospective survey...
  15. ncbi Neonatal lupus erythematosus: an unusual congenital presentation with cutaneous atrophy, erosions, alopecia, and pancytopenia
    E Crowley
    University of Illinois, College of Medicine, Urbana, USA
    Pediatr Dermatol 15:38-42. 1998
    ..Ro, La, and RNP antibodies were absent, and the diagnosis was made because of light microscopic and immunofluorescent findings...
  16. doi Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China
    Xuhua Tang
    Department of Dermatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Medicine (Baltimore) 89:62-7. 2010
    ..with higher prevalence of malar rash/discoid rash, pericarditis, and leukopenia; anti-ribonucleoprotein (anti-RNP) with higher prevalence of Raynaud phenomenon and photosensitivity; anti-deoxyribonucleoprotein (anti-DNP) with ..
  17. ncbi Age-correlated changes in the lupus erythematosus antigens Ro, La, Sm and RNP of the thymus gland
    W E Muller
    Institut fur Physiologische Chemie, Universitat, Mainz, West Germany
    Compr Gerontol A 1:40-4. 1987
    The concentrations of the Sm, RNP, La and Ro antigens of thymus glands from rats were determined depending on the developmental stage of the animals. It was found that lupus antigens strongly decrease after birth...
  18. pmc Development of recombinant nucleoprotein-based diagnostic systems for Lassa fever
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Clin Vaccine Immunol 14:1182-9. 2007
    ..for the detection of LASV antibodies and LASV antigens, were developed using the recombinant nucleoprotein (rNP) of LASV (LASV-rNP). The LASV-rNP was expressed in a recombinant baculovirus system...
  19. ncbi Atypical autoantibodies in patients with primary Sjögren syndrome: clinical characteristics and follow-up of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 35:312-21. 2006
    ..To analyze the clinical characteristics, follow-up, and fulfillment of classification criteria for other systemic autoimmune diseases (SAD) in patients with primary Sjögren syndrome (SS) and atypical autoantibodies...
  20. ncbi The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis
    R Hesselstrand
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Rheumatology (Oxford) 42:534-40. 2003
    ..To study the frequency and specificity of antinuclear antibodies (ANA) and their association with internal organ involvement and survival in systemic sclerosis (SSc)...
  21. ncbi Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon
    Katsuhisa Omagari
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Autoimmunity 36:269-73. 2003
    ..hepatitis C and 44 patients with non-hepatitis C virus (HCV) infected liver diseases were tested for anti-ENAs (U1 RNP, Sm, Ro/SS-A, La/SS-B and Scl-70) antibodies by enzyme-linked immunosorbent assay (ELISA)...
  22. ncbi [Resistance to the action of atrial natriuretic peptide and urodilatin in Heymann nephritis in vitro]
    J P Valentin
    Department of Medicine, San Francisco General Hospital, CA, USA
    Arch Mal Coeur Vaiss 87:1125-9. 1994
    ..glomeruli and inner medullary collecting duct (IMCD) cells in response to increasing concentration of ANP, and RNP (also called urodilatin). Results (fmol/mg prot/10 min) are means +/- SEM: [table: see text]...
  23. doi Infectious Bursal disease virus: ribonucleoprotein complexes of a double-stranded RNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, C Darwin No 3, Cantoblanco, E 28049 Madrid, Spain
    J Mol Biol 386:891-901. 2009
    ..dsRNA viruses nevertheless lack these ribonucleoprotein (RNP) complexes and are characterized by sharing an icosahedral T=2 core involved in the metabolism and insulation of ..
  24. ncbi High level expression of recombinant mumps nucleoprotein in Saccharomyces cerevisiae and its evaluation in mumps IgM serology
    Dhanraj Samuel
    Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Med Virol 66:123-30. 2002
    ..for mumps serology a high-level yeast expression system was employed to produce recombinant mumps nucleoprotein (rNP). The rNP was purified by CsCl gradient centrifugation and yielded approximately 15 mg/l of yeast culture...
  25. ncbi A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
    ..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
  26. ncbi Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?
    C H To
    division of Rhumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 52:4003-10. 2005
    ..To examine autoantibody clusters and their associations with clinical features and organ damage accrual in patients with systemic lupus erythematosus (SLE)...
  27. pmc Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex
    M Kiledjian
    Department of Cell, Developmental and Neurobiology, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Cell Biol 17:4870-6. 1997
    ..is an important regulatory component of gene expression and is significantly influenced by ribonucleoprotein (RNP) complexes which form on the mRNA...
  28. pmc Childhood-onset systemic lupus erythematosus: a comparative study of African Americans and Latin Americans
    A Gedalia
    Department of Pediatrics, LSU Medical Center, New Orleans 70112 2822, USA
    J Natl Med Assoc 91:497-501. 1999
    ..In addition, there was a higher frequency of anti-dsDNA, anti-Sm, anti-RNP, and anti-Ro positivity among African-Americans compared with Latin-American patients...
  29. ncbi Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase
    R Rajpurohit
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
    J Biol Chem 269:1075-82. 1994
    ....
  30. doi Specific humoral reaction of hemorrhagic fever with renal syndrome (HFRS) patients in China to recombinant nucleocapsid proteins from European hantaviruses
    H R Xiong
    State Key Laboratory of Virology Institute of Medical Virology, School of Medicine, Wuhan University, 185 DongHu Road, Wuhan 430071, PR China
    Eur J Clin Microbiol Infect Dis 30:645-51. 2011
    ..The results showed that the sensitivity of rNPs against IgG was HTNV-rNP > DOBV-rNP > PUUV-rNP, while the sensitivity against IgA was DOBV-rNP > HTNV-rNP > PUUV-rNP...
  31. ncbi Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes
    G Schlenstedt
    Zentrum Biochemie/Abt. Biochemie II, , Germany
    J Biol Chem 267:24328-32. 1992
    ..We investigated the role of the precursor structure with respect to competence for RNP-independent transport by constructing deletion mutants and hybrid proteins...
  32. ncbi C-reactive protein reacts with the U1 small nuclear ribonucleoprotein
    T W Du Clos
    Department of Medicine, VA Medical Center, Albuquerque, New Mexico 87108
    J Immunol 143:2553-9. 1989
    ..Double staining with anti-RNP serum and CRP produced very similar staining patterns...
  33. doi Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features
    Shyamasri Biswas
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States
    Biochemistry 50:2907-18. 2011
    Box C/D ribonucleoproteins (RNP) guide the 2'-O-methylation of targeted nucleotides in archaeal and eukaryotic rRNAs. The archaeal L7Ae and eukaryotic 15...
  34. doi pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances
    Toru Yoshitomi
    Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, 305 8573, Ibaraki, Japan
    Bioconjug Chem 20:1792-8. 2009
    For the imaging of low pH circumstances in vivo, a pH-sensitive radical-containing-nanoparticle (RNP), which has an intense electron paramagnetic resonance (EPR) signal, was designed and developed using a self-assembling amphiphilic ..
  35. ncbi Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 168:5326-32. 2002
    ..Ab responses, we immunized A/J mice with recombinant Smith D (SmD), Smith B (SmB), and A ribonucleoprotein (A-RNP) with alum as adjuvant...
  36. ncbi Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using electron paramagnetic resonance spectroscopy
    V Gopalan
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 38:1705-14. 1999
    Ribonuclease P (RNase P) is a catalytic ribonucleoprotein (RNP) essential for tRNA biosynthesis. In Escherichia coli, this RNP complex is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C5 protein...
  37. pmc Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo
    B Dichtl
    EMBL, Gene Expression Programme, Heidelberg, Germany
    EMBO J 16:417-29. 1997
    RNase MRP is a ribonucleoprotein (RNP) particle which is involved in the processing of pre-rRNA at site A3 in internal transcribed spacer 1...
  38. pmc An umbraviral protein, involved in long-distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes
    Michael Taliansky
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
    J Virol 77:3031-40. 2003
    ..of the TMV CP [TMV(ORF3)], in infected cells it interacted with the TMV RNA to form filamentous ribonucleoprotein (RNP) particles that had elements of helical structure but were not as uniform as classical virions...
  39. pmc Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata
    Steffan W Schulz
    Division of Rheumatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Semin Arthritis Rheum 39:410-6. 2010
    ....
  40. ncbi Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: a study combining anterograde tracing with immunogold labeling in the rat
    C Schwarz
    Sektion fur Visuelle Sensomotorik, Neurologische Universitätsklinik Tübingen, Germany
    J Comp Neurol 381:320-34. 1997
    ..that of cerebellonuclear terminals in two other target structures, the parvocellular part of the nucleus ruber (RNp) and the ventromedial and ventrolateral thalamus (VM/VL)...
  41. pmc A polypyrimidine tract binding protein, pumpkin RBP50, forms the basis of a phloem-mobile ribonucleoprotein complex
    Byung Kook Ham
    Department of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Cell 21:197-215. 2009
    RNA binding proteins (RBPs) are integral components of ribonucleoprotein (RNP) complexes and play a central role in RNA processing. In plants, some RBPs function in a non-cell-autonomous manner...
  42. pmc The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex
    Gopal P Patel
    Department of Molecular and Cellular Biology, University of Guelph Guelph, Ontario, Canada, N1G 2W1
    Nucleic Acids Res 33:7074-89. 2005
    ..Using a modified ribonucleoprotein (RNP) immunoprecipitation procedure we further show that indeed, both IMP1 and UNR bind to the ARS containing reporter ..
  43. ncbi [Study on the recombinant expression of Hantaan virus protein N and the establishment and application of rNP-IgM direct capture ELISA]
    Han ping Zhu
    Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:692-6. 2007
    ..NP) of hantavirus strain Z10 (HV-Z10), to construct its prokaryotic expression system as well as to establish a rNP-IgM direct capture ELISA based on HRP-labeled recombinant NP (rNP), in order to detect serum samples of patients ..
  44. pmc Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons
    Honglai Zhang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:8622-32. 2006
    ..In immortalized non-neuronal cell lines, SMN has been shown to form a ribonucleoprotein (RNP) complex with Gemin proteins, which is essential for the assembly of small nuclear RNPs (snRNPs)...
  45. ncbi RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts
    Jack D Keene
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Protoc 1:302-7. 2006
    ..which mRNAs associate, nor can they be used to elucidate the dynamic composition of RNAs in ribonucleoprotein (RNP) complexes in response to physiological stimuli...
  46. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..VSV is required to induce activation of the IKK-related kinases and provide evidence that ribonucleoprotein (RNP) complex of VSV generated intracellularly during virus replication can activate TBK1 and IKKepsilon activity...
  47. ncbi Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    J Rheumatol 28:2454-9. 2001
    ..To evaluate the independent contribution of several clinical and laboratory variables to the mortality of a cohort of Danish patients with systemic sclerosis (SSc)...
  48. doi Development of the human parvocellular red nucleus. A morphological study
    Katsuyuki Yamaguchi
    Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Dev Neurosci 30:325-30. 2008
    Morphology of the human parvocellular red nucleus (RNp) was investigated in 14 fetuses aged from 12 to 39 weeks of gestation (WG). The brains were processed into celloidin-embedded serial sections...
  49. pmc Evidence for different contributions of archaea and bacteria to the ammonia-oxidizing potential of diverse Oregon soils
    Anne E Taylor
    Department of Crop and Soil Science, 3017 ALS, Oregon State University, Corvallis, OR 97331, USA
    Appl Environ Microbiol 76:7691-8. 2010
    ..inactivate ammonia monooxygenase, and upon the removal of acetylene, the recovery of nitrification potential (RNP) was monitored in the presence and absence of bacterial or eukaryotic protein synthesis inhibitors...
  50. ncbi Incorporation of argyrophilic proteins into the nucleolus-associated chromatin caused by exposure to actinomycin D
    S Sato
    Department of Biology, Faculty of Science, Ehime University, Japan
    Biol Cell 63:19-26. 1988
    ..is formed, detailed observations were carried out on thin sections following silver staining and ribonucleoprotein (RNP) preferential staining...
  51. ncbi Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction
    K B Elkon
    Hospital for Special Surgery, Cornell Medical Center, New York, NY 10021
    J Immunol 145:636-43. 1990
    SmB and SmB' are the major antigenic proteins contained within small nuclear RNP particles that are recognized by both human SLE and MRL mouse anti-Sm sera...
  52. ncbi Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods
    Sophie Desplat-Jego
    Laboratoire d Immunologie, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1109:245-55. 2007
    ..detection of antibodies against the following antigens: dsDNA, chromatin, SSA-52 kDa, SSA-60 kDa, SSB, Sm, Sm/RNP, RNP-A, RNP-68 kDa, Scl70, centromere B, Jo-1, and P ribosomal proteins...
  53. ncbi In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen
    Kindra M Kelly-Scumpia
    University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 56:3379-86. 2007
    ..This study was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo...
  54. doi Determination of protein-RNA interaction sites in the Cbf5-H/ACA guide RNA complex by mass spectrometric protein footprinting
    Daniel L Baker
    Department of Biochemistry and Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 47:1500-10. 2008
    ..In eukaryotes and archaea, these modifications are carried out by H/ACA ribonucleoprotein (RNP) complexes, composed of an H/ACA guide RNA and four proteins, including the pseudouridine synthase, Cbf5...
  55. pmc HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS)
    M Rischmueller
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre and Flinders University of South Australia
    Clin Exp Immunol 111:365-71. 1998
    ..explained by intermolecular spreading of autoimmunity toward different components of the La/Ro ribonucleoprotein (RNP)...
  56. doi Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation
    Alvaro D Ortega
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa CBMSO, CSIC UAM, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, ISCIII, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Cell Sci 123:2685-96. 2010
    ..the mitochondrial H(+)-ATP synthase subunit beta (ATP5B, beta-F1-ATPase) is localized in a large ribonucleoprotein (RNP) complex (beta-F1-RNP), which is subjected to stringent translational control during development and the cell cycle,..
  57. ncbi Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide
    K Yamamoto
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 140:311-7. 1988
    ..vector lambda gt11 after screening with a patient's serum containing a high titer of anti-ribonucleoprotein (RNP) antibodies...
  58. ncbi [Extrachromosomal structures containing small nuclear RNP and coilin in the late vitellogenic oocytes of hibernating grass frogs]
    A G Tsvetkov
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 44:1037-45. 2002
    ..were also positively stained with antibodies against Sm-epitope and trimetylguanosine cap of small nuclear (sn) RNP. According to the results of in situ nucleic acid hybridization, the nucleoli contain U6 snRNA...
  59. doi Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein
    J Hepojoki
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Gen Virol 91:2341-50. 2010
    Here we characterize the interaction between the glycoproteins (Gn and Gc) and the ribonucleoprotein (RNP) of Puumala virus (PUUV; genus Hantavirus, family Bunyaviridae)...
  60. pmc Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes
    Alexis J Rodriguez
    Department of Biological Sciences, Rutgers University, 101 Warren Street, 135 Smith Hall, Newark, NJ 07102, USA
    RNA 11:646-56. 2005
    ..Seawi is a major component of microtubule-ribonucleoprotein (MT-RNP) complexes isolated from two different species of sea urchin, Strongylocentrotus purpuratus and Paracentrotus ..
  61. ncbi Autoantibodies in systemic sclerosis
    Virginia D Steen
    Department of Medicine, Georgetown University, Washington, DC 2007, USA
    Semin Arthritis Rheum 35:35-42. 2005
    ..To describe the clinical, laboratory, and prognostic features associated with the scleroderma-specific autoantibodies...
  62. ncbi Multiple plant RNA binding proteins identified by PCR: expression of cDNAs encoding RNA binding proteins targeted to chloroplasts in Nicotiana plumbaginifolia
    M Mieszczak
    Friedrich Miescher Institut, Basel, Switzerland
    Mol Gen Genet 234:390-400. 1992
    ..90 amino acids with a characteristic ribonucleoprotein consensus sequence (RNP-CS). A PCR approach that is suitable for the characterization of RNP-CS-type proteins is described...
  63. ncbi The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems
    G N Andrianov
    Laboratory of Physiology of Reception, Pavlov Institute of Physiology, Russian Academy of Sciences, nab Makarova 6, St Petersburg 199034, Russia
    Hear Res 230:1-8. 2007
    ..study investigated the electrophysiological effects of externally applied human and rabbit defensins (HNP-1 and RNP-1, correspondingly) on afferent neurotransmission in the frog semicircular canals (SCC)...
  64. pmc GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program
    Kyung Won Kim
    Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 107:17445-50. 2010
    ..One GLD-2 partner, RNP-8, was previously shown to influence oocyte fate specification...
  65. pmc Endothelial cell-binding activity of anti-U1-ribonucleoprotein antibodies in patients with connective tissue diseases
    M Okawa-Takatsuji
    Division of Clinical Immunology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Clin Exp Immunol 126:345-54. 2001
    In order to elucidate the immunological properties of anti-U1-ribonucleoprotein (RNP) antibody, one of the autoantibodies detected in patients with connective tissue diseases (CTDs), we tested the endothelial cell-binding by anti-U1-RNP ..
  66. ncbi Effects of forest structure and composition on food availability for Varecia variegata at Ranomafana National Park, Madagascar
    Elizabeth A Balko
    Faculty of Environmental and Forest Biology, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13215, USA
    Am J Primatol 66:45-70. 2005
    ..were measured in three adjacent study areas, with different histories of disturbance, in Ranomafana National Park (RNP), Madagascar. V...
  67. pmc Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs
    Xiaoze Li
    Department of Laboratory Medicine, Section of Medical Microbiology, Lund University, 221 84 Lund, Sweden
    Nucleic Acids Res 41:10488-508. 2013
    ..The AUAGUA motifs bind specifically not only to the heterogeneous nuclear RNP (hnRNP) D family of RNA-binding proteins including hnRNP D/AUF, hnRNP DL and hnRNP AB but also to hnRNP A2/B1...
  68. doi Structural perspective on the formation of ribonucleoprotein complex in negative-sense single-stranded RNA viruses
    Honggang Zhou
    State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China Laboratory of Structural Biology and Ministry of Education MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
    Trends Microbiol 21:475-84. 2013
    Negative-sense single-stranded RNA viruses (NSRVs) possess a ribonucleoprotein (RNP) complex composed of viral polymerase and genomic RNA surrounded by viral nucleoprotein...
  69. doi Designed Regular Tetragon-Shaped RNA-Protein Complexes with Ribosomal Protein L1 for Bionanotechnology and Synthetic Biology
    Hirohisa Ohno
    Laboratory of Gene Biodynamics, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    ACS Nano 9:4950-6. 2015
    ..In summary, the RNP object will serve as a useful tool in the fields of bionanotechnology and synthetic biology...
  70. pmc RNA protein granules modulate tau isoform expression and induce neuronal sprouting
    Katharina Moschner
    From the Departments of Neurobiology and
    J Biol Chem 289:16814-25. 2014
    ..that G3BP1 and IMP1 expression induces the formation of structures, which qualify as neuronal ribonucleoprotein (RNP) granules and concentrate multivalent proteins and mRNA...
  71. doi Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation
    Kazuho Nishimura
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8577, Japan
    Cell Rep 10:1310-23. 2015
    The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress...
  72. ncbi Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition
    Deanna A Kulpa
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    Hum Mol Genet 14:3237-48. 2005
    ..ORF1p and ORF2p) preferentially associate with their encoding transcript to form a ribonucleoprotein particle (RNP), which is a proposed retrotransposition intermediate...
  73. doi The pre-mRNA splicing reaction
    Somsakul Pop Wongpalee
    Department of Immunology and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles, CA, USA
    Methods Mol Biol 1126:3-12. 2014
    ..Pre-mRNA splicing removes introns and joins exons to form mature mRNAs. It is catalyzed by a large RNP complex called the spliceosome. Sequences within the pre-mRNA determine intron recognition and excision...
  74. doi Rs4948496 within ARID5B gene is associated with clinical features of systemic lupus erythematosus in the Chinese Han population
    Long Jiang
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, China
    J Dermatol 42:608-12. 2015
    ..03, OR = 0.81, 95% CI = 0.68-0.98) and anti-RNP (P = 0.03, OR = 0.86, 95% CI = 0.76-0.99)...
  75. pmc Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming
    Jun Yao
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, and Section of Molecular Genetics and Microbiology, School of Biological Sciences, The University of Texas at Austin, Austin, Texas, United States of America
    PLoS Genet 9:e1003469. 2013
    Mobile group II introns retrohome by an RNP-based mechanism in which the intron RNA reverse splices into a DNA site and is reverse transcribed by the associated intron-encoded protein...
  76. doi Electrophoretic mobility shift assay for characterizing RNA-protein interaction
    Keith T Gagnon
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 703:275-91. 2011
    ..Here we present a protocol for the practical use of EMSA to assess protein-RNA interactions and ribonucleoprotein (RNP) assembly...
  77. ncbi Alterations of heterogeneous nuclear RNP A2 and B1 in the hippocampus of the rat after perforant pathway lesion
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, 305 8575 Tsukuba city, Ibaraki, Japan
    Acta Neuropathol 107:144-8. 2004
    ..Our study further suggests that the functions of hnRNPA2 and B1 are different, as each was differentially involved in the plastic response to deafferentation of the perforant pathway...
  78. pmc Proteomic Analysis of Dhh1 Complexes Reveals a Role for Hsp40 Chaperone Ydj1 in Yeast P-Body Assembly
    Gregory A Cary
    Institute for Systems Biology, Seattle, Washington 98109 Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195
    G3 (Bethesda) 5:2497-511. 2015
    P-bodies (PB) are ribonucleoprotein (RNP) complexes that aggregate into cytoplasmic foci when cells are exposed to stress...
  79. doi Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus
    Erh Fang Hsieh
    Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan
    J Infect Dis 204:864-72. 2011
    ..The 2009 influenza A pandemic virus (H1N1(pdm)) may reassort with old seasonal influenza A virus (H1N1₁₄₁) in humans and potentially change their pathogenicity...
  80. doi Late-onset systemic lupus erythematosus: epidemiology, diagnosis and treatment
    Laurent Arnaud
    Department of Internal Medicine, French Reference Center for Systemic Lupus Erythematosus, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Drugs Aging 29:181-9. 2012
    ..of rheumatoid factor and of antinuclear antibody positivity, and a lower frequency of anti-ribonucleoprotein (anti-RNP) and anti-Sm antibody positivity...
  81. pmc Versatility of the translational machinery during stress: changing partners to keep dancing
    Fátima Gebauer
    Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation CRG UPF, Dr Aiguader 88, 08003 Barcelona, Spain
    Cell Res 22:1634-6. 2012
    ..In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.
  82. pmc Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways
    Koshi Imami
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
    Mol Cell Proteomics 11:1741-57. 2012
    ..protein-protein networks related to cytoskeletal organization and transcriptional/translational regulation, such as RNP complexes (i.e. hnRNP, snRNP, telomerase, ribosome), are linked to EGFR/HER2 signaling networks...
  83. pmc LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex
    John L Goodier
    Dept of Genetics, University of Pennsylvania School of Medicine, Rm 515 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:6469-83. 2007
    ..We suggest that targeting ORF1p, and possibly the L1 RNP, to stress granules is a mechanism for controlling retrotransposition and its associated genetic and cellular damage...
  84. doi Multiscale in situ analysis of the role of dyskerin in lung cancer cells
    Ignacio Fernandez-Garcia
    Oncology Division, Center for Applied Medical Research, CIMA, University of Navarra, Avda Pio XII 55, Pamplona 31008, Spain
    Integr Biol (Camb) 5:402-13. 2013
    Dyskerin is one of the three subunits of the telomerase ribonucleoprotein (RNP) complex. Very little is known about the role of dyskerin in the biology of the telomeres in cancer cells...
  85. pmc Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis
    Alexandra Viola Bohne
    Molecular Plant Sciences, Ludwig Maximilians University Munich, Planegg Martinsried, Germany
    PLoS Biol 11:e1001482. 2013
    ..Gel filtration analyses demonstrated an RNP complex containing DLA2 and the chloroplast psbA mRNA specifically in cells metabolizing acetate...
  86. pmc CRISPR-Cas systems in the cyanobacterium Synechocystis sp. PCC6803 exhibit distinct processing pathways involving at least two Cas6 and a Cmr2 protein
    Ingeborg Scholz
    Genetics and Experimental Bioinformatics Group, Faculty of Biology, University of Freiburg, Freiburg, Germany
    PLoS ONE 8:e56470. 2013
    ..These structures might interfere with the loading of the crRNAs into RNP complexes, explaining the varying abundancies...
  87. ncbi Pore-linked filaments in anura spermatocyte nuclei
    Maria Luiza Beçak
    Laboratorio de Genetica, Instituto Butantan, Sao Paulo, SP, 05503 900, Brasil
    An Acad Bras Cienc 79:63-70. 2007
    ..The intranuclear filaments are associated with chromatin fibers and related to RNP particles of 20-25 nm and spheroidal structures of 0.5 microm, with variations...
  88. pmc αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation
    Xinjun Ji
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 33:2560-73. 2013
    ..Here we assess the genome-wide impact of αCP RNA-protein (RNP) complexes on 3' processing with a specific focus on its role in alternative polyadenylation (APA) site utilization...
  89. ncbi Determination of ANA specificity using multiplexed fluorescent microsphere immunoassay in patients with ANA positivity at high titres after infliximab treatment: preliminary results
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Verona, Italy
    Rheumatol Int 27:649-54. 2007
    ..One patient affected by rheumatoid arthritis showed multiple ANA reactivities against SS-A, SS-B, RNP, Sm, Jo-1 and histones; one patient affected by ankylosing spondylitis resulted positive for the same ..
  90. pmc Differential regulation of mRNA stability controls the transient expression of genes encoding Drosophila antimicrobial peptide with distinct immune response characteristics
    Youheng Wei
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Nucleic Acids Res 37:6550-61. 2009
    ..of AMP mRNA and the RNA destabilizing protein transactor Tis11 as shown in co-immunoprecipitation of the Tis11 RNP complex with CecA1 mRNA but not other AMP mRNA...
  91. ncbi Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo
    Somashe Niranjanakumari
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Methods 26:182-90. 2002
    ..Inspired by the chromatin immunoprecipitation assay, we have developed a ribonucleoprotein (RNP) immunoprecipitation assay to study RNA-protein interactions in vivo...
  92. ncbi Molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro
    Sven Horke
    Heinrich Pette Institut für Experimentelle Virologie und Immunologie Universität Hamburg, Martinistrasse 52, Hamburg D 20251, Germany
    J Biol Chem 277:34949-58. 2002
    ..The data demonstrate that the first RRM is not required for binding, whereas the RNP-1 and RNP-2 consensus sequences of the RRM-2 and RRM-3 are separately required for binding, indicating a ..
  93. ncbi Interactions of a didomain fragment of the Drosophila sex-lethal protein with single-stranded uridine-rich oligoribonucleotides derived from the transformer and Sex-lethal messenger RNA precursors: NMR with residue-selective [5-2H]uridine substitutions
    I Kim
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Japan
    J Biomol NMR 17:153-65. 2000
    Proteins that contain two or more copies of the RNA-binding domain [ribonucleoprotein (RNP) domain or RNA recognition motif (RRM)] are considered to be involved in the recognition of single-stranded RNA, but the mechanisms of this ..
  94. ncbi micF RNA binds to the 5' end of ompF mRNA and to a protein from Escherichia coli
    J Andersen
    Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794
    Biochemistry 29:9249-56. 1990
    ..the first to demonstrate the complex between micF RNA and the 5' end of ompF mRNA and suggest that in vivo a micF ribonucleoprotein (RNP) particle may participate in the destabilization ompF mRNA during thermoregulation of OmpF porin.
  95. pmc The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing
    Hon Ren Huang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 23:8809-19. 2003
    ..In wild-type strains, p62 remains associated with the excised intron lariat RNA in ribonucleoprotein (RNP) particles that are essential for intron homing...
  96. pmc Mutational analysis of fibrillarin and its mobility in living human cells
    S Snaar
    Department of Molecular Cell Biology, Sylvius Laboratories, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    J Cell Biol 151:653-62. 2000
    ..The presence of the RNP domain seems to be a prerequisite for correct targeting of fibrillarin...
  97. ncbi Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains
    Finn C Nielsen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Cell Sci 115:2087-97. 2002
    ..GFP-IMP1 is present in large 200-700 nm RNP granules, which are distributed along microtubules...
  98. ncbi The insulin-like growth factor mRNA binding-protein IMP-1 and the Ras-regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells
    Roee Atlas
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Neurochem 89:613-26. 2004
    ..The tau mRNA is trafficked in an RNA-protein complex (RNP) from the neuronal cell body to the distal parts of the axon, reaching as far as the growth cone...
  99. ncbi Determinant spreading: lessons from animal models and human disease
    J McCluskey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Rev 164:209-29. 1998
    ..Immunisation of healthy mice with individual protein components of the La/Ro ribonucleoprotein (RNP) targeted in systemic lupus erythematosus and primary Sjögren's syndrome induced autoantibodies recognising Ro60 (..
  100. doi Systemic sclerosis: demographic, clinical and serological features in 100 Iranian patients
    Hadi Poormoghim
    Rheumatology Research Center, Firoozgar Hospital Tehran, Tehran University of Medical Sciences, Tehran, Iran
    Rheumatol Int 33:1943-50. 2013
    ..ANA such as anti-centromere antibodies (ACA), anti-topoisomerase (TOPO), anti-RNA polymerase III (Pol 3), anti-U3-RNP (U3-RNP), anti-Th/To (Th/To) and anti-PM/Scl (PM/Scl) were detected by line immunoassay and anti-U1-RNP (U1-RNP) by ..
  101. ncbi Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus
    T P Millard
    Department of Photobiology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 146:210-5. 2002
    The Ro 60 kDa protein (Ro60 or SSA2) is the major component of the Ro ribonucleoprotein (Ro RNP) complex, to which an immune response is a specific feature of several autoimmune diseases...

Research Grants65

  1. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2009
    ..and dynamic insights into how proteins modulate RNA structure and function in a catalytic ribonucleoprotein (RNP) complex...
  2. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Eric L Greidinger; Fiscal Year: 2011
    ..Immunity to snRNP autoantigens, including the Smith (Sm) and the U1-70RD polypeptide of the ribonucleoprotein (RNP) antigen, appears to have a central role in these diseases...
  3. Definition of Serum Ribonucleoprotein Composition and its Regulation and Function
    Thomas Tuschl; Fiscal Year: 2013
    ..exRNAs and their associated proteins in serum, investigate mechanisms leading to circulating ribonucleoprotein (RNP) homeostasis, and identify protein factors contributing to cellular RNA release...
  4. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2013
    ..Pre- mRNA splicing occurs in a ribonucleoprotein (RNP) complex called the spliceosome, which is composed of a large number of proteins and multiple U small nuclear RNP ..
  5. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The assembly of ribonucleoprotein (RNP) complexes into microscopically visible granules occurs as part of the normal cellular regulation of RNA metabolism (processing bodies) and in response to ..
  6. Defining the messenger RNP code in the brain
    EUGENE WEI MING YEO; Fiscal Year: 2013
    ..Finally, we will leverage our computational expertise to build predictive models using this genome-wide, multi-scale, mRNP code in the brain. ..
  7. Posttranscriptional regulation by mRNA-binding shuttling and transport proteins
    Thomas Tuschl; Fiscal Year: 2013
    ..ligands, will by co-crystallized with their respective recombinant proteins placing emphasis on obtaining larger RNP structures...
  8. Methods for purification of individual nuclear pre-messenger RNA-protein complexe
    Donald C Rio; Fiscal Year: 2013
    ..constellation of RNA binding proteins that a given transcript acquires to form a distinct ribonucleoprotein (RNP) complex will control its RNA processing, RNA export and RNA stability...
  9. Molecular and cellular characterization of SMN-mediated U7 snRNP assembly
    SARAH R TISDALE; Fiscal Year: 2013
    ..Our preliminary work identifies the assembly of the U7 snRNP - a RNP factor required for 3'-end processing of replication dependent histone mRNAs - as SMN-dependent in vivo...
  10. Mammalian Reovirus Post-transcriptional Gene Regulation
    CHARLES ROY MARTINEZ; Fiscal Year: 2010
    ..provide support for work which will focus on dissecting the structure-function relationships in ribonucleoprotein (RNP) complexes that mediate post-transcriptional gene regulation in viruses with double-strandedA (dsRNA) genomes...
  11. Protein-RNA Interactions in Biology and Disease
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ..of posttranscriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease...
  12. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..The assembly of HCV ribonucleoprotein complex (RNP) in response to TGF-21 will be examined by using two-step affinity purification of RNP complexes from HCV ..
  13. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    ..Our hypothesis is that SMN role in RNP assembly may extend to other cellular noncoding RNAs (ncRNAs), possibly with a motor neuron-specific expression ..
  14. The influenza A virus nucleoprotein: structure and function
    Yizhi Jane Tao; Fiscal Year: 2012
    ..eight segments of (-)RNA that are encapsidated in distinct double-helical structures called the ribonucleoprotein (RNP) complexes. The nucleoprotein (NP), the major protein component of RNPs, binds along genomic RNA at a 24nt interval...
  15. Structure and dynamics of the Tetrahymena telomerase ribonucleoprotein
    Michael D Stone; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The telomerase ribonucleoprotein (RNP) is required for maintaining telomeres, the specialized nucleoprotein structures that protect eukaryotic chromosome ends from aberrant processing and deleterious ..
  16. Translational regulation of cellular morphogenesis in early Drosophila embryos
    Paul M Macdonald; Fiscal Year: 2012
    ..regulation and that dFMRP and TRAL function during the MZT within dynamic cytoplasmic ribonucleoprotein (RNP) bodies (MZT bodies)...
  17. Kit for global RNP profiling
    RACHEL HAURWITZ; Fiscal Year: 2013
    ..To address this need, our Phase I goal is to develop a new and robust affinity separation technology for RNP complexes...
  18. Role of Lipids in Hepatitis C Virus Maturation
    Aleem Siddiqui; Fiscal Year: 2013
    ..HCV replicates its RNA genome within ribonucleoprotein complexes (RNP) consisting of viral and host cellular factors...
  19. Biogenesis and Regulation of Human Telomerase
    Kathleen Collins; Fiscal Year: 2013
    ..TER) is expressed as a precursor that must be processed, folded, and assembled as a stable ribonucleoprotein (RNP) complex in order to accumulate to detectable level in vivo...
  20. Biogenesis of Small Ribonucleoproteins
    A Gregory Matera; Fiscal Year: 2013
    ..Eukaryotic gene expression requires a constellation of small non-coding RNP particles that participate in multiple aspects of organismal function...
  21. Structure and Function of Human Telomerase
    JULI F FEIGON; Fiscal Year: 2013
    ..3'half contains the elements essential for localization, processing, TR accumulation, and binding the H/ACA RNP proteins...
  22. Functional characterization of piRNPs
    Zissimos Mourelatos; Fiscal Year: 2013
    ..Our understanding of gene expression regulation has changed radically with the discovery of ribonucleoprotein (RNP) complexes programmed with small RNAs...
  23. Biogenesis of H/ACA Ribonucleoproteins
    U Thomas Meier; Fiscal Year: 2013
    ..by one of over 150 unique H/ACA RNAs, each of which associates with the same four core proteins to form an H/ACA RNP. The central core protein NAP57 (aka dyskerin) is mutated in the predominant X-linked form of the inherited bone ..
  24. Structural studies of respiratory syncytial virus
    Elizabeth R Wright; Fiscal Year: 2013
    ..The M protein also orchestrates the incorporation of the viral glycoproteins and the ribonucleoprotein (RNP) into the evolving viral particles...
  25. Structure and Regulation of snoRNP Interaction with rRNA
    Hong Li; Fiscal Year: 2012
    ..Human telomerase is a specialized H/ACA RNP that exploits the H/ACA RNA domain for its localization and maturation...
  26. Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    TARIQ RANA; Fiscal Year: 2009
    ..P-TEFb is inactivated by sequestration into a large ribonucleoprotein (RNP) complex containing the small nuclear RNA, 7SK, and the Hexim1 protein...
  27. Mechanisms of innate immunity against HIV
    Tariq M Rana; Fiscal Year: 2013
    ..provided by applicant): The main goal of this work is to understand the role of small RNAs and ribonucleoprotein (RNP) complexes in creating innate immune response to viral infections...
  28. Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    Tariq M Rana; Fiscal Year: 2013
    ..P-TEFb is inactivated by sequestration into a large ribonucleoprotein (RNP) complex containing the small nuclear RNA, 7SK, and the Hexim1 protein...
  29. Mechanisms of mRNP remodeling in mRNA turnover
    Jens Lykke-Andersen; Fiscal Year: 2013
    ..Third, it will be tested whether ATPase activity of MOV10, a homolog of Upf1, is required for RNP remodeling during mRNA degradation activated by the RNA induced silencing complex (RISC) in complex with microRNAs...
  30. Cell growth control by cell and organelle size-dependent ribosome biogenesis
    Clifford P Brangwynne; Fiscal Year: 2012
    ..We recently introduced the novel concept that non-membrane bound ribonucleoprotein (RNP) bodies, including the ribosome-producing nucleolus, are dynamic liquid phase micro-reactors for rapid RNA ..
  31. Hepatitis delta virus RNA-protein complexes
    John L Casey; Fiscal Year: 2010
    ..The long-term objectives are to determine the structure of the HDV RNP and its specific roles in virus replication and packaging...
  32. Mechanisms directing oncoprotein and cytokine mRNA decay
    Gerald M Wilson; Fiscal Year: 2013
    ..to define the roles of specific molecular determinants in the formation of stable, functional ribonucleoprotein (RNP) complexes on AREs...
  33. Mechanism of RNA Localization in Drosophila Development
    Elizabeth R Gavis; Fiscal Year: 2013
    ..subcellular domains is a complex process involving the assembly and trafficking of large ribonucleoprotein (RNP) complexes...
  34. A new technology to isolate RNP complexes of a polycistronic miRNA oncogene
    Lin He; Fiscal Year: 2013
    ..More importantly, our technology can be easily adapted to study cancer related RNP complexes containing other ncRNA species...
  35. Nuclear bodies and ribonucleoprotein biogenesis
    Michael D Hebert; Fiscal Year: 2012
    ..body organization between different cell types is a manifestation of the most efficient nuclear configuration for RNP biogenesis...
  36. The regulation and function of cytoplasmic foci in quiescent cells
    Paul K Herman; Fiscal Year: 2013
    ..This proposal extends this analysis and examines a particular ribonucleoprotein (RNP) complex that forms in the cytoplasm of resting cells, known as a Processing-body, or P-body...
  37. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..immune response, and understand activity relationships of the surface glycoproteins (HA, NA) and ribonucleoprotein (RNP) complex, including the polymerase (PA, PB1, PB2), that underlie the pathogenicity and transmissibility of pandemic ..
  38. Examining the role of Cbk1/NDR kinase in regulating mRNA localization
    Francis C Luca; Fiscal Year: 2013
    ..Specifically, we have shown that Cbk1 phosphorylates the ribonucleoprotein (RNP) Ssd1 and promotes the polar localization of a subset of Ssd1-mRNA complexes, suggesting that NDR kinases promote ..
  39. Molecular Mechanisms of Rhabdovirus Entry
    Sean P J Whelan; Fiscal Year: 2013
    ..imaging approaches to probe the relationships between hemifusion, fusion pore formation and transfer of the RNP across a lipid bilayer in vitro...
  40. PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUS
    Westley H Reeves; Fiscal Year: 2013
    ..In mice with lupus caused by i.p. injection of tetramethylpentadecane (TMPD, pristane), anti-Sm/RNP and anti-DNA autoantibodies are induced and immune complex-mediated glomerulonephritis develops...
  41. Synergism of telomere maintenance and telomerase with cancer-promoting signaling
    Elizabeth H Blackburn; Fiscal Year: 2013
    ..involve not only the active reverse transcriptase-competent form of the full telomerase ribonucleoprotein (RNP), but also the abundantly expressed, yet poorly characterized, reverse transcriptase-incompetent b- splice variant ..
  42. Molecular Mechanisms of Rhabdovirus Entry
    Sean Whelan; Fiscal Year: 2009
    ..imaging approaches to probe the relationships between hemifusion, fusion pore formation and transfer of the RNP across a lipid bilayer in vitro...
  43. Nuclear export of RNAs by nuclear envelope budding
    VIVIAN G BUDNIK; Fiscal Year: 2013
    ..These studies are likely to be paradigm-shifting for our understanding of how and where large RNP transport granules are formed, which is elemental to the understanding of how the precise polarized assembly of ..
  44. Mechanisms of DFrizzled-RNP Nuclear Egress
    Rachel Maloney; Fiscal Year: 2013
    ..DFz2C localizes to prominent foci at the periphery of muscle nuclei, which associate with large ribonucleoprotein (RNP) granules...
  45. Assembly of the AI5-beta Group I Intron RNP
    Edward Turk; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): This proposal will elucidate the mechanisms of ribonucleoprotein (RNP) biogenesis...
  46. REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEAST
    RONALD BUTOW; Fiscal Year: 2007
    ..splicing, and in[unreadable] particular, to resolve excised group I introns from ribonucleoprotein[unreadable] (RNP) splicing complexes...
  47. Assembly and export of HIV messenger ribonucleoproteins
    JOHN ROBERT HOGG; Fiscal Year: 2010
    ..the precise step of mRNA maturation affected, allowing a hypothesis-driven investigtion of HIV mRNA processing and RNP assembly. The specific properties of the 3'LTR leading to N86-hnRNPU-sensitivity are unknown...
  48. RNase P as a Model for Ribonucleoprotein Assembly
    STACY CHAMBERLIN; Fiscal Year: 2005
    Ribonucleoprotein (RNP) complexes are integral to cellular function and control of RNP assembly is an important cellular regulatory mechanism and an attractive therapeutic target...
  49. FUNCTION OF THE FIBRILLARIN METHYLATED DOMAIN IN VIVO
    Mark Christensen; Fiscal Year: 1993
    Long term objectives include establishing the biological significance of the diverse nuclear ribonucleoprotein (RNP) particles which exist in eukaryotic cells and characterizing the functional/evolutionary relationships among certain ..
  50. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..to Sm and nRNP are apparently of high titer in that they precipitate in double immunodiffusion assays and bind RNP antigens in solution phase and by immunoblots. In essence, by immunizing rabbits with peptides, Dr. James and Dr...
  51. RNA Dynamics of Transient Macromolecular Complexes in Cancer Cells
    Jack D Keene; Fiscal Year: 2013
    ..While protein components of RNP granules have been studied in mammalian cells, quantitative RNA population dynamics have not been analyzed for lack ..
  52. Functions of 5'NCRs of picornavirus and cellular mRNAs
    Bert L Semler; Fiscal Year: 2013
    ..The experiments proposed in the third aim will examine the nature of RNP complexes formed with the 5'NCRs of these two cellular mRNAs to define the determinants of IRES functions for ..
  53. Coupling of Transcription with Pre-mRNA Metabolism
    DAVID LEONARD BENTLEY; Fiscal Year: 2013
    ..3. To determine how assembly of export competent RNP's is coordinated with processing of the mRNA by cleavage-polyadenylation...
  54. NUCLEAR PROTEINS AND AUTOIMMUNITY
    SALLIE HOCH; Fiscal Year: 1992
    ..Two such antigens have been designated Sm and RNP. Together these antigens are represented by at least 10 polypeptides, all of which are part of larger particles ..
  55. NUCLEAR ACIDIC PROTEIN ANTIGENS IN RHEUMATIC DISEASES
    GORDON SHARP; Fiscal Year: 1990
    ..Patient autoimmune antibodies directed against distinct antigens (RNP, Sm and Me) of the ubiquitous U1 small nuclear ribonucleoprotein particle (U1 snRNP) are strongly associated with ..
  56. Protein Arginine Methylation in Trypanosomes
    Laurie K Read; Fiscal Year: 2013
    ..for gene regulatory functions including trans splicing, translation initiation, and the formation of cytoplasmic RNP granules implicated in RNA turnover and translational control...
  57. Protein Arginine Methylation in Trypanosomes
    LAURIE READ; Fiscal Year: 2009
    ..for gene regulatory functions including trans splicing, translation initiation, and the formation of cytoplasmic RNP granules implicated in RNA turnover and translational control...
  58. CHARACTERIZATION OF RHEUMATOID ANTIGENS IN CYANOBACTERIA
    SHIRLEY KOVACS; Fiscal Year: 1991
    ..connective tissue disease (MCTD) patients produce autoantibodies directed against distinct antigenic sites (Sm and RNP respectively) on the ubiquitous U1 small nuclear ribonucleoprotein particle (U1snRNP or U1RNP) of eucaryotic cells...
  59. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
    ..This is the first step toward deciphering the 'RNP code'for PMR1-mRNA decay...
  60. Expression control in Drosophila splicing assembly factor RNP-4F
    JACK VAUGHN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Drosophila RNP-4F is an ortholog to human p110, which functions with the pre-mRNA processing (PRP) protein class as a recycling factor to carry U4- and U6-snRNPs to the assembling spliceosome...
  61. Dysregulation of VEGF RNA Stability in Amyotrophic Lateral Sclerosis
    Liang Lu; Fiscal Year: 2012
    ..Second, we will analyze the interaction between mutant SOD1 proteins, HuR and the RNP complex associated with the VEGF 3'UTR to determine why mutant SOD1 negatively affects VEGF RNA processing...
  62. Kinetoplastid SL RNA biogenesis
    David A Campbell; Fiscal Year: 2013
    ..Using the SmD3 protein, the SL RNA RNP complex and associated splicing machinery, both catalytic and core, has been captured...
  63. TELOMERASE RNP STRUCTURE/FUNCTION
    DOROTHY SHIPPEN; Fiscal Year: 2001
    ..The primary mechanism for synthesizing teleomeres is telomerase, an unusual ribonucleoprotein (RNP) with reverse transcriptase activity...
  64. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    ..A critical early step in HBV replication is the assembly of a specific ribonucleoprotein (RNP) complex between the viral reverse transcriptase (RT) and a specific RNA signal called Epsilon, located at the 5&..
  65. IMMUNE MECHANISMS IN PRISTANE INDUCED LUPUS NEPHRITIS
    Westley Reeves; Fiscal Year: 2003
    ..This syndrome is characterized by disease-specific autoantibody production (anti-Sm, RNP, Su, ribosomal P, double stranded DNA), hypergammaglobulinemia, and severe immune complex-mediated ..