RNPC3

Summary

Gene Symbol: RNPC3
Description: RNA binding region (RNP1, RRM) containing 3
Alias: RBM40, RNP, SNRNP65, RNA-binding protein 40, RNA-binding motif protein 40, RNA-binding region-containing protein 3, U11/U12 small nuclear ribonucleoprotein 65 kDa protein, U11/U12 snRNP 65 kDa protein, U11/U12 snRNP 65K, U11/U12-65K
Species: human

Top Publications

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
  3. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
  4. pmc The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein
    Heike Benecke
    Department of Cellular Biochemistry, MPI of Biophysical Chemistry, Gottingen, Germany
    EMBO J 24:3057-69. 2005
  5. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
  6. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
  7. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
  8. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
  9. doi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
  10. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997

Research Grants

  1. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2009
  2. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Eric L Greidinger; Fiscal Year: 2011
  3. Thomas Tuschl; Fiscal Year: 2016
  4. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2013
  5. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
  6. EUGENE WEI MING YEO; Fiscal Year: 2016
  7. Thomas Tuschl; Fiscal Year: 2016
  8. Methods for purification of individual nuclear pre-messenger RNA-protein complexe
    Donald C Rio; Fiscal Year: 2013
  9. Mammalian Reovirus Post-transcriptional Gene Regulation
    CHARLES ROY MARTINEZ; Fiscal Year: 2010
  10. SARAH R TISDALE; Fiscal Year: 2014

Detail Information

Publications274 found, 100 shown here

  1. ncbi Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?
    J Kiljanski
    The Thyroid Eye Disease Research Laboratory, Allegheny Singer, Research Institute, Pittsburgh, USA
    Horm Metab Res 27:528-32. 1995
    ..a fine speckled fluorescence, found in 45% of sera, consistent with reactivity against the Sm antigen or nuclear RNP. The finding of a high prevalence of ANA and, less often, anti-connective tissue antibodies in patients with ..
  2. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
    ..examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution...
  3. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..Only sera from DR3 and DQ0604 mice immunoprecipitated A-ribonucleoprotein (RNP), SmB, and SmD...
  4. pmc The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein
    Heike Benecke
    Department of Cellular Biochemistry, MPI of Biophysical Chemistry, Gottingen, Germany
    EMBO J 24:3057-69. 2005
    ..Taken together, these data suggest that U11/U12-65K and U11-59K contribute to di-snRNP formation and intron bridging in the minor prespliceosome...
  5. ncbi Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure
    W Forrester
    Department of Biochemistry, College of Agricultural and Life Sciences, Madison, Wisconsin 53706
    Genes Dev 6:1914-26. 1992
    ..We speculate that the perturbations in mRNA processing are the result of effects on the chromatin-nascent RNP-transcription complex or misregulation of a cell cycle component that modifies multiple mRNA-processing activities.
  6. ncbi Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells
    O M Echeverria
    Laboratory of Electron Microscopy, Faculty of Sciences, D F, Mexico
    Ultrastruct Pathol 22:185-97. 1998
    ..Some nucleoli were surrounded by a double fibrillar layer limiting a perinucleolar space occupied by RNP fibrogranular structures that differed from those of normal nuclei...
  7. ncbi Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer
    Ahmed Al-Shukaili
    Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman
    Saudi Med J 27:1873-7. 2006
    ..To investigate the prevalence of a group of different autoantibodies, in Omani patients with gastric cancer, and to examine whether their presence correlates with clinical course of the disease...
  8. ncbi Molecular biological ontogenesis of the thymic reticulo-epithelial cell network during the organization of the cellular microenvironment
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, USA
    In Vivo 13:267-94. 1999
    ..Their cytoplasm occasionally displays RNP granules, and is rich in non-histone proteins, fine phospholipid, lipid or cholesterin granules, and vacuoles ..
  9. doi [How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies]
    Jean Sibilia
    CHU de Strasbourg, Hopital Hautepierre, Service de Rhumatologie, Laboratoire d Immunologie, 67098 Strasbourg Cedex, France
    Presse Med 39:1010-25. 2010
    ..These auto-antibodies are directed against nuclear or nucleolar auto-antigens: the anti-PM-Scl, anti-Ku, anti-RNP (U1 RNP and U2 RNP, U4/U6 RNP and U5 RNP), anti-Ro 52 kDa and more rarely, anti-Ro 60 kDa and anti-La...
  10. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997
    ..Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases...
  11. pmc Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein
    M J Matunis
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104 6148
    Mol Cell Biol 12:164-71. 1992
    At least 20 major proteins make up the ribonucleoprotein (RNP) complexes of heterogeneous nuclear RNA (hnRNA) in mammalian cells. Many of these proteins have distinct RNA-binding specificities...
  12. pmc Investigating the specificity and stoichiometry of RNA binding by the nucleocapsid protein of Bunyamwera virus
    Bjorn Patrick Mohl
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS29JT, West Yorkshire, United Kingdom
    RNA 15:391-9. 2009
    ..along their entire lengths with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex...
  13. ncbi Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme
    Shin Kawano
    Laboratory of Biochemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    J Mol Biol 357:583-91. 2006
    ..beta-sheet and five helices, which fold in a way that is topologically similar to the ribonucleoprotein (RNP) domain...
  14. ncbi [Low prevalence of anti-centromere antibodies in scleroderma in Morocco (about 272 cases)]
    B Admou
    Faculte de Medecine, Marrakech, Morocco
    Ann Biol Clin (Paris) 65:291-7. 2007
    ..assessment of autoantibodies prevalence during scleroderma within a Moroccan population by a retrospective survey...
  15. ncbi Neonatal lupus erythematosus: an unusual congenital presentation with cutaneous atrophy, erosions, alopecia, and pancytopenia
    E Crowley
    University of Illinois, College of Medicine, Urbana, USA
    Pediatr Dermatol 15:38-42. 1998
    ..Ro, La, and RNP antibodies were absent, and the diagnosis was made because of light microscopic and immunofluorescent findings...
  16. doi Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China
    Xuhua Tang
    Department of Dermatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Medicine (Baltimore) 89:62-7. 2010
    ..with higher prevalence of malar rash/discoid rash, pericarditis, and leukopenia; anti-ribonucleoprotein (anti-RNP) with higher prevalence of Raynaud phenomenon and photosensitivity; anti-deoxyribonucleoprotein (anti-DNP) with ..
  17. ncbi Age-correlated changes in the lupus erythematosus antigens Ro, La, Sm and RNP of the thymus gland
    W E Muller
    Institut fur Physiologische Chemie, Universitat, Mainz, West Germany
    Compr Gerontol A 1:40-4. 1987
    The concentrations of the Sm, RNP, La and Ro antigens of thymus glands from rats were determined depending on the developmental stage of the animals. It was found that lupus antigens strongly decrease after birth...
  18. pmc Development of recombinant nucleoprotein-based diagnostic systems for Lassa fever
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Clin Vaccine Immunol 14:1182-9. 2007
    ..for the detection of LASV antibodies and LASV antigens, were developed using the recombinant nucleoprotein (rNP) of LASV (LASV-rNP). The LASV-rNP was expressed in a recombinant baculovirus system...
  19. ncbi Atypical autoantibodies in patients with primary Sjögren syndrome: clinical characteristics and follow-up of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 35:312-21. 2006
    ..To analyze the clinical characteristics, follow-up, and fulfillment of classification criteria for other systemic autoimmune diseases (SAD) in patients with primary Sjögren syndrome (SS) and atypical autoantibodies...
  20. ncbi The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis
    R Hesselstrand
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Rheumatology (Oxford) 42:534-40. 2003
    ..To study the frequency and specificity of antinuclear antibodies (ANA) and their association with internal organ involvement and survival in systemic sclerosis (SSc)...
  21. ncbi Anti-extractable nuclear antigens (ENA) antibodies in patients with chronic hepatitis C before and after treatment with interferon
    Katsuhisa Omagari
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Autoimmunity 36:269-73. 2003
    ..hepatitis C and 44 patients with non-hepatitis C virus (HCV) infected liver diseases were tested for anti-ENAs (U1 RNP, Sm, Ro/SS-A, La/SS-B and Scl-70) antibodies by enzyme-linked immunosorbent assay (ELISA)...
  22. ncbi [Resistance to the action of atrial natriuretic peptide and urodilatin in Heymann nephritis in vitro]
    J P Valentin
    Department of Medicine, San Francisco General Hospital, CA, USA
    Arch Mal Coeur Vaiss 87:1125-9. 1994
    ..glomeruli and inner medullary collecting duct (IMCD) cells in response to increasing concentration of ANP, and RNP (also called urodilatin). Results (fmol/mg prot/10 min) are means +/- SEM: [table: see text]...
  23. doi Infectious Bursal disease virus: ribonucleoprotein complexes of a double-stranded RNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, C Darwin No 3, Cantoblanco, E 28049 Madrid, Spain
    J Mol Biol 386:891-901. 2009
    ..dsRNA viruses nevertheless lack these ribonucleoprotein (RNP) complexes and are characterized by sharing an icosahedral T=2 core involved in the metabolism and insulation of ..
  24. ncbi High level expression of recombinant mumps nucleoprotein in Saccharomyces cerevisiae and its evaluation in mumps IgM serology
    Dhanraj Samuel
    Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, United Kingdom
    J Med Virol 66:123-30. 2002
    ..for mumps serology a high-level yeast expression system was employed to produce recombinant mumps nucleoprotein (rNP). The rNP was purified by CsCl gradient centrifugation and yielded approximately 15 mg/l of yeast culture...
  25. ncbi A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen
    Eric L Greidinger
    Division of Rheumatology and Immunology, University of Miami, Miami, Florida 33136, USA
    Arthritis Rheum 54:661-9. 2006
    ..To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE)...
  26. pmc Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex
    M Kiledjian
    Department of Cell, Developmental and Neurobiology, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Cell Biol 17:4870-6. 1997
    ..is an important regulatory component of gene expression and is significantly influenced by ribonucleoprotein (RNP) complexes which form on the mRNA...
  27. ncbi Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?
    C H To
    division of Rhumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 52:4003-10. 2005
    ..To examine autoantibody clusters and their associations with clinical features and organ damage accrual in patients with systemic lupus erythematosus (SLE)...
  28. pmc Childhood-onset systemic lupus erythematosus: a comparative study of African Americans and Latin Americans
    A Gedalia
    Department of Pediatrics, LSU Medical Center, New Orleans 70112 2822, USA
    J Natl Med Assoc 91:497-501. 1999
    ..In addition, there was a higher frequency of anti-dsDNA, anti-Sm, anti-RNP, and anti-Ro positivity among African-Americans compared with Latin-American patients...
  29. ncbi Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase
    R Rajpurohit
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
    J Biol Chem 269:1075-82. 1994
    ....
  30. doi Specific humoral reaction of hemorrhagic fever with renal syndrome (HFRS) patients in China to recombinant nucleocapsid proteins from European hantaviruses
    H R Xiong
    State Key Laboratory of Virology Institute of Medical Virology, School of Medicine, Wuhan University, 185 DongHu Road, Wuhan 430071, PR China
    Eur J Clin Microbiol Infect Dis 30:645-51. 2011
    ..The results showed that the sensitivity of rNPs against IgG was HTNV-rNP > DOBV-rNP > PUUV-rNP, while the sensitivity against IgA was DOBV-rNP > HTNV-rNP > PUUV-rNP...
  31. ncbi Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes
    G Schlenstedt
    Zentrum Biochemie/Abt. Biochemie II, , Germany
    J Biol Chem 267:24328-32. 1992
    ..We investigated the role of the precursor structure with respect to competence for RNP-independent transport by constructing deletion mutants and hybrid proteins...
  32. ncbi C-reactive protein reacts with the U1 small nuclear ribonucleoprotein
    T W Du Clos
    Department of Medicine, VA Medical Center, Albuquerque, New Mexico 87108
    J Immunol 143:2553-9. 1989
    ..Double staining with anti-RNP serum and CRP produced very similar staining patterns...
  33. doi Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features
    Shyamasri Biswas
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States
    Biochemistry 50:2907-18. 2011
    Box C/D ribonucleoproteins (RNP) guide the 2'-O-methylation of targeted nucleotides in archaeal and eukaryotic rRNAs. The archaeal L7Ae and eukaryotic 15...
  34. pmc Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo
    B Dichtl
    EMBL, Gene Expression Programme, Heidelberg, Germany
    EMBO J 16:417-29. 1997
    RNase MRP is a ribonucleoprotein (RNP) particle which is involved in the processing of pre-rRNA at site A3 in internal transcribed spacer 1...
  35. ncbi Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using electron paramagnetic resonance spectroscopy
    V Gopalan
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 38:1705-14. 1999
    Ribonuclease P (RNase P) is a catalytic ribonucleoprotein (RNP) essential for tRNA biosynthesis. In Escherichia coli, this RNP complex is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C5 protein...
  36. ncbi Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 168:5326-32. 2002
    ..Ab responses, we immunized A/J mice with recombinant Smith D (SmD), Smith B (SmB), and A ribonucleoprotein (A-RNP) with alum as adjuvant...
  37. pmc An umbraviral protein, involved in long-distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes
    Michael Taliansky
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
    J Virol 77:3031-40. 2003
    ..of the TMV CP [TMV(ORF3)], in infected cells it interacted with the TMV RNA to form filamentous ribonucleoprotein (RNP) particles that had elements of helical structure but were not as uniform as classical virions...
  38. pmc Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata
    Steffan W Schulz
    Division of Rheumatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Semin Arthritis Rheum 39:410-6. 2010
    ....
  39. doi pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances
    Toru Yoshitomi
    Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, 305 8573, Ibaraki, Japan
    Bioconjug Chem 20:1792-8. 2009
    For the imaging of low pH circumstances in vivo, a pH-sensitive radical-containing-nanoparticle (RNP), which has an intense electron paramagnetic resonance (EPR) signal, was designed and developed using a self-assembling amphiphilic ..
  40. ncbi Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: a study combining anterograde tracing with immunogold labeling in the rat
    C Schwarz
    Sektion fur Visuelle Sensomotorik, Neurologische Universitätsklinik Tübingen, Germany
    J Comp Neurol 381:320-34. 1997
    ..that of cerebellonuclear terminals in two other target structures, the parvocellular part of the nucleus ruber (RNp) and the ventromedial and ventrolateral thalamus (VM/VL)...
  41. ncbi Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    J Rheumatol 28:2454-9. 2001
    ..To evaluate the independent contribution of several clinical and laboratory variables to the mortality of a cohort of Danish patients with systemic sclerosis (SSc)...
  42. pmc The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex
    Gopal P Patel
    Department of Molecular and Cellular Biology, University of Guelph Guelph, Ontario, Canada, N1G 2W1
    Nucleic Acids Res 33:7074-89. 2005
    ..Using a modified ribonucleoprotein (RNP) immunoprecipitation procedure we further show that indeed, both IMP1 and UNR bind to the ARS containing reporter ..
  43. pmc Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons
    Honglai Zhang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:8622-32. 2006
    ..In immortalized non-neuronal cell lines, SMN has been shown to form a ribonucleoprotein (RNP) complex with Gemin proteins, which is essential for the assembly of small nuclear RNPs (snRNPs)...
  44. ncbi RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts
    Jack D Keene
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Protoc 1:302-7. 2006
    ..which mRNAs associate, nor can they be used to elucidate the dynamic composition of RNAs in ribonucleoprotein (RNP) complexes in response to physiological stimuli...
  45. ncbi [Study on the recombinant expression of Hantaan virus protein N and the establishment and application of rNP-IgM direct capture ELISA]
    Han ping Zhu
    Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:692-6. 2007
    ..NP) of hantavirus strain Z10 (HV-Z10), to construct its prokaryotic expression system as well as to establish a rNP-IgM direct capture ELISA based on HRP-labeled recombinant NP (rNP), in order to detect serum samples of patients ..
  46. doi Development of the human parvocellular red nucleus. A morphological study
    Katsuyuki Yamaguchi
    Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan
    Dev Neurosci 30:325-30. 2008
    Morphology of the human parvocellular red nucleus (RNp) was investigated in 14 fetuses aged from 12 to 39 weeks of gestation (WG). The brains were processed into celloidin-embedded serial sections...
  47. pmc A polypyrimidine tract binding protein, pumpkin RBP50, forms the basis of a phloem-mobile ribonucleoprotein complex
    Byung Kook Ham
    Department of Plant Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Plant Cell 21:197-215. 2009
    RNA binding proteins (RBPs) are integral components of ribonucleoprotein (RNP) complexes and play a central role in RNA processing. In plants, some RBPs function in a non-cell-autonomous manner...
  48. pmc Evidence for different contributions of archaea and bacteria to the ammonia-oxidizing potential of diverse Oregon soils
    Anne E Taylor
    Department of Crop and Soil Science, 3017 ALS, Oregon State University, Corvallis, OR 97331, USA
    Appl Environ Microbiol 76:7691-8. 2010
    ..inactivate ammonia monooxygenase, and upon the removal of acetylene, the recovery of nitrification potential (RNP) was monitored in the presence and absence of bacterial or eukaryotic protein synthesis inhibitors...
  49. ncbi Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction
    K B Elkon
    Hospital for Special Surgery, Cornell Medical Center, New York, NY 10021
    J Immunol 145:636-43. 1990
    SmB and SmB' are the major antigenic proteins contained within small nuclear RNP particles that are recognized by both human SLE and MRL mouse anti-Sm sera...
  50. ncbi Incorporation of argyrophilic proteins into the nucleolus-associated chromatin caused by exposure to actinomycin D
    S Sato
    Department of Biology, Faculty of Science, Ehime University, Japan
    Biol Cell 63:19-26. 1988
    ..is formed, detailed observations were carried out on thin sections following silver staining and ribonucleoprotein (RNP) preferential staining...
  51. pmc HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS)
    M Rischmueller
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre and Flinders University of South Australia
    Clin Exp Immunol 111:365-71. 1998
    ..explained by intermolecular spreading of autoimmunity toward different components of the La/Ro ribonucleoprotein (RNP)...
  52. ncbi Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods
    Sophie Desplat-Jego
    Laboratoire d Immunologie, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1109:245-55. 2007
    ..detection of antibodies against the following antigens: dsDNA, chromatin, SSA-52 kDa, SSA-60 kDa, SSB, Sm, Sm/RNP, RNP-A, RNP-68 kDa, Scl70, centromere B, Jo-1, and P ribosomal proteins...
  53. ncbi In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen
    Kindra M Kelly-Scumpia
    University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 56:3379-86. 2007
    ..This study was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo...
  54. doi Determination of protein-RNA interaction sites in the Cbf5-H/ACA guide RNA complex by mass spectrometric protein footprinting
    Daniel L Baker
    Department of Biochemistry and Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 47:1500-10. 2008
    ..In eukaryotes and archaea, these modifications are carried out by H/ACA ribonucleoprotein (RNP) complexes, composed of an H/ACA guide RNA and four proteins, including the pseudouridine synthase, Cbf5...
  55. doi Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation
    Alvaro D Ortega
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa CBMSO, CSIC UAM, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, ISCIII, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Cell Sci 123:2685-96. 2010
    ..the mitochondrial H(+)-ATP synthase subunit beta (ATP5B, beta-F1-ATPase) is localized in a large ribonucleoprotein (RNP) complex (beta-F1-RNP), which is subjected to stringent translational control during development and the cell cycle,..
  56. ncbi Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide
    K Yamamoto
    Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 140:311-7. 1988
    ..vector lambda gt11 after screening with a patient's serum containing a high titer of anti-ribonucleoprotein (RNP) antibodies...
  57. ncbi [Extrachromosomal structures containing small nuclear RNP and coilin in the late vitellogenic oocytes of hibernating grass frogs]
    A G Tsvetkov
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 44:1037-45. 2002
    ..were also positively stained with antibodies against Sm-epitope and trimetylguanosine cap of small nuclear (sn) RNP. According to the results of in situ nucleic acid hybridization, the nucleoli contain U6 snRNA...
  58. doi Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein
    J Hepojoki
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    J Gen Virol 91:2341-50. 2010
    Here we characterize the interaction between the glycoproteins (Gn and Gc) and the ribonucleoprotein (RNP) of Puumala virus (PUUV; genus Hantavirus, family Bunyaviridae)...
  59. ncbi Multiple plant RNA binding proteins identified by PCR: expression of cDNAs encoding RNA binding proteins targeted to chloroplasts in Nicotiana plumbaginifolia
    M Mieszczak
    Friedrich Miescher Institut, Basel, Switzerland
    Mol Gen Genet 234:390-400. 1992
    ..90 amino acids with a characteristic ribonucleoprotein consensus sequence (RNP-CS). A PCR approach that is suitable for the characterization of RNP-CS-type proteins is described...
  60. pmc Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes
    Alexis J Rodriguez
    Department of Biological Sciences, Rutgers University, 101 Warren Street, 135 Smith Hall, Newark, NJ 07102, USA
    RNA 11:646-56. 2005
    ..Seawi is a major component of microtubule-ribonucleoprotein (MT-RNP) complexes isolated from two different species of sea urchin, Strongylocentrotus purpuratus and Paracentrotus ..
  61. ncbi Autoantibodies in systemic sclerosis
    Virginia D Steen
    Department of Medicine, Georgetown University, Washington, DC 2007, USA
    Semin Arthritis Rheum 35:35-42. 2005
    ..To describe the clinical, laboratory, and prognostic features associated with the scleroderma-specific autoantibodies...
  62. ncbi The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems
    G N Andrianov
    Laboratory of Physiology of Reception, Pavlov Institute of Physiology, Russian Academy of Sciences, nab Makarova 6, St Petersburg 199034, Russia
    Hear Res 230:1-8. 2007
    ..study investigated the electrophysiological effects of externally applied human and rabbit defensins (HNP-1 and RNP-1, correspondingly) on afferent neurotransmission in the frog semicircular canals (SCC)...
  63. pmc Endothelial cell-binding activity of anti-U1-ribonucleoprotein antibodies in patients with connective tissue diseases
    M Okawa-Takatsuji
    Division of Clinical Immunology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Clin Exp Immunol 126:345-54. 2001
    In order to elucidate the immunological properties of anti-U1-ribonucleoprotein (RNP) antibody, one of the autoantibodies detected in patients with connective tissue diseases (CTDs), we tested the endothelial cell-binding by anti-U1-RNP ..
  64. pmc GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program
    Kyung Won Kim
    Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 107:17445-50. 2010
    ..One GLD-2 partner, RNP-8, was previously shown to influence oocyte fate specification...
  65. pmc Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA
    C Lutz-Freyermuth
    Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 87:6393-7. 1990
    Many RNA-associated proteins contain a ribonucleoprotein (RNP) consensus octamer encompassed by a conserved 80 amino acid sequence, which we have termed an RNA recognition motif (RRM)...
  66. ncbi Purification of Drosophila hsp 83 and immunoelectron microscopic localization
    M E Carbajal
    Centre de Recherche du CHUL, Centre Hospitalier Universite Laval, Sainte Foy, Quebec, Canada
    Eur J Cell Biol 52:147-56. 1990
    ..albeit at a lower level, in the nucleus where it is found within the network of perichromatin ribonucleoprotein (RNP) fibrils...
  67. pmc Cloning of the human cDNA for the U1 RNA-associated 70K protein
    H Theissen
    EMBO J 5:3209-17. 1986
    Anti-RNP sera were used to isolate a cDNA clone for the largest polypeptide of the U1 snRNP, a protein of mol. wt 70 kd designated 70K, from a human liver cDNA library constructed in the expression vector pEX1...
  68. ncbi The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo
    P Loyer
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Cell Sci 111:1495-506. 1998
    ..These data indicate that the PITSLRE p110 isoforms interact with RNPS1 in vivo, and that these proteins may in turn influence some aspect of transcriptional and/or splicing regulation...
  69. ncbi Terminal differentiation of erythroblasts leads to RNP segregation and formation of heterogeneous ectopic RNP-derived structures
    M Biggiogera
    Dipartimento di Biologia Animale, Centro di Studio per l Istochimica del CNR, University of Pavia, Italy
    Histochem Cell Biol 112:473-7. 1999
    ..We show an as yet unnoticed feature of mammalian erythrocyte maturation, i.e., the formation of heterogeneous ectopic RNP-derived structures in the nucleus of erythroblasts, occurring in parallel with chromatin condensation...
  70. pmc The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
    A Bachi
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 6:136-58. 2000
    ..TAP with nucleoporins, its direct binding to the CTE RNA, and its association with two mRNP binding proteins suggest that TAP is an RNA export mediator that may bridge the interaction between specific RNP export substrates and the NPC.
  71. ncbi Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin
    K W Jones
    Department of Biochemistry, University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 276:38645-51. 2001
    ..Our results suggest a function for SMN in small nucleolar RNP biogenesis (akin to its known role as an snRNP assembly factor) and reveal a potential link between small nucleolar ..
  72. ncbi Subcellular redistribution of la/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: a clue to the pathogenesis of congenital heart block
    Hai B Tran
    Flinders Medical Centre, Flinders University, Adelaide, Australia
    Arthritis Rheum 46:202-8. 2002
    ..heart block, the mechanism by which maternal autoantibodies target the intracellular components of the Ro/La RNP complex is unclear...
  73. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..VSV is required to induce activation of the IKK-related kinases and provide evidence that ribonucleoprotein (RNP) complex of VSV generated intracellularly during virus replication can activate TBK1 and IKKepsilon activity...
  74. pmc The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability
    Xialu Li
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    RNA 13:2108-15. 2007
    ..and RNPS1 cannot compensate for ASF/SF2 function in splicing, our data suggest that RNPS1 is able to function together with ASF/SF2 to form RNP complexes on nascent transcripts, and thereby prevent formation of transcriptional R-loops.
  75. doi In-vitro radiosensitivity in patients with systemic lupus erythematosus
    P L Carrillo-Alascio
    Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Lupus 18:645-9. 2009
    ..with anaemia, increased erythrocyte sedimentation rate and those with positive result for anti-La/SSB and anti-RNP antibodies showed significantly higher DNA double-strand breaks than those without them...
  76. pmc Conservation of telomere protein complexes: shuffling through evolution
    Benjamin R Linger
    Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Crit Rev Biochem Mol Biol 44:434-46. 2009
    ..In some cases, complex components appear to have migrated between the telomere and the telomerase RNP. Finally, gene duplication has created telomere protein paralogs with novel functions...
  77. pmc Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense
    Ai Harashima
    Department of Medicine, University of Miami School of Medicine, Florida 33136, USA
    Genes Dev 24:2640-53. 2010
    ..with dsRNA (NFAR1 [90 kDa] and NFAR2 [110 kDa]), which constitute part of the shuttling ribonuclear protein (RNP) complex...
  78. doi RNA-binding protein immunopurification-microarray (RIP-Chip) analysis to profile localized RNAs
    Alessia Galgano
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Methods Mol Biol 714:369-85. 2011
    ..RIP-Chip, has also been applied to identify mRNAs that are transported to distinct subcellular compartments by RNP-motor complexes...
  79. pmc Evolutionary conservation of the functional modularity of primate and murine LINE-1 elements
    Bradley J Wagstaff
    Tulane Cancer Center, Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e19672. 2011
    ..loss of function is physically separate from the cysteine-rich motif sequence previously shown to be required for RNP formation...
  80. pmc The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic
    Hélène Walbott
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, Universite de Paris Sud, Orsay Cedex, France
    Genes Dev 25:2398-408. 2011
    ..We propose that Shq1p operates as a Cbf5p chaperone during RNP assembly by acting as an RNA placeholder, thereby preventing Cbf5p from nonspecific RNA binding before association ..
  81. doi Screening of genes related to sulfide metabolism in Urechis unicinctus (Echiura, Urechidae) using suppression subtractive hybridization and cDNA microarray analysis
    Xiaoli Shi
    Key Laboratory of Marine Genetics and Breeding Ocean University of China, Ministry of Education, Qingdao 266003, China
    Comp Biochem Physiol Part D Genomics Proteomics 7:254-9. 2012
    ..Eight genes, serase, vacuolar protein, src tyrosine kinase, sulfide oxidase-like oxidoreductase, aprataxin, SN-RNP, aminopeptidase, and predicted protein, were selected to verify expression in the worm using qRT-PCR...
  82. pmc MS2-TRAP (MS2-tagged RNA affinity purification): tagging RNA to identify associated miRNAs
    Je Hyun Yoon
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Methods 58:81-7. 2012
    ..After affinity pulldown of the ribonucleoprotein (RNP) complex comprising [MS2-GST/lincRNA-p21-MS2], the RNA in the pulldown material was isolated and reverse ..
  83. ncbi Nitroxide radicals and nanoparticles: a partnership for nanomedicine radical delivery
    Yukio Nagasaki
    Department of Materials Science, Graduate School of Pure and Applied Science, Master s School of Medical Science, National Institute for Materials Science, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8573, Japan
    Ther Deliv 3:165-79. 2012
    ..Nitroxide radical-containing nanoparticles (RNP) shows high safety, long blood circulation, magnetic resonance imaging and ESR imaging sensitive character and ..
  84. doi Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells
    Patchima Sithisarn
    Institute for Medical Virology, Clinics of the Goethe University, Frankfurt am Main, Germany
    Antiviral Res 97:41-8. 2013
    ..01), virus-induced caspase 3 cleavage, nuclear export of viral RNP complexes, and enhanced the effects of the neuraminidase inhibitor zanamivir...
  85. doi A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice
    Fu Gang Zhu
    Idera Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Autoimmunity 46:419-28. 2013
    ..NZBW/F1 mice treated with the antagonist had lower serum levels of autoantibodies targeting DNA, RNP, Smith antigen, SSA and SSB than did untreated mice...
  86. doi Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus
    Xun Gui
    National Institute of Diagnostics and Vaccine Development in Infectious Disease, State Key Laboratory of Cellular Stress Biology, School of Life Science, Xiamen University, Xiamen, China
    J Med Virol 86:995-1002. 2014
    ..In this study, a recombinant NP (rNP) of influenza A virus was over-expressed and used to generate a panel of anti-NP mAbs...
  87. doi Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus
    Zhuo Zhou
    1 MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P R China 2
    Nat Commun 5:3259. 2014
    The ribonucleoprotein (RNP) of the influenza A virus is responsible for the transcription and replication of viral RNA in the nucleus. These processes require interplay between host factors and RNP components...
  88. doi [Connective tissue diseases in hospital practice in Ouagadougou (Burkina Faso)]
    D D Ouédraogo
    Service de Medecine Interne, centre hospitalier universitaire Yalgado, Ouagadougou, Burkina Faso
    Med Sante Trop 24:271-4. 2014
    ..The specific auto-antibodies associated with SLE patients were: anti-native DNA (3/6), anti-Sm (3/6), anti-RNP (3/6), and anti-SSA (4/6); anti-Scl 70 antibodies were present in 5 patients with ScS...
  89. pmc Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery
    Ching Chun Yang
    Taiwan International Graduate Program TIGP in Molecular Medicine, National Yang Ming University and Academia Sinica, Taipei, Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    PLoS ONE 9:e106683. 2014
    ..that NXF1-p15 heterodimer can serve as a major export receptor of nuclear mRNA as a ribonucleoprotein complex (RNP)...
  90. pmc The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication
    Takahito Kashiwagi
    Department of Infection Control and Prevention, Kurume University School of Medicine, Fukuoka, Japan
    PLoS ONE 9:e114502. 2014
    ..three subunits (PB1, PB2 and PA subunit), which assemble with nucleoproteins (NP) and a viral RNA (vRNA) to form a RNP complex in the host nucleus...
  91. doi Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice
    Hartinio N Nahampun
    Interdepartmental Plant Biology Major, Iowa State University, Ames, IA, 50011 1010, USA
    Plant Cell Rep 34:969-80. 2015
    ..Twelve transgenic maize lines were generated and analyzed for recombinant NP (rNP) expression. Transcript analysis showed the main accumulation of rNP in seed...
  92. pmc Facilitation of rice stripe virus accumulation in the insect vector by Himetobi P virus VP1
    Shuo Li
    College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
    Viruses 7:1492-504. 2015
    ..To characterize the virus-vector interactions, the SBPH cDNA library was screened with RSV ribonucleoprotein (RNP) as bait using a GAL4-based yeast two-hybrid system...
  93. pmc Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes
    Dirk Mühlbauer
    Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany
    J Virol 89:6009-21. 2015
    ..Furthermore, caspase 3/7 inhibition data obtained in this study suggest that active, Crm1-dependent IAV RNP export mechanisms are increasingly complemented by passive, caspase-induced export mechanisms at later stages of ..
  94. pmc Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation
    Peng Wang
    College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Biodynamic Optical Imaging Center BIOPIC, Peking University, Beijing 100871, China
    Nucleic Acids Res 43:7207-16. 2015
    H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation...
  95. pmc Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins
    Jyoti Batra
    School of Science, Monash University, Subang Jaya, Selangor, 47500, Malaysia
    Sci Rep 6:19063. 2016
    ..was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation...
  96. doi Controlling Interfacial Dynamics: Covalent Bonding versus Physical Adsorption in Polymer Nanocomposites
    Adam P Holt
    Department of Chemistry, Columbus State University, Columbus, Georgia 33232, United States
    ACS Nano 10:6843-52. 2016
    ..polymer chains either physically adsorbed (PNCs) or covalently bonded (PGNs) to identical silica nanoparticles (RNP = 12.5 nm) for three different molecular weight (MW) systems...
  97. pmc The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease
    Andria Pelava
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, U K
    Biochem Soc Trans 44:1086-90. 2016
    ..The ribosomal assembly intermediate 5S RNP (ribonucleoprotein particle), containing RPL5, RPL11 and the 5S rRNA, accumulates when ribosome biogenesis is ..
  98. pmc The Nucleolar Fibrillarin Protein Is Required for Helper Virus-Independent Long-Distance Trafficking of a Subviral Satellite RNA in Plants
    Chih Hao Chang
    Institute of Plant Biology, National Taiwan University, Taipei 11106, Taiwan
    Plant Cell 28:2586-2602. 2016
    ..The mobile satBaMV RNA appears to exist as ribonucleoprotein (RNP) complex composed of P20 and fibrillarin, whereas BaMV movement proteins, capsid protein, and BaMV RNA are ..
  99. ncbi 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins
    M Wittekind
    Macromolecular NMR Department, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Biochemistry 31:6254-65. 1992
    ..The beta alpha beta-beta alpha beta domain structure exhibits an antiparallel beta-sheet with the conserved RNP 1 and RNP 2 sequences [Dreyfuss et al. (1988) Trends Biochem. Sci...
  100. ncbi Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli
    J Wrzesinski
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110, USA
    Biochemistry 34:8904-13. 1995
    ..0 mol of psi/mol of RNA, depending on the preparation. Free RNA(1-678) was inactive, as was RNA(1-526) and the RNP particle made from it. 23S RNA and tRNAVal transcripts were also inactive...
  101. ncbi The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation
    J Wang
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340
    Genes Dev 8:2072-85. 1994
    ..Sxl contains two RNP-CS (RNA-binding) domains and is known to bind tra pre-mRNA near the alternative 3' splice site, thus blocking use ..

Research Grants65

  1. Structure and Function in Catalytic RNP Assembly
    Mark Foster; Fiscal Year: 2009
    ..and dynamic insights into how proteins modulate RNA structure and function in a catalytic ribonucleoprotein (RNP) complex...
  2. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Eric L Greidinger; Fiscal Year: 2011
    ..Immunity to snRNP autoantigens, including the Smith (Sm) and the U1-70RD polypeptide of the ribonucleoprotein (RNP) antigen, appears to have a central role in these diseases...
  3. Thomas Tuschl; Fiscal Year: 2016
    ..exRNAs and their associated proteins in serum, investigate mechanisms leading to circulating ribonucleoprotein (RNP) homeostasis, and identify protein factors contributing to cellular RNA release...
  4. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2013
    ..Pre- mRNA splicing occurs in a ribonucleoprotein (RNP) complex called the spliceosome, which is composed of a large number of proteins and multiple U small nuclear RNP ..
  5. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The assembly of ribonucleoprotein (RNP) complexes into microscopically visible granules occurs as part of the normal cellular regulation of RNA metabolism (processing bodies) and in response to ..
  6. EUGENE WEI MING YEO; Fiscal Year: 2016
    ..Finally, we will leverage our computational expertise to build predictive models using this genome-wide, multi-scale, mRNP code in the brain. ..
  7. Thomas Tuschl; Fiscal Year: 2016
    ..ligands, will by co-crystallized with their respective recombinant proteins placing emphasis on obtaining larger RNP structures...
  8. Methods for purification of individual nuclear pre-messenger RNA-protein complexe
    Donald C Rio; Fiscal Year: 2013
    ..constellation of RNA binding proteins that a given transcript acquires to form a distinct ribonucleoprotein (RNP) complex will control its RNA processing, RNA export and RNA stability...
  9. Mammalian Reovirus Post-transcriptional Gene Regulation
    CHARLES ROY MARTINEZ; Fiscal Year: 2010
    ..provide support for work which will focus on dissecting the structure-function relationships in ribonucleoprotein (RNP) complexes that mediate post-transcriptional gene regulation in viruses with double-strandedA (dsRNA) genomes...
  10. SARAH R TISDALE; Fiscal Year: 2014
    ..Our preliminary work identifies the assembly of the U7 snRNP - a RNP factor required for 3'-end processing of replication dependent histone mRNAs - as SMN-dependent in vivo...
  11. Protein-RNA Interactions in Biology and Disease
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ..of posttranscriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease...
  12. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..The assembly of HCV ribonucleoprotein complex (RNP) in response to TGF-21 will be examined by using two-step affinity purification of RNP complexes from HCV ..
  13. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    ..Our hypothesis is that SMN role in RNP assembly may extend to other cellular noncoding RNAs (ncRNAs), possibly with a motor neuron-specific expression ..
  14. The influenza A virus nucleoprotein: structure and function
    Yizhi Jane Tao; Fiscal Year: 2012
    ..eight segments of (-)RNA that are encapsidated in distinct double-helical structures called the ribonucleoprotein (RNP) complexes. The nucleoprotein (NP), the major protein component of RNPs, binds along genomic RNA at a 24nt interval...
  15. Michael D Stone; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The telomerase ribonucleoprotein (RNP) is required for maintaining telomeres, the specialized nucleoprotein structures that protect eukaryotic chromosome ends from aberrant processing and deleterious ..
  16. Translational regulation of cellular morphogenesis in early Drosophila embryos
    Paul M Macdonald; Fiscal Year: 2012
    ..regulation and that dFMRP and TRAL function during the MZT within dynamic cytoplasmic ribonucleoprotein (RNP) bodies (MZT bodies)...
  17. Kit for global RNP profiling
    RACHEL HAURWITZ; Fiscal Year: 2013
    ..To address this need, our Phase I goal is to develop a new and robust affinity separation technology for RNP complexes...
  18. Aleem Siddiqui; Fiscal Year: 2016
    ..HCV replicates its RNA genome within ribonucleoprotein complexes (RNP) consisting of viral and host cellular factors...
  19. Kathleen Collins; Fiscal Year: 2016
    ..TER) is expressed as a precursor that must be processed, folded, and assembled as a stable ribonucleoprotein (RNP) complex in order to accumulate to detectable level in vivo...
  20. A Gregory Matera; Fiscal Year: 2015
    ..Eukaryotic gene expression requires a constellation of small non-coding RNP particles that participate in multiple aspects of organismal function...
  21. Juli Feigon; Fiscal Year: 2016
    ..3'half contains the elements essential for localization, processing, TR accumulation, and binding the H/ACA RNP proteins...
  22. Zissimos Mourelatos; Fiscal Year: 2016
    ..Our understanding of gene expression regulation has changed radically with the discovery of ribonucleoprotein (RNP) complexes programmed with small RNAs...
  23. Elizabeth R Wright; Fiscal Year: 2014
    ..The M protein also orchestrates the incorporation of the viral glycoproteins and the ribonucleoprotein (RNP) into the evolving viral particles...
  24. U Thomas Meier; Fiscal Year: 2015
    ..by one of over 150 unique H/ACA RNAs, each of which associates with the same four core proteins to form an H/ACA RNP. The central core protein NAP57 (aka dyskerin) is mutated in the predominant X-linked form of the inherited bone ..
  25. Structure and Regulation of snoRNP Interaction with rRNA
    Hong Li; Fiscal Year: 2012
    ..Human telomerase is a specialized H/ACA RNP that exploits the H/ACA RNA domain for its localization and maturation...
  26. Tariq M Rana; Fiscal Year: 2014
    ..provided by applicant): The main goal of this work is to understand the role of small RNAs and ribonucleoprotein (RNP) complexes in creating innate immune response to viral infections...
  27. Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    TARIQ RANA; Fiscal Year: 2009
    ..P-TEFb is inactivated by sequestration into a large ribonucleoprotein (RNP) complex containing the small nuclear RNA, 7SK, and the Hexim1 protein...
  28. Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    Tariq M Rana; Fiscal Year: 2013
    ..P-TEFb is inactivated by sequestration into a large ribonucleoprotein (RNP) complex containing the small nuclear RNA, 7SK, and the Hexim1 protein...
  29. Jens Lykke-Andersen; Fiscal Year: 2015
    ..Third, it will be tested whether ATPase activity of MOV10, a homolog of Upf1, is required for RNP remodeling during mRNA degradation activated by the RNA induced silencing complex (RISC) in complex with microRNAs...
  30. Cell growth control by cell and organelle size-dependent ribosome biogenesis
    Clifford P Brangwynne; Fiscal Year: 2012
    ..We recently introduced the novel concept that non-membrane bound ribonucleoprotein (RNP) bodies, including the ribosome-producing nucleolus, are dynamic liquid phase micro-reactors for rapid RNA ..
  31. Hepatitis delta virus RNA-protein complexes
    John L Casey; Fiscal Year: 2010
    ..The long-term objectives are to determine the structure of the HDV RNP and its specific roles in virus replication and packaging...
  32. Mechanisms directing oncoprotein and cytokine mRNA decay
    Gerald M Wilson; Fiscal Year: 2013
    ..to define the roles of specific molecular determinants in the formation of stable, functional ribonucleoprotein (RNP) complexes on AREs...
  33. Elizabeth R Gavis; Fiscal Year: 2016
    ..subcellular domains is a complex process involving the assembly and trafficking of large ribonucleoprotein (RNP) complexes...
  34. Lin He; Fiscal Year: 2014
    ..More importantly, our technology can be easily adapted to study cancer related RNP complexes containing other ncRNA species...
  35. Nuclear bodies and ribonucleoprotein biogenesis
    Michael D Hebert; Fiscal Year: 2012
    ..body organization between different cell types is a manifestation of the most efficient nuclear configuration for RNP biogenesis...
  36. Paul K Herman; Fiscal Year: 2016
    ..This proposal extends this analysis and examines a particular ribonucleoprotein (RNP) complex that forms in the cytoplasm of resting cells, known as a Processing-body, or P-body...
  37. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..immune response, and understand activity relationships of the surface glycoproteins (HA, NA) and ribonucleoprotein (RNP) complex, including the polymerase (PA, PB1, PB2), that underlie the pathogenicity and transmissibility of pandemic ..
  38. Francis C Luca; Fiscal Year: 2016
    ..Specifically, we have shown that Cbk1 phosphorylates the ribonucleoprotein (RNP) Ssd1 and promotes the polar localization of a subset of Ssd1-mRNA complexes, suggesting that NDR kinases promote ..
  39. Sean Pj Whelan; Fiscal Year: 2014
    ..imaging approaches to probe the relationships between hemifusion, fusion pore formation and transfer of the RNP across a lipid bilayer in vitro...
  40. Westley H Reeves; Fiscal Year: 2015
    ..In mice with lupus caused by i.p. injection of tetramethylpentadecane (TMPD, pristane), anti-Sm/RNP and anti-DNA autoantibodies are induced and immune complex-mediated glomerulonephritis develops...
  41. Molecular Mechanisms of Rhabdovirus Entry
    Sean Whelan; Fiscal Year: 2009
    ..imaging approaches to probe the relationships between hemifusion, fusion pore formation and transfer of the RNP across a lipid bilayer in vitro...
  42. Elizabeth H Blackburn; Fiscal Year: 2016
    ..involve not only the active reverse transcriptase-competent form of the full telomerase ribonucleoprotein (RNP), but also the abundantly expressed, yet poorly characterized, reverse transcriptase-incompetent b- splice variant ..
  43. VIVIAN G BUDNIK; Fiscal Year: 2016
    ..These studies are likely to be paradigm-shifting for our understanding of how and where large RNP transport granules are formed, which is elemental to the understanding of how the precise polarized assembly of ..
  44. RACHEL ANNE MALONEY; Fiscal Year: 2015
    ..DFz2C localizes to prominent foci at the periphery of muscle nuclei, which associate with large ribonucleoprotein (RNP) granules...
  45. Assembly of the AI5-beta Group I Intron RNP
    Edward Turk; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): This proposal will elucidate the mechanisms of ribonucleoprotein (RNP) biogenesis...
  46. REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEAST
    RONALD BUTOW; Fiscal Year: 2007
    ..splicing, and in[unreadable] particular, to resolve excised group I introns from ribonucleoprotein[unreadable] (RNP) splicing complexes...
  47. Assembly and export of HIV messenger ribonucleoproteins
    JOHN ROBERT HOGG; Fiscal Year: 2010
    ..the precise step of mRNA maturation affected, allowing a hypothesis-driven investigtion of HIV mRNA processing and RNP assembly. The specific properties of the 3'LTR leading to N86-hnRNPU-sensitivity are unknown...
  48. RNase P as a Model for Ribonucleoprotein Assembly
    STACY CHAMBERLIN; Fiscal Year: 2005
    Ribonucleoprotein (RNP) complexes are integral to cellular function and control of RNP assembly is an important cellular regulatory mechanism and an attractive therapeutic target...
  49. FUNCTION OF THE FIBRILLARIN METHYLATED DOMAIN IN VIVO
    Mark Christensen; Fiscal Year: 1993
    Long term objectives include establishing the biological significance of the diverse nuclear ribonucleoprotein (RNP) particles which exist in eukaryotic cells and characterizing the functional/evolutionary relationships among certain ..
  50. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..to Sm and nRNP are apparently of high titer in that they precipitate in double immunodiffusion assays and bind RNP antigens in solution phase and by immunoblots. In essence, by immunizing rabbits with peptides, Dr. James and Dr...
  51. Jack D Keene; Fiscal Year: 2015
    ..While protein components of RNP granules have been studied in mammalian cells, quantitative RNA population dynamics have not been analyzed for lack ..
  52. Bert L Semler; Fiscal Year: 2016
    ..The experiments proposed in the third aim will examine the nature of RNP complexes formed with the 5'NCRs of these two cellular mRNAs to define the determinants of IRES functions for ..
  53. DAVID LEONARD BENTLEY; Fiscal Year: 2014
    ..3. To determine how assembly of export competent RNP's is coordinated with processing of the mRNA by cleavage-polyadenylation...
  54. NUCLEAR PROTEINS AND AUTOIMMUNITY
    SALLIE HOCH; Fiscal Year: 1992
    ..Two such antigens have been designated Sm and RNP. Together these antigens are represented by at least 10 polypeptides, all of which are part of larger particles ..
  55. NUCLEAR ACIDIC PROTEIN ANTIGENS IN RHEUMATIC DISEASES
    GORDON SHARP; Fiscal Year: 1990
    ..Patient autoimmune antibodies directed against distinct antigens (RNP, Sm and Me) of the ubiquitous U1 small nuclear ribonucleoprotein particle (U1 snRNP) are strongly associated with ..
  56. Laurie K Read; Fiscal Year: 2014
    ..for gene regulatory functions including trans splicing, translation initiation, and the formation of cytoplasmic RNP granules implicated in RNA turnover and translational control...
  57. Protein Arginine Methylation in Trypanosomes
    LAURIE READ; Fiscal Year: 2009
    ..for gene regulatory functions including trans splicing, translation initiation, and the formation of cytoplasmic RNP granules implicated in RNA turnover and translational control...
  58. CHARACTERIZATION OF RHEUMATOID ANTIGENS IN CYANOBACTERIA
    SHIRLEY KOVACS; Fiscal Year: 1991
    ..connective tissue disease (MCTD) patients produce autoantibodies directed against distinct antigenic sites (Sm and RNP respectively) on the ubiquitous U1 small nuclear ribonucleoprotein particle (U1snRNP or U1RNP) of eucaryotic cells...
  59. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
    ..This is the first step toward deciphering the 'RNP code'for PMR1-mRNA decay...
  60. Expression control in Drosophila splicing assembly factor RNP-4F
    JACK VAUGHN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Drosophila RNP-4F is an ortholog to human p110, which functions with the pre-mRNA processing (PRP) protein class as a recycling factor to carry U4- and U6-snRNPs to the assembling spliceosome...
  61. Dysregulation of VEGF RNA Stability in Amyotrophic Lateral Sclerosis
    Liang Lu; Fiscal Year: 2012
    ..Second, we will analyze the interaction between mutant SOD1 proteins, HuR and the RNP complex associated with the VEGF 3'UTR to determine why mutant SOD1 negatively affects VEGF RNA processing...
  62. Kinetoplastid SL RNA biogenesis
    David A Campbell; Fiscal Year: 2013
    ..Using the SmD3 protein, the SL RNA RNP complex and associated splicing machinery, both catalytic and core, has been captured...
  63. TELOMERASE RNP STRUCTURE/FUNCTION
    DOROTHY SHIPPEN; Fiscal Year: 2001
    ..The primary mechanism for synthesizing teleomeres is telomerase, an unusual ribonucleoprotein (RNP) with reverse transcriptase activity...
  64. Crystallizing Hepatitis B Virus Reverse Transcriptase
    Hwai Chen Guo; Fiscal Year: 2006
    ..A critical early step in HBV replication is the assembly of a specific ribonucleoprotein (RNP) complex between the viral reverse transcriptase (RT) and a specific RNA signal called Epsilon, located at the 5&..
  65. IMMUNE MECHANISMS IN PRISTANE INDUCED LUPUS NEPHRITIS
    Westley Reeves; Fiscal Year: 2003
    ..This syndrome is characterized by disease-specific autoantibody production (anti-Sm, RNP, Su, ribosomal P, double stranded DNA), hypergammaglobulinemia, and severe immune complex-mediated ..