RNASEL

Summary

Gene Symbol: RNASEL
Description: ribonuclease L
Alias: PRCA1, RNS4, 2-5A-dependent ribonuclease, 2',5'-oligoisoadenylate synthetase-dependent, 2-5A-dependent RNase, RNase L, interferon-induced 2-5A-dependent RNase, ribonuclease 4
Species: human

Top Publications

  1. ncbi Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action
    A Zhou
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195
    Cell 72:753-65. 1993
  2. ncbi Implications for RNase L in prostate cancer biology
    Robert H Silverman
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biochemistry 42:1805-12. 2003
  3. pmc A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L
    Krishnamurthy Malathi
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 102:14533-8. 2005
  4. ncbi A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region
    J D Carpten
    Cancer Genetics Branch, Bethesda, Maryland 20892, USA
    Genomics 64:1-14. 2000
  5. ncbi Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway
    C Bisbal
    Institut de Génétique Moléculaire UMR 9942, CNRS Université de Montpellier I et II, France
    J Biol Chem 270:13308-17. 1995
  6. ncbi Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
    J R Smith
    National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA
    Science 274:1371-4. 1996
  7. ncbi The 2-5A system in viral infection and apoptosis
    J Castelli
    Biochemistry Section, NINDS, NIH, Bethesda, MD 20892, USA
    Biomed Pharmacother 52:386-90. 1998
  8. pmc Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L
    B Dong
    Department of Cancer Biology, NN10, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nucleic Acids Res 27:439-45. 1999
  9. pmc Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p
    B Dong
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA
    RNA 7:361-73. 2001
  10. ncbi Germline mutations in the ribonuclease L gene in families showing linkage with HPC1
    J Carpten
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Genet 30:181-4. 2002

Research Grants

  1. Susan R Weiss; Fiscal Year: 2016
  2. Ila R Singh; Fiscal Year: 2014
  3. David J Barton; Fiscal Year: 2016
  4. Cigarette Smoke, RIG-like Helicases and Alveolar Remodeling
    Jack A Elias; Fiscal Year: 2012
  5. Infection with Bordetella pertussis exacerbates Influenza infection
    VICTOR ISAAC AYALA; Fiscal Year: 2010
  6. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2009
  7. ANTIVIRAL ACTIONS OF INTERFERONS
    Ganes Sen; Fiscal Year: 1992
  8. Role of antiviral defense in autoimmune Type 1 Diabetes
    Vagn Bonnevie Nielsen; Fiscal Year: 2005
  9. Alphavirus Minus Strand RNA Synthesis and RNase L
    DOROTHEA SAWICKI; Fiscal Year: 2009
  10. 2-5A Antisense for Degradation of SARS Coronavirus RNA
    Hagen Cramer; Fiscal Year: 2004

Detail Information

Publications168 found, 100 shown here

  1. ncbi Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action
    A Zhou
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195
    Cell 72:753-65. 1993
    ..coli. Interestingly, a duplicated phosphate-binding loop motif was determined by deletion analysis and site-directed mutagenesis to function in the binding of 2-5A...
  2. ncbi Implications for RNase L in prostate cancer biology
    Robert H Silverman
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biochemistry 42:1805-12. 2003
    ..S., Finland, and Israel, support the recent identification of the RNase L gene, RNASEL, as a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) allele...
  3. pmc A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L
    Krishnamurthy Malathi
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 102:14533-8. 2005
    ..by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RNase L. Although RNase L is required for a complete IFN antiviral response and mutations in the RNase L gene (RNASEL or ..
  4. ncbi A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region
    J D Carpten
    Cancer Genetics Branch, Bethesda, Maryland 20892, USA
    Genomics 64:1-14. 2000
    ..An additional 11 known genes and ESTs have been placed within the larger 1q24-q31 interval. These transcription units represent candidate genes for multiple hereditary diseases, including HPC1...
  5. ncbi Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway
    C Bisbal
    Institut de Génétique Moléculaire UMR 9942, CNRS Université de Montpellier I et II, France
    J Biol Chem 270:13308-17. 1995
    The 2-5A/RNase L system is considered as a central pathway of interferon (IFN) action and could possibly play a more general physiological role as for instance in the regulation of RNA stability in mammalian cells...
  6. ncbi Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
    J R Smith
    National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA
    Science 274:1371-4. 1996
    ..The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1...
  7. ncbi The 2-5A system in viral infection and apoptosis
    J Castelli
    Biochemistry Section, NINDS, NIH, Bethesda, MD 20892, USA
    Biomed Pharmacother 52:386-90. 1998
    ..Interferon treatment of cells leads to an increase in basal, but latent, levels of 2-5A-dependent RNase (RNase L) and the family of 2'-5' oligoadenylate synthetases (OAS)...
  8. pmc Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L
    B Dong
    Department of Cancer Biology, NN10, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nucleic Acids Res 27:439-45. 1999
    b>RNase L is the 2',5'-oligoadenylate (2-5A)-dependent endoribonuclease that functions in interferon action and apoptosis. One of the intriguing, albeit unexplained, features of RNase L is its significant homology to protein kinases...
  9. pmc Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p
    B Dong
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio 44195, USA
    RNA 7:361-73. 2001
    b>RNase L and Ire1p are members of a superfamily of regulated endoribonucleases that play essential roles in mediating diverse types of cellular stress responses...
  10. ncbi Germline mutations in the ribonuclease L gene in families showing linkage with HPC1
    J Carpten
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Genet 30:181-4. 2002
    ..Here we report that germline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) segregate in prostate cancer families that show linkage to the HPC1 (hereditary prostate cancer 1) ..
  11. pmc Analysis of the RNASEL gene in familial and sporadic prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 71:116-23. 2002
    The RNASEL gene on chromosome 1q25 was recently identified as a candidate gene for hereditary prostate cancer (PC)...
  12. pmc A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews
    Hanna Rennert
    Genetic Institute, Tel Aviv Sourasky Medical Center, Israel
    Am J Hum Genet 71:981-4. 2002
    HPC1/RNASEL was recently identified as a candidate gene for hereditary prostate cancer. We identified a novel founder frameshift mutation in RNASEL, 471delAAAG, in Ashkenazi Jews...
  13. ncbi RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
    Graham Casey
    Department of Cancer Biology, ND50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Genet 32:581-3. 2002
    b>RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene...
  14. ncbi Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer
    Akin Sevinc
    Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
    Anticancer Res 24:2547-9. 2004
    ..Considering the function of RNase L and the pleiotropic effects of mutations associated with cancer, we sought to investigate whether the RNASEL ..
  15. pmc Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene
    C Maier
    Abteilung Humangenetik, Universitat Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Br J Cancer 92:1159-64. 2005
    ..RNASEL, encoding the 2',5'-oligoadenylate-dependant RNase L, seems to have rare mutations in different ethnicities, such as M1I in Afro-Americans, E265X in men of European ..
  16. ncbi Association of susceptibility alleles in ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer severity in European American and African American men
    Hanna Rennert
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Health System, 7 Gates West, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 14:949-57. 2005
    Reported associations of ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer have been inconsistent and understudied in African Americans...
  17. ncbi A newly discovered function for RNase L in regulating translation termination
    Florence Le Roy
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Struct Mol Biol 12:505-12. 2005
    The antiviral and antiproliferative effects of interferons are mediated in part by the 2'-5' oligoadenylate-RNase L RNA decay pathway. RNase L is an endoribonuclease that requires 2'-5' oligoadenylates to cleave single-stranded RNA...
  18. ncbi RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
    The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested...
  19. ncbi Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways
    David J Bettoun
    Department of Molecular Endocrinology, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
    J Biol Chem 280:38898-901. 2005
    ..pull-down and co-immunoprecipitation experiments reveal that the androgen receptor and the interferon-activated RNase L interact with each other in a ligand-dependent manner...
  20. ncbi RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis
    Huihua Li
    Biostatistics Unit, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 129610, Singapore
    Clin Cancer Res 12:5713-9. 2006
    Studies revealing conflicting results on the role of RNASEL polymorphisms Glu265X, Arg462Gln, and Asp541Glu on prostate cancer risk led us to perform a meta-analysis to investigate the association of these polymorphisms and prostate ..
  21. ncbi Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells
    Mitali Pandey
    Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    RNA Biol 1:21-7. 2004
    ..is primarily brought about by the IFN-inducible 2',5'-oligoadenylate (2-5A)-cofactor dependent ribonuclease L (RNase L). RNase L also functions as a tumor suppressor gene in case of prostate cancer due to its role in apoptosis...
  22. ncbi The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1
    Stefan Kruger
    Department of Surgical Research, Dresden University of Technology, D 01307 Dresden, Germany
    Cancer Lett 252:55-64. 2007
    p53 and the prostate-cancer-susceptibility gene RNASEL are tumour suppressor genes involved in apoptosis...
  23. ncbi Post-transcriptional regulation of RNase-L expression is mediated by the 3'-untranslated region of its mRNA
    Xiao Ling Li
    University of Maryland, Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Cancer Center, Graduate Program in Molecular Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 282:7950-60. 2007
    ..Little is known about the control of RNASEL expression; therefore, we examined the potential regulatory role of a conserved 3'-untranslated region (3'-UTR) in ..
  24. pmc Diverse functions of RNase L and implications in pathology
    Catherine Bisbal
    IGH UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier, France
    Biochimie 89:789-98. 2007
    The endoribonuclease L (RNase L) is the effector of the 2-5A system, a major enzymatic pathway involved in the molecular mechanism of interferons (IFNs). RNase L is a very unusual nuclease with a complex mechanism of regulation...
  25. ncbi RNASEL Arg462Gln polymorphism and prostate cancer in PLCO
    Sarah E Daugherty
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prostate 67:849-54. 2007
    The Gln allele of the Arg462Gln polymorphism in RNASEL results in a threefold decrease in enzymatic activity, a reported deficiency in apoptotic response, and has been associated with prostate cancer in some high-risk family studies...
  26. ncbi Association of RNASEL variants with prostate cancer risk in Hispanic Caucasians and African Americans
    Stacie J Shook
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Clin Cancer Res 13:5959-64. 2007
    The RNASEL gene at 1q25 has been identified as a hereditary prostate cancer susceptibility gene, but to date, no study has investigated the role of RNASEL variants in Hispanic Caucasian men with prostate cancer.
  27. pmc Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer
    Bo Eskerod Madsen
    Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark
    PLoS ONE 3:e2492. 2008
    THE BACKGROUND: Ribonuclease L (RNASEL), encoding the 2'-5'-oligoadenylate (2-5A)-dependent RNase L, is a key enzyme in the interferon induced antiviral and anti-proliferate pathway...
  28. pmc Endoribonuclease L (RNase L) regulates the myogenic and adipogenic potential of myogenic cells
    Tamim Salehzada
    INSERM ESPRI 25 Muscle et Pathologies, EA4202 Université de Montpellier I, CHU Arnaud de Villeneuve, Montpellier, France
    PLoS ONE 4:e7563. 2009
    ..For instance, we previously showed that the endoribonuclease L (RNase L) and its inhibitor (RLI) regulates MyoD mRNA stability and consequently muscle differentiation...
  29. doi Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line
    Akira Sato
    Department of Molecular Drug Informatics, Faculty of Pharmaceutical Sciences, Tsushima, Okayama, Okayama University, Japan
    FEBS J 277:4464-73. 2010
    Mammalian intracellular ribonuclease L (RNase L) is a latent endoribonuclease that functions against viral infections as an apoptosis-inducing protein, and its activity requires intracellular 5'-end-triphosphorylated-2',5' ..
  30. doi RNASEL -1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case-control studies
    Li Feng Zhang
    Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People s Republic of China
    Mol Biol Rep 38:5099-105. 2011
    Polymorphisms in the endoribonuclease L (RNASEL) gene have been hypothesized to increase the incidence of cancer. The common sequence variation in RNASEL, -1385G/A (rs486907) has been involved in several types of cancer risk...
  31. doi RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis
    Bingbing Wei
    Department of Urology, Affiliated Wuxi People s Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China
    Mol Biol Rep 39:2347-53. 2012
    Epidemiological studies have evaluated the association between RNASEL Asp541Glu and Arg462Gln polymorphisms and prostate cancer (PCa) risk. However, the results remain inconclusive...
  32. pmc RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways
    Mohammad Adnan Siddiqui
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    J Biol Chem 287:43651-64. 2012
    ..Several proteins associated with autophagy regulate host responses to viral infections. Ribonuclease L (RNase L) is activated during viral infections and cleaves cellular and viral single-stranded RNAs, including rRNAs in ..
  33. pmc Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemia
    Teresa Y Lee
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Interferon Cytokine Res 33:34-42. 2013
    ..Using a luciferase reporter, we showed that miR-29 acts via 4 target sites within the RNASEL 3' UTR. Mutation of all sites is required for abrogation of miR-29 repression...
  34. pmc Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
    Yuchen Han
    Department of Molecular Biology, Princeton University, 216 Schultz Laboratory, Princeton, NJ 08540, USA
    Science 343:1244-8. 2014
    ..IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L. We report 2.8 and 2...
  35. pmc Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function
    Tiha M Long
    Graduate Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 82:2802-14. 2014
    ..The endoribonuclease RNase L is a key mediator of IFN induction and action that promotes TJ protein expression and IEC barrier integrity...
  36. pmc A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon
    B A Hassel
    Department of Cancer Biology, Cleveland Clinic Foundation, OH 44195
    EMBO J 12:3297-304. 1993
    ..The truncated RNase is a dominant negative mutant that binds 2-5A and that may interfere with normal protein-protein interactions through nine ankyrin-like repeats...
  37. pmc Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer
    Annika Rökman
    Laboratory of Cancer Genetics, Institute of Medical Technology, Temepere University, and Tempere University Hospital, Tempere, Finland
    Am J Hum Genet 70:1299-304. 2002
    The RNASEL gene (2',5'-oligoisoadenylate-synthetase dependent) encodes a ribonuclease that mediates the antiviral and apoptotic activities of interferons...
  38. ncbi Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Clin Cancer Res 10:7150-6. 2004
    The RNASEL gene has been proposed as a candidate gene for the HPC1 locus through a positional cloning and candidate gene approach...
  39. pmc Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population
    H Nakazato
    Department of Urology, Gunma University School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma, 3718511, Japan
    Br J Cancer 89:691-6. 2003
    The RNASEL gene on chromosome 1q25 has been identified as a prostate cancer susceptibility gene...
  40. ncbi A single amino acid substitution changes ribonuclease 4 from a uridine-specific to a cytidine-specific enzyme
    J Hofsteenge
    Friedrich Miescher Institut, Basel, Switzerland
    Biochemistry 37:9250-7. 1998
    The structural features underlying the strong uridine specificity of ribonuclease 4 (RNase 4) are largely unknown...
  41. ncbi Expression of interferon-inducible recombinant human RNase L causes RNA degradation and inhibition of cell growth in Escherichia coli
    Mitali Pandey
    Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Biochem Biophys Res Commun 317:586-97. 2004
    Interferon-inducible ribonuclease L (RNase L) is a unique ankyrin-repeat containing endoribonuclease activated by 2',5'-oligoadenylate (2-5A) cofactor leading to RNA degradation and apoptosis during antiviral response in mammalian cells...
  42. doi Modulation of the blood-brain barrier permeability by plasma glycoprotein orosomucoid
    Wei Yuan
    Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA
    Microvasc Res 80:148-57. 2010
    ..8-fold, compared to their control values. Our results indicate that orosomucoid can modulate the permeability of the BBB to charged molecules by adding negative charge to the matrix components of the BBB...
  43. ncbi Perspective: prostate cancer susceptibility genes
    Jacques Simard
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec City, G1V 4G2, Canada
    Endocrinology 143:2029-40. 2002
    ..gene analysis were used to map several genes, including the 2'-5'-oligoadenylate-dependent ribonuclease L (RNASEL) gene, to the critical region of HPC1...
  44. doi Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome
    U Mihm
    Medizinische Klinik I, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    J Viral Hepat 17:217-21. 2010
    ..Interferon-alpha indirectly induces cleavage of viral RNA by RNase L at UU/UA dinucleotides...
  45. ncbi Production of anti-virus, viroid plants by genetic manipulations
    Isao Ishida
    Pharmaceutical Division, Kirin Brewery Co Ltd, Tokyo 104 8288, Japan
    Pest Manag Sci 58:1132-6. 2002
    ..I protein and animal cell derived interferon-induced 2',5'-oligoadenylate synthetase (2-5 Aase)/ribonuclease L (RNase L) system into various plants may make plants resistant to various pathogenic viruses and viroids...
  46. pmc Cleavage of Treponema denticola PrcA polypeptide to yield protease complex-associated proteins Prca1 and Prca2 is dependent on PrtP
    Si Young Lee
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Bacteriol 184:3864-70. 2002
    ..PrcA constructs confirmed that PrcA is cleaved to yield the two smaller proteins of the CTLP complex, designated PrcA1 and PrcA2...
  47. pmc Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex
    Valentina Godovikova
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Bacteriol 192:3337-44. 2010
    ..denticola surface protease complex, consisting of PrtP protease (dentilisin) and two auxiliary polypeptides (PrcA1 and PrcA2), is believed to contribute to periodontal disease by degrading extracellular matrix components and ..
  48. pmc Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients
    Oliver Hohn
    Robert Koch Institute, Centre for Biological Safety 4, Nordufer 20, 13353 Berlin, Germany
    Retrovirology 6:92. 2009
    ..a prevalence of 40% in prostate tumor samples from American patients carrying a homozygous R462Q mutation in the RNaseL gene...
  49. ncbi X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi
    Annette Karcher
    Center for Integrated Protein Science and Center for Advanced Photonics at the Gene Center, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    J Biol Chem 283:7962-71. 2008
    ..The structure substantially expands the functional architecture of ABC enzymes and raises the possibility that ABCE1 is a chemomechanical engine linked to a redox process...
  50. ncbi Evidence for age-dependent impairment of antiviral 2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of rat
    K Pfeifer
    Institut fur Physiologische Chemie, Universitat, Mainz, Germany
    Mech Ageing Dev 67:101-14. 1993
    ..The effects of 2-5A are mediated by a 2-5A-dependent ribonuclease (RNase L) which cleaves viral RNA...
  51. pmc Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006
    Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer...
  52. doi Antagonizing activity of vaccinia virus E3L against human interferons in Huh7 cells
    Janilyn Arsenio
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba Canada R3E 0W3
    Virology 377:124-32. 2008
    ..for its capacity to evade cellular innate antiviral immunity related to interferon (IFN), for example PKR and RNaseL mediated antiviral activities...
  53. pmc Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L
    Nobutada Tanaka
    School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawa ku, Tokyo, Japan
    EMBO J 23:3929-38. 2004
    An interferon-induced endoribonuclease, ribonuclease L (RNase L), is implicated in both the molecular mechanism of action of interferon and the fundamental control of RNA stability in mammalian cells...
  54. doi Trans-fatty acids and cancer: the evidence reviewed
    Abby K Thompson
    Department of Food Biosciences, University of Reading, Reading RG6 6AP, UK
    Nutr Res Rev 21:174-88. 2008
    ..but a recent large case-control study has shown a strong interaction between risk and trans-FA intake for the RNASEL QQ/RQ genotype that is present in about 35 % of the population...
  55. ncbi Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41
    Daniel E Holloway
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 43:1230-41. 2004
    ..to penetrate the B(1) site, raising the possibility that it participates in substrate binding as occurs in ribonuclease 4. (ii) The structure of T80A-Ang supports the view that Thr80 plays little role in maintaining the obstructive ..
  56. ncbi Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, Azienda Ospedaliera Umberto I, 60020 Torrette, Ancona, Italy
    Virchows Arch 444:503-8. 2004
    ..development of PCa, mutations in a growing number of candidate hereditary prostate cancer loci and genes, such as RNASEL and MSR1, have been detected, suggesting that defects in critical pathways involving DNA damage response, ..
  57. pmc Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes
    Jonathan J Rios
    Department of Animal Science, Texas A and M University, 2471 TAMU, College Station, Texas 77843, USA
    BMC Genomics 8:313. 2007
    The mammalian OAS/RNASEL pathway plays an important role in antiviral host defense...
  58. ncbi [Structural and functional studies on proteins as potential drug discovery targets]
    Nobutada Tanaka
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Yakugaku Zasshi 127:1673-83. 2007
    ....
  59. ncbi DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland
    Cezary Cybulski
    International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    Urol Int 79:44-9. 2007
    We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland.
  60. ncbi cDNA cloning and expression analysis of the murine ribonuclease L inhibitor
    A Benoit De Coignac
    IGMM CNRS UMR 5535, 1919 Route de Mende, 34293, Montpellier Cedex 5, France
    Gene 209:149-56. 1998
    The 2-5A/RNase L system is one of the pathways induced by interferon (IFN). It plays a major role in the antiviral and antiproliferative activities of IFNs...
  61. ncbi Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Mol Cancer Res 4:575-89. 2006
    ..Expression of the proapoptotic LITAF, IFNGR, EREG, TNFSF/TNFRSF10 and TNFRSF12, FAS, and RNASEL is primarily up-regulated/induced in cells destined to undergo apoptosis...
  62. ncbi Organization of the interferon-inducible 2',5'-oligoadenylate-dependent ribonuclease L (RNase L) gene of mouse
    Mitali Pandey
    Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Mol Biol Rep 34:97-104. 2007
    Interferons (IFNs) induce a 2',5'-oligoadenylate (2-5A)-dependent ribonuclease L (RNase L) following virus-infection of mammalian cells. RNase L degrades both viral and cellular RNAs and restricts virus-proliferation...
  63. ncbi Genetic variability in inflammation pathways and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University, Winston Salem, NC 27157, USA
    Urol Oncol 25:250-9. 2007
    ..This includes 2 genes identified through family studies, ribonuclease L (RNASEL) and macrophage scavenger receptor 1 (MSR1), as well as a number of genes suggested by case-control studies, such ..
  64. doi Inflammation, infection, and prostate cancer
    Eric A Klein
    Glickman Urologic and Kidney Institute, Cleveland, Ohio, USA
    Curr Opin Urol 18:315-9. 2008
    ..Recent evidence suggesting that inflammation and infection play a role in the etiology of prostate cancer, and the discovery of a novel virus in men with a genetic susceptibility to prostate cancer is reviewed...
  65. pmc Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes
    Joan P Breyer
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0275, USA
    Cancer Epidemiol Biomarkers Prev 18:2137-44. 2009
    ..We also find evidence to support reported associations at candidate genes RNASEL, EZH2, and NKX3-1 (P = 0.031 to P = 0.0085)...
  66. doi The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome
    Robert H Silverman
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nat Rev Urol 7:392-402. 2010
    ..retrovirus first identified in prostate cancer tissues from men with a deficiency in the innate immunity gene RNASEL. At present, studies have detected XMRV at widely different rates in prostate cancer cases (0-27%) and in patients ..
  67. ncbi Molecular cloning and expression of human ribonuclease 4 cDNA
    M Seno
    Department of Bioengineering Science, Faculty of Engineering, Okayama University, Japan
    Biochim Biophys Acta 1261:424-6. 1995
    A cDNA coding for human ribonuclease 4 was isolated from a pancreas cDNA library and sequenced. This cDNA (996 bp) includes an entire open reading frame encoding mature protein (119 aa) following signal peptide (28 aa)...
  68. ncbi The role of inflammation in the pathogenesis of prostate cancer
    William G Nelson
    Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 172:S6-11; discussion S11-2. 2004
    ..A new hypothesis for the etiology of prostate cancer is that chronic or recurrent prostate inflammation may initiate and promote prostate cancer development...
  69. pmc Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L
    Rebecca J Duerst
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Virology 360:322-8. 2007
    b>RNase L helps mediate the antiviral state induced by type I interferons (IFNalphabeta)...
  70. pmc Interferon-inducible antiviral effectors
    Anthony J Sadler
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nat Rev Immunol 8:559-68. 2008
    ..Ongoing research continues to expose additional activities for these effector proteins and has revealed unanticipated functions of the antiviral response...
  71. ncbi Contribution of Tyr712 and Phe716 to the activity of human RNase L
    Masayuki Nakanishi
    Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Eur J Biochem 271:2737-44. 2004
    Ribonuclease L (RNase L) is a key enzyme in the 2-5A host defense system, and its activity is strictly regulated by an unusual 2',5'-linked oligoadenylate (2-5A)...
  72. doi CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling
    Raquel Pluvinet
    Medical and Molecular Genetics Center, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
    Blood 112:3624-37. 2008
    ..Conversely, CD40-mediated up-regulation of the viral immune surveillance system, notably TLR3, IFIH1, RIG-I, and RNASEL, establishes a reverse link from adaptive to innate immunity in ECs...
  73. pmc Tetherin and its viral antagonists
    Björn D Kuhl
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Neuroimmune Pharmacol 6:188-201. 2011
    ..In addition to a number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1...
  74. pmc Prognostic role of genetic biomarkers in clinical progression of prostate cancer
    María Jesús Alvarez-Cubero
    1 Laboratory of Genetic Identification, Faculty of Medicine, Legal Medicine and Toxicology Department, University of Granada, Granada, Spain 2 GENYO Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research, Granada, Spain
    Exp Mol Med 47:e176. 2015
    The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk ..
  75. pmc Age-related methylation profiles of equine blood leukocytes in the RNASEL locus
    T Zabek
    National Research Institute of Animal Production, Krakowska 1, 32 083, Balice, Poland
    J Appl Genet 57:383-8. 2016
    Methylation profiles across three CpG islands of the RNASEL gene were determined in blood leukocyte samples of Anglo-Arabian and Hucul horses...
  76. pmc A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L
    Hannah L Townsend
    Department of Microbiology, University of Colorado Denver, School of Medicine, Aurora, Colorado 80045, USA
    RNA 14:1026-36. 2008
    Ribonuclease L (RNase L) is a latent endoribonuclease in an evolutionarily ancient interferon-regulated dsRNA-activated antiviral pathway...
  77. pmc XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
    ..We found XMRV infection to be independent of a common polymorphism in the RNASEL gene, unlike results previously reported...
  78. doi Identification of cellular genes induced in human cells after activation of the OAS/RNaseL pathway by vaccinia virus recombinants expressing these antiviral enzymes
    Elena Domingo-Gil
    Department of Cellular and Molecular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, Madrid, Spain
    J Interferon Cytokine Res 30:171-88. 2010
    ..The enzyme OAS is activated by dsRNA to produce 5'-phosphorylated, 2-5-linked oligoadenylates (2-5A) that activate RNaseL which, in turn, triggers RNA breakdown, leading to multiple biological functions...
  79. pmc OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses
    Jonathan J Rios
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10537. 2010
    ..Previous studies in mice identified the Oas1b gene, a member of the OAS/RNASEL innate immune system, as a determining factor for resistance to West Nile virus (WNV) infection...
  80. pmc Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Prostate 70:1716-27. 2010
    Prostate cancer is a genetically complex disease with locus and disease heterogeneity. The RNASEL gene and HPCX locus have been implicated in hereditary prostate cancer; however, their contributions to sporadic forms of this malignancy ..
  81. ncbi [Epidemiology and risk factors of the prostate cancer]
    Dominika Stasiewicz
    St John s Cancer Center, Lublin, Poland
    Pol Merkur Lekarski 33:163-7. 2012
    ..established risk factors are advancing age, ethnicity and genetics, including changing in expression of ELAC2, RNASEL, MSR1 and HOXB13 genes as well as low number of CAG repeats in the androgen receptor gene...
  82. pmc Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs
    Daphne A Cooper
    Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA, Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA and Program in Molecular Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Nucleic Acids Res 42:5202-16. 2014
    Ribonuclease L (RNase L) is a metal-ion-independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan...
  83. pmc The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation
    Mikkel Søes Ibsen
    Centre for Structural Biology, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
    J Virol 88:14222-31. 2014
    ..2-5As of sufficient length act as second messengers to activate RNase L and thereby restrict viral replication...
  84. pmc Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial
    Danyelle A Winchester
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
    Prostate 76:565-74. 2016
    ..In the present study, we evaluated the association between these SNPs and intraprostatic inflammation in men without a prostate cancer diagnosis...
  85. pmc Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses
    Yize Li
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 113:2241-6. 2016
    The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS...
  86. ncbi Development of a Scintillation Proximity Assay (SPA) Based, High Throughput Screening Feasible Method for the Identification of PDE12 Activity Modulators
    Samuel Mang
    Immunology and Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Stra 3e 65, 88400 Biberach an der Riss, Germany
    Curr Drug Discov Technol 13:144-151. 2016
    ..The method could facilitate the search for PDE12 inhibitors as antiviral compounds...
  87. doi Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension
    Sau Yeen Loke
    Department of Anatomy, National University of Singapore, 119260, Singapore
    Neurochem Int 102:33-56. 2016
    ..Up-regulated genes in the PFC of hypercholesterolemic rabbits included CIDEC, ODF2, RNASEL, FSHR, CES3 and MAB21L3, and down-regulated genes included FAM184B, CUL3, LOC100351029, TMEM109, LOC100357097 and ..
  88. pmc Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population
    Ignacio F San Francisco
    Departamento de Urologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Mol Med 18:125-33. 2014
    To study the association between the polymorphisms Arg462Gln and Asp541Glu from the RNASEL gene (1q25), and the polymorphisms rs620861, rs1447295, rs6983267, rs7837328 from the chromosome 8q24 with the risk of presenting prostate cancer (..
  89. ncbi Short interfering RNA confers intracellular antiviral immunity in human cells
    Leonid Gitlin
    Department of Microbiology and Immunology, Box 0414 and Program in Neuroscience, University of California, San Francisco, California 94143 0414, USA
    Nature 418:430-4. 2002
    ..classical antisense mechanisms or to interferon and the interferon response effectors protein kinase R (PKR) and RNaseL. Protection is the result of direct targeting of the viral genome by siRNA, as sequence analysis of escape virus (..
  90. ncbi Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus
    O V Masalova
    The Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Gamaleya Str 16, Moscow 123098, Russia
    Immunol Lett 83:187-96. 2002
    ..Six hybridoma clones producing monoclonal antibodies (MAB) to recombinant NS4 protein (rNS4), aa 1677-1756, were developed...
  91. pmc RNASEL mutations in hereditary prostate cancer
    H Chen
    J Med Genet 40:e21. 2003
  92. ncbi Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites
    Jian Qiu Han
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 24:664-76. 2004
    Ribonuclease L (RNase L) cleaves RNA predominantly at single-stranded UA and UU dinucleotides...
  93. ncbi Molecular biology in prostate cancer
    José Ramón Cansino Alcaide
    Urology Service, Hospital Universitario La Paz, Madrid, Spain
    Clin Transl Oncol 8:148-52. 2006
    ..Some genes have been found altered in prostate cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1 and those can be natural targets for new strategies of treatment...
  94. doi Structural changes of human RNase L upon homodimerization investigated by Raman spectroscopy
    Martin Kriz
    Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
    Biochim Biophys Acta 1824:1039-44. 2012
    b>RNase L, a key enzyme in the host defense system, is activated by the binding of 2'-5'-linked oligoadenylates (2-5A) to the N-terminal ankyrin repeat domain, which causes the inactive monomer to form a catalytically active homodimer...
  95. doi Innate immune messenger 2-5A tethers human RNase L into active high-order complexes
    Yuchen Han
    Department of Molecular Biology, Princeton University, 216 Schultz Laboratory, Princeton, NJ 08540, USA
    Cell Rep 2:902-13. 2012
    ..2-5As induce self-association and activation of RNase L, which cleaves cytosolic RNA and promotes the production of interferons (IFNs) and cytokines driven by the ..
  96. ncbi Evaluation of xenotropic murine leukemia virus and its R426Q polymorphism in patients with prostate cancer in Kerman, southeast of Iran
    Malekpour Afshar Reza
    Tropical and Infectious Disease Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Asian Pac J Cancer Prev 13:3669-73. 2012
    ..questions regarding the prevalence of XMRV in Iranian patients with prostate cancer and its association with the RNASEL R462Q polymorphism, we here investigated a series of cases in Kerman, in the Southeast of Iran, and sought to ..
  97. doi The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus
    Young Chan Kwon
    School of Life Sciences and Biotechnology, Korea University, Anam Dong 5 1, Seoul 136 701, Republic of Korea
    FEBS Lett 587:156-64. 2013
    The latent ribonuclease RNase L and the interferon-inducible 2',5'-oligoadenylate synthetase (OAS) have been implicated in the antiviral response against hepatitis C virus (HCV)...
  98. ncbi Expression, purification and characterization of the interferon-inducible, antiviral and tumour-suppressor protein, human RNase L
    Ankush Gupta
    Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    J Biosci 37:103-13. 2012
    The interferon (IFN)-inducible, 2',5'-oligoadenylate (2-5A)-dependent ribonuclease L (RNase L) plays key role in antiviral defense of mammalian cells...
  99. pmc Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements
    Latifa Al-Haj
    Program in BioMolecular Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Nucleic Acids Res 40:7739-52. 2012
    The p21(Cip1/WAF1) plays an important role in cell-cycle arrest. Here, we find that RNase L regulates p21-mediated G(1) growth arrest in AU-rich elements-dependent manner...
  100. pmc Mendelian inheritance of familial prostate cancer
    B S Carter
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD
    Proc Natl Acad Sci U S A 89:3367-71. 1992
    ..Characterization of genes involved in inherited prostate cancer could provide important insight into the development of this disease in general...
  101. pmc Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:4290-5. 1995
    We have isolated a unique genomic fragment encoding human ribonuclease 4 (RNase 4) of the mammalian ribonuclease gene family, whose members include pancreatic ribonuclease, eosinophil-derived neurotoxin, eosinophil cationic protein and ..

Research Grants28

  1. Susan R Weiss; Fiscal Year: 2016
    ..that confers antagonism of the potent antiviral 2',5'-oligoadenylate synthetase-ribonuclease L (OAS-RNaseL) pathway that is induced by IFN. In addition the highly neurovirulent JHM...
  2. Ila R Singh; Fiscal Year: 2014
    ..We found XMRV infection to be unrelated to a common polymorphism in the RNASEL gene, unlike previously reported...
  3. David J Barton; Fiscal Year: 2016
    ..The success of the poliovirus eradication campaign may depend upon improved poliovirus vaccines and new antiviral drugs. ..
  4. Cigarette Smoke, RIG-like Helicases and Alveolar Remodeling
    Jack A Elias; Fiscal Year: 2012
    ..the ability of RLH innate immune activation to activate both the PKR/eIF2[unreadable] and the 2',5'OAS/RNase L antiviral systems to simultaneously induce epithelial injury and inhibit progenitor cell-based repair responses...
  5. Infection with Bordetella pertussis exacerbates Influenza infection
    VICTOR ISAAC AYALA; Fiscal Year: 2010
    ..will examine gene expression for five IFN stimulated genes: protein kinase PKR, 2 ,5 -Oligoadenylate Synthetase, RNaseL, Adenosine deaminase (ADAR1) and MX protien GTPase by RT-PCR...
  6. Enterovirus RNA Translation and Replication
    David Barton; Fiscal Year: 2009
    ..These insights will be important for designing safe and effective vaccines for PV and other group C enteroviruses as well as antiviral drug therapies for many positive-strand RNA viruses. ..
  7. ANTIVIRAL ACTIONS OF INTERFERONS
    Ganes Sen; Fiscal Year: 1992
    ....
  8. Role of antiviral defense in autoimmune Type 1 Diabetes
    Vagn Bonnevie Nielsen; Fiscal Year: 2005
    ..antiviral enzyme 2'5'-oligoadenylate synthetase (2'5'AS), which in turn activates latent ribonuclease (RNAseL) leading to degradation of viral RNA...
  9. Alphavirus Minus Strand RNA Synthesis and RNase L
    DOROTHEA SAWICKI; Fiscal Year: 2009
    ..of a role for host functions, minus strand cessation did not occur in C7/10 mosquito cells that naturally lack RNase L and form persistent infections or in RNase L knockout (ko) mouse embryo fibroblasts (MEF) that are deficient in ..
  10. 2-5A Antisense for Degradation of SARS Coronavirus RNA
    Hagen Cramer; Fiscal Year: 2004
    ..2-5A antisense exploits a ubiquitous cellular ribonuclease L (RNase L), which is activated by binding to 2-5A...
  11. Tat-Driven Delivery of 2-5A Cargo for HIV RNA Ablation
    PAUL TORRENCE; Fiscal Year: 2003
    ..2-5A-dependent ribonuclease L (RNase L). This proposal seeks to target the 2-5A to HIV RNA by using the Tat peptide-HIV TAR RNA recognition sequence...
  12. 2-5A Antisense Targeting of Telomerase RNA
    Douglas Leaman; Fiscal Year: 2003
    ..and an activator moiety, 2?,5?-oligoadenylate (2-5A) that serve to activate a cellular enzyme, ribonuclease L (RNase L), which cleaves the targeted RNA...
  13. Screening for Rnase L Activators
    Hagen Cramer; Fiscal Year: 2004
    b>RNase L is a ubiquitous expressed latent ribonuclease, which is naturally activated by 2-5A (2',5' linked oligoadenylate). RNase L mediates antiviral and proapoptotic activities of interferon...
  14. Function of ISG15 during Viral Infection
    DEBORAH LENSCHOW; Fiscal Year: 2006
    ..While several of these genes, such as PKR, RNaseL, and Mx have been studied, hundreds of these genes still have no known function...
  15. Targeted Degradation of PKR mRNA with 2-5A Antisense
    Zan Xu; Fiscal Year: 2003
    ..and an activator moiety, 2',5'-oligoadenylate (2-5A) that serves to activate a cellular enzyme, ribonuclease L (RNase L), which cleaves the target RNA...
  16. Increasing 2-5A effectiveness through better chemistry
    Hagen Cramer; Fiscal Year: 2003
    ..and an activator moiety, 2',5'-oligoadenylate (2-5A) that serve to activate a cellular enzyme, ribonuclease L (RNase L), which cleaves the targeted RNA...
  17. Role of RNase L in the Biology of Prostate Cancer
    Robert Silverman; Fiscal Year: 2008
    ..IFN) antiviral pathways and prostate cancer genetics and have surprisingly converged on ribonuclease L (RNase L), a uniquely regulated enzyme that requires 5'-triphosphoryl, 2',5'- linked oligoadenylates (2-5A) ..
  18. Role of Phospholipid Scramblase in Interferon Action
    Robert Silverman; Fiscal Year: 2005
    ..abstract_text> ..
  19. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy R Rebbeck; Fiscal Year: 2010
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. ..
  20. Re-engineering the MEGA software package
    Sudhir Kumar; Fiscal Year: 2009
    ..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications. ..
  21. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2007
    ..abstract_text> ..
  22. Modifiers of Cancer Risk in BRCA 1/2 Mutation Carriers
    Timothy Rebbeck; Fiscal Year: 2008
    ..Our substantial multidisciplinary experience will therefore allow us to readily translate basic science and epidemiological data to clinically relevant information. ..
  23. Quantitative methods for genetic linkage heterogeneity
    Daniel Schaid; Fiscal Year: 2008
    ..Aim 3. User-friendly software: User-friendly software that implements the proposed methods, including well-documented procedures and examples of their usage, will be provided free to the scientific community. ..
  24. AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"
    William Nelson; Fiscal Year: 2005
    ..Support for this meeting will encourage the future development of urology research by providing mentoring for new investigators as well as education on this emerging research area. ..
  25. MECHANISM OF INDUCTION OF MALIGNANT GLIOMAS
    Demetrius Kokkinakis; Fiscal Year: 2002
    ..Genetic differences between tumor cells and those capable of infiltrating the normal parenchyma will also be identified and compared to those of initiated multipotent progenitor cells in order to understand their lineage. ..
  26. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
    ..The advantages of this proposed research, over those currently used to identify and characterize genes of complex diseases, are that it will offer a more powerful and flexible method to find these types of genes. ..
  27. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010
    ....
  28. ETIOLOGIC HETEROGENEITY IN LATE ONSET BREAST CANCER
    Timothy Rebbeck; Fiscal Year: 2001
    ..The results of these analyses will be used to attempt to elucidate the complex, multifactorial aetiology of late onset breast cancer. ..