RNASE4

Summary

Gene Symbol: RNASE4
Description: ribonuclease A family member 4
Alias: RAB1, RNS4, ribonuclease 4, RNase 4, ribonuclease A B1, ribonuclease, RNase A family, 4
Species: human

Top Publications

  1. pmc Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:4290-5. 1995
  2. doi Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology
    Ingrid T G W Bijsmans
    Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochim Biophys Acta 1863:687-700. 2016
  3. doi Bovine milk RNases modulate pro-inflammatory responses induced by nucleic acids in cultured immune and epithelial cells
    Sandeep K Gupta
    Dairy Foods, AgResearch, Ruakura Research Centre, Hamilton, New Zealand Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Dummerstorf, Germany Electronic address
    Dev Comp Immunol 68:87-97. 2017
  4. doi Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation
    Li Yu
    State Key Laboratory for Conservation and Utilization of Bio resource in Yunnan, Yunnan University, Kunming, China
    Nat Genet 48:947-52. 2016
  5. pmc Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats
    Xi Lan
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, PR China Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an, Shaanxi 710061, PR China
    Exp Biol Med (Maywood) 240:235-41. 2015
  6. pmc Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop
    Jinghao Sheng
    From the Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111 and
    J Biol Chem 289:12520-34. 2014
  7. ncbi Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25
    J Squire
    Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 19:174-5. 1994
  8. ncbi Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus
    O V Masalova
    The Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Gamaleya Str 16, Moscow 123098, Russia
    Immunol Lett 83:187-96. 2002
  9. pmc The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty
    Stephen M Goo
    Department of Biology, Creighton University
    Genome Biol Evol 5:2124-40. 2013
  10. pmc Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress
    Shuping Li
    Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Box 5069, Boston, MA 02111, USA
    Angiogenesis 16:387-404. 2013

Scientific Experts

  • Sandeep K Gupta
  • Jussi Naukkarinen
  • Thomas T Wheeler
  • Jinghao Sheng
  • Li Yu
  • Ingrid T G W Bijsmans
  • Xuan Wang
  • Xi Lan
  • Zhengping Xu
  • Guo fu Hu
  • Stephen M Goo
  • Shuping Li
  • Kenji Unno
  • Ya Ching Hsieh
  • Alexandra Milona
  • Xiao Ping Wang
  • Shao Chen Cheng
  • Hai Shu Li
  • Chung I Wu
  • Zheng Lin Du
  • Bing Bai
  • Na Yuan
  • Jing yuan Yang
  • Ya Ping Zhang
  • Shi Fang Wu
  • Xue Cao
  • Yan Hu Liu
  • Li Zhong
  • Guido J E J Hooiveld
  • Ellen C L Willemsen
  • Johan W Jonker
  • Oliver A Ryder
  • Saskia W C van Mil
  • Lu Wang
  • Guo Dong Wang
  • Cui Ping Yang
  • Hong Wu
  • Ying Li
  • Bao Guo Li
  • Kai Le Wang
  • Jue Ruan
  • Lu Fang
  • Jing Yang Hu
  • José M Ramos Pittol
  • Yong Cheng Long
  • Jing Yang
  • David M Irwin
  • Yong Bin Chen
  • Ye Qin Yang
  • Noortje Ijssennagger
  • Cheng Lin Zhang
  • Jin guo Zhang
  • Katja Lange
  • Dongmin Li
  • Shemin Lu
  • Bo Zhong
  • Yue Li
  • Li Liu
  • Lee Liu
  • Juan Ren
  • Qingzhu Sun
  • Chi Luo
  • O V Masalova
  • Philip W Hinds
  • Yuxiang Jiang
  • John E Landers
  • Hiroko Kishikawa
  • Wenhao Yu
  • Soochin Cho
  • Jamie K Hu
  • Kaori Shima
  • Winnie Xin
  • Katherine B Sims
  • Robert H Brown
  • Miaofen G Hu
  • David Wu
  • M Seno
  • S S Terzyan
  • H F Rosenberg
  • Katsuhiko Kitamoto
  • Praveen Rao Juvvadi
  • Harushi Nakajima
  • Katsuhiko Shirahige
  • Hseng Kuang Hsu
  • Yuh Man Sun
  • Pei Yi Lee
  • Y Tsushima
  • H Yamada
  • Rei Cheng Yang
  • A Egesten

Detail Information

Publications20

  1. pmc Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:4290-5. 1995
    We have isolated a unique genomic fragment encoding human ribonuclease 4 (RNase 4) of the mammalian ribonuclease gene family, whose members include pancreatic ribonuclease, eosinophil-derived neurotoxin, eosinophil cationic protein and ..
  2. doi Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology
    Ingrid T G W Bijsmans
    Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Biochim Biophys Acta 1863:687-700. 2016
    ..Finally, using organoids we identify Trpm6, Slc26a3, Ang1, and Rnase4, as novel Fxr target genes...
  3. doi Bovine milk RNases modulate pro-inflammatory responses induced by nucleic acids in cultured immune and epithelial cells
    Sandeep K Gupta
    Dairy Foods, AgResearch, Ruakura Research Centre, Hamilton, New Zealand Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand Leibniz Institute for Farm Animal Biology FBN, Institute for Genome Biology, Dummerstorf, Germany Electronic address
    Dev Comp Immunol 68:87-97. 2017
    ..Here we demonstrate that RNase4 and RNase5 purified from bovine milk bind to Salmonella typhimurium DNA and stimulate pro-inflammatory responses ..
  4. doi Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation
    Li Yu
    State Key Laboratory for Conservation and Utilization of Bio resource in Yunnan, Yunnan University, Kunming, China
    Nat Genet 48:947-52. 2016
    ..variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro...
  5. pmc Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats
    Xi Lan
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, PR China Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an, Shaanxi 710061, PR China
    Exp Biol Med (Maywood) 240:235-41. 2015
    ..expression of four genes (Alb, Pip4k2a, Scd1, and Tf) known to be associated with MetS and other five genes (Eif1, Rnase4, Rps12, Rup2, and Tmsb4) unknown to be relevant to MetS was significantly up-regulated in the livers of HFD-MetS ..
  6. pmc Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop
    Jinghao Sheng
    From the Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111 and
    J Biol Chem 289:12520-34. 2014
    Angiogenin (ANG) and ribonuclease 4 (RNASE4), two members of the secreted and vertebrate-specific ribonuclease superfamily, play important roles in cancers and neurodegenerative diseases...
  7. ncbi Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25
    J Squire
    Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
    Genomics 19:174-5. 1994
  8. ncbi Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus
    O V Masalova
    The Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Gamaleya Str 16, Moscow 123098, Russia
    Immunol Lett 83:187-96. 2002
    ..Six hybridoma clones producing monoclonal antibodies (MAB) to recombinant NS4 protein (rNS4), aa 1677-1756, were developed...
  9. pmc The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty
    Stephen M Goo
    Department of Biology, Creighton University
    Genome Biol Evol 5:2124-40. 2013
    ..Exemplifying this, bursts of gene duplication occurred for the RNase1, RNase4, and RNase5 genes of the little brown bat (Myotis lucifugus), which might have contributed to the species' ..
  10. pmc Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress
    Shuping Li
    Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Box 5069, Boston, MA 02111, USA
    Angiogenesis 16:387-404. 2013
    ..b>Ribonuclease 4 (RNASE4), the fourth member of this superfamily, shares the same promoters with ANG and is co-expressed with ..
  11. doi The mammalian secreted RNases: mechanisms of action in host defence
    Sandeep K Gupta
    AgResearch Ltd, Ruakura Research Centre, Hamilton, New Zealand
    Innate Immun 19:86-97. 2013
    ..to host defence, notably eosinophil-derived neurotoxin, eosinophil cationic protein, eosinophil-associated RNases, RNase4, angiogenin (RNase5), RNase7, RNase8 and bovine seminal RNase...
  12. doi Host-defence-related proteins in cows' milk
    T T Wheeler
    Food and Bio based Products Group, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3214, New Zealand
    Animal 6:415-22. 2012
    ..that do not have intrinsic antimicrobial activity is also discussed, notably lipopolysaccharide-binding protein, RNase4, RNase5/angiogenin and cartilage-glycoprotein 39 kDa...
  13. pmc Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes
    Jussi Naukkarinen
    FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Finland
    PLoS Genet 6:e1000976. 2010
    ..This study presents a new approach to utilizing gene expression studies for informing choice of candidate genes for complex human phenotypes, such as obesity...
  14. ncbi Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity
    R Shapiro
    Biochemistry 25:7255-64. 1986
    ..The liver enzymes, however, differ markedly from the HT-29 ribonuclease. The potential utility of the tumor ribonuclease in the diagnosis of cancer is considered...
  15. ncbi Identification and characterization of rns4/vps32 mutation in the RNase T1 expression-sensitive strain of Saccharomyces cerevisiae: Evidence for altered ambient response resulting in transportation of the secretory protein to vacuoles
    Kenji Unno
    Department of Biotechnology, University of Tokyo, Bunkyo ku, Japan
    FEMS Yeast Res 5:801-12. 2005
    ..In the present study, rns4 (VPS32/SNF7) gene mutation was identified by complementation of tunicamycin sensitivity...
  16. ncbi Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization
    Ya Ching Hsieh
    Department of Physiology, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
    Shock 21:549-55. 2004
    ..macroglobulin [alpha M]) and six down-regulated genes (hydroxysteroid dehydrogenase [3 alpha HSD], EST189895/mouse RNase4, bile acid-CoA-amino acid N-acyltransferase [kan-1/rBAT], IF1, albumin, and alpha 2u-globulins [alpha 2u-G PGCL1])...
  17. ncbi The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity
    S S Terzyan
    Centre d Investigació i Desenvolupament, C S I C, Jordi Girona, 18 26, Barcelona, 08034, Spain
    J Mol Biol 285:205-14. 1999
    The RNase 4 family is unique among RNase enzymes, displaying the highest level of sequence similarity and encompassing the shortest polypeptide chain. It is the only one showing high specificity...
  18. ncbi Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro
    A Egesten
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1358:255-60. 1997
    ..Using a polyclonal antiserum prepared against recombinant protein, we have detected one of these ribonucleases, RNase 4, in lysates of normal human peripheral blood monocytes, but not granulocytes or lymphocytes, by Western blotting...
  19. ncbi The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine
    H M Zhou
    Center for Biochemical and Biophysical Sciences and Medicine, Boston, MA 02115
    Eur J Biochem 217:401-10. 1993
    ..It is referred to as RNase 4, based on the nomenclature currently used for the genes of pancreatic RNase (RNase 1) and the eosinophil-derived ..
  20. ncbi Molecular cloning and expression of human ribonuclease 4 cDNA
    M Seno
    Department of Bioengineering Science, Faculty of Engineering, Okayama University, Japan
    Biochim Biophys Acta 1261:424-6. 1995
    A cDNA coding for human ribonuclease 4 was isolated from a pancreas cDNA library and sequenced. This cDNA (996 bp) includes an entire open reading frame encoding mature protein (119 aa) following signal peptide (28 aa)...