RNASE2

Summary

Gene Symbol: RNASE2
Description: ribonuclease A family member 2
Alias: EDN, RAF3, RNS2, non-secretory ribonuclease, RNase 2, RNase UpI-2, eosinophil-derived neurotoxin, ribonuclease 2, ribonuclease A F3, ribonuclease US, ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Species: human

Top Publications

  1. pmc Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease
    G J Gleich
    Proc Natl Acad Sci U S A 83:3146-50. 1986
  2. pmc Sequence variation at two eosinophil-associated ribonuclease loci in humans
    J Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 156:1949-58. 2000
  3. ncbi Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
    De Yang
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 102:3396-403. 2003
  4. pmc Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
  5. ncbi Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia
    Yae Jean Kim
    Laboratory of Malaria and Vector Research, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 73:125-30. 2005
  6. ncbi Urinary eosinophil-derived neurotoxin concentrations in patients with atopic dermatitis: a useful clinical marker for disease activity
    Tomoko Goto
    Gunma Institute for Allergy and Asthma, Shin Ohra Hospital, Gunma, Japan
    Allergol Int 56:433-8. 2007
  7. pmc Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
    De Yang
    Basic Research Program, SAIC Frederick, Inc, MD, USA
    J Exp Med 205:79-90. 2008
  8. ncbi Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily
    K J Hamann
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    Genomics 7:535-46. 1990
  9. ncbi Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes
    S Sur
    Department of Immunology, Mayo Clinic and Mayo Foundation, and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Leukoc Biol 63:715-22. 1998
  10. pmc Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions
    A Hatzelmann
    Byk Gulden, Department of Biochemistry, Konstanz, Germany
    Br J Pharmacol 114:821-31. 1995

Research Grants

  1. ANTIVIRAL EFFECTS OF EOSINOPHILS IN THE LUNGS
    David Jacoby; Fiscal Year: 2007
  2. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
  3. NOVEL THERAPY FOR KAPOSI'S SARCOMA
    JAMES LARRICK; Fiscal Year: 2000
  4. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
  5. Targeted Assisted Combinational Synthesis
    Steven Benner; Fiscal Year: 2004
  6. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
  7. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
  8. Apathy in Alzheimer's Disease Methylphenidate Trial
    Paul B Rosenberg; Fiscal Year: 2010
  9. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
  10. Risk Factors for Psychopathology in the WHO WMH Surveys
    Ronald Kessler; Fiscal Year: 2009

Detail Information

Publications179 found, 100 shown here

  1. pmc Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease
    G J Gleich
    Proc Natl Acad Sci U S A 83:3146-50. 1986
    Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion exchange chromatography on heparin-Sepharose...
  2. pmc Sequence variation at two eosinophil-associated ribonuclease loci in humans
    J Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 156:1949-58. 2000
    ..Here we present sequences of 2417 nucleotides at the two EAR loci, the eosinophil-derived neurotoxin (EDN, RNase 2) and eosinophil cationic protein (ECP, RNase 3), from >50 human individuals...
  3. ncbi Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
    De Yang
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 102:3396-403. 2003
    ..EDN was not chemotactic for leukocytes other than DCs. Mouse eosinophil-associated RNase 2 (mEAR2), one of a cluster of divergent orthologs of human EDN, was also chemotactic for human as well as mouse ..
  4. pmc Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
    ..Eosinophil granules contain an antimicrobial protein known as eosinophil-derived neurotoxin (EDN), which belongs to the RNase A superfamily. EDN has antiviral and chemotactic activities in vitro...
  5. ncbi Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia
    Yae Jean Kim
    Laboratory of Malaria and Vector Research, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 73:125-30. 2005
    Because eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India ..
  6. ncbi Urinary eosinophil-derived neurotoxin concentrations in patients with atopic dermatitis: a useful clinical marker for disease activity
    Tomoko Goto
    Gunma Institute for Allergy and Asthma, Shin Ohra Hospital, Gunma, Japan
    Allergol Int 56:433-8. 2007
    It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
  7. pmc Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
    De Yang
    Basic Research Program, SAIC Frederick, Inc, MD, USA
    J Exp Med 205:79-90. 2008
    Eosinophil-derived neurotoxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration and maturation of dendritic cells (DCs)...
  8. ncbi Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily
    K J Hamann
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    Genomics 7:535-46. 1990
    ..Alignment of EDN (RNS2) and ECP (RNS3) gene sequences demonstrated remarkable nucleotide similarities in noncoding sequences, introns, and ..
  9. ncbi Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes
    S Sur
    Department of Immunology, Mayo Clinic and Mayo Foundation, and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Leukoc Biol 63:715-22. 1998
    Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are generally regarded as eosinophil-specific proteins. We tested whether EDN and ECP are present in mature neutrophils...
  10. pmc Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions
    A Hatzelmann
    Byk Gulden, Department of Biochemistry, Konstanz, Germany
    Br J Pharmacol 114:821-31. 1995
    ..compounds on secretion of granule constituents (eosinophil cationic protein, ECP; eosinophil-derived neurotoxin, EDN) as well as on formation of reactive oxygen species measured by luminol-enhanced chemiluminescence in intact cells...
  11. ncbi Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis
    F W Tischendorf
    Department of Clinical Chemistry, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Acta Trop 72:157-73. 1999
    Eosinophils, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN/EPX), myeloperoxidase (MPO) and IgE were measured in blood, serum and/or urine in Schistosoma haematobium- and Onchocerca volvulus-infected Guineans and O...
  12. ncbi Expression and purification of recombinant rat eosinophil-associated ribonucleases, homologues of human eosinophil cationic protein and eosinophil-derived neurotoxin, and their characterization
    M Nakajima
    Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Int Arch Allergy Immunol 125:241-9. 2001
    ..contain two eosinophil ribonucleases, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN). In rats, 8 homologues of human ECP and EDN have been identified...
  13. ncbi Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis
    K Yamazaki
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Hepatology 30:71-8. 1999
    ..serum concentrations of eosinophil granule proteins (major basic protein [MBP] and eosinophil-derived neurotoxin [EDN]) by radioimmunoassay and quantitated eosinophil degranulation using computer-assisted morphometry after MBP ..
  14. ncbi Effect of interleukin-3, interleukin 5 and hyaluronic acid on cultured eosinophils derived from human umbilical cord blood mononuclear cells
    H Ohashi
    Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Takasaki
    Int Arch Allergy Immunol 118:44-50. 1999
    ..The aim of this study was to obtain large numbers of mature eosinophils from UCMC using IL-3, IL-5 and HA, and to investigate their functions...
  15. ncbi Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice
    N A Singhania
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
    J Mol Evol 49:721-8. 1999
    The two eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3), are among the most rapidly evolving coding sequences known among primates...
  16. ncbi Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene
    Kimberly D Dyer
    Eosinophil Pathophysiology Section, LHD, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 15:126-34. 2004
    ..that are highly divergent orthologs of the human eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3)...
  17. ncbi Human eosinophil-derived neurotoxin: involvement of a putative non-catalytic phosphate-binding subsite in its catalysis
    Deepa Sikriwal
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    Mol Cell Biochem 303:175-81. 2007
    Human eosinophil-derived neurotoxin (EDN) or RNase 2, found in the non-core matrix of eosinophils is a ribonuclease belonging to the Ribonuclease A superfamily...
  18. ncbi Eosinophils alter colonic epithelial barrier function: role for major basic protein
    Glenn T Furuta
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005
    ..supernatants contained the eosinophil-granule proteins major basic protein (MBP) and eosinophil-derived neurotoxin (EDN)...
  19. doi Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Leukoc Biol 85:719-27. 2009
    ..Also, CpG induced release of eosinophil-derived neurotoxin (EDN), and R-837 failed to do so...
  20. pmc High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors
    Demetres D Leonidas
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 11635 Athens, Greece
    Protein Sci 12:2559-74. 2003
    ..Comparative structural analysis of the RNase A, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and human angiogenin (Ang) complexes with these and other phosphonucleotide ..
  21. pmc Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 24:3507-13. 1996
    ..identified human ribonucleases of this group, RNase k6 is most closely related to eosinophil-derived neurotoxin (EDN), with 47% amino acid sequence identity; slight cross-reactivity between RNase k6 and EDN was observed on Western ..
  22. ncbi Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily
    M S Deming
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 8:599-607. 1998
    ..determined for the primate orthologs of the two closely related ribonucleases, the eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), which have incorporated nonsilent mutations at very rapid rates (1...
  23. ncbi Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens
    H F Rosenberg
    Eosinophil Biology Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 70:691-8. 2001
    ..Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil-associated ribonucleases (..
  24. ncbi Urinary eicosanoid and tyrosine derivative concentrations in patients with vasculitides
    Noritaka Higashi
    National Sagamihara Hospital, Sagamihara, Kanagawa, Japan
    J Allergy Clin Immunol 114:1353-8. 2004
    ..However, knowledge on inflammatory mediators and oxidative tissue damage associated with vasculitides is insufficient...
  25. ncbi Crystal structure of eosinophil cationic protein at 2.4 A resolution
    E Boix
    Department of Biology and Biochemistry, University of Bath, UK
    Biochemistry 38:16794-801. 1999
    ..which is about 100-fold lower than that of a related eosinophil ribonuclease, the eosinophil-derived neurotoxin (EDN). The crystal structure of human ECP, determined at 2.4 A, is similar to that of RNase A and EDN...
  26. ncbi The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site
    C Gopi Mohan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, U K
    Biochemistry 41:12100-6. 2002
    ..of the nucleotide recognition site in ECP and provides a starting point for the understanding of its substrate specificity and low catalytic efficiency compared with that of the eosinophil-derived neurotoxin (EDN), a close homologue.
  27. doi The effect of cationic charge on release of eosinophil mediators
    Darryl J Adamko
    Department of Pediatrics, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:383-90, 390.e1-4. 2008
    ..Although the role of cytokines in cell activation is well established, the presence of cationic-charged tissue can also be an important factor in inflammatory cell function...
  28. ncbi [Is the seric eosinophil cationic protein level a valuable tool of diagnosis in clinical practice?]
    D A Moneret-Vautrin
    Service de Medecine Interne, Immunologie Clinique et Allergologie, Hopital Universitaire, CHU de Nancy Hôpital Central, 54035 Nancy Cedex, France
    Rev Med Interne 27:679-83. 2006
    ..This summary considers the value of measuring ECP levels for the diagnosis of various diseases where an eosinophil-mediated tissue inflammation plays a role...
  29. ncbi The antipathogen activities of eosinophil cationic protein
    Ester Boix
    Departament Bioquimica i Biologia Molecular, Facultat Biociències, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain
    Curr Pharm Biotechnol 9:141-52. 2008
    ..antibacterial activity, which is not shared by the other, closely-related eosinophil ribonuclease, the eosinophil derived neurotoxin (EDN)...
  30. ncbi Familial eosinophilia: a benign disorder?
    Amy D Klion
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:4050-5. 2004
    ..Although levels of eosinophil-derived neurotoxin (EDN) and major basic protein (MBP) were elevated in patients with FE compared with NL, levels of both granule proteins ..
  31. ncbi A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma
    N Higashi
    Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Sagamihara, Kanagwa, Japan
    Clin Exp Allergy 32:1484-90. 2002
    ....
  32. pmc Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease
    Myeong Heon Shin
    Department of Parasitology, Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Korean J Parasitol 43:33-7. 2005
    ..products resulted in marked degranulation, as evidenced by the release of eosinophil-derived neurotoxin (EDN) in the culture supernatants. Moreover, superoxide anion was produced by eosinophils after stimulation of the ESP...
  33. pmc Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase
    Martina Ulrich
    Institute of Medical Microbiology and Hygiene, Universitatsklinikum Tubingen, Tübingen 72074, Germany
    J Biol Chem 283:28629-40. 2008
    ..that the human eosinophil toxins, eosinophil peroxidase (EPO), major basic protein, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), and the respective murine toxins, are post-translationally modified by ..
  34. pmc Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum
    Hyo Bin Kim
    Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    Chest 135:295-302. 2009
    ..To identify novel factors produced in the asthmatic airway, we analyzed sputum samples by using a membrane-based human cytokine microarray technology in patients with bronchial asthma (BA)...
  35. ncbi Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils
    Takao Fujisawa
    Department of Pediatrics and Allergy, National Mie Hospital, Tsu City, Japan
    J Asthma 39:21-7. 2002
    ..Levels of eosinophil-derived neurotoxin (EDN) in the supernatants were measured with radioimmunoassay...
  36. pmc Pimecrolimus reduces eosinophil activation associated with calcium mobilization
    Douglas A Plager
    Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4 94, 200 First Street Southwest, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 149:119-26. 2009
    ..However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Therefore, we examined the effects of pimecrolimus on eosinophil superoxide anion production, degranulation and survival...
  37. ncbi Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 186:1307-13. 2002
    ..with the onset of blood eosinopenia and preceding the appearance of plasma eosinophil-derived neurotoxin (EDN) and interleukin-5...
  38. ncbi Correlation of eosinophil derived neurotoxin with airway resistance in asthmatics
    Ahmed Badar
    Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
    J Pak Med Assoc 60:97-101. 2010
    To determine the correlation of EDN with lung function tests (FVC, FEV1, FEV1/FVC and FEF25-75%) in asthmatics and to compare these with matched controls.
  39. ncbi Eosinophil sequestration and activation are associated with the onset and severity of systemic adverse reactions following the treatment of onchocerciasis with ivermectin
    P J Cooper
    Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Infect Dis 179:738-42. 1999
    ..g., eosinophil-derived neurotoxin, EDN). After treatment, peripheral eosinophil counts declined in ivermectin-treated groups (P<...
  40. doi The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis
    Jungi Choi
    Department of Pediatrics and Inje University Sanggye Paik Hospital, Seoul, Korea
    Pediatr Allergy Immunol 21:474-9. 2010
    ..We also measured serum eosinophil-degranulation product (eosinophil-derived neurotoxin; EDN, eosinophil cationic protein; ECP) levels from RSV group...
  41. doi Role of catalytic and non-catalytic subsite residues in ribonuclease activity of human eosinophil-derived neurotoxin
    Deepa Sikriwal
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Biol Chem 390:225-34. 2009
    Human eosinophil-derived neurotoxin (EDN), a secretory protein from eosinophils, is a member of the RNase A superfamily. The ribonucleolytic activity of EDN is central to its biological activities...
  42. pmc GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene
    Zhijun Qiu
    Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:13099-109. 2009
    ..and GATA-2 in activating transcription of the secretory ribonuclease, the eosinophil-derived neurotoxin (EDN/RNase 2)...
  43. ncbi Eosinophil degranulation during pregnancy and after delivery by cesarean section
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 131:34-9. 2003
    ..present study, we investigated the degranulation of eosinophils and mast cells within the normal course of pregnancy and after delivery by measuring the urinary concentrations of eosinophil-derived neurotoxin (EDN) and N-methylhistamine.
  44. ncbi A synthetic peptide derived from the human eosinophil-derived neurotoxin induces apoptosis in Kaposi's sarcoma cells
    Anica Dricu
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Hospital, RS 00 17176, Stockholm, Sweden
    Anticancer Res 24:1427-32. 2004
    ..The eosinophil-derived neurotoxin ribonuclease, extended with four extra residues ((-4)EDN), has been suggested to be the putative anti-KS compound in the hCG preparations, being specifically recognized by ..
  45. pmc Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the future
    H F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Pharm Biotechnol 9:135-40. 2008
    The eosinophil-derived neurotoxin (EDN, also known as eosinophil protein-X) is best-known as one of the four major proteins found in the large specific granules of human eosinophilic leukocytes...
  46. pmc The roles of a Th2 cytokine and CC chemokine in children with stable asthma: potential implication in eosinophil degranulation
    Chang K Kim
    Pediatric Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    Pediatr Allergy Immunol 21:e697-704. 2010
    ..sputum levels of IL-5, eotaxin, and eosinophil indices [percentage eosinophils, eosinophil-derived neurotoxin (EDN), and eosinophil-cationic protein (ECP)]. We also examined correlations of IL-5 and eotaxin with eosinophil indices...
  47. doi Hepatocyte growth factor suppresses production of reactive oxygen species and release of eosinophil-derived neurotoxin from human eosinophils
    Wataru Ito
    Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan
    Int Arch Allergy Immunol 147:331-7. 2008
    Reactive oxygen species (ROS) and eosinophilic granule proteins such as eosinophil-derived neurotoxin (EDN) are known to damage bronchial tissue and cause airway hyperresponsiveness (AHR) in asthma...
  48. pmc Novel co-operation between eotaxin and substance-P in inducing eosinophil-derived neurotoxin release
    A El-Shazly
    Kumamoto University, School of Medicine, Department of Otolaryngology, Japan
    Mediators Inflamm 8:177-9. 1999
    ..we show that 10 ng/ml eotaxin primed normal human eosinophil for exaggerated eosonophil-derived neurotoxin (EDN) release stimulated by 10(-8) M Substance-P (SP)...
  49. doi A randomized intervention of montelukast for post-bronchiolitis: effect on eosinophil degranulation
    Chang Keun Kim
    Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    J Pediatr 156:749-54. 2010
    ..To investigate the effect of montelukast on eosinophil degranulation and recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis...
  50. ncbi In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins
    K J Hamann
    Department of Immunology, Mayo Medical School, Rochester, MN 55905
    J Immunol 144:3166-73. 1990
    ..granule proteins, namely, MBP, EPO, eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN), for the mf of Brugia pahangi and Brugia malayi...
  51. ncbi An analysis of mortality in the grower/finisher phase of swine production in the United States
    W C Losinger
    United States Department of Agriculture, Centers for Epidemiology and Animal Health, Fort Collins, CO 80521, USA
    Prev Vet Med 33:121-45. 1998
    ..SAS/STAT User's Guide, Version 6, 4th edn, Vol. 2. SAS Institute, Cary, NC, 794 pp...
  52. ncbi A survey of blood utilization in children and adolescents in a German university hospital
    R Zimmermann
    Abteilung für Transfusionsmedizin und Hämostaseologie, Friedrich Alexander Universitat, Erlangen Nurnberg, Germany
    Transfus Med 8:185-94. 1998
    ..formed from principal diagnoses of the recipients according to the International Classification of Diseases, 9th edn (ICD-9). 34.3% of 2869 RBC cell units, 35.0% of 1095 FFP units and 5...
  53. ncbi A heterozygous frameshift mutation in the endothelin-3 (EDN-3) gene in isolated Hirschsprung's disease
    P J Svensson
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Pediatr Res 45:714-7. 1999
    ..have so far been reported in five genes associated in two different receptor-ligand systems, RET-GDNF/NTN and EDNRB-EDN-3, and an additional gene with yet unknown precise function, SOX10...
  54. ncbi Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein
    S Taniuchi
    Department of Paediatrics, Kansai Medical University, Fumizonocho 10 15, Moriguchi, 570 8506, Osaka, Japan
    J Dermatol Sci 26:79-82. 2001
    ..However, the relationship between the disease severity and the eosinophil derived neurotoxin (EDN) has not been established in AD patients...
  55. ncbi Income and employment among homeless people: the role of mental health, health and substance abuse
    Samuel H Zuvekas
    Center for Cost and Financial Studies, Agency for Health Care Research and Quality, 2101 E Jefferson St, Ste 500, Rockville, MD 20852, USA
    J Ment Health Policy Econ 3:153-163. 2000
    ..criteria based on the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders 3rd edn (revised)...
  56. ncbi Trait and state aspects of harm avoidance and its implication for treatment in major depressive disorder, dysthymic disorder, and depressive personality disorder
    Kelley Yost Abrams
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, South Korea
    Psychiatry Clin Neurosci 58:240-8. 2004
    ..Subjects with Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) major depressive disorder (n = 39), dysthymic disorder (n = 37), depressive personality disorder (n = 39), ..
  57. ncbi Intra-episode hypomanic symptoms during major depression and their correlates
    Franco Benazzi
    Department of Psychiatry, National Health Service, Forli, Italy
    Psychiatry Clin Neurosci 58:289-94. 2004
    ..interviewed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV), Clinician Version (SCID-CV), as modified by Benazzi and Akiskal (J. Affect. Disord. 2003; 73: 33-38)...
  58. ncbi Expression and purification of human endostatin from Hansenula polymorpha A16
    Jiangxue Wu
    The Key Laboratory of Genetic Engineering of Ministry of Education, Department of Biochemistry, Sun Yat Sen University, Guangzhou, PR China
    Protein Expr Purif 42:12-9. 2005
    Endostatin (EDN), an endogenous angiogenesis inhibitor of 20 kDa, was originally isolated from the supernatant of culture murine hemangioendothelioma cell line...
  59. ncbi Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Psychiatry Clin Neurosci 59:497-503. 2005
    ..categories, schizophrenia and bipolar disorder, by the Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) criteria...
  60. doi Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia
    E Ono
    Clinical Research Centre for Allergy and Rheumatology, Sagamihara National Hospital, Sakuradai 18 1, Sagamihara, Kanagawa 228 8522, Japan
    Eur Respir J 32:437-42. 2008
    ..Leukotriene (LT)E(4), eosinophil-derived neurotoxin (EDN), 9alpha,11beta-prostaglandin F2 and LTB(4) glucuronide concentrations were quantified in the urine of: EP patients ..
  61. doi The endothelin system: evolution of vertebrate-specific ligand-receptor interactions by three rounds of genome duplication
    Ingo Braasch
    University of Wurzburg, Biozentrum, Physiological Chemistry I, Germany
    Mol Biol Evol 26:783-99. 2009
    ..We show that the endothelin core system, that is, endothelin ligands (Edn) and their receptors (Ednr), is a vertebrate-specific innovation...
  62. doi Triplex Doppler evaluation of uterine arteries in cyclic and pregnant domestic cats
    B S Pereira
    Laboratory of Carnivore Reproduction, Veterinary College, State University of Ceara, Fortaleza, CE, Brazil
    Anim Reprod Sci 130:99-104. 2012
    ..uterine horns, based on fetus number per horn; to determine the presence or absence of an early diastolic notch (EDN) in the uterine artery of pregnant queens...
  63. doi When is mass spectrometry combined with affinity approaches essential? A case study of tyrosine nitration in proteins
    Brînduşa Alina Petre
    Steinbeis Research and Transfer Center for Biopolymer Analysis, Department of Chemistry, University of Konstanz, Konstanz, Germany
    J Am Soc Mass Spectrom 23:1831-40. 2012
    ..granules from several biological samples, eosinophil-cationic protein (ECP) and eosinophil-derived neurotoxin (EDN)...
  64. doi Autism Spectrum Disorder Symptoms and Comorbidity in Emerging Adults
    Daniel L Gadke
    Department of Counseling and Educational Psychology, Mississippi State University, 508 Allen Hall, P O Box 9727, Mississippi State, MS, 39762, USA
    Child Psychiatry Hum Dev 47:194-201. 2016
    ..use of psychological testing for treatment planning and outcomes assessment: volume 3: instruments for adults, 3rd edn. Lawrence Erlbaum Associates, Mahwah, pp 115-152, 2004)...
  65. ncbi The eosinophil ribonucleases
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Mol Life Sci 54:795-803. 1998
    The eosinophil ribonucleases, eosinophilderived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are two closely related proteins with intriguing functional and evolutionary properties...
  66. ncbi Sulochrin inhibits eosinophil activation and chemotaxis
    H Ohashi
    Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Takasaki, Gunma, Japan
    Inflamm Res 47:409-15. 1998
    ..To evaluate the capacity of a novel compound, sulochrin, as an inhibitor of eosinophilic inflammation, we examined the effects of this compound on various effector functions of eosinophils...
  67. ncbi [Tic disorders in children and youth - part I]
    Z Gajewska-Zbiegien
    Zaklad Rozwoju Dzieci i Mlodziezy, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211 Warszawa, Poland
    Med Wieku Rozwoj 5:165-72. 2001
    ..disorders according to American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th edn. (1944) APA Washington. A general description of the clinical picture is given...
  68. ncbi A functional study on CysLT(1) receptors in human eosinophils
    Nobuharu Ohshima
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 129:67-75. 2002
    ..The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor...
  69. ncbi Behavioral and developmental disorders among conduct disorder
    Yuzuru Harada
    Mental Health Clinic for Children, Shinshu University Hospital, Matsumoto, Japan
    Psychiatry Clin Neurosci 56:621-5. 2002
    ..and their conditions were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV). Of the 33 children, 27 were diagnosed as having CD...
  70. pmc Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia
    Laura O'Bryan
    National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 71:1337-42. 2003
    ..factor, RANTES, or eosinophil cationic protein, there was a marked increase in eosinophil-derived neurotoxin (EDN) both systemically and in the lungs of individuals with TPE compared to each of the control groups (P < 0.02)...
  71. ncbi Monitoring the allergic inflammation
    P Venge
    Department of Medical Sciences, Clinical Chemistry and Asthma and Allergy Research Centre, Uppsala University, Uppsala, Sweden
    Allergy 59:26-32. 2004
    ..Measurement of eosinophil cationic protein (ECP) in sputum or blood and eosinophil protein X/eosinophil derived neurotoxin (EPX/EDN) in urine may be used to read the involvement of the eosinophil granulocyte in the process...
  72. ncbi Shah-Waardenburg syndrome and PCWH associated with SOX10 mutations: a case report and review of the literature
    Johanna B G M Verheij
    Department of Medical Genetics, University Medical Centre Groningen, Groningen University, Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Paediatr Neurol 10:11-7. 2006
    ..Mutations in the EDN, EDNRB and SOX10 genes can be found in patients with this syndrome...
  73. ncbi Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma
    Kyung Won Kim
    Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Biomolecule Secretion Research Center, Yonsei University College of Medicine, Seoul, Korea
    Lung 185:97-103. 2007
    This study sought to evaluate the use of serum eosinophil-derived neurotoxin (EDN), which has been proposed as a marker of airway inflammation in asthma in the diagnosis and evaluation of the severity and bronchial hyperresponsiveness in ..
  74. ncbi A study exploring UK midwives' knowledge and attitudes towards caring for women who have been sexually abused
    Karen B Jackson
    Academic Division of Midwifery, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Midwifery 25:253-63. 2009
    ..to investigate midwives' knowledge and attitudes in relation to caring for women who have been sexually abused...
  75. ncbi Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders
    Kayo Sato-Jin
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    FASEB J 22:1155-68. 2008
    ..transcription factor (MITF) is known to produce WS type IIA whereas mutations of either endothelin (EDN) or its receptor endothelin receptor B (EDNRB) produce WS type IV...
  76. ncbi Occupational exposure to cold thermal environments: a field study in Portugal
    A Virgílio M Oliveira
    Department of Mechanical Engineering, University of Coimbra, Polo II, 3030 788, Coimbra, Portugal
    Eur J Appl Physiol 104:207-14. 2008
    ..In order to characterize the level of cold exposure, the method proposed by ISO/TR 11079, Technical Report, 1st edn, International Organization for Standardization, Geneva (1993) was adopted...
  77. pmc DSM-IV-TR "pain disorder associated with psychological factors" as a nonhysterical form of somatization
    Massimiliano Aragona
    Faculty of Philosophy, University of Rome, La Sapienza, Italy
    Pain Res Manag 13:13-8. 2008
    ....
  78. doi Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis
    E Ono
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
    Clin Exp Allergy 39:72-80. 2009
    ..However, pathological evidence of the association between inflammatory mediators and human anaphylaxis is insufficient...
  79. pmc Roles of endothelin signaling in melanocyte development and melanoma
    Amy Saldana-Caboverde
    Department of Biological Sciences, Florida International University, Miami, FL, USA
    Pigment Cell Melanoma Res 23:160-70. 2010
    Endothelin (Edn) signaling via the G-coupled, Edn receptor type B (Ednrb) is essential for the development of melanocytes from the neural crest (NC) and has been associated with melanoma progression...
  80. pmc Eosinophil-derived neurotoxin is elevated in patients with amyotrophic lateral sclerosis
    Guan Ting Liu
    Graduate Institute of Molecular Systems Biomedicine, College of Medicine, China Medical University, Taichung 40402, Taiwan
    Mediators Inflamm 2013:421389. 2013
    ..molecular patterns, including reactive oxygen species, high-mobility group box 1, and eosinophil-derived neurotoxin (EDN), may participate in pathological conditions. In this study, we aim to discover new biomarker for detecting ALS.
  81. doi Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms
    Ki Sung Kim
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 130:553-66. 2013
    ..arch arteries and coronary arteries, the latter of which is also contributed by neural crest cells through an Edn-dependent mechanism...
  82. ncbi Suicide-related contacts--experience in general practice
    Christopher Harrison
    Australian GP Statistics and Classification Centre, University of Sydney, New South Wales
    Aust Fam Physician 42:605. 2013
    ..GP)-patient encounter where suicide ideation or attempt (International Classification of Primary Care 2nd edn, code P77) was recorded as either a problem under management or a patient's reason for encounter (RFE)...
  83. pmc Natural killer cells induce eosinophil activation and apoptosis
    Ali Awad
    Pulmonary Immunity, Institut National de la Sante et de la Recherche Medicale, Lille, France Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France CNRS UMR 8204, Lille, France Univ Lille Nord de France, Lille, France
    PLoS ONE 9:e94492. 2014
    ..evidenced by increased CD63 surface expression, secretion of eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN)...
  84. pmc The neural bases of cognitive processes in gambling disorder
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA Child Study Center, Yale University School of Medicine, New Haven, CT, USA Electronic address
    Trends Cogn Sci 18:429-38. 2014
    ..gambling disorder has recently been classified in the Diagnostic and Statistical Manual of Mental Disorders (5th edn) (DSM-5) as a behavioral addiction...
  85. doi Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes
    Phil June Park
    1 Bioscience Research Division, R and D Unit, AmorePacific Corporation, Yongin si, Gyeonggi Do, Republic of Korea 2 Department of Genetic Engineering, Sungkyunkwan University, Suwon Si, Gyeonggi Do, Republic of Korea
    J Invest Dermatol 135:551-9. 2015
    ..In addition to melanogenesis-related genes, the expression of neurokinin 1 receptor, endothelin 1 (EDN1), and EDN receptor type B (EDNRB) also increased at both the messenger RNA and protein levels...
  86. pmc Polymorphisms in endothelin system genes, arsenic levels and obesity risk
    Vanesa Martínez-Barquero
    Department of Medicine, University of Valencia, Valencia, Spain Genotyping and Genetic Diagnosis Unit, Hospital Clínico Research Foundation INCLIVA, Valencia, Spain
    PLoS ONE 10:e0118471. 2015
    Obesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (..
  87. pmc Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: A physiological implication in bovine oviduct immunity
    Mohamed Ali Marey
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    J Reprod Dev 62:151-7. 2016
    ..are regulated by autocrine/paracrine secretion of several factors, such as prostaglandins (PGs) and endothelin-1 (EDN-1)...
  88. doi Roles of EDNs in regulating oviductal NO synthesis and smooth muscle motility in cows
    Yoshihiko Kobayashi
    Laboratory of Reproductive PhysiologyGraduate School of Environmental and Life Science, Okayama University, Okayama, Japan
    Reproduction 151:615-22. 2016
    ..Quantification of mRNA expressions indicated that expression of EDN receptor B (EDNRB) in the ampullary region was higher after ovulation than before ovulation, whereas expression of ..
  89. doi Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities
    Ayush Attery
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Int J Biol Macromol 94:445-450. 2017
    ..contain two ribonucleases belonging to the RNase A family, eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN)...
  90. ncbi Laboratory tests for diagnosis of food allergy: advantages, disadvantages and future perspectives
    D A Moneret-Vautrin
    Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Avenue de Lattre de Tassigny 54035, Nancy
    Eur Ann Allergy Clin Immunol 35:113-9. 2003
    ..assays for leukotriene LTC4 release (CAST), measurement of plasma histamine, serum tryptase, serum ECP, urinary EDN, completed by mannitol-lactulose test evaluating intestinal permeability, assay of fecal IgEs, Rast for specific ..
  91. ncbi Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression
    Victoria I Bedoya
    Immunovirology Group, Universidad de Antioquia, Medelin, Colombia
    AIDS Res Hum Retroviruses 22:897-907. 2006
    ..The ribonuclease eosinophil-derived neurotoxin (EDN) is responsible for the anti-HIV-1 activity of a soluble factor produced in response to human alloantigens (ASF)...
  92. doi Differential activation of eosinophils by bacteria associated with asthma
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 161:16-22. 2013
    ..This study investigated whether bacteria exert differential effects on the functions of eosinophils, major effector cells in airway inflammation in asthma...
  93. pmc Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma
    Chang Keun Kim
    Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    Korean J Pediatr 56:8-12. 2013
    ..Elevated levels of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) have been noted in asthma patients...
  94. pmc Process and outcome constructs for evaluating community-based participatory research projects: a matrix of existing measures
    Jennifer A Sandoval
    University of Central Florida, Nicholson School of Communication, Orlando, FL 32816, USA
    Health Educ Res 27:680-90. 2012
    ..CBPR: What predicts outcomes? In: Minkler M, Wallerstein N (eds). Communication Based Participatory Research, 2nd edn. San Francisco, CA: John Wiley & Co...
  95. ncbi Characterization of a unique nonsecretory ribonuclease from urine of pregnant women
    R Sakakibara
    Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University
    J Biochem 111:325-30. 1992
    ..These results suggest the possibility that RNase UpI-2 may have been formed via a specific protein modification in pregnant women...
  96. pmc Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity
    H F Rosenberg
    Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts
    J Exp Med 170:163-76. 1989
    ..shows 89% sequence identity with that reported for the related granule protein, eosinophil-derived neurotoxin (EDN)...
  97. ncbi Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases
    K J Hamann
    Department of Immunology, Mayo Clinic and Foundation, Rochester, MN 55905
    Gene 83:161-7. 1989
    Several clones of human eosinophil-derived neurotoxin (EDN) cDNA have been isolated from a lambda gt10 cDNA library prepared from mRNA derived from noninduced HL-60 cells...
  98. pmc Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family
    H F Rosenberg
    Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215
    Proc Natl Acad Sci U S A 86:4460-4. 1989
    We have isolated a 725-base-pair cDNA clone for human eosinophil-derived neurotoxin (EDN)...
  99. ncbi Localization of IGF1R and EDN genes to pig chromosomes 1 and 7 by in situ hybridization
    Y Lahbib-Mansais
    Laboratoire de Genetique Cellulaire, Centre INRA Toulouse, Castanet Tolosan, France
    Cytogenet Cell Genet 71:225-7. 1995
    ..insulin-like growth factor-1 receptor (IGF1R) and a porcine endothelium-derived 21-residue vasoconstrictor peptide (EDN) were localized in the pig by means of radioactive in situ hybridization. IGF1R was mapped to chromosome region 1q1...
  100. pmc Characterisation of UGP and its relationship with beta-core fragment
    A Kardana
    Department of Medical Oncology, Charing Cross Hospital, London, UK
    Br J Cancer 67:686-92. 1993
    ..N-terminus of peptide 3 that was sequenced showed complete homology with the N-terminal sequence of eosinophil derived neurotoxin and non-secretory ribonuclease...

Research Grants23

  1. ANTIVIRAL EFFECTS OF EOSINOPHILS IN THE LUNGS
    David Jacoby; Fiscal Year: 2007
    ..Eosinophil ribonucleases (eosinophil derived neurotoxin (EDN) and eosinophil cationic protein (ECP)) may also participate...
  2. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..and function of eosinophil granule proteins, including major basic protein (MBP1), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO)...
  3. NOVEL THERAPY FOR KAPOSI'S SARCOMA
    JAMES LARRICK; Fiscal Year: 2000
    ..on the remarkable finding that a four amino acid extension of a human ribonuclease, eosinophil-derived neurotoxin [EDN(-4)], accounts for much of the cytotoxic activity of crude human chorionic gonadotropin for Kaposi's sarcoma cells ...
  4. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    The goal of the proposed studies is to elucidate the mechanism of endothelin-2 (EDN-2) action in follicle rupture...
  5. Targeted Assisted Combinational Synthesis
    Steven Benner; Fiscal Year: 2004
    ..cancer, and a variety of other diseases; (b) the eosinophil cationic proteirdeosinophil-derived neurotoxin (ECP/EDN) family, which plays key roles in allergy, anaphylaxis, and inflammation...
  6. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  7. Selegiline for Smoking Cessation
    MARC POTENZA; Fiscal Year: 2007
    ..Positive results from this trial would add further support for the safety and efficacy of selegiline for the treatment of nicotine dependence. ..
  8. Apathy in Alzheimer's Disease Methylphenidate Trial
    Paul B Rosenberg; Fiscal Year: 2010
    ..This study aims to develop a new treatment for apathy in AD that could decrease its debilitating consequences and reduce patients'dependency on caregivers, providing well-deserved relief to patients and their loved ones. ..
  9. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
    ..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..
  10. Risk Factors for Psychopathology in the WHO WMH Surveys
    Ronald Kessler; Fiscal Year: 2009
    ..Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments. ..
  11. fMRI of Craving in Addictions: Gender Differences
    MARC POTENZA; Fiscal Year: 2009
    ..abstract_text> ..
  12. Taurine and Painful Diabetic Neuropathy
    Martin Stevens; Fiscal Year: 2007
    ..These studies will test a novel mechanistically based therapeutic approach to a common disabling and often-refractory complication of diabetes. ..
  13. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..As an alternative, if in aim 1 little correlation between hTT mRNA abundance and hTT activity is found, then glucose mediated post-translational modifications will be examined. ..
  14. Depressoin in Alzheimer's Disease Study-2 (DIADS-2)
    Jacobo Mintzer; Fiscal Year: 2007
    ..abstract_text> ..
  15. Institute for Research Minority Training on Mental Health
    Jacobo Mintzer; Fiscal Year: 2007
    ..We expect this effort to be the incubator for a new generation of minority researchers dedicated to the study mental health and aging. ..
  16. Quantifying the Value of Value-Based Purchasing
    Ronald Kessler; Fiscal Year: 2006
    ..abstract_text> ..
  17. Outreach and Treatment for Depression in the Labor Force
    Ronald Kessler; Fiscal Year: 2005
    ..This is an extremely important opportunity for rapid and widespread dissemination in an area of research where dissemination of positive results has traditionally been a serious problem. ..
  18. Ventilator-Induced Lung Injury in Children
    Sabrina Heidemann; Fiscal Year: 2004
    ..The results of this study may serve as the basis for a multicenter clinical trial. ..
  19. Hurricane Katrina Community Advisory Group
    Ronald C Kessler; Fiscal Year: 2010
    ....
  20. MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERS
    Ronald Kessler; Fiscal Year: 2003
    ....
  21. Cellular Quiescence and Brain Tumor Stem Cells
    Cho Lea Tso; Fiscal Year: 2009
    ....
  22. Urine Protein Biomarker Exploration in Ovarian Cancer
    Bin Ye; Fiscal Year: 2006
    ..This project, if successful, could fundamentally shift the approach to the early detection of ovarian cancer and significantly improve the survival rate of cases detected. [unreadable] [unreadable]..