Genomes and Genes
Gene Symbol: rhodopsin
Alias: CSNBAD1, OPN2, RP4, opsin 2, rod pigment, opsin-2
Publications283 found, 100 shown here
- Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapyHugo F Mendes
Division of Pathology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
Trends Mol Med 11:177-85. 2005..Mutations in rhodopsin are the most common cause of autosomal-dominant RP (ADRP)...
- BiP prevents rod opsin aggregationDimitra Athanasiou
UCL Institute of Ophthalmology, London, United Kingdom
Mol Biol Cell 23:3522-31. 2012..Therefore inhibition of BiP function results in aggregation of rod opsin in the ER, which suggests that BiP is important for maintaining the solubility of rod opsin in the ER...
- Rhodopsin mutation G90D and a molecular mechanism for congenital night blindnessV R Rao
Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254
Nature 367:639-42. 1994Mutations in the gene for the visual pigment rhodopsin cause retinitis pigmentosa (RP) and congenital night blindness...
- Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculationsElizabeth P Rakoczy
University of Western Australia, Crawley, Western Australia, Australia
J Mol Biol 405:584-606. 2011..A total of 103 mutations in rhodopsin are linked to RP to date, and the phenotypes range from severe to asymptomatic...
- SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rodsJen Zen Chuang
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Cell 130:535-47. 2007..cilium containing approximately 1,000 stacked disc membranes that are densely packed with visual pigment rhodopsin. The mammalian OS is renewed every ten days; new discs are assembled at the base of the OS by a poorly ..
- Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexesJen Zen Chuang
Department of Ophthalmology, The Margaret M Dyson Research Institute, New York, NY 10021, USA
J Clin Invest 114:131-40. 2004..Mutations at Arg135 of rhodopsin are associated with a severe form of autosomal dominant RP...
- Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNBChristina Zeitz
Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 49:4105-14. 2008..The study was conducted to identify the genetic defect in a large Swiss family affected with adCSNB and to investigate the pathogenic mechanism of the mutation...
- Molecular mechanisms of disease for mutations at Gly-90 in rhodopsinDarwin Toledo
Centre de Biotecnologia Molecular, Departament d Enginyeria Quimica, Universitat Politecnica de Catalunya, 08222 Terrassa, Spain
J Biol Chem 286:39993-40001. 2011Two different mutations at Gly-90 in the second transmembrane helix of the photoreceptor protein rhodopsin have been proposed to lead to different phenotypes...
- Autosomal dominant sectoral retinitis pigmentosa. Two families with transversion mutation in codon 23 of rhodopsinJ R Heckenlively
Jules Stein Eye Institute, UCLA School of Medicine 90024
Arch Ophthalmol 109:84-91. 1991A cytosine-to-adenine transversion in codon 23 of rhodopsin, the rod visual pigment gene, was reported recently by Dryja et al in 17 of 148 unrelated patients with autosomal dominant retinitis pigmentosa, but the clinical findings ..
- A new codon 15 rhodopsin gene mutation in autosomal dominant retinitis pigmentosa is associated with sectorial diseaseL J Sullivan
Department of Ophthalmology, University of Melbourne, Australia
Arch Ophthalmol 111:1512-7. 1993To ascertain and characterize rhodopsin gene mutations in autosomal dominant retinitis pigmentosa and to correlate these mutations with the clinical phenotypes.
- Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
N Engl J Med 323:1302-7. 1990Night blindness is an early symptom of retinitis pigmentosa. The rod photoreceptors are responsible for night vision and use rhodopsin as the photosensitive pigment.
- A dual role for EDEM1 in the processing of rod opsinMaria Kosmaoglou
UCL Institute of Ophthalmology, London, UK
J Cell Sci 122:4465-72. 2009....
- Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindnessT P Dryja
Berman Gund Laboratory, Harvard Medical School, Boston, Massachusetts 02114
Nat Genet 4:280-3. 1993A number of mutations in the rhodopsin gene have been shown to cause both dominant and recessive retinitis pigmentosa. Here we describe another phenotype associated with a defect in this gene...
- Structure and function in rhodopsin: further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and functionJ Hwa
Departments of Biology and Chemistry, Massachusetts Institute of Technology 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 96:1932-5. 1999..Cys-110 and Cys-187 in the intradiscal domain is required for correct folding in vivo and function of mammalian rhodopsin. Misfolding in rhodopsin, characterized by the loss of ability to bind 11-cis-retinal, has been shown to be ..
- A point mutation of the rhodopsin gene in one form of retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
Nature 343:364-6. 1990..As the gene coding for rhodopsin is also assigned to the long arm of chromosome 3 and is expressed in rod photoreceptors that are affected early ..
- A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindnessN al-Jandal
Wellcome Ocular Genetics Unit, Trinity College, Dublin, Ireland
Hum Mutat 13:75-81. 1999More than 100 mutations within the rhodopsin gene have been found to be responsible for some forms of retinitis pigmentosa, a progressive retinal degeneration characterized by night blindness and subsequent disturbance of day vision that ..
- Description of a new mutation in rhodopsin, Pro23Ala, and comparison with electroretinographic and clinical characteristics of the Pro23His mutationK T Oh
Department of Opthamology and Visual Science, University of Iowa Hospitals and Clinics, Iowa City, USA
Arch Ophthalmol 118:1269-76. 2000..autosomal dominant retinitis pigmentosa caused by a proline-to-alanine mutation at codon 23 (Pro23Ala) of the rhodopsin gene and to compare this phenotype with that associated with the more common proline-to-histidine mutation at ..
- Identification of a new mutation at codon 171 of rhodopsin gene causing autosomal dominant retinitis pigmentosaG Antinolo
Unidad de Genética Médica, Hospital Universitario Virgen del Rocio, Sevilla, Spain
Hum Mol Genet 3:1421. 1994
- Ocular findings associated with a rhodopsin gene codon 106 mutation. Glycine-to-arginine change in autosomal dominant retinitis pigmentosaG A Fishman
Department of Ophthalmology, University of Illinois, Chicago 60612
Arch Ophthalmol 110:646-53. 1992..family were found to have a guanine-to-adenine transition mutation in the first nucleotide of codon 106 in the rhodopsin gene that results in a glycine-to-arginine change...
- Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)K Fujiki
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Jpn J Hum Genet 37:125-32. 1992The mutations of codon 17, 23, 58, and 347 of rhodopsin gene were investigated in 24 unrelated Japanese families including 33 patients with autosomal dominant retinitis pigmentosa (ADRP)...
- Mutation spectrum and frequency of the RHO gene in 248 Chinese families with retinitis pigmentosaShiqiang Li
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
Biochem Biophys Res Commun 401:42-7. 2010Mutations in the rhodopsin gene (RHO) are suggested to be the most common cause of autosomal dominant retinitis pigmentosa (RP)...
- Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosaKwang Joong Kim
Center for Genome Science, National Institute of Health, Chungcheongbuk Do, Korea
Mol Vis 17:844-53. 2011To determine the spectrum and frequency of rhodopsin gene (RHO) mutations in Korean patients with retinitis pigmentosa (RP) and to characterize genotype-phenotype correlations in patients with mutations.
- Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsinH Kranich
Institut fur Humangenetik, Medizinische Universitat, Lubeck, Germany
Hum Mol Genet 2:813-4. 1993
- Novel PRPF31 and PRPH2 mutations and co-occurrence of PRPF31 and RHO mutations in Chinese patients with retinitis pigmentosaKing Poo Lim
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Arch Ophthalmol 127:784-90. 2009..To screen mutations in the PRPF31, RHO, and PRPH2 genes in Chinese patients with retinitis pigmentosa (RP)...
- IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNASarah E Mortimer
Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Biol Chem 283:36354-60. 2008..Finally, we find that IMPDH1 is associated with polyribosomes containing rhodopsin mRNA...
- A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segmentC H Sung
Department of Molecular Biology and Genetics, Johns Hopkins Medical School, Baltimore, Maryland 21205
J Neurosci 14:5818-33. 1994Over 45 mutations in the rhodopsin gene have been identified in patients with autosomal dominant retinitis pigmentosa, including a cluster near the extreme carboxy-terminus, a region of the protein for which no function has yet been ..
- Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosaC Reig
Secció de Genética del Hospital Sant Joan de Déu, Barcelona, Spain
Hum Genet 94:283-6. 1994..Approximately 30% of ADRP patients show point mutations or small deletions in the rhodopsin gene. However, over 50% of the RP patients are simplex cases (sporadic)...
- A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosaC F Inglehearn
Department of Human Genetics, University of Newcastle upon Tyne, England
Am J Hum Genet 48:26-30. 1991..The gene encoding rhodopsin, the rod photoreceptor pigment, is closely linked to locus D3S47 on chromosome 3q...
- Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked familyG J Farrar
Department of Genetics, Trinity College Dublin, Ireland
Hum Mol Genet 1:769-71. 1992
- Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosaJ E Olsson
Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
Neuron 9:815-30. 1992..a mutant or wild-type allele from a patient with retinitis pigmentosa and a missense mutation (P23H) in the rhodopsin gene...
- Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCPAna Griciuc
Department of Protein Science, Helmholtz Zentrum Muenchen German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
Biochim Biophys Acta 1803:424-34. 2010Dominant mutations in the visual pigment Rhodopsin (Rh) cause retinitis pigmentosa (RP) characterized by progressive blindness and retinal degeneration...
- Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment siteT J Keen
Molecular Genetics Unit, Department of Human Genetics, Newcastle upon Tyne, United Kingdom
Genomics 11:199-205. 1991Several mutations in the rhodopsin gene in patients affected by autosomal dominant retinitis pigmentosa (ADRP) have recently been described...
- Altered functionality in rhodopsin point mutants associated with retinitis pigmentosaAnna Andrés
Unitat de Biofisica, Departament de Bioquimica i de Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Catalonia, Spain
Biochem Biophys Res Commun 303:294-301. 2003Point mutations found in rhodopsin associated with the retinal degenerative disease retinitis pigmentosa have been expressed in mammalian COS-1 cells, purified, and characterised...
- Mutational analysis of the rhodopsin gene in Chinese ADRP families by conformation sensitive gel electrophoresisXiao L Zhang
Center for Molecular Diagnosis and Gene Therapy, Affiliated South West Hospital, Third Military Medical University, Chongqing, PR China
Life Sci 78:1494-8. 2006..For autosomal dominant retinitis pigmentosa (ADRP), the most common gene is the rhodopsin (RHO) gene, mutations in which contribute to about 25% of ADRP in Caucasian population...
- Rhodopsin mutations in autosomal dominant retinitis pigmentosaC H Sung
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 88:6481-5. 1991..161 unrelated patients with autosomal dominant retinitis pigmentosa were screened for point mutations in the rhodopsin gene by using the polymerase chain reaction and denaturing gradient gel electrophoresis...
- Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chainC H Sung
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
J Biol Chem 268:26645-9. 1993Over 40 mutations in the rhodopsin gene have been identified in patients with autosomal dominant retinitis pigmentosa...
- The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formationJ Paul Chapple
Division of Pathology, Institute of Ophthalmology, University College of London, London EC1V 9EL, United Kingdom
J Biol Chem 278:19087-94. 2003..Because of their enrichment at the site of rhodopsin production, we investigated the effect of HSJ1 isoforms on the cellular processing of wild-type and mutant ..
- Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutationsS G Jacobson
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, FL 33101
Am J Ophthalmol 112:256-71. 1991..autosomal dominant retinitis pigmentosa, who represented five different point mutations in the gene encoding rhodopsin. In a family with a stop codon mutation at the carboxyl end of the molecule (glutamine-344), young members with ..
- Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosaT P Dryja
Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston
Proc Natl Acad Sci U S A 88:9370-4. 1991We searched for point mutations in every exon of the rhodopsin gene in 150 patients from separate families with autosomal dominant retinitis pigmentosa...
- A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemMichelle E Illing
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
J Biol Chem 277:34150-60. 2002..30-40% of human autosomal dominant (AD) RP is caused by dominantly inherited missense mutations in the rhodopsin gene...
- Retinitis pigmentosa: mutation analysis of RHO, PRPF31, RP1, and IMPDH1 genes in patients from IndiaMamatha Gandra
Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya Chennai, India
Mol Vis 14:1105-13. 2008To screen for possible disease-causing mutations in rhodopsin (RHO), pre-mRNA processing factor 31 (PRPF31), retinitis pigmentosa 1 (RP1), and inosine monophosphate dehydrogenase 1 (IMPDH1) genes in Indian patients with isolated and ..
- A two-stage approach identifies a Q344X mutation in the rhodopsin gene of a Chinese Singaporean family with autosomal dominant retinitis pigmentosaR Y Y Yong
Centre for Biomedical Sciences, Defence Medical and Enviromental Research Institute, DSO National Laboratories, Singapore
Ann Acad Med Singapore 34:94-9. 2005..Using a two-stage approach by combining linkage analysis with mutation detection, we have rapidly identified the gene locus and the mutation site of a Chinese Singaporean family with autosomal dominant RP...
- Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosaRahul S Rajan
Departments of Chemistry and Biological Sciences, Stanford University, Stanford, California 94305 5430, USA
J Biol Chem 280:1284-91. 2005Autosomal dominant retinitis pigmentosa (ADRP) has been linked to mutations in the gene encoding rhodopsin. Most RP-linked rhodopsin mutants are unable to fold correctly in the endoplasmic reticulum, are degraded by the ubiquitin ..
- Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsinJ P Macke
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Am J Hum Genet 53:80-9. 1993Ten rhodopsin mutations have been found in a screen of 282 subjects with retinitis pigmentosa (RP), 76 subjects with Leber congenital amaurosis, and 3 subjects with congenital stationary night blindness...
- Missense rhodopsin mutation in a family with recessive RPG Kumaramanickavel
Nat Genet 8:10-1. 1994
- Rhodopsin mutations in autosomal dominant retinitis pigmentosaM Al-Maghtheh
Department of Molecular Genetics, University of London, England
Hum Mutat 2:249-55. 1993..cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade...
- Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutationP A Sieving
Department of Ophthalmology, University of Michigan, Ann Arbor 48105
Proc Natl Acad Sci U S A 92:880-4. 1995A human rhodopsin mutation, Gly-90-->Asp (Gly90Asp), cosegregated with an unusual trait of congenital nightblindness in 22 at-risk members of a large autosomal dominant kindred...
- Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresisV C Sheffield
Department of Pediatrics, University of Iowa, Iowa City
Am J Hum Genet 49:699-706. 1991..of RP has been the recognition that some cases of autosomal dominant RP (ADRP) are caused by mutations in the rhodopsin gene...
- Linkage analysis and mutation screening of the rhodopsin gene in a Chinese Bai family with autosomal dominant retinitis pigmentosaHaike Guo
Department of Ophthalmology, Guangdong Eye Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong, PR China
J Hum Genet 55:571-6. 2010Autosomal dominant retinitis pigmentosa (adRP) is a common form of RP worldwide. Although rhodopsin (RHO) is the most frequently reported adRP gene in many populations, it has not been detected in patients from the Bai nationality, one ..
- Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190NIrena Tsui
Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, California, USA
Curr Eye Res 33:1014-22. 2008..To phenotype a family with RHO (Asp190Asn or D190N) dominantly inherited retinitis pigmentosa (RP) and to describe an approach to surveying affected families...
- Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinalSyed M Noorwez
Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 284:33333-42. 2009..Mutations of rhodopsin, the glycoprotein pigment of rod photoreceptors, cause misfolding resulting in retinitis pigmentosa...
- A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosaMaleeha Azam
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
Mol Vis 15:2526-34. 2009..To identify the gene mutations responsible for autosomal recessive retinitis pigmentosa (arRP) in Pakistani families...
- Mutation screening and haplotype analysis of the rhodopsin gene locus in Japanese patients with retinitis pigmentosaYuichiro Ando
Department of Rehabilitation Engineering, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan
Mol Vis 13:1038-44. 2007To identify nucleotide sequence variations in the rhodopsin (RHO) gene of Japanese patients with retinitis pigmentosa (RP) in order to search for mutations or haplotypes responsible for RP.
- Spectrum of rhodopsin mutations in French autosomal dominant rod-cone dystrophy patientsIsabelle Audo
INSERM, U968, Paris, France
Invest Ophthalmol Vis Sci 51:3687-700. 2010PURPOSE. To identify the prevalence of rhodopsin (RHO) mutations in French patients with autosomal dominant rod-cone dystrophies (adRPs). Methods...
- Mutation analysis of codons 345 and 347 of rhodopsin gene in Indian retinitis pigmentosa patientsM Dikshit
Division of Biochemistry, Department of Chemistry, University of Pune, Pune 411 007, India
J Genet 80:111-6. 2001More than 100 mutations have been reported till date in the rhodopsin gene in patients with retinitis pigmentosa...
- Different amino acid substitutions at the same position in rhodopsin lead to distinct phenotypesJohn Neidhardt
University of Zurich, Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, Schwerzenbach, Switzerland
Invest Ophthalmol Vis Sci 47:1630-5. 2006Identification of a novel rhodopsin mutation in a family with retinitis pigmentosa and comparison of the clinical phenotype to a known mutation at the same amino acid position.
- Isolation and nucleotide sequence of the gene encoding human rhodopsinJ Nathans
Proc Natl Acad Sci U S A 81:4851-5. 1984We have isolated and completely sequenced the gene encoding human rhodopsin. The coding region of the human rhodopsin gene is interrupted by four introns, which are located at positions analogous to those found in the previously ..
- A complete screen for mutations of the rhodopsin gene in a panel of Chinese patients with autosomal dominant retinitis pigmentosaXiao Li Zhang
Clinical Laboratory Center, Affiliated South West Hospital, Third Military Medical University, Chongqing 400038
Chin Med Sci J 20:30-4. 2005To evaluate the prevalence of rhodopsin (RHO) mutations and the genotype-phenotype relationships in Chinese patients with autosomal dominant retinitis pigmentosa (ADRP) by conformation sensitive gel electrophoresis (CSGE) and direct DNA ..
- Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approachM S Gorbatyuk
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
Mol Vis 11:648-56. 2005To develop a hammerhead ribozymes (Rz) that might be exploited in a "digest and replace" gene therapy strategy for autosomal dominant retinitis pigmentosa (ADRP) caused by mutations in the gene for rhodopsin (RHO).
- Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibitionR Dechend
, , Humboldt University of Berlin, Germany
Am J Hypertens 14:55S-61S. 2001..These data may in part explain cholesterol-independent, HMG-CoA reductase-related, protective effects...
- Vaginal topography does not correlate well with visceral position in women with pelvic organ prolapseK Kenton
Rush Medical College, Chicago, IL 60612-3873, USA
Int Urogynecol J Pelvic Floor Dysfunct 8:336-9. 1997..67 and rho = 0.55, respectively). It was concluded that vaginal topography does not reliably predict the position of the associated viscera on PFF in women with primary or recurrent pelvic organ prolapse...
- Cloning and analysis of YMR26, the nuclear gene for a mitochondrial ribosomal protein in Saccharomyces cerevisiaeW Kang
Graduate School of Science and Technology, Faculty of Science, Kobe University, Japan
Mol Gen Genet 225:474-82. 1991..However, in rho o cells, its transcription appeared not to be repressed even by high concentrations of glucose. The amount of the YMR26 mRNA was increased 10-fold when cells carried the YMR26 gene on a high-copy number plasmid...
- Caffeine consumption in hospitalized psychiatric patientsM Rihs
Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Lausanne, Switzerland
Eur Arch Psychiatry Clin Neurosci 246:83-92. 1996..Our data suggest that inquiry into caffeine consumption should be included routinely for psychiatric patients, e.g. at admission, because patients with a psychotic disorder undergo a higher risk for an excessive caffeine consumption...
- Cocaine elicits action potential bursts in a central snail neuron: the role of delayed rectifying K+ currentY H Chen
Department of Nursing, Yuan Pei University of Science and Technology, No 306, Yuan Pei Road, Hsinchu, Taiwan
Neuroscience 138:257-80. 2006The effects of cocaine were studied in an identifiable RP4 neuron of the African snail, Achatina fulica Ferussac, using the two-electrode voltage-clamp method...
- Atrial natriuretic peptide (ANP) in chronic obstructive pulmonary disease (COPD): the relationship between plasma ANP and lung function. Effects of exercise and of the calcium antagonist, isradipine, on plasma ANP. A randomised, double-blind, placebo-contN Graudal
Department of Pulmonary Medicine P/Chest Clinic, Bispebjerg Hospital, Copenhagen, Denmark
Horm Metab Res 24:130-3. 1992..Plasma ANP increases during exercise. The calcium antagonist, isradipine, does not alter resting levels or exercise induced levels of plasma ANP...
- Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cellsE Ashihara
Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
J Cell Physiol 171:343-56. 1997..Therefore, activation of the expression of the Epo receptor gene and activation of the erythroid differentiation program are two independent events in normal hematopoiesis...
- Lovastatin reduces renal vascular reactivity in spontaneously hypertensive ratsJ Jiang
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Hypertens 11:1222-31. 1998....
- Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cellsT Kusama
Molecular Neurobiology, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224
Br J Pharmacol 109:200-6. 1993..Thus,the rho l receptor displayed higher cooperativity.8. Unlike typical GABAA receptors, the rho l receptor was insensitive to the competitive antagonists bicuculline, SR95531, securinine, and (+)-tubocurarine...
- The mcGill-Melzack Pain Questionnaire in the diagnosis of headacheR A Allen
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
Headache 22:20-9. 1982..05) suggesting that the MMPQ is of value in headache diagnosis. Differences between electromyographic studies and headache pain report are discussed as well as suggestions concerning modification of the MMPQ for headache assessment...
- Depressive disorder as possible risk factor of osteoporosisM Vrkljan
Division of Endocrinology, Diabetes and Metabolic Diseases, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Coll Antropol 25:485-92. 2001..01 level (2-tailed). Patients under long-term history of depression could develop a very stronger type of osteoporosis i.e. it is before known that the patients with untreated Cushing syndrome developed hard osteoporosis...
- Measurement of thoracic and lumbar fracture kyphosis: evaluation of intraobserver, interobserver, and technique variabilityT R Kuklo
Orthopaedic Surgery Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
Spine (Phila Pa 1976) 26:61-5; discussion 66. 2001....
- Differentiation between renovascular and essential hypertension by means of changes in single kidney 99mTc-DTPA clearance induced by angiotensin-converting enzyme inhibitionE B Pedersen
Department of Medicine C, Aarhus Kommunehospital, Denmark
Am J Hypertens 2:323-34. 1989....
- Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632P V Rao
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina7710, USA
Invest Ophthalmol Vis Sci 42:1029-37. 2001..Rho kinase, a critical downstream effector of Rho GTPase is recognized to control the formation of actin stress fibers, focal adhesions, and cellular contraction...
- Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosisToshinori Ito
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
Spine (Phila Pa 1976) 32:2070-5. 2007..Immunohistochemical and behavioral study using a rat cauda equina compression model...
- [Effects of fasudil on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma.]Feng Qin Wu
Department of Respiratory Medicine, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
Zhonghua Jie He He Hu Xi Za Zhi 32:847-9. 2009..To explore the role of Rho kinase-1 (ROCK-1) in airway inflammation of asthma by observing the effects of fasudil, a specific inhibitor of ROCK-1, on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma...
- Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 functionJ M Crawford
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710 7599, USA
Dev Biol 204:151-64. 1998..These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning...
- Risk factors for asthma in adult twinsSimon Francis Thomsen
Department of Respiratory Medicine Bispebjerg University Hospital Copenhagen, Denmark
Clin Respir J 1:128-9. 2007..Finally, asthma and posSPT, and rhinitis and posSPT show similar environmental architectures. These results provide new insights into the aetiology of asthma and may be used to guide the choice of traits for genetic linkage analysis...
- Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxinJ T Barbieri
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee 53226, USA
Int J Med Microbiol 290:381-7. 2000..aeruginosa by macrophages. Other studies indicate that Ras plays a role in T cell activation (Cantrell, 1994). Thus, ExoS may inhibit acquired immunity by inhibiting T-cell activation...
- Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding proteinJ A Glaven
Department of Pharmacology, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 271:27374-81. 1996..These findings raise the possibility that in addition to acting directly as a GEF for Rho, Lfc may play other roles that influence the signaling activities of Rac and/or coordinate the activities of the Rac and Rho proteins...
- Sleepiness in different situations measured by the Epworth Sleepiness ScaleM W Johns
Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
Sleep 17:703-10. 1994..The SP in one test situation, including the MSLT, may not be a reliable indicator of a subject's average SP in daily life. Perhaps we should reexamine the current concept of daytime sleepiness and its measurement...
- [Differences in glycemic balance (but not weight) correlate positively with changes in absolute cardiovascular risk in diabetic patients]S Hadjadj
, Centre Hospitalier Universitaire d'Angers
Arch Mal Coeur Vaiss 93:1033-6. 2000..008 and Rho = 0.019; NS, respectively). These results suggest that, in diabetic patients, changes in glycaemic control affect their CRP by an effect on total cholesterol, but the changes in body weight do not affect their CRP...
- Isolation and sequencing of the rho gene from Streptomyces lividans ZX7 and characterization of the RNA-dependent NTPase activity of the overexpressed proteinC J Ingham
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12, United Kingdom
J Biol Chem 271:21803-7. 1996....
- Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized ratAdeleke M Badejo
Department of Pharmacology SL83, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Lung Cell Mol Physiol 295:L828-36. 2008....
- The insensitivity to uncouplers of testis mitochondrial ATPaseM E Vazquez-Memije
Sección de Regulación Metabólica, Unidad de Investigación Biomédica del Centro Médico Nacional, Mexico
Arch Biochem Biophys 260:67-74. 1988..Since testis ATPase is known to be loosely bound to the membrane, an effect of albumin, improving tightness in the interaction of the F1 and the F0 sectors of the ATPase, is suggested...
- Ongoing ultradian activity rhythms in the common vole, Microtus arvalis, during deprivations of food, water and restM P Gerkema
Zoological Laboratory, Groningen University, The Netherlands
J Comp Physiol A 168:591-7. 1991..The onset of the subsequent rest episodes occurred independent of the duration of the preceding alpha'. The duration of rho' was dependent on the preceding, experimental alpha' in a periodic fashion.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Disc degeneration: a human cadaveric study correlating magnetic resonance imaging and quantitative discomanometryE P Southern
Memorial Orthopaedic Surgical Group, Long Beach, California, USA
Spine (Phila Pa 1976) 25:2171-5. 2000..Quantitative discomanometry may be an important technique for evaluating early disc degeneration, especially tears of the anular fibers, which may be missed on magnetic resonance imaging...
- Schwan equation and transmembrane potential induced by alternating electric fieldP Marszalek
Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
Biophys J 58:1053-8. 1990..The good fit of these data to the curves calculated using the Schwan Equation indicates that the equation may be used to describe the transmembrane potential of a living cell generated by an oscillating electric field...
- Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouseMatthew Campbell
Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Ireland
Exp Eye Res 85:714-20. 2007....
- The Rhodobacter sphaeroides 2.4.1 rho gene: expression and genetic analysis of structure and functionM Gomelsky
Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, Texas 77030, USA
J Bacteriol 178:1946-54. 1996..The gene downstream of rho is homologous to thdF, whose product is involved in thiophene and furan oxidation...
- An assessment of the reliability of the ScoliometerG A Murrell
Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina
Spine (Phila Pa 1976) 18:709-12. 1993..998 for the thoracic and lumbar regions, respectively). These results indicate that the Scoliometer can be a reliable noninvasive method for repetitively assessing spinal axial rotation when used by a single trained observer...
- Theoretical study of hydrogen bonding interaction in nitroxyl (HNO) dimer: interrelationship of the two N-H...O blue-shifting hydrogen bondsYing Liu
Key Laboratory of Environmental Optical and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, P R China
J Phys Chem A 110:11760-4. 2006..Ranging from 2.55 to 2.85 A, the cooperative ascending tendencies of the electron densities in two sigma*(N-H) with increasing r(H...O) contribute to the decreases in blue-shift degrees of nu(N-H)...
- Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapyHeba E Abdelmaksoud
Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Exp Eye Res 88:859-79. 2009..Lead hhRz 266 CUC [see in text downward arrow] proved more efficacious than Rz525/hhRz485 which infers viability for rescue of retinal degeneration in appropriate preclinical models of disease...
- The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathwayYasuharu Sasaki
Department of Pharmacology, School of Pharmaceutical Science, Kitasato University, 5 9 1 Shirokane, Minato ku, 108 8641, Tokyo, Japan
Pharmacol Ther 93:225-32. 2002..In this review, we address the possible role of Rho-kinase in neuronal functions, using the Rho-kinase specific inhibitor H-1152P...
- Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibitionDai Yamanouchi
Department of Vascular Surgery, Nagoya University Graduate School of Medical Sciences, Nagoya University, Japan
J Vasc Surg 42:757-64. 2005..We therefore examined the effects of a hydrophilic statin on vein graft intimal hyperplasia in vivo and Rho-kinase activity in vitro...
- Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signalingCarlos Torre
Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94121, USA
Arch Otolaryngol Head Neck Surg 136:493-501. 2010....
- Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constrictionHidemi Kajimoto
Vascular Biology Group, Alberta Cardiovascular and Stroke Research Centre ABACUS, University of Alberta, Edmonton, Canada
Circulation 115:1777-88. 2007..Subsequent membrane depolarization and calcium influx through L-type calcium channels initiates functional closure. We hypothesize that Rho-kinase activation is an additional mechanism that sustains DA constriction...
- Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosisKumi Kitamura
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Gastroenterol Hepatol 22:2022-33. 2007..In this study, the involvement of the Rho/Rho kinase pathway on angiotensin II signaling in liver fibrogenesis and generation of steatosis was investigated...
- Observer variation in assessing spinal curvature and skeletal development in adolescent idiopathic scoliosisM S Goldberg
Department of Epidemiology and Biostatistics, McGill University, , Canada
Spine (Phila Pa 1976) 13:1371-7. 1988..Differences in agreement between surgeons and technicians were relatively minor. These results indicate that personnel trained at this clinic are able to assess these spinal parameters reliably...
- [Abnormal erythrocyte sodium transport in patients with adult polycystic kidney and hypertension]C Guarena
Arch Mal Coeur Vaiss 86:1241-3. 1993....
- Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?James Bellingham
Gene Targeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, United Kingdom
J Exp Zool B Mol Dev Evol 297:1-10. 2003..of rho (which is expressed uniquely in the retina) and the closely related extraretinal rod-like opsin (exo-rhodopsin) gene, errlo (which is expressed uniquely in the pineal), in the puffer-fish, Fugu rubripes (Takifugu rubripes)...
- Expression of Rho GTPases Rho-A and Rac1 in the adult and developing gerbil cerebellumVaea Richard
INSERM U 929, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000 Clermont Ferrand, France
Int J Dev Neurosci 26:723-32. 2008..In addition Rho-A is highly expressed in granule cell progenitor cells present in the external granular layer and therefore may play an important role in granule cell progenitor migration...
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip B Wedegaertner; Fiscal Year: 2013..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
- Akt-regulated pathways in platelet functionDonna S Woulfe; Fiscal Year: 2011..abstract_text> ..
- Development of small molecule Limk inhibitors for probing ocular diseasesPhilip LoGrasso; Fiscal Year: 2012..These compounds will serve as useful molecular tools to study the biological functions of Limk, and to probe ocular diseases and other Limk related CNS diseases. ) ..
- Osteoclastic Protein-Tyrosine Phosphatase and ResorptionKin Hing William Lau; Fiscal Year: 2013..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
- STRUCTURE AND FUNCTION OF PAXILLINChristopher E Turner; Fiscal Year: 2012....
- MECHANISM OF RETROCORNEAL FIBROUS MEMBRANEEunDuck P Kay; Fiscal Year: 2010..Such detailed information is crucial for targeting the specific stage and specific pathway before inflammation causes an irreversible EMT. ..
- Rho Kinase and Airway HyperresponsivenessStephanie A Shore; Fiscal Year: 2013..Thus, the ROCK pathway may be an important and still relatively unexplored therapeutic target in asthma. Understanding the role of ROCKs in mouse models of asthma could lead to new strategies for preventing this disease. ..
- The use of patient-specific iPS cells to identify osteoclast defects in CMDI Ping Chen; Fiscal Year: 2011....
- Lipid Signaling in ChemotaxisMiho Iijima; Fiscal Year: 2013..The long-term goal of our study is to understand how chemotaxis works and how defects in chemotaxis cause human diseases using a variety of approaches including genetics, biochemistry, cell biology and proteomics. ..
- Planar Cell Polarity and the CytoskeletonAndreas Jenny; Fiscal Year: 2013..abstract_text> ..
- The use of patient-specific iPS cells to identify osteoclast defects in CMDI Ping Chen; Fiscal Year: 2013..The long-term goal of this study is to establish CMD as a paradigm for studying mechanisms of rare genetic skeletal disease. ..
- Hypoxia-induced Endothelial Barrier DysfunctionUsamah Kayyali; Fiscal Year: 2009..The findings of this study are expected to further our understanding of mechanisms involved in the development of endothelial barrier dysfunction, in general, and to suggest targets for treatment of pulmonary edema. ..
- Role of p190RhoGEF (Rgnef) in cell motility and tumor progressionNichol L G Miller; Fiscal Year: 2013..The results will enhance our current understanding of intracellular signaling pathways promoting ovarian carcinoma tumor progression. ..
- Fic-mediated AdenylylationCAROLYN ANN WORBY; Fiscal Year: 2013..This covalent addition of AMP blocks signal transduction pathways in the host that are important for combating bacterial infections. ..
- Rho-Modifying Cytotoxic Necrotizing Factor of E. coliALISON DAVIS O'BRIEN; Fiscal Year: 2013..attempt to reduce the extent of inflammation and damage evoked by CP9 through parenteral and/or mucosal immunization of mice with a CNF1/Hly toxoid cocktail. ..
- Novel Signaling Pathways in Ischemic StrokeJAMES KUANG JAN LIAO; Fiscal Year: 2013..This research application proposes to investigate the role of an emerging signaling pathway, Rho kinase (ROCK), in platelets as a potential therapeutic target for preventing and treating ischemic strokes. ..
- Microtubule-associated RacAnna Birukova; Fiscal Year: 2013..These studies will characterize novel barrier protective mechanisms and identify new protein targets for future therapies aimed at prevention of the pulmonary vascular barrier dysfunction associated with acute lung injury. ..
- Control of lung permeability by oxidized phospholipidsKonstantin Birukov; Fiscal Year: 2012....
- The Rho GTPases Cdc42 and Rac1 in diabetic NephropathyJEFFREY BENTON HODGIN; Fiscal Year: 2013....
- CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETIONRichard E Mains; Fiscal Year: 2013....
- Redox Regulation of the rho-GTPases in the vasculatureSharon L Campbell; Fiscal Year: 2012..Thus, information derived from this effort may aid in developing therapies to combat vascular pathologies such as respiratory distress syndrome and ischemia-reperfusion injury. ..
- Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and DifferentiationTHEODOSIA ANASTASIOS KALFA; Fiscal Year: 2012..abstract_text> ..
- Myosin Functions in the EnterocyteMark S Mooseker; Fiscal Year: 2012..g. cystic fibrosis transmembrane conductance regulator, Na+/phosphate exchanger 2b,Toll-like receptor 4) will be explored. ..
- Role of Surface Roughness in Regulating Tumor Cell BehaviorSarah C Glover; Fiscal Year: 2012....
- Functional linkage of NHE1 and calpain in IPAHLarissa A Shimoda; Fiscal Year: 2013..Such information is crucial to advancing treatment and developing new therapeutic options to treat this deadly disease. (End of Abstract) ..
- Vascular Oxidases in MigrationKathy K Griendling; Fiscal Year: 2013..Understanding the mechanisms underlying migration may lead to the development of new therapeutic strategies that can be carefully and specifically targeted to the critically important events in disease initiation. ..
- Protective role of ANP in the models of acute lung injuryAnna Birukova; Fiscal Year: 2013..We believe that these studies may identify novel protein targets and propose new therapies for prevention of pulmonary vascular barrier dysfunction associated with acute lung inflammation and injury. ..
- Nox4 and Vascular Smooth Muscle DifferentiationKathy K Griendling; Fiscal Year: 2013..abstract_text> ..
- Control of Alcohol Responses by Actin-Regulating GenesAdrian Rothenfluh; Fiscal Year: 2013..In conducting this research, we hope to identify risk factors for the development of alcoholism, as well as provide leads for the development of new therapeutic strategies aiding in the treatment of alcohol use disorders. ..
- Cell polarity and agingJOSE RICARDO MCFALINE FIGUEROA; Fiscal Year: 2012..Our studies will provide clues into the conserved mechanisms of cellular and tissue degeneration, and insights into possible treatment strategies. ..
- CDC42GAP in Insulin Signaling in HepatocytesMATTHEW WILLIAM GROGG; Fiscal Year: 2010..Understanding the role of Cdc42GAP and Cdc42 in insulin signaling and glucose homeostasis may allow for modulation of this pathway in the treatment of obesity, diabetes, or cancer. ..
- Developmental Regulation of Collective Cell MigrationDenise J Montell; Fiscal Year: 2013....
- Rho kinase in immune-mediated atherosclerosisWilliam A Boisvert; Fiscal Year: 2010..Successful completion of these studies will likely implicate ROCK in several atherogenic processes and may lead to development of therapies aimed at inhibiting ROCK in macrophages to combat atherosclerosis. ..
- STRUCTURAL ANALYSIS OF G PROTEIN REGULATORY MECHANISMSSTEPHEN SPRANG; Fiscal Year: 2009..The structural models obtained from these results, and the functional hypotheses inferred therefrom will be tested by activity assays of structure- based site directed mutants. ..
- Rho GTPases in Terminal Erythroid MaturationTHEODOSIA ANASTASIOS KALFA; Fiscal Year: 2013..End of Abstract) ..
- Role of alpha6beta4 integrin in epidermal carcinogenesisDavid M Owens; Fiscal Year: 2010....
- Opioid Receptors in Excitatory SynapsesDezhi Liao; Fiscal Year: 2010....
- CALCIUM AND PANCREATIC STIMULUS-SECRETION COUPLINGJohn A Williams; Fiscal Year: 2013..If these enzymes are not inflammatory disease pancreatitis can result. The present work is directed at understanding of the proteins involved in normal digestive enzyme secretion. ..
- Defining the Role of Boi1/Boi2 in the Coordination of Actin Polarity and PolarizeLEAH JOY WATSON; Fiscal Year: 2013..Understanding the basic mechanism involved in cell polarity thus can improve diagnostic and preventative approaches to human disease. ..
- Mechanisms Driving Cortical Cytoskeleton Dynamics in Cancer Cell InvasionKathryn M Eisenmann; Fiscal Year: 2013....
- SIGNALING MECHANISMS IN CELL POLARITY IN YEASTErfei Bi; Fiscal Year: 2012..Deregulation of Cdc42p activity in mammals is associated with serious human diseases, such as cancer. Thus, studying the signaling mechanisms of Cdc42p in yeast will have profound implication in basic biology and clinical sciences. ..
- EPITHELIAL CXCR4 IN A MUCOSAL COMMUNICATION NETWORKMICHAEL DWINELL; Fiscal Year: 2009..abstract_text> ..
- CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODINPETER H MUNDEL; Fiscal Year: 2013..This should in the long-term enable us to develop novel, selective podocyte- protective therapies that tackle proteinuria by promoting the synaptopodin-dependent preservation of the normal foot process architecture. ..
- Role of an unusual GTPase in DNA damage response and carcinogenesisSam W Lee; Fiscal Year: 2012..abstract_text> ..
- Regulation of Microtubules by Rho GTPasesGregg G Gundersen; Fiscal Year: 2013....
- Regulation of Membrane-Cortical Cytoskeleton Crosstalk by WASHSusan M Parkhurst; Fiscal Year: 2013....
- Mechanisms Governing Monocyte Recruitment during Periodontal InflammationRebecca Worthylake; Fiscal Year: 2010..Our studies are designed to understand the molecular mechanisms that govern periodontal inflammation, which will provide necessary information for rational development of therapeutic interventions. ..
- PAK1's role in eotaxin-mediated murine eosinophil migrationMuithi M Mwanthi; Fiscal Year: 2012..We predict that the results in this project will inform the testing of anti-PAK therapy in preventing the development of eosinophilic inflammation in murine models of asthma. ..
- Endothelial Progenitor-derived Endothelial Cells as a Model for Familial CCMChristopher F Dibble; Fiscal Year: 2013..The aims will define regulation of the actin cytoskeleton by the CCM proteins and the ability of therapeutic targeting of the ROCK signaling axis to rescue CCM-related pathophysiology in EP-ECs derived from human patients. ..
- Rap1 - Krit1 Regulation of Endothelial PermeabilityRebecca A Stockton; Fiscal Year: 2012..It will potentially identify target molecules for pharmacological treatment of pathological leak, and genetic treatment of CCM2 disease. (End of Abstract) ..
- BAR proteins linking membrane and cytoskeleton dynamicsRoberto Dominguez; Fiscal Year: 2013..abstract_text> ..
- Small molecule inhibition of Rho GTPase activation to probe signaling cascadesLi An Yeh; Fiscal Year: 2013..These compounds may also serve as potential lead compounds for drug development. ..
- The role of RhoA and its targets in craniofacial cartilage morphogenesisBARBARA SISSON; Fiscal Year: 2010....
- Signaling to Cellular Intercalation in ArabidopsisZhenbiao Yang; Fiscal Year: 2013..Because failure in CE causes neural tube defects, a common developmental disorder (1 out of 1000 pregnancies), this research might ultimately be relevant to human health improvements. ..
- Immune Evasion by Multiple Myeloma: Role of the Rho Kinase Signaling PathwayRandy R Brutkiewicz; Fiscal Year: 2013..Increasing our understanding of the molecular mechanisms that govern antigen presentation by CD1d has applications not only in cancer, but also in infectious diseases, vaccine development and autoimmune diseases. ..
- Rho GTPases and Actin Cytoskeletal Function in Renal IschemiaSimon J Atkinson; Fiscal Year: 2012..The studies proposed will test a possible mechanism leading to cell injury that could be a target for drug therapy. ..
- Stiffness, cadherins, and integrins in mechanochemical signalingChristopher S Chen; Fiscal Year: 2013....
- Structural Biology of Formin ProteinsMichael Eck; Fiscal Year: 2009..Our studies of Bud6 will yield a structure-based model of its function in the establishment of cell polarity, and will provide a paradigm for understanding how diverse formins are engaged for specific cellular functions. ..
- Non-canoical Wnt signaling and cell motilityRaymond Habas; Fiscal Year: 2013..These studies together will advance our knowledge of how non-canonical Wnt signaling regulates cell polarity and cell motility required during gastrulation cell movements and neural fold closure. ..
- Structural Biology of Formin ProteinsMichael J Eck; Fiscal Year: 2013..These studies will reveal both distinct, formin-specific regulatory mechanisms and common principles that are applicable to many formin proteins. ..
- A Toolkit for Light-Control of Molecular Processes in Living CellsORION DAVID WEINER; Fiscal Year: 2013..This highly flexible light-gated protein-protein interaction will provide remote control "dials" that will enable a new generation of perturbative, quantitative experiments in cell biology. ..
- Nox1 and Nox4 Containing Oxidases are Required for PDGF-induced Migration ofHOLLY COLETTE WILLIAMS; Fiscal Year: 2010..Understanding the mechanism by which PDGF induces VSMC migration is very important to developing therapeutic strategies to combat cardiovascular disease. ..
- MOLECULAR MECHANISMS OF PHOTORECEPTOR FUNCTIONBarry E Knox; Fiscal Year: 2010..a. Characterize the UPR/ER stress response in transgenic Xenopus expressing the autosomal dominant rhodopsin mutant, P23H. b. Characterize the UPR/ER stress response in Rho(P23H) transgenic mice...
- A Ribozyme Rescue Strategy for Autosomal Dominant Retinitis PigmentosaJohn M Sullivan; Fiscal Year: 2012..Expected results are knowledge of the minimum amount of WT human rhodopsin that is needed to keep a mammalian rod photoreceptor alive and vital. Aim 3...
- A Ribozyme Rescue Strategy for Dry Age-Related Macular DegenerationJohn M Sullivan; Fiscal Year: 2013..The strategy is: 1) reduce rhodopsin (RHO) to constrain ATR formation that results mostly from rod pigment bleaching, and 2) constrain retinoid cycle ..
- Rhodopsin Trafficking and Retinal DegenerationsAlecia K Gross; Fiscal Year: 2012..The goal of this study is to identify proteins that interact with rhodopsin during transport and those involved in the biogenesis of disk membranes in the outer segment of rod cells, and ..
- Translational Gene Therapy for Rhodopsin Autosomal Dominant Retinitis PigmentosaWilliam A Beltran; Fiscal Year: 2013..animal models (mouse and dog) for translation to patients with autosomal dominant RP caused by mutations in the rhodopsin gene (RHO)...
- Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..A better understanding of factors involved in insulin resistance should enable development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
- MULTIPLEX CIS-REGULATORY ANALYSIS IN MAMMALIAN CELLSJoseph C Corbo; Fiscal Year: 2012..In Aim 1 we will dissect, at single nucleotide resolution, the photoreceptor- specific Rhodopsin (Rho) promoter...
- Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contractionAvril V Somlyo; Fiscal Year: 2012..The results of the research should translate into novel treatments for targeting these diseases. ..
- PLD2, as a GEF or as a Lipase, is Central to Leukocyte ChemotaxisJULIAN G CAMBRONERO; Fiscal Year: 2013..If we can avoid the untimely presence of these cells in ischemia, heart failure after myocardial infarction would then be diminished. ..
- Defining the role and regulation of the RhoGEF Ect2 in ovarian cancer cellsLAUREN PARKER HUFF; Fiscal Year: 2013..If Ect2-dependent transformation is regulated by kinases as I predict, then these kinases may be druggable targets for ovarian cancer. ..
- Development of Vaccines against Clostridium difficile InfectionSAUL R TZIPORI; Fiscal Year: 2013..difficile infection, reduce the severity, or eliminate an ongoing chronic disease. ..
- Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicityTanya N Mayadas; Fiscal Year: 2013..This could lead to the identification of targeted therapeutic strategies that attenuate organ injury while minimally immunocompromising the host. ..
- Neurotrophins in the LungY S Prakash; Fiscal Year: 2012..By establishing the role of neurotrophins in airway narrowing with or without inflammation, the proposed studies will the foundation for better understanding of airway diseases, and potential development of new therapeutic targets. ..
- Regulation of Rho Signaling by S-NitrosothiolsA Richard Whorton; Fiscal Year: 2012..abstract_text> ..
- Diverse Roles for RIC8 During G Protein Signaling in FungiKatherine A Borkovich; Fiscal Year: 2012....
- Cellular and Molecular Regulation of ThrombopoiesisRamesh A Shivdasani; Fiscal Year: 2012..Characterizing key molecular pathways of platelet formation should lead to better control of circulating platelet counts and to implementation of less toxic treatments for cancer. ..
- Functional characterization of Rho inactivation by Vibro cholerae RTX toxinBRETT L GEISSLER; Fiscal Year: 2010..The further characterization of components involved in the regulation of Rho GTPases from the proposed research will also benefit eukaryotic cell signaling research. ..
- Role of Rho Kinase in Aqueous Humor Outflow PathwayP Rao; Fiscal Year: 2004..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
- G Proteins and Endothelial Barrier RegulationTatyana Voyno Yasenetskaya; Fiscal Year: 2004..abstract_text> ..
- Statins and VEGF-induced cytoskeletal remodelingFARHAD DANESH; Fiscal Year: 2009..abstract_text> ..
- GTP-BINDING PROTEIN RHO IN T CELL SIGNALING PATHWAYSJonathan Moorman; Fiscal Year: 2000..Advocates within the Beirne Carter Center for Immunology and the Departments of Medicine and Microbiology will insure that I receive excellent training as I make the transition to an independent investigator. ..
- BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASEBEATRICE YUE; Fiscal Year: 2009..The overall goal of our proposal is to illustrate the mechanisms to provide a deeper understanding regarding the pathogenesis of glaucomas. ..