RhoA

Summary

Gene Symbol: RhoA
Description: ras homolog family member A
Alias: ARH12, ARHA, RHO12, RHOH12, transforming protein RhoA, Aplysia ras-related homolog 12, oncogene RHO H12, small GTP binding protein RhoA
Species: human

Top Publications

  1. pmc Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor
    A Blomquist
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Biochem J 352:319-25. 2000
  2. pmc Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway
    Yi Lai
    Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biol Sci 7:782-91. 2011
  3. pmc The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites
    Wenwu Zhang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 287:33996-4008. 2012
  4. doi Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1
    Simon W Moore
    Centre for Neuronal Survival, Montreal Neurological Institute, Program in NeuroEngineering, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    Development 135:2855-64. 2008
  5. pmc Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, London, England, UK
    J Cell Biol 190:553-63. 2010
  6. ncbi Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    J Y Pillé
    Laboratoire de Recherche MERCI, EA 2122, Faculte de Medecine et Pharmacie, 76183 Rouen, France
    Mol Ther 11:267-74. 2005
  7. pmc PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein
    Yunpeng Bai
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:42316-24. 2011
  8. ncbi Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
    P Billuart
    INSERM U129 ICGM, Faculté de Médecine Cochin, Paris, France
    Nature 392:923-6. 1998
  9. ncbi A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis
    Miguel Vicente-Manzanares
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, C Diego de Leon, 62, E 28006 Madrid, Spain
    J Immunol 168:400-10. 2002
  10. ncbi RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:33492-500. 2003

Research Grants

  1. KATHRYN RENAE WILLIAMS; Fiscal Year: 2014
  2. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2013
  3. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
  4. Adrenergic activation of NHE requires PLD in CCL39 cells
    JOSEPH PROVOST; Fiscal Year: 2006
  5. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013
  6. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
  7. Restoration of Fecal Continence in Aging IAS
    Khalil N Bitar; Fiscal Year: 2012
  8. Neutrophil-dependent regulation of venular permeability
    Sarah Y Yuan; Fiscal Year: 2011
  9. BARRY S KREUTZ; Fiscal Year: 2014
  10. Kenneth A Jacobson; Fiscal Year: 2015

Detail Information

Publications290 found, 100 shown here

  1. pmc Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor
    A Blomquist
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Biochem J 352:319-25. 2000
    ..p114-Rho-GEF interacted specifically with RhoA, in its nucleotide-free and guanosine 5'-[gamma-thio]triphosphate-bound states, but not with Rac1 and Cdc42, and ..
  2. pmc Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway
    Yi Lai
    Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biol Sci 7:782-91. 2011
    ..These processes required parallel upregulation of the small GTPases Rac1 and RhoA. Moreover, we demonstrated that IL-8 activated PI3K following the same kinetics observed from IL-8 induction of ..
  3. pmc The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites
    Wenwu Zhang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 287:33996-4008. 2012
    The activation of the small GTPase RhoA is necessary for ACh-induced actin polymerization and airway smooth muscle (ASM) contraction, but the mechanism by which it regulates these events is unknown...
  4. doi Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1
    Simon W Moore
    Centre for Neuronal Survival, Montreal Neurological Institute, Program in NeuroEngineering, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    Development 135:2855-64. 2008
    ..Activation of the RhoA subfamily of Rho GTPases is essential for chemorepellent axon guidance; however, their role during axonal ..
  5. pmc Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, London, England, UK
    J Cell Biol 190:553-63. 2010
    ..this study, we use an RNA interference screen to identify which Rho GTPases affect T cell TEM and demonstrate that RhoA is critical for this process...
  6. ncbi Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    J Y Pillé
    Laboratoire de Recherche MERCI, EA 2122, Faculte de Medecine et Pharmacie, 76183 Rouen, France
    Mol Ther 11:267-74. 2005
    Overexpression of RhoA or RhoC in breast cancer indicates a poor prognosis, due to increased tumor cell proliferation and invasion and tumor-dependent angiogenesis...
  7. pmc PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein
    Yunpeng Bai
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:42316-24. 2011
    ..Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2 and RhoA pathways, the mechanism by which it activates these signaling events remains unclear...
  8. ncbi Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
    P Billuart
    INSERM U129 ICGM, Faculté de Médecine Cochin, Paris, France
    Nature 392:923-6. 1998
    ..Such activation is known to affect cell migration and outgrowth of axons and dendrites in vivo. Our results demonstrate an association between cognitive impairment and a defect in a signalling pathway that depends on a Ras-like GTPase...
  9. ncbi A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis
    Miguel Vicente-Manzanares
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, C Diego de Leon, 62, E 28006 Madrid, Spain
    J Immunol 168:400-10. 2002
    ..SDF-1alpha induced activation of RhoA, but not that of Rac...
  10. ncbi RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:33492-500. 2003
    We tested the hypothesis that RhoA, a monomeric GTP-binding protein, induces association of inositol trisphosphate receptor (IP3R) with transient receptor potential channel (TRPC1), and thereby activates store depletion-induced Ca2+ entry ..
  11. doi Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway
    Micha Nethe
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 123:1948-58. 2010
    ..The actin cytoskeleton is regulated through signalling by Rho-like GTPases, such as RhoA, which stimulates myosin-based contractility, and CDC42 and Rac1, which promote actin polymerization and protrusion...
  12. doi Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
    Mariola J Edelmann
    Department of Clinical Medicine, University of Oxford, Oxford, UK
    FEBS J 277:2515-30. 2010
    ..OTUB1, YpkA and the small GTPase ras homologue gene family member A (RhoA) were found to be part of the same protein complex, suggesting that RhoA levels are modulated by OTUB1...
  13. ncbi Lysophosphatidic acid stimulates PC-3 prostate cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity
    Young Sun Hwang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Carcinog 45:518-29. 2006
    ..was performed to determine the relationship of lysophosphatidic acid (LPA) stimulation and increased Ras homolog A (RhoA) activity to nuclear factor kappa B (NF-kappaB) activity, and the role of these factors in regulating prostate ..
  14. pmc Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension
    Kiran Bhadriraju
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Cell Res 313:3616-23. 2007
    ..that adhesion and the associated changes in cell shape and cytoskeletal tension are all required for GTP-bound RhoA to activate its downstream effector, ROCK...
  15. pmc The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    T Leung
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Mol Cell Biol 16:5313-27. 1996
    The GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, motility, and cytokinesis...
  16. ncbi MgF(3)(-) as a transition state analog of phosphoryl transfer
    Debbie L Graham
    Computational and Structural Sciences, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, United Kingdom
    Chem Biol 9:375-81. 2002
    ..We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+)...
  17. ncbi Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells
    Katsuya Ando
    Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan
    J Atheroscler Thromb 18:762-73. 2011
    ..factor (TF) and plasminogen activator inhibitor-1 (PAI-1) protein expression, which is modulated by small GTPases RhoA and Rac1, Ca(2+) signaling and reactive oxygen species (ROS)...
  18. ncbi Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution
    Kenton Longenecker
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Acta Crystallogr D Biol Crystallogr 59:876-80. 2003
    Mutants of the small G protein RhoA that are deficient in GTPase activity and thereby exhibit constitutive molecular signaling activity are commonly used to discover its cellular functions...
  19. ncbi Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling
    Ferran Valderrama
    Cell Motility Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, WC2A 3PX London, UK
    Science 311:377-81. 2006
    b>RhoA signaling plays a critical role in many cellular processes, including cell migration...
  20. ncbi ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA
    Julien Laboureau
    Institut de Recherche sur la Peau, Hopital Saint Louis, Paris, France
    Exp Dermatol 13:70-7. 2004
    ..Transfection with C3 transferase, known to inhibit rhoA, and inhibition of rock (a downstream effector of rhoA), gave similar results...
  21. ncbi Roles of Rho guanosine 5'-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast
    Catalin Nicola
    Department of Anatomy, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Endocrinology 149:1243-51. 2008
    ..b>RhoA GTPase and its important effector Rho kinase (ROCK) have also been previously shown to regulate trophoblast ..
  22. pmc RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1
    Carmen Garnacho
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6068, USA
    Blood 111:3024-33. 2008
    ..we found that the PECAM-1 cytoplasmic domain and, more precisely, PECAM-1 tyrosine 686, is critical in mediating RhoA activation and recruitment of EGFP-RhoA to anti-PECAM/NC binding sites at the plasmalemma, actin polymerization ..
  23. pmc Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity
    Heather S Carr
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Biol Chem 284:24269-80. 2009
    Net1 is a nuclear Rho guanine nucleotide exchange factor that is specific for the RhoA subfamily of small G proteins...
  24. pmc Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes
    Cristina Has
    Department of Dermatology, University Medical Center Freiburg, Freiburg 79104, Germany
    Am J Pathol 175:1442-52. 2009
    ..processes by signaling via Rho family GTPases, and it is required to maintain the pool of GTP-bound, active Rac1, RhoA and Cdc42, and the phosphorylation of their downstream effectors p21-activated kinase 1, LIM kinase, and cofilin...
  25. pmc OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling
    Sungwoo Ryoo
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 4904, United States
    Atherosclerosis 214:279-87. 2011
    ..We tested the hypotheses that OxLDL-dependent arginase II activation occurs through a specific receptor, and via a Rho GTPase effector mechanism that is inhibited by statins...
  26. ncbi Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
    R Habas
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 107:843-54. 2001
    ..Our study illustrates a molecular pathway from Wnt/Fz signaling to Rho activation in cell polarity signal transduction...
  27. pmc GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA
    Yuan Chen Chang
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2147-53. 2008
    The RhoA GTPase plays a vital role in assembly of contractile actin-myosin filaments (stress fibers) and of associated focal adhesion complexes of adherent monolayer cells in culture...
  28. ncbi Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progressio
    Lilly Y W Bourguignon
    Department of Medicine, University of California at San Francisco and the Endocrine Unit 111N, Veterans Affairs Medical Center, San Francisco, Calfornia 94121, USA
    J Biol Chem 278:29420-34. 2003
    In this study we have examined CD44 (a hyaluronan (HA) receptor) interaction with a RhoA-specific guanine nucleotide exchange factor (p115RhoGEF) in human metastatic breast tumor cells (MDA-MB-231 cell line)...
  29. pmc Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling
    Naoto Kakinuma
    Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    J Cell Biol 181:537-49. 2008
    ..Furthermore, Kank inhibits insulin and active Akt-dependent activation of RhoA through binding to 14-3-3...
  30. ncbi RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion
    Irina Abécassis
    INSERM U496, Hopital Saint Louis, 1 Ave C Vellefaux, 75010, Paris, France
    Exp Cell Res 291:363-76. 2003
    ..Here we report that small RhoA GTPase is implicated in the invasion of human microvascular endothelial cells (HMEC-1)...
  31. ncbi Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
    M Symons
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Cell 84:723-34. 1996
    ..The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization...
  32. ncbi Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling
    E Klussmann
    Forschungsinstitut fur Molekulare Pharmakologie, Campus Berlin Buch, Berlin, Germany
    FEBS Lett 507:264-8. 2001
    ..The Ht31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP/GTP exchange factor proto-lymphoid blast crisis (Lbc) sequences...
  33. ncbi Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    Estela Jacinto
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 6:1122-8. 2004
    ..mTORC2 is not upstream of the mTORC1 effector S6K. Thus, two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth...
  34. pmc Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27
    Melissa C Garcia
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:20936-45. 2009
    ..Here we report that in MDA-MB-435 human melanoma cells, arachidonic acid activates RhoA, and inhibition of RhoA signaling with either C3 exoenzyme or dominant negative Rho blocked arachidonic acid-..
  35. pmc p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
    N Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo, Japan
    EMBO J 16:3044-56. 1997
    ..p140mDia binds selectively to the GTP-bound form of Rho and also binds to profilin. p140mDia, profilin and RhoA are co-localized in the spreading lamellae of cultured fibroblasts...
  36. ncbi Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells
    Xianwu Li
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:15309-16. 2002
    Geranylgeranylation of RhoA small G-protein is essential for its localization to cell membranes and for its biological functions. Many RhoA effects are mediated by its downstream effector RhoA kinase...
  37. pmc Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA
    Violaine Moreau
    Institut Européen de Chimie Biologie, INSERM U441, 33600 Pessac, France
    Mol Cell Biol 23:6809-22. 2003
    ..These data provide the first description of podosomes in endothelial cells. The identification of such specialized structures opens up a new field of investigation in terms of endothelium pathophysiology...
  38. ncbi Regulation of PTEN by Rho small GTPases
    Zhong Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Cell Biol 7:399-404. 2005
    ..However, the mechanisms for its regulation remain elusive. Here we show that RhoA and Cdc42, members of the Rho family of small GTPases, regulate the intracellular localization of PTEN in ..
  39. pmc Inhibition of Rho A activity causes pemphigus skin blistering
    Jens Waschke
    Institute of Anatomy and Cell Biology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Cell Biol 175:721-7. 2006
    ..This may open the possibility of pemphigus treatment with the epidermal application of Rho A agonists...
  40. ncbi Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
    Susanne Lutz
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Maybachstrasse 14, D 68169 Mannheim, Germany
    Science 318:1923-7. 2007
    ..and thereby links Galphaq-coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA. We determined the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq ..
  41. pmc RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
    MICHELLE D LARREA
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:9268-73. 2009
    ..We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility. RSK1 activation and p27pT198 both increase in early G(1)...
  42. pmc Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation
    Keiichiro Okuhira
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8511, Japan
    J Biol Chem 285:16369-77. 2010
    ..LARG bind to the C terminus of ABCA1 by a PDZ-PDZ interaction and prevent ABCA1 protein degradation by activating RhoA. ABCA1 is a protein with a short half-life, and apoA-I stabilizes ABCA1 protein; however, depletion of PDZ-RhoGEF/..
  43. ncbi Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
    Kaylene J Simpson
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston Massachusetts 02215, USA
    Cancer Res 64:8694-701. 2004
    Although the RhoA and RhoC proteins comprise an important subset of the Rho GTPase family that have been implicated in invasive breast carcinomas, attributing specific functions to these individual members has been difficult...
  44. ncbi RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9
    Ronit Pasvolsky
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 180:2815-23. 2008
    ..The GTPase RhoA was previously implicated in CCL21-triggered LFA-1 affinity triggering in murine T lymphocytes and in LFA-1-..
  45. ncbi Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation
    K Missy
    Institut Fédératif de Recherche en Immunologie Cellulaire et Moléculaire, Université Paul Sabatier and Centre Hospitalo Universitaire de Toulouse, Inserm Unite 326, France
    J Biol Chem 273:30279-86. 1998
    ..reports suggest that under different conditions leading to cytoskeleton reorganization the GTPase Rac1 and possibly RhoA are downstream targets of phosphoinositide 3-kinase (PI 3-kinase)...
  46. ncbi RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear
    Simone M Schoenwaelder
    Department of Medicine, Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Arnold St, Box Hill, Victoria 3128, Australia
    J Biol Chem 277:14738-46. 2002
    The small GTPase RhoA modulates the adhesive nature of many cell types; however, despite high levels of expression in platelets, there is currently limited evidence for an important role for this small GTPase in regulating platelet ..
  47. ncbi Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics
    Thierry Dubois
    Membrane and Cytoskeleton Dynamics Group, Institut Curie, CNRS UMR144, 75248 Paris, France
    Nat Cell Biol 7:353-64. 2005
    ..Our results establish a role for ARHGAP10 in Golgi structure and function at the crossroads between ARF1 and Cdc42 signalling pathways...
  48. pmc MAGI-3 regulates LPA-induced activation of Erk and RhoA
    Huanchun Zhang
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 19:261-8. 2007
    ..Previous studies have shown that the cellular signaling elicited by LPA results in activation of the small GTPase RhoA by Galpha(12/13) - as well as Galpha(q)-dependent pathways...
  49. ncbi RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65
    Khandaker N Anwar
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Immunol 173:6965-72. 2004
    We investigated the involvement of the RhoA/Rho-associated kinase (ROCK) pathway in regulating ICAM-1 expression in endothelial cells by the procoagulant, thrombin...
  50. ncbi Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue
    K Ihara
    Divisions of Structural Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 01, Japan
    J Biol Chem 273:9656-66. 1998
    The 2.4-A resolution crystal structure of a dominantly active form of the small guanosine triphosphatase (GTPase) RhoA, RhoAV14, complexed with the nonhydrolyzable GTP analogue, guanosine 5'-3-O-(thio)triphosphate (GTPgammaS), reveals a ..
  51. ncbi The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly
    P Matarrese
    Department of Ultrastructures, Instituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Cell Death Differ 7:25-36. 2000
    ..e. by inducing anoikis-resistance. These particular effects of vpr might enhance the homing, spreading and survival of the infected lymphocytes, thus contributing to virus persistence in the course of acute HIV-1 infection...
  52. ncbi The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element
    C Reynaud
    Laboratoire de Biologie Moleculaire et Cellulaire, Unité Mixte de Recherche 5665, CNRS Ecole Normale Supérieure de Lyon, 46, Allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 275:33962-8. 2000
    ..including the c-Fos serum response element (SRE) showed that coexpression of TIP-1 with the constitutively active RhoA.V14 mutant and human rhotekin caused a strong activation of the SRE. A negative mutant of Rho, RhoA...
  53. ncbi IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription
    Ling Yu Chen
    Department of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:3934-9. 2002
    ..Stimulation of monocytes with LPS rapidly activated RhoA, and pretreatment of monocytes with a RhoA inhibitor, C3 transferase exoenzyme, effectively blocked LPS-induced IL-..
  54. ncbi alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells
    Chiara Urbinati
    General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europe 11, 25123 Brescia, Italy
    J Cell Sci 118:3949-58. 2005
    ..Also, alpha(v)beta(3)/Tat interaction triggers the activation of focal adhesion kinase, RhoA and pp60src...
  55. ncbi Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner
    Fumihiko Niiya
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892 4256, USA
    J Biol Chem 280:36502-9. 2005
    Cleavage furrow formation marks the onset of cell division during early anaphase. The small GTPase RhoA and its regulators ECT2 and MgcRacGAP have been implicated in furrow ingression in mammalian cells, but the signaling upstream of ..
  56. pmc Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
    Mark E Burkard
    Molecular Biology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:4383-8. 2007
    ..of both Plk1 itself and the Rho guanine nucleotide exchange factor (RhoGEF) Ect2 to the central spindle, abolishes RhoA GTPase localization to the equatorial cortex, and suppresses cleavage furrow formation and cell division...
  57. ncbi Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo
    Tadanori Mammoto
    Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology and Center for Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 282:23910-8. 2007
    ..This induces activation of one endogenous GTPase, Rac1, and inhibition of another, RhoA. Loss of either part of this dual effect abrogates the cytoskeletal and anti-permeability actions of Ang-1, ..
  58. pmc GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability
    Nebojsa Knezevic
    Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Mol Cell Biol 27:6323-33. 2007
    We identified the GDI-1-regulated mechanism of RhoA activation from the Rho-GDI-1 complex and its role in mediating increased endothelial permeability...
  59. ncbi The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin
    Yoshiki Arakawa
    Cell Motility Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cell Host Microbe 1:227-40. 2007
    ..and the subsequent release of virus particles, which are both actin dependent, require F11L-mediated inhibition of RhoA-mDia signaling...
  60. doi Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma
    Tatsuya Orimo
    Proteome Bioinformatics Project, National Cancer Center Hospital, Tokyo, Japan
    Hepatology 48:1851-63. 2008
    ..which 14 were functionally linked to c-Myc, AP-1, HIF1A, hepatocyte nuclear factor 4 alpha, or the Ras superfamily (RhoA, CDC42, and Rac1)...
  61. ncbi Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins
    G M Bokoch
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 269:31674-9. 1994
    ....
  62. pmc Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    T Matsui
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
    EMBO J 15:2208-16. 1996
    ..This protein bound to GTPgammaS (a non-hydrolyzable GTP analog).RhoA but not to GDP.RhoA or GTPgammaS.RhoA with a mutation in the effector domain (RhoAA37)...
  63. pmc RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
    C N Adra
    Harvard Institutes of Medicine, HIM955, Beth Israel Hospital, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:4279-84. 1997
    ..It binds to CDC42 and RhoA with less affinity compared with RhoGDI and does not bind with Rac1, Rac2, or Ras...
  64. ncbi Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum
    Q Dai
    Departments of Medicine and Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 273:15030-4. 1998
    ..Thus, the final enzyme in the sequence that modifies CAAX motifs is located in membranes topologically removed from the CAAX protein target membrane...
  65. ncbi The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain
    Q G Medley
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 275:36116-23. 2000
    ..Herein we provide evidence that Trio not only activates RhoA but is also a RhoA target. The RhoA-binding site was mapped to the Trio immunoglobulin-like domain...
  66. pmc Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
    D Michaelson
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Cell Biol 152:111-26. 2001
    ..Targeting was regulated by binding to RhoGDI alpha in the case of RhoA, Rac1, Rac2, and Cdc42hs but not RhoB or TC10...
  67. ncbi Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
    Jason T Snyder
    Department of Biochemistry and Biophysics, Program in Molecular and Cellular Biophysics, Chapel Hill, North Carolina 27599, USA
    Nat Struct Biol 9:468-75. 2002
    ..homology domains) of the exchange factors intersectin and Dbs in complex with their cognate GTPases, Cdc42 and RhoA, respectively...
  68. ncbi The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization
    Jeremy W Peck
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    J Biol Chem 277:43924-32. 2002
    ..Here we have identified a ubiquitously expressed human RhoA-binding protein, designated Rhophilin-2...
  69. ncbi Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway
    Ioulia Kiian
    Nephrology Department, Hannover Medical School, Carl Neuberg Strasse I, 30625 Hannover, Germany
    Thromb Haemost 89:904-14. 2003
    ..We report that active GTP-bound forms of small GTPases RhoA and Rac1, but not Cdc42, are directly associated with Tyk2 and PI3-K in an uPA/uPAR-dependent fashion...
  70. pmc RhoE binds to ROCK I and inhibits downstream signaling
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom
    Mol Cell Biol 23:4219-29. 2003
    ..RhoE induces stress fiber disassembly in a variety of cell types, whereas RhoA stimulates stress fiber assembly...
  71. ncbi Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
    Akiko Horiuchi
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan
    Lab Invest 83:861-70. 2003
    ..role of small GTPases Rho in the biologic behavior of ovarian carcinoma, we first examined the mRNA expression of RhoA, RhoB, and RhoC in benign, borderline, and malignant ovarian tumors using RT-PCR and real-time RT-PCR...
  72. ncbi Rnd proteins function as RhoA antagonists by activating p190 RhoGAP
    Krister Wennerberg
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 13:1106-15. 2003
    ..suggested that Rnd proteins play pivotal roles in cell regulation by counteracting the biological functions of the RhoA GTPase, but the molecular basis for this antagonism is unknown...
  73. ncbi Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity
    Na Liu
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, Peoples Republic of China
    Clin Cancer Res 10:6239-47. 2004
    The small GTPase RhoA has been implicated in the regulation of cell morphology, motility, and transformation, but the role of RhoA protein in the carcinogenesis of gastric cancer remains unclear...
  74. ncbi Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux
    Carmen A Argmann
    Robarts Research Institute, Vascular Biology Group, and the Departments of Medicine and Biochemistry, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Biol Chem 280:22212-21. 2005
    ..demonstrated to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through enhanced RhoA geranylgeranylation...
  75. ncbi Serine phosphorylation differentially affects RhoA binding to effectors: implications to NGF-induced neurite outgrowth
    Nora Nusser
    Department of Physiology, University of Tennessee Health Science Center, Memphis, 894 Union Ave, Memphis, TN 38163, USA
    Cell Signal 18:704-14. 2006
    Activation of RhoA prevents NGF-induced outgrowth and causes retraction of neurites in neuronal cells, including PC12 cells...
  76. ncbi Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38
    Ute Dreissigacker
    Department of Pharmacology and Toxicology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Cell Signal 18:1156-68. 2006
    ..Stable expression of EGFP-K-Ras (V12) down-regulated the activity of Rac1 and RhoA, resulting in reduced subcortical actin filaments and stress fibers, which might contribute to the epithelial ..
  77. pmc Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism
    Kit Wong
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 2140, USA
    Proc Natl Acad Sci U S A 103:3639-44. 2006
    ..b>RhoA and its downstream effector, myosin II, mediate the "backness" response, which locally inhibits the "frontness" ..
  78. ncbi Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility
    John R Basile
    Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:34888-95. 2007
    ..and dominant negative and pharmacological inhibitors that this response is dependent upon the activation of RhoA and its downstream target, Rho kinase (ROK)...
  79. doi Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis
    Dag Daniel Dittert
    Department of Pathology, University Hospital Carl Gustav Carus, D 01307 Dresden, Germany
    Hum Pathol 39:1002-10. 2008
    ..b>RhoA belongs to a family of ras homologues comprising RhoA, RhoB, and RhoC...
  80. doi RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha
    T T Giang Ho
    Laboratory of Connective Tissues Biology, GIGA R, University of Liege, Tour de Pathologie, Sart Tilman, Belgium
    J Biol Chem 283:21588-98. 2008
    b>RhoA plays a significant role in actin stress fibers formation. However, silencing RhoA alone or RhoA and RhoC did not completely suppress the stress fibers suggesting a residual "Rho-like" activity...
  81. doi RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors
    Siyuan Zhang
    Sichuan University, Chengdu 610041, Sichuan Province, People s Republic of China
    Mol Cancer Res 7:570-80. 2009
    b>RhoA, a member of the Rho GTPase family, has been extensively studied in the regulation of cytoskeletal dynamics, gene transcription, cell cycle progression, and cell transformation...
  82. pmc RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Blood 114:619-29. 2009
    ..In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis of MM...
  83. doi LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
    Koichi Sugimoto
    First Department of Internal Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Cardiovasc Res 84:127-36. 2009
    b>RhoA and Rac1 activation plays a key role in endothelial dysfunction. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells (ECs)...
  84. doi Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts
    Jessica L Johnson
    Department of Biology, University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 122:2263-73. 2009
    ..Instead, the loss of CD151 causes excessive RhoA activation, loss of actin organization at cell-cell junctions, and increased actin stress fibers at the basal cell ..
  85. pmc Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex
    Jakub M Swiercz
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D 69120 Heidelberg, Germany
    Mol Cell Biol 29:6321-34. 2009
    ..interacts with particular Rho guanine nucleotide exchange factors (RhoGEFs) and thereby mediates Sema4D-induced RhoA activation, a process which involves the tyrosine phosphorylation of plexin-B1 by ErbB-2...
  86. pmc Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif
    Amir Aghajanian
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e8045. 2009
    ..We hypothesized that this redox-based mechanism occurs in cells and affects cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA.
  87. pmc Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA
    Lisa M Godsel
    Northwestern University Feinberg School of Medicine, Department of Pathology, Chicago, IL 60611, USA
    Mol Biol Cell 21:2844-59. 2010
    ..Our data suggest that these defects result from the failure of activated RhoA to localize at intercellular interfaces after cell-cell contact and an elevation of cellular RhoA, stress fibers, ..
  88. pmc The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation
    Michael D Bear
    Division of Pulmonary and Critical Care, Tupper Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 285:32919-26. 2010
    ..b>RhoA/Rho kinase (ROCK) function is required for 5-HT-induced PASMC mitogenesis, and 5-HT activates RhoA; however, the ..
  89. doi RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration
    Matthieu Rousseau
    Inserm UMR U892, Centre de Recherche en Cancérologie Nantes Angers CRCNA, Institut de Recherche Thérapeutique IRT UN, Universite de Nantes, 8 quai Moncousu, BP 70721, F 44007, France
    Biochem Biophys Res Commun 414:750-5. 2011
    ..Small GTPase RhoA and its effector ROCK are crucial signaling molecules involved in many endothelial cellular functions...
  90. pmc Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation
    KATHLEEN L O'CONNOR
    Markey Cancer Center, Lexington, KY 40506 0509, USA
    Am J Physiol Cell Physiol 302:C605-14. 2012
    ..RhoC for motility, whereas integrin α(6)β(4)-expressing cells utilize RhoC but additionally activate and utilize RhoA for LPA-dependent cell motility and lamellae formation...
  91. pmc Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins
    Frank Medina
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 288:11325-33. 2013
    ..A direct mechanism for hormonal regulation of the RhoA-type GTPases is their modulation by the G12 and G13 proteins via RH (RGS homology) containing RhoGEFs...
  92. pmc A novel role for RhoGDI as an inhibitor of GAP proteins
    J F Hancock
    Onyx Pharmaceuticals, Richmond, CA 94806
    EMBO J 12:1915-21. 1993
    ..with RhoGDI and that, whilst geranylgeranylation and -AAX proteolysis of the C-terminal CAAX motif of Rac1 and RhoA are required for efficient interaction with RhoGDI, methylesterification of the C-terminal cysteine residue is not ..
  93. ncbi A novel partner for the GTP-bound forms of rho and rac
    P Madaule
    Second Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    FEBS Lett 377:243-8. 1995
    ..We recently identified three others putative rho effectors characterized by a common rho binding motif. Citron does not share this motif and displays a distinctive protein organization, thus defining a separate class of rho partners...
  94. ncbi Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
    T Reid
    Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 271:13556-60. 1996
    ..One clone obtained by this procedure contained a novel cDNA of 291 base pairs and interacted strongly with RhoA and RhoC, weakly with RhoB, and not at all with Rac1 and Cdc42Hs...
  95. pmc The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization
    S Vincent
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    Mol Cell Biol 17:2247-56. 1997
    ..Activated RhoA has recently been reported to interact directly with several protein kinases, p120 PKN, p150 ROK alpha and -beta, ..
  96. ncbi Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity
    J P Gorvel
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    FEBS Lett 422:269-73. 1998
    b>RhoA/B/C and CDC42/Rac, which form two subgroups of the rho guanosine triphosphatase (GTPase) family, regulate various aspects of actin cytoskeleton organisation...
  97. ncbi Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    Biochemistry 37:5249-57. 1998
    The small GTP-binding protein RhoA becomes inactivated by hydrolyzing bound GTP to GDP through its intrinsic GTPase activity which is further stimulated by a family of Rho GTPase-activating proteins (GAPs)...
  98. ncbi Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    M Maekawa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8315, Japan
    Science 285:895-8. 1999
    ..These results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylation of cofilin by LIM-kinase contribute to Rho-induced reorganization of the actin cytoskeleton...
  99. ncbi Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member
    U Rümenapp
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, D 45122, Essen, Germany
    FEBS Lett 459:313-8. 1999
    ..an amino-terminal PDZ domain and a regulator of G protein signalling (RGS) homology domain, is a specific GEF for RhoA, but not for Rac1 and Cdc42, as determined by GDP release, guanosine 5'-O-(3-thio)triphosphate (GTPgammaS) binding ..
  100. ncbi The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1
    R Maesaki
    Division of Structural Biology, Nara Institute of Science and Technology, Japan
    Mol Cell 4:793-803. 1999
    ..Here we report the 2.2 A crystal structure of RhoA bound to an effector domain of protein kinase PKN/PRK1...
  101. ncbi RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription
    C Allal
    Oncologie Cellulaire et Moléculaire, EA 2048 Université Paul Sabatier, Centre de Lutte Contre le Cancer Claudius Regaud, 20 24 rue du Pont saint Pierre, 31052 Toulouse Cedex, France
    J Biol Chem 275:31001-8. 2000
    The importance of post-translational geranylgeranylation of the GTPase RhoA for its ability to induce cellular proliferation and malignant transformation is not well understood...

Research Grants80

  1. KATHRYN RENAE WILLIAMS; Fiscal Year: 2014
    ..The small GTPase, RhoA, a well-characterized regulator of actin dynamics, has been suggested to play a critical role in regulating the ..
  2. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2013
    ..effects of HGAL on myosin II function;2) Determine effects of HGAL on a member of the small Rho GTPase family - RhoA protein and its effectors;3) Determine the role of HGAL myristoylation and palmytoylation on its inhibitory effects ..
  3. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
    ..In this regard Rho proteins are particularly important. For example RhoA signaling through Rho-kinases regulate diverse vascular functions including smooth muscle contraction and migration,..
  4. Adrenergic activation of NHE requires PLD in CCL39 cells
    JOSEPH PROVOST; Fiscal Year: 2006
    ..Two PLD isoforms have been identified based upon their specificity for activators. PLD1 is activated by RhoA, protein kinase C (PKC), and Arf, while PLD2 has a substantial basal level of activity but may be regulated by Arf ..
  5. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013
    ..Rho GTPases, such as RhoA, are molecular switches that act to control cell adhesion, motility and have been implicated in tumor progression...
  6. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..We will also measure RhoA and RhoGEFs, molecules upstream in the ROCK signaling pathway, as well as phosphorylation of MBS, CPI-17, and Ef1a, ..
  7. Restoration of Fecal Continence in Aging IAS
    Khalil N Bitar; Fiscal Year: 2012
    ..results from Human IAS and Human circular colonic smooth muscle cells (CSMC) indicate: 1) Sequestration of RhoA, phospho-PKC[unreadable] (S657) and HSP27 only in the caveolin-rich lipid raft microdomains of IAS cells at rest ..
  8. Neutrophil-dependent regulation of venular permeability
    Sarah Y Yuan; Fiscal Year: 2011
    ..and MLC phosphorylation via p60Src-activation of endothelial-specific myosin light chain kinase (eMLCK) and RhoA-inhibition of the myosin targeting subunit of myosin light chain phosphatase (MLCP)...
  9. BARRY S KREUTZ; Fiscal Year: 2014
    ..family of heterotrimeric G proteins, which consists of G12 and G13, has been shown to mediate signals from GPCRs to RhoA activation...
  10. Kenneth A Jacobson; Fiscal Year: 2015
    ..initial models will be developed to test our hypothesis that oscillations occur as a result of a traveling wave of RhoA activity...
  11. Magdalena Chrzanowska; Fiscal Year: 2016
    ..in the absence of Rap1 isoforms, VEGF-induced signaling converging at VE-cadherin and differential regulation of RhoA by Rap1 in response to VEGF and Epac activation will be examined in ECs isolated from Rap1-deficient mice...
  12. David D Schlaepfer; Fiscal Year: 2016
    ..We also created an Rgnef knockout mouse and analyses of Rgnef-/- fibroblasts established the importance of Rgnef in RhoA regulation, focal adhesion formation, and cell migration downstream of integrins...
  13. Keith Burridge; Fiscal Year: 2016
    ..The goal of the first aim is to determine how adhesion to the extracellular matrix protein fibronectin stimulates RhoA. Having recently identified guanine nucleotide exchange factors, such as Lsc, that are involved in this process, we ..
  14. Defining the role and regulation of the RhoGEF Ect2 in ovarian cancer cells
    LAUREN PARKER HUFF; Fiscal Year: 2013
    ..Rho GTPases act as signaling nodes to regulate many properties important for cancer phenotypes, and several (RhoA/C, Rac1, Cdc42) are overactive in ovarian cancer...
  15. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..it also induces morphological changes in endothelial cells (EC) and tumor cells characterized by inactivation of RhoA, loss of stress fibers, collapse of the F-actin cytoskeleton and inhibition of migration...
  16. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..We demonstrated that the Fic domains of IbpA induce cytotoxicity by targeting the host GTPases, RhoA, Rac and Cdc42...
  17. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..factor type 1 (CNF1) is a member of a family of bacterial toxins that deamidate single glutamine residues in RhoA, Rac, and Cdc42 and thereby constitutively activate these small GTPases...
  18. Fabeha Fazal; Fiscal Year: 2014
    ..We previously showed that activation of RhoA/ROCK and the dynamic changes in actin cytoskeleton induced by thrombin are crucial for NF-(B activation and ICAM-1 ..
  19. Redox Regulation of RhoA and Modulation of Vascular Permeability
    Amir Aghajanian; Fiscal Year: 2012
    ..In endothelial cells, the small GTPase RhoA plays a key role in the regulation of vascular permeability through modulation of the actin cytoskeleton and cell-..
  20. Yingxiao Wang; Fiscal Year: 2014
    ..We hypothesized that different flows can induce a RhoA/actin-dependent activation of Src with distinct spatiotemporal patterns...
  21. Redox Regulation of the rho-GTPases in the vasculature
    Sharon L Campbell; Fiscal Year: 2012
    ..We have previously demonstrated that a subset of Rho GTPases, i.e., Rac1, RhoA and Cdc42, contain a thiol in the guanine nucleotide binding site that reacts with reactive oxygen and nitrogen ..
  22. Diane S Krause; Fiscal Year: 2016
    ..GEF-H1 and ECT2, two guanine exchange factors that are essential for activation and recruitment of RhoA to the cleavage furrow for completion of cytokinesis, must be downregulated sequentially for Mk to undergo ..
  23. Kathy K Griendling; Fiscal Year: 2014
    ..ability to oxidize actin, thus leading to changes in the binding of actin regulatory proteins, and to facilitate RhoA-mediated focal adhesion formation...
  24. Nucleotide-Mediated Foam Cell Formation in Smooth Muscle Cells
    TIXIEANNA DISSMORE; Fiscal Year: 2012
    ..Study 3 will use inhibitors and dominant negative mutants of RhoA, Rac and cd42 to determine whether small GTPases are critical for P2Y2R mediated LDL uptake...
  25. Integrin Mechanotransduction and caveolae-based signaling complexes
    VICTOR J RIZZO; Fiscal Year: 2012
    ..Specifically, integrins associate with a caveolae-based phospho-caveolin/Src/Csk complex which governs RhoA activity and reorganization of the actin cytoskeleton and inhibition of cell cycle in response to shear stress...
  26. THEODOSIA ANASTASIOS KALFA; Fiscal Year: 2015
    ..b>RhoA GTPase is known to play a significant role in cytokinesis and abscission of the daughter cells...
  27. Regulation of Cytokinesis and Tumor Formation by RhoA
    ANN LOUISE MILLER; Fiscal Year: 2013
    ..Finally, I will test whether cytokinesis failure induced by other Rho zone regulators, especially those that are up- or down-regulated or mutated in human tumors, promotes tumor formation. ..
  28. Zeiss Laser TIRF 3 microscope and live cell imaging system
    Joseph E Mazurkiewicz; Fiscal Year: 2010
    ..and tumor cell invasion;use of the FRET based biosensor, Raichu, to assess the distribution of Rac, CDC42 and RhoA in migrating cells;the assembly of the phagocytic cup as vesicles bringing new membrane to the assembly site, ..
  29. Regulation of cell division in Trypanosoma brucei
    Ziyin Li; Fiscal Year: 2011
    ..phosphorylation of the centralspindlin complex at the central spindle and subsequent activation of the RhoA GTPase at the furrow for further activation of actin and myosin to form the actomyosin ring (Carmena, 2008)...
  30. Role of an unusual GTPase in DNA damage response and carcinogenesis
    Sam W Lee; Fiscal Year: 2012
    ..RhoE is a recent addition of the small GTPases superfamily and has the strongest homology to RhoA, B, and C...
  31. Alda Tufro; Fiscal Year: 2016
    ..by evaluating sema3a-induced nephrin turnover, plexinA1-MICAL interaction, MICAL requirement, and modulation of RhoA, CRMP and [unreadable]3 integrin by sema3a...
  32. Gary L Johnson; Fiscal Year: 2015
    ..suggest the CCM phenotype is caused by an increase in EC cytoskeletal stability resulting from dysregulation of RhoA. We have discovered that the small GTPase Rap1 is also dysregulated in CCM...
  33. Christopher F Dibble; Fiscal Year: 2014
    ..Loss of CCM1, -2 or -3 protein results in a significant increase in total and active RhoA, along with increased Rho kinase (ROCK) and ROCK effector activity...
  34. The role of RhoA and its targets in craniofacial cartilage morphogenesis
    BARBARA SISSON; Fiscal Year: 2010
    ..This proposal is based on the hypothesis that RhoA and its targets are the effectors of the noncanonical Wnt/PCP pathway controlling chondrocyte stacking in zebrafish...
  35. PHYSIOLOGICAL CHEMISTRY OF INTEGRIN FUNCTION
    MICHAEL LORAN DUSTIN; Fiscal Year: 2010
    ..the potential of high-density presentation of chemokines to alter LFA-1 interaction affinity and pattern through RhoA mediated activation of myosin IIA...
  36. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2012
    ..Moreover, we showed that activities of RhoA, Rac1 and Cdc42 are sensitive to ATP depletion, but that the activity of each protein is differentially affected by ..
  37. Christopher S Chen; Fiscal Year: 2016
    ..Specific Aim 2 will examine the role of RhoA and cytoskeletal tension in stiffness- and cadherin-induced cycling...
  38. Adhesion and Migration in Inflammation
    Keith Burridge; Fiscal Year: 2010
    ..The roles of the Rapt, RhoA and Rac1 GTPases will be investigated in this process...
  39. Jerome W Breslin; Fiscal Year: 2015
    ..We hypothesize that Rnd3 promotes endothelial barrier restoration after inflammatory challenges by inhibiting RhoA/ROCK-mediated cell contraction and activating Rac1-mediated enhancement of intercellular junction integrity...
  40. Transcriptional regulation of c-fos and immediate early genes
    Ron Prywes; Fiscal Year: 2009
    ..of the SRF cofactors, the ternary complex factors (TCFs), and the second is signaling through the small GTPase RhoA. In this proposal the pathways used by RhoA to activate the c-fos promoter will be studied...
  41. Klaus M Hahn; Fiscal Year: 2016
    ..Aim 1 will examine the dynamics of activation of key Rho proteins (RhoA, Rac1, RhoG and Cdc42) in response to engagement and crosslinking of E-selectin and ICAM- 1 on lung microvascular ..
  42. JOYCE MARIE SLINGERLAND; Fiscal Year: 2014
    ..Cytoplasmic p27 acquires an oncogenic gain of function to promote cell motility by binding RhoA to inhibit RhoA-ROCK activation needed for cytoskeletal stability...
  43. MICHAEL A GLOTZER; Fiscal Year: 2016
    ..The mechanism by which the master regulator of this process, the small GTPase RhoA, is activated at the equatorial cell cortex is not well understood...
  44. SIGNALING VIA THE MULTIFUNCTIONAL TRIO PROTEIN
    Haruo Saito; Fiscal Year: 2001
    Rho-like GTPases such as rhoA, rac1, and cdc42 play an essential role in growth factor-mediated changes in the actin cytoskeleton necessary for cell growth and motility...
  45. Gadiparthi N Rao; Fiscal Year: 2016
    ..2. Thrombin activates Rho GTPases via recruitment of RhoGEFs by Gab1 and RhoGEF-dependent RhoA, Rac1 and Cdc42 activation mediate HASMC F-actin stress fiber formation, migration, proliferation and neointima ..
  46. Calcium-dependent Regulation of Smooth Muscle Phenotype
    BRIAN WAMHOFF; Fiscal Year: 2010
    ..L-type voltage-gated Ca channels (VGCC) resulted in an increase in SMGX through mechanisms that are dependent on RhoA/Rho-kinase, myocardin (a SMC-selective SRF co-factor) and increased binding of SRF to CArG cis promoter regulatory ..
  47. Mechanisms of glomerular disesase progression
    Jeffrey R Schelling; Fiscal Year: 2012
    ..and Gdi-/- MCs exhibit myofibroblast features, such as alpha-smooth muscle actin (SMA) assembly and RhoA activation, as well as Rac1 suppression...
  48. Nikki L Jernigan; Fiscal Year: 2016
    ..promotes PICK1 (protein interacting with C- kinase 1)-dependent ASIC1 trafficking to the membrane through increased RhoA-mediated actin polymerization by use of cell surface biotinylation assays, [Ca2+]i imaging, and live-cell confocal ..
  49. Understanding the Regulation of Megakaroblastic Leukemia 1 (MLK1)
    THERA C ALEXIS; Fiscal Year: 2010
    ..MKL1 is required for the RhoA-dependent SRE activation and MKL1 overexpression strongly activates SREs. It is unclear how RhoA regulates MKL1...
  50. Marilyn Gist Farquhar; Fiscal Year: 2015
    ..complex, including IQGAP, MAGI- 2, CASK, and spectrins;4) Demonstration that podocalyxin expression activates RhoA and induces actin reorganization;5) Demonstration that podocalyxin can bind directly to ezrin and is ..
  51. The Role of Local BDNF Synthesis in Spine Morphogenesis
    LAUREN LYNN OREFICE; Fiscal Year: 2012
    ..dendritic translation and secretion of proBDNF, which interacts with p75[NTR] to mediate spine pruning through RhoA in cultured hippocampal neurons...
  52. Nox4 and Cardiac Fibrosis
    Dan Sorescu; Fiscal Year: 2012
    ..CTGF) by controlling activation of transcription factors Smad2/3;2) Nox4 binds to and regulates the small GTPase RhoA which in turns controls activation and nuclear translocation of transcription factors Smad2/3;3) the novel redox-..
  53. Hyaluronan and CD44 are Novel Targets for Acute Lung injury
    Patrick A Singleton; Fiscal Year: 2013
    ..produced in pathological states by hyaluronidase enzymes) occupies CD44 variant 10 (CD44v10) and mediates RhoA-dependent actin stress fiber formation and EC barrier disruption...
  54. Qun Lu; Fiscal Year: 2014
    ..We have identified that suppression of RhoA signaling by p160ROCK/Rho kinase inhibitor Y-27632, which inhibits cancer cell motility and invasion, can reverse ..
  55. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..The effector of RhoA GTPase, Rho-kinase (ROCK) and other kinases, phosphorylate MLCP targeting subunit (MYPT1), at Thr696 and Thr853 and ..
  56. Molecular genetics of epithelium formation in C. elegans
    Stephen E Von Stetina; Fiscal Year: 2010
    ..Further work from the Mango lab showed that CYK-4 regulates RhoA activity and actomyosin contractility to initiate polarization of the C. elegans zygote...
  57. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..The functions of small GTPases such as Ras and RhoA are relatively well understood, but there exists a variety of large molecular weight GTPases whose functions are ..
  58. Physiology of Respiratory Muscle Micromechanics
    ALADIN BORIEK; Fiscal Year: 2009
    ..Our specific aims are: Specific Aim # 1: To evaluate the role of the small GTPase proteins of Rho family such as RhoA, Racl and cdc42 in the mechanical stretch-induced signal transduction in normal skeletal muscles...
  59. TRPC-mediated calcium signaling in podocytes
    Anna Greka; Fiscal Year: 2012
    ..In contrast, TRPC6-mediated Ca2+ influx increases RhoA activity, inhibiting podocyte migration...
  60. Mechanism and role of DLC-1 tumor suppressor loss in lung cancer
    Channing J Der; Fiscal Year: 2012
    ..In addition to RhoA, we also determined that the RhoGAP domain regulates the biologically distinct RhoB and RhoC isoforms, as well as ..
  61. Kevin J Whitehead; Fiscal Year: 2015
    ..Recent studies have suggested a potential role for increased RhoA GTPase activity in the pathogenesis of the disease...
  62. Roles for Human PARPs in Regulating the Cytoskeleton and Cell Motility
    MELISSA CHESARONE CATALDO; Fiscal Year: 2012
    ..and membrane dynamics, along with defects in the activity of a small GTPase required for proper cell motility, RhoA. The objective of the proposed research is to determine both the targets and the mechanisms of PARP-9 and PARP-14 ..
  63. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ..g. RhoGEFs/RacGEF (Tiam1) and c-Src kinase] plays an important role in HA-mediated oncogenic signaling such as the RhoA-activated ROK pathway, Tiam1-regulated Rac1-PKNgamma kinase pathway and c-Src-induced cortactin and Gab-1/PI3 ..
  64. Avril V Somlyo; Fiscal Year: 2016
    ..complex network of protein-protein interactions, which can enhance the contractile effect acting via a small GTPase RhoA. The design of molecules that would alter these interactions could provide a more specific way of therapeutic ..
  65. Asa B Gustafsson; Fiscal Year: 2015
    ..We have also identified several proteins, including the GTPase RhoA and the Rho effector diaphanous 1 (DIAPH1), that act to facilitate this movement...
  66. Investigating the RhoA/ROCK pathway for the treatment of Alzheimer's disease
    JEREMY HARTFORD HERSKOWITZ; Fiscal Year: 2013
    ..b>RhoA, a Rho GTPase family member, is a well-studied regulator of neuronal outgrowth and synaptic plasticity...
  67. Victor J Thannickal; Fiscal Year: 2016
    ..factors (matrix stiffness activation of latent TGF-[unreadable]), cell adhesion/contractile factors (integrins, RhoA), and intracellular signaling cascades (SMAD2/3, Wilm's tumor-1) that activate or repress fibrogenic gene ..
  68. Spiro Getsios; Fiscal Year: 2016
    ..differentiation, focusing on the ability of the EphA1 SAM domain to regulate the integrin-linked kinase-RhoA-[serum response factor] pathway...
  69. KENNETH ALBERT MYERS; Fiscal Year: 2015
    ..is critically dependent upon endothelial cell branching, a process driven by signaling cues from the Rac1 and RhoA GTPases that coordinate the organization of the microtubule and acto-myosin cytoskeletons...
  70. JODY GREANEY; Fiscal Year: 2015
    ..Previous data suggest that alterations in both adrenergic and RhoA/Rho kinase signaling contribute importantly to impaired vascular function in human hypertension and may have ..
  71. Tuberin &hamartin in rapamycin-sensitive &insensitive smooth muscle cell growth
    Usamah S Kayyali; Fiscal Year: 2013
    ..mitochondrial function that promotes redox-regulated apoptosis, (ii) rapamycin- insensitive activation of Rheb and RhoA that also promotes growth, and (iii) a phenotype that promotes the development of pulmonary hypertension...
  72. Liwei Huang; Fiscal Year: 2015
    ..while the noncanonical Wnts function through alternate signaling cascades that include Ca2+/PKC and RhoA/JNK...
  73. RHOA EFFECTOR IN HIV-1 REPLICATION AND PATHOGENESIS
    Lishan Su; Fiscal Year: 2004
    The long-term goals of this project are to elucidate the role and regulation of RhoA signaling pathways during HIV-1 replication and pathogenesis, and to validate a novel host (p115 RhoGEF) and viral (gp41C) targets for anti-HIV therapies...
  74. Mechanism and Prevention of Female Stress Urinary Incontinence
    Tom F Lue; Fiscal Year: 2013
    ..perturbations of urethral alpha adrenergic receptor expression, changes in expression of the cellular messengers RhoA, ROCK-I, ROCK-II, and phosphorylated myosin light chain (pMLC), and reduction in urethral collagen I and elastic ..
  75. Marco A Zarbin; Fiscal Year: 2016
    ..In retinal cell cultures, activation of the RhoA-Rho kinase (ROCK) signaling cascade is primarily responsible for rod axon retraction...
  76. FASEB SRC on Regulation and Function of Small GTPases
    KAREN M CICHOWSKI; Fiscal Year: 2013
    ..Over the last decade, many other family members have been shown to be fundamental in cancer and metastasis (RhoA, Rac1, Rab5, Rheb, RalA)...
  77. Adhesion-dependent inhibition of RhoA through Arg tyrosine kinase and p190RhoGAP
    William Bradley; Fiscal Year: 2009
    ..The RhoA GTPase (Rho) is an essential regulator of the cytoskeleton, and changes in its activity lead to alterations in the ..
  78. Farhad R Danesh; Fiscal Year: 2016
    ..is a serine/threonine protein kinase which functions as one of the downstream effectors for the small G-protein RhoA. The RhoA/ROCK pathway has an important role in mediating various cellular processes, including cytoskeletal ..
  79. Aberrant LARG and RhoA activation in human leukemias
    Channing Der; Fiscal Year: 2005
    ..Our preliminary studies determined that LARG is an activator of RhoA and can cause transformation of NIH 3T3 mouse fibroblasts...
  80. Coordinate Regulation Of Nuclear DGK-theta and PLD
    DANIEL RABEN; Fiscal Year: 2009
    ..We find that the small molecular weight GTP-binding protein RhoA reciprocally regulates two signaling enzymes, diacylglycerol kinase-theta and phospholipase D, at the nucleus in ..