RGS6

Summary

Gene Symbol: RGS6
Description: regulator of G-protein signaling 6
Alias: GAP, HA117, S914, regulator of G-protein signaling 6, regulator of G-protein signalling 6
Species: human

Top Publications

  1. pmc HA117 gene increased the multidrug resistance of K562 cells in vitro: an investigation to the function of a novel gene related to drug resistance
    Yuxia Guo
    The Affiliated Children s Hospital, Chongqing Medical University, PR China
    J Exp Clin Cancer Res 28:63. 2009
  2. ncbi Influence of neonatal estrogens on rat prostate development
    G S Prins
    Department of Urology, University of Illinois at Chicago, 60612, USA
    Reprod Fertil Dev 13:241-52. 2001
  3. ncbi [Not Available]
    A Carlino
    Istituto Universitario Europeo, Firenze
    Physis Riv Int Stor Sci 31:731-69. 1994
  4. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
  5. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
  6. pmc Emerging issues in lifestyle, social, and environmental interventions to promote behavioral change related to prevention and control of hypertension in the African-American population
    C H Edwards
    Howard University, Washington, DC, USA
    J Natl Med Assoc 87:642-6. 1995
  7. pmc Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion
    G P Connolly
    Department of Physiology, University College of London
    Br J Pharmacol 110:1297-304. 1993
  8. pmc Detachment of agglutinin-bonded red blood cells. II. Mechanical energies to separate large contact areas
    E Evans
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Biophys J 59:849-60. 1991
  9. ncbi Clinical results of unconventional fractionation radiotherapy in central nervous system tumors
    M Botturi
    Radiotherapy Department, Ospedale Niguarda Ca' Granda, Milan, Italy
    Tumori 84:176-87. 1998
  10. pmc Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis
    P Santicioli
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:1149-58. 1995

Research Grants

  1. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
  2. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
  3. Virginijus Valiunas; Fiscal Year: 2015
  4. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012
  5. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
  6. Paul D Lampe; Fiscal Year: 2016
  7. Guy A Perkins; Fiscal Year: 2015
  8. Paul L Sorgen; Fiscal Year: 2016
  9. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
  10. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013

Detail Information

Publications1763 found, 100 shown here

  1. pmc HA117 gene increased the multidrug resistance of K562 cells in vitro: an investigation to the function of a novel gene related to drug resistance
    Yuxia Guo
    The Affiliated Children s Hospital, Chongqing Medical University, PR China
    J Exp Clin Cancer Res 28:63. 2009
    A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown...
  2. ncbi Influence of neonatal estrogens on rat prostate development
    G S Prins
    Department of Urology, University of Illinois at Chicago, 60612, USA
    Reprod Fertil Dev 13:241-52. 2001
    ..altered steroid receptor expression include disruption of TGFbeta paracrine communication, altered expression of gap junction connexin molecules and loss of epithelial cadherin on epithelial cells...
  3. ncbi [Not Available]
    A Carlino
    Istituto Universitario Europeo, Firenze
    Physis Riv Int Stor Sci 31:731-69. 1994
    ..In many ways, anatomical fugitive sheets are exceptional documents through which one can measure the gap between academic knowledge and popularization and identify the iconographic and textual strategies used in order to ..
  4. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
    ..j.ps) produced by electrical field stimulation (EFS) were investigated by means of a sucrose-gap technique in the circular muscle of the guinea-pig colon. 2...
  5. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
    ..5. In electrophysiological experiments (sucrose gap), cromakalim (0.3 and 1 microM) produced hyperpolarization of ureter smooth muscle...
  6. pmc Emerging issues in lifestyle, social, and environmental interventions to promote behavioral change related to prevention and control of hypertension in the African-American population
    C H Edwards
    Howard University, Washington, DC, USA
    J Natl Med Assoc 87:642-6. 1995
    ..In conclusion, we already have the information we need from research to close the mortality gap between whites and African Americans in cardiovascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)
  7. pmc Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion
    G P Connolly
    Department of Physiology, University College of London
    Br J Pharmacol 110:1297-304. 1993
    1. Using a grease-gap technique, we have investigated the effects of purine and pyrimidine nucleotides on the d.c. potential of the rat isolated superior cervical ganglion (SCG). 2...
  8. pmc Detachment of agglutinin-bonded red blood cells. II. Mechanical energies to separate large contact areas
    E Evans
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Biophys J 59:849-60. 1991
    ..solutions of a high molecular weight polymer to draw the surfaces together by osmotic dehydration of the adhesion gap. These stresses exceeded initial mechanical assembly stresses by up to three orders of magnitude...
  9. ncbi Clinical results of unconventional fractionation radiotherapy in central nervous system tumors
    M Botturi
    Radiotherapy Department, Ospedale Niguarda Ca' Granda, Milan, Italy
    Tumori 84:176-87. 1998
    ..Different considerations have been proposed to explain this gap between theory and clinical data...
  10. pmc Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis
    P Santicioli
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:1149-58. 1995
    ..6. In sucrose gap experiments, (S)-ketoprofen (10-100 microM) produced a time-dependent shortening of spontaneous action potentials ..
  11. pmc Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve: implications for P2 purinoceptor classification
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 113:463-70. 1994
    1. By use of a 'grease-gap' technique, the depolarizing effects of adenosine 5'-triphosphate (ATP) and ATP analogues on the rat isolated vagus nerve were determined in normal and in Ca2+/Mg(2+)-free (+ 1 x 10(-3) M ethylenediamine ..
  12. pmc Delayed depolarization and slow sodium currents in cutaneous afferents
    O Honmou
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510
    J Neurophysiol 71:1627-37. 1994
    ..Whole-nerve sucrose gap recordings were obtained from the SN and the ATN...
  13. pmc Effect of the Ca(2+)-ATPase inhibitor, cyclopiazonic acid, on electromechanical coupling in the guinea-pig ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:127-37. 1995
    ..8. In sucrose gap experiments, 10 micro M CPA produced a sustained depolarization of the membrane and reduced the latency between ..
  14. ncbi The Taskforce 2000 survey on medical education in sleep and sleep disorders
    R Rosen
    Comprehensive Sleep Disorders Center, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, USA
    Sleep 21:235-8. 1998
    Previous research has shown evidence of a widening gap between scientific research and clinical teaching in sleep and sleep disorders...
  15. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    ..stimulation (EFS) in the circular muscle of the guinea-pig proximal colon was investigated by means of a sucrose-gap technique. 2. In the presence of 1 microM atropine, submaximal EFS (10 Hz, 20-30 V, 0...
  16. ncbi Development of artificial articular cartilage
    M Oka
    Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Japan
    Proc Inst Mech Eng H 214:59-68. 2000
    ..As regards lubrication, the changes in thickness and fluid pressure of the gap formed between a glass plate and the specimen under loading were measured and it was found that PVA-H had a thicker ..
  17. pmc Effects of PAF on excitatory neuro-effector transmission in dog airways
    K Tashiro
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 107:956-63. 1992
    ..bronchiole of the dog were investigated, by isometric tension recording, microelectrode and double sucrose-gap methods. 2...
  18. ncbi The influence of social class on health status: American and British research on health inequalities
    O Fein
    Cornell University Medical College, New York, New York 10021, USA
    J Gen Intern Med 10:577-86. 1995
    ..Use of British and American standardized mortality ratios (SMRs) shows that the gap between the advantaged upper socioeconomic classes and the disadvantaged lower classes has become wider from 1930 ..
  19. ncbi [Analysis of the current status of asthma education for children and adolescents in German-speaking countries]
    R Szczepanski

    Pneumologie 47:583-7. 1993
    ..An analysis conducted in mid-1992 revealed a considerable gap between the actual need for such training and the available training facilities...
  20. pmc Safety and efficacy of fertility-regulating methods: a decade of research
    D C Skegg
    University of Otago, Dunedin, New Zealand
    Bull World Health Organ 77:713-21. 1999
    An international venture was launched in 1985 to fill a recognized gap in post-marketing surveillance of fertility-regulating methods...
  21. ncbi Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco
    S C McKarns
    Research and Development, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA
    Toxicol In Vitro 14:41-51. 2000
    ..b>Gap junction intercellular communication (GJIC) and lactate dehydrogenase release (LDH) were used to quantify ..
  22. ncbi [Facioscapulohumeral muscular dystrophy (FSH) and hearing loss]
    T Takeya
    Department of Pediatrics, University of Tsukuba
    No To Hattatsu 22:24-9. 1990
    ..In case 1, pure tone audiograms revealed high tone hearing loss without an A-B gap. On speech audiography, the maximum articulation score was 100% and proved normal. The tympanogram was type A...
  23. ncbi Silica induced suppression of the production of third and fifth components of the complement system by human lung cells in vitro
    B L Rothman
    Department of Pathology, University of Connecticut Health Center, Farmington
    Immunopharmacol Immunotoxicol 16:525-51. 1994
    ..To begin to fill this gap in our knowledge we have recently evaluated the ability of lung tissue cells to synthesize and secrete various ..
  24. pmc The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 112:282-8. 1994
    ..5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'grease-gap' extracellular recording technique. This effect was attenuated by the P2 purinoceptor antagonist, suramin...
  25. pmc Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 110:1055-60. 1993
    ..investigated on the extracellularly recorded membrane potential of the rat isolated vagus nerve, using a 'grease-gap' technique. 2. ATP evoked depolarization of the rat vagus nerve...
  26. ncbi Is early gastric cancer, diffuse type, a forerunner of advanced gastric cancer
    P Leocata
    Dipartimento di Medicina Sperimentale, , Italy
    Tumori 79:108-11. 1993
    ..RESULTS: On an average, patients affected by EGC were 8.1 years younger than those with AGC. This age gap could support the hypothesis that early lesions represent the first stage of AGC...
  27. ncbi Immunohistochemical demonstration of the gap junctional protein connexin 32 and proliferating cell nuclear antigen in glutathione S-transferase placental form-negative lesions of rat liver induced by diethylnitrosamine and clofibrate
    S Ito
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Toxicol Pathol 24:690-5. 1996
    The distributions of a gap junctional protein, connexin 32 (cx 32), and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically in glutathione S-transferase placental form (GST-P)-negative foci, induced in rat liver ..
  28. ncbi Should the gap be filled between guidelines and actual practice for management of low back pain in primary care? The Quebec experience
    M Rossignol
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 21:2893-8; discussion 2898-9. 1996
    ..A prospective cohort study...
  29. ncbi Duration of antituberculosis chemotherapy in conjunction with radical surgery in the management of spinal tuberculosis
    S S Upadhyay
    Duchess of Kent Children s Hospital, Hong Kong
    Spine (Phila Pa 1976) 21:1898-903. 1996
    ..6 years after radical resection of the tuberculous lesion and reconstruction of the resultant gap with bone graft...
  30. pmc Attitudes towards war, killing, and punishment of children among young people in Estonia, Finland, Romania, the Russian Federation, and the USA
    A McAlister
    University of Texas Houston School of Public Health, Houston, TX, USA
    Bull World Health Organ 79:382-7. 2001
    ..CONCLUSION: The results confirm the gap between the US and European groups in moral disengagement attitudes and tendencies that could lead to deadly ..
  31. pmc Bradykinin receptors in mouse and rat isolated superior cervical ganglia
    G R Seabrook
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
    Br J Pharmacol 115:368-72. 1995
    ..and its analogues to depolarize rat and mouse superior cervical ganglia was studied by use of in vitro grease-gap recording techniques, and the ability of antagonists selective for bradykinin receptor subtypes to block their ..
  32. pmc Discrimination between UTP- and P2-purinoceptor-mediated depolarization of rat superior cervical ganglia by 4,4'-diisothiocyanatostilbene-2,2'- disulphonate (DIDS) and uniblue A
    G P Connolly
    Department of Physiology, University College London
    Br J Pharmacol 115:427-32. 1995
    1. Using a grease-gap recording technique we have investigated the effects of some antagonists of P2-purinoceptors on the depolarization of the rat isolated superior cervical ganglion evoked by 100 microM alpha, beta-methylene-adenosine ..
  33. pmc Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
    J Harvey
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 109:1085-90. 1993
    1. A grease-gap recording technique has been used to investigate the mechanisms underlying the acute potentiation of N-methyl-D-aspartate (NMDA) responses by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) in area CA1 of rat ..
  34. ncbi Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors
    M F Sugrue
    Merck Research Laboratories, West Point, PA 19486, USA
    Prog Retin Eye Res 19:87-112. 2000
    There was a time gap of over 40 years between the demonstrated oral effectiveness of acetazolamide in lowering the intraocular pressure (IOP) of glaucoma patients and the introduction of a topical carbonic anhydrase (CA) inhibitor...
  35. pmc Charge movement and SR calcium release in frog skeletal muscle can be related by a Hodgkin-Huxley model with four gating particles
    B J Simon
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550
    Biophys J 61:1109-16. 1992
    ..delta[Ca2+]) were measured simultaneously in frog skeletal muscle fibers, voltage clamped in a double vaseline gap chamber, using Antipyrylazo III as the calcium indicator...
  36. ncbi Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443
    D Hebebrand
    UCLA Hand Center, USA
    J Hand Surg Br 22:304-7. 1997
    ..Sciatic nerve grafts of 2 cm were transplanted from donor Golden Syrian hamsters into a 0.5 cm gap in the sciatic nerve of recipient Lewis rats...
  37. ncbi Axonal regeneration stimulated by the combination of nerve growth factor and ciliary neurotrophic factor in an end-to-side model
    W V McCallister
    Department of Orthopaedics, University of Washington School of Medicine, Seattle, WA 98195 6500, USA
    J Hand Surg Am 26:478-88. 2001
    ..coaptation only, end-to-side coaptation plus growth factor injection, primary repair, and nontransferred gap control...
  38. ncbi Electromechanical uncoupling in a molluscan muscle examined by the sucrose gap technique. The effect of calcium antagonist and agonist agents
    H Huddart
    Department of Zoology, University of Rhode Island, Kingston, 02881
    J Comp Physiol B 158:501-12. 1988
    Membrane potential and tension of Busycon radular protractor muscles were studied by sucrose gap methods...
  39. ncbi Physicians' and nurses' attitudes toward withholding treatment in a community hospital
    M W Frampton
    Myers Community Hospital, Sodus, New York
    J Gen Intern Med 2:394-9. 1987
    ..A significant communication gap existed between nurses and physicians regarding aggressiveness of care: physicians indicated communication with ..
  40. pmc A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated
    J V Kilmartin
    MRC Laboratory of Molecular Biology, Cambridge, England
    J Cell Biol 123:1175-84. 1993
    ..The 110-kD component is localized in the SPB to the gap between the central plaque and the sealed ends of the nuclear microtubules near the inner plaque (Rout, M., and J...
  41. ncbi A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests
    T Shirai
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 25:453-60. 1997
    ..system for rapid detection of carcinogenic agents has been developed using male Fischer 344 rats to bridge the gap between long-term carcinogenicity tests and short-term screening assays...
  42. ncbi A morphological study of the fibrous capsule of the human lumbar facet joint
    T Yamashita
    Department of Orthopaedic Surgery, Sapporo Medical University, Japan
    Spine (Phila Pa 1976) 21:538-43. 1996
    ..superior and middle part of the joint, the fibers run in the medial to lateral direction, crossing over the joint gap. In the inferior part of the joint, the fibers are relatively long and run in a superior-medial to inferior-lateral ..
  43. ncbi Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    R L Sorenson
    Department of Cell Biology and Neuroanatomy, University of Minnesota Medical School, Minneapolis 55455, USA
    Horm Metab Res 29:301-7. 1997
    ..secretion, 2) increased insulin synthesis, 3) increased beta-cell proliferation and islet volume, 4) increased gap-junctional coupling among beta-cells, 5) increased glucose metabolism, and 6) increased c-AMP metabolism...
  44. ncbi Innervation of a lizard auditory organ having gap junctions between most hair cells: a serial transmission electron microscopy study
    M R Miller
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Comp Neurol 293:223-35. 1990
    ..4. An unusual finding was the presence of gap junctions directly interconnecting more than half the hair cells in both papillar segments...
  45. ncbi [Fatal lactic acidosis in a patient with acquired immunodeficiency syndrome treated with stavudine, lamivudine and indinavir]
    K Tanaka
    First Department of Internal Medicine, Kurume University School of Medicine
    Kansenshogaku Zasshi 73:1232-5. 1999
    ..Laboratory data demonstrated a severe metabolic acidosis with an anion gap due to lactate accumulation...
  46. ncbi Genetic expression for type I procollagen in the early stages of flexor tendon healing
    R H Gelberman
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston
    J Hand Surg Am 17:551-8. 1992
    ..localized specifically to the epitenon cells on the tendon surface overlying the repair site and to cells in the gap between the tendon stumps. No detectable expression was noted in endotenon fibroblasts...
  47. pmc Employers, the government, and industrial fatigue in Britain, 1890-1918
    A J McIvor
    Department of History, University of Strathclyde, Glasgow, UK
    Br J Ind Med 44:724-32. 1987
    ..Though there are significant caveats, it is argued that before the first world war a wide gap existed between research findings, best practice, and the common workshop experience and that in general British ..
  48. ncbi Cloning of the region between HLA-DMB and LMP2 in the human major histocompatibility complex
    P Sanseau
    Department of Human Immunogenetics, Imperial Cancer Research Fund, England
    Hum Immunol 40:1-7. 1994
    ..Almost all of the class II region of the MHC has already been cloned in cosmids but a gap remained between the DMB and LMP2 genes...
  49. ncbi Mortality trends in Belgium and The Netherlands. Closing the gap
    J V Joossens
    Department of Epidemiology, University of Leuven, Belgium
    Acta Cardiol 51:9-25. 1996
    ..The mortality gap between both countries is closing, especially between The Netherlands and Flanders...
  50. ncbi Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras
    M Segal
    Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    J Biol Chem 267:22747-51. 1992
    ..the RAS1 and RAS2 loci, expressing both p21H-ras and the catalytic domain of the bovine GTPase activating protein (GAP) and containing the cdc25-2 mutation. Such a strain exhibits a temperature-sensitive phenotype...
  51. ncbi Mechanical analysis of tendon suture techniques
    D P Greenwald
    Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston
    J Hand Surg Am 19:641-7. 1994
    ..Tenorrhaphies were pulled apart at constant speed until a gap of 1 mm was observed. Strength (maximum stress) and toughness (energy absorption to gap formation) were calculated...
  52. ncbi Mechanisms of load transfer in the cadaver forearm: role of the interosseous membrane
    K L Markolf
    Biomechanics Research Section, Department of Orthopaedic Surgery, University of California at Los Angeles, USA
    J Hand Surg Am 25:674-82. 2000
    ..With varus alignment (initial gap between the radial head and capitellum) load applied to the wrist displaced the radius proximally an average of 1...
  53. ncbi Gap junctional intercellular communication of bovine granulosa and thecal cells from antral follicles: effects of luteinizing hormone and follicle-stimulating hormone
    Mary Lynn Johnson
    Endocrine 18:261-70. 2002
    ..We have shown that LH or FSH affect cellular interactions mediated by gap junctions in bovine granulosa and thecal cells in vitro...
  54. ncbi Heterocellular gap junctional communication between alveolar epithelial cells
    V Abraham
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1085-93. 2001
    We analyzed the pattern of gap junction protein (connexin) expression in vivo by indirect immunofluorescence...
  55. ncbi An application of neutron activation and radiotracer techniques for studying the status of sodium in the bone mineral
    N Pilecká
    Institute of Biophysics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 39:49-56. 1993
    ..The experiments on the bone in vitro can help to bridge a gap between in vitro experiments on synthetic hydroxy apatite and dynamic studies based on the in vivo neutron ..
  56. ncbi Comparison of ideal and actual behavior of patients and dentists during dental treatment
    S Lahti
    Department of Community Dentistry, University of Kuopio, Kuopio, Finland
    Community Dent Oral Epidemiol 23:374-8. 1995
    ..In general, there evidently is a clear gap in communication between dentists and patients, which may lead to frustration on both sides...
  57. ncbi Radiographic evaluation of osseous displacement following intra-articular fractures of the distal radius: reliability of plain radiography versus computed tomography
    R J Cole
    Orthopaedic Clinic, Memphis, TN, USA
    J Hand Surg Am 22:792-800. 1997
    ..The average maximum gap displacement on plain radiographs was 2.1 mm (range, 0.0-15.0 mm, lateral view) and on CT images was 4...
  58. ncbi Review on prostaglandin and oxytocin activity in preterm labor
    M Ivanisevic
    University Hospital for Gynaecology and Obstetrics, School of Medicine, University of Zagreb, Croatia
    Coll Antropol 25:687-94. 2001
    ..uterine contractions and indirectly to increase fundally dominant myometrial contractility by up regulation of gap junctions, oxytocin and arginine vasopressin receptors and synchronizations of contractions...
  59. pmc Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signaling
    Srikanth Damodaram
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 49:5-20. 2009
    ..nasal mucosa reside in the trigeminal ganglion in association with satellite glial cells where they communicate via gap junctions...
  60. ncbi The use of formal prior directives among patients with HIV-related diseases
    J Teno
    Center for Gerontology and Health Care Research, Providence, Rhode Island
    J Gen Intern Med 5:490-4. 1990
    ..5 times more likely to have obtained a prior directive than were those not counseled. CONCLUSIONS: A gap exists between subjects' knowledge and implementation of prior directives...
  61. pmc Health sector reform and reproductive health in Latin America and the Caribbean: strengthening the links
    A Langer
    Population Council, Regional Office for Latin America and the Caribbean LAC, Mexico DF, Mexico
    Bull World Health Organ 78:667-76. 2000
    ..With only limited changes to the health systems in many Latin American and Caribbean countries and a handful of examples of positive progress resulting from reforms, the gap between rhetoric and practice remains wide.
  62. ncbi Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro
    R D Traub
    Department of Pharmacology, Division of Neuroscience, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Neurophysiol 85:1246-56. 2001
    ..Network bursts in electrically coupled interneurons have previously been shown to be possible with dendritic gap junctions, when the dendrites were capable of spike initiation, and when action potentials could cross from cell to ..
  63. ncbi Factors affecting functional outcome of displaced intra-articular distal radius fractures
    T E Trumble
    Harborview Medical Center, University of Washington School of Medicine, Seattle 98195
    J Hand Surg Am 19:325-40. 1994
    ..The degree to which articular step-off, gap between fragments, and radial shortening are improved by surgery is strongly correlated with improved outcome, even ..
  64. pmc Internal fixation of pilon fractures of the distal radius
    T E Trumble
    Harborview Medical Center, University of Washington School of Medicine, Seattle 98195
    Yale J Biol Med 66:179-91. 1993
    ..Furthermore, the degree to which articular stepoff, gap between fragments, and radial shortening are improved by surgery is strongly correlated with improved outcome, even ..
  65. ncbi Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization
    G Senger
    Human Cytogenetics Laboratory, Imperial Cancer Research Fund, London, UK
    Hum Mol Genet 3:1275-80. 1994
    ..A set of overlapping cosmids from the HLA class II region was used to determine how precisely the actual overlap or gap between probes can be calculated from the measured overlap or gap between their signals...
  66. pmc Helicobacter pylori: therapeutic targets
    J A Louw
    Gastrointestinal Clinic, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Yale J Biol Med 71:113-7. 1998
    ..disease seen in many populations, especially from developing countries, probably contributes to this "credibility gap." While we have excellent therapeutic regimens available at this time, rational targeting requires that the ..
  67. pmc Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation
    T Krenacs
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Am J Pathol 152:993-1004. 1998
    Communicating channels called gap junctions are thought to play a ubiquitous part in cell growth and development. Based on earlier work, we have recently found functional evidence of their presence in human and mouse bone marrow...
  68. ncbi Growth-associated protein-43 messenger ribonucleic acid expression in gonadotropin-releasing hormone neurons during the rat estrous cycle
    V Prevot
    INSERM, U 422, Institut Fédératif de Recherches 22, Unité de Neuroendocrinologie et de Physiopathologie Neuronale, Lille, France
    Endocrinology 141:1648-57. 2000
    ..was designed to determine whether the intrinsic determinant of neuronal outgrowth, growth-associated protein-43 (GAP-43), was expressed in GnRH neurons of adult female rats, and whether its expression varied throughout the estrous ..
  69. ncbi Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat
    Irene C Solomon
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    J Neurophysiol 89:135-49. 2003
    Recent investigations have examined the influence of gap junctional communication on generation and modulation of respiratory rhythm and inspiratory motoneuron synchronization in vitro using transverse medullary slice and en bloc brain ..
  70. pmc Effect of an artificial disc on lumbar spine biomechanics: a probabilistic finite element study
    Antonius Rohlmann
    Julius Wolff Institut, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Spine J 18:89-97. 2009
    ..joints are affected by the input parameters implant position, implant ball radius, presence of scar tissue, and gap size in the facet joints...
  71. doi Random Gap Detection Test and Random Gap Detection Test-Expanded results in children with auditory neuropathy
    Fulya Yalçinkaya
    Hacettepe University, Faculty of Medicine, ENT Department, Division of Audiology and Speech Pathology, Ankara, Turkey
    Int J Pediatr Otorhinolaryngol 73:1558-63. 2009
    ..If the children with AN cannot distinguish the heard tones one or two in Random Gap Detection Test (RGDT), their benefit performances between hearing aids or CI may not be significant...
  72. ncbi Trends in the black-white life expectancy gap in the United States, 1983-2003
    Sam Harper
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec
    JAMA 297:1224-32. 2007
    Since the early 1980s, the black-white gap in life expectancy at birth increased sharply and subsequently declined, but the causes of these changes have not been investigated.
  73. ncbi Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium
    B D Angst
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, England
    Circ Res 80:88-94. 1997
    Nonuniformity in the spatial patterning of gap junctions between heart muscle cells is now recognized as an important determinant of electromechanical function in working myocardium...
  74. pmc Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions
    Dingbo Lin
    Department of Biochemistry, Kansas State University, 141 Chalmers Hall, Manhattan, KS 66506, USA
    Exp Eye Res 85:113-22. 2007
    ..Takemoto, D.J., 2005. Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions. J. Biol. Chem. 280, 13682-13693]...
  75. ncbi Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain
    Y Zheng
    Department of Pharmacology, Cornell University, Ithaca, New York 14853
    J Biol Chem 268:24629-34. 1993
    ..These members include human platelet GAP for Cdc42Hs (the human homolog of a S...
  76. pmc Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens
    Sondip K Biswas
    Depatment of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 13:345-59. 2007
    To determine the possible changes in the distribution of cholesterol in gap junction plaques during fiber cell differentiation and maturation in the embryonic chicken lens...
  77. doi The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease
    Parakrama Chandrasoma
    Department of Pathology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Am J Surg Pathol 34:1574-81. 2010
    ..proximally and the proximal limit of gastric oxyntic mucosa distally were defined as having a squamo-oxyntic gap. The length of the squamo-oxyntic gap varied from less than 1 cm in 1399 (84...
  78. ncbi Involvement of gap junctions in the development of the neocortex
    Bernd Sutor
    Institute of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munchen, Germany
    Biochim Biophys Acta 1719:59-68. 2005
    b>Gap junctions play an important role during the development of the mammalian brain...
  79. pmc Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis
    Lui G Forni
    Department of Critical Care, Worthing Hospital, Worthing, West Sussex, UK
    Crit Care 9:R591-5. 2005
    ..origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap. There is increasing recognition, however, of a group of acidotic patients who have a large anion gap that is not ..
  80. ncbi Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model
    Nobukazu Takahashi
    Division of Diagnostic Imaging, Box 57, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Acad Radiol 14:1050-7. 2007
    ..We previously have reported that (99m)Tc-labeled glutamate peptide-estradiol ((99m)Tc-GAP-EDL) is a useful agent for imaging functional estrogen receptor (ER) via an ER-mediated process...
  81. doi Medicare beneficiaries' knowledge of Part D prescription drug program benefits and responses to drug costs
    John Hsu
    Center for Health Policy Studies and the Division of Research, Kaiser Permanente Medical Care Program, 2000 Broadway, Third Floor, Oakland, California 94612, USA
    JAMA 299:1929-36. 2008
    ..Medicare Part D drug benefits include substantial cost sharing...
  82. ncbi Connexin 36 in photoreceptor cells: studies on transgenic rod-less and cone-less mouse retinas
    Loan Dang
    Eye Research Institute, Oakland University, Rochester, MI 48309 4481, USA
    Mol Vis 10:323-7. 2004
    Rod-cone gap junctions permit transmittal of rod visual information to the cone pathway...
  83. ncbi Lactococcus lactis glyceraldehyde-3-phosphate dehydrogenase gene, gap: further evidence for strongly biased codon usage in glycolytic pathway genes
    M R Cancilla
    Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia
    Microbiology 141:1027-36. 1995
    The gene gap, encoding glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), was isolated from a genomic library of Lactococcus lactis LM0230 DNA. Plasmids containing the L...
  84. ncbi Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells
    D F Matesic
    Department of Pediatrics Human Development, Michigan State University, East Lansing 48824
    Mol Carcinog 10:226-36. 1994
    The effects of three tumor promoters on gap-junction permeability; connexin 43 and 26 mRNA levels, protein levels, and phosphorylation; and the numbers of gap-junctional membrane plaques were studied in the rat liver epithelial cell line ..
  85. ncbi The mitral gap at 11 + 0 to 13 + 6 weeks: marker of trisomy 21 or artifact?
    N Maiz
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 30:813-8. 2007
    To investigate the possible association between a particular pulsed Doppler waveform pattern, mitral gap, and trisomy 21 at 11 + 0 to 13 + 6 weeks.
  86. ncbi Membrane topology and quaternary structure of cardiac gap junction ion channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037
    J Mol Biol 223:929-48. 1992
    The membrane topology and quaternary structure of rat cardiac gap junction ion channels containing alpha 1 connexin (i.e...
  87. ncbi cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expression
    R L Neve
    Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
    Brain Res Mol Brain Res 65:52-60. 1999
    The expression of the GAP-43 gene is controlled partly by changes in the stability of its mRNA, a process that is mediated by the interaction of specific sequences in the 3'-untranslated region (3'UTR) with neuronal-specific RNA-binding ..
  88. doi Inhibitory effect of gap junction blockers on cerebral vasospasm
    Tao Hong
    Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
    J Neurosurg 108:551-7. 2008
    The gap junction is important in the propagation of dilation/constriction signals along vessels for coordinated behavior in control of vascular tone...
  89. pmc Identification and characterization of the water gap in physically dormant seeds of Geraniaceae, with special reference to Geranium carolinianum
    N S Gama-Arachchige
    Department of Biology, University of Kentucky, Lexington, KY 40546, USA
    Ann Bot 105:977-90. 2010
    ..The chalazal cleft has been reported to be the water gap (i.e. location of initial water entry) in innately permeable seeds of Geraniaceae...
  90. ncbi Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein
    Y Zhang
    Unité 245 Institut National de la Santé et de la Recherche Médicale INSERM, Paris, France
    J Biol Chem 268:18875-81. 1993
    Human placenta contains, in addition to the ubiquitous p120-GTPase-activating protein (GAP), another isoform of 100 kDa, which is specific to this organ...
  91. pmc Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus
    J E Rash
    Department of Biomedical Sciences, Colorado State University, Campus Delivery 1617, Fort Collins, CO 80523, USA
    Neuroscience 147:938-56. 2007
    ..early postnatal development, and it has been proposed that these neurons are linked by extraordinarily abundant gap junctions consisting of connexin32 (Cx32) and connexin26 (Cx26), and that those same connexins abundantly link ..
  92. pmc Phylogeny of seed dormancy in Convolvulaceae, subfamily Convolvuloideae (Solanales)
    K M G Gehan Jayasuriya
    Department of Biology, University of Kentucky, Lexington, KY 40506, USA
    Ann Bot 103:45-63. 2009
    The water gap is an important morphoanatomical structure in seeds with physical dormancy (PY). It is an environmental signal detector for dormancy break and the route of water into the non-dormant seed...
  93. pmc Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens
    Sondip K Biswas
    Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 15:1492-508. 2009
    To investigate the structural remodeling in gap junctions associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens...
  94. ncbi Saccadic reaction time in the monkey: advanced preparation of oculomotor programs is primarily responsible for express saccade occurrence
    M Pare
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Neurophysiol 76:3666-81. 1996
    ..appearance of a peripheral saccade target produces a general reduction in saccadic reaction time (SRT)-known as the gap effect- and often very short latency express saccades...
  95. doi Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis
    Tao Huang
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Cancer Sci 101:713-21. 2010
    ..However, the mechanisms involved have not been fully elucidated. Gap junctions play important roles in the regulation of tumor cell phenotypes and mediation of the bystander effect in ..
  96. ncbi Heterogeneity in the distribution of vascular gap junctions and connexins: implications for function
    C E Hill
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Clin Exp Pharmacol Physiol 29:620-5. 2002
    1. Gap junctions, which are comprised of members of a family of membrane proteins called connexins (Cx), permit the transfer of electrical and chemical information between adjacent cells in a wide variety of tissues...
  97. doi [The epilepsy treatment gap in six primary care centres in Togo (2007-2009)]
    Kokou Mensah Guinhouya
    Service de neurologie CHU de Lomé Tokoin BP 57 Togo, Service de neurologie CHU du Campus Lomé Togo, Service de Santé des armées Lomé Togo
    Sante 20:93-7. 2010
    ..In developing countries, about 90% of those with epilepsy do not receive appropriate treatment; this treatment gap, very high compared with other chronic diseases, helps to explain the marginalisation and poor living conditions of ..
  98. pmc Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803
    F Valverde
    Instituto de Bioquimica Vegetal y Fotosintesis, Centro de Investigación Isla de la Cartuja, Universidad de Sevilla CSIC, Seville, Spain
    J Bacteriol 179:4513-22. 1997
    The gap-2 gene, encoding the NAD(P)-dependent D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH2) of the cyanobacterium Synechocystis sp...
  99. ncbi Dynamics of connexin 43 levels and distribution in the mink (Mustela vison) anterior pituitary are associated with seasonal changes in anterior pituitary prolactin content
    M L Vitale
    Departement de pathologie et biologie cellulaire, Faculte de Medecine, Université of Montréal, 2900 Edouard Montpetit, Montreal, Quebec, Canada H3T 1J4
    Biol Reprod 64:625-33. 2001
    Because in mammals the anterior pituitary lacks innervation, we investigated whether gap junctions established between selected cells within the gland are part of an intrapituitary mechanism to ensure physiological synchronization of ..
  100. ncbi A gap-junction-mediated signal, rather than an external paracrine factor, predominates during meiotic induction in isolated mouse oocytes
    S M Downs
    Biology Department, Marquette University, Milwaukee, Wisconsin 53233, USA
    Zygote 9:71-82. 2001
    This study was carried out to compare the possible role of a secreted paracrine factor versus that of a gap-junction-transmitted signal in mediating meiotic induction in isolated mouse oocytes from PMSG-primed, immature mice...
  101. ncbi Increased levels of cyclins D1 and D3 after inhibition of gap junctional communication in astrocytes
    Arantxa Tabernero
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Salamanca, Spain
    J Neurochem 96:973-82. 2006
    We showed previously that the inhibition of gap junctional communication in astrocytes increased bromodeoxyuridine (BrdU) incorporation and promoted changes in the metabolic phenotype destined to fulfil the requirements of cell ..

Research Grants89

  1. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
    ..The 5-year overall survival for patients with PDA is less than 3%. The gap junction protein connexin43 (Cx43) is a tumor suppressor gene that is expressed in pancreatic ductal cells, the ..
  2. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..Our laboratory recently identified mutations (missense and small duplication) in the gap junction protein GJA1, also referred to as connexin 43, in ODDD patients...
  3. Virginijus Valiunas; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Gap junctions provide a direct intercellular pathway for cell-to-cell signaling and impulse conduction and play an important role in normal physiology...
  4. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012
    ..Thus, mechanical stimulation increases Cx43 expression, gap junction communication and hemichannel opening in osteoblasts and osteocytes...
  5. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
    ..network organization and MAP4 binding in causing abnormal transport and localization of connexin43 [Cx43], a gap junction protein known to undergo functionally important alterations in quantity and localization during ..
  6. Paul D Lampe; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Gap junctions are specialized matched membrane domains that contain channels that allow exchange of small molecules including ions, metabolites, and second messengers (e.g...
  7. Guy A Perkins; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Gap junctions create direct cell-cell communication in most cell types...
  8. Paul L Sorgen; Fiscal Year: 2016
    ..DESCRIPTION (provided by applicant): Connexins are integral membrane proteins that oligomerize to form intercellular gap junction channels...
  9. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..My losses include a colony of connexin43 (gap junction) mutant mice, generated as recipients for cell-transplantation studies, a breeding colony of rats, as well ..
  10. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gap junctions provide for the homeostasis of nearly every tissue by metabolically, chemically, and electrically coupling the cells into a functional syncytium...
  11. Connexin-Mediated Hemichannel Activity in Experimental Periodontitis
    Karen F Ross; Fiscal Year: 2012
    ..of this project is to characterize cell-to-cell communication in oral tissues through connexin hemichannels and gap junctions in order to design new treatments for infection of mucosal tissues...
  12. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
    ..The central hypothesis that will be tested is that both connexin gap junctions and hemichannels play an important role in maintaining lens transparency...
  13. SiRNA therapeutics: Gap junction delivery in vitro and in vivo
    Richard T Mathias; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cellular delivery of siRNA via gap junctions represents a unique and potentially clinically important delivery system...
  14. Mario Delmar; Fiscal Year: 2015
    ..Here, we seek a better understanding of the association between mechanical junctions, gap junctions and the voltage-gated sodium channel (VGSC) complex...
  15. LENS CELL COUPLING--ASSEMBLY AND ROLE OF GAP JUNCTIONS
    LINDA MUSIL; Fiscal Year: 1999
    ..Three closely related types of gap junction proteins (connexins) participate in joining lens cells into a syncytium with respect to molecules smaller ..
  16. Transfer of Metabolites through Lens Gap Junctions
    Gary Goldberg; Fiscal Year: 2005
    Lens cells require gap junction proteins to communicate with each other and develop properly. In particular, connexin43 (Cx43), Cx46, and Cx5O are needed for normal lens development and function...
  17. Regulation of lens connexins
    Charles Louis; Fiscal Year: 2007
    ..Regulation of connexin-mediated gap junctional communication, and intracellular cytosolic Ca 2+ concentration ([Ca2+]i) are essential for maintaining ..
  18. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Gap junctions are microscopic intercellular junctions that provide for direct intercellular ionic, electrical, and metabolic coupling between nerve cells in the brain, retina, and spinal cord...
  19. Electrical Synapses and Network Signaling
    Gianmaria Maccaferri; Fiscal Year: 2010
    ..the preferential synaptic targets of noradrenaline in the hippocampus are GABAergic interneurons, which express the gap junction protein Connexin 36, and are organized in electrically coupled networks...
  20. Functional activity in glia
    Gerald Dienel; Fiscal Year: 2009
    ..Astrocytes are highly coupled by gap junction channels, but the functional roles of the syncytium are not well understood because dye transfer studies ..
  21. Velia M Fowler; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The transparency of the vertebrate lens depends on assembly of connexins into gap junctions that are required for lens ionic homeostasis and metabolite circulation...
  22. Internalization of gap junctions as a regulatory mechanism of direct GJIC
    Matthias M Falk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Communication between adjacent cells through gap junctions (GJs) occurs in nearly every tissue and is fundamental to coordinated cell behavior during development, differentiation, and tissue ..
  23. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..flexneri, but it is injected into the host cell cytoplasm where it may be localized to gap junctions. Because IpaD may have a role in post-invasion events (i.e...
  24. Amir Tirosh; Fiscal Year: 2016
    ..In recent years, it has been shown that gap junction channels play a pivotal role in tissue adaptation to stress and inflammation in various tissues and ..
  25. Janis M Burt; Fiscal Year: 2014
    ..understand the molecular mechanisms that govern the permeability and growth suppressive properties of vascular cell gap junctions and 2) to develop from that knowledge the rationale for gene therapies that target connexin expression in ..
  26. Thomas W White; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Connexins are the subunit proteins of gap junctions, which allow the exchange of ions, second messengers and small metabolites between adjacent cells through intercellular channels...
  27. Connexin acetylation: Impact on gap junction function and HDAC inhibitor respons
    JEANNETTE CHLOE BULINSKI; Fiscal Year: 2010
    ..b>Gap junctions are channels formed from connexin subunits that permit the passive transfer of low molecular mass ..
  28. Pharmacology of Connexin Channels: Structure-Activity Studies.
    Miduturu Srinivas; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The multi-gene family of proteins called connexins form intercellular gap junctions that directly mediate signaling between adjacent cells...
  29. Mechanisms of coronary endothelial dysfunction in diabetes
    Ayako Makino; Fiscal Year: 2011
    ..b>Gap junctions, formed by connexins (Cxs), provide important pathways for the cell-cell communication and Cx40 is known ..
  30. Thomas W White; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Connexins are the subunit proteins of gap junctions, which allow the exchange of ions, second messengers and small metabolites between adjacent cells through intercellular channels...
  31. Structure and Dynamics of Gap Junction Channels
    MARK JAY YEAGER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gap junctions are specialized regions of cell-to-cell contact in which hexameric oligomers, called connexons, dock end-to-end across a narrow extracellular gap, allowing the intercellular exchange of ..
  32. International Gap Junction Conference 2013
    Robert G Gourdie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Virtually all cells in the human body form gap junctions...
  33. YURIY KUCHERYAVYKH; Fiscal Year: 2015
    ..Unlike normal glia, glioma cells express low levels of functional connexin (Cx) hemichannel/gap junction protein and high levels of polyamines (PA)...
  34. INFLAMMATORY MECHANISMS IN LUNG VASCULAR SEGMENTS
    Kaushik Parthasarathi; Fiscal Year: 2012
    ..We will inhibit intercellular communication by blocking gap junctions and connexin expression using pharmacological and molecular mechanisms...
  35. Osteoblastic lineage cells regulate osteoclastogenesis via Cx43 and gap junctions
    Yue Zhang; Fiscal Year: 2011
    ..b>Gap junctions (GJ) are membrane-spanning channels that allow passage of ions and signaling molecules, less than 1KD in ..
  36. Mitchell J Weiss; Fiscal Year: 2016
    ..and will test whether polarization of calcium communication is determined by selective permeability of the gap junctions at the MEJ or differential expression of second messenger receptors at the MEJ in the two cell types...
  37. William Smith; Fiscal Year: 2016
    ..The connexin proteins make gap junctions.) In embryos from the frimousse (frm) mutant line, the anterior neural plate is transfated to epidermis...
  38. CONNEXONS IN CARDIOVASCULAR CELL COMMUNICATION
    Eric C Beyer; Fiscal Year: 2013
    ..b>Gap junction channels are likely to play significant roles in the stabilization and maintenance of atrial fibrillation, ..
  39. Coronary Artery Regulation by Small Conduction Ca2+-activated K+ Channels
    MARK STEPHEN TAYLOR; Fiscal Year: 2011
    ..of these Ca2+ signals to holes in the internal elastic lamina (IEL) as well as to SK3 channels and specific gap junction connexins expressed along the endothelial-vascular smooth muscle (VSM) interface, suggest the existence of ..
  40. Guy A Perkins; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Gap junctions play dynamic roles in cellular processes, however, there is a fundamental knowledge gap in understanding how gap junction proteins, the connexins, are regulated and gated based on a ..
  41. ANAMIKA MARAGRET REED; Fiscal Year: 2014
    ..proposal hypothesizes that low pH exerts its injurious effects by transforming intracellular calcium signaling and gap junctional intercellular communication in acinar cells from a physiologic pattern to one that causes pancreatitis...
  42. Miduturu Srinivas; Fiscal Year: 2014
    Abstract Gap junctional communication provided by connexin channels is required for postnatal lens growth and transparency. Targeted deletions of genes encoding Cx46 and Cx50 lead to cataracts in mice...
  43. Control of Junctional Conductance at Auditory Afferent
    Alberto Pereda; Fiscal Year: 2009
    ..objective of the proposed research is to study the role and properties of electrical synaptic transmission via gap junctions in the CNS, in particular in the auditory system...
  44. Embryonic Expression and Roles of Neuronal Connexin 35 in Zebrafish Spinal Cord
    Tara Martin; Fiscal Year: 2013
    ..Electrical synapses are formed with gap junction communications between neuronal cells that allow for the direct transfer of current...
  45. Function and Expression of Connexins in the pre-Botzinger Complex
    JONATHAN KELTY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Gap junctions are pores that span the membranes of adjacent cells, and as such provide a means of electrical and cytoplasmic continuity between those cells...
  46. Jean X Jiang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Connexin-forming gap junction intercellular communication (GJIC) is essential for the metabolic homeostasis of the lens...
  47. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..b>Gap junctions, which are formed of proteins called connexins, are a special class of cell junctions that provide a ..
  48. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
    This Program Project of 26 years duration brings together investigators with a wide range of expertise to focus on gap unctions, which are intercellular channels comprised of connexins...
  49. MECHANISMS OF CONTROL OF CELL GROWTH BY GAP JUNCTIONS
    Bruce Nicholson; Fiscal Year: 2003
    The disruption of intercellular coupling through gap junctions has long been associated with cell transformation and that the promotion phase of tumorigenesis...
  50. Mario Delmar; Fiscal Year: 2016
    ..Since its inception (in 1999), we focused on the mechanisms that regulate gap junctions formed by Connexin43 (Cx43)...
  51. JOHN PEARCE MORROW; Fiscal Year: 2015
    ..this application is that increased cardiac myocyte lipid content leads to abnormal regulation of ion channels and gap junctions, promoting arrhythmia...
  52. Roberto Civitelli; Fiscal Year: 2016
    ..During the tenure of this project, we demonstrated that bone forming cells communicate via gap junctions formed primarily by connexin43 (Cx43)...
  53. Mechanisms for Stem Cell Differentiation into Cardiac Myocytes
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..More specifically, shared cytosolic conduits, gap junctions, between adult-derived stem cells and adjacent contracting cardiomyocytes provide the route by which a ..
  54. Development of a novel connexin-based peptide for the treatment of corneal injury
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2012
    ..ACT1 works by stabilizing gap junctions and maintaining intercellular communication between cells that is essential for wound repair or injury ..
  55. SIGNAL TRANSDUCTION AT FERTILIZATION
    Laurinda A Jaffe; Fiscal Year: 2012
    ..Recent findings, which establish that gap junctions between the somatic cells of the follicle close rapidly in response to LH, form the basis for the 3 aims ..
  56. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..leading to cardiac dysfunction is not known, however, recent studies have suggested involvement of cardiac gap junction remodeling...
  57. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..activation delay in the RV, namely the localization and expression of the key conduction protein connexin-43 at the gap junctions, and its relation to electrical propagation;and 3)...
  58. Joshua M Hare; Fiscal Year: 2016
    ..engraftment and differentiation of mesenchymal stem cells (MSCs) in the injured porcine heart was accompanied by 1) gap junction formation with host cells, 2) stimulation of endogenous cardiac stem cell (CSC) proliferation and ..
  59. X Edward Guo; Fiscal Year: 2014
    ..calcium [Ca2+]i oscillations in osteocytic network, followed by prostaglandin E2 (PGE2) production/secretion via gap junctions/hemi-channels to OBs...
  60. Eliseo A Eugenin; Fiscal Year: 2016
    ..Nevertheless, our data demonstrate for first time that HIV infected astrocytes, through gap junction channels and perhaps hemichannels, can amplify inflammation and CNS damage...
  61. The Role of Gap Junctions in Peripheral Odor Coding
    Chunbo Zhang; Fiscal Year: 2004
    b>Gap junctions represent an important mode of intercellular communication in the nervous system. Gap junctions allow exchange of small bioactive substances, including second messengers, between coupled cells...
  62. Rafael Yuste; Fiscal Year: 2016
    ..role in the circuit: they tile the CNS with near- complet coverage, are connected into an extensive syncytium via gap junctions, and processes from a single astrocyte can contact up to tens of thousands of synapses...
  63. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..for uveal coloboma, an abnormal development of the eye caused by incomplete closure of a normally-occurring gap in the eye (the optic fissure) after the fifth week of life in a human embryo...
  64. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..for uveal coloboma, an abnormal development of the eye caused by incomplete closure of a normally-occurring gap in the eye (the optic fissure) after the fifth week of life in a human embryo...
  65. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  66. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    Extensive literature has reported altered expression and/or mutation of the primary gap junction proteins (connexins, Cx) that couple myocytes in ventricles (Cx43) and atria (Cx40) among major causes of cardiac arrhythmias...
  67. Adam C Miller; Fiscal Year: 2014
    ..formed in a regulated manner between only a subset of potentially available partners and are composed of neuronal gap junction channels...
  68. Richard T Mathias; Fiscal Year: 2014
    ..The circulation depends on fiber cell gap junctions to conduct intracellular fluxes of ions and perhaps fluid, which flow from the center to surface of the ..
  69. Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes
    PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013
    ..within the mineralized matrix of bone and communicate with one another and with osteoblasts and osteoclasts via gap junctions located at the ends of long cytoplasmic processes that course through tunnels (cannalicula) in the bone...
  70. Jonathan Savitz; Fiscal Year: 2016
    ..I am currently an assistant professor at the Laureate Institute for Brain Research (LIBR) focusing on bridging the gap between immune dysfunction and neuroimaging abnormalities in major depressive disorder (MDD)...
  71. Maria Diakonova; Fiscal Year: 2014
    ..both PAK1 and PRL have been implicated in breast cancer, the proposed studies may ultimately fill out the existing gap between upstream PRL-PRLR-JAK2 events and downstream PAK1-dependent functions in our understanding of the mechanism ..
  72. JAMES EWBANK HALL; Fiscal Year: 2016
    ..Lens cells have glucose transporters, chloride channels, sodium and potassium channels, gap junctions, and many other standard transport proteins in common with the cells of other organs...
  73. David W Piston; Fiscal Year: 2016
    ..This effect parallels that seen in islets lacking [unreadable]-cell gap junctions, where insulin secretion can be inhibited by juxtacrine communication mediated by ephrinA-EphA signaling ..
  74. Zhongcong Xie; Fiscal Year: 2016
    ..However, the pathogenesis of POCD is still largely unknown, and this gap in knowledge impedes further studies of POCD...
  75. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..The proposed research aims to study the role of gap junctions during the several days of "maturation" of neuronal injury after global ischemia...
  76. ALBERT HONG JAE KIM; Fiscal Year: 2016
    ..of novel Cdc20-APC downstream mechanisms in the control of dendrite morphogenesis will fill a significant gap in our understanding of cell-intrinsic mechanisms of neuronal connectivity and provide insights into the ..
  77. Jan A Nolta; Fiscal Year: 2015
    ..techniques we have determined that this cell-contact-dependent intercellular transfer does not occur through small gap junctions but rather through exosomal transport and direct shuttle of small RNA species through tunneling ..
  78. Xue Han; Fiscal Year: 2016
    ..how neurons work together in intact neural circuits to generate computations: electrical synapses, mediated by gap junction connections that directly electrically couple cells together...
  79. Stephen G Weber; Fiscal Year: 2014
    ..We also will develop a means to diminish the astrocytes'ability to communicate with each other through gap junctions based on focal electroporation of siRNA for the protein that creates the gap junctions...
  80. KAREN MARIE BUSSARD; Fiscal Year: 2014
    ..bone models that mimic human breast cancer metastasis in-vivo to determine if 1) breast cancer cells form gap junctions with bone stromal cells, 2) alterations in mesenchymal stem cell-derived factors regulate breast cancer ..
  81. VISUAL ADAPTATION IN THE VERTEBRATE RETINA
    Harris Ripps; Fiscal Year: 2005
    The vertebrate retina is a highly ordered neuronal network in which electrical coupling through gap junctions influences every aspect of retinal function...
  82. Jean F Regal; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how placental ischemia during pregnancy leads to maternal hypertension and the only effective cure is early delivery of the placenta...
  83. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..However, there is a significant gap in our knowledge and understanding of whether early exposure to certain bacteria also acts as an important ..
  84. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..In the testis, morphological studies in the 1970s reported the presence of desmosome-gap junctions (also known as desmosome-like junctions) between adjacent Sertoli cells at the blood-testis barrier, as ..
  85. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..Instead, other factors must be involved, but have yet to be identified. The overarching challenge and knowledge gap addressed by this grant is that we do not know the determinants of daily functioning in BPD...
  86. MYOMETRIAL GAP JUNCTION MODULATION IN PRETERM LABOR
    WILLIAM LARSEN; Fiscal Year: 1990
    ..both preterm and normal term labor is the rapid and dramatic development of a functional population of myometrial gap junctions in the final 24-72 hours prior to parturition...
  87. GAP JUNCTIONS AND LUTEAL FUNCTION
    ANNA GRAZUL BILSKA; Fiscal Year: 1999
    ..3), 4) the relationship of gap junctional intercellular communication with progesterone production by luteal cells (Exp...
  88. Molecular Analysis and Role of RGS6 as a Novel Growth Suppressor
    Rory A Fisher; Fiscal Year: 2010
    ..Here we provide new evidence suggesting such a role for a member of the RGS protein family, RGS6, which exists in thirty-six splice forms possessing identical RGDs but structural variations in other protein ..
  89. Increasing efficacy of antineoplastic drugs with gap junction enhancers
    Thu Annelise Nguyen; Fiscal Year: 2010
    ..Most normal cells have functional gap junctional intercellular communication (GJIC), while most, if not all, tumors cells have dysfunctional GJIC...