RGS4

Summary

Gene Symbol: RGS4
Description: regulator of G-protein signaling 4
Alias: RGP4, SCZD9, regulator of G-protein signaling 4, schizophrenia disorder 9
Species: human

Top Publications

  1. ncbi Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure
    Clemens Mittmann
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Abteilung für Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Cardiovasc Res 55:778-86. 2002
  2. doi Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway
    Kyoung Seob Song
    The Airway Mucus Institute, Yonsei University College of Medicine, Seoul 120 752, Korea
    Am J Respir Cell Mol Biol 41:40-9. 2009
  3. pmc Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
    Yan Xie
    Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer Res 69:5743-51. 2009
  4. ncbi Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity
    S G Popov
    Pharmacology and Biochemistry Departments, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:18962-8. 2000
  5. ncbi Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4)
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Biol Psychiatry 60:534-7. 2006
  6. doi Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart
    Takeshi Tokudome
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 117:2329-39. 2008
  7. doi Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
    Andrew Stuart Gibbons
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    Aust N Z J Psychiatry 42:740-5. 2008
  8. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
  9. ncbi Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure
    V J Owen
    National Heart and Lung Institute at Imperial College School of Medicine, London, UK
    Eur Heart J 22:1015-20. 2001
  10. ncbi Association and linkage analyses of RGS4 polymorphisms in schizophrenia
    Kodavali V Chowdari
    Department of Psychiatry, University of Pittsburgh, School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, PA 15213, USA
    Hum Mol Genet 11:1373-80. 2002

Research Grants

  1. Cell-based Screen for RGS Modulators
    Richard R Neubig; Fiscal Year: 2010
  2. Song Li; Fiscal Year: 2015
  3. ANDREW MICHAEL SIEDLECKI; Fiscal Year: 2015
  4. Design of Small Molecules Acting at Regulators of G Protein Signaling
    Richard R Neubig; Fiscal Year: 2012
  5. RGS PROTEINS AND PROTEIN TRAFFICKING
    HERBERT LIN; Fiscal Year: 2003
  6. HTS for Small Molecule Modulators of RGS Proteins
    DAVID ROMAN; Fiscal Year: 2007
  7. Consequences of In Vivo Neocortical GAD67 Downregulation
    Karoly Mirnics; Fiscal Year: 2012
  8. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
  9. S MURTHY KARNAM; Fiscal Year: 2016
  10. Function and Mechanisms of the N-End Rule Pathway
    Yong Tae Kwon; Fiscal Year: 2007

Detail Information

Publications196 found, 100 shown here

  1. ncbi Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure
    Clemens Mittmann
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Abteilung für Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Cardiovasc Res 55:778-86. 2002
    ..We investigated the expression of RGS proteins in the human heart and whether they take part in the pathophysiological changes of heart failure...
  2. doi Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway
    Kyoung Seob Song
    The Airway Mucus Institute, Yonsei University College of Medicine, Seoul 120 752, Korea
    Am J Respir Cell Mol Biol 41:40-9. 2009
    ..These results give additional insights into the molecular mechanism of negative regulation of mucin overproduction and enhance our understanding of mucus hypersecretion during airway mucosal inflammation...
  3. pmc Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
    Yan Xie
    Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cancer Res 69:5743-51. 2009
    ..We identified regulator of G-protein signaling 4 (RGS4) as a novel suppressor of breast cancer migration and invasion, important steps of metastatic cascades...
  4. ncbi Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity
    S G Popov
    Pharmacology and Biochemistry Departments, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:18962-8. 2000
    ..Amino acid substitutions in helix 5 within the RGS domain of RGS4 reduce binding affinity and inhibition by PIP(3) but do not affect inhibition of GAP activity by palmitoylation...
  5. ncbi Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4)
    Pat Levitt
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Biol Psychiatry 60:534-7. 2006
    ..Regulator of G-protein signaling 4 (RGS4) has been implicated as such a gene from three lines of evidence...
  6. doi Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart
    Takeshi Tokudome
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 117:2329-39. 2008
    ..In the present report, we examined the role of regulator of G-protein signaling subtype 4 (RGS4), a GTPase activating protein for G(q) and G(i), in the antihypertrophic effects of GC-A.
  7. doi Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
    Andrew Stuart Gibbons
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    Aust N Z J Psychiatry 42:740-5. 2008
    Regulator of G-protein signalling 4 (RGS4) modulates signal transduction through several neurotransmitter receptor systems associated with the pathology of schizophrenia...
  8. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
    ..003). The 3-locus model involved the IL3 (rs2069803), RGS4 (rs2661319), and DTNBP1 (rs2619539) genes...
  9. ncbi Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure
    V J Owen
    National Heart and Lung Institute at Imperial College School of Medicine, London, UK
    Eur Heart J 22:1015-20. 2001
    ..In light of recent data on RGS proteins, we have evaluated mRNA and protein expression of RGS3, RGS4 and Gialpha2 in the myocardium from normal, end-stage failing and acutely failing unused donor hearts.
  10. ncbi Association and linkage analyses of RGS4 polymorphisms in schizophrenia
    Kodavali V Chowdari
    Department of Psychiatry, University of Pittsburgh, School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, PA 15213, USA
    Hum Mol Genet 11:1373-80. 2002
    ..analyses of postmortem cerebral cortex suggest that transcription of the regulator of G-protein signaling 4 (RGS4) is decreased in a diagnosis-specific manner in subjects with schizophrenia...
  11. pmc The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, Room 11B 08, Building 10, National Institute of Allergy and Infectious Diseases, 10 Center Drive, MSC 1876, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Biochem J 371:973-80. 2003
    ..differentially express RGS1, RGS2, RGS3S (short-form), RGS3L (long-form), PDZ-RGS3 (PDZ domain-containing) and RGS4. The aorta prominently expresses mRNAs for all these RGS proteins except PDZ-RGS3...
  12. ncbi Support for RGS4 as a susceptibility gene for schizophrenia
    Nigel M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:192-5. 2004
    ..Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples...
  13. ncbi Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 129:23-6. 2004
    The regulator of the G-protein signaling 4 (RGS4) gene was shown to have a different expression pattern in schizophrenia patients in a microarray study...
  14. ncbi Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:213-9. 2005
    Polymorphisms of the gene encoding the regulator of G-protein signaling subtype 4 (RGS4) may confer risk for schizophrenia...
  15. ncbi Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia
    F Zhang
    Department of Mental Health, University of Aberdeen, Scotland, UK
    Genes Brain Behav 4:444-8. 2005
    We investigated the RGS4 as a susceptibility gene for schizophrenia in Chinese Han (184 trios and 138 sibling pairs, a total of 322 families) and Scottish (580 cases and 620 controls) populations using both a family trio and case-control ..
  16. pmc Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 77:918-36. 2005
    ..Six genes (RGS4, SCA1, GRM4, DPYSL2, NOS1, and GRID1) met this criterion for schizophrenia or schizoaffective disorder; five ..
  17. pmc Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
    Michael E Talkowski
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:152-62. 2006
    Associations between schizophrenia (SCZ) and polymorphisms at the regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide polymorphisms [SNPs] 1, 4, 7, and 18)...
  18. ncbi Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis
    Dawei Li
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Eur J Hum Genet 14:1130-5. 2006
    ..Systematic positional, expression and functional studies have implicated the regulator of G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes as promising and novel candidates for explaining schizophrenia...
  19. ncbi RGS4 polymorphisms and risk of schizophrenia: an association study in Han Chinese plus meta-analysis
    Shengzhen Guo
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Neurosci Lett 406:122-7. 2006
    ..analysis, genetic linkage and association studies have suggested that the regulator of G-protein signaling 4 (RGS4) might be a schizophrenia susceptibility gene...
  20. pmc Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biol Psychiatry 63:32-41. 2008
    Genetic association studies, including a large meta-analysis, report association of regulator of G protein signaling 4 (RGS4) with schizophrenia in the context of heterogeneity...
  21. ncbi An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
    Hon Cheong So
    Department of Psychiatry, University of Hong Kong, Hong Kong, China
    Am J Med Genet B Neuropsychiatr Genet 147:77-85. 2008
    The regulator of G-protein signaling 4 (RGS4) has been suggested as a candidate gene for schizophrenia...
  22. ncbi Confirming RGS4 as a susceptibility gene for schizophrenia
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004
    A recent study identified a putative association between variants in the regulator of G-protein signalling 4 (RGS4) and schizophrenia, Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]...
  23. ncbi Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G alpha-GTP binding...
  24. doi Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11
    Aikaterini Karakoula
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
    Eur J Pharmacol 587:16-24. 2008
    ..receptor, signalling by both receptors was similarly inhibited by expression of either RGS2 or RGS3, whereas RGS4 has little effect...
  25. pmc Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells
    Patrick Kleemann
    Lehrstuhl für Pharmakologie und Toxikologie, Institut fur Pharmazie, Universitat Regensburg, Regensburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:261-74. 2008
    ..The RGS-proteins RGS4 and GAIP enhanced SDF-1alpha-stimulated GTP hydrolysis...
  26. ncbi Measurement of heterotrimeric G-protein and regulators of G-protein signaling interactions by time-resolved fluorescence resonance energy transfer
    Wayne R Leifert
    CSIRO Molecular and Health Technologies, Adelaide, SA 5000, Australia
    Anal Biochem 355:201-12. 2006
    ..assay to monitor heterotrimeric G-protein subunit interactions and the interaction of the G alpha subunit with RGS4. The assay uses a FRET pair consisting of a terbium cryptate chelate donor spectrally matched to an Alexa546 fluor ..
  27. pmc Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors
    Xinhua Wang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    EMBO J 26:2768-76. 2007
    ..Thus, SPL and NRB bind all members of the R4 subfamily of RGS proteins tested (RGS1, RGS2, RGS4, RGS16) and GAIP...
  28. pmc Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986
    David L Roman
    Division of Medicinal and Natural Products Chemistry, University of Iowa College of Pharmacy, Iowa City, Iowa 52242, USA
    Mol Pharmacol 78:360-5. 2010
    ..Here, we find that CCG-4986 inhibits RGS4 function through the covalent modification of two spatially distinct cysteine residues on RGS4...
  29. pmc RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels
    C A Doupnik
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 94:10461-6. 1997
    ..m2 receptors or serotonin 1A receptors were dramatically accelerated by coexpression of either RGS1, RGS3, or RGS4, but not RGS2...
  30. doi Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor
    Ingrid Langer
    Department of Biological Chemistry and Nutrition, Faculty of Medicine, UniversitéLibre de Bruxelles, Brussels, Belgium
    Mol Pharmacol 75:502-13. 2009
    ..that CCK2R-mediated inositol phosphate production, known to be G(q)-dependent, is more sensitive to RGS2 than to RGS4 and is insensitive to RGS8. Both basal and agonist-stimulated activities of the CCK2R are regulated by RGS2...
  31. ncbi Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue
    Abel Hiol
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:19301-8. 2003
    ..L., Waheed, A. A., Hiol, A., Ward, R. J., Davey, P. C., Nini, L., Wang, J., Milligan, G., Jones, T. L. Z., and Druey, K. M. (2003) J. Biol. Chem. 278, 19309-19316) was critical for RGS16 and RGS4 GAP activity.
  32. ncbi Regulators of G-protein signalling: multifunctional proteins with impact on signalling in the cardiovascular system
    Thomas Wieland
    Institut fur Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Maybachstrasse 14 16, D 68169 Mannheim, Germany
    Pharmacol Ther 97:95-115. 2003
    ..The exact functions of these proteins remain mostly elusive, but RGS proteins such as RGS4 are involved in the regulation of G(i)-protein betagamma-subunit-gated K(+) channels...
  33. ncbi Regulators of G-protein signaling 4 in adrenal gland: localization, regulation, and role in aldosterone secretion
    Damian G Romero
    Division of Endocrinology, G V Sonny Montgomery VA Medical Center, and Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Endocrinol 194:429-40. 2007
    ..On screening for adrenal zona glomerulosa-specific genes, we found that RGS4 was exclusively localized in the zona glomerulosa of the rat adrenal cortex...
  34. doi RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node
    Carlo Cifelli
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Circ Res 103:527-35. 2008
    ..Our results demonstrate that RGS4 mRNA levels are higher in the SAN compared to right atrium...
  35. doi Regulator of G-protein signalling expression and function in ovarian cancer cell lines
    Jillian H Hurst
    Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA
    Cell Mol Biol Lett 14:153-74. 2009
    ..b>RGS4 and RGS6 transcripts were expressed at dramatically different levels in ovarian cancer cell lines as compared to ..
  36. ncbi Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo
    Chad E Beyer
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1022:214-20. 2004
    ..Our group recently showed that RGS4 effectively GAPs Galpha(i)-mediated signaling in CHO cells expressing the serotonin-1A (5-HT(1A)) receptor...
  37. ncbi Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter
    Javier Garzón
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, E 28002 Madrid, Spain
    Neuropharmacology 48:853-68. 2005
    ..co-precipitated with delta-opioid receptors, Gi/o/z/q proteins, and the regulators of G-protein signalling RGS4, RGS9-2, RGS14, RGSZ1 and RGSZ2...
  38. pmc Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent
    Jeffery N Talbot
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    J Neurochem 112:1026-34. 2010
    ..Purified RGS domain of RGS4 added to permeabilized cells resulted in a twofold loss in DAMGO potency but had no effect in cells expressing RGS-..
  39. ncbi Distribution of RGS4 mRNA in mouse brain shown by in situ hybridization
    S Nomoto
    Laboratory for Genes of Motor Systems, RIKEN, Nagoya, Japan
    Biochem Biophys Res Commun 241:281-7. 1997
    ..Some, including RGS4, have been shown to act as GTPase-activating proteins for several members of the Gi alpha subunits and the Gq alpha ..
  40. pmc The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro
    S Popov
    Pharmacology Department, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9041, USA
    Proc Natl Acad Sci U S A 94:7216-20. 1997
    ..We have demonstrated that the RGS domains of RGS4, RGS10, and GAIP retain GTPase accelerating activity with the Gi class substrates Gialpha1, Goalpha, and Gzalpha in ..
  41. pmc Characterization of the GRK2 binding site of Galphaq
    Peter W Day
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
    J Biol Chem 279:53643-52. 2004
    ..Finally, although the mutant Galpha(q)-T187K has greatly reduced binding to RGS2 and RGS4, it has little to no effect on binding to GRK2...
  42. ncbi Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins
    Guyu Ho
    Wyeth Neuroscience Research, Wyeth Research, Princeton, N J, USA
    Pharmacology 79:114-21. 2007
    ..Expression of either regulator of G protein signaling 2 or 4 (RGS2 or RGS4) proteins significantly attenuated the quinpirole-induced SRE activation...
  43. ncbi Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions
    Jean Marc Taymans
    Central Nervous System Discovery Research, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Neurochem 84:1118-27. 2003
    ..of the dopamine D1 and D2 receptors on the gene expression of the five most abundant RGS in the striatum: RGS2, RGS4, RGS8, RGS9 and RGS10. Only changes in RGS2 and RGS4 mRNA levels were observed...
  44. ncbi Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay
    David L Roman
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, 1303 MSRB III, Ann Arbor, MI 41809, USA
    Mol Pharmacol 71:169-75. 2007
    ..The aim of this project was to identify inhibitors of RGS4. Using a Luminex 96-well plate bead analyzer and a novel flow-cytometric protein interaction assay to assess Galpha-..
  45. ncbi Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits
    T Wieland
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitats Krankenhaus Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 275:28500-6. 2000
    ..Analogous mutants of Galpha(q) (Galpha(q)K215E) and RGS4 (RGS4E87K) were created and studied in COS-7 cells...
  46. pmc RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
    Min Jae Lee
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:15030-5. 2005
    ..Here, we report that the ATE1 Arg-transferase mediates the in vivo degradation of RGS4 and RGS5, which are negative regulators of specific G proteins whose functions include cardiac growth and ..
  47. ncbi Differential effects of RGS proteins on G alpha(q) and G alpha(11) activity
    Graham Ladds
    Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cell Signal 19:103-13. 2007
    ..This provided an assay for the specific activity of human RGS proteins. RGS1, RGS2, RGS3 and RGS4 inhibited the spontaneous activity of both G alpha(q) and G alpha(11) but, in contrast, RGS5 and RGS16 were much ..
  48. doi S1P receptor signalling and RGS proteins; expression and function in vascular smooth muscle cells and transfected CHO cells
    Mariëlle C Hendriks-Balk
    Dept Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Pharmacol 600:1-9. 2008
    ..The mRNA expression of the S1P(1) receptor, RGS4 and RGS16 were down-regulated in VSMCs during phenotypic modulation induced by culturing, whereas mRNA levels of ..
  49. pmc Assembly of high order G alpha q-effector complexes with RGS proteins
    Aruna Shankaranarayanan
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    J Biol Chem 283:34923-34. 2008
    ..RGS2 and, to a lesser extent, RGS4 are negative allosteric modulators of Galpha(q) binding to either p63RhoGEF or GRK2...
  50. pmc A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen
    Rebecca A Roof
    Department of Pharmacology, University of Michigan, 1301 MSRB III SPC 5632, 1150 W, Medical Center Dr, Ann Arbor, MI 48109, USA
    BMC Pharmacol 9:9. 2009
    ..We recently described a focused one-bead, one-compound (OBOC) library screen to identify peptide inhibitors of RGS4. Here we extend our observations to include another peptide with a different mechanism of action.
  51. pmc RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo
    Inigo Ruiz de Azua
    Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:7999-8004. 2010
    ..To address this issue, we initially demonstrated that MIN6 insulinoma cells express functional M3Rs and that RGS4 was by far the most abundant RGS protein expressed by these cells...
  52. ncbi Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis
    J J Tesmer
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell 89:251-61. 1997
    ..We report here the 2.8 A resolution crystal structure of the RGS protein RGS4 complexed with G(i alpha1)-Mg2+-GDP-AlF4 . Only the core domain of RGS4 is visible in the crystal...
  53. ncbi Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling
    K M Druey
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20852, USA
    J Biol Chem 274:18836-42. 1999
    ..core domain but have divergent amino-terminal sequences that are the site of palmitoylation for RGS-GAIP and RGS4. We investigated the function of palmitoylation for RGS16, which shares conserved amino-terminal cysteines with ..
  54. ncbi RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development
    C Wu
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:2773-84. 2000
    ..Injection of Xenopus embryos with RNA encoding rat RGS4 (rRGS4), a GAP for G(i) and G(q), resulted in shortened trunks and decreased skeletal muscle...
  55. ncbi Profile of RGS expression in single rat atrial myocytes
    C A Doupnik
    Department of Physiology and Biophysics and Neuroscience Program, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Biochim Biophys Acta 1522:97-107. 2001
    ..endogenously expressed in atrial myocytes which were also identified in poly(A)(+) mRNA from rat atria (RGS2, RGS3, RGS4, RGS6, RGS10, GAIP, and RGSZ2)...
  56. pmc Generation and characterization of Rgs4 mutant mice
    Nicolas Grillet
    CNRS UMR 8542, Department of Biology, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Mol Cell Biol 25:4221-8. 2005
    ..However, those have just begun to be explored in vivo. Here, we describe a mouse line deficient for Rgs4, a gene normally expressed early on in discrete populations of differentiating neurons and later on at multiple ..
  57. pmc Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortex
    P J Ebert
    Department of Pharmacology, Vanderbilt University School of Medicine, 465 21st Avenue South, MRB III, Room 8114, Nashville, TN 37232, USA
    Neuroscience 142:1145-61. 2006
    ..to create transgenic mice that express GFP under the control of endogenous regulator of G-protein signaling 4 (RGS4) enhancer elements. This report focuses on expression patterns in the developing and mature cerebral cortex...
  58. ncbi Gi and RGS proteins provide biochemical control of androgen receptor nuclear exclusion
    Avi Rimler
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 31:1-12. 2007
    ..No evidence for Gq activation by melatonin was found. However, Gi/Gq-selective RGS4 inhibited AR nuclear exclusion downstream of PKC activation--an effect that was abrogated by constitutively active ..
  59. ncbi Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits
    Y Tu
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9041, USA
    Science 278:1132-5. 1997
    ..of Galpha-interacting protein (GAIP), another RGS protein, and palmitoylation of Galphai1 inhibited its response to RGS4. The extent of inhibition of Gz GAP, GAIP, RGS4, and RGS10 correlated roughly with their intrinsic GAP activities ..
  60. ncbi RGS2: a multifunctional regulator of G-protein signaling
    John H Kehrl
    B Cell Molecular Biology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biochem Cell Biol 34:432-8. 2002
    ..In addition, RGS2 shares an N-terminal membrane targeting domain with RGS4 and RGS16. Found in many cell types, RGS2 expression is highly regulated...
  61. ncbi High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 13th Street, Building 149 4309, Charlestown, MA 02129, USA
    Mol Cell Neurosci 24:106-16. 2003
    ..We find that RGS3 and RGS4 are constitutively expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ..
  62. ncbi Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors
    Xinhua Wang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    Nat Cell Biol 7:405-11. 2005
    ..SPL also binds RGS1, RGS4, RGS16 and GAIP...
  63. pmc Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors
    Zhihua Xie
    Department of Pharmacology, School of Basic Medicine and Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, 5 Dong Dan San Tiao, Beijing 100005, China
    Eur J Pharmacol 565:45-53. 2007
    ..Co-expression of RGS1, RGS2, RGS4, RGS9, RGS10 or RGS19 (Galpha-interacting protein (GAIP)) significantly reduced [Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol]-..
  64. doi RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function
    Steven Gu
    Department of Physiology, University of Toronto, ON, Canada
    Clin Sci (Lond) 116:391-9. 2009
    ..Three members of the RGS (regulator of G-protein signalling) superfamily RGS2, RGS4 and RGS5 have been implicated in the attenuation of G-protein signalling pathways in vascular and cardiac myocytes, ..
  65. doi Regulators of G protein signalling proteins in the human myometrium
    Graham Ladds
    Clinical Sciences Research Institute, University of Warwick Medical School, UHCW Campus, Clifford Bridge Road, Coventry CV2 2DX, UK
    Eur J Pharmacol 610:23-8. 2009
    ..RGS2 and RGS5 were the most abundantly expressed isolates in each of the patient groups. The levels of RGS4 and RGS16 (and to a lesser extent RGS2 and RGS14) increased in term labouring samples relative to the other groups...
  66. doi Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells
    Mariëlle C Hendriks-Balk
    Dept Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Pharmacol 606:25-31. 2009
    ..VSMCs were stimulated with S1P and mRNA expression levels of RGS2, RGS3, RGS4, RGS5 and RGS16 were measured by real-time polymerase chain reaction...
  67. doi Acute stress responsive RGS proteins in the mouse brain
    Gyeongwha Kim
    Department of Anatomy and Neurobiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju 660 751, Korea
    Mol Cells 30:161-5. 2010
    ..It was also revealed that RGS4 protein amount was consistent with mRNA level, indicating RGS4 protein may have regulatory roles in the acute ..
  68. ncbi RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells
    D J Shuey
    Department of CNS Disorders, Wyeth Ayerst Research, Princeton, New Jersey 08543 8000, USA
    J Neurochem 70:1964-72. 1998
    ..This RGS protein and RGS4 are reported to be expressed predominantly in brain, and in situ hybridization studies have revealed similarities ..
  69. doi Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1
    Mayumi Miyamoto-Matsubara
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan
    Ann N Y Acad Sci 1200:112-9. 2010
    ..This effect was not observed for RGS4 and RGS5 proteins...
  70. ncbi Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha
    Thomas Benzing
    Renal Division and Center for Clinical Research, University Hospital Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    J Biol Chem 277:32954-62. 2002
    ..14-3-3 inhibited the function of wild-type RGS7, but not that of either RSG7(P436R) or RGS4, two proteins that do not bind 14-3-3...
  71. ncbi Regulation of RGS mRNAs by cAMP in PC12 cells
    D J Pepperl
    Parke Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA
    Biochem Biophys Res Commun 243:52-5. 1998
    ..Using antisense riboprobes selective for rat RGS4, RGS7, and RGS2, we examined the regulation of these RGS mRNAs in PC12 cells in response to agents which elevate ..
  72. ncbi RGS4 inhibits G-protein signaling in cardiomyocytes
    P Tamirisa
    Center for Cardiovascular Research, Department of Medicine, and the Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 99:441-7. 1999
    ..RGS genes are expressed in heart tissue and in cultured cardiomyocytes. There is evidence that altered RGS gene expression may contribute to the pathogenesis of cardiac hypertrophy and failure...
  73. ncbi Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)
    S Harder
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Endocrinology 142:1188-94. 2001
    ..We found that regulator of G protein signaling 4 (RGS4), which differentially inhibits signaling by other receptors that couple to Gq, inhibits TRH-..
  74. ncbi Endotoxin induces desensitization of cardiac endothelin-1 receptor signaling by increased expression of RGS4 and RGS16
    Monica Patten
    Medizinische Klinik, Abteilung fur Kardiologie, Universitäts Krankenhaus Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, FRG
    Cardiovasc Res 53:156-64. 2002
    ..We therefore examined the expression of the G proteins G(i), G(q), and G(s) and of four 'regulators of G protein signaling' (RGS) proteins, RGS1, RGS4, RGS5, and RGS16 in rat hearts.
  75. ncbi Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain
    Tatsuya Ingi
    Department of Neurophysiology, Brain Research Institute, Niigata University, 1 Asahi machi, Niigata 951 8585, Japan
    Eur J Neurosci 15:929-36. 2002
    ..we performed a systematic survey of the localization of mRNAs encoding three subtypes of the RGSs (RGS2, RGS4 and RGS7) in developing rat brains by in situ hybridization through postnatal day 2 (P2), P10 and P18 to adult...
  76. ncbi Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2
    Kedan Lin
    Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    J Biol Chem 277:40789-98. 2002
    ..Yet transfection of regulator of G protein-signaling protein, RGS2 and RGS4, which inhibit Galpha(q/11) activity, indicated that Galpha(q/11) and Ca(2+) mobilization were required for SRF ..
  77. ncbi Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures
    Stephen J Gold
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurochem 82:828-38. 2002
    ..At 24 h following a chronic ECS regimen, RGS4, -7, and -10 mRNA levels were reduced by 20-30%; only RGS10 was significantly reduced 24 h after acute ECS...
  78. pmc Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation
    Qingli Zhang
    Department of Physiology and Biophysics, University of South Florida College of Medicine, Tampa, Florida 33612 4799, USA
    J Physiol 545:355-73. 2002
    ..m2 receptors at varying levels of G protein expression were examined with or without the co-expression of either RGS4 or RGS7 in Xenopus oocytes...
  79. ncbi Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine
    Martine Garnier
    Department of Neurobiology Research, GlaxoSmithKline Pharmaceuticals, Milan, Italy
    J Pharmacol Exp Ther 304:1299-306. 2003
    ..During the development of hyperalgesia, RGS4 was the only isoform examined whose mRNA levels increased significantly (up to 230%) in the lumbar spinal cord...
  80. ncbi Regulation of RGS proteins by chronic morphine in rat locus coeruleus
    Stephen J Gold
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390, USA
    Eur J Neurosci 17:971-80. 2003
    ..Immunoblot analysis of RGS4 revealed a striking divergence between mRNA and protein responses in LC: protein levels are elevated twofold ..
  81. ncbi Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor
    Stephen C Tovey
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
    Mol Pharmacol 66:1453-64. 2004
    ..Although gross indices of signaling were unaffected by RGS4, it slowed the rate of increase in Ins(1,4,5)P3 levels...
  82. ncbi Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity
    John R Hepler
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    Biochemistry 44:5495-502. 2005
    ..When reconstituted with M2 muscarinic receptors (M2) plus either Gi or Go, RGS4 (which has no RBD/GL domain) and full-length RGS14 each markedly stimulates the steady-state GTPase activities of ..
  83. pmc Can RGS4 polymorphisms be viewed as credible risk factors for schizophrenia? A critical review of the evidence
    Michael E Talkowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Schizophr Bull 32:203-8. 2006
    ..In this review, we consider such evidence in relation to the regulator of G-protein signaling 4 (RGS4), a gene localized to chromosome 1q23...
  84. ncbi Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4)
    Mie A Rizig
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:296-300. 2006
    The chromosome 1q23.3 region, which includes the RGS4 gene has been implicated in genetic susceptibility to schizophrenia by two linkage studies with lod scores of 6.35 and 3.20 and with positive lod between 2.00 and 3...
  85. ncbi Acute amphetamine down-regulates RGS4 mRNA and protein expression in rat forebrain: distinct roles of D1 and D2 dopamine receptors
    Marek Schwendt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 96:1606-15. 2006
    ..In the present study, the regulation of amphetamine-induced decrease of RGS4 expression in the rat forebrain was evaluated...
  86. ncbi Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein
    Ju Shi
    Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Neuropharmacology 51:524-35. 2006
    ..Galphaq and RGS insensitive mutant Galphaq did not produce significant alterations in the levels of Galpha11, RGS2, RGS4, RGS7, RGS16 or 5-HT2A proteins...
  87. ncbi Modulation of subfamily B/R4 RGS protein function by 14-3-3 proteins
    Maria Abramow-Newerly
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Cell Signal 18:2209-22. 2006
    ..Here, we identify a novel interaction between RGS proteins (RGS4, RGS5, RGS16) and the multifunctional protein 14-3-3...
  88. pmc Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic SCID mouse model
    M Niedergethmann
    Faculty of Medicine Mannheim, Department of Surgery, University Hospital Mannheim, University of Heidelberg, Mannheim 68135, Germany
    Br J Cancer 97:1432-40. 2007
    ..Eight genes (PAI-1, BNIP3l, VEGF, NSE, RGS4, HSP27, GADD45A, PTPN14) were chosen and validated in a semi-quantitative immunohistochemical analysis, which ..
  89. doi Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
    Eur J Hum Genet 16:1275-82. 2008
    ..great effort, to satisfactorily confirm previously reported associations between schizophrenia and the genes RGS4 and NOS1AP/CAPON...
  90. doi Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling
    Leonidas J Leontiadis
    Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Center for Scientific Research Demokritos, Ag Paraskevi Attikis, Athens, Greece
    Cell Signal 21:1218-28. 2009
    In vitro studies have shown that the Regulator of G protein Signaling 4 (RGS4) interacts with the C-termini of mu- and delta-opioid receptors (mu-OR, delta-OR) (Georgoussi et al., 2006, Cell. Signal.18, 771-782)...
  91. doi Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands
    Erich H Schneider
    University of Regensburg, Department of Pharmacology and Toxicology, Regensburg, Germany
    Biochem Pharmacol 78:607-16. 2009
    ..to improve this system for ligand screening purposes, the effects of the regulators of G-protein signaling (RGS) RGS4 and RGS19 (GAIP) were investigated...
  92. doi Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample
    János M Réthelyi
    Department of Psychiatry and Psychotherapy, Semmelweis University, 1083 Balassa u 6, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 153:792-801. 2010
    ..of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A...
  93. pmc Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle
    Fang Li
    Department of Neuroscience, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA
    Gene 451:45-53. 2010
    Regulator of G-protein signaling 4 (Rgs4) regulates the strength and duration of G-protein signaling, and plays an important role in cardiac development, smooth muscle contraction and psychiatric disorders...
  94. pmc RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity
    A Siedlecki
    Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Transplant 10:231-41. 2010
    ..b>RGS4 is a GTPase activating protein that promotes the deactivation of Gq and Gi family members...
  95. pmc Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins
    Levi L Blazer
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Pharmacol 78:524-33. 2010
    ..We report a high-throughput time-resolved fluorescence resonance energy transfer screen to identify inhibitors of RGS4 and describe the first reversible small-molecule inhibitors of an RGS protein...
  96. doi Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain
    Guadalupe Rivero
    Department of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain
    Neurochem Int 57:722-9. 2010
    ..Expression of RGS4 and RGS10 proteins was characterized in human prefrontal cortex attending to methodological (subcellular ..
  97. pmc A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins
    Levi L Blazer
    Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, United States
    Biochemistry 50:3181-92. 2011
    ..It has an IC(50) for RGS4 of 30 nM and is >20-fold selective for RGS4 over other RGS proteins...
  98. pmc Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism
    Jeff S Davies
    School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, United Kingdom
    J Biol Chem 286:15227-39. 2011
    ..and protein binding partners of a candidate AP-1R sequence were determined for a novel FRA-2-repressed gene, Rgs4. FRA-2 protein preferentially associated with a proximal Rgs4 AP-1R sequence as demonstrated by ex vivo ChIP and in ..
  99. pmc A forward genetic screen in mice identifies mutants with abnormal cortical patterning
    Seungshin Ha
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Center for Developmental Biology and Regenerative Medicine, Seattle Children s Research Institute, University of Washington School of Medicine, Seattle, WA 98101, USA
    Cereb Cortex 25:167-79. 2015
    ..ENU) mutagenesis was performed using mice expressing LacZ reporter genes in layers II/III and V of the cortex (Rgs4-lacZ) or in corticofugal axons (TAG1-tau-lacZ). Four lines with abnormal cortical lamination have been identified...
  100. ncbi EF1α is a suitable housekeeping gene for RT-qPCR analysis during osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells
    Xingyun Chen
    The Molecular Biology Center, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, P R China
    Acta Biochim Pol 60:381-6. 2013
    ..When we used RGS4 mRNA, which was determined as copy number per μg of total RNA, to normalize gene expression, we observed that the ..
  101. pmc Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI
    Mikko O Laukkanen
    IRCCS SDN, Naples, Italy
    PLoS ONE 10:e0121441. 2015
    ..nucleotide-exchange factors (RHO GEF16, RAL GEF RGL1), GTPase-activating proteins (ARFGAP ADAP2, RAS GAP RASAL1, RGS4), and a Rho guanine nucleotide-disassociation inhibitor (RHO GDI 2) in a dose dependent manner, thus controlling ..

Research Grants32

  1. Cell-based Screen for RGS Modulators
    Richard R Neubig; Fiscal Year: 2010
    ..We have recently developed a robust cell- based functional assay for assessing RGS4 activity...
  2. Song Li; Fiscal Year: 2015
    ..Genomewide functional proteomic approach led us to identify a set of cardiovascular regulators (Rgs4, Rgs5, and Rgs16) as substrates of Ate1-dependent arginylation that may underlie, at least partially, Ate1-..
  3. ANDREW MICHAEL SIEDLECKI; Fiscal Year: 2015
    ..The renal-specific activity of Regulator of G protein Signaling 4 (RGS4) will be investigated as it applies to ischemia and subsequent reperfusion injury...
  4. Design of Small Molecules Acting at Regulators of G Protein Signaling
    Richard R Neubig; Fiscal Year: 2012
    ..Overexpression of RGS4 has been reported in rodent neuropathic pain models and abused drugs such as opioids and psychostimulants also ..
  5. RGS PROTEINS AND PROTEIN TRAFFICKING
    HERBERT LIN; Fiscal Year: 2003
    ..This application will present preliminary data showing a novel direct interaction between RGS4 and RGS-GAIP with the COPI coatomer protein beta'-COP...
  6. HTS for Small Molecule Modulators of RGS Proteins
    DAVID ROMAN; Fiscal Year: 2007
    ..would provide utility for studying various disease in which RGS proteins could play a role, including Parkinson's disease (RGS9), Schizophrenia (RGS4), as well as cell proliferation and metastasis (LARG). [unreadable] [unreadable]
  7. Consequences of In Vivo Neocortical GAD67 Downregulation
    Karoly Mirnics; Fiscal Year: 2012
    ..g. SYN2, RGS4, MOG, SST, NPY, GAD67, HSP70, AMPA etc)...
  8. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..Preliminary data suggest that chronic cocaine SA down- regulates RGS4, a negative regulator of D2 receptor coupling, and Akt phosphorylation, a protein kinase inhibited by G protein-..
  9. S MURTHY KARNAM; Fiscal Year: 2016
    ..and (ii) that both PKA and PKG induce relaxation by inhibiting specific targets (RGS4, IP3R-I, RhoA, and MYPT1) in the signaling pathways mediating contraction...
  10. Function and Mechanisms of the N-End Rule Pathway
    Yong Tae Kwon; Fiscal Year: 2007
    ..the degradation of various proteins (Sindbis virus RNA polymerase, HIV integrase, the Listeria monocytogenes p60, RGS4 and RGS16, and the encephalomyocarditis virus 3C protease)...
  11. MECHANISMS UNDERLYING MELATONIN RECEPTOR FUNCTION
    PAULA WITT ENDERBY; Fiscal Year: 1999
    ..cells, and 3) We will determine the effects of putative regulators of G-protein function, that is, tubulin and RGS4, on G-protein function using anti-sense knock down, immunoblot, GTP exchange and GTP hydrolysis assays...
  12. Cellular Adaptations to Neuroleptic Treatment in the Dorsal Striatum
    Tracy Gertler; Fiscal Year: 2009
    ..As adaptations to chronic neuroleptic administration may be different in normal versus diseased states, an RGS4 knockout mouse will be employed as a schizophrenic-like model in parallel to wildtype strains;RGS4 has been ..
  13. Proteomics of Ubiquitin-Dependent N-End Rule Pathway
    Yong Tae Kwon; Fiscal Year: 2009
    ..Preliminary characterization of candidate substrates unveiled several novel in vivo N-end rule substrates (RGS4, RGS5, RGS16, and CDC6), the first to be identified in mammals...
  14. RGS4 and Mu Opioid Receptor Signalling
    ALICIA CROWDER; Fiscal Year: 2003
    ..Additionally, they will examine changes that occur in the cellular localization of RGS4 in response to chronic mu agonist stimulation. The specific aims are designed to answer the following: 1...
  15. RGS4 Polymorphisms and Neurobiology of Schizophrenia
    Konasale Prasad; Fiscal Year: 2009
    ..the in vivo biological impact of variations in the gene encoding regulator of G-protein signaling subtype 4 (RGS4) polymorphisms in schizophrenia patients, individuals at risk for schizophrenia and matched healthy subjects...
  16. Imaging the Impact of Glutamate Liability Genes in Schizophrenia
    Angus Macdonald; Fiscal Year: 2009
    ..1) The first stage will test whether five glutamate moderating genes (RGS4, DTNBP1, GRM3, NRG1, and DAOA) are associated with individual differences in context processing in a large general ..
  17. OPIOID RECEPTOR MECHANISMS
    John R Traynor; Fiscal Year: 2010
    ..An understanding of roles for RGS proteins in the actions of mu-opioids may lead to improvements in the treatment of pain as well as treatment of opioid and stimulant abuse. ..
  18. SYNERGY BETWEEN SSRIS AND OVARIAN HORMONES
    NANCY MUMA; Fiscal Year: 2009
    ..The proposed studies may lead to novel targets for medications which affect the regulation of RGSZ-1 to treat women who suffer from hot flashes and mood disorders during menopause ..
  19. RGS Protein Regulation of G Protein Coupled Receptors
    John R Hepler; Fiscal Year: 2010
    ..These studies will define novel cellular mechanisms for regulating neurotransmitter and hormone signaling, and identify potential new molecular targets for therapeutic intervention in cardiovascular diseases. ..
  20. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..
  21. Role of Lipid Rafts in Adenylyl Cyclase Sensitization
    John Traynor; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. The Role of Cholinergic Functions in Alzheimer's Disease
    Zhen Yan; Fiscal Year: 2007
    ..Such knowledge should offer important insights into the cellular and molecular basis of AD and the development of new pharmacological agents in the treatment of this disease. ..
  23. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Functions of Dopamine D4 Receptors in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2007
    ....
  25. 16th Biennial Meeting of the International Society for Developmental Neurobiology
    Pat Levitt; Fiscal Year: 2006
    ..Such interactions are essential if we are to attack these problems in a cohesive, rational fashion. [unreadable] [unreadable] [unreadable]..
  26. Dopaminergic Influences on Brain Formation and Function
    GREGG STANWOOD; Fiscal Year: 2006
    ..abstract_text> ..
  27. Neuromodulator Actions in Prefrontal Cortical Neurons
    Zhen Yan; Fiscal Year: 2006
    ..Knowledge gained from this work would contribute to the development of novel therapeutic strategies for many neurological and mental disorders. ..
  28. Signaling Diversity Among Gqa Family Members
    JOHN HEPLER; Fiscal Year: 2004
    ..Information gained from these studies will help us to better understand G proteins as therapeutic targets. ..
  29. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..
  30. FETAL COCAINE AND GENE EXPRESSION DEFECTS IN FOREBRAIN
    Pat Levitt; Fiscal Year: 2002
    ..abstract_text> ..
  31. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  32. REGULATION OF HYPOTHALAMIC SIGNALING BY RGS4 PROTEIN
    NANCY MUMA; Fiscal Year: 2001
    ..We have demonstrated that overexpression of one particular RGS protein, RGS4, can induce desensitization of one member of the 5-HT2 receptor family in cells in culture...