RFTN1

Summary

Gene Symbol: RFTN1
Description: raftlin, lipid raft linker 1
Alias: MIG2, PIB10, PIG9, RAFTLIN, raftlin, cell migration-inducing gene 2 protein, proliferation-inducing protein 10, proliferation-inducing protein 9, raft-linking protein
Species: human

Top Publications

  1. pmc The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress
    Dakshayini G Chandrashekarappa
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cell Signal 28:1881-1893. 2016
  2. pmc Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription
    Josephine A Tidwell
    Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712, USA
    Mol Immunol 49:260-72. 2011
  3. doi Raftlin: a new biomarker in human sepsis
    Wonhwa Lee
    College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak ro, Buk Gu, Daegu, 702 701, Republic of Korea
    Inflammation 37:706-11. 2014
  4. doi Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Biochem J 458:195-201. 2014
  5. pmc Coregulated expression of the Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high-pH stress
    Albert Serra-Cardona
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain
    Mol Cell Biol 34:4420-35. 2014
  6. pmc Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae
    Karen L Hinkle
    Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA
    Environ Toxicol Chem 35:1727-32. 2016
  7. doi Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    J Immunol 196:3865-76. 2016
  8. pmc The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate
    Marc Andre Comeau
    Departement de Biologie, Faculté de science, Universite de Sherbrooke, Sherbrooke, Québec J1E 2R1, Canada
    Nucleic Acids Res 44:7911-21. 2016
  9. doi Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling
    Koko Moriya
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Anal Biochem 511:1-9. 2016
  10. pmc Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells That Maintains the Structure and Activity of Mig1 Protein Repressor Complex
    Montserrat Vega
    From the Department of Biochemistry and Molecular Biology, University of Oviedo, 33006 Oviedo, Spain
    J Biol Chem 291:7267-85. 2016

Research Grants

  1. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2003
  2. "Calling Cards" for DNA-binding proteins: A tool for their genome-wide mapping
    ROBI MITRA; Fiscal Year: 2008
  3. Mitochondria and Mutagenesis
    Keshav K Singh; Fiscal Year: 2010
  4. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
  5. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav K Singh; Fiscal Year: 2010

Scientific Experts

  • Ali A Ashkar
  • Mingzhi Zhang
  • Vasiliki Gkretsi
  • Keshav Singh
  • H Zhou
  • Christoph W Basse
  • M Proft
  • Jakub Orzechowski Westholm
  • M Johnston
  • C J Carter
  • Megumi Tatematsu
  • Alejandra Fernández-Cid
  • Kazuko Saeki
  • ROBI MITRA
  • Tsukasa Seya
  • Misako Matsumoto
  • Fernando Moreno
  • Montserrat Vega
  • Pilar Herrero
  • Ayako Watanabe
  • Akihiko Yoshimura
  • Marc Andre Comeau
  • Karen L Hinkle
  • Dakshayini G Chandrashekarappa
  • Koko Moriya
  • Albert Serra-Cardona
  • Wonhwa Lee
  • Jan W Farfsing
  • Alberto Riera
  • M Firoz Mian
  • Jian Huan Chen
  • Sheelarani Karunanithi
  • Mei Kee Lim
  • Josephine A Tidwell
  • Yunxiang Zhu
  • Hailong Cao
  • Sooraj Kuttykrishnan
  • Stuart Macgregor
  • Joaquin Arino
  • Chris Cotsapas
  • Robert S Boyd
  • Yan Zheng
  • Chris Hlynialuk
  • Steen Lund Westergaard
  • Amelie Avet-Rochex
  • M Axel Wollmer
  • Kathrin Auffarth
  • Joseph M Gozgit
  • Yuan Qi
  • Daisuke Aki
  • Maria Platara
  • Jens Nielsen
  • Cecília Alves-Araújo
  • Vijayendran Raghevendran
  • Aneta Kaniak
  • C Roca
  • L L Lutfiyya
  • Blake Forkey
  • Carl Vitzthum
  • Daniel A Lafontaine
  • Chad C Anderson
  • Kenji Funami
  • Kelsey Cone
  • Allyson F O'Donnell
  • Yuka Morioka
  • Kanako Matsuzaki
  • Emi Takamitsu
  • Ryuji Yoshida
  • Mayumi Kimoto
  • Martin C Schmidt
  • Noriko Ishii
  • Aya Kiwado
  • Toshihiko Utsumi
  • Jacob Griffin
  • Sherif Abou Elela
  • Rhonda R McCartney
  • Darlene Olsen
  • Sae Kwang Ku
  • Shin Woo Kim
  • David Canadell
  • Jose Ramos
  • Hayoung Yoo
  • Jong Sup Bae
  • Silvia Petrezselyova
  • Mehrnaz Rad
  • Amna N Ahmed
  • Fumiko Nishikawa
  • Artem Babaian
  • L Olsson
  • Dawn Bowdish

Detail Information

Publications50

  1. pmc The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress
    Dakshayini G Chandrashekarappa
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cell Signal 28:1881-1893. 2016
    ..The effect of low glucose and alkaline stresses was examined for two Snf1 phosphorylation substrates, the Mig1 and Mig2 proteins. Any of the three isoforms was capable of phosphorylating Mig1 in response to glucose stress...
  2. pmc Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription
    Josephine A Tidwell
    Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712, USA
    Mol Immunol 49:260-72. 2011
    ..In sum, this report introduces Brightlike as an additional functional member of the family of ARID proteins, which should be considered in regulatory circuits, previously ascribed to be mediated by Bright...
  3. doi Raftlin: a new biomarker in human sepsis
    Wonhwa Lee
    College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak ro, Buk Gu, Daegu, 702 701, Republic of Korea
    Inflammation 37:706-11. 2014
    b>Raftlin is a major protein in lipid raft. The aim of this study was to evaluate blood levels of raftlin in septic patients. A prospective study of 82 patients with sepsis was conducted...
  4. doi Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Biochem J 458:195-201. 2014
    ..Both dsRNA and structured RNA are similarly internalized through clathrin- and raftlin-dependent endocytosis and delivered to endosomal TLR3...
  5. pmc Coregulated expression of the Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high-pH stress
    Albert Serra-Cardona
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain
    Mol Cell Biol 34:4420-35. 2014
    ..Crz1 through the calcium-activated phosphatase calcineurin, and it is under the control of several repressors (Mig2, Nrg1, and Nrg2) coordinately regulated by the Snf1 protein kinase and the Rim101 transcription factor...
  6. pmc Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae
    Karen L Hinkle
    Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA
    Environ Toxicol Chem 35:1727-32. 2016
    ..Among the most significantly up-regulated genes were regulators of carbohydrate transport, including HXT1, HXT3, HXT4, IMA5, MIG2, and YKR075C. Environ Toxicol Chem 2016;35:1727-1732. © 2015 SETAC.
  7. doi Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    J Immunol 196:3865-76. 2016
    ..We have previously shown that Raftlin is essential for clathrin-dependent endocytosis of TLR3 ligand in human epithelial cells and myeloid dendritic ..
  8. pmc The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate
    Marc Andre Comeau
    Departement de Biologie, Faculté de science, Universite de Sherbrooke, Sherbrooke, Québec J1E 2R1, Canada
    Nucleic Acids Res 44:7911-21. 2016
    ..Mutational analysis of U5 snRNA and Mig2 mRNA confirms the pairing of the cleavage site as a major determinant for the difference between cleavage rates of ..
  9. doi Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling
    Koko Moriya
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Anal Biochem 511:1-9. 2016
    ..As a result, EEPD1, one of five proteins (RFTN1, EEPD1, GNAI1, PDE2A, RNF11) found to be dually acylated, was shown to be a novel dually fatty acylated protein...
  10. pmc Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells That Maintains the Structure and Activity of Mig1 Protein Repressor Complex
    Montserrat Vega
    From the Department of Biochemistry and Molecular Biology, University of Oviedo, 33006 Oviedo, Spain
    J Biol Chem 291:7267-85. 2016
    ..context, Hxk2 functions through a variety of structurally unrelated factors, mainly the DNA-binding Mig1 and Mig2 repressors and the regulatory Snf1 and Reg1 factors...
  11. doi Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma
    Jian Huan Chen
    Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou, China
    Invest Ophthalmol Vis Sci 53:779-85. 2012
    Genome-wide association studies have shown association of the atonal homolog 7 (ATOH7) and raftlin lipid raft linker 1 (RFTN1) genes with glaucoma-related optic disc parameters...
  12. doi Glucose levels regulate the nucleo-mitochondrial distribution of Mig2
    Alejandra Fernández-Cid
    Department of Biochemistry and Molecular Biology, University of Oviedo, 33006 Oviedo, Spain
    Mitochondrion 12:370-80. 2012
    b>Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Thus, until now, the main role assigned to Mig2 has been the functional redundancy to Mig1...
  13. ncbi Phenotypic characterization of glucose repression mutants of Saccharomyces cerevisiae using experiments with 13C-labelled glucose
    Vijayendran Raghevendran
    Centre for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, Lyngby DK 2800, Denmark
    Yeast 21:769-79. 2004
    ..Furthermore, deletion of the genes MIG1, MIG1/MIG2 and REG1 did not result in a significant change in the phenotype at the fluxome level.
  14. ncbi High-resolution computational models of genome binding events
    Yuan Qi
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA
    Nat Biotechnol 24:963-70. 2006
    ..We present results on the yeast transcription factors Gcn4 and Mig2 to demonstrate JBD's spatial resolution capabilities and show that positional priors allow computational discovery ..
  15. doi Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type
    M Firoz Mian
    2 Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    J Leukoc Biol 94:1025-36. 2013
    ..Finally, long poly I:C required SR-A, whereas short poly I:C required RIG-I and Raftlin. We provide evidence that the length of dsRNA drives distinct innate responses in different cell lineages...
  16. doi Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Nat Commun 4:1833. 2013
    ..acid, a synthetic double-stranded RNA, these RNAs are internalized into cells via raftlin-mediated endocytosis and colocalized with TLR3...
  17. ncbi Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer
    Vasiliki Gkretsi
    Department of Biomedical Research and Technology, Institute for Research and Technology Thessaly I RE TE TH, 51 Papanastasiou Street, Larissa 41222, Greece
    Anticancer Res 33:1977-81. 2013
    ..Mitogen-inducible gene-2 (MIG2), is a cell-matrix adhesion protein, which through migfilin, interacts with filamin-A, being linked to actin ..
  18. ncbi Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer
    Joseph M Gozgit
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA
    Mol Cancer Res 4:905-13. 2006
    ..Using real-time reverse transcription-PCR, we found that mitogen-inducible gene 2 (MIG2) is expressed at a 17-fold higher level in TMX2-28 cells than in nonaggressive MCF-7 cells and that MIG2 mRNA ..
  19. pmc The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae
    Sheelarani Karunanithi
    Department of Biological Sciences, State University of New York, Buffalo, New York 14260 1300, USA
    Genetics 192:869-87. 2012
    ..including a transcriptional repressor that functions in the AMPK pathway, Mig1, and its close functional homolog, Mig2. Mig1 and Mig2 coregulated the filamentous growth pathway in response to glucose limitation, as did the AMP kinase ..
  20. pmc Yeast importin-β is required for nuclear import of the Mig2 repressor
    Alejandra Fernández-Cid
    Department of Biochemistry and Molecular Biology, University of Oviedo, 33006, Oviedo, Spain
    BMC Cell Biol 13:31. 2012
    b>Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Recently it has been reported that Mig2 has two different subcellular localizations...
  21. ncbi Isolation and characterization of the LGT1 gene encoding a low-affinity glucose transporter from Torulaspora delbrueckii
    Cecília Alves-Araújo
    Department of Biology, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Yeast 22:165-75. 2005
    ..of the gene coding for the general repressor Mig1p had no effect on LGT1 expression, but additional disruption of MIG2 in a mig1 background indicated that Mig2p or both Mig1p and Mig2p in a redundant way, act as repressors of LGT1 ..
  22. ncbi Identification of cis-active elements in Ustilago maydis mig2 promoters conferring high-level activity during pathogenic growth in maize
    Jan W Farfsing
    Max Planck Institute for Terrestrial Microbiology, Department of Organismic Interactions, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Mol Plant Microbe Interact 18:75-87. 2005
    The Ustilago maydis mig2 cluster comprises five highly homologous genes that display a pronounced plant-specific expression profile...
  23. pmc Regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae
    Aneta Kaniak
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eukaryot Cell 3:221-31. 2004
    ..The Snf3/Rgt2-Rgt1 glucose induction pathway contributes to glucose repression by inducing the transcription of MIG2, which encodes a repressor of glucose-repressed genes, and regulates itself by inducing the expression of STD1, ..
  24. ncbi Engineering of carbon catabolite repression in recombinant xylose fermenting Saccharomyces cerevisiae
    C Roca
    Centre for Process Biotechnology, BioCentrum DTU, Technical University of Denmark, 2800 Kgs Lyngby, Denmark
    Appl Microbiol Biotechnol 63:578-83. 2004
    ..S. cerevisiae CPB.CR2 (Delta mig1, XYL1, XYL2, XKS1) and CPB.MBH2 (Delta mig1, Delta mig2, XYL1, XYL2, XKS1) were analysed for changes in xylose consumption rate and ethanol production rate during ..
  25. doi A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses
    Kazuko Saeki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 182:5929-37. 2009
    ..Through proteomic analysis, we have identified a novel protein termed Raftlin (raft-linking protein) as a major protein in lipid rafts...
  26. pmc Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage
    Yunxiang Zhu
    Genzyme Corporation, Framingham, Massachusetts 01701 9322, USA
    J Biol Chem 286:14787-94. 2011
    ..Taken together with the recently reported effects of Raftlin deficiency on Th(17) differentiation, these results strongly suggest that altering the GSL composition of lipid ..
  27. doi Galactose induction of the GAL1 gene requires conditional degradation of the Mig2 repressor
    Mei Kee Lim
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Block MD4, Singapore 117597
    Biochem J 435:641-9. 2011
    ..galactose induction of the GAL1 gene and we have found that galactose-induced protein degradation of the repressor Mig2 is defective in this strain...
  28. pmc Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation
    Ayako Watanabe
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 286:10702-11. 2011
    ..Here, we show that the cytoplasmic lipid raft protein, Raftlin, is essential for poly(I:C) cellular uptake in human myeloid dendritic cells and epithelial cells...
  29. doi The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae
    Hailong Cao
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, People s Republic of China
    Appl Microbiol Biotechnol 89:733-8. 2011
    The zinc finger proteins Mig1 and Mig2 play important roles in glucose repression of Saccharomyces cerevisiae...
  30. ncbi Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..The genes HMGCS2, FDPS, RAFTLIN, ACAD8, NPC2, and ABCG1 were associated with AD at a significance level of P < or = 0.05 in this sample...
  31. ncbi Multiple regulatory proteins mediate repression and activation by interaction with the yeast Mig1 binding site
    J Wu
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo 43699 0008, USA
    Yeast 14:985-1000. 1998
    ..Complete loss of repression was seen in a mig1 mig2 double mutant...
  32. pmc Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae
    L L Lutfiyya
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genetics 150:1377-91. 1998
    Mig1 and Mig2 are proteins with similar zinc fingers that are required for glucose repression of SUC2 expression. Mig1, but not Mig2, is required for repression of some other glucose-repressed genes, including the GAL genes...
  33. pmc Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation
    M Proft
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia CSIC, 46022 Valencia, Spain
    Mol Cell Biol 19:537-46. 1999
    ..Its function was abolished in a mig1 mig2 double-deletion strain as well as in either ssn6 or tup1 single mutants...
  34. ncbi Investigation of the impact of MIG1 and MIG2 on the physiology of Saccharomyces cerevisiae
    C J Klein
    Department of Biotechnology, Technical University of Denmark, Lyngby, Denmark
    J Biotechnol 68:197-212. 1999
    The gene functions of MIG1 and MIG2 are well known for their role in glucose control in Saccharomyces cerevisiae. A prototrophic mig1 disruptant (T468) and mig1mig2 double disruptant (T475) as well as their congenic wild-type strain (CEN...
  35. pmc NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae
    H Zhou
    Department of Genetics Harvard Medical School 200 Longwood Avenue Boston, MA 02115, USA
    BMC Genet 2:5. 2001
    ..of transcription in the yeast, Saccharomyces cerevisiae, has been shown to be controlled by several factors, including two repressors called Mig1 and Mig2. Past results suggest that other repressors may be involved in glucose repression.
  36. ncbi A maize-specifically expressed gene cluster in Ustilago maydis
    Christoph W Basse
    Institut für Genetik und Mikrobiologie der Universität München, D 80638 München, Germany
    Mol Microbiol 43:75-93. 2002
    ..We have identified the fungal mig2-1 gene as being specifically expressed during this biotrophic stage...
  37. pmc The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction
    Kazuko Saeki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 22:3015-26. 2003
    ..Among these raft proteins, we characterized a novel protein termed Raftlin (raft-linking protein)...
  38. ncbi Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Ann N Y Acad Sci 1011:284-98. 2004
    ..Among the known transcriptional factors, OPI1, MIG2, INO2, and ROX1 belonged to the upregulated genes, whereas MSN4, MBR1, ZMS1, ZAP1, TFC3, GAT1, ADR1, CAT8, and YAP4 ..
  39. ncbi A systems biology approach to study glucose repression in the yeast Saccharomyces cerevisiae
    Steen Lund Westergaard
    Center for Microbial Biotechnology, BioCentrum, Technical University of Denmark, Building 223, DK 2800 Kgs, Lyngby, Denmark
    Biotechnol Bioeng 96:134-45. 2007
    ..genome-wide transcription analysis of strains with disruption of HXK2, GRR1, MIG1, the combination of MIG1 and MIG2, and the parental strain, we identified 393 genes to have significantly changed expression levels...
  40. ncbi The transcriptional response of the yeast Na(+)-ATPase ENA1 gene to alkaline stress involves three main signaling pathways
    Maria Platara
    Department of Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    J Biol Chem 281:36632-42. 2006
    ..Cells lacking Mig1 or Mig2 repressors had a near wild type response, but the double mutant presented a high level of expression upon alkaline ..
  41. pmc A quantitative model of glucose signaling in yeast reveals an incoherent feed forward loop leading to a specific, transient pulse of transcription
    Sooraj Kuttykrishnan
    Center for Genome Sciences and Systems Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 107:16743-8. 2010
    ..for this result: HXT2-4 are governed by a type 2, incoherent feed forward regulatory loop involving the Rgt1 and Mig2 transcriptional repressors...
  42. ncbi Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells
    Amelie Avet-Rochex
    Commissariat a l Energie Atomique, DSV, iRTSV, 17 rue des Martyrs, Grenoble F 38054, France
    Genes Cells 12:1193-204. 2007
    ..Searching for the contribution of each RhoGTPases, Rho1, Rac1, Rac2, Mtl (Mig2-like) and Cdc42 to fly resistance to P. aeruginosa infections, we found that Rac2 is required to resist to P...
  43. doi Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades
    C J Carter
    Neurochem Int 52:920-34. 2008
    ..Viral uptake is cholesterol- and lipid raft-dependent (DHCR24, HMGCR, FDPS, RAFTLIN, SREBF1)...
  44. doi The Ustilago maydis Cys2His2-type zinc finger transcription factor Mzr1 regulates fungal gene expression during the biotrophic growth stage
    Yan Zheng
    Max Planck Institute for Terrestrial Microbiology, Department of Organismic Interactions, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Mol Microbiol 68:1450-70. 2008
    ..Expression of the U. maydis mig2 cluster genes is tightly linked to this phase...
  45. doi Nsf1/Ypl230w participates in transcriptional activation during non-fermentative growth and in response to salt stress in Saccharomyces cerevisiae
    Chris Hlynialuk
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada
    Microbiology 154:2482-91. 2008
    ..Different sets of transcription factors are needed to adjust to specific carbon conditions. For example, Mig1 and Mig2 repress the transcription of gluconeogenic and respiratory genes in the presence of abundant glucose, while the ..
  46. pmc Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3
    Jakub Orzechowski Westholm
    The Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 751 24 Uppsala, Sweden
    BMC Genomics 9:601. 2008
    ..The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3...
  47. pmc Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma
    Robert S Boyd
    Medical Research Council, University of Leicester, Leicester, United Kingdom
    Mol Cell Proteomics 8:1501-15. 2009
    ..been associated with lipid rafts, and shotgun proteomics/protein profiling revealed that key lipid raft proteins, raftlin (four of five patients) and CSK (C-terminal Src kinase)-binding protein (Cbp)/phosphoprotein associated with ..
  48. pmc Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression
    L L Lutfiyya
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:4790-7. 1996
    ..Overexpression of MIG2 represses SUC2 under nonrepressing conditions, and a LexA-Mig2p fusion represses transcription of a lexO-containing ..
  49. pmc Common body mass index-associated variants confer risk of extreme obesity
    Chris Cotsapas
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Mol Genet 18:3502-7. 2009
    ..Our results suggest that variants influencing BMI also contribute to severe obesity, a condition at the extreme of the phenotypic spectrum rather than a distinct condition...
  50. pmc Genome-wide association identifies ATOH7 as a major gene determining human optic disc size
    Stuart Macgregor
    Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mol Genet 19:2716-24. 2010
    ..5x10(-7), in the gene RFTN1. Direct sequencing of ATOH7 in 12 patients with optic nerve hypoplasia, one of the leading causes of blindness in ..

Research Grants5

  1. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2003
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  2. "Calling Cards" for DNA-binding proteins: A tool for their genome-wide mapping
    ROBI MITRA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. Mitochondria and Mutagenesis
    Keshav K Singh; Fiscal Year: 2010
    ..abstract_text> ..
  4. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  5. Loss of FLJ13639 Expression in Acute Leukemia
    Keshav K Singh; Fiscal Year: 2010
    ..Confirmation of the role of the loss of FLJ13639 in leukemia prognosis, increase of chemo resistance should lead us and others, to develop new prognostic tools as well as novel, innovative therapeutic strategies. ..