Genomes and Genes
Gene Symbol: RFC2
Description: replication factor C subunit 2
Alias: RFC40, replication factor C subunit 2, A1 40 kDa subunit, RF-C 40 kDa subunit, activator 1 subunit 2, replication factor C (activator 1) 2, 40kDa
Publications286 found, 100 shown here
- Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesisMalgorzata Nieborowska-Skorska
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Blood 99:4531-9. 2002..These data indicate that induction of A1 and pim-1 expression may play a critical role in the BCR/ABL-dependent transformation...
- Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymesTsukasa Kawahara
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
BMC Evol Biol 7:178. 2007....
- Anoikis in the cardiovascular system: known and unknown extracellular mediatorsJean Baptiste Michel
INSERM Unit 460, CHU Xavier Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
Arterioscler Thromb Vasc Biol 23:2146-54. 2003..However, the exact role of anoïkis in cardiovascular pathologies remains to be further defined...
- Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cellsEnzo Nisoli
Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
J Pathol 198:378-87. 2002..The study did not find any association between beta(3)-adrenoceptor gene polymorphism and noradrenergic signalling defects in MSL subjects with or without mitochondrial DNA mutations...
- Killing of spores of Bacillus subtilis by tert-butyl hydroperoxide plus a TAML activatorM Paul
Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 3305, USA
J Appl Microbiol 102:954-62. 2007....
- Fission yeast Rad17 associates with chromatin in response to aberrant genomic structuresM Kai
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
Mol Cell Biol 21:3289-301. 2001..Rad17 is able to complex in vivo with an Rfc small subunit, Rfc2, but not with Rfc1...
- Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulationJennifer R Crew
Department of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Exp Cell Res 316:1039-49. 2010....
- An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) geneYoshibumi Matsushima
Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
J Immunol 185:2340-9. 2010..This study demonstrates that the TRAF3IP2 protein plays an important role in AD and suggests the protein as a therapeutic target to treat AD...
- Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control geneH A Bluyssen
MGC Department of Cell Biology and Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands
Genomics 55:219-28. 1999..Our results suggest that the structure and function of the checkpoint "rad" genes in the G2/M checkpoint pathway are evolutionary conserved between yeast and higher eukaryotes...
- Reductive modification and nonreductive activation of purified spinach chloroplast NADP-dependent glyceraldehyde-3-phosphate dehydrogenaseE Baalmann
Fachbereich Biologie chemie, Universitat Osnabruck, Federal Republic of Germany
Arch Biochem Biophys 324:201-8. 1995....
- Identification of the first Oomycete annexin as a (1-->3)-beta-D-glucan synthase activatorJamel Bouzenzana
Equipe Organisation et Dynamique des Membranes Biologiques, UMR CNRS 5013, Bâtiment Chevreul, Université Lyon I, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
Mol Microbiol 62:552-65. 2006..The results, which are discussed in relation with the possible regulation mechanisms of (1-->3)-beta-D-glucan synthases, represent a first step towards a better understanding of cell wall polysaccharide biosynthesis in Oomycetes...
- (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domainC Loeb-Hennard
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
Biochemistry 39:11928-38. 2000..5% pyrenyl-PE) referable to nonspecific interaction of pyrenyl-PE with HH-Histag-BDH or GST-CTBDH. Thus, the 103-residue CTBDH constitutes a PC-selective lipid binding domain of the PC-requiring BDH...
- A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogsD R Abendschein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Pharmacol Exp Ther 296:567-72. 2001..2-fold, 11.5-fold, and 2.3-fold, respectively, for heparin/aspirin. Inhibition of FXa with ZK-807834 decreases reocclusion and improves patency of recanalized arteries without increasing bleeding compared with heparin/aspirin...
- Late results of catheter-directed recombinant tissue plasminogen activator fibrinolytic therapy of iliofemoral deep venous thrombosisIvan Benaduce Casella
Division of Vascular Surgery, Medical School, Sao Paulo University, Sao Paulo, SP, Brazil
Clinics (Sao Paulo) 62:31-40. 2007..To evaluate the efficacy of catheter-directed low-dose recombinant tissue-type plasminogen activator infusion in the treatment of iliofemoral deep venous thrombosis and prevention of post-thrombotic syndrome...
- Combined comparative and chemical proteomics on the mechanisms of levo-tetrahydropalmatine-induced antinociception in the formalin testChen Wang
Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai, People s Republic of China
J Proteome Res 9:3225-34. 2010....
- Determinants of brown adipocyte development and thermogenesisD Richard
Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, et Groupe interdisciplinaire de Recherche sur l Obésité de l Université Laval, Quebec, Canada
Int J Obes (Lond) 34:S59-66. 2010..This short review summarizes recent progress made in the biology of the brown fat cell and focuses on the determinants of the brown adipocyte development and activity...
- Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligasesP D Burbelo
Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 90:11543-7. 1993..The finding that the region required for the binding of murine A1 p145 to DNA has similarity to a domain found in DNA ligases suggests that this region may be utilized by both proteins in recognizing DNA...
- A GAL4-like protein is involved in the switch between biotrophic and necrotrophic phases of the infection process of Colletotrichum lindemuthianum on common bean. M Dufresne
Laboratoire de Phytopathologie Moléculaire, Centre de Recherche sur les Plantes, Universite Paris Sud, 91405 Orsay Cedex, France
Plant Cell 12:1579-90. 2000..This study demonstrates that CLTA1 is both a pathogenicity gene and a regulatory gene involved in the switch between biotrophy and necrotrophy of the infection process of a hemibiotrophic fungus...
- Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)Beena Vallanat
NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC 27711, USA
BMC Genomics 11:16. 2010..Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARalpha and the HS response mediated by HSF1...
- Calcium and small-conductance calcium-activated potassium channels in gonadotropin-releasing hormone neurons before, during, and after pubertyDaniel J Spergel
Section of Endocrinology, Department of Pediatrics, University of Chicago, Illinois 60637 1470, USA
Endocrinology 148:2383-90. 2007..g. increased membrane depolarization and subsequent activation of preexisting Ca(2+) channels after increased excitatory synaptic input...
- Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in ratsXin Li Ding
Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
Behav Brain Res 208:194-201. 2010..Our data suggested that the TRPV4-NO-cGMP-PKG pathway could be involved in CCD-induced thermal hyperalgesia...
- The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiaeV N Noskov
Department of Biochemistry and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
Mol Cell Biol 18:4914-23. 1998..The RFC2 gene encodes the third-largest subunit of the RF-C complex...
- Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormoneR E Weiss
Department of Medicine, Jr Mental Retardation Research Center, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
EMBO J 18:1900-4. 1999..It supports the hypothesis that a putative defect in the SRC-1 gene or another co-factor could be the cause of RTH in humans without mutations in the TR genes...
- Calmodulin-binding transcription activator 1 mediates auxin signaling and responds to stresses in ArabidopsisYael Galon
Department of Plant Sciences, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
Planta 232:165-78. 2010..Thus, CAMTA1 participates in auxin signaling and responds to abiotic stresses...
- Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptorE Kalkhoven
Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 17:232-43. 1998..Thus, SRC1 exists as functionally distinct isoforms which are likely to play different roles in ER-mediated transcription...
- The N- and C-termini of Elg1 contribute to the maintenance of genome stabilityMarta B Davidson
Department of Biochemistry and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
DNA Repair (Amst) 7:1221-32. 2008..Elg1 interacts with Rfc2-5, forming the third alternative RFC complex identified to date...
- Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonistsK Murakami
Central Research Laboratories, Kyorin Pharmaceutical Co, Ltd, 2399 1 Nogi machi, Shimotsuga gun, Tochigi 329 0114, Japan
Biochem J 353:231-8. 2001..Moreover, fatty-acyl-CoAs also markedly inhibited agonist-induced recruitment of SRC-1. These findings demonstrate that fatty-acyl-CoAs have a novel function in the signalling pathways of PPARalpha and PPARgamma...
- Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathwayT Naiki
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
Mol Cell Biol 21:5838-45. 2001..structurally related to subunits of the replication factor C (RFC) complex, and forms an RFC-related complex with Rfc2, Rfc3, Rfc4, and Rfc5...
- Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopyJack D Griffith
Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 277:15233-6. 2002..Therefore, our results demonstrate structural similarity between the checkpoint Rad complexes and the PCNA and RFC replication factors and thus provide further support for models proposing analogous functions for these complexes...
- The cardioprotective effect of wine on human blood chemistryDavid P van Velden
Department of Family Medicine and Primary Care, Faculty of Health Sciences, University of Stellenbosch, Tygerberg 7505, South Africa
Ann N Y Acad Sci 957:337-40. 2002..This study confirmed that moderate consumption of wine, red more than white, exerts cardioprotective effects through beneficial changes in lipid profiles and plasma total antioxidant status...
- Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responsesSusumu Itoh
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Biol Chem 278:3751-61. 2003..However, the TGF-beta-induced epithelial to mesenchymal transdifferentiation was found to require an intact L45 loop and is likely to be dependent on the Smad pathways...
- Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidasesRyu Takeya
Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Biol Chem 278:25234-46. 2003..Thus, the novel homologues p41nox and p51nox likely function together or in combination with a classical one, thereby activating the two Nox family oxidases...
- Cardiovascular issues in hypogonadism and testosterone therapyRidwan Shabsigh
Department of Urology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Am J Cardiol 96:67M-72M. 2005..Further research on the cardiovascular benefits and risks of testosterone is strongly recommended...
- Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performanceMatthew J Huentelman
Neurogenomics Division, The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, AZ 85004, USA
Hum Mol Genet 16:1469-77. 2007..Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory...
- The PP2A inhibitor SET regulates natural killer cell IFN-gamma productionRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
J Exp Med 204:2397-405. 2007..Thus, SET expression is essential for suppressing PP2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma...
- Epigenomic derangement of hepatic glucose metabolism by feeding of high fructose diet and its prevention by Rosiglitazone in ratsH Yadav
Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India
Dig Liver Dis 41:500-8. 2009..The high consumption of fructose leads to the increasing incidence of insulin resistance by several unknown mechanisms. Hepatic glucose metabolism may also be an important target of fructose-induced-metabolic alterations...
- Poly(ethylene glycol) carbodiimide coupling reagents for the biological and chemical functionalization of water-soluble nanoparticlesHongyan Shen
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
ACS Nano 3:915-23. 2009..These reagents do not cause precipitation even at high loading levels and can be used to efficiently functionalize carboxylic acid coated NPs...
- Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patientsJong Suk Park
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Acta Diabetol 47:113-8. 2010..035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients...
- Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1)John P Flaherty
New York College of Osteopathic Medicine of New York Institute of Technology, Old Westbury, New York, USA
Genesis 48:568-75. 2010..Through the thoughtful use of tissue-specific, Cre-expressing mouse strains, the Noxa1 conditional allele will offer insight into the roles of NOXA1 in the variety of tissues in which it is expressed...
- The PP2A inhibitor SET regulates granzyme B expression in human natural killer cellsRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, 460 West 12th Ave, Columbus, OH 43210, USA
Blood 117:2378-84. 2011..These data provide evidence that granzyme B gene expression and therefore human NK-cell cytotoxicity can be regulated by the PP2A-SET interplay...
- Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in ratsChao Wang
Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
Behav Brain Res 221:19-24. 2011..In conclusion, our data suggested that NF-κB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia...
- Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cellsAneta Novotna
Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 11, 783 71 Olomouc, Czech Republic
Eur J Pharmacol 669:45-50. 2011..Overall, the stable over-expression of HNF4α in HepG2 cells restores some of the hepatospecific functions, but it has a minor effect on the expression of xenobiotic-metabolizing enzymes and their regulators...
- Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signalingXiaoqin Luo
Department of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, People s Republic of China
Mol Cell Biochem 362:211-8. 2012..These data suggest that C3G exerts its antiproliferative effect on TNF-α-induced VSMCs proliferation through inhibiting STAT3 activation by attenuating NoxA1-derived ROS over production...
- Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitisMohit Raja Jain
Center for Advanced Proteomics Research and Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School Cancer Center, 205 S Orange Ave, Newark, New Jersey 07103, United States
J Proteome Res 11:1791-803. 2012..Therefore, we conclude that it is feasible to generate useful information from iTRAQ-based neuroproteomics analysis of archived FFPE tissues for studying neurological disease tissues...
- DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAsMichelle Badura
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 109:18767-72. 2012..breast cancer associated proteins 1, 2 (BRCA1/2), Poly-ADP ribose polymerase (PARP), replication factor c2-5 (Rfc2-5), ataxia telangiectasia mutated gene 1 (ATM), meiotic recombination protein 11 (MRE-11), and others]...
- Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patternsNoemi Boque
Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
Mol Nutr Food Res 57:1473-8. 2013..We propose that AP exerts the antiobesity effects through the regulation of genes involved in adipogenesis, lipolysis, and fatty acid oxidation, in a process that could be mediated in part by epigenetic mechanisms. ..
- The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptorKatrin Ganzenberg
Institute of Experimental and Clinical Pharmacology and Toxicology, Dept of Toxicology, Wilhelmstr 56, 72074 Tubingen, Germany
Toxicology 308:113-21. 2013..This suggests a β-catenin-dependent postnatal priming of hepatocytes during postnatal liver development, later affecting the proliferative response of adult animals to CAR-activating xenobiotics...
- Control of the human osteopontin promoter by ERRα in colorectal cancerSalah Boudjadi
Department of Medicine, Faculty of Medicine and Sciences of Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
Am J Pathol 183:266-76. 2013..These findings suggest an additional mechanism by which ERRα participates in the development and progression of colorectal cancer, further supporting the relevance of targeting ERRα with antagonists as anticancer agents...
- Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acidCathal McCarthy
School of Biomolecular and Biomedical Science, UCD Conway Institute, UCD, Dublin, Ireland
EMBO Mol Med 5:1443-57. 2013..Importantly, macrophage specific deletion of PGC-1α accelerated atherosclerosis in the LDLR(-/-) mouse in vivo. These novel data support a functional role for PGC-1α in atheroprotection. ..
- Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cellsZilong Liu
Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
PLoS ONE 9:e104247. 2014..This study might lead to potential therapeutic intervention to ameliorate alcohol-induced apoptosis and/or neurodegeneration by targeting PGC-1α. ..
- Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathwayJiayao Lin
Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, P R China
Mol Med Rep 12:3835-40. 2015..These results suggested that LRE is able to suppress lipid accumulation in HFD‑fed C57BL/6 mice via enhancement of the AMPK pathway...
- G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAYShuibang Wang
From the Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 290:19544-57. 2015..Thus, GPR40 and PPARγ can function as an integrated two-receptor signal transduction pathway, a finding with implications for rational drug development. ..
- Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional ActivatorsAngela A Baker
Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA
J Biochem Mol Toxicol 29:545-51. 2015..TCPOBOP and PCN increased Ces2 hydrolytic activity in an isoform-specific manner. Taken together, these data demonstrate that activation of CAR, PXR, and Nrf2 regulates not only Ces mRNA expression, but also isoform-specific activity. ..
- Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytesLídia Ambrus
DE MTA Lendület Cellular Physiology Research Group, Department of Physiology, Medical Faculty, University of Debrecen, Debrecen, Hungary
J Cell Mol Med 19:2771-9. 2015..Therefore, it is proposed that targeted manipulation of certain PKC isoforms might be beneficial in certain proteinuric kidney diseases with altered TRPC6 functions...
- Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retinaG Foureaux
Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Braz J Med Biol Res 48:1109-14. 2015..83±2.80 area%; P<0.05). Treatment with XNT did not alter the VEGF expression in HG animals (P>0.05). Altogether, these findings indicate that activation of ACE2 reduced the death of retinal ganglion cells by apoptosis in HG rats. ..
- Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain ComplexesYung Ting Kuo
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
PLoS ONE 10:e0143600. 2015..This pre-clinical in vivo study suggests that PQQ may provide a potent therapeutic benefit for the treatment of denervation-induced atrophy by activating PGC-1α and maintaining the mitochondrial ETC complex in skeletal muscles. ..
- Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1Gábor Sirokmány
Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary Momentum Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest 1094, Hungary
Free Radic Biol Med 97:204-11. 2016..Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1. ..
- Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle CellsMak Soon Lee
Department of Nutritional Science and Food Management, College of Science and Industry Convergence, Ewha Womans University, Seoul 03760, Korea
Prev Nutr Food Sci 21:317-322. 2016..These results suggest that EPA and DHA may modulate mitochondrial biogenesis, which was partially associated with increased mtDNA replication and PGC-1α gene expression in C2C12 muscle cells...
- SRC-1 localisation in lumbosacral spinal cord of male and female Wistar ratsRichard N Ranson
Cardiff School of Biosciences, Biomedical Sciences Building, Cardiff, UK
Neuroreport 14:1821-4. 2003..Dorsal horn labelling appeared similarly reduced suggesting a possible age-related down-regulation of the transcription mediated by steroid receptors in some spinal neurons...
- Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNAViola Ellison
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Biol 1:E33. 2003..Sequence similarities suggest the biochemical functions of an RSR (Rad17-Rfc2-Rfc3-Rfc4-Rfc5) complex and an RHR heterotrimer (Rad1-Hus1-Rad9) may be similar to that of RFC and PCNA, ..
- Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesisMihoko Kai
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Mutat Res 532:59-73. 2003..Checkpoint Rad9-Rad1-Hus1 (9-1-1) complex, which is loaded onto chromatin by the Rad17-Rfc2-5 checkpoint complex in response to replication perturbation, recruits DinB onto chromatin to generate the point ..
- Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liverJonathan M Maher
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
Drug Metab Dispos 33:956-62. 2005..Thus, these specific transcription factors are implicated in regulation of both drug metabolism and efflux transport...
- Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiaeGöran O Bylund
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri, USA
Methods Enzymol 409:1-11. 2006..These alternative clamp loaders contain the small Rfc2-5 subunits of RFC, but replace the large Rfc1 subunit by a pathway-specific alternative large subunit, Rad24 for ..
- A redox-silent analogue of tocotrienol inhibits hypoxic adaptation of lung cancer cellsKorehito Kashiwagi
Project for Complementary Factors, National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
Biochem Biophys Res Commun 365:875-81. 2008..Overall these results suggest that T3E suppresses hypoxia adaptation of A549 cells by the inhibition in hypoxia-induced activation of Src signaling...
- Long-term caloric restriction up-regulates PPAR gamma co-activator 1 alpha (PGC-1alpha) expression in miceHarmit S Ranhotra
Orphan Receptor Laboratory, Department of Biochemistry, St Edmund s College, Shillong 793 003, India
Indian J Biochem Biophys 47:272-7. 2010..Taken together, the up-regulation of PGC-1alpha expression might potentially support optimal energy metabolism and biochemical adaptation, necessary for maintaining energy homeostasis during long-term CR...
- Peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α and hypoxia induced factor-1α mediate neuro- and vascular protection by hypoxic preconditioning in vitroJia Zhao
Department of Neurology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, No 107 Yanjiangxi Road, Guangzhou, 510120, PR China
Brain Res 1447:1-8. 2012..The present study demonstrated that both PGC-1α and HIF-1α played crucial roles in hypoxic preconditioning in endothelial and neuronal cells...
- Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunctionTatiane M Murça
Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Regul Pept 177:107-15. 2012..These results indicate that activation of intrinsic cardiac ACE2 by oral XNT treatment protects the heart against diabetes-induced dysfunction through mechanisms involving ACE, ACE2, ERK1/2, AMPK-α and AMPK-β(1) modulations...
- AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscleBrennan K Smith
Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
J Physiol 591:1551-61. 2013..These data suggest that exercise causes translocation of PGC-1α preferentially to SS mitochondria in an AMPK-dependent manner...
- Vascular endothelial growth factor modulates voltage-gated Na(+) channel properties and depresses action potential firing in cultured rat hippocampal neuronsGuang Chun Sun
Department of Pharmacy, The Fifth People s Hospital of Shanghai, Fudan University, 801 He Qing Rd, Shanghai 200240, PR China
Biol Pharm Bull 36:548-55. 2013..In addition, the frequency of neuron firing evoked by current injection was reversibly depressed by VEGF. Therefore, our results suggest a potential role of VGSCs in the modulation of VEGF on neuronal excitability...
- Management of the aging risk factor for Parkinson's diseaseOliver T Phillipson
School of Medical Sciences, University of Bristol, University Walk, Bristol, UK Electronic address
Neurobiol Aging 35:847-57. 2014..In addition there are potential synergies to support a neurorestorative role via glial derived neurotrophic factor expression. ..
- Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyomaNicole M Fletcher
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Reprod Sci 21:1145-52. 2014..Fibroid cells are characterized by a unique NOX profile, which promotes a severe prooxidant state that may be responsible for their development. Targeting these subunits may be beneficial for future therapeutic interventions. ..
- CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expressionWeiyan Xie
Beijing Neurosurgical Institute, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
Int J Biol Sci 10:192-9. 2014..Our results suggest that increased CDK5-mediated VEGF expression might play a crucial role in the development of pituitary adenomas, and that roscovitine and other CDK5 inhibitors could be useful as anticancer agents. ..
- MicroRNA-23a mediates mitochondrial compromise in estrogen deficiency-induced concentric remodeling via targeting PGC-1αLu Yao Sun
Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province 150081, China
J Mol Cell Cardiol 75:1-11. 2014..Taken together, E2 deficiency may cause mitochondrial compromise through miR-23a-mediated PGC-1α downregulation, which may subsequently lead to the menopause-associated concentric remodeling. ..
- The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiaeV Noskov
Department of Genetics, Sankt Petersburg University, Sankt Petersburg, Russia
Nucleic Acids Res 22:1527-35. 1994..We have isolated a gene, RFC2, that appears to be a component of the yeast RF-C. The RFC2 gene is located on chromosome X of S...
- Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardiumS S Chim
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Cell Biochem 78:533-40. 2000..Here we report the down-regulated mRNA expression of the 40-kDa subunit of replication factor C (RFC p40 or RFC2), which is an essential processive factor for proliferating cellular nuclear antigen-dependent DNA replication ..
- Thrombin activatable fibrinolysis inhibitor (TAFI) does not inhibit in vitro thrombolysis by pharmacological concentrations of t-PAM Colucci
Department of Biomedical Sciences, University of Bari, Italy
Thromb Haemost 85:661-6. 2001..Our data indicate that, under our experimental conditions, clot lysis by pharmacological concentrations of t-PA is not influenced by TAFIa even after maximal activation of this procarboxy-peptidase...
- Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1K Tsukiyama-Kohara
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Nat Med 7:1128-32. 2001..These findings demonstrate that 4E-BP1 is a novel regulator of adipogenesis and metabolism in mammals...
- Presynaptic modulation of rat arterial chemoreceptor function by 5-HT: role of K+ channel inhibition via protein kinase CMin Zhang
Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
J Physiol 551:825-42. 2003....
- Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell lineC E Waters
Endocrine Sciences Research Group, 3 810 Stopford Building, Schools of Biological Sciences and Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
J Endocrinol 183:375-83. 2004....
- Caspase signalling in neuropathic and inflammatory pain in the ratElizabeth K Joseph
Department of Medicine, Division of Neuroscience and Biomedical Sciences Programme, NIH Pain Centre, Box 0440 C522, University of California, San Francisco, San Francisco, CA 94143, USA
Eur J Neurosci 20:2896-902. 2004..This suggests that these pathways are potential targets for novel pharmacological agents for the treatment of inflammatory as well as neuropathic pain...
- A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor Sp1 and elevated gene expressionTina Hummelshoj
Department of Clinical Immunology, University Hospital of Copenhagen Rigshospitalet, Blegdamsvej 9, DK2200 Copenhagen, N, Denmark
Mol Immunol 43:980-6. 2006....
- Mechanism of proliferating cell nuclear antigen clamp opening by replication factor CNina Y Yao
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Biol Chem 281:17528-39. 2006..The Rfc5 subunit is required to open PCNA. Consistent with this result, Rfc18.104.22.168 and Rfc2.5 subassemblies are capable of opening and unloading PCNA from circular DNA...
- Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetesSteven E Kahn
Department of Internal Medicine, Division of Metbolism, Endocrinology and Nurtrition, VA Puget Sound Health Care System, 151, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetes 55:2357-64. 2006..Further, for CRP and fibrinogen this relationship is determined by body adiposity and not by insulin sensitivity or glucose control...
- Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxideAaron David Smith
Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
Pharmacol Biochem Behav 86:103-12. 2007..Results of the present investigation support the role of cerebellar NO-GC signaling in alpha4beta2 nAChR subtype-mediated attenuation of delta9-THC ataxia...
- Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transportJay S Petrick
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Drug Metab Dispos 35:1806-15. 2007..Collectively, these studies illustrate the fact that some xenobiotic inducers may elicit their response through mechanisms involving transcription factor regulation...
- Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbitsSteven Idell
Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
Exp Lung Res 33:419-40. 2007..The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective...
- The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcriptionYukio Yamamoto
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Drug Metab Dispos 36:1189-93. 2008....
- IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16Shutao Xie
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 184:2289-96. 2010..These findings identify the signaling pathway regulated by IL-17 to contribute to the development of spontaneous germinal centers in autoimmune BXD2 mice...
- Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activationClare C Davies
Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Cell Biol 12:963-72. 2010..Thus RACO-1 is a co-activator that links c-Jun to growth factor signalling and is essential for AP-1 function in proliferation...
- Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibitionZdenek Dvorak
Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 11, 783 71 Olomouc, Czech Republic
Toxicol Lett 202:129-32. 2011..Apart from CYP3A4, azoles influence the expression and activity of others drug-metabolizing cytochromes P450...
- Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblastsJean Bastin
INSERM U747, Universite Paris Descartes, UFR Biomédicale des Saints Pères, 45, rue des Saints Pères, 75270 Paris Cedex 06, France
Hum Mol Genet 20:2048-57. 2011..These results show, for the first time, that RSV markedly induces mitochondrial FAO capacities in human fibroblasts, and provides the initial proof-of-concept that RSV might be efficient for correction of inherited FAO disorders...
- Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha gene expression increases above the lactate threshold in human skeletal muscleT Tobina
Fukuoka University, Fukuoka, Japan
J Sports Med Phys Fitness 51:683-8. 2011..Therefore, this study compared the effects of two different exercise intensities (above lactate threshold (LT) and below LT) with an equal amount of energy expenditure on PGC-1α gene expression in human skeletal muscle...
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesisPontus Boström
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 481:463-8. 2012..This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise...
- Activation of liver X receptor attenuates endothelin-1 expression in vascular endothelial cellsMin Gao
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China
Int J Biochem Cell Biol 44:2299-307. 2012..These results suggest that LXRs may serve as a novel molecular target for modulating ET-1 expression in VECs, and even for the treatment of ET-1-associated inflammatory diseases...
- Signal-dependent Elk-1 target genes involved in transcript processing and cell migrationAneta Kasza
Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland Electronic address
Biochim Biophys Acta 1829:1026-33. 2013..The broad range of function of these proteins illustrates the complex role of Elk-1 in the regulation of cancer and inflammation. ..
- Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsisAnne D Cherry
From the Departments of Anesthesiology, Medicine and Pathology, Duke University Medical Center, Durham, North Carolina 27710
J Biol Chem 289:41-52. 2014..By implication, exploitation of this axis could lead to new pharmacological interventions to improve the antioxidant defenses during oxidative stress-induced mitochondrial damage. ..
- Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesionsPhilip G Nijland
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Glia 62:1125-41. 2014....
- Genome-wide expression analysis of hereditary hyperplastic gingivitis in silver foxes (Vulpes vulpes) using canine microarraysJo Anna B J Clark
a Department of Biology, Memorial University of Newfoundland, St John s, NL A1B 3X9, Canada
Genome 57:449-57. 2014..We hypothesize that the putative mutation occurs upstream of RAS in the extracellular signal-regulated kinase component of MAPK signalling. ..
- Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship StudyLi Li Xu
Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
J Med Chem 58:5419-36. 2015..Our results provide a new chemotype as Nrf2-ARE activators which deserve further optimization with the aim to obtain active anti-inflammatory agents through Nrf2-ARE pathway. ..
- TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cellsE J Sohn
Asbestos Environmental Health Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University, Yangsan Hospital, Yangsan, Korea
Cell Mol Biol (Noisy-le-grand) . 2012..Together, our results suggest that TGF-β may suppress the transcriptional activity of the genes related to mitochondrial biogenesis or function. This mechanism may provide a novel insight into the understanding of fibrosis disease...
- Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathwaysT Shimomura
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
Mol Cell Biol 18:5485-91. 1998..The Rad24 protein, which is structurally related to the RFC subunits, interacts physically with RFC subunits Rfc2 and Rfc5 and cosediments with Rfc5...
- Ashraf Gorgey; Fiscal Year: 2016..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
- Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart FailureMargaret P Chandler; Fiscal Year: 2010....
- Zhen Yan; Fiscal Year: 2015....
- David W Walker; Fiscal Year: 2016....
- John P Thyfault; Fiscal Year: 2015..The outcomes will also if determine if increased hepatic mitochondrial content or increased hepatic fatty acid oxidation are effective therapeutic targets to prevent NAFLD or hepatic insulin resistance. ..
- Memory modulation by SK channelsROBERT WILLIAM STACKMAN; Fiscal Year: 2013..These studies will also contribute to defining targets for novel therapies to combat impairments of memory that result from aging and neurological disorders, a well as treatments for fear and anxiety disorders. ..
- Rita Marie Cowell; Fiscal Year: 2014..These studies will test whether transcriptional pathways that control mitochondrial function and calcium homeostasis in interneurons have potential as targets for treatment of patients with HD. ..
- LAURA XIAOFEI ROSE LIU; Fiscal Year: 2014..Such insights will provide novel avenues of therapeutic intervention against CVD. ..
- The role of establishment factors in cohesionJerard Hurwitz; Fiscal Year: 2010..will be studied;B) further characterize the in vitro properties of the establishment proteins Ctf18-Dcc1-Ctf8-RFC2-5 (a PCNA clamp loader), Ctf7p (a PCNA interacting protein and acetylase), ChlR1 p (a 5'-3'DNA helicase) ..
- DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIESLewis Becker; Fiscal Year: 2001..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
- REGULATION AND FUNCTION OF LUNG SPECIFIC FREAC GENESYe Shih Ho; Fiscal Year: 2002..abstract_text> ..
- Functional Analysis of PGC1-a holo-complex in DiabetesMarcus Cooper; Fiscal Year: 2009..Ultimately, the environment and the program will foster the development of the principal investigator into an independent physician-scientist. ..
- PGC-1 Co-Activators in Cardiac Metabolism and FunctionZoltan Arany; Fiscal Year: 2009..abstract_text> ..
- PRACTICAL SYNTHESES OF THE PHOSPHOINOSITIDESRAJINDRA ANEJA; Fiscal Year: 1990....
- Protective Mechanism of an Anti-Inflammatory Herbal MixAli Banan; Fiscal Year: 2006..abstract_text> ..
- FATTY ACID METABOLISM IN CARDIAC ISCHEMIADIANE HICKSON BICK; Fiscal Year: 2002..Location of a malonyl-CoA compartment that is inaccessible to CPT-I will shed light on the inconsistency between the high malonyl CoA content in heart and reliance on beta-oxidation. ..
- ISLET FUNCTION IN TYPE 2 DIABETESSteven Kahn; Fiscal Year: 2003..The applicant has successfully trained a number of young investigators in the areas of patient-oriented and basic research and a plan to continue doing so is presented. ..
- Non-traditional Cardiovascular Risk Factors in DM type 2Peter Reaven; Fiscal Year: 2004..Long- term (future) aims will include evaluating the prospective relationship of these novel cardiovascular risk factors to the progression of atherosclerosis and the development of macrovascular disease in this same population. ..
- CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASESteven Idell; Fiscal Year: 2004..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
- Thyroid Hormone Receptor Isoforms & Coactivators In VivoRoy Weiss; Fiscal Year: 2005..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
- Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytesYong Xiao Wang; Fiscal Year: 2010..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
- Plasminogen activators and cerebral ischemic injuryWilliam M Armstead; Fiscal Year: 2010....
- Novel Signaling for Ca2+ and Release in Airway MyocytesYong Xiao Wang; Fiscal Year: 2007..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
- Gene Expression in Prediabetes: Potential Role of PGC-1MARY PATTI; Fiscal Year: 2006..abstract_text> ..
- Heterogeneity of hypoxic Ca2+ release in pulmonary and *Yong Xiao Wang; Fiscal Year: 2006..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
- Reinstallation of functional p53 in glial tumors in vivoKsenya Shchors; Fiscal Year: 2006..Overall, the proposed research will significantly contribute to the understanding of gliomagenesis. ..
- EGF, Oxidants & Intestinal Barrier IntegrityAli Banan; Fiscal Year: 2006..abstract_text> ..
- POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAINWilliam Armstead; Fiscal Year: 2005..These studies may lead to therapies for brain injured children. ..
- The role of cardiolipin apoptosisDIANE HICKSON BICK; Fiscal Year: 2007..The role of these modified phospholipids in cyt c release will be determined. We will answer the question "is the loss of cyt c preceded by deacylation of CL?" [unreadable] [unreadable]..
- Nuclear cofactors in Human Thyroid DiseaseRoy Weiss; Fiscal Year: 2007..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..