RFC2

Summary

Gene Symbol: RFC2
Description: replication factor C subunit 2
Alias: RFC40, replication factor C subunit 2, A1 40 kDa subunit, RF-C 40 kDa subunit, activator 1 subunit 2, replication factor C (activator 1) 2, 40kDa
Species: human

Top Publications

  1. ncbi Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
    Malgorzata Nieborowska-Skorska
    Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Blood 99:4531-9. 2002
  2. pmc Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
    Tsukasa Kawahara
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Evol Biol 7:178. 2007
  3. ncbi Anoikis in the cardiovascular system: known and unknown extracellular mediators
    Jean Baptiste Michel
    INSERM Unit 460, CHU Xavier Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
    Arterioscler Thromb Vasc Biol 23:2146-54. 2003
  4. ncbi Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
    J Pathol 198:378-87. 2002
  5. ncbi Killing of spores of Bacillus subtilis by tert-butyl hydroperoxide plus a TAML activator
    M Paul
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 3305, USA
    J Appl Microbiol 102:954-62. 2007
  6. pmc Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures
    M Kai
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Mol Cell Biol 21:3289-301. 2001
  7. pmc Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulation
    Jennifer R Crew
    Department of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Cell Res 316:1039-49. 2010
  8. doi An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene
    Yoshibumi Matsushima
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    J Immunol 185:2340-9. 2010
  9. ncbi Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene
    H A Bluyssen
    MGC Department of Cell Biology and Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Genomics 55:219-28. 1999
  10. ncbi Reductive modification and nonreductive activation of purified spinach chloroplast NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
    E Baalmann
    Fachbereich Biologie chemie, Universitat Osnabruck, Federal Republic of Germany
    Arch Biochem Biophys 324:201-8. 1995

Research Grants

  1. Ashraf Gorgey; Fiscal Year: 2016
  2. Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart Failure
    Margaret P Chandler; Fiscal Year: 2010
  3. Zhen Yan; Fiscal Year: 2015
  4. David W Walker; Fiscal Year: 2016
  5. John P Thyfault; Fiscal Year: 2015
  6. Memory modulation by SK channels
    ROBERT WILLIAM STACKMAN; Fiscal Year: 2013
  7. Rita Marie Cowell; Fiscal Year: 2014
  8. LAURA XIAOFEI ROSE LIU; Fiscal Year: 2014
  9. The role of establishment factors in cohesion
    Jerard Hurwitz; Fiscal Year: 2010
  10. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001

Detail Information

Publications286 found, 100 shown here

  1. ncbi Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis
    Malgorzata Nieborowska-Skorska
    Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Blood 99:4531-9. 2002
    ..These data indicate that induction of A1 and pim-1 expression may play a critical role in the BCR/ABL-dependent transformation...
  2. pmc Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
    Tsukasa Kawahara
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Evol Biol 7:178. 2007
    ....
  3. ncbi Anoikis in the cardiovascular system: known and unknown extracellular mediators
    Jean Baptiste Michel
    INSERM Unit 460, CHU Xavier Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
    Arterioscler Thromb Vasc Biol 23:2146-54. 2003
    ..However, the exact role of anoïkis in cardiovascular pathologies remains to be further defined...
  4. ncbi Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
    J Pathol 198:378-87. 2002
    ..The study did not find any association between beta(3)-adrenoceptor gene polymorphism and noradrenergic signalling defects in MSL subjects with or without mitochondrial DNA mutations...
  5. ncbi Killing of spores of Bacillus subtilis by tert-butyl hydroperoxide plus a TAML activator
    M Paul
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030 3305, USA
    J Appl Microbiol 102:954-62. 2007
    ....
  6. pmc Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures
    M Kai
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Mol Cell Biol 21:3289-301. 2001
    ..Rad17 is able to complex in vivo with an Rfc small subunit, Rfc2, but not with Rfc1...
  7. pmc Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulation
    Jennifer R Crew
    Department of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Cell Res 316:1039-49. 2010
    ....
  8. doi An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene
    Yoshibumi Matsushima
    Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
    J Immunol 185:2340-9. 2010
    ..This study demonstrates that the TRAF3IP2 protein plays an important role in AD and suggests the protein as a therapeutic target to treat AD...
  9. ncbi Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene
    H A Bluyssen
    MGC Department of Cell Biology and Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Genomics 55:219-28. 1999
    ..Our results suggest that the structure and function of the checkpoint "rad" genes in the G2/M checkpoint pathway are evolutionary conserved between yeast and higher eukaryotes...
  10. ncbi Reductive modification and nonreductive activation of purified spinach chloroplast NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
    E Baalmann
    Fachbereich Biologie chemie, Universitat Osnabruck, Federal Republic of Germany
    Arch Biochem Biophys 324:201-8. 1995
    ....
  11. ncbi Identification of the first Oomycete annexin as a (1-->3)-beta-D-glucan synthase activator
    Jamel Bouzenzana
    Equipe Organisation et Dynamique des Membranes Biologiques, UMR CNRS 5013, Bâtiment Chevreul, Université Lyon I, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Mol Microbiol 62:552-65. 2006
    ..The results, which are discussed in relation with the possible regulation mechanisms of (1-->3)-beta-D-glucan synthases, represent a first step towards a better understanding of cell wall polysaccharide biosynthesis in Oomycetes...
  12. ncbi (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain
    C Loeb-Hennard
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochemistry 39:11928-38. 2000
    ..5% pyrenyl-PE) referable to nonspecific interaction of pyrenyl-PE with HH-Histag-BDH or GST-CTBDH. Thus, the 103-residue CTBDH constitutes a PC-selective lipid binding domain of the PC-requiring BDH...
  13. ncbi A novel synthetic inhibitor of factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs
    D R Abendschein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Pharmacol Exp Ther 296:567-72. 2001
    ..2-fold, 11.5-fold, and 2.3-fold, respectively, for heparin/aspirin. Inhibition of FXa with ZK-807834 decreases reocclusion and improves patency of recanalized arteries without increasing bleeding compared with heparin/aspirin...
  14. ncbi Late results of catheter-directed recombinant tissue plasminogen activator fibrinolytic therapy of iliofemoral deep venous thrombosis
    Ivan Benaduce Casella
    Division of Vascular Surgery, Medical School, Sao Paulo University, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:31-40. 2007
    ..To evaluate the efficacy of catheter-directed low-dose recombinant tissue-type plasminogen activator infusion in the treatment of iliofemoral deep venous thrombosis and prevention of post-thrombotic syndrome...
  15. doi Combined comparative and chemical proteomics on the mechanisms of levo-tetrahydropalmatine-induced antinociception in the formalin test
    Chen Wang
    Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai, People s Republic of China
    J Proteome Res 9:3225-34. 2010
    ....
  16. doi Determinants of brown adipocyte development and thermogenesis
    D Richard
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, et Groupe interdisciplinaire de Recherche sur l Obésité de l Université Laval, Quebec, Canada
    Int J Obes (Lond) 34:S59-66. 2010
    ..This short review summarizes recent progress made in the biology of the brown fat cell and focuses on the determinants of the brown adipocyte development and activity...
  17. pmc Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases
    P D Burbelo
    Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:11543-7. 1993
    ..The finding that the region required for the binding of murine A1 p145 to DNA has similarity to a domain found in DNA ligases suggests that this region may be utilized by both proteins in recognizing DNA...
  18. pmc A GAL4-like protein is involved in the switch between biotrophic and necrotrophic phases of the infection process of Colletotrichum lindemuthianum on common bean.
    M Dufresne
    Laboratoire de Phytopathologie Moléculaire, Centre de Recherche sur les Plantes, Universite Paris Sud, 91405 Orsay Cedex, France
    Plant Cell 12:1579-90. 2000
    ..This study demonstrates that CLTA1 is both a pathogenicity gene and a regulatory gene involved in the switch between biotrophy and necrotrophy of the infection process of a hemibiotrophic fungus...
  19. pmc Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)
    Beena Vallanat
    NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC 27711, USA
    BMC Genomics 11:16. 2010
    ..Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARalpha and the HS response mediated by HSF1...
  20. pmc Calcium and small-conductance calcium-activated potassium channels in gonadotropin-releasing hormone neurons before, during, and after puberty
    Daniel J Spergel
    Section of Endocrinology, Department of Pediatrics, University of Chicago, Illinois 60637 1470, USA
    Endocrinology 148:2383-90. 2007
    ..g. increased membrane depolarization and subsequent activation of preexisting Ca(2+) channels after increased excitatory synaptic input...
  21. doi Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Xin Li Ding
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 208:194-201. 2010
    ..Our data suggested that the TRPV4-NO-cGMP-PKG pathway could be involved in CCD-induced thermal hyperalgesia...
  22. pmc The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces cerevisiae
    V N Noskov
    Department of Biochemistry and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 18:4914-23. 1998
    ..The RFC2 gene encodes the third-largest subunit of the RF-C complex...
  23. pmc Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone
    R E Weiss
    Department of Medicine, Jr Mental Retardation Research Center, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    EMBO J 18:1900-4. 1999
    ..It supports the hypothesis that a putative defect in the SRC-1 gene or another co-factor could be the cause of RTH in humans without mutations in the TR genes...
  24. doi Calmodulin-binding transcription activator 1 mediates auxin signaling and responds to stresses in Arabidopsis
    Yael Galon
    Department of Plant Sciences, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Planta 232:165-78. 2010
    ..Thus, CAMTA1 participates in auxin signaling and responds to abiotic stresses...
  25. pmc Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
    E Kalkhoven
    Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 17:232-43. 1998
    ..Thus, SRC1 exists as functionally distinct isoforms which are likely to play different roles in ER-mediated transcription...
  26. doi The N- and C-termini of Elg1 contribute to the maintenance of genome stability
    Marta B Davidson
    Department of Biochemistry and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
    DNA Repair (Amst) 7:1221-32. 2008
    ..Elg1 interacts with Rfc2-5, forming the third alternative RFC complex identified to date...
  27. pmc Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists
    K Murakami
    Central Research Laboratories, Kyorin Pharmaceutical Co, Ltd, 2399 1 Nogi machi, Shimotsuga gun, Tochigi 329 0114, Japan
    Biochem J 353:231-8. 2001
    ..Moreover, fatty-acyl-CoAs also markedly inhibited agonist-induced recruitment of SRC-1. These findings demonstrate that fatty-acyl-CoAs have a novel function in the signalling pathways of PPARalpha and PPARgamma...
  28. pmc Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway
    T Naiki
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 21:5838-45. 2001
    ..structurally related to subunits of the replication factor C (RFC) complex, and forms an RFC-related complex with Rfc2, Rfc3, Rfc4, and Rfc5...
  29. ncbi Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy
    Jack D Griffith
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:15233-6. 2002
    ..Therefore, our results demonstrate structural similarity between the checkpoint Rad complexes and the PCNA and RFC replication factors and thus provide further support for models proposing analogous functions for these complexes...
  30. ncbi The cardioprotective effect of wine on human blood chemistry
    David P van Velden
    Department of Family Medicine and Primary Care, Faculty of Health Sciences, University of Stellenbosch, Tygerberg 7505, South Africa
    Ann N Y Acad Sci 957:337-40. 2002
    ..This study confirmed that moderate consumption of wine, red more than white, exerts cardioprotective effects through beneficial changes in lipid profiles and plasma total antioxidant status...
  31. ncbi Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
    Susumu Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:3751-61. 2003
    ..However, the TGF-beta-induced epithelial to mesenchymal transdifferentiation was found to require an intact L45 loop and is likely to be dependent on the Smad pathways...
  32. ncbi Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:25234-46. 2003
    ..Thus, the novel homologues p41nox and p51nox likely function together or in combination with a classical one, thereby activating the two Nox family oxidases...
  33. ncbi Cardiovascular issues in hypogonadism and testosterone therapy
    Ridwan Shabsigh
    Department of Urology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Am J Cardiol 96:67M-72M. 2005
    ..Further research on the cardiovascular benefits and risks of testosterone is strongly recommended...
  34. ncbi Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance
    Matthew J Huentelman
    Neurogenomics Division, The Translational Genomics Research Institute, 445 N Fifth Street, Phoenix, AZ 85004, USA
    Hum Mol Genet 16:1469-77. 2007
    ..Our validated genomic and functional biological findings described herein suggest a role for CAMTA1 in human episodic memory...
  35. pmc The PP2A inhibitor SET regulates natural killer cell IFN-gamma production
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 204:2397-405. 2007
    ..Thus, SET expression is essential for suppressing PP2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma...
  36. doi Epigenomic derangement of hepatic glucose metabolism by feeding of high fructose diet and its prevention by Rosiglitazone in rats
    H Yadav
    Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India
    Dig Liver Dis 41:500-8. 2009
    ..The high consumption of fructose leads to the increasing incidence of insulin resistance by several unknown mechanisms. Hepatic glucose metabolism may also be an important target of fructose-induced-metabolic alterations...
  37. doi Poly(ethylene glycol) carbodiimide coupling reagents for the biological and chemical functionalization of water-soluble nanoparticles
    Hongyan Shen
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    ACS Nano 3:915-23. 2009
    ..These reagents do not cause precipitation even at high loading levels and can be used to efficiently functionalize carboxylic acid coated NPs...
  38. doi Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients
    Jong Suk Park
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Acta Diabetol 47:113-8. 2010
    ..035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients...
  39. pmc Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1)
    John P Flaherty
    New York College of Osteopathic Medicine of New York Institute of Technology, Old Westbury, New York, USA
    Genesis 48:568-75. 2010
    ..Through the thoughtful use of tissue-specific, Cre-expressing mouse strains, the Noxa1 conditional allele will offer insight into the roles of NOXA1 in the variety of tissues in which it is expressed...
  40. pmc The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, 460 West 12th Ave, Columbus, OH 43210, USA
    Blood 117:2378-84. 2011
    ..These data provide evidence that granzyme B gene expression and therefore human NK-cell cytotoxicity can be regulated by the PP2A-SET interplay...
  41. doi Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Chao Wang
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 221:19-24. 2011
    ..In conclusion, our data suggested that NF-κB could be involved in TRPV4-NO pathway in CCD-induced thermal hyperalgesia...
  42. doi Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells
    Aneta Novotna
    Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 11, 783 71 Olomouc, Czech Republic
    Eur J Pharmacol 669:45-50. 2011
    ..Overall, the stable over-expression of HNF4α in HepG2 cells restores some of the hepatospecific functions, but it has a minor effect on the expression of xenobiotic-metabolizing enzymes and their regulators...
  43. doi Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling
    Xiaoqin Luo
    Department of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Cell Biochem 362:211-8. 2012
    ..These data suggest that C3G exerts its antiproliferative effect on TNF-α-induced VSMCs proliferation through inhibiting STAT3 activation by attenuating NoxA1-derived ROS over production...
  44. pmc Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis
    Mohit Raja Jain
    Center for Advanced Proteomics Research and Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School Cancer Center, 205 S Orange Ave, Newark, New Jersey 07103, United States
    J Proteome Res 11:1791-803. 2012
    ..Therefore, we conclude that it is feasible to generate useful information from iTRAQ-based neuroproteomics analysis of archived FFPE tissues for studying neurological disease tissues...
  45. pmc DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs
    Michelle Badura
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 109:18767-72. 2012
    ..breast cancer associated proteins 1, 2 (BRCA1/2), Poly-ADP ribose polymerase (PARP), replication factor c2-5 (Rfc2-5), ataxia telangiectasia mutated gene 1 (ATM), meiotic recombination protein 11 (MRE-11), and others]...
  46. doi Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns
    Noemi Boque
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 57:1473-8. 2013
    ..We propose that AP exerts the antiobesity effects through the regulation of genes involved in adipogenesis, lipolysis, and fatty acid oxidation, in a process that could be mediated in part by epigenetic mechanisms. ..
  47. doi The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor
    Katrin Ganzenberg
    Institute of Experimental and Clinical Pharmacology and Toxicology, Dept of Toxicology, Wilhelmstr 56, 72074 Tubingen, Germany
    Toxicology 308:113-21. 2013
    ..This suggests a β-catenin-dependent postnatal priming of hepatocytes during postnatal liver development, later affecting the proliferative response of adult animals to CAR-activating xenobiotics...
  48. doi Control of the human osteopontin promoter by ERRα in colorectal cancer
    Salah Boudjadi
    Department of Medicine, Faculty of Medicine and Sciences of Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Pathol 183:266-76. 2013
    ..These findings suggest an additional mechanism by which ERRα participates in the development and progression of colorectal cancer, further supporting the relevance of targeting ERRα with antagonists as anticancer agents...
  49. pmc Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid
    Cathal McCarthy
    School of Biomolecular and Biomedical Science, UCD Conway Institute, UCD, Dublin, Ireland
    EMBO Mol Med 5:1443-57. 2013
    ..Importantly, macrophage specific deletion of PGC-1α accelerated atherosclerosis in the LDLR(-/-) mouse in vivo. These novel data support a functional role for PGC-1α in atheroprotection. ..
  50. pmc Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells
    Zilong Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 9:e104247. 2014
    ..This study might lead to potential therapeutic intervention to ameliorate alcohol-induced apoptosis and/or neurodegeneration by targeting PGC-1α. ..
  51. doi Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway
    Jiayao Lin
    Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, P R China
    Mol Med Rep 12:3835-40. 2015
    ..These results suggested that LRE is able to suppress lipid accumulation in HFD‑fed C57BL/6 mice via enhancement of the AMPK pathway...
  52. pmc G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY
    Shuibang Wang
    From the Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 290:19544-57. 2015
    ..Thus, GPR40 and PPARγ can function as an integrated two-receptor signal transduction pathway, a finding with implications for rational drug development. ..
  53. pmc Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators
    Angela A Baker
    Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA
    J Biochem Mol Toxicol 29:545-51. 2015
    ..TCPOBOP and PCN increased Ces2 hydrolytic activity in an isoform-specific manner. Taken together, these data demonstrate that activation of CAR, PXR, and Nrf2 regulates not only Ces mRNA expression, but also isoform-specific activity. ..
  54. pmc Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes
    Lídia Ambrus
    DE MTA Lendület Cellular Physiology Research Group, Department of Physiology, Medical Faculty, University of Debrecen, Debrecen, Hungary
    J Cell Mol Med 19:2771-9. 2015
    ..Therefore, it is proposed that targeted manipulation of certain PKC isoforms might be beneficial in certain proteinuric kidney diseases with altered TRPC6 functions...
  55. pmc Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina
    G Foureaux
    Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Braz J Med Biol Res 48:1109-14. 2015
    ..83±2.80 area%; P<0.05). Treatment with XNT did not alter the VEGF expression in HG animals (P>0.05). Altogether, these findings indicate that activation of ACE2 reduced the death of retinal ganglion cells by apoptosis in HG rats. ..
  56. pmc Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes
    Yung Ting Kuo
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 10:e0143600. 2015
    ..This pre-clinical in vivo study suggests that PQQ may provide a potent therapeutic benefit for the treatment of denervation-induced atrophy by activating PGC-1α and maintaining the mitochondrial ETC complex in skeletal muscles. ..
  57. doi Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1
    Gábor Sirokmány
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary Momentum Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest 1094, Hungary
    Free Radic Biol Med 97:204-11. 2016
    ..Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1. ..
  58. pmc Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle Cells
    Mak Soon Lee
    Department of Nutritional Science and Food Management, College of Science and Industry Convergence, Ewha Womans University, Seoul 03760, Korea
    Prev Nutr Food Sci 21:317-322. 2016
    ..These results suggest that EPA and DHA may modulate mitochondrial biogenesis, which was partially associated with increased mtDNA replication and PGC-1α gene expression in C2C12 muscle cells...
  59. ncbi SRC-1 localisation in lumbosacral spinal cord of male and female Wistar rats
    Richard N Ranson
    Cardiff School of Biosciences, Biomedical Sciences Building, Cardiff, UK
    Neuroreport 14:1821-4. 2003
    ..Dorsal horn labelling appeared similarly reduced suggesting a possible age-related down-regulation of the transcription mediated by steroid receptors in some spinal neurons...
  60. pmc Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA
    Viola Ellison
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 1:E33. 2003
    ..Sequence similarities suggest the biochemical functions of an RSR (Rad17-Rfc2-Rfc3-Rfc4-Rfc5) complex and an RHR heterotrimer (Rad1-Hus1-Rad9) may be similar to that of RFC and PCNA, ..
  61. ncbi Checkpoint responses to replication stalling: inducing tolerance and preventing mutagenesis
    Mihoko Kai
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Mutat Res 532:59-73. 2003
    ..Checkpoint Rad9-Rad1-Hus1 (9-1-1) complex, which is loaded onto chromatin by the Rad17-Rfc2-5 checkpoint complex in response to replication perturbation, recruits DinB onto chromatin to generate the point ..
  62. ncbi Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 33:956-62. 2005
    ..Thus, these specific transcription factors are implicated in regulation of both drug metabolism and efflux transport...
  63. ncbi Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae
    Göran O Bylund
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri, USA
    Methods Enzymol 409:1-11. 2006
    ..These alternative clamp loaders contain the small Rfc2-5 subunits of RFC, but replace the large Rfc1 subunit by a pathway-specific alternative large subunit, Rad24 for ..
  64. ncbi A redox-silent analogue of tocotrienol inhibits hypoxic adaptation of lung cancer cells
    Korehito Kashiwagi
    Project for Complementary Factors, National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
    Biochem Biophys Res Commun 365:875-81. 2008
    ..Overall these results suggest that T3E suppresses hypoxia adaptation of A549 cells by the inhibition in hypoxia-induced activation of Src signaling...
  65. ncbi Long-term caloric restriction up-regulates PPAR gamma co-activator 1 alpha (PGC-1alpha) expression in mice
    Harmit S Ranhotra
    Orphan Receptor Laboratory, Department of Biochemistry, St Edmund s College, Shillong 793 003, India
    Indian J Biochem Biophys 47:272-7. 2010
    ..Taken together, the up-regulation of PGC-1alpha expression might potentially support optimal energy metabolism and biochemical adaptation, necessary for maintaining energy homeostasis during long-term CR...
  66. doi Peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α and hypoxia induced factor-1α mediate neuro- and vascular protection by hypoxic preconditioning in vitro
    Jia Zhao
    Department of Neurology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, No 107 Yanjiangxi Road, Guangzhou, 510120, PR China
    Brain Res 1447:1-8. 2012
    ..The present study demonstrated that both PGC-1α and HIF-1α played crucial roles in hypoxic preconditioning in endothelial and neuronal cells...
  67. pmc Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction
    Tatiane M Murça
    Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Regul Pept 177:107-15. 2012
    ..These results indicate that activation of intrinsic cardiac ACE2 by oral XNT treatment protects the heart against diabetes-induced dysfunction through mechanisms involving ACE, ACE2, ERK1/2, AMPK-α and AMPK-β(1) modulations...
  68. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
    ..These data suggest that exercise causes translocation of PGC-1α preferentially to SS mitochondria in an AMPK-dependent manner...
  69. ncbi Vascular endothelial growth factor modulates voltage-gated Na(+) channel properties and depresses action potential firing in cultured rat hippocampal neurons
    Guang Chun Sun
    Department of Pharmacy, The Fifth People s Hospital of Shanghai, Fudan University, 801 He Qing Rd, Shanghai 200240, PR China
    Biol Pharm Bull 36:548-55. 2013
    ..In addition, the frequency of neuron firing evoked by current injection was reversibly depressed by VEGF. Therefore, our results suggest a potential role of VGSCs in the modulation of VEGF on neuronal excitability...
  70. doi Management of the aging risk factor for Parkinson's disease
    Oliver T Phillipson
    School of Medical Sciences, University of Bristol, University Walk, Bristol, UK Electronic address
    Neurobiol Aging 35:847-57. 2014
    ..In addition there are potential synergies to support a neurorestorative role via glial derived neurotrophic factor expression. ..
  71. doi Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma
    Nicole M Fletcher
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    Reprod Sci 21:1145-52. 2014
    ..Fibroid cells are characterized by a unique NOX profile, which promotes a severe prooxidant state that may be responsible for their development. Targeting these subunits may be beneficial for future therapeutic interventions. ..
  72. pmc CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression
    Weiyan Xie
    Beijing Neurosurgical Institute, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    Int J Biol Sci 10:192-9. 2014
    ..Our results suggest that increased CDK5-mediated VEGF expression might play a crucial role in the development of pituitary adenomas, and that roscovitine and other CDK5 inhibitors could be useful as anticancer agents. ..
  73. doi MicroRNA-23a mediates mitochondrial compromise in estrogen deficiency-induced concentric remodeling via targeting PGC-1α
    Lu Yao Sun
    Department of Pharmacology, Harbin Medical University the State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin, Heilongjiang Province 150081, China
    J Mol Cell Cardiol 75:1-11. 2014
    ..Taken together, E2 deficiency may cause mitochondrial compromise through miR-23a-mediated PGC-1α downregulation, which may subsequently lead to the menopause-associated concentric remodeling. ..
  74. pmc The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiae
    V Noskov
    Department of Genetics, Sankt Petersburg University, Sankt Petersburg, Russia
    Nucleic Acids Res 22:1527-35. 1994
    ..We have isolated a gene, RFC2, that appears to be a component of the yeast RF-C. The RFC2 gene is located on chromosome X of S...
  75. ncbi Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium
    S S Chim
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Cell Biochem 78:533-40. 2000
    ..Here we report the down-regulated mRNA expression of the 40-kDa subunit of replication factor C (RFC p40 or RFC2), which is an essential processive factor for proliferating cellular nuclear antigen-dependent DNA replication ..
  76. ncbi Thrombin activatable fibrinolysis inhibitor (TAFI) does not inhibit in vitro thrombolysis by pharmacological concentrations of t-PA
    M Colucci
    Department of Biomedical Sciences, University of Bari, Italy
    Thromb Haemost 85:661-6. 2001
    ..Our data indicate that, under our experimental conditions, clot lysis by pharmacological concentrations of t-PA is not influenced by TAFIa even after maximal activation of this procarboxy-peptidase...
  77. ncbi Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
    K Tsukiyama-Kohara
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Nat Med 7:1128-32. 2001
    ..These findings demonstrate that 4E-BP1 is a novel regulator of adipogenesis and metabolism in mammals...
  78. pmc Presynaptic modulation of rat arterial chemoreceptor function by 5-HT: role of K+ channel inhibition via protein kinase C
    Min Zhang
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 551:825-42. 2003
    ....
  79. ncbi Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell line
    C E Waters
    Endocrine Sciences Research Group, 3 810 Stopford Building, Schools of Biological Sciences and Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Endocrinol 183:375-83. 2004
    ....
  80. ncbi Caspase signalling in neuropathic and inflammatory pain in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Programme, NIH Pain Centre, Box 0440 C522, University of California, San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 20:2896-902. 2004
    ..This suggests that these pathways are potential targets for novel pharmacological agents for the treatment of inflammatory as well as neuropathic pain...
  81. ncbi A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor Sp1 and elevated gene expression
    Tina Hummelshoj
    Department of Clinical Immunology, University Hospital of Copenhagen Rigshospitalet, Blegdamsvej 9, DK2200 Copenhagen, N, Denmark
    Mol Immunol 43:980-6. 2006
    ....
  82. ncbi Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C
    Nina Y Yao
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 281:17528-39. 2006
    ..The Rfc5 subunit is required to open PCNA. Consistent with this result, Rfc2.3.4.5 and Rfc2.5 subassemblies are capable of opening and unloading PCNA from circular DNA...
  83. ncbi Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes
    Steven E Kahn
    Department of Internal Medicine, Division of Metbolism, Endocrinology and Nurtrition, VA Puget Sound Health Care System, 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:2357-64. 2006
    ..Further, for CRP and fibrinogen this relationship is determined by body adiposity and not by insulin sensitivity or glucose control...
  84. ncbi Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide
    Aaron David Smith
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Pharmacol Biochem Behav 86:103-12. 2007
    ..Results of the present investigation support the role of cerebellar NO-GC signaling in alpha4beta2 nAChR subtype-mediated attenuation of delta9-THC ataxia...
  85. ncbi Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport
    Jay S Petrick
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Drug Metab Dispos 35:1806-15. 2007
    ..Collectively, these studies illustrate the fact that some xenobiotic inducers may elicit their response through mechanisms involving transcription factor regulation...
  86. ncbi Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits
    Steven Idell
    Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Exp Lung Res 33:419-40. 2007
    ..The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective...
  87. pmc The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription
    Yukio Yamamoto
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 36:1189-93. 2008
    ....
  88. pmc IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16
    Shutao Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:2289-96. 2010
    ..These findings identify the signaling pathway regulated by IL-17 to contribute to the development of spontaneous germinal centers in autoimmune BXD2 mice...
  89. doi Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation
    Clare C Davies
    Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 12:963-72. 2010
    ..Thus RACO-1 is a co-activator that links c-Jun to growth factor signalling and is essential for AP-1 function in proliferation...
  90. doi Drug-drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition
    Zdenek Dvorak
    Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 11, 783 71 Olomouc, Czech Republic
    Toxicol Lett 202:129-32. 2011
    ..Apart from CYP3A4, azoles influence the expression and activity of others drug-metabolizing cytochromes P450...
  91. doi Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblasts
    Jean Bastin
    INSERM U747, Universite Paris Descartes, UFR Biomédicale des Saints Pères, 45, rue des Saints Pères, 75270 Paris Cedex 06, France
    Hum Mol Genet 20:2048-57. 2011
    ..These results show, for the first time, that RSV markedly induces mitochondrial FAO capacities in human fibroblasts, and provides the initial proof-of-concept that RSV might be efficient for correction of inherited FAO disorders...
  92. ncbi Peroxisomal proliferator-activated receptor gamma co-activator-1 alpha gene expression increases above the lactate threshold in human skeletal muscle
    T Tobina
    Fukuoka University, Fukuoka, Japan
    J Sports Med Phys Fitness 51:683-8. 2011
    ..Therefore, this study compared the effects of two different exercise intensities (above lactate threshold (LT) and below LT) with an equal amount of energy expenditure on PGC-1α gene expression in human skeletal muscle...
  93. pmc A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    Pontus Boström
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 481:463-8. 2012
    ..This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise...
  94. doi Activation of liver X receptor attenuates endothelin-1 expression in vascular endothelial cells
    Min Gao
    Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China
    Int J Biochem Cell Biol 44:2299-307. 2012
    ..These results suggest that LXRs may serve as a novel molecular target for modulating ET-1 expression in VECs, and even for the treatment of ET-1-associated inflammatory diseases...
  95. doi Signal-dependent Elk-1 target genes involved in transcript processing and cell migration
    Aneta Kasza
    Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland Electronic address
    Biochim Biophys Acta 1829:1026-33. 2013
    ..The broad range of function of these proteins illustrates the complex role of Elk-1 in the regulation of cancer and inflammation. ..
  96. pmc Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis
    Anne D Cherry
    From the Departments of Anesthesiology, Medicine and Pathology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 289:41-52. 2014
    ..By implication, exploitation of this axis could lead to new pharmacological interventions to improve the antioxidant defenses during oxidative stress-induced mitochondrial damage. ..
  97. doi Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
    Philip G Nijland
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 62:1125-41. 2014
    ....
  98. doi Genome-wide expression analysis of hereditary hyperplastic gingivitis in silver foxes (Vulpes vulpes) using canine microarrays
    Jo Anna B J Clark
    a Department of Biology, Memorial University of Newfoundland, St John s, NL A1B 3X9, Canada
    Genome 57:449-57. 2014
    ..We hypothesize that the putative mutation occurs upstream of RAS in the extracellular signal-regulated kinase component of MAPK signalling. ..
  99. doi Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study
    Li Li Xu
    Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
    J Med Chem 58:5419-36. 2015
    ..Our results provide a new chemotype as Nrf2-ARE activators which deserve further optimization with the aim to obtain active anti-inflammatory agents through Nrf2-ARE pathway. ..
  100. ncbi TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cells
    E J Sohn
    Asbestos Environmental Health Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University, Yangsan Hospital, Yangsan, Korea
    Cell Mol Biol (Noisy-le-grand) . 2012
    ..Together, our results suggest that TGF-β may suppress the transcriptional activity of the genes related to mitochondrial biogenesis or function. This mechanism may provide a novel insight into the understanding of fibrosis disease...
  101. pmc Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways
    T Shimomura
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 0814, Japan
    Mol Cell Biol 18:5485-91. 1998
    ..The Rad24 protein, which is structurally related to the RFC subunits, interacts physically with RFC subunits Rfc2 and Rfc5 and cosediments with Rfc5...

Research Grants30

  1. Ashraf Gorgey; Fiscal Year: 2016
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  2. Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart Failure
    Margaret P Chandler; Fiscal Year: 2010
    ....
  3. Zhen Yan; Fiscal Year: 2015
    ....
  4. David W Walker; Fiscal Year: 2016
    ....
  5. John P Thyfault; Fiscal Year: 2015
    ..The outcomes will also if determine if increased hepatic mitochondrial content or increased hepatic fatty acid oxidation are effective therapeutic targets to prevent NAFLD or hepatic insulin resistance. ..
  6. Memory modulation by SK channels
    ROBERT WILLIAM STACKMAN; Fiscal Year: 2013
    ..These studies will also contribute to defining targets for novel therapies to combat impairments of memory that result from aging and neurological disorders, a well as treatments for fear and anxiety disorders. ..
  7. Rita Marie Cowell; Fiscal Year: 2014
    ..These studies will test whether transcriptional pathways that control mitochondrial function and calcium homeostasis in interneurons have potential as targets for treatment of patients with HD. ..
  8. LAURA XIAOFEI ROSE LIU; Fiscal Year: 2014
    ..Such insights will provide novel avenues of therapeutic intervention against CVD. ..
  9. The role of establishment factors in cohesion
    Jerard Hurwitz; Fiscal Year: 2010
    ..will be studied;B) further characterize the in vitro properties of the establishment proteins Ctf18-Dcc1-Ctf8-RFC2-5 (a PCNA clamp loader), Ctf7p (a PCNA interacting protein and acetylase), ChlR1 p (a 5'-3'DNA helicase) ..
  10. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
    ..This study will provide important insights into the phenotypic and genetic determinants of clinical and occult CHD in families with premature CHD. ..
  11. REGULATION AND FUNCTION OF LUNG SPECIFIC FREAC GENES
    Ye Shih Ho; Fiscal Year: 2002
    ..abstract_text> ..
  12. Functional Analysis of PGC1-a holo-complex in Diabetes
    Marcus Cooper; Fiscal Year: 2009
    ..Ultimately, the environment and the program will foster the development of the principal investigator into an independent physician-scientist. ..
  13. PGC-1 Co-Activators in Cardiac Metabolism and Function
    Zoltan Arany; Fiscal Year: 2009
    ..abstract_text> ..
  14. PRACTICAL SYNTHESES OF THE PHOSPHOINOSITIDES
    RAJINDRA ANEJA; Fiscal Year: 1990
    ....
  15. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  16. FATTY ACID METABOLISM IN CARDIAC ISCHEMIA
    DIANE HICKSON BICK; Fiscal Year: 2002
    ..Location of a malonyl-CoA compartment that is inaccessible to CPT-I will shed light on the inconsistency between the high malonyl CoA content in heart and reliance on beta-oxidation. ..
  17. ISLET FUNCTION IN TYPE 2 DIABETES
    Steven Kahn; Fiscal Year: 2003
    ..The applicant has successfully trained a number of young investigators in the areas of patient-oriented and basic research and a plan to continue doing so is presented. ..
  18. Non-traditional Cardiovascular Risk Factors in DM type 2
    Peter Reaven; Fiscal Year: 2004
    ..Long- term (future) aims will include evaluating the prospective relationship of these novel cardiovascular risk factors to the progression of atherosclerosis and the development of macrovascular disease in this same population. ..
  19. CONTROL OF FIBRIN TURNOVER IN PLEURAL DISEASE
    Steven Idell; Fiscal Year: 2004
    ..This work could identify better, clinically feasible therapeutic approaches to prevent pleural fibrosis. ..
  20. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  21. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  22. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  23. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  24. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  25. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  26. Reinstallation of functional p53 in glial tumors in vivo
    Ksenya Shchors; Fiscal Year: 2006
    ..Overall, the proposed research will significantly contribute to the understanding of gliomagenesis. ..
  27. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  28. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  29. The role of cardiolipin apoptosis
    DIANE HICKSON BICK; Fiscal Year: 2007
    ..The role of these modified phospholipids in cyt c release will be determined. We will answer the question "is the loss of cyt c preceded by deacylation of CL?" [unreadable] [unreadable]..
  30. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..