RET

Summary

Gene Symbol: RET
Description: ret proto-oncogene
Alias: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51, proto-oncogene tyrosine-protein kinase receptor Ret, CUX1/RET fusion, RET receptor tyrosine kinase, RET transforming sequence, cadherin family member 12, cadherin-related family member 16, hydroxyaryl-protein kinase, proto-oncogene c-Ret, rearranged during transfection, receptor tyrosine kinase, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
Species: human

Top Publications

  1. pmc Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
    Doron Lipson
    Foundation Medicine, Cambridge, Massachusetts, USA
    Nat Med 18:382-4. 2012
  2. ncbi PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
    M Grieco
    Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Universita di Napoli, Italy
    Cell 60:557-63. 1990
  3. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
  4. pmc Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism
    Ivan Plaza-Menacho
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, United Kingdom
    J Biol Chem 286:17292-302. 2011
  5. pmc Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma
    F Lesueur
    International Agency for Research on Cancer, Lyon, France
    J Med Genet 39:260-5. 2002
  6. doi RET revisited: expanding the oncogenic portfolio
    Lois M Mulligan
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Rev Cancer 14:173-86. 2014
  7. pmc Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells
    Rossana Foti
    Sector of Neurobiology, International School for Advanced Studies, Giovanni Armenise Harvard Foundation Laboratory, Area Science Park, SS 14, Km 163 5, Basovizza, Italy
    J Biol Chem 285:18565-74. 2010
  8. pmc Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the Chinese population
    Belinda K Cornes
    Paediatric Surgery Division, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e10918. 2010
  9. pmc ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    M Takahashi
    Mol Cell Biol 7:1378-85. 1987
  10. ncbi Germ-line mutations in nonsyndromic pheochromocytoma
    Hartmut P H Neumann
    Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
    N Engl J Med 346:1459-66. 2002

Research Grants

  1. Pasi A Janne; Fiscal Year: 2016
  2. Ret Signaling in Paraneoplastic Peripheral Neuropathy
    JOSEPHINE FOX; Fiscal Year: 2009
  3. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
  4. Khalid Matrougui; Fiscal Year: 2014
  5. GERTRUD M SCHUPBACH; Fiscal Year: 2016
  6. Gadiparthi N Rao; Fiscal Year: 2016
  7. Fu Shin X Yu; Fiscal Year: 2016
  8. Jia Luo; Fiscal Year: 2016
  9. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
  10. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010

Detail Information

Publications316 found, 100 shown here

  1. pmc Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
    Doron Lipson
    Foundation Medicine, Cambridge, Massachusetts, USA
    Nat Med 18:382-4. 2012
    ..alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma...
  2. ncbi PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
    M Grieco
    Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Universita di Napoli, Italy
    Cell 60:557-63. 1990
    ..We designated this transforming gene PTC (for papillary thyroid carcinoma). Here we describe the molecular cloning and sequencing of the gene...
  3. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
    In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive...
  4. pmc Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism
    Ivan Plaza-Menacho
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, United Kingdom
    J Biol Chem 286:17292-302. 2011
    Whether RET is able to directly phosphorylate and activate downstream targets independently of the binding of proteins that contain Src homology 2 or phosphotyrosine binding domains and whether mechanisms in trans by cytoplasmic kinases ..
  5. pmc Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma
    F Lesueur
    International Agency for Research on Cancer, Lyon, France
    J Med Genet 39:260-5. 2002
    ..Somatic rearrangements of the RET proto-oncogene are present in up to 66% of sporadic tumours, while they are rarely found in familial cases.
  6. doi RET revisited: expanding the oncogenic portfolio
    Lois M Mulligan
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Rev Cancer 14:173-86. 2014
    The RET receptor tyrosine kinase is crucial for normal development but also contributes to pathologies that reflect both the loss and the gain of RET function...
  7. pmc Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells
    Rossana Foti
    Sector of Neurobiology, International School for Advanced Studies, Giovanni Armenise Harvard Foundation Laboratory, Area Science Park, SS 14, Km 163 5, Basovizza, Italy
    J Biol Chem 285:18565-74. 2010
    ..Here we show that DJ-1 plays an essential role in the expression of rearranged during transfection (RET), a receptor for the glial cell line-derived neurotrophic factor, a neuroprotective molecule for ..
  8. pmc Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the Chinese population
    Belinda K Cornes
    Paediatric Surgery Division, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e10918. 2010
    ..The RET gene is the major gene implicated in this gastrointestinal disease...
  9. pmc ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    M Takahashi
    Mol Cell Biol 7:1378-85. 1987
    The ret transforming gene was activated by recombination between two unlinked segments of human DNA, most likely during transfection of NIH 3T3 cells. To further define this transforming gene, we isolated and sequenced ret cDNA clones...
  10. ncbi Germ-line mutations in nonsyndromic pheochromocytoma
    Hartmut P H Neumann
    Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
    N Engl J Med 346:1459-66. 2002
    The group of susceptibility genes for pheochromocytoma that included the proto-oncogene RET (associated with multiple endocrine neoplasia type 2 [MEN-2]) and the tumor-suppressor gene VHL (associated with von Hippel-Lindau disease) now ..
  11. ncbi RET mutations in exons 13 and 14 of FMTC patients
    A Bolino
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Oncogene 10:2415-9. 1995
    RET is a receptor tyrosine kinase gene which is responsible for three different inherited cancer syndromes namely multiple endocrine neoplasia type 2A (MEN 2A), type 2B (MEN 2B) and familial medullary thyroid carcinoma (FMTC) as well as ..
  12. ncbi GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
    S Jing
    Department of Immunology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Cell 85:1113-24. 1996
    ..GDNFR-alpha binds GDNF specifically and mediates activation of the Ret protein-tyrosine kinase (PTK)...
  13. ncbi Y791F RET mutation and early onset of medullary thyroid carcinoma in a Brazilian kindred: evaluation of phenotype-modifying effect of germline variants
    Rosana Tamanaha
    Clin Endocrinol (Oxf) 67:806-8. 2007
  14. doi New mutations in the RET protooncogene-L881V - associated with medullary thyroid carcinoma and -R770Q - in a patient with mixed medullar/follicular thyroid tumour
    K Frank-Raue
    Endocrine Practice, Molecular Laboratory, Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 118:550-3. 2010
    Clinical studies are needed to classify rare and novel RET mutations associated with hereditary medullary thyroid carcinoma (MTC) into one of the clinical risk groups...
  15. doi RET 3'UTR polymorphisms and its protective role in Hirschsprung disease in southeastern Chinese
    Zhi Wen Pan
    Institute of Cell Biology, Zhejiang University, Hangzhou 310058, China
    J Pediatr Surg 47:1699-705. 2012
    ..Several RET polymorphisms and haplotypes have been described as underrepresented in HSCR patients with respect to controls...
  16. doi Thyroid cancer and co-occurring RET mutations in Hirschsprung disease
    Valtter B Virtanen
    Section of Pediatric Surgery, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, Helsinki, Finland
    Endocr Relat Cancer 20:595-602. 2013
    The objective of this study was to assess the occurrence of thyroid cancer and co-occurring RET mutations in a population-based cohort of adult Hirschsprung disease (HD) patients...
  17. pmc Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans
    Ivan Plaza-Menacho
    Structural Biology Laboratory, London Research Institute, Cancer Research UK, WC2A 3LY London, UK Electronic address
    Mol Cell 53:738-51. 2014
    To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry...
  18. ncbi Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line
    T Tahira
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 5:97-102. 1990
    The ret proto-oncogene expresses four major mRNA species of different lengths in human malignant cell lines and rat tissues...
  19. ncbi An autocrine loop involving ret and glial cell-derived neurotrophic factor mediates retinoic acid-induced neuroblastoma cell differentiation
    Laura Cerchia
    Istituto per l Endocrinologia e l Oncologia Sperimentale del Consiglio Nazionale delle Ricerche G Salvatore, Naples, Italy
    Mol Cancer Res 4:481-8. 2006
    ..factor receptors, including Trk family receptors and the glial cell-derived neurotrophic factor receptor, Ret. In several cases, increased expression is dependent on signaling through TrkB...
  20. ncbi RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface
    P Runeberg-Roos
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    Oncogene 26:7909-15. 2007
    ..is an autosomal dominant cancer syndrome caused by an oncogenic form of the receptor tyrosine kinase REarranged during transfection (RET)...
  21. pmc CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction
    Cynthia C Tsui
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0680, USA
    J Neurosci 28:8789-800. 2008
    ..GFLs promote survival and growth via activation of the receptor tyrosine kinase (RTK) Ret...
  22. doi Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a novel syndromic association
    Alessio Pini Prato
    Department of Pediatric Surgery, Giannina Gaslini Institute, Genoa, Italy
    Medicine (Baltimore) 88:83-90. 2009
    ..we designed a prospective study aimed at determining the prevalence of CAKUT in HSCR patients and at identifying RET, glial cell line-derived neurotrophic factor (GDNF), and GDNF family receptor alpha1 (GFRalpha1) mutations or ..
  23. doi Intronic RET gene variants in Down syndrome-associated Hirschsprung disease in an African population
    Samuel W Moore
    Division of Paediatric Surgery, Faculty of Medicine, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    J Pediatr Surg 47:299-302. 2012
    Clinical association between Hirschsprung disease (HD) and Down syndrome (DS) is well established. RET promoter and intron 1 variations have been shown to interfere with RET function, increasing the risk of HD pathogenesis...
  24. doi Association of genetic polymorphisms in the RET-protooncogene and NRG1 with Hirschsprung disease in Thai patients
    Theerawut Phusantisampan
    Center for Genomics and Bioinformatics Research, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Hum Genet 57:286-93. 2012
    ..disease (HSCR) is a congenital developmental defect of the enteric nervous system known to be associated with the RET-protooncogene and other candidates...
  25. pmc Alternative splicing results in RET isoforms with distinct trafficking properties
    Douglas S Richardson
    Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, ON, Canada
    Mol Biol Cell 23:3838-50. 2012
    RET encodes a receptor tyrosine kinase that is essential for spermatogenesis, development of the sensory, sympathetic, parasympathetic, and enteric nervous systems and the kidneys, as well as for maintenance of adult midbrain dopaminergic ..
  26. doi KIF5B-RET fusions in Chinese patients with non-small cell lung cancer
    Weijing Cai
    Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Tongji University Medical School Cancer Institute, Shanghai, People s Republic of China
    Cancer 119:1486-94. 2013
    It has been established that "ret proto-oncogene" (RET) fusions are oncogenic drivers in non-small cell lung cancer (NSCLC)...
  27. pmc A rare haplotype of the RET proto-oncogene is a risk-modifying allele in hirschsprung disease
    Paola Griseri
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Am J Hum Genet 71:969-74. 2002
    ..HSCR demonstrates a complex pattern of inheritance, with the RET proto-oncogene acting as a major gene and with several additional susceptibility loci related to the Ret-signaling ..
  28. doi Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells
    Ai Kurotsuchi
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:1147-55. 2010
    ..the plasma membrane via its pleckstrin homology (PH) domain, and was phosphorylated following RET activation via a MEN2A mutation or GDNF stimulation...
  29. ncbi A RET double mutation in the germline of a kindred with FMTC
    D K Bartsch
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 108:128-32. 2000
    Activating germline mutations of the RET proto-oncogene are found in more than 90% of families with multiple endocrine neoplasia type 2a (MEN 2a) and familial medullary thyroid carcinoma (FMTC)...
  30. ncbi Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions
    M Cik
    Department of Biochemical Pharmacology and the Department of Biotechnology and High Throughput Screening, Janssen Research Foundation, B 2340 Beerse, Belgium
    J Biol Chem 275:27505-12. 2000
    ..These results suggest an interaction of GFRalpha1 and cRET in the absence of GDNF and demonstrate that the high affinity binding can be measured only when cRET is present...
  31. ncbi Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age
    Marina Quartu
    Department of Cytomorphology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy
    Brain Res 1173:36-52. 2007
    ..of receptor components of the glial cell line-derived neurotrophic factor (GDNF) family ligands, the Ret receptor tyrosine kinase and the GDNF family receptor (GFR) alpha-1 to -3, were examined by immunohistochemistry in the normal ..
  32. doi Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones
    Raffaella Cincinelli
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy
    J Med Chem 51:7777-87. 2008
    ..and 3,10-dihydro-2H-azepino[3,4-b]indol-1-ones have been designed, synthesized, and evaluated as RET protein kinase inhibitors on the basis of their structural similarity with the prototype indolin-2-one RPI-1...
  33. doi Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo
    I Fischer
    Ludwig Maximilians University of Munich, Department of Obstetrics and Gynecology, Munich, Germany
    Placenta 30:1078-82. 2009
    ....
  34. ncbi Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR)
    Guido Fitze
    Department of Pediatric Surgery, University of Technology Dresden, Germany
    Hum Mol Genet 12:3207-14. 2003
    The activation of the RET signaling pathway during embryogenesis is a crucial prerequisite for a directional migration of enteric nervous system progenitor cells...
  35. ncbi A novel Val648Ile substitution in RET protooncogene observed in a Cys634Arg multiple endocrine neoplasia type 2A kindred presenting with an adrenocorticotropin-producing pheochromocytoma
    Adriana B Nunes
    Endocrine Genetics Unit, Department of Endocrinology, University of Sao Paulo School of Medicine, 01246 903 Sao Paulo, Brazil
    J Clin Endocrinol Metab 87:5658-61. 2002
    ..a heterogeneous group of neoplasic disorders that most commonly have a single missense substitution of the RET protooncogene (RET) involving exons 10 and 11...
  36. doi Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness
    Lucieli Ceolin
    Thyroid Section, Endocrine Division, Servico de Endocrinologia, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035 003 Porto Alegre, RS, Brazil
    Eur J Endocrinol 166:847-54. 2012
    b>RET single nucleotide polymorphisms (SNPs) have been implicated in the pathogenesis and progression of medullary thyroid carcinoma (MTC)...
  37. doi Difference in development of medullary thyroid carcinoma among carriers of RET mutations in codons 790 and 791
    Karin Frank-Raue
    Endocrine Practice, Molecular Laboratory, Heidelberg, Germany
    Clin Endocrinol (Oxf) 69:259-63. 2008
    Hereditary medullary thyroid carcinoma (MTC) is caused by germ-line mutations in the RET proto-oncogene. Our study addresses the difference in development of MTC between rare mutations in RET codons 790, 791 and 804.
  38. pmc DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells
    M Gandhi
    Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 29:2272-80. 2010
    ..Here, we studied the involvement of fragile sites in the formation of RET/PTC rearrangements, which are frequently found in papillary thyroid carcinoma (PTC)...
  39. ncbi Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    M Takahashi
    Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Japan
    Oncogene 3:571-8. 1988
    The nucleotide sequence of the ret proto-oncogene has been determined from cDNA clones isolated from a cDNA library of a THP-1 human monocytic leukemia cell line...
  40. pmc Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype
    M Santoro
    Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita di Napoli, Italy
    J Clin Invest 89:1517-22. 1992
    ..This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene...
  41. ncbi Germline mutation of RET codon 883 in two cases of de novo MEN 2B
    D P Smith
    University of Cambridge, Department of Pathology, UK
    Oncogene 15:1213-7. 1997
    Germline mutations in the RET proto-oncogene are seen in the majority of patients with the dominantly inherited cancer syndromes multiple endocrine neoplasia type 2 (MEN 2)...
  42. pmc A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma
    Salud Borrego
    Unidad de Genética Medica y Diagnóstico Prenatal, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
    Am J Hum Genet 72:88-100. 2003
    ..Yet, germline mutations in the RET proto-oncogene are associated with both MEN 2 and HSCR...
  43. ncbi Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome
    Jeanne Amiel
    Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM U 393, et Département de Génétique, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Nat Genet 33:459-61. 2003
    ..Our data support an essential role of PHOX2B in the normal patterning of the autonomous ventilation system and, more generally, of the ANS in humans...
  44. doi RET-mediated gene expression pattern is affected by isoform but not oncogenic mutation
    Jessica G Hickey
    Division of Cancer Biology and Genetics, Cancer Research Institute Queen s University, Kingston, ON, Canada, K7L 3N6
    Genes Chromosomes Cancer 48:429-40. 2009
    The inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN 2) is caused by mutations of the RET receptor tyrosine kinase and is characterized by medullary thyroid carcinoma...
  45. ncbi RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
    M J Lorenzo
    CRC Human Cancer Genetics Research Group, University of Cambridge, Department of Pathology, Cambridge, UK
    Oncogene 14:763-71. 1997
    Activating germline mutations of the RET receptor tyrosine kinase are found in the majority of cases of inherited cancer syndrome MEN 2, and inactivating mutations in some cases of dominantly inherited Hirschsprung disease...
  46. doi A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma
    Taranjit S Gujral
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer Res 68:1338-46. 2008
    The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation...
  47. doi Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins
    Douglas S Richardson
    Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer Res 69:4861-9. 2009
    Mutations to the RET proto-oncogene occur in as many as one in three cases of thyroid cancer and have been detected in both the medullary (MTC) and the papillary (PTC) forms of the disease...
  48. ncbi Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
    H Donis-Keller
    Division of Human Molecular Genetics, Washington University School of Medicine, St Louis, MO 63110
    Hum Mol Genet 2:851-6. 1993
    ..The variants were observed only in the DNA of individuals who were either affected or who had inherited the MEN2A or FMTC allele as determined by haplotyping experiments. The seven variants identified were sequenced directly...
  49. ncbi Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation
    R A Decker
    The Charlie Hays Division of Cancer Research, The Decker Foundation, 7536 Forsyth Boulevard, St Louis, MO 63105, USA
    Hum Mol Genet 7:129-34. 1998
    ..MEN 2B) and familial medullary thyroid carcinoma (FMTC), as well as some cases of familial Hirschsprung disease (HSCR1)...
  50. ncbi A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A
    I Berndt
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    J Clin Endocrinol Metab 83:770-4. 1998
    ..type 2A (MEN-2A) or familial medullary thyroid carcinoma (FMTC) have been investigated for mutations in the ret protooncogene in Germany...
  51. ncbi Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase
    Toshifumi Fukuda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    J Biol Chem 277:19114-21. 2002
    ..Here we show that increased serine phosphorylation on RET receptor tyrosine kinase following cAMP elevation promotes lamellipodia formation of neuronal cells induced by glial cell line-..
  52. pmc A novel susceptibility locus for Hirschsprung's disease maps to 4q31.3-q32.3
    A S Brooks
    J Med Genet 43:e35. 2006
    ..Analysis of the RET gene, the major gene involved in HSCR susceptibility, revealed neither linkage nor mutations...
  53. doi Current management of medullary thyroid cancer
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Wisconsin 53792 7375, USA
    Oncologist 13:539-47. 2008
    ..The majority of medullary thyroid cancers are sporadic, but 20% of cases are a result of a germline mutation in the ret proto-oncogene...
  54. ncbi Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence
    M Takahashi
    Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Oncogene 4:805-6. 1989
    Our recent studies suggested that the ret proto-oncogene protein is a cell surface receptor with a tyrosine kinase domain. However, the sequence of its cDNA lacked an amino-terminal signal sequence characteristic of membrane proteins...
  55. ncbi Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:2163-7. 1994
    Mutations of the RET proto-oncogene are the underlying cause of some cases of Hirschsprung disease (HSCR) and the inherited cancer syndromes multiple endocrine neoplasia types 2A (MEN 2A) and 2B (MEN 2B) and familial medullary thyroid ..
  56. ncbi Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nature 363:458-60. 1993
    ..2 (refs 2,3). The DNA segment encompasses the RET proto-oncogene, a receptor tyrosine kinase gene expressed in MTC and phaeochromocytoma and at lower levels in normal human thyroid...
  57. ncbi A codon 891 exon 15 RET proto-oncogene mutation in familial medullary thyroid carcinoma: a detection strategy
    G T Dang
    The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
    Mol Cell Probes 13:77-9. 1999
    A ser891ala RET proto-oncogene mutation has been previously discovered in a single kindred with familial medullary thyroid carcinoma (FMTC)...
  58. pmc A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus
    S Bolk
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA
    Proc Natl Acad Sci U S A 97:268-73. 2000
    ..pattern of inheritance with approximately 50% of familial cases being heterozygous for mutations in the receptor tyrosine kinase RET...
  59. ncbi Genotype-phenotype correlations in hereditary medullary thyroid carcinoma: oncological features and biochemical properties
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 86:1104-9. 2001
    In hereditary medullary thyroid carcinoma (MTC), few genotype-phenotype correlations have been established. RET genotypes (exons 10, 11, 13, and 14) of 63 patients with hereditary MTC (from November 1994 to October 1999) were correlated ..
  60. ncbi MEN2A-RET-induced cellular transformation by activation of STAT3
    J J Schuringa
    Department of Developmental Genetics, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
    Oncogene 20:5350-8. 2001
    The MEN2A oncogene encodes for a constitutive active member of the RET receptor tyrosine kinase family...
  61. ncbi Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation
    Jung Hwan Hwang
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University College of Medicine, 640 Daesadong Chungku, Daejeon 301 721, Korea
    Mol Endocrinol 17:1155-66. 2003
    Thyroid papillary carcinomas are characterized by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) rearrangements that result in fusion of the tyrosine kinase domain of the RET receptor to the N-terminal sequences ..
  62. ncbi Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase
    Rizaldy P Scott
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    J Biol Chem 280:13442-9. 2005
    ..Although in vitro studies have demonstrated a higher transforming activity of the long RET isoform (RET51), only the short isoform (RET9) can rescue the effects of a RET null mutation in the enteric nervous system and ..
  63. pmc Identifying candidate Hirschsprung disease-associated RET variants
    Grzegorz M Burzynski
    Department of Medical Genetics, University of Groningen, Groningen, The Netherlands
    Am J Hum Genet 76:850-8. 2005
    Patients with sporadic Hirschsprung disease (HSCR) show increased allele sharing at markers in the 5' region of the RET locus, indicating the presence of a common ancestral RET mutation...
  64. ncbi Genetic testing in pheochromocytoma or functional paraganglioma
    Laurence Amar
    Universite Paris Descartes, Faculte de Medecine, France
    J Clin Oncol 23:8812-8. 2005
    ..To assess the yield and the clinical value of systematic screening of susceptibility genes for patients with pheochromocytoma (pheo) or functional paraganglioma (pgl)...
  65. ncbi RET proto-oncogene mutations are restricted to codons 634 and 918 in mainland Chinese families with MEN2A and MEN2B
    Yulin Zhou
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Jiao Tong University, Shanghai
    Clin Endocrinol (Oxf) 67:570-6. 2007
    ..gain-of-function mutations in the RET proto-oncogene, which includes multiple endocrine neoplasia type 2A (MEN2A), type 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC)...
  66. doi Contribution of RET, NTRK3 and EDN3 to the expression of Hirschsprung disease in a multiplex family
    A Sánchez-Mejías
    Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Hospital Universitario Virgen del Rocio, Seville, Spain
    J Med Genet 46:862-4. 2009
    ..Although HSCR commonly appears as a sporadic trait, approximately 20% of HSCR cases are familial, with complex patterns of inheritance...
  67. ncbi Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease
    T Attie
    Service de Genetique Medicale, INSERM U 393, Institut Necker, Hopital des Enfants Malades, Paris, France
    Hum Mol Genet 4:1381-6. 1995
    ..2 and the disease has been ascribed to mutations in a tyrosine kinase receptor gene mapping to this region, the RET proto-oncogene...
  68. ncbi Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
    X Liu
    Department of Biological Chemistry, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    J Biol Chem 271:5309-12. 1996
    The c-ret proto-oncogene encodes a receptor tyrosine kinase which plays an important role in neural crest as well as kidney development...
  69. pmc The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
    M G Borrello
    Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy
    Mol Cell Biol 16:2151-63. 1996
    b>RET/PTC oncogenes, generated by chromosomal rearrangements in papillary thyroid carcinomas, are constitutively activated versions of proto-RET, a gene coding for a receptor-type tyrosine kinase (TK) whose ligand is still unknown...
  70. pmc Association of RET protooncogene codon 45 polymorphism with Hirschsprung disease
    G Fitze
    Am J Hum Genet 65:1469-73. 1999
  71. ncbi A common haplotype at the 5' end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression
    Paola Griseri
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Hum Mutat 25:189-95. 2005
    ..HSCR) is a complex genetic defect of intestinal innervation mainly ascribed to loss of function mutations of the RET gene...
  72. doi RET polymorphisms and the risk of Hirschsprung's disease in a Chinese population
    Cuiping Liu
    Institute of Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China
    J Hum Genet 53:825-33. 2008
    ..b>RET coding mutations have been found in approximately 50% of familial cases, but they only explain a minority of ..
  73. ncbi Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart
    T Shoba
    Department of Anatomy, Faculty of Medicine, MD 10, 4 Medical Drive, National University of Singapore, 117 597, Singapore, Singapore
    Neurosci Lett 318:129-32. 2002
    We analyzed the expression of neuronal regulatory genes Mash-1 and c-ret by immunohistochemistry and reverse transcriptase-polymerase chain reaction in the developing heart of rat embryos following exogenous retinoic acid (RA) treatment ..
  74. ncbi Within-gene interaction between c.135 G/A genotypes and RET proto-oncogene germline mutations in HSCR families
    G Fitze
    Department of Paediatric Surgery, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Eur J Pediatr Surg 13:152-7. 2003
    ..Several genes, including the major HSCR-susceptibility RET proto-oncogene, play an aetiological role in the development of HSCR...
  75. ncbi Regulation of signal transducer and activator of transcription 1 (STAT1) and STAT1-dependent genes by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncogenic tyrosine kinases
    Eun Suk Hwang
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Seoul National University College of Medicine, Seoul, Korea
    Mol Endocrinol 18:2672-84. 2004
    Chimeric RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncoproteins are constitutively active tyrosine kinases found in thyroid papillary carcinoma and nonneoplastic Hashimoto's thyroiditis...
  76. ncbi RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors
    Valentina De Falco
    Instituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Via S Pansini 5, 80131 Naples, Italy
    Oncogene 24:6303-13. 2005
    RAI, also named ShcC/N-Shc, one of the members of the Shc proteins family, is a substrate of the RET receptor tyrosine kinase. Here, we show that RAI forms a protein complex with both RET/MEN 2 A and RET/PTC oncoproteins...
  77. ncbi Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
    Keiko Shimono
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 280:39436-47. 2005
    ..protein), we found that Mi-2beta, a component of a nucleosome remodeling and deacetylase (NuRD) complex, RET finger protein (RFP), and upstream binding factor (UBF) were associated with MCRS1...
  78. ncbi Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET
    S M Myers
    Department of Pathology, Queen s University, Kingston, ON, Canada
    Oncogene 11:2039-45. 1995
    The RET proto-oncogene, which encodes a receptor tyrosine kinase, displays multiple alternative splicing variants...
  79. ncbi Exon structure and flanking intronic sequences of the human RET proto-oncogene
    I Ceccherini
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Biochem Biophys Res Commun 196:1288-95. 1993
    ..for the screening of recently reported missense mutations of RET which cause Multiple Endocrine Neoplasia 2A (MEN2A) and for the search of additional point mutations of the same gene which might cause two other neural crest ..
  80. ncbi Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nat Genet 6:70-4. 1994
    ..84% of the MEN2A mutations affected codon 634...
  81. ncbi Mutations of the RET proto-oncogene in Hirschsprung's disease
    P Edery
    Service de Genetique Medicale, Clinique Chirurgicale Infantile, Hopital Necker Enfants Malades, Paris, France
    Nature 367:378-80. 1994
    ..2 (refs 6, 7). No recombination was observed between the disease locus and the locus for the RET proto-oncogene, a protein tyrosine kinase gene expressed in the cells derived from the neural crest...
  82. ncbi A gene for Hirschsprung disease maps to the proximal long arm of chromosome 10
    S Lyonnet
    Départment de pédiatrie, l Enfant INSERM U 12 Hôpital des Enfants Malades, Paris, France
    Nat Genet 4:346-50. 1993
    ..2, a region to which other neural crest defects have been mapped...
  83. ncbi The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    C Eng
    Division of Cancer Epidemiology and Control, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115 6084, USA
    JAMA 276:1575-9. 1996
    ..The purpose of this study was to establish the relationship between specific mutations and the presence of certain disease features in MEN 2 which could help in clinical decision making...
  84. ncbi Frequency of RET mutations in long- and short-segment Hirschsprung disease
    M Seri
    Laboratorio Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    Hum Mutat 9:243-9. 1997
    ..Mutations in the RET proto-oncogene, repeatedly identified in the heterozygous state in both long- and short-segment Hirschsprung ..
  85. ncbi Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation
    O Gimm
    Translational Research Laboratory, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 82:3902-4. 1997
    ..More than 95% of all MEN 2B cases are caused by germline mutation at codon 918 (M918T) in exon 16 of the RET proto-oncogene...
  86. ncbi Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma
    T Iwashita
    Department of Pathology, Nagoya University School of Medicine, Japan
    Oncogene 18:3919-22. 1999
    Several mutations were identified in the kinase domain of the RET proto-oncogene in patients with multiple endocrine neoplasia (MEN) 2B, familial medullary thyroid carcinoma (FMTC) or sporadic medullary thyroid carcinoma...
  87. pmc RET genotypes comprising specific haplotypes of polymorphic variants predispose to isolated Hirschsprung disease
    S Borrego
    Unidad de Genética Medica y Diagnóstico Prenatal, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    J Med Genet 37:572-8. 2000
    ..Germline mutations of the RET proto-oncogene are believed to account for up to 50% of familial cases and up to 30% of isolated cases in most ..
  88. ncbi Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins
    D Salvatore
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto Nazionale dei Tumori di Napoli, Naples, Italy
    J Clin Endocrinol Metab 85:3898-907. 2000
    Point mutations of the RET receptor tyrosine kinase are responsible for the inheritance of multiple endocrine neoplasia (MEN) type 2 syndromes and are also present in a fraction of sporadic medullary thyroid carcinomas...
  89. ncbi RET/PTC rearrangement in thyroid tumors
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Endocr Pathol 13:3-16. 2002
    Rearrangement of the RET gene, also known as RET/PTC rearrangement, is the most common genetic alteration identified to date in thyroid papillary carcinomas...
  90. ncbi Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival
    Mario Encinas
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:18262-9. 2004
    ..GFLs signal through a common receptor tyrosine kinase (Ret) and one of the four ligand-binding co-receptors (GFRalpha1 to 4)...
  91. ncbi The RET IVS1-126G>T variant is strongly associated with the development of sporadic medullary thyroid cancer
    R M Fernandez
    Thyroid 14:329-31. 2004
  92. ncbi Investigation of loss of heterozygosity and SNP frequencies in the RET gene in papillary thyroid carcinoma
    L A Stephens
    Human Cancer Studies Group, Swansea Clinical School, University of Wales, Swansea SA2 8PP, UK
    Thyroid 15:100-4. 2005
    In both medullary carcinoma and papillary carcinoma of the thyroid, altered expression of the RET gene is implicated in tumorigenesis...
  93. pmc Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase
    Laura Cerchia
    Istituto per I Endocrinologia e Oncologia Molecolare G Salvatore, CNR, Naples, Italy
    PLoS Biol 3:e123. 2005
    ..Nuclease-resistant aptamers that recognize the human receptor tyrosine kinase RET were obtained using RET-expressing cells as targets in a modified SELEX procedure...
  94. ncbi Low RET mutation frequency and polymorphism analysis of the RET and EDNRB genes in patients with Hirschsprung disease in Taiwan
    Trang Tiau Wu
    Department of Pediatric Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China
    J Hum Genet 50:168-74. 2005
    ..Mutations in genes of the RET receptor tyrosine kinase and endothelin receptor B (EDNRB) signaling pathways have been shown to be associated in HSCR patients...
  95. ncbi Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg
    S Dvorakova
    Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic
    J Endocrinol Invest 28:905-9. 2005
    ..thyroid carcinoma (FMTC) is an autosomal dominant inherited disease, characterized by germ-line mutations in the RET proto-oncogene, mainly in exons 10 and 11, but also in exons 13, 14 and 15...
  96. ncbi Molecular mechanisms of RET-induced Hirschsprung pathogenesis
    Francesca Lantieri
    Lab Genetica Molecolare, Ist G Gaslini, Genova, Italy
    Ann Med 38:11-9. 2006
    The RET proto-oncogene is the major gene involved in the pathogenesis of Hirschsprung (HSCR), a complex genetic disease characterized by lack of ganglia along variable lengths of the gut...
  97. ncbi Analysis of RET polymorphisms and haplotypes in the context of sporadic medullary thyroid carcinoma
    Raquel M Fernandez
    Unidad Clínica de Genética y Reproducción, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
    Thyroid 16:411-7. 2006
    ..While germline gain-of-function mutations in the RET proto-oncogene cause hereditary MTC, the molecular mechanisms leading to the sporadic forms remain obscure...
  98. ncbi Single nucleotide polymorphisms in the RET gene and their correlations with Hirschsprung disease phenotype
    Robert Smigiel
    Genetics Department, Medical University, Wrocław, Poland
    J Appl Genet 47:261-7. 2006
    ..Recent advances show that the RET gene is a major locus involved in the pathogenesis of HSCR...
  99. ncbi Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation
    Ivan Plaza-Menacho
    Department of Genetics, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    J Biol Chem 282:6415-24. 2007
    The precise role of STAT3 Ser(727) phosphorylation in RET-mediated cell transformation and oncogenesis is not well understood...
  100. pmc Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population
    Xiaoping Miao
    Gut 56:736. 2007
  101. ncbi Genetic analysis of RET, EDNRB, and EDN3 genes and three SNPs in MCS + 9.7 in Chinese Patients with isolated Hirschsprung disease
    Xian ning Zhang
    National Education Base for Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P R China
    Biochem Genet 45:523-7. 2007

Research Grants76

  1. Pasi A Janne; Fiscal Year: 2016
    ..RET is transmembrane receptor tyrosine kinase that is normally expressed in cells derived from neural crest and the urogenital tract...
  2. Ret Signaling in Paraneoplastic Peripheral Neuropathy
    JOSEPHINE FOX; Fiscal Year: 2009
    ..and papillary carcinoma patients, is caused by autoantibodies specific for the extracellular domain of the c-RET tyrosine kinase receptor...
  3. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..tracheal system is controlled by patterned interactions between a fibroblast growth factor (FGF) receptor tyrosine kinase (TK) ortholog, Breathless (Btl), and its FGF ligand, Branchless (Bnl)...
  4. Khalid Matrougui; Fiscal Year: 2014
    ..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes.
  5. GERTRUD M SCHUPBACH; Fiscal Year: 2016
    ..Factor receptor (Egfr) during oogenesis, and the cellular pathways that mediate the response to this receptor tyrosine kinase in the ovarian follicle cells...
  6. Gadiparthi N Rao; Fiscal Year: 2016
    ..receptor agonist and a clotting factor that is produced at the site of vascular injury could transactivate receptor tyrosine kinase signaling in the stimulation of both VSMC migration and proliferation and ignite the disease process.
  7. Fu Shin X Yu; Fiscal Year: 2016
    ..studies in the current grant period demonstrated that epidermal growth factor receptor (EGFR) is the key receptor tyrosine kinase activated upon wounding, and the wound-induced activation of EGFR and its downstream signaling pathways, ..
  8. Jia Luo; Fiscal Year: 2016
    ..ErbB2, a member of the epidermal growth factor receptor tyrosine kinase family, is frequently over-expressed in human breast cancers...
  9. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..c-Met, also known as the hepatocyte growth factor receptor, is a receptor tyrosine kinase that regulates cell proliferation, differentiation, migration and apoptosis...
  10. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..theme is that GPCR agonists also induce tyrosine phosphorylation of multiple proteins, including the non-receptor tyrosine kinase p125 focal adhesion kinase (FAK) and the adaptor proteins p130 Crk-associated substrate (CAS) and ..
  11. Barry M Gumbiner; Fiscal Year: 2014
    ..of mammary glands and mammary tumors in vivo in mice, and their roles in tumorigenesis driven by Receptor Tyrosine Kinase (RTK) and SFK signaling pathways...
  12. Regulation of EGFR Signaling by the Endocytic Pathway
    Brian P Ceresa; Fiscal Year: 2013
    ..To understand this process, we are using the prototypical receptor tyrosine kinase, the epidermal growth factor receptor (EGFR), as a model...
  13. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..We expect this research to lead to improved control of PTC with regard to early disease detection and better disease management and, thus, to enhance public health services.
  14. Jessica E Treisman; Fiscal Year: 2016
    ..encoding Mitogen-activated protein kinase (MAPK), an essential downstream component of the EGFR and other receptor tyrosine kinase signaling pathways...
  15. Receptor Tyrosine Kinase Signaling Networks
    Joannes B Hoek; Fiscal Year: 2010
    ....
  16. TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORS
    Scott H Kaufmann; Fiscal Year: 2010
    ..examining drug combinations, we showed that topo I poisons synergize with the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774 (based on the ability of OSI-774 to inhibit efflux of SN-38 by the ABCG2 transporter) ..
  17. Advanced Anatomic and Functional Response Assessment in Lung Cancer
    Lawrence H Schwartz; Fiscal Year: 2011
    ..Radiographic changes in tumors treated with epidermal growth factor receptor tyrosine kinase inhibitors such as gefitinib or erlotinib or inhibitors of angiogenesis such as bevacizumab do not ..
  18. Philip A Cole; Fiscal Year: 2016
    ..abstract_text> ..
  19. Ron Bose; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Her2 is a receptor tyrosine kinase and cellular proto-oncogene that plays a major role in breast and other human cancers. Her2 is a member of the ErbB - epidermal growth factor receptor (EGFR) family...
  20. Matthew L Meyerson; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The epidermal growth factor receptor tyrosine kinase (EGFR) is one of the most commonly activated oncoproteins in lung adenocarcinoma, glioblastoma and other cancers...
  21. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Both the GDNF receptor, Ret, and the EDN3 receptor Endothelin receptor B (EDNRB) are expressed by the neural crest stem cells (NCSCs) that give ..
  22. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..NMD degrades mature mRNAs with a premature termination codon (PTC)...
  23. ANDREW GREGORY SIKORA; Fiscal Year: 2015
    ..Our preliminary data demonstrate that mice bearing syngeneic B16 or MT-RET melanomas accumulate splenic and tumor-infiltrating GR-1+CD11b+ MDSC, and experience a decline in splenic CD4+ and ..
  24. Subhash C Pandey; Fiscal Year: 2016
    ....
  25. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..GFLs activate receptor tyrosine kinase Ret in nociceptors and a subset of low threshold mechanoreceptors...
  26. John M Sullivan; Fiscal Year: 2016
    ..Accumulation of A2E/Ret-Di precedes spatial geographic loss of RPE cells and overlying PRs in dAMD/JMD...
  27. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..of NOX5 by hydrogen peroxide (H2O2) acting through a signaling pathway involving calcium and the non-receptor tyrosine kinase c-Abl...
  28. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..We identified a small molecule receptor tyrosine kinase inhibitor with activity against both PDGFR and KDR...
  29. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..In aim IV We will determine 1) the effect of Ac-SDKP on the non-receptor tyrosine kinase Src and HB-EGF on Ang II and ET-1-stimulated transactivation of the EGFR;2) whether Ac-SDKP inhibits the ..
  30. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..involves the ephrin-A3 ligand expressed on the surface of astrocytes in the hippocampus and the EphA4 receptor tyrosine kinase expressed on dendritic spines...
  31. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    The EphA4 receptor tyrosine kinase is highly expressed in the developing and adult nervous system, and is upregulated following nervous system injury. A number of important functions have been ascribed to this receptor in neural cells...
  32. Jordan A Kreidberg; Fiscal Year: 2014
    ..We have also demonstrated that the receptor tyrosine kinase c-Met requires interaction with 31 integrin for maximal activation in response to its ligand, HGF...
  33. Michael R Freeman; Fiscal Year: 2014
    ..The role of androgen, the androgen receptor, and ERBB receptor tyrosine kinase signaling in the amoeboid phenotype will be determined in the context of DRF3 silencing...
  34. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..of knee joints in both mutant mice;(3) the expression of a collagen receptor, the discoidin domain receptor tyrosine kinase 2 (Ddr2), is also increased in the articular cartilage of knee joints in both mutant mice;(4) the ..
  35. The role of the orphan receptor tyrosine kinase Ros1 in vascular disease
    ZIAD ANWAR ALI; Fiscal Year: 2011
    ..Thus, understanding how this receptor is activated and identifying the pathways that regulate its function may lead to new therapies for blood vessel disorders - currently the leading killer in the Western World. ..
  36. Pat Levitt; Fiscal Year: 2016
    ..First, to determine the mechanisms through which the receptor tyrosine kinase Met signaling system influences forebrain development...
  37. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ..cell lines representing primary and metastatic tumors of different histologic types and mutational subtypes (BRAF, RET/PTC, RAS, PIK3CA, AKT1, CTNNB1)...
  38. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..elegans a7 homologue, are dependent on CAM-1, a Ror class receptor tyrosine kinase (RTK)...
  39. Alex Kentsis; Fiscal Year: 2015
    ..I discovered that shRNA mediated depletion of hepatocyte growth factor (HGF), ligand of the receptor tyrosine kinase MET, specifically inhibits growth of AML but not other hematologic cancer cells...
  40. MICAH TAUBE WEBSTER; Fiscal Year: 2015
    ..c-Met encodes a receptor tyrosine kinase. Activation by its ligand, Hepatocyte Growth Factor (HGF), triggers multiple signaling cascades that ..
  41. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ..lymphoma (Cbl) is an adaptor protein with an intrinsic E3 ubiquitin ligase activity that targets receptor tyrosine kinase signaling, resulting in their ubiquitylation and proteasomal degradation...
  42. John David Sweatt; Fiscal Year: 2014
    ..The results from the proposed studies may help us to understand treatment-related pain in more detail, and may provide new molecular targets for analgesic therapy. ..
  43. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..However, diagnosis of AMR is one of the most challenging in renal pathology. Peritubular capillary (PTC) C4d staining is one of the markers of AMR...
  44. Control of developmental timing and body size in Drosophila
    MICHAEL BRENDAN O'CONNOR; Fiscal Year: 2013
    ..2 we will characterize additional upstream and downstream inputs that regulate PTTH signaling through the receptor tyrosine kinase Torso...
  45. RET RECEPTOR POLYMORPHISMS & HIRSCHSPRUNG DISEASE
    Charis Eng; Fiscal Year: 2004
    DESCRIPTION (Adapted from investigator's abstract): The RET proto-oncogene, encoding a receptor tyrosine kinase, is the susceptibility gene for Hirschsprung disease (HSCR), a congenital absence of enteric ganglia, and for multiple ..
  46. Latha Paka; Fiscal Year: 2014
    ..We identified a small molecule receptor tyrosine kinase inhibitor/s with activity against both PDGFR and KDR and optimized for solubility in Phase I program...
  47. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..by growth factors and extracellular matrix (ECM)-integrin interactions and that activation of the non-receptor tyrosine kinase, Focal Adhesion Kinase (FAK) plays a critical role in these signaling pathways...
  48. Apoptotic T Cell Clearance From Murine Lungs
    Jeffrey L Curtis; Fiscal Year: 2010
    ..This project has studied a receptor tyrosine kinase called MerTK, which is essential for MO uptake of AC...
  49. ROR1 as a Therapeutic Target in Acute Lymphoblastic Leukemia
    JEFFREY WALLACE TYNER; Fiscal Year: 2011
    ..Using this screen, we have identified a receptor tyrosine kinase, ROR1, that is uniquely and consistently overexpressed in all patients with t(1;19)-positive acute ..
  50. UTPAL P DAVE; Fiscal Year: 2016
    ..JAK3 is a non-receptor tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, ..
  51. Na,K-ATPase as an Integrator of the Calcium-signaling Machinery
    Zijian Xie; Fiscal Year: 2010
    ..the Na/K-ATPase is an important receptor that resides in caveolae and interacts directly with Src, a non-receptor tyrosine kinase. We know now that the effects of low doses of ouabain on many cellular functions are not due to the ..
  52. Gadiparthi N Rao; Fiscal Year: 2016
    ..Activation of calcineurin-NFAT signaling is required for both receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonist-induced vascular smooth muscle cell (VSMC) growth and ..
  53. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..AZD2171 is an oral, highly potent pan-VEGF receptor tyrosine kinase inhibitor that has been shown to generate significant inhibition of tumor growth in all human tumor ..
  54. ASISH KUMAR GHOSH; Fiscal Year: 2016
    ..B-cell survival, and sustained increases in cyclin D1 and c-myc, at least in part, by delivering Axl receptor tyrosine kinase (RTK)...
  55. Jie Wu; Fiscal Year: 2014
    ..Recurrent gene fusion between kinesin family member 5B (KIF5B) and the RET tyrosine kinase (KIF5B-RET) is the most recent genetic alternation identified in human lung adenocarcinoma...
  56. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..Second, is there crosstalk or transactivation between TrkA and another receptor tyrosine kinase, anaplastic lymphoma kinase (ALK)? ALK is frequently mutated in neuroblastoma, highly tyrosine ..
  57. Bruce D Gelb; Fiscal Year: 2016
    ..that additional genes causing NS will reside outside of the central RAS/MAPK pathway, perhaps altering receptor tyrosine kinase metabolism. To test this hypothesis, we will use a genetically unbiased approach toward gene discovery...
  58. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
    ..BRAFV600E, the most frequent genetic alteration in both papillary (PTC) and anaplastic thyroid cancers (ATC), is implicated in progression from PTC to ATC...
  59. Mark A Lemmon; Fiscal Year: 2016
    ..Both are receptor tyrosine kinase (RTK) families - a receptor class not typically associated with Wnt signaling, but a class that has been ..
  60. Manabu Kurokawa; Fiscal Year: 2014
    ..Overexpression of the receptor tyrosine kinase ErbB2 is known to be associated with poor prognosis in breast cancer patients...
  61. JEFFREY WALLACE TYNER; Fiscal Year: 2014
    ..Using this screen, we have identified a receptor tyrosine kinase, ROR1, that is uniquely and consistently overexpressed in all patients with t(1;19)-positive acute ..
  62. Susan E Waltz; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Ron receptor tyrosine kinase has recently been shown to be overexpressed and activated in a cohort of human cancers, with the most compelling data found in breast cancer...
  63. Role of c-Met in SCLC and Potential for Novel Therapy
    Ravi Salgia; Fiscal Year: 2012
    ..Previously, we had shown c-Met receptor tyrosine kinase can be an important therapeutic target in SCLC...
  64. Regulation of RNA Surveillance
    MILES FROME WILKINSON; Fiscal Year: 2012
    ..One-third of human genetic diseases are caused by PTC- containing mutant genes with nonsense or frameshift mutations...
  65. INTERCELLULAR SIGNALS AND INTESTINAL AGANGLIONOSIS
    Raj Kapur; Fiscal Year: 2000
    ..In mice and humans, intestinal aganglionosis has been associated with mutations in the RET an ET-B genes which encode receptors expressed by enteric neural precursors...
  66. RADIATION INDUCED THYROID CANCER
    Heinz Ulrich Weier; Fiscal Year: 2002
    ..Several tumors from this collection aberrantly expressed ret tyrosine kinase transcripts due to a ret/PTC1 or ret/PTC3 chromosomal rearrangements on chromosome 10...
  67. A Drosophila Model for MEN2 and Sporadic MTCs
    Ross Cagan; Fiscal Year: 2009
    ..Most patients diagnosed with MEN2 contain one of several dominantly-acting point mutations in the Ret receptor tyrosine kinase, resulting in ligand-independent activation of the receptor...
  68. Denver Prevention Training Center
    Mark W Thrun; Fiscal Year: 2010
    The Denver Sexually Transmitted Disease/Human Immunodeficiency Virus (STD/HIV) Prevention Training Center (PTC) Part I will provide clinical training for STD medical and laboratory services throughout Region VIII, including the states of ..
  69. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2010
    ..Recently, I discovered that a small population of DRG neurons that express the receptor tyrosine kinase Ret are the elusive RA mechanoreceptors and that Ret signaling is essential for their development...
  70. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..This application will focus on the unique role of the PTC tissue RAS, hypothesizing that local angiotensins amplify the effects of Stx in PTC, resulting in further injury...
  71. Treatment Retention Strategies in Transition Age Youth
    Maryann Davis; Fiscal Year: 2010
    ..The two TR interventions are: " Peer Therapy Coach (PTC);this web-based peer intervention that focuses on supporting participation in outpatient psychotherapy will be ..
  72. Development of ZnTe Powder Phosphor for Protein Crystallographic X-ray Detectors
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..Our phosphor will improve the performance of each of these substantially. PhosphorTech Corporation (PTC) is highly experienced in this area...