RBMS3

Summary

Gene Symbol: RBMS3
Description: RNA binding motif, single stranded interacting protein 3
Alias: RNA-binding protein
Species: human

Top Publications

  1. doi Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 71:6106-15. 2011
  2. ncbi Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins
    D Penkov
    Brookdale Center in the Department of Biochemistry, Mount Sinai School of Medicine, New York, NY, USA
    Gene 243:27-36. 2000
  3. pmc RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1
    Dillon Fritz
    Department of Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL 32306 4300, USA
    J Mol Biol 371:585-95. 2007
  4. ncbi Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
  5. pmc The essential yeast RNA binding protein Np13p is methylated
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Proc Natl Acad Sci U S A 93:13641-6. 1996
  6. pmc A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm
    J Flach
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 14:8399-407. 1994
  7. pmc Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription
    F D Schubot
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 10:1980-8. 2001
  8. ncbi The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting
    E M Ellis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
    Gene 132:175-83. 1993
  9. ncbi Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cells
    A Mas
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Horm Metab Res 30:118-22. 1998
  10. pmc The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Mol Biol Cell 17:14-24. 2006

Detail Information

Publications573 found, 100 shown here

  1. doi Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 71:6106-15. 2011
    ..In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24...
  2. ncbi Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins
    D Penkov
    Brookdale Center in the Department of Biochemistry, Mount Sinai School of Medicine, New York, NY, USA
    Gene 243:27-36. 2000
    ..element of the alpha2(I) collagen promoter (Box 5A) has led to the identification of a novel gene product (RBMS3)...
  3. pmc RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1
    Dillon Fritz
    Department of Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL 32306 4300, USA
    J Mol Biol 371:585-95. 2007
    ..Here, we show that expression of the RNA-binding protein RBMS3 is upregulated in the activation of HSCs and fibrotic livers...
  4. ncbi Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
    ..Substitution of conserved amino acid residues in the reverse transcriptase domain of TP2 completely abolished telomerase activity. We suggest that TP2 and hTR might represent the minimal catalytic core of human telomerase...
  5. pmc The essential yeast RNA binding protein Np13p is methylated
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Proc Natl Acad Sci U S A 93:13641-6. 1996
    ..Using a monoclonal antibody, 1E4, we have shown that the yeast NPL3 gene product Np13p, an essential RNA binding protein with repeated RGG motifs, is arginine-methylated in vivo...
  6. pmc A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm
    J Flach
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 14:8399-407. 1994
    ..This toxicity depends on the presence of series of unique repeats in the N terminus and localization to the nucleus. We suggest that the properties of Npl3 are consistent with it being involved in export of RNAs from the nucleus...
  7. pmc Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription
    F D Schubot
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 10:1980-8. 2001
    ..Based on the structure, we propose that the promoter specificity region is located on the mitochondrial RNA polymerase and that binding of sc-mtTFB indirectly mediates interaction of the core enzyme with the promoter site...
  8. ncbi The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting
    E M Ellis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
    Gene 132:175-83. 1993
    ..We have cloned and sequenced the wild-type allele of one of these genes (MTS1) and shown that it encodes a member of a family of RNA-binding proteins that is essential for growth...
  9. ncbi Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cells
    A Mas
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Horm Metab Res 30:118-22. 1998
    ..These domains could be targets for a RNA-binding protein induced by treatment with epinephrine producing a destabilization of IR mRNA in U-937 cells...
  10. pmc The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Mol Biol Cell 17:14-24. 2006
    ..We also demonstrate that Sam68 shuttles between the nucleus and the cytoplasm in secondary spermatocytes, suggesting that it may promote translation of specific RNA targets during the meiotic divisions...
  11. ncbi Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S and suppresses its translation in vitro
    Juxiang Yang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 68:853-9. 2003
    ..These data suggest that TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis. Moreover, the Gapds mRNA is the first mRNA shown to have a functional TB-RBP binding site in its 5' UTR...
  12. ncbi Molecular characterization of a TIA-1-like RNA-binding protein in cells derived from the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)
    Sayaka Muto
    Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo, Kyoto, Japan
    Biosci Biotechnol Biochem 73:648-56. 2009
    ....
  13. pmc The evolution of core proteins involved in microRNA biogenesis
    Dennis Murphy
    Bioinformatics, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, Collegeville, Pennsylvania 19426, USA
    BMC Evol Biol 8:92. 2008
    ....
  14. ncbi The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells
    Yoon Shin Cho
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:31514-23. 2004
    ..These subcellular distributions require interaction between TB-RBP and TRAX. We propose that the subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of TRAX and TB-RBP...
  15. pmc The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of phage Q beta RNA
    P A Kaminski
    Unité de Physiologie Cellulaire, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 91:4663-7. 1994
    ..A null mutant, constructed by disruption of nrfA, exhibited the same phenotype as the missense mutant. Thus, an additional factor can be added to the already complex system of nifA regulation in A. caulinodans...
  16. pmc Posttranscriptional repression of GacS/GacA-controlled genes by the RNA-binding protein RsmE acting together with RsmA in the biocontrol strain Pseudomonas fluorescens CHA0
    Cornelia Reimmann
    Département de Microbiologie Fondamentale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne Dorigny, Switzerland
    J Bacteriol 187:276-85. 2005
    ..The transcription and stability of both regulatory RNAs were strongly reduced in the rsmA rsmE double mutant. In conclusion, RsmA and RsmE together account for maximal repression in the GacS/GacA cascade of strain CHA0...
  17. ncbi RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo
    Javier G De Gaudenzi
    Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, CONICET UNSAM, 1650 San Martin, Provincia de Buenos Aires, Argentina
    J Biol Chem 278:18884-94. 2003
    ..Altogether, these results suggest that TcRBPs might be modulated in vivo, to favor or preclude the interaction with specific transcripts in a developmentally regulated manner...
  18. pmc Xlrbpa, a double-stranded RNA-binding protein associated with ribosomes and heterogeneous nuclear RNPs
    C R Eckmann
    Department of Cytology and Genetics, Institute of Botany, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 138:239-53. 1997
    ..data and the overall organization of the protein suggest that Xlrbpa is the Xenopus homologue of human TAR-RNA binding protein (TRBP), a protein isolated by its ability to bind to human immunodeficiency virus (HIV) TAR-RNA...
  19. ncbi Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 409:389-98. 2008
    ....
  20. doi RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma
    Yung Ming Jeng
    Graduate Institute of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 48:1118-27. 2008
    ..Microarray analysis revealed that IMP3 depletion was associated with downregulation of multiple genes involved in tumor invasion...
  21. doi Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cel
    Canan Doğanlı
    Department of Medical Biochemistry, Aarhus University, Aarhus C, Denmark
    DNA Cell Biol 29:713-27. 2010
    ..Despite the lack of a conserved nuclear localization signal, the C. elegans ZFR-GFP fusion protein also displayed an intranuclear localization in the 2-cell mouse embryo...
  22. pmc The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro
    Jinwoo Ahn
    Department of Structural Biology, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Retrovirology 7:40. 2010
    Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) and influences the efficiency of viral reverse transcription (Lemay et al...
  23. pmc Rrp5p, a trans-acting factor in yeast ribosome biogenesis, is an RNA-binding protein with a pronounced preference for U-rich sequences
    Paulo de Boer
    Section of Biochemistry and Molecular Biology, FEW, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    RNA 12:263-71. 2006
    ..cerevisiae spacer. The implications for the role of Rrp5p in yeast ribosome biogenesis are discussed...
  24. pmc Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1
    Y W Park
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:6694-9. 1999
    ....
  25. pmc Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
    Mark E Gill
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7443-8. 2011
    ..In C57BL/6 mice, Dazl is required for licensing. Licensing serves as a gateway from the embryonic processes shared between the sexes--germ cell specification and migration--to the sex-specific pathways of oogenesis and spermatogenesis...
  26. pmc Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis
    Peng Yuan Wang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 426:293-306. 2010
    ..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs...
  27. pmc rsmC of the soft-rotting bacterium Erwinia carotovora subsp. carotovora negatively controls extracellular enzyme and harpin(Ecc) production and virulence by modulating levels of regulatory RNA (rsmB) and RNA-binding protein (RsmA)
    Y Cui
    Plant Sciences Unit, University of Missouri, Columbia, Missouri 65211, USA
    J Bacteriol 181:6042-52. 1999
    ..betavasculorum, and E. carotovora subsp. carotovora. These findings collectively support the idea that rsmA and rsmB expression in these plant pathogenic Erwinia species is controlled by RsmC or a functional homolog of RsmC...
  28. ncbi Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons
    Naila Ben Fredj
    Neurodégénérescence et Plasticité, INSERM EMI 01 08, Institut National de la Sante et de la Recherche Medicale, Pavillon de Neurologie, Centre Hospitalier Universitaire, 38043 Grenoble, France
    J Cell Sci 117:1079-90. 2004
    ..These results support the possible involvement of Sam68 in the activity-dependent regulation of dendritic mRNAs...
  29. pmc ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding protein
    Yaya Cui
    Department of Plant Microbiology and Pathology, University of Missouri, Columbia, 65211, USA
    J Bacteriol 187:4792-803. 2005
    ..carotovora have shown that AHL deficiency causes the production of high levels of RsmA, an RNA binding protein that functions as a global negative regulator of extracellular enzymes and proteins and secondary ..
  30. pmc RNA binding protein with multiple splicing: a new marker for retinal ganglion cells
    Jacky M K Kwong
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Invest Ophthalmol Vis Sci 51:1052-8. 2010
    To characterize expression of the RNA binding protein (RBPMS) in the retina as a specific marker for retinal ganglion cells (RGCs).
  31. ncbi Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrB
    T Romeo
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
    Mol Microbiol 29:1321-30. 1998
    ..The presence of csrA homologues in phylogenetically diverse species further suggests that this novel kind of regulatory system is likely to play a broad role in modulating eubacterial gene expression...
  32. pmc The Arabidopsis thaliana double-stranded RNA binding protein DRB1 directs guide strand selection from microRNA duplexes
    Andrew L Eamens
    Commonwealth Scientific and Industrial Research Organisation Plant Industry, Canberra, Australian Capital Territory 2601, Australia
    RNA 15:2219-35. 2009
    In Arabidopsis thaliana (Arabidopsis), DICER-LIKE1 (DCL1) functions together with the double-stranded RNA binding protein (dsRBP), DRB1, to process microRNAs (miRNAs) from their precursor transcripts prior to their transfer to the RNA-..
  33. pmc Bovine coronavirus nonstructural protein 1 (p28) is an RNA binding protein that binds terminal genomic cis-replication elements
    Kortney M Gustin
    Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 83:6087-97. 2009
    ..These results together indicate that nsp1 is an RNA-binding protein that may function to regulate viral genome translation or replication but not by binding SLV-VI within its own coding region...
  34. pmc RNA-binding protein TIAR is essential for primordial germ cell development
    A R Beck
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:2331-6. 1998
    ..TIAR-deficient mice thus provide a model system to study molecular mechanisms of PGC development and possibly the basis for some forms of idiopathic infertility...
  35. ncbi Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast
    Naoko Mauchi
    Department of Molecular Cell Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai, Tsukuba, Japan
    Cell Struct Funct 35:95-105. 2010
    ..Our results suggest that MTL1 mRNA bears a cis-acting element involved in destabilization by the decapping enzyme and the 5'-3' exonuclease, and Khd1p stabilizes MTL1 mRNA through binding to this element...
  36. pmc Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production
    Helen S Christensen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Virol 81:5121-31. 2007
    ..silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components...
  37. doi Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmology 116:1502-9. 2009
    ....
  38. pmc HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells
    Qintong Li
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Nucleic Acids Res 35:2503-12. 2007
    ..Our study illuminates novel properties of HEXIM1 both in vitro and in vivo, and suggests that HEXIM1 may be involved in other nuclear and cytoplasmic processes besides controlling P-TEFb...
  39. ncbi Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification
    Y P Liu
    Department of Chemistry, Rutgers State University of New Jersey 08855 0939, USA
    Biol Signals 6:166-74. 1997
    ..Our study also suggests the possibility of using a gel mobility shift assay for eIF-5A-RNA binding as a functional assay for deoxyhypusine and hypusine formation...
  40. ncbi DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
    H A Drabkin
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
    Oncogene 18:2589-97. 1999
    DEF-3(g16/NY-LU-12) encodes a novel RNA binding protein isolated by positional cloning from an SCLC homozygous deletion region in 3p21.3 and, in parallel, as a differentially expressed gene during myelopoiesis from FDCPmix-A4 cells...
  41. doi RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases
    Dengfeng Cao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 24:288-96. 2011
    ..03) and was therefore more sensitive. For primary extragonadal yolk sac tumors, combining LIN28 and SALL4 can achieve a higher diagnostic sensitivity than either alone...
  42. ncbi The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 15:1525-38. 2006
    ..We propose that this novel cellular partner for FMRP escorts FMRP-containing mRNP from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation...
  43. ncbi Ethanol inhibited apoptosis-related RNA binding protein, Napor-3 gene expression in the prenatal rat brain
    Nibedita Naha
    Division of Life Science, Applied Life Science BK 21, College of Natural Science, Gyeongsang National University, Jinju, South Korea
    Med Sci Monit 15:BR6-12. 2009
    ..The objective of the present study was to observe whether maternal ethanol exposure can alter gene expression pattern in mother and in fetus during mid and late prenatal stage...
  44. ncbi Part of Xenopus translin is localized in the centrosomes during mitosis
    A Castro
    Centre de Recherches de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, Montpellier Cedex 5, 34293, France
    Biochem Biophys Res Commun 276:515-23. 2000
    ..Interestingly, part of X-translin underwent a remarkable redistribution throughout mitosis and associated with centrosomes, which may suggest a new unknown role for this protein in cell cycle...
  45. pmc A family of cold-regulated RNA-binding protein genes in the cyanobacterium Anabaena variabilis M3
    N Sato
    Laboratory of Life Science, Tokyo Gakugei University, Japan
    Nucleic Acids Res 23:2161-7. 1995
    ..Gel-filtration assay showed that all of the Rbp proteins have higher affinities to poly(G) and poly(U) than to poly(A) and poly(C)...
  46. doi Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors
    Kanako Susaki
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Exp Eye Res 88:347-55. 2009
    ..Studying the regulation of Msi1 and the target RNAs of Msi1 in photoreceptors and RPE cells might contribute to fundamental and clinical studies of retinal degeneration...
  47. doi Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt
    Jun Kaneko
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    Neurosci Lett 450:252-7. 2009
    ..All together, it is probable that Msi1 is one of the essential factors that need to be regulated in retinal regeneration...
  48. ncbi Functional characterization of a glycine-rich RNA-binding protein 2 in Arabidopsis thaliana under abiotic stress conditions
    Joo Y Kim
    Department of Plant Biotechnology, Agricultural Plant Stress Research Center and Biotechnology Research Institute, College of Agriculture and Life Sciences, Chonam National University, Gwangju 500 757, Korea
    Plant J 50:439-51. 2007
    ....
  49. ncbi Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    Christine Hostetter
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
    Cancer Biol Ther 7:1496-506. 2008
    ..We found that inhibition of JNK, a member of the MAPK family, decreases cytoplasmic accumulation of the RNA binding protein HuR...
  50. pmc Predicting RNA-binding residues from evolutionary information and sequence conservation
    Yu Feng Huang
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
    BMC Genomics 11:S2. 2010
    ..The ability to computationally predict RNA-binding residues in a RNA-binding protein can help biologists reveal important site-directed mutagenesis in wet-lab experiments...
  51. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
  52. pmc Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences
    Duk Hee Kang
    Division of Nephrology, Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Yangcheon Gu, Seoul 158 710, Republic of Korea
    Int J Mol Med 32:1187-94. 2013
    ..To our knowledge, this study demonstrates for the first time that α-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence...
  53. ncbi Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development
    M Nakamura
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Neuron 13:67-81. 1994
    ..We propose that the msi protein regulates sensillum development by controlling the expression of target genes at the posttranscriptional level...
  54. ncbi Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis
    Amanda Norvell
    Department of Biology, The College of New Jersey, PO Box 7718, Ewing, NJ 08628 0718, USA
    Dev Genes Evol 215:340-9. 2005
    ..These results also place Sqd among an emerging class of proteins, including such other members as Bruno (Bru) and Hrb27C/Hrp48, which function in multiple aspects of both grk and osk mRNA regulation during Drosophila oogenesis...
  55. ncbi New horizons for VEGF. Is there a role for nuclear localization?
    Flavio Lejbkowicz
    Vascular Research Laboratory, Rappaport Institute for Medical Research, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Acta Histochem 106:405-11. 2005
    ..These results indicate that VEGF may have a nuclear function, especially during hypoxia...
  56. pmc Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes
    Ji Ann Lee
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 89:113-28. 2016
    Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a candidate gene for autism spectrum disorders...
  57. doi Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth
    Nicolas Fossat
    Embryology Unit, Children s Medical Research Institute, Westmead, New South Wales, 2145, Australia
    Genesis 54:115-22. 2016
    Rbm47 encodes a RNA binding protein that is necessary for Cytidine to Uridine RNA editing. Rbm47(gt/gt) mutant mice that harbor inactivated Rbm47 display poor viability...
  58. pmc Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding
    E K Chan
    Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, CA 92037
    Nucleic Acids Res 17:2233-44. 1989
    ..The data suggest that SS-B/La belongs to a large family of RNA-binding proteins which includes heterogeneous nuclear RNPs, nucleolin, mRNA polyadenylate binding protein, and small nuclear RNPs...
  59. ncbi An RNA-binding protein, AtRBP1, is expressed in actively proliferative regions in Arabidopsis thaliana
    M Suzuki
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Plant Cell Physiol 41:282-8. 2000
    ..Considering the specificity of the expression, AtRBP1 may be required in the progress of cell proliferation...
  60. ncbi Mouse staufen genes are expressed in germ cells during oogenesis and spermatogenesis
    P T Saunders
    Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, UK
    Mol Hum Reprod 6:983-91. 2000
    The Drosophila melanogaster staufen gene encodes an RNA binding protein (Dm Stau) required for the localization and translational repression of mRNAs within the Drosophila oocyte...
  61. pmc Purification of Messenger Ribonucleoprotein Particles via a Tagged Nascent Polypeptide
    Diana P Inchaustegui Gil
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    PLoS ONE 11:e0148131. 2016
    ....
  62. pmc Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels
    Vincenzo A Gennarino
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Jan and Dan Duncan Neurological Research Institute at Texas Children s Hospital, Houston, TX 77030, USA
    Cell 160:1087-98. 2015
    ..These results demonstrate the importance of studying post-transcriptional regulation of disease-driving proteins to reveal factors underlying neurodegenerative disease...
  63. pmc Transposable elements in TDP-43-mediated neurodegenerative disorders
    Wanhe Li
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e44099. 2012
    ..Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases...
  64. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
    ..P4) receptor membrane component-1 (PGRMC1) and its binding partner, plasminogen activator inhibitor 1 RNA binding protein (PAIRBP1) are thought to form a complex that functions as membrane receptor for P4...
  65. doi Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
    Ilse Gantois
    Laboratory of Biological Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Leuven, Belgium
    Behav Brain Res 239:72-9. 2013
    ..FMRP is an RNA binding protein involved in the regulation of translation of specific target mRNAs upon stimulation of metabotropic ..
  66. pmc RNA remodeling by bacterial global regulator CsrA promotes Rho-dependent transcription termination
    Nara Figueroa-Bossi
    CNRS UPR3404, Centre de Genetique Moleculaire, Gif sur Yvette 91198, France, affilié à l Université Paris Sud XI, Orsay 91405, France
    Genes Dev 28:1239-51. 2014
    ..These findings establish a new paradigm for bacterial gene regulation in which remodeling of the nascent transcript by a regulatory protein promotes Rho-dependent transcription attenuation...
  67. doi Rice PLASTOCHRON genes regulate leaf maturation downstream of the gibberellin signal transduction pathway
    Manaki Mimura
    Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, 113 8657, Japan
    Planta 235:1081-9. 2012
    ..These results indicate that both PLA1 and PLA2 act downstream of the GA signal transduction pathway to regulate leaf development...
  68. ncbi Solution NMR structure of ribosome-binding factor A (RbfA), a cold-shock adaptation protein from Escherichia coli
    Yuanpeng Janet Huang
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA
    J Mol Biol 327:521-36. 2003
    ..coli operon. Structural and functional similarities between RbfA, NusA, and other bacterial type II KH domains suggest previously unsuspected evolutionary relationships between these cold-shock associated proteins...
  69. pmc Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R
    Matthew L Kraushar
    Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ 08854
    Proc Natl Acad Sci U S A 111:E3815-24. 2014
    ..Our study identifies a crucial role for HuR in neocortical development as a translational gatekeeper for functionally related mRNA subgroups and polysomal protein specificity. ..
  70. ncbi Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice
    J M Schumacher
    Department of Genetics, University of Washington, Seattle 98195, USA
    Biol Reprod 59:69-76. 1998
    ..These results suggest that SPNR, in addition to its function as an RNA-binding protein, is also a bona fide MAP...
  71. pmc Human U1 snRNA forms a new chromatin-associated snRNP with TAF15
    Laure Jobert
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, CNRS UMR 7104, INSERM U 964, Universite de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France
    EMBO Rep 10:494-500. 2009
    ..A demonstration that human U1 snRNA forms at least two structurally distinct snRNPs supports the idea that the U1 snRNA has many nuclear functions...
  72. ncbi Comparative transcriptome profiling of near-isogenic barley (Hordeum vulgare) lines differing in the allelic state of a major grain protein content locus identifies genes with possible roles in leaf senescence and nitrogen reallocation
    Aravind K Jukanti
    Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT 59717, USA
    New Phytol 177:333-49. 2008
    ..Functional characterization of candidate genes identified by this research may contribute to our understanding of the molecular network underlying leaf senescence and nitrogen reallocation...
  73. doi High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors
    Ilona Hapkova
    Inserm U1046, Universite Montpellier 1, Universite Montpellier 2, Montpellier, France
    Exp Mol Pathol 94:314-21. 2013
    ..In conclusion, RBPMS2 is up-regulated in GISTs compared to normal adult gastrointestinal tissues, indicating that RBPMS2 might represent a new diagnostic marker for GISTs and a potential target for cancer therapy...
  74. ncbi [Construction and analysis of the SSH library with the resistant wheat near-isogenic line and its susceptible parent infected by Puccinia striiformis Westend. f. sp. tritici]
    Wei Shu
    Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Yi Chuan 33:1011-6. 2011
    ..were detected, and their putative products were leucine-rich repeat protein, catalase, thioredoxin H-type, RNA binding protein, ascorbate peroxidase, and heat shock protein, respectively...
  75. ncbi Stimulation of pri-miR-18a Processing by hnRNP A1
    Gracjan Michlewski
    Adv Exp Med Biol 700:28-35. 2011
    ....
  76. ncbi Thymidylate synthase as a translational regulator of cellular gene expression
    Jun Liu
    Department of Medicine and Pharmacology, Yale Cancer Center, Yale University School of Medicine, USA
    Biochim Biophys Acta 1587:174-82. 2002
    ..from our laboratory have shown that the folate-dependent enzyme, thymidylate synthase (TS), functions as an RNA binding protein. There is evidence that TS, in addition to interacting with its own TS mRNA, forms a ribonucleoprotein ..
  77. pmc Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation
    Hideaki Nakamura
    Research Institute, National Center for Geriatrics and Gerontology, 35 Gengo, Moriokacho, Obu, Aichi 474 8511, Japan
    Mol Cell Biol 31:1997-2009. 2011
    ....
  78. doi RNA-protein interaction mediating post-transcriptional regulation in the circadian system
    Jan C Schöning
    Department of Molecular Cell Physiology, University of Bielefeld, Bielefeld, Germany
    Methods Mol Biol 479:337-51. 2009
    ..Here we describe the analysis of RNA-protein interaction in vitro employing recombinant RNA-binding protein and 32P-labelled in vitro transcripts or synthetic RNA oligoribonucleotides comprising the binding site under study...
  79. doi Macro role(s) of microRNAs in fragile X syndrome?
    Xuekun Li
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia, 30322, USA
    Neuromolecular Med 11:200-7. 2009
    ..Here we review the current state of knowledge about the microRNA pathway in neural development and the emergence of possible roles for miRNAs in FXS...
  80. ncbi Helix-destabilizing properties of the human single-stranded DNA- and RNA-binding protein Puralpha
    N Darbinian
    Laboratory of Molecular Neurovirology, Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 N 12th Street, 015 96, Philadelphia, PA 19122, USA
    J Cell Biochem 80:589-95. 2001
    ..Taken together, these studies demonstrate that Puralpha possesses helix-destabilizing activity and that this activity maps to and correlates with its ability to interact with DNA...
  81. pmc Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
    Nicole Appel
    Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
    PLoS Pathog 4:e1000035. 2008
    ..Since domain III of NS5A is one of the most variable regions in the HCV genome, the results suggest that viral isolates may differ in their level of virion production and thus in their level of fitness and pathogenesis...
  82. ncbi Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts
    Lidia Vasiljeva
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Cell 21:239-48. 2006
    ..We find that the RNA binding protein Nrd1, complexed with its partners Nab3, Sen1, and cap binding complex, physically interacts with the ..
  83. doi The Drosophila RNA-binding protein Lark is required for localization of Dmoesin to the oocyte cortex during oogenesis
    Gerard P McNeil
    Department of Biology, York College, The City University of New York, Jamaica, NY 11451, USA
    Dev Genes Evol 219:11-9. 2009
    ..Thus, our results provide evidence that Dmoe RNA is a target of Lark during oogenesis and that it likely regulates either the splicing or translation of this RNA...
  84. pmc Regulatory network controlling extracellular proteins in Erwinia carotovora subsp. carotovora: FlhDC, the master regulator of flagellar genes, activates rsmB regulatory RNA production by affecting gacA and hexA (lrhA) expression
    Yaya Cui
    Division of Plant Sciences, 108 Waters Hall, University of Missouri, Columbia, MO 65211, USA
    J Bacteriol 190:4610-23. 2008
    ..carotovora subsp. carotovora. Our observations for the first time establish a regulatory connection between FlhDC, HexA, GacA, and rsmB RNA in the context of the exoprotein production and virulence of E. carotovora subsp. carotovora...
  85. doi The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death
    Sven Wellmann
    Clinic of Neonatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Pediatr Res 67:35-41. 2010
    ..Together, RBM3 is a critical factor providing cellular survival advantages in an adverse microenvironment presumably by restoring translation efficacy...
  86. pmc The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon
    Yilei Liu
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 5:e1000707. 2009
    ..In addition, we identified a high-affinity binding site for hnRNP G-T protein, showing it is also a sequence-specific RNA binding protein.
  87. pmc The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1
    Tariq A Tahir
    Departments of Cardiovascular Sciences and Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    Cell Signal 26:1379-84. 2014
    ..The ability to rapidly upregulate UCP2 protein expression may be important in protecting endothelial cells from excessive generation of potentially damaging reactive oxygen species...
  88. pmc FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
    Manuela Neumann
    Institute of Neuropathology, Schmelzbergstr 12, 8091 Zurich, Switzerland
    Brain 134:2595-609. 2011
    Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several ..
  89. pmc Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR
    Marija Mihailovic
    Gene Regulation Programme, Centre for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
    RNA 18:53-64. 2012
    ..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner...
  90. pmc starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data
    Jun Hao Li
    RNA Information Center, Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou 510275, PR China
    Nucleic Acids Res 42:D92-7. 2014
    ..This study will greatly expand our understanding of ncRNA functions and their coordinated regulatory networks...
  91. pmc Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering
    Jae Hoon Jung
    Department of Chemistry, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 287:16007-16. 2012
    ..We propose that the FCA-miR172 regulon provides an adaptive strategy that fine tunes the onset of flowering under fluctuating ambient temperature conditions...
  92. pmc Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation
    Lei Lei Jiang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 320 Yue Yang Road, Shanghai 200031, China
    Sci Rep 6:23928. 2016
    TDP-43 is a DNA/RNA binding protein associated with TDP-43 proteinopathies. Many mutations have been identified in the flexible C-terminal region, which is implicated in the disease pathology...
  93. pmc The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein
    Braden M Roth
    From the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425
    J Biol Chem 288:26785-99. 2013
    ..Thus, specific RNA processing is likely facilitated by preformed DGCR8-Drosha heterodimers that can discriminate between authentic substrates and other hairpins. ..
  94. pmc MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation
    Louis Düring
    Department of Biology, Copenhagen Biocenter, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e44373. 2012
    ..Mrn1 is an RNA binding protein that localizes both to the nucleus and cytoplasm...
  95. pmc Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice
    Marie Cibois
    Universite de Rennes 1, Universite Europeenne de Bretagne, Biosit, Rennes, France
    PLoS ONE 7:e46337. 2012
    ..Post-transcriptional controls of gene expression play important roles in this process but the molecular actors that underlie them are poorly known...
  96. pmc Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2
    Blair B Madison
    Division of Gastroenterology, Washington University School of Medicine, Saint Louis, Missouri, United States of America Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Genet 11:e1005408. 2015
    ..In aggregate, we conclude that Let-7 depletion drives a stem cell phenotype and the development of intestinal cancer, primarily via Hmga2. ..
  97. doi MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
    Mikihito Shibata
    Laboratories for Vertebrate Body Plan and Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 31:3407-22. 2011
    ..Pallial/subpallial boundary shifted dorsally, and the ventral pallium was lost. Corridor was malformed, and thalamocortical and corticofugal axons were misrouted in the miR-9-2/3 double mutants...
  98. pmc miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries
    Bindu Menon
    Departments of Obstetrics Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0617
    Endocrinology 156:3370-80. 2015
    ..to a supraphysiological concentration of its ligands through a posttranscriptional mechanism involving an RNA binding protein designated as LHR mRNA binding protein (LRBP)...
  99. pmc Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium
    Kristina Jonas
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Environ Microbiol 12:524-40. 2010
    ..Altogether, our data reveal that the concerted and complex regulation of several genes encoding GGDEF/EAL domain proteins allows CsrA to control the motility-sessility switch in S. Typhimurium at multiple levels...
  100. pmc Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1
    Marcelo R Vargas
    Departamento de Neurobiologia Celular y Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Neurosci Res 86:3515-25. 2008
    ..Down-regulated genes included the insulin-like growth factor-1 receptor (Igf-1r) and the RNA binding protein ROD1. Rod1 was also found down-regulated in purified motor neurons expressing SOD1(G93A)...
  101. pmc Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS
    Patricia S Estes
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Hum Mol Genet 20:2308-21. 2011
    ....

Research Grants103 found, 100 shown here

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Competing roles of microRNAs and RNA-binding proteins in drug addiction
    NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013
    ..Our research suggests that the RNA binding protein HuD and the microRNA miR-495 play opposite roles in the control of addiction-related gene expression and ..
  3. Impact of miR-495 vs. HuD in the Control of Addiction-Related Genes and Behavior
    NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013
    ..A better understanding of these regulatory mechanisms is a pre-requisite for the application of these new tools in addiction research and ultimately in the treatment of this disorder. ..
  4. Fragile X Mental Retardation Protein translation regulator function: interactions
    MIHAELA R MIHAILESCU; Fiscal Year: 2013
    ..FMRP is an RNA binding protein involved in the transport and translation regulation of specific messenger RNA (mRNA) targets...
  5. Dissecting the molecular basis of fragile X syndrome in Drosophila
    Peng Jin; Fiscal Year: 2011
    ..abstract_text> ..
  6. Regulation of a Novel Trypanosome RNA Binding Protein by Arginine Methylation
    Kaylen Lott; Fiscal Year: 2013
    ..Overall, the proposed experiments will provide insight into the functions of an essential RBP in T. brucei and elucidate how arg methylation can modulate these functions. ..
  7. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    ..This research tests the hypothesis that large RNP granules play a protective role in maintaining oocyte viability and fertility and may be relevant to understanding the basis for infertility that occurs as women age. ..
  8. Location: Its role in protein-RNA contact during trypanosome gene regulation
    Vivian Bellofatto; Fiscal Year: 2013
    ..brucei. This exploratory, two-year project is grounded in preliminary data, in a recent publication from our laboratory, preliminary data and complementary in vivo molecular genetic and in vitro biochemical approaches. ..
  9. Mechanisms Of RNA-Binding Protein-Mediated Apoptosis In Oral Mucositis
    VISWANATHAN PALANISAMY; Fiscal Year: 2013
    ..Thus, our data will provide a foundation for understanding the role of HuR in oral mucositis-associated gene regulation and will be pivotal for future studies into HuR-associated oral diseases. ..
  10. Mechanism of p53-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2013
    ....
  11. A Neural Development mRNA Decay Network
    Michael Cleary; Fiscal Year: 2013
    ..This work will generate a comprehensive and predictive network map of neural mRNA decay dynamics, thus filling a significant gap in current models of gene expression during neural development. ..
  12. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2013
    The broad goal of the project is to understand the mechanisms by which RNA binding protein RBM3 regulates gene expression at the posttranscriptional level of mRNA stability and translation in cancer cells...
  13. Cytoplasmic Functions of Rbfox1, a Candidate Autism Gene
    Kelsey C Martin; Fiscal Year: 2013
    ..For example, mutations in Fragile X Mental Retardation protein, an RNA binding protein involved in RNA trafficking and translational regulation at the synapse, represent the most common single ..
  14. Encyclopedia of C elegans 3'UTRS and their regulatory elements
    Fabio Piano; Fiscal Year: 2011
    ..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
  15. Circadian regulation of microRNA biogenesis and function
    Peter W Vanderklish; Fiscal Year: 2012
    ..In light of emerging data that disruptions in circadian rhythm and miRNA expression underlie many disease states, our studies should provide important insights into disease-related processes of the nervous system. ..
  16. MOLECULAR CLONING OF THE FRAGILE X SITE
    Stephen T Warren; Fiscal Year: 2011
    ..Deep fundamental knowledge of a disease is the best course toward eventual therapeutics. ..
  17. Regulation of microRNA biogenesis in stem cells
    Richard I Gregory; Fiscal Year: 2013
    ..These studies are relevant to the treatment of cancer, diabetes, developmental disorders and numerous degenerative diseases. ..
  18. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..Aim 2: To test the hypothesis that the RNA binding protein HuR regulates the ontogeny of ASBT via changes in mRNA stability...
  19. A novel therapy for HER2 positive hormone refractory breast cancer
    Anne W Hamburger; Fiscal Year: 2010
    ..As several independent groups have demonstrated that EBP1 is both a DNA and RNA binding protein, we will examine effects on EBP1 on ErbB2 transcription and post-transcriptional events...
  20. A role for mRNA transport and local translation in podocytes
    Valérie A Schumacher; Fiscal Year: 2013
    ..Two major foci will be on the role of the RNA binding protein Staufen 2 in regulating mRNA localization in podocytes and the role of Staufen 2 and Staufen 2-associated ..
  21. PHOSPHOPEPTIDE METABOLISM IN ADIPOCYTES
    Joseph Avruch; Fiscal Year: 2013
    ..Among them is an RNA binding protein IMP2, first discovered by its ability to bind to an IGF2 mRNA expressed primarily in fetal life, whose ..
  22. Roles of RNA helicase and ribosomal biogenesis in normal and diseased muscle
    Vandana Gupta; Fiscal Year: 2013
    ..Genetic mapping in osoi fish identified a 20 base pair deletion in a novel DEAD-box RNA helicase, a RNA binding protein, resulting in a frameshift mutation. Dr...
  23. Coordination of metabolism and virulence during infection
    Tony Romeo; Fiscal Year: 2013
    ..CsrA is an RNA binding protein that regulates mRNA translation and stability...
  24. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..target AU-rich sequences, and requires LFA-1 engagement-induced nuclear-to-cytoplasmic translocation of the RNA binding protein HuR...
  25. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ....
  26. RNA Binding Protein CUGBP2 in Intestinal Epithelium
    Shrikant Anant; Fiscal Year: 2010
    ..provided by applicant): The broad goal of this application is to understand the mechanisms by which RNA binding protein CUGBP2 regulates gene expression at the posttranscriptional level of mRNA stability and translation in ..
  27. Post-transcriptional control of inflammatory gene expression
    Thomas A Hamilton; Fiscal Year: 2013
    ..This proposal is focused upon understanding the mechanisms through which IL-17 (and other stimuli) controls degradation of specific inflammation related messenger RNAs and thereby modulates aspects of inflammatory response. ..
  28. Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1
    Blanche Capel; Fiscal Year: 2013
    ..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..
  29. The role of CshA and CshB in selective mRNA protection in S. aureus
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2013
    ..Accordingly, MazFsa and "specific RNA binding proteins" represent novel targets for antibiotic development. As TA systems, DEAD-box and other RNA binding proteins are common in prokaryotes, our results may apply to other pathogens. ..
  30. Posttranscriptional Gene Regulation in Asthma
    Ulus Atasoy; Fiscal Year: 2010
    ..Our central hypothesis is that the RNA binding protein, HuR, is coordinately regulating IL-4 and IL-13 cytokine genes during allergen driven asthma...
  31. Control of Oocyte Maturation in C. elegans
    DAVID IRWIN GREENSTEIN; Fiscal Year: 2013
    ..The small roundworm C. elegans is an established model for studying the hormonal control of meiosis. These studies will define the signaling mechanisms controlling female meiosis and provide insights into the origin of meiotic errors. ..
  32. REGULATION OF SYNAPSE ELIMINATION BY FMRP
    JULIA RIVES WILKERSON; Fiscal Year: 2011
    ..The results of these experiments may lead to the development of new therapies for autism and mental retardation disorders. ..
  33. A structure-function analysis of let-7g miRNA regulation by Lin28
    CHRISTINA ROSE MOZES; Fiscal Year: 2012
    ....
  34. RNA binding proteins and intestinal stem cells
    Anand Venugopal; Fiscal Year: 2013
    ..RNA binding motif 3 (RBM3) is an RNA binding protein that is expressed in the intestinal epithelial cells...
  35. HuR in Allergic Asthma
    Ulus Atasoy; Fiscal Year: 2012
    ..Our hypothesis is that the RNA binding protein, HuR, is coordinately regulating Th2 polarization and cytokine gene expression in allergic airway ..
  36. Mechanisms of mGluR5 function and dysfunction in mouse autism models
    Kimberly M Huber; Fiscal Year: 2013
    ..Fmr1 encodes a neuronal RNA binding protein, Fragile X Mental Retardation Protein (FMRP) 6...
  37. METABOLIC CONTROL OF PROINSULIN BIOSYNTHESIS TRANSLATION
    Christopher J Rhodes; Fiscal Year: 2013
    ..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
  38. The toxicity of the RNA CGG repeats in FXTAS
    Lubov T Timchenko; Fiscal Year: 2013
    ..The identification of the early toxic events which trigger progression of FXTAS will provide a basis for the development of the therapeutic approaches for FXTAS. ..
  39. Cell-specific RNA Targets of the Fragile X Mental Retardation Protein Family
    Jennifer C Darnell; Fiscal Year: 2013
    ....
  40. Post-Transcriptional Regulation of Periodontal Dise
    Keith L Kirkwood; Fiscal Year: 2013
    ..These studies will establish the role of a key RNA binding protein in experimental models and human periodontitis...
  41. The role of microRNA in cardiac cell death
    Maha Abdellatif; Fiscal Year: 2013
    ..2) Examine the mechanisms of function of miR-21 and its target genes, FasL and PTEN, in cardiac myocytes. 3) Study the function of miR-21 and its regulation in vivo. ..
  42. Investigation of Gemin5 in Coordinated mRNA Regulation
    DANIEL BATTLE; Fiscal Year: 2013
    ..Finally, we will define how Gemin5 controls gene expression in SMA by using neuronal cells with reduced SMN and an SMA mouse model. ..
  43. RNA-binding Protein HuR in Allergic Inflammation
    Cristiana Stellato; Fiscal Year: 2009
    ..abstract_text> ..
  44. Presynaptic Fragile X Proteins
    Michael R Akins; Fiscal Year: 2011
    ..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
  45. TELOMERASE IN DEVELOPMENT, SENESCENCE AND NEOPLASIA
    RONALD ANTHONY DEPINHO; Fiscal Year: 2012
    ..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
  46. TELOMERASE IN DEVELOPMENT, SENESCENCE AND NEOPLASIA
    RONALD ANTHONY DEPINHO; Fiscal Year: 2013
    ..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
  47. Neuronal dysfunction in fragile X spectrum disorders
    Abigail Renoux; Fiscal Year: 2013
    ....
  48. METABOLIC CONTROL OF PROINSULIN BIOSYNTHESIS TRANSLATION
    Christopher Rhodes; Fiscal Year: 2009
    ..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
  49. Analysis of MEF2 in Cortical Connectivity and Autism-Associated Behaviors
    ADAM JOHN HARRINGTON; Fiscal Year: 2013
    ..With synapse elimination defects observed in autism and FXS, we believe that our studies will significantly enhance our understanding of the neurobiology in these complex diseases. ..
  50. Translational Regulation of Adult Neural Stem Cells
    Xinyu Zhao; Fiscal Year: 2013
    ..learning and present us a unique opportunity for understanding the specific roles and functional impact of RNA binding protein- mediated translational regulation in postnatal/adult neurogenesis and learning disabilities...
  51. Role of RNA Binding Proteins in BCR/ABL Leukemogenesis
    Danilo Perrotti; Fiscal Year: 2012
    ..If the proposed studies will determine modulation of RNA binding protein expression and function antagonize disease progression and efficiently induce apoptosis in the leukemia-..
  52. RNA-binding protein CRD-BP in melanocyte biology
    Vladimir S Spiegelman; Fiscal Year: 2013
    ..2. To delineate the mechanism(s) of CRD-BP regulation by hypoxia. 3. To analyze the (patho)physiologic significance of CRD-BP regulation by hypoxia in melanocytes. ..
  53. Mechanisms of MEF2-dependent synapse elimination
    CARLY FENWICK HALE; Fiscal Year: 2013
    ....
  54. The age-dependence of synaptic deficits in 22q11.2 deletion syndrome mouse models
    Laurie R Earls; Fiscal Year: 2013
    ..Dgcr8 is a double-stranded RNA binding protein important for microRNA biosynthesis...
  55. Presynaptic Fragile X Proteins
    Michael R Akins; Fiscal Year: 2013
    ..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
  56. Gene-centered protein-RNA interaction mapping
    ALBERTHA JOHANNA WALHOUT; Fiscal Year: 2012
    ..RAPID is based on translation and mimics endogenous RNA binding protein activity...
  57. Structural and Mechanistic Studies of Regulation of let-7 biogenesis by Lin28'
    Piotr Sliz; Fiscal Year: 2013
    ..Finally, elucidating how Lin28 inhibits microRNA processing will also provide new information on the mechanism of central events in microRNA processing. ..
  58. The Regulation of UPA and UPAR in Human Carcinoma Cells
    Shuang Huang; Fiscal Year: 2010
    ..Also, gaining further understanding of the novel role of SECp43 in repressing uPA expression may lead to the development of a novel therapeutic approach to suppress tumor growth and metastasis. ..
  59. Small RNAs in Stem Cell Differentiation and Neural Development
    Robert H Blelloch; Fiscal Year: 2010
    ..This model is based on the conditional deletion of the RNA binding protein DGCR8, which is required for the processing of pri- to pre-microRNAs...
  60. Messenger RNA stability in myotonic dystrophy
    Carol J Wilusz; Fiscal Year: 2013
    ..Overall, we hope to elucidate the fundamental molecular changes that occur in myotonic dystrophy and identify novel targets for future therapeutics. ..
  61. Cellular regulation of Sodium-activated Ion Channels
    Leonard K Kaczmarek; Fiscal Year: 2013
    ....
  62. Tis11 mediated mRNA degradation regulates intestinal stem cell quiescence
    Lindy A McClelland; Fiscal Year: 2012
    ..I have identified the RNA binding protein Tis11 as an inhibitor of stem cell proliferation that is specifically expressed in stem cells...
  63. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..Increased knowledge of the mechanism by which IRP2 regulates iron balance and cell proliferation is important for developing therapeutics that can be used to target cancer cells and treat iron disorders. ..
  64. Delineation of the molecular mechanisms underlying group A Streptococcus virulenc
    Paul Sumby; Fiscal Year: 2013
    ..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..
  65. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    Clinton C MacDonald; Fiscal Year: 2013
    ..Using a variety of techniques, we want to learn the molecular causes of why sperm production fails in males missing the CSTF2T gene, to better understand how to assist these infertile couples. ..
  66. Characterizing gene regulation with single molecule sensitive probes
    Philip J Santangelo; Fiscal Year: 2013
    ..activity of cancer cells by assessing mRNAs already transcribed, and 2) by characterizing mRNA/RNA binding protein interactions in the cellular/tissue milieu...
  67. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
  68. Role of FUS in ALS
    Haining Zhu; Fiscal Year: 2013
    ..The findings are expected to provide critical insights into the mechanisms by which FUS mutations perturb the RNA processing pathways and ultimately lead to the disease. ..
  69. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
    ....
  70. MOLECULAR PATHOGENESIS OF MYOTONIC DYSTROPHY
    THOMAS ALEXANDER COOPER; Fiscal Year: 2013
    ..expanded repeat RNA activates protein kinase C (PKC) and induces PKC-dependent phosphorylation of a second RNA binding protein, CUG-binding protein 1 (CUGBP1), resulting in its stabilization and up-regulation...
  71. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..We hypothesize that formation of SGs is initiated through heat-induced aggregation of the RNA binding protein TIA-1, and that SGs in turn activate JNKs through a tumor necrosis factor (TNF) receptor-associated factor ..
  72. The Functional Role of RBM45 in Gene Expression and Neurodegeneration
    Mahlon Collins; Fiscal Year: 2013
    ..performed a cerebrospinal fluid (CSF)-based proteomics study of ALS patients and identified the novel RNA binding protein RBM45 as a putative disease biomarker...
  73. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    ..mutans. Aim 2. Investigate the role of small RNAs, a ribonuclease, and an RNA binding protein encoded within the yidC gene clusters in the regulation of yidC expression and function of the YidC ..
  74. Role of MEF2 and neural activity in cortical synaptic weakening and elimination
    Kimberly M Huber; Fiscal Year: 2013
    ..We find that the RNA binding protein, Fragile X Mental Retardation Protein (FMRP) is required for MEF2- triggered synapse elimination by ..
  75. A new tool for the cell-specific identification of RNA binding protein targets
    Michael Rosbash; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A new tool for the cell-specific identification of RNA binding protein targets. This proposal has its origins in my interest in post-transcriptional regulation in the Drosophila circadian system...
  76. TRANSLATIONAL CONTROL OF CYTOMEGALOVIRUS GENE EXPRESSION
    Adam P Geballe; Fiscal Year: 2013
    ..In addition to aiding the development of the animal models, these studies will provide insights into the fundamental roles and evolution of dsRNA-binding proteins found in many viral systems. ..
  77. Targeting a Toxic RNA with Small Molecules
    JOHN ANDREW BERGLUND; Fiscal Year: 2013
    ..gain-of-function mechanism;the expanded CUG and CCUG repeat RNAs act as toxic RNAs to sequester MBNL1, a RNA binding protein, and also indirectly increase the protein levels of CUGBP1, another RNA binding protein, which disrupts the ..
  78. Asymmetric cell division of CNS progenitor cells
    Sally Temple; Fiscal Year: 2013
    ..In Drosophila, Staufen is a double-stranded RNA binding protein that carries the mRNA of determinants such as Prospero, and is asymmetrically segregated from the stem-like ..
  79. A Role for the Novel Poly(A) RNA-Binding Protein, ZC3H14, in Breast Cancer
    CALLIE PREAST WIGINGTON; Fiscal Year: 2013
    ..This study will provide insight into the role of poly (A) RBPs such as ZC3H14 as post-transcriptional regulatory players and their potential involvement in breast cancer. ..
  80. Post-transcriptional regulation of gene expression in major TDP43 diseases
    NEIL MACDONALD RENWICK; Fiscal Year: 2013
    ..This research is relevant to NIH's mission to pursue fundamental knowledge and goal to foster innovative research strategies and their applications to advance the Nation's capacity to protect and improve health. ..
  81. Deregulation of MSI RNA-binding proteins promotes intestinal tumorigenesis
    CHRISTOPHER JOACHIM LENGNER; Fiscal Year: 2013
    ..In neuroblasts of Drosophila melanogaster this process is governed by the activity of the Musashi RNA binding protein, whose mammalian orthologs, Msi1 and Msi2, are highly expressed in mammalian intestinal stem cells and in ..
  82. A New Paradigm for Cell Size Control by the RB Tumor Suppressor Pathway
    James Umen; Fiscal Year: 2013
    ..RB) tumor suppressor pathway, a cyclin dependent kinase, CDKG1, that phosphorylates RB, and an RNA binding protein, TNY1...
  83. Mechanism of mRNA Processing/Transport
    Anita H Corbett; Fiscal Year: 2013
    ..gene, which encodes a ubiquitously expressed, evolutionarily conserved, zinc finger, nuclear polyadenosine RNA binding protein (Pab), that cause an autosomal recessive form of non- syndromic intellectual disability (previously termed ..
  84. Picornavirus Genome Replication
    Craig E Cameron; Fiscal Year: 2013
    ....
  85. MBNL1's function in myofibroblast transformation and fibrosis
    Jennifer Davis; Fiscal Year: 2013
    ....
  86. POSTTRANSCRIPTIONAL REGULATION OF ANTIOXIDANT ENZYMES
    LINDA CLERCH; Fiscal Year: 2002
    ....
  87. Rational targeting of protein translation of cancer treatments
    DAVID JOSEPH WEBER; Fiscal Year: 2013
    ..Our preliminary data indicate that the stress-activated RNA binding protein hnRNP A18 confers growth advantage to cancer cells by regulating the expression of key proteins that ..
  88. Comprehensive identification of post transcriptional regulators of gld-1 mRNA
    JOHN BRENNER; Fiscal Year: 2013
    ..of gld-1 are known: FBF-1 and FBF-2 are RNA-binding proteins that directly repress gld-1, whereas the RNA binding protein GLD-3, the poly-A polymerases GLD-2 and GLD-4, and NOS-3 activate gld-1...
  89. Molecular characterization of a novel function of the RNA-binding protein Rbfox
    ARNALDO CARREIRA; Fiscal Year: 2013
    ..We anticipate that these efforts will improve our knowledge of the human RBFOX1 function and possibly its role in human pathogenesis. ..
  90. Analysis of the RNA-binding Protein FUS and Its Role in Neurodegenerative Disease
    Jacob C Schwartz; Fiscal Year: 2013
    ..abstract_text> ..
  91. Investigation of nuclear transport dysfunction in an ocular model of FTLD
    Michael Emmerson Ward; Fiscal Year: 2013
    ..TDP-43 is a DNA/RNA binding protein that is normally concentrated in the nucleus...
  92. STRUCTURES OF RNA BINDING PROTEINS FROM INFLUENZA VIRUS
    Gaetano Montelione; Fiscal Year: 2000
    ..These analogs will have great significance both in fundamental studies as well as in treating (or in developing drugs for) obesity, hypertension and failing heart. ..
  93. FMRP-regulated association of specific miRNAs with RISC
    BART RUSSELL ANDERSON; Fiscal Year: 2013
    ....
  94. Screen for Inhibitors of La-dependent IRES-mediated Translation in Cancer Cells
    Tilman Heise; Fiscal Year: 2013
    ..Ultimately, such knowledge might be translated into new therapeutic strategies targeting the expression of tumor-promoting factors in cancer. ..
  95. Mechanism of cell size checkpoint control by a Musahi-like RNA binding protein
    Bradley J S C Olson; Fiscal Year: 2010
    ..This proposal focuses on an RNA binding protein, TNY1, which regulates the size checkpoint pathway through MAT3/RB...
  96. BRUCELLA STATIONARY PHASE GENE EXPRESSION AND VIRULENCE
    ROY M ROOP; Fiscal Year: 2010
    Hfq is an RNA binding protein that plays multiple roles in the post-transcriptional regulation of gene expression in bacteria...
  97. Functional studies of the Fragile X Mental Retardation Protein: switching from re
    Mihaela Mihailescu; Fiscal Year: 2009
    ..FMRP is an RNA binding protein believed to be involved in the transport and translation regulation of specific messenger RNA (mRNA) ..
  98. THYROID/RETINOIC ACID RECEPTOR INTERACTING PROTEINS
    Mukul Mathur; Fiscal Year: 2004
    ..The 65 kDa protein is a RNA binding protein TLS, that was originally identified as part of a fusion protein associated with human myxoid liposarcoma...
  99. Role of an RNA-Binding Protein in Mammary Carcinogenesis
    Jeffrey Ross; Fiscal Year: 2009
    ..By investigating the oncogenic properties of the CRD-BP, the RNAs it affects in vivo, and its interactions with tumor-inducing genetic and environmental factors, we hope to uncover novel tumorigenesis pathways. ..
  100. ELAV-LIKE PROTEINS IN NEUROBLASTOMA
    Susan Cohn; Fiscal Year: 2000
    ..Thus, ultimately, these studies may provide the clues necessary for the development of effective therapy for children with NB tumors that express high levels of N-myc and are clinically aggressive. ..
  101. Role of the guide RNA binding protein RBP16 in the bloodstream form of T. brucei
    John C Fisk; Fiscal Year: 2010
    ..Thus, proteins involved in RNA editing are promising targets for chemotherapeutic attack. The RNA binding protein, RBP16, is an essential multi-functional gene regulatory protein that acts as an RNA editing accessory ..