Genomes and Genes
Gene Symbol: RBMS3
Description: RNA binding motif single stranded interacting protein 3
Alias: RNA-binding motif, single-stranded-interacting protein 3, RNA binding motif, single stranded interacting protein, RNA-binding protein
Publications781 found, 100 shown here
- Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteinsD Penkov
Brookdale Center in the Department of Biochemistry, Mount Sinai School of Medicine, New York, NY, USA
Gene 243:27-36. 2000..element of the alpha2(I) collagen promoter (Box 5A) has led to the identification of a novel gene product (RBMS3)...
- RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1Dillon Fritz
Department of Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL 32306 4300, USA
J Mol Biol 371:585-95. 2007..Here, we show that expression of the RNA-binding protein RBMS3 is upregulated in the activation of HSCs and fibrotic livers...
- Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinomaYan Li
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Res 71:6106-15. 2011..In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24...
- Reconstitution of human telomerase activity in vitroT L Beattie
Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
Curr Biol 8:177-80. 1998..Substitution of conserved amino acid residues in the reverse transcriptase domain of TP2 completely abolished telomerase activity. We suggest that TP2 and hTR might represent the minimal catalytic core of human telomerase...
- The essential yeast RNA binding protein Np13p is methylatedC W Siebel
Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
Proc Natl Acad Sci U S A 93:13641-6. 1996..Using a monoclonal antibody, 1E4, we have shown that the yeast NPL3 gene product Np13p, an essential RNA binding protein with repeated RGG motifs, is arginine-methylated in vivo...
- A yeast RNA-binding protein shuttles between the nucleus and the cytoplasmJ Flach
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
Mol Cell Biol 14:8399-407. 1994..This toxicity depends on the presence of series of unique repeats in the N terminus and localization to the nucleus. We suggest that the properties of Npl3 are consistent with it being involved in export of RNAs from the nucleus...
- Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcriptionF D Schubot
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
Protein Sci 10:1980-8. 2001..Based on the structure, we propose that the promoter specificity region is located on the mitochondrial RNA polymerase and that binding of sc-mtTFB indirectly mediates interaction of the core enzyme with the promoter site...
- The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targetingE M Ellis
Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
Gene 132:175-83. 1993..We have cloned and sequenced the wild-type allele of one of these genes (MTS1) and shown that it encodes a member of a family of RNA-binding proteins that is essential for growth...
- Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cellsA Mas
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain
Horm Metab Res 30:118-22. 1998..These domains could be targets for a RNA-binding protein induced by treatment with epinephrine producing a destabilization of IR mRNA in U-937 cells...
- The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytesMaria Paola Paronetto
Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
Mol Biol Cell 17:14-24. 2006..We also demonstrate that Sam68 shuttles between the nucleus and the cytoplasm in secondary spermatocytes, suggesting that it may promote translation of specific RNA targets during the meiotic divisions...
- Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S and suppresses its translation in vitroJuxiang Yang
Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Biol Reprod 68:853-9. 2003..These data suggest that TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis. Moreover, the Gapds mRNA is the first mRNA shown to have a functional TB-RBP binding site in its 5' UTR...
- The evolution of core proteins involved in microRNA biogenesisDennis Murphy
Bioinformatics, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, Collegeville, Pennsylvania 19426, USA
BMC Evol Biol 8:92. 2008....
- Molecular characterization of a TIA-1-like RNA-binding protein in cells derived from the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)Sayaka Muto
Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo, Kyoto, Japan
Biosci Biotechnol Biochem 73:648-56. 2009....
- The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of phage Q beta RNAP A Kaminski
Unité de Physiologie Cellulaire, Institut Pasteur, Paris, France
Proc Natl Acad Sci U S A 91:4663-7. 1994..A null mutant, constructed by disruption of nrfA, exhibited the same phenotype as the missense mutant. Thus, an additional factor can be added to the already complex system of nifA regulation in A. caulinodans...
- Posttranscriptional repression of GacS/GacA-controlled genes by the RNA-binding protein RsmE acting together with RsmA in the biocontrol strain Pseudomonas fluorescens CHA0Cornelia Reimmann
Département de Microbiologie Fondamentale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne Dorigny, Switzerland
J Bacteriol 187:276-85. 2005..The transcription and stability of both regulatory RNAs were strongly reduced in the rsmA rsmE double mutant. In conclusion, RsmA and RsmE together account for maximal repression in the GacS/GacA cascade of strain CHA0...
- RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivoJavier G De Gaudenzi
Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, CONICET UNSAM, 1650 San Martin, Provincia de Buenos Aires, Argentina
J Biol Chem 278:18884-94. 2003..Altogether, these results suggest that TcRBPs might be modulated in vivo, to favor or preclude the interaction with specific transcripts in a developmentally regulated manner...
- Xlrbpa, a double-stranded RNA-binding protein associated with ribosomes and heterogeneous nuclear RNPsC R Eckmann
Department of Cytology and Genetics, Institute of Botany, University of Vienna, A 1030 Vienna, Austria
J Cell Biol 138:239-53. 1997..data and the overall organization of the protein suggest that Xlrbpa is the Xenopus homologue of human TAR-RNA binding protein (TRBP), a protein isolated by its ability to bind to human immunodeficiency virus (HIV) TAR-RNA...
- Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1Tongtong Zou
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 409:389-98. 2008....
- Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1Y W Park
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 96:6694-9. 1999....
- Rrp5p, a trans-acting factor in yeast ribosome biogenesis, is an RNA-binding protein with a pronounced preference for U-rich sequencesPaulo de Boer
Section of Biochemistry and Molecular Biology, FEW, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
RNA 12:263-71. 2006..cerevisiae spacer. The implications for the role of Rrp5p in yeast ribosome biogenesis are discussed...
- RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinomaYung Ming Jeng
Graduate Institute of Pathology, National Taiwan University Hospital, Taipei, Taiwan
Hepatology 48:1118-27. 2008..Microarray analysis revealed that IMP3 depletion was associated with downregulation of multiple genes involved in tumor invasion...
- The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitroJinwoo Ahn
Department of Structural Biology, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Retrovirology 7:40. 2010Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) and influences the efficiency of viral reverse transcription (Lemay et al...
- Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-celCanan Doğanlı
Department of Medical Biochemistry, Aarhus University, Aarhus C, Denmark
DNA Cell Biol 29:713-27. 2010..Despite the lack of a conserved nuclear localization signal, the C. elegans ZFR-GFP fusion protein also displayed an intranuclear localization in the 2-cell mouse embryo...
- Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrBT Romeo
Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
Mol Microbiol 29:1321-30. 1998..The presence of csrA homologues in phylogenetically diverse species further suggests that this novel kind of regulatory system is likely to play a broad role in modulating eubacterial gene expression...
- rsmC of the soft-rotting bacterium Erwinia carotovora subsp. carotovora negatively controls extracellular enzyme and harpin(Ecc) production and virulence by modulating levels of regulatory RNA (rsmB) and RNA-binding protein (RsmA)Y Cui
Plant Sciences Unit, University of Missouri, Columbia, Missouri 65211, USA
J Bacteriol 181:6042-52. 1999..betavasculorum, and E. carotovora subsp. carotovora. These findings collectively support the idea that rsmA and rsmB expression in these plant pathogenic Erwinia species is controlled by RsmC or a functional homolog of RsmC...
- Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neuronsNaila Ben Fredj
Neurodégénérescence et Plasticité, INSERM EMI 01 08, Institut National de la Sante et de la Recherche Medicale, Pavillon de Neurologie, Centre Hospitalier Universitaire, 38043 Grenoble, France
J Cell Sci 117:1079-90. 2004..These results support the possible involvement of Sam68 in the activity-dependent regulation of dendritic mRNAs...
- ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding proteinYaya Cui
Department of Plant Microbiology and Pathology, University of Missouri, Columbia, 65211, USA
J Bacteriol 187:4792-803. 2005..carotovora have shown that AHL deficiency causes the production of high levels of RsmA, an RNA binding protein that functions as a global negative regulator of extracellular enzymes and proteins and secondary ..
- The Arabidopsis thaliana double-stranded RNA binding protein DRB1 directs guide strand selection from microRNA duplexesAndrew L Eamens
Commonwealth Scientific and Industrial Research Organisation Plant Industry, Canberra, Australian Capital Territory 2601, Australia
RNA 15:2219-35. 2009In Arabidopsis thaliana (Arabidopsis), DICER-LIKE1 (DCL1) functions together with the double-stranded RNA binding protein (dsRBP), DRB1, to process microRNAs (miRNAs) from their precursor transcripts prior to their transfer to the RNA-..
- Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosisPeng Yuan Wang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 426:293-306. 2010..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs...
- Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cellsMark E Gill
Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 108:7443-8. 2011..In C57BL/6 mice, Dazl is required for licensing. Licensing serves as a gateway from the embryonic processes shared between the sexes--germ cell specification and migration--to the sex-specific pathways of oogenesis and spermatogenesis...
- Bovine coronavirus nonstructural protein 1 (p28) is an RNA binding protein that binds terminal genomic cis-replication elementsKortney M Gustin
Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996 0845, USA
J Virol 83:6087-97. 2009..These results together indicate that nsp1 is an RNA-binding protein that may function to regulate viral genome translation or replication but not by binding SLV-VI within its own coding region...
- RNA-binding protein TIAR is essential for primordial germ cell developmentA R Beck
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:2331-6. 1998..TIAR-deficient mice thus provide a model system to study molecular mechanisms of PGC development and possibly the basis for some forms of idiopathic infertility...
- Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral productionHelen S Christensen
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
J Virol 81:5121-31. 2007..silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components...
- Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiologyNaoshi Kondo
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
Ophthalmology 116:1502-9. 2009....
- Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeastNaoko Mauchi
Department of Molecular Cell Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai, Tsukuba, Japan
Cell Struct Funct 35:95-105. 2010..Our results suggest that MTL1 mRNA bears a cis-acting element involved in destabilization by the decapping enzyme and the 5'-3' exonuclease, and Khd1p stabilizes MTL1 mRNA through binding to this element...
- HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cellsQintong Li
Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
Nucleic Acids Res 35:2503-12. 2007..Our study illuminates novel properties of HEXIM1 both in vitro and in vivo, and suggests that HEXIM1 may be involved in other nuclear and cytoplasmic processes besides controlling P-TEFb...
- Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modificationY P Liu
Department of Chemistry, Rutgers State University of New Jersey 08855 0939, USA
Biol Signals 6:166-74. 1997..Our study also suggests the possibility of using a gel mobility shift assay for eIF-5A-RNA binding as a functional assay for deoxyhypusine and hypusine formation...
- DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLCH A Drabkin
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
Oncogene 18:2589-97. 1999DEF-3(g16/NY-LU-12) encodes a novel RNA binding protein isolated by positional cloning from an SCLC homozygous deletion region in 3p21.3 and, in parallel, as a differentially expressed gene during myelopoiesis from FDCPmix-A4 cells...
- The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neuronsLaetitia Davidovic
Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
Hum Mol Genet 15:1525-38. 2006..We propose that this novel cellular partner for FMRP escorts FMRP-containing mRNP from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation...
- Ethanol inhibited apoptosis-related RNA binding protein, Napor-3 gene expression in the prenatal rat brainNibedita Naha
Division of Life Science, Applied Life Science BK 21, College of Natural Science, Gyeongsang National University, Jinju, South Korea
Med Sci Monit 15:BR6-12. 2009..The objective of the present study was to observe whether maternal ethanol exposure can alter gene expression pattern in mother and in fetus during mid and late prenatal stage...
- RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 casesDengfeng Cao
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Mod Pathol 24:288-96. 2011..03) and was therefore more sensitive. For primary extragonadal yolk sac tumors, combining LIN28 and SALL4 can achieve a higher diagnostic sensitivity than either alone...
- Part of Xenopus translin is localized in the centrosomes during mitosisA Castro
Centre de Recherches de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, Montpellier Cedex 5, 34293, France
Biochem Biophys Res Commun 276:515-23. 2000..Interestingly, part of X-translin underwent a remarkable redistribution throughout mitosis and associated with centrosomes, which may suggest a new unknown role for this protein in cell cycle...
- A family of cold-regulated RNA-binding protein genes in the cyanobacterium Anabaena variabilis M3N Sato
Laboratory of Life Science, Tokyo Gakugei University, Japan
Nucleic Acids Res 23:2161-7. 1995..Gel-filtration assay showed that all of the Rbp proteins have higher affinities to poly(G) and poly(U) than to poly(A) and poly(C)...
- Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cellsLan Xiao
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 18:4579-90. 2007..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
- Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptorsKanako Susaki
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Exp Eye Res 88:347-55. 2009..Studying the regulation of Msi1 and the target RNAs of Msi1 in photoreceptors and RPE cells might contribute to fundamental and clinical studies of retinal degeneration...
- Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cellsChristine Hostetter
Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
Cancer Biol Ther 7:1496-506. 2008..We found that inhibition of JNK, a member of the MAPK family, decreases cytoplasmic accumulation of the RNA binding protein HuR...
- Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newtJun Kaneko
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
Neurosci Lett 450:252-7. 2009..All together, it is probable that Msi1 is one of the essential factors that need to be regulated in retinal regeneration...
- Predicting RNA-binding residues from evolutionary information and sequence conservationYu Feng Huang
Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
BMC Genomics 11:S2. 2010..The ability to computationally predict RNA-binding residues in a RNA-binding protein can help biologists reveal important site-directed mutagenesis in wet-lab experiments...
- Identification of calreticulin as a rubella virus RNA binding proteinN K Singh
Laboratory of Molecular Pharmacology, Food and Drug Administration, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:12770-4. 1994..In the present study, we have purified the RNA binding protein and identified it as a simian homologue of human calreticulin...
- Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolutionC Davies
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Structure 4:1093-104. 1996..S8 also controls the synthesis of several ribosomal proteins by binding to mRNA. It binds specifically to very similar sites in the two RNA molecules...
- Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system developmentG H Clayton
Neurology and Pediatrics, Dept of Neurology, B 182, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
Brain Res Dev Brain Res 109:271-80. 1998..The marked restriction of HuD mRNA expression with maturity suggests that its functional role in adult neurons varies significantly throughout the CNS...
- BglG, the transcriptional antiterminator of the bgl system, interacts with the beta' subunit of the Escherichia coli RNA polymeraseA Nussbaum-Shochat
Department of Molecular Biology, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 96:4336-41. 1999..The beta' subunit, produced in excess, prevented BglG activity as a transcriptional antiterminator. Possible roles of the interaction between BglG and the polymerase beta' subunit are discussed...
- N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapsesYi Shuian Huang
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 21:2139-48. 2002..These data demonstrate a remarkable conservation of the regulatory machinery that controls signal-induced mRNA translation, and elucidates an axis connecting the NMDA receptor to localized protein synthesis at synapses...
- Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repressionRachid Mazroui
Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, 10 rue de l Espinay, Quebec G1L 3L5, PQ, Canada
Hum Mol Genet 11:3007-17. 2002..We speculate that, in neurons, FMRP plays a role as a mRNA repressor in incompetent mRNP granules that have to be translocated from the cell body to distal locations such as dendritic spines and synaptosomes...
- NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomesBarbara Bardoni
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch, C U de Strasbourg, France
Exp Cell Res 289:95-107. 2003..FMRP is an RNA binding protein reported to be involved in translational control, notably at postsynaptic sites of protein synthesis as a ..
- Ablation of the Sam68 RNA binding protein protects mice from age-related bone lossStephane Richard
Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
PLoS Genet 1:e74. 2005The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism; however, its physiologic role has remained elusive...
- No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureusChantal Bohn
Signalisation et Réseaux de Régulations Bactériens, Institut de Genetique et Microbiologie, CNRS UMR 8621, Centre Scientifique d Orsay, Universite Paris Sud, Orsay Cedex, France
BMC Microbiol 7:10. 2007..In this study, we investigate the function of Hfq in the Gram-positive pathogen Staphylococcus aureus, by constructing hfq null mutant derivatives...
- AsSIRTing the DNA damage responseMyriam Gorospe
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Trends Cell Biol 18:77-83. 2008..This article covers the regulatory pathway of HuR-->SIRT1-->NBS1, through which post-transcriptional and post-translational effectors contribute to the maintenance of genomic integrity...
- Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRPSimon P Reeve
Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, Flanders Institute for Biotechnology, 3000 Leuven, Belgium
J Neurosci 28:3221-6. 2008..Thus, our mutational analyses establish that the N terminus of FMRP is critical for its neuronal function...
- Localization of the Carnation Italian ringspot virus replication protein p36 to the mitochondrial outer membrane is mediated by an internal targeting signal and the TOM complexYeen Ting Hwang
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
BMC Cell Biol 9:54. 2008....
- Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virionsSarah L Noton
Department of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom
J Virol 83:562-71. 2009..Thus, we have identified a late-acting defect in NP that, separate from its function in RNA synthesis, indicates a role for the polypeptide in virion assembly, most likely involving M1 as a partner...
- Visualizing protein-RNA interactions inside cells by fluorescence resonance energy transferMike Lorenz
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
RNA 15:97-103. 2009..Interestingly, PTB and Raver1 were bound to RNAs all over the nucleus, as expected, but additionally interacted with RNAs in the perinucleolar compartment (PNC), where only noncoding Pol III transcripts are present...
- LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophagesTina Ruggiero
RNA Technology Laboratory, Centro Biotecnologie Avanzate, Genoa, Italy
FASEB J 23:2898-908. 2009..Our studies unveil the existence of an LPS-dependent post-transcriptional regulation of miR-155 biogenesis. Once induced, miR-155 finely tunes the expression of select inflammation mediators in response to LPS...
- Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densitiesJanin Schütt
Institute for Human Genetics, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
J Biol Chem 284:25479-87. 2009..As Shank1 controls dendritic spine morphology, our data suggest that dysregulation of Shank1 synthesis may significantly contribute to the abnormal spine development and function observed in brains of fragile X syndrome patients...
- Identification of cellular factors binding to acetylated HIV-1 integraseAwatef Allouch
Molecular Biology Laboratory, Scuola Normale Superiore, Pisa, Italy
Amino Acids 41:1137-45. 2011..Nevertheless, few two-hybrid hits bind with the same affinity the acetylated and the unmodified IN. These results further underlie the relevance of IN post-translational modification by acetylation in HIV-1 replication cycle...
- Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1Gudrun Ziegeler
Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 285:15408-19. 2010..This is the first demonstration that HuR-dependent mRNA stability and HuR-independent mRNA translation plays a critical role in the regulation of post-transcriptional p27(Kip1) expression...
- Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferiMeghan C Lybecker
Division of Biological Sciences, The University of Montana, Missoula, MT 59812 4824, USA
Mol Microbiol 78:622-35. 2010..These data suggest that Hfq plays a key role in the regulation of pathogenicity factors in B. burgdorferi and we hypothesize that the spirochete has a complex Hfq-dependent sRNA network...
- A novel mRNA affinity purification technique for the identification of interacting proteins and transcripts in ribonucleoprotein complexesBoris Slobodin
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
RNA 16:2277-90. 2010..Finally, RaPID could also be used to show biochemically the coexistence of different RNA species within the same RNP complex (e.g., coprecipitation of the yeast SRO7, WSC2, SEC3, and IST2 mRNAs with ASH1 mRNA) for the first time...
- AFQ056, a new mGluR5 antagonist for treatment of fragile X syndromeJosien Levenga
Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Neurobiol Dis 42:311-7. 2011..These results suggest that AFQ056 might be a potent mGluR5 antagonist to rescue various aspects of the fragile X phenotype...
- MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1Hong Yu
Department of Craniofacial Biology and the Center for Oral Health Research, Medical University of South Carolina, SC 29425, United States
Cytokine 56:245-55. 2011..Thus, this work provides new mechanistic insight of MKP-1 signaling and regulation of cytokine mRNA stability through RNA binding proteins in response to inflammatory stimuli...
- FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismJennifer C Darnell
Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
Cell 146:247-61. 2011..In addition, they provide insight into the molecular basis of the cognitive and allied defects in FXS and ASD and suggest multiple targets for clinical intervention...
- Genome-wide screening for genes associated with FK506 sensitivity in fission yeastYan Ma
Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
PLoS ONE 6:e23422. 2011..8 genes), chromatin remodeling (6 genes), cytokinesis (4 genes), ribosomal protein (3 genes), RNA binding protein (3 genes), and a variety of other known functions (17 genes) or still unknown functions (5 genes) in the ..
- Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cellsE Roggli
Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, CH 1005 Lausanne, Switzerland
Diabetologia 55:1699-708. 2012..We investigated the involvement of AUF1 in cytokine-induced beta cell dysfunction...
- Mex3c mutation reduces adiposity and increases energy expenditureYan Jiao
Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Mol Cell Biol 32:4350-62. 2012..Our data show that Mex3c is involved in energy balance regulation...
- The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neuronsKrishna H Zivraj
Institute for Human Genetics, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Neurochem 124:670-84. 2013..Thus, in neurons MARTA2 appears to represent a key trans-acting factor involved in KIF5-mediated dendritic targeting of MAP2 mRNAs...
- Picornavirus modification of a host mRNA decay proteinJanet M Rozovics
Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, USA
MBio 3:e00431-12. 2012..Here we describe experiments suggesting that AUF1, a host RNA binding protein involved in mRNA decay, plays a role in the infectious cycle of picornaviruses such as poliovirus and human ..
- RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendritesMatthew E Klein
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 110:3125-30. 2013..Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb and may provide insight into the pathophysiology of fragile X tremor/ataxia syndrome...
- Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dyneinYang Liu
Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
Genes Dev 27:1233-46. 2013..Overall, our data reveal a pivotal role of a highly asymmetric coiled-coil domain in coordinating the assembly of cargo-motor complexes...
- Splicing factor TRA2B is required for neural progenitor survivalJacqueline M Roberts
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California, 95064
J Comp Neurol 522:372-92. 2014Alternative splicing of pre-mRNAs can rapidly regulate the expression of large groups of proteins. The RNA binding protein TRA2B (SFRS10) plays well-established roles in developmentally regulated alternative splicing during Drosophila ..
- Rbfox2 controls autoregulation in RNA-binding protein networksMohini Jangi
David H Koch Institute for Integrative Cancer Research
Genes Dev 28:637-51. 2014..Our findings uncover an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned. ..
- Human somatic cell mutagenesis creates genetically tractable sarcomasSam D Molyneux
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Nat Genet 46:964-72. 2014..Hybrid viral-transposon systems may accelerate the functional annotation of cancer genomes by enabling insertional mutagenesis screens in higher eukaryotes that are not amenable to germline transgenesis. ..
- Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damageGayathri Gurunathan
Terry Fox Molecular Oncology Group and Segal Cancer Center, Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, Quebec, Canada H3T 1E2
Sci Rep 5:10475. 2015..Herein we identify the DNA damage protein and RNA binding protein, hnRNPUL1, to be a substrate of PRMT1...
- RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant DefenseCong Ren
From the Comparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616
J Biol Chem 291:9629-37. 2016..Together, our data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence. ..
- Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40Robert Janowski
Group Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, Neuherberg DE 85764, Germany
Nat Commun 7:11032. 2016..In cells, ADE-like and CDE-like motifs cooperate in the repression of Ox40 by Roquin. Our data reveal an unexpected recognition of hexaloop cis elements for the posttranscriptional regulation of target messenger RNAs by Roquin. ..
- The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translationRosario Francisco-Velilla
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Nicolas Cabrera 1, 28049 Madrid, Spain
Nucleic Acids Res 44:8335-51. 2016..Our study uncovers a crosstalk between this protein and the ribosome, and provides support for the view that Gemin5 may control translation elongation. ..
- An Intronic Polymorphism in couch potato Is Not Distributed Clinally in European Drosophila melanogaster Populations nor Does It Affect Diapause InducibilityValeria Zonato
Department of Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom
PLoS ONE 11:e0162370. 2016couch potato (cpo) encodes an RNA binding protein that has been reported to be expressed in the peripheral and central nervous system of embryos, larvae and adults, including the major endocrine organ, the ring gland...
- Cleavage of influenza RNA by using a human PUF-based artificial RNA-binding protein-staphylococcal nuclease hybridTomoaki Mori
Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Tsushima Naka, Kita ku, Okayama 700 8530, Japan
Biochem Biophys Res Commun 479:736-740. 2016..Improvement of the binding properties or the design method will allow the SNase-fusion nuclease to cleave an RNA target in mammalian animal cells and/or organisms...
- Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene ExpressionDeepshikha Kumar
School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
PLoS ONE 11:e0164146. 2016..Altered expression of late viral genes and titers following manipulation of host cellular nucleolin, proposes the functional importance of its interaction with nucleoprotein during influenza A virus infection...
- A small bacterial RNA regulates a putative ABC transporterMaria Antal
Biochimie Pharmaceutique, Universite de Rennes I, UPRES Jeune Equipe 2311, ESPRI INSERM, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
J Biol Chem 280:7901-8. 2005..We conclude that RydC regulates the yejABEF-encoded ABC permease at the mRNA level. This small RNA may contribute to optimal adaptation of some Enterobacteria to environmental conditions...
- Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunitCarl R Urbinati
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Mol Genet Genomics 276:369-77. 2006....
- The Pseudomonas putida Crc global regulator is an RNA binding protein that inhibits translation of the AlkS transcriptional regulatorRenata Moreno
Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia, CSIC, Campus de la Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Mol Microbiol 64:665-75. 2007..Because AlkS is an unstable protein present in limiting amounts, reducing its levels leads to decreased expression of all genes in the pathway...
- Molecular characterization and expression analysis of a glycine-rich RNA-binding protein gene from Malus hupehensis RehdShuncai Wang
State Key Laboratory of Crop Stress Biology in Arid Areas, College of Horticulture, Northwest A and F University, Yangling, 712100, Shaanxi, People s Republic of China
Mol Biol Rep 39:4145-53. 2012..These results suggest that MhGR-RBP1 may be involved in the responses to abiotic stresses, H(2)O(2), ABA, or JA...
- Insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinomaChiao Ying Lin
Department of Dentistry, School of Dentistry, National Taiwan University Hospital, Taipei, Taiwan
J Oral Pathol Med 40:699-705. 2011..This study aimed to investigate the clinical significance and functional role of IGF2BP3 expression in oral squamous cell carcinoma (OSCC)...
- Every which way--nanos gene regulation in echinodermsNathalie Oulhen
Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island
Genesis 52:279-86. 2014....
- Chromatin immunoprecipitation approaches to determine co-transcriptional nature of splicingNicole I Bieberstein
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Methods Mol Biol 1126:315-23. 2014..The activities of any RNA binding protein can in principle be monitored using ChIP, and RNA dependency of binding can also be assessed through RNase ..
- Circular RNAs: Identification, biogenesis and functionKaroline K Ebbesen
Department of Molecular Biology and Genetics MBG, Interdisciplinary Nanoscience Center iNANO, Aarhus University, Aarhus, Denmark
Biochim Biophys Acta 1859:163-8. 2016..This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. ..
- Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinomaHedieh Fardmanesh
Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Gene 581:146-51. 2016..In conclusion, our study suggested that upregulation of DGCR8 may be involved in tumorigenesis and aggressiveness of IDC and may serve as future therapeutic target. ..
- HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosisNa Chang
Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No 10 Xitoutiao, You An Men, Beijing, 100069, China
J Mol Med (Berl) 95:69-82. 2017..HuR participates in upregulation of S1PR3 induced by S1P. S1P results in phosphorylation and translocation of HuR via S1PR3. Our results provide a new regulatory manner to the mechanism of liver fibrogenesis...
- A 69-kDa RNA-binding protein from Xenopus oocytes recognizes a common motif in two vegetally localized maternal mRNAsS P Schwartz
Department of Anatomy and Embryology, Hebrew University Medical School, Jerusalem, Israel
Proc Natl Acad Sci U S A 89:11895-9. 1992..These data indicate that vegetally localized mRNAs share a binding motif that helps them achieve their intracellular distribution through specific RNA-protein interactions...
- Cloning and characterization of cold-regulated glycine-rich RNA-binding protein genes from leafy spurge (Euphorbia esula L.) and comparison to heterologous genomic clonesD P Horvath
U S Department of Agriculture, Agricultural Research Service, State University Station, Fargo, ND 58105 5674, USA
Plant Mol Biol 38:531-8. 1998..These transcripts are induced in response to low temperatures in roots, stems and leaves, but are expressed constitutively in tissue culture at control temperatures...
- Evidence for 3' untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAVM L Samson
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
Genetics 150:723-33. 1998..I discuss the implications of these results for normal elav function...
Research Grants115 found, 100 shown here
- Genetic variation and regulatory networks: Mechanisms and complexityDANA PE ER; Fiscal Year: 2009..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
- NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2016..Our research suggests that the RNA binding protein HuD and the microRNA miR-495 play opposite roles in the control of addiction-related gene expression and ..
- Impact of miR-495 vs. HuD in the Control of Addiction-Related Genes and BehaviorNORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013..A better understanding of these regulatory mechanisms is a pre-requisite for the application of these new tools in addiction research and ultimately in the treatment of this disorder. ..
- Fragile X Mental Retardation Protein translation regulator function: interactionsMIHAELA R MIHAILESCU; Fiscal Year: 2013..FMRP is an RNA binding protein involved in the transport and translation regulation of specific messenger RNA (mRNA) targets...
- Dissecting the molecular basis of fragile X syndrome in DrosophilaPeng Jin; Fiscal Year: 2011..abstract_text> ..
- Kaylen Lott; Fiscal Year: 2015..Overall, the proposed experiments will provide insight into the functions of an essential RBP in T. brucei and elucidate how arg methylation can modulate these functions. ..
- Regulation and Function of Germline RNP GranulesJENNIFER SCHISA; Fiscal Year: 2010..This research tests the hypothesis that large RNP granules play a protective role in maintaining oocyte viability and fertility and may be relevant to understanding the basis for infertility that occurs as women age. ..
- Vivian Bellofatto; Fiscal Year: 2014..brucei. This exploratory, two-year project is grounded in preliminary data, in a recent publication from our laboratory, preliminary data and complementary in vivo molecular genetic and in vitro biochemical approaches. ..
- VISWANATHAN PALANISAMY; Fiscal Year: 2016..Thus, our data will provide a foundation for understanding the role of HuR in oral mucositis-associated gene regulation and will be pivotal for future studies into HuR-associated oral diseases. ..
- Xinbin Chen; Fiscal Year: 2016....
- Michael Cleary; Fiscal Year: 2016..This work will generate a comprehensive and predictive network map of neural mRNA decay dynamics, thus filling a significant gap in current models of gene expression during neural development. ..
- RNA Binding Proteins in CancerShrikant Anant; Fiscal Year: 2013The broad goal of the project is to understand the mechanisms by which RNA binding protein RBM3 regulates gene expression at the posttranscriptional level of mRNA stability and translation in cancer cells...
- Kelsey C Martin; Fiscal Year: 2014..For example, mutations in Fragile X Mental Retardation protein, an RNA binding protein involved in RNA trafficking and translational regulation at the synapse, represent the most common single ..
- Encyclopedia of C elegans 3'UTRS and their regulatory elementsFabio Piano; Fiscal Year: 2011..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
- Circadian regulation of microRNA biogenesis and functionPeter W Vanderklish; Fiscal Year: 2012..In light of emerging data that disruptions in circadian rhythm and miRNA expression underlie many disease states, our studies should provide important insights into disease-related processes of the nervous system. ..
- MOLECULAR CLONING OF THE FRAGILE X SITEStephen T Warren; Fiscal Year: 2011..Deep fundamental knowledge of a disease is the best course toward eventual therapeutics. ..
- MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORTBenjamin L Shneider; Fiscal Year: 2012..Aim 2: To test the hypothesis that the RNA binding protein HuR regulates the ontogeny of ASBT via changes in mRNA stability...
- Richard I Gregory; Fiscal Year: 2016..These studies are relevant to the treatment of cancer, diabetes, developmental disorders and numerous degenerative diseases. ..
- A novel therapy for HER2 positive hormone refractory breast cancerAnne W Hamburger; Fiscal Year: 2010..As several independent groups have demonstrated that EBP1 is both a DNA and RNA binding protein, we will examine effects on EBP1 on ErbB2 transcription and post-transcriptional events...
- Joseph Avruch; Fiscal Year: 2016..Among them is an RNA binding protein IMP2, first discovered by its ability to bind to an IGF2 mRNA expressed primarily in fetal life, whose ..
- Valérie A Schumacher; Fiscal Year: 2016..Two major foci will be on the role of the RNA binding protein Staufen 2 in regulating mRNA localization in podocytes and the role of Staufen 2 and Staufen 2-associated ..
- Vandana Gupta; Fiscal Year: 2016..Genetic mapping in osoi fish identified a 20 base pair deletion in a novel DEAD-box RNA helicase, a RNA binding protein, resulting in a frameshift mutation. Dr...
- Tony Romeo; Fiscal Year: 2016..CsrA is an RNA binding protein that regulates mRNA translation and stability...
- MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURYJeffrey R Bender; Fiscal Year: 2012..target AU-rich sequences, and requires LFA-1 engagement-induced nuclear-to-cytoplasmic translocation of the RNA binding protein HuR...
- RNA Binding Protein CUGBP2 in Intestinal EpitheliumShrikant Anant; Fiscal Year: 2010..provided by applicant): The broad goal of this application is to understand the mechanisms by which RNA binding protein CUGBP2 regulates gene expression at the posttranscriptional level of mRNA stability and translation in ..
- Role and Function of RNA-Binding Protein La in Oral Tumor ProgressionGunhild Sommer; Fiscal Year: 2012....
- Post-transcriptional control of inflammatory gene expressionThomas A Hamilton; Fiscal Year: 2013..This proposal is focused upon understanding the mechanisms through which IL-17 (and other stimuli) controls degradation of specific inflammation related messenger RNAs and thereby modulates aspects of inflammatory response. ..
- Posttranscriptional Gene Regulation in AsthmaUlus Atasoy; Fiscal Year: 2010..Our central hypothesis is that the RNA binding protein, HuR, is coordinately regulating IL-4 and IL-13 cytokine genes during allergen driven asthma...
- Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1Blanche Capel; Fiscal Year: 2013..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..
- AMBROSE LIN YAU CHEUNG; Fiscal Year: 2016..Accordingly, MazFsa and "specific RNA binding proteins" represent novel targets for antibiotic development. As TA systems, DEAD-box and other RNA binding proteins are common in prokaryotes, our results may apply to other pathogens. ..
- DAVID IRWIN GREENSTEIN; Fiscal Year: 2014..The small roundworm C. elegans is an established model for studying the hormonal control of meiosis. These studies will define the signaling mechanisms controlling female meiosis and provide insights into the origin of meiotic errors. ..
- Anand Venugopal; Fiscal Year: 2015..RNA binding motif 3 (RBM3) is an RNA binding protein that is expressed in the intestinal epithelial cells...
- REGULATION OF SYNAPSE ELIMINATION BY FMRPJULIA RIVES WILKERSON; Fiscal Year: 2011..The results of these experiments may lead to the development of new therapies for autism and mental retardation disorders. ..
- A structure-function analysis of let-7g miRNA regulation by Lin28CHRISTINA ROSE MOZES; Fiscal Year: 2012....
- Ulus Atasoy; Fiscal Year: 2016..Our hypothesis is that the RNA binding protein, HuR, is coordinately regulating Th2 polarization and cytokine gene expression in allergic airway ..
- Christopher J Rhodes; Fiscal Year: 2014..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
- Keith L Kirkwood; Fiscal Year: 2015..These studies will establish the role of a key RNA binding protein in experimental models and human periodontitis...
- Kimberly Huber; Fiscal Year: 2015..Fmr1 encodes a neuronal RNA binding protein, Fragile X Mental Retardation Protein (FMRP) 6...
- The toxicity of the RNA CGG repeats in FXTASLubov T Timchenko; Fiscal Year: 2013..The identification of the early toxic events which trigger progression of FXTAS will provide a basis for the development of the therapeutic approaches for FXTAS. ..
- RNA-binding Protein HuR in Allergic InflammationCristiana Stellato; Fiscal Year: 2009..abstract_text> ..
- Jennifer C Darnell; Fiscal Year: 2016....
- Maha Abdellatif; Fiscal Year: 2014..2) Examine the mechanisms of function of miR-21 and its target genes, FasL and PTEN, in cardiac myocytes. 3) Study the function of miR-21 and its regulation in vivo. ..
- DANIEL BATTLE; Fiscal Year: 2015..Finally, we will define how Gemin5 controls gene expression in SMA by using neuronal cells with reduced SMN and an SMA mouse model. ..
- Presynaptic Fragile X ProteinsMichael R Akins; Fiscal Year: 2011..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
- RONALD ANTHONY DEPINHO; Fiscal Year: 2016..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
- RONALD ANTHONY DEPINHO; Fiscal Year: 2014..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
- METABOLIC CONTROL OF PROINSULIN BIOSYNTHESIS TRANSLATIONChristopher Rhodes; Fiscal Year: 2009..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
- Abigail Renoux; Fiscal Year: 2014....
- ADAM JOHN HARRINGTON; Fiscal Year: 2015..With synapse elimination defects observed in autism and FXS, we believe that our studies will significantly enhance our understanding of the neurobiology in these complex diseases. ..
- Role of RNA Binding Proteins in BCR/ABL LeukemogenesisDanilo Perrotti; Fiscal Year: 2012..If the proposed studies will determine modulation of RNA binding protein expression and function antagonize disease progression and efficiently induce apoptosis in the leukemia-..
- Xinyu Zhao; Fiscal Year: 2016..learning and present us a unique opportunity for understanding the specific roles and functional impact of RNA binding protein- mediated translational regulation in postnatal/adult neurogenesis and learning disabilities...
- Vladimir S Spiegelman; Fiscal Year: 2016..2. To delineate the mechanism(s) of CRD-BP regulation by hypoxia. 3. To analyze the (patho)physiologic significance of CRD-BP regulation by hypoxia in melanocytes. ..
- Mechanisms of MEF2-dependent synapse eliminationCARLY FENWICK HALE; Fiscal Year: 2013....
- Laurie R Earls; Fiscal Year: 2014..Dgcr8 is a double-stranded RNA binding protein important for microRNA biosynthesis...
- Michael R Akins; Fiscal Year: 2015..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
- Gene-centered protein-RNA interaction mappingALBERTHA JOHANNA WALHOUT; Fiscal Year: 2012..RAPID is based on translation and mimics endogenous RNA binding protein activity...
- Piotr Sliz; Fiscal Year: 2016..Finally, elucidating how Lin28 inhibits microRNA processing will also provide new information on the mechanism of central events in microRNA processing. ..
- The Regulation of UPA and UPAR in Human Carcinoma CellsShuang Huang; Fiscal Year: 2010..Also, gaining further understanding of the novel role of SECp43 in repressing uPA expression may lead to the development of a novel therapeutic approach to suppress tumor growth and metastasis. ..
- Carol J Wilusz; Fiscal Year: 2014..Overall, we hope to elucidate the fundamental molecular changes that occur in myotonic dystrophy and identify novel targets for future therapeutics. ..
- Small RNAs in Stem Cell Differentiation and Neural DevelopmentRobert H Blelloch; Fiscal Year: 2010..This model is based on the conditional deletion of the RNA binding protein DGCR8, which is required for the processing of pri- to pre-microRNAs...
- Lindy A McClelland; Fiscal Year: 2015..I have identified the RNA binding protein Tis11 as an inhibitor of stem cell proliferation that is specifically expressed in stem cells...
- Leonard K Kaczmarek; Fiscal Year: 2015....
- IRON REGULATION OF GENE EXPRESSIONELIZABETH ANN LEIBOLD; Fiscal Year: 2013..Increased knowledge of the mechanism by which IRP2 regulates iron balance and cell proliferation is important for developing therapeutics that can be used to target cancer cells and treat iron disorders. ..
- Paul Sumby; Fiscal Year: 2014..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..
- Clinton C MacDonald; Fiscal Year: 2015..Using a variety of techniques, we want to learn the molecular causes of why sperm production fails in males missing the CSTF2T gene, to better understand how to assist these infertile couples. ..
- Characterizing gene regulation with single molecule sensitive probesPhilip J Santangelo; Fiscal Year: 2013..activity of cancer cells by assessing mRNAs already transcribed, and 2) by characterizing mRNA/RNA binding protein interactions in the cellular/tissue milieu...
- Mechanism of p63-Dependent Tumor SuppressionXinbin Chen; Fiscal Year: 2012..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
- Haining Zhu; Fiscal Year: 2014..The findings are expected to provide critical insights into the mechanisms by which FUS mutations perturb the RNA processing pathways and ultimately lead to the disease. ..
- Using Drosophila as a model to understand TDP-43 function in ALSDavid B Morton; Fiscal Year: 2012....
- Heat Shock-Induced ApoptosisShawn B Bratton; Fiscal Year: 2012..We hypothesize that formation of SGs is initiated through heat-induced aggregation of the RNA binding protein TIA-1, and that SGs in turn activate JNKs through a tumor necrosis factor (TNF) receptor-associated factor ..
- Thomas A Cooper; Fiscal Year: 2016..expanded repeat RNA activates protein kinase C (PKC) and induces PKC-dependent phosphorylation of a second RNA binding protein, CUG-binding protein 1 (CUGBP1), resulting in its stabilization and up-regulation...
- Mahlon Collins; Fiscal Year: 2014..performed a cerebrospinal fluid (CSF)-based proteomics study of ALS patients and identified the novel RNA binding protein RBM45 as a putative disease biomarker...
- SARA MARIE RASER PALMER; Fiscal Year: 2014..mutans. Aim 2. Investigate the role of small RNAs, a ribonuclease, and an RNA binding protein encoded within the yidC gene clusters in the regulation of yidC expression and function of the YidC ..
- Kimberly Huber; Fiscal Year: 2016..We find that the RNA binding protein, Fragile X Mental Retardation Protein (FMRP) is required for MEF2- triggered synapse elimination by ..
- Michael Rosbash; Fiscal Year: 2016DESCRIPTION (provided by applicant): A new tool for the cell-specific identification of RNA binding protein targets. This proposal has its origins in my interest in post-transcriptional regulation in the Drosophila circadian system...
- Adam P Geballe; Fiscal Year: 2016..In addition to aiding the development of the animal models, these studies will provide insights into the fundamental roles and evolution of dsRNA-binding proteins found in many viral systems. ..
- Andrew Berglund; Fiscal Year: 2014..gain-of-function mechanism;the expanded CUG and CCUG repeat RNAs act as toxic RNAs to sequester MBNL1, a RNA binding protein, and also indirectly increase the protein levels of CUGBP1, another RNA binding protein, which disrupts the ..
- Sally Temple; Fiscal Year: 2015..In Drosophila, Staufen is a double-stranded RNA binding protein that carries the mRNA of determinants such as Prospero, and is asymmetrically segregated from the stem-like ..
- CALLIE PREAST WIGINGTON; Fiscal Year: 2014..This study will provide insight into the role of poly (A) RBPs such as ZC3H14 as post-transcriptional regulatory players and their potential involvement in breast cancer. ..
- CHRISTOPHER JOACHIM LENGNER; Fiscal Year: 2016..In neuroblasts of Drosophila melanogaster this process is governed by the activity of the Musashi RNA binding protein, whose mammalian orthologs, Msi1 and Msi2, are highly expressed in mammalian intestinal stem cells and in ..
- Post-transcriptional regulation of gene expression in major TDP43 diseasesNEIL MACDONALD RENWICK; Fiscal Year: 2013..This research is relevant to NIH's mission to pursue fundamental knowledge and goal to foster innovative research strategies and their applications to advance the Nation's capacity to protect and improve health. ..
- James Umen; Fiscal Year: 2014..RB) tumor suppressor pathway, a cyclin dependent kinase, CDKG1, that phosphorylates RB, and an RNA binding protein, TNY1...
- Anita H Corbett; Fiscal Year: 2016..gene, which encodes a ubiquitously expressed, evolutionarily conserved, zinc finger, nuclear polyadenosine RNA binding protein (Pab), that cause an autosomal recessive form of non- syndromic intellectual disability (previously termed ..
- Craig E Cameron; Fiscal Year: 2016....
- Jennifer Davis; Fiscal Year: 2014....
- POSTTRANSCRIPTIONAL REGULATION OF ANTIOXIDANT ENZYMESLINDA CLERCH; Fiscal Year: 2002....
- DAVID JOSEPH WEBER; Fiscal Year: 2016..Our preliminary data indicate that the stress-activated RNA binding protein hnRNP A18 confers growth advantage to cancer cells by regulating the expression of key proteins that ..
- JOHN BRENNER; Fiscal Year: 2015..of gld-1 are known: FBF-1 and FBF-2 are RNA-binding proteins that directly repress gld-1, whereas the RNA binding protein GLD-3, the poly-A polymerases GLD-2 and GLD-4, and NOS-3 activate gld-1...
- ARNALDO CARREIRA; Fiscal Year: 2014..We anticipate that these efforts will improve our knowledge of the human RBFOX1 function and possibly its role in human pathogenesis. ..