RBMS3

Summary

Gene Symbol: RBMS3
Description: RNA binding motif single stranded interacting protein 3
Alias: RNA-binding motif, single-stranded-interacting protein 3, RNA binding motif, single stranded interacting protein, RNA-binding protein
Species: human

Top Publications

  1. ncbi Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins
    D Penkov
    Brookdale Center in the Department of Biochemistry, Mount Sinai School of Medicine, New York, NY, USA
    Gene 243:27-36. 2000
  2. pmc RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1
    Dillon Fritz
    Department of Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL 32306 4300, USA
    J Mol Biol 371:585-95. 2007
  3. doi Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 71:6106-15. 2011
  4. ncbi Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
  5. pmc The essential yeast RNA binding protein Np13p is methylated
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Proc Natl Acad Sci U S A 93:13641-6. 1996
  6. pmc A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm
    J Flach
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 14:8399-407. 1994
  7. pmc Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription
    F D Schubot
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 10:1980-8. 2001
  8. ncbi The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting
    E M Ellis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
    Gene 132:175-83. 1993
  9. ncbi Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cells
    A Mas
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Horm Metab Res 30:118-22. 1998
  10. pmc The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Mol Biol Cell 17:14-24. 2006

Research Grants

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  2. NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2016
  3. Impact of miR-495 vs. HuD in the Control of Addiction-Related Genes and Behavior
    NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013
  4. Fragile X Mental Retardation Protein translation regulator function: interactions
    MIHAELA R MIHAILESCU; Fiscal Year: 2013
  5. Dissecting the molecular basis of fragile X syndrome in Drosophila
    Peng Jin; Fiscal Year: 2011
  6. Kaylen Lott; Fiscal Year: 2015
  7. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
  8. Vivian Bellofatto; Fiscal Year: 2014
  9. VISWANATHAN PALANISAMY; Fiscal Year: 2016
  10. Xinbin Chen; Fiscal Year: 2016

Detail Information

Publications731 found, 100 shown here

  1. ncbi Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins
    D Penkov
    Brookdale Center in the Department of Biochemistry, Mount Sinai School of Medicine, New York, NY, USA
    Gene 243:27-36. 2000
    ..element of the alpha2(I) collagen promoter (Box 5A) has led to the identification of a novel gene product (RBMS3)...
  2. pmc RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1
    Dillon Fritz
    Department of Biomedical Science, College of Medicine, Florida State University, Tallahassee, FL 32306 4300, USA
    J Mol Biol 371:585-95. 2007
    ..Here, we show that expression of the RNA-binding protein RBMS3 is upregulated in the activation of HSCs and fibrotic livers...
  3. doi Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
    Yan Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 71:6106-15. 2011
    ..In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24...
  4. ncbi Reconstitution of human telomerase activity in vitro
    T L Beattie
    Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 8:177-80. 1998
    ..Substitution of conserved amino acid residues in the reverse transcriptase domain of TP2 completely abolished telomerase activity. We suggest that TP2 and hTR might represent the minimal catalytic core of human telomerase...
  5. pmc The essential yeast RNA binding protein Np13p is methylated
    C W Siebel
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Proc Natl Acad Sci U S A 93:13641-6. 1996
    ..Using a monoclonal antibody, 1E4, we have shown that the yeast NPL3 gene product Np13p, an essential RNA binding protein with repeated RGG motifs, is arginine-methylated in vivo...
  6. pmc A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm
    J Flach
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 14:8399-407. 1994
    ..This toxicity depends on the presence of series of unique repeats in the N terminus and localization to the nucleus. We suggest that the properties of Npl3 are consistent with it being involved in export of RNAs from the nucleus...
  7. pmc Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription
    F D Schubot
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 10:1980-8. 2001
    ..Based on the structure, we propose that the promoter specificity region is located on the mitochondrial RNA polymerase and that binding of sc-mtTFB indirectly mediates interaction of the core enzyme with the promoter site...
  8. ncbi The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting
    E M Ellis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
    Gene 132:175-83. 1993
    ..We have cloned and sequenced the wild-type allele of one of these genes (MTS1) and shown that it encodes a member of a family of RNA-binding proteins that is essential for growth...
  9. ncbi Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cells
    A Mas
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Horm Metab Res 30:118-22. 1998
    ..These domains could be targets for a RNA-binding protein induced by treatment with epinephrine producing a destabilization of IR mRNA in U-937 cells...
  10. pmc The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    Mol Biol Cell 17:14-24. 2006
    ..We also demonstrate that Sam68 shuttles between the nucleus and the cytoplasm in secondary spermatocytes, suggesting that it may promote translation of specific RNA targets during the meiotic divisions...
  11. ncbi Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S and suppresses its translation in vitro
    Juxiang Yang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 68:853-9. 2003
    ..These data suggest that TB-RBP is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis. Moreover, the Gapds mRNA is the first mRNA shown to have a functional TB-RBP binding site in its 5' UTR...
  12. pmc The evolution of core proteins involved in microRNA biogenesis
    Dennis Murphy
    Bioinformatics, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, Collegeville, Pennsylvania 19426, USA
    BMC Evol Biol 8:92. 2008
    ....
  13. ncbi Molecular characterization of a TIA-1-like RNA-binding protein in cells derived from the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae)
    Sayaka Muto
    Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo, Kyoto, Japan
    Biosci Biotechnol Biochem 73:648-56. 2009
    ....
  14. pmc The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of phage Q beta RNA
    P A Kaminski
    Unité de Physiologie Cellulaire, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 91:4663-7. 1994
    ..A null mutant, constructed by disruption of nrfA, exhibited the same phenotype as the missense mutant. Thus, an additional factor can be added to the already complex system of nifA regulation in A. caulinodans...
  15. pmc Posttranscriptional repression of GacS/GacA-controlled genes by the RNA-binding protein RsmE acting together with RsmA in the biocontrol strain Pseudomonas fluorescens CHA0
    Cornelia Reimmann
    Département de Microbiologie Fondamentale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne Dorigny, Switzerland
    J Bacteriol 187:276-85. 2005
    ..The transcription and stability of both regulatory RNAs were strongly reduced in the rsmA rsmE double mutant. In conclusion, RsmA and RsmE together account for maximal repression in the GacS/GacA cascade of strain CHA0...
  16. ncbi RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo
    Javier G De Gaudenzi
    Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, CONICET UNSAM, 1650 San Martin, Provincia de Buenos Aires, Argentina
    J Biol Chem 278:18884-94. 2003
    ..Altogether, these results suggest that TcRBPs might be modulated in vivo, to favor or preclude the interaction with specific transcripts in a developmentally regulated manner...
  17. pmc Xlrbpa, a double-stranded RNA-binding protein associated with ribosomes and heterogeneous nuclear RNPs
    C R Eckmann
    Department of Cytology and Genetics, Institute of Botany, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 138:239-53. 1997
    ..data and the overall organization of the protein suggest that Xlrbpa is the Xenopus homologue of human TAR-RNA binding protein (TRBP), a protein isolated by its ability to bind to human immunodeficiency virus (HIV) TAR-RNA...
  18. ncbi Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 409:389-98. 2008
    ....
  19. pmc Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1
    Y W Park
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:6694-9. 1999
    ....
  20. pmc Rrp5p, a trans-acting factor in yeast ribosome biogenesis, is an RNA-binding protein with a pronounced preference for U-rich sequences
    Paulo de Boer
    Section of Biochemistry and Molecular Biology, FEW, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    RNA 12:263-71. 2006
    ..cerevisiae spacer. The implications for the role of Rrp5p in yeast ribosome biogenesis are discussed...
  21. doi RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma
    Yung Ming Jeng
    Graduate Institute of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    Hepatology 48:1118-27. 2008
    ..Microarray analysis revealed that IMP3 depletion was associated with downregulation of multiple genes involved in tumor invasion...
  22. pmc The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro
    Jinwoo Ahn
    Department of Structural Biology, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Retrovirology 7:40. 2010
    Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) and influences the efficiency of viral reverse transcription (Lemay et al...
  23. doi Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cel
    Canan Doğanlı
    Department of Medical Biochemistry, Aarhus University, Aarhus C, Denmark
    DNA Cell Biol 29:713-27. 2010
    ..Despite the lack of a conserved nuclear localization signal, the C. elegans ZFR-GFP fusion protein also displayed an intranuclear localization in the 2-cell mouse embryo...
  24. ncbi Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrB
    T Romeo
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
    Mol Microbiol 29:1321-30. 1998
    ..The presence of csrA homologues in phylogenetically diverse species further suggests that this novel kind of regulatory system is likely to play a broad role in modulating eubacterial gene expression...
  25. pmc rsmC of the soft-rotting bacterium Erwinia carotovora subsp. carotovora negatively controls extracellular enzyme and harpin(Ecc) production and virulence by modulating levels of regulatory RNA (rsmB) and RNA-binding protein (RsmA)
    Y Cui
    Plant Sciences Unit, University of Missouri, Columbia, Missouri 65211, USA
    J Bacteriol 181:6042-52. 1999
    ..betavasculorum, and E. carotovora subsp. carotovora. These findings collectively support the idea that rsmA and rsmB expression in these plant pathogenic Erwinia species is controlled by RsmC or a functional homolog of RsmC...
  26. ncbi Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons
    Naila Ben Fredj
    Neurodégénérescence et Plasticité, INSERM EMI 01 08, Institut National de la Sante et de la Recherche Medicale, Pavillon de Neurologie, Centre Hospitalier Universitaire, 38043 Grenoble, France
    J Cell Sci 117:1079-90. 2004
    ..These results support the possible involvement of Sam68 in the activity-dependent regulation of dendritic mRNAs...
  27. pmc ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding protein
    Yaya Cui
    Department of Plant Microbiology and Pathology, University of Missouri, Columbia, 65211, USA
    J Bacteriol 187:4792-803. 2005
    ..carotovora have shown that AHL deficiency causes the production of high levels of RsmA, an RNA binding protein that functions as a global negative regulator of extracellular enzymes and proteins and secondary ..
  28. pmc The Arabidopsis thaliana double-stranded RNA binding protein DRB1 directs guide strand selection from microRNA duplexes
    Andrew L Eamens
    Commonwealth Scientific and Industrial Research Organisation Plant Industry, Canberra, Australian Capital Territory 2601, Australia
    RNA 15:2219-35. 2009
    In Arabidopsis thaliana (Arabidopsis), DICER-LIKE1 (DCL1) functions together with the double-stranded RNA binding protein (dsRBP), DRB1, to process microRNAs (miRNAs) from their precursor transcripts prior to their transfer to the RNA-..
  29. pmc Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis
    Peng Yuan Wang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 426:293-306. 2010
    ..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs...
  30. pmc Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
    Mark E Gill
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7443-8. 2011
    ..In C57BL/6 mice, Dazl is required for licensing. Licensing serves as a gateway from the embryonic processes shared between the sexes--germ cell specification and migration--to the sex-specific pathways of oogenesis and spermatogenesis...
  31. pmc Bovine coronavirus nonstructural protein 1 (p28) is an RNA binding protein that binds terminal genomic cis-replication elements
    Kortney M Gustin
    Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37996 0845, USA
    J Virol 83:6087-97. 2009
    ..These results together indicate that nsp1 is an RNA-binding protein that may function to regulate viral genome translation or replication but not by binding SLV-VI within its own coding region...
  32. pmc RNA-binding protein TIAR is essential for primordial germ cell development
    A R Beck
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:2331-6. 1998
    ..TIAR-deficient mice thus provide a model system to study molecular mechanisms of PGC development and possibly the basis for some forms of idiopathic infertility...
  33. pmc Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production
    Helen S Christensen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Virol 81:5121-31. 2007
    ..silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components...
  34. doi Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmology 116:1502-9. 2009
    ....
  35. ncbi Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast
    Naoko Mauchi
    Department of Molecular Cell Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai, Tsukuba, Japan
    Cell Struct Funct 35:95-105. 2010
    ..Our results suggest that MTL1 mRNA bears a cis-acting element involved in destabilization by the decapping enzyme and the 5'-3' exonuclease, and Khd1p stabilizes MTL1 mRNA through binding to this element...
  36. pmc HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells
    Qintong Li
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Nucleic Acids Res 35:2503-12. 2007
    ..Our study illuminates novel properties of HEXIM1 both in vitro and in vivo, and suggests that HEXIM1 may be involved in other nuclear and cytoplasmic processes besides controlling P-TEFb...
  37. ncbi Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification
    Y P Liu
    Department of Chemistry, Rutgers State University of New Jersey 08855 0939, USA
    Biol Signals 6:166-74. 1997
    ..Our study also suggests the possibility of using a gel mobility shift assay for eIF-5A-RNA binding as a functional assay for deoxyhypusine and hypusine formation...
  38. ncbi DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
    H A Drabkin
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
    Oncogene 18:2589-97. 1999
    DEF-3(g16/NY-LU-12) encodes a novel RNA binding protein isolated by positional cloning from an SCLC homozygous deletion region in 3p21.3 and, in parallel, as a differentially expressed gene during myelopoiesis from FDCPmix-A4 cells...
  39. ncbi The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
    Laetitia Davidovic
    Unite de Recherche en Genetique Humaine et Moleculaire, Centre de recherche Hôpital Saint François d Assise, le CHUQ, Quebec, Canada G1L 3L5
    Hum Mol Genet 15:1525-38. 2006
    ..We propose that this novel cellular partner for FMRP escorts FMRP-containing mRNP from the nucleus and nucleolus to the somato-dendritic compartment where it might participate in neuronal translation regulation...
  40. ncbi Ethanol inhibited apoptosis-related RNA binding protein, Napor-3 gene expression in the prenatal rat brain
    Nibedita Naha
    Division of Life Science, Applied Life Science BK 21, College of Natural Science, Gyeongsang National University, Jinju, South Korea
    Med Sci Monit 15:BR6-12. 2009
    ..The objective of the present study was to observe whether maternal ethanol exposure can alter gene expression pattern in mother and in fetus during mid and late prenatal stage...
  41. doi RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases
    Dengfeng Cao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 24:288-96. 2011
    ..03) and was therefore more sensitive. For primary extragonadal yolk sac tumors, combining LIN28 and SALL4 can achieve a higher diagnostic sensitivity than either alone...
  42. ncbi Part of Xenopus translin is localized in the centrosomes during mitosis
    A Castro
    Centre de Recherches de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, Montpellier Cedex 5, 34293, France
    Biochem Biophys Res Commun 276:515-23. 2000
    ..Interestingly, part of X-translin underwent a remarkable redistribution throughout mitosis and associated with centrosomes, which may suggest a new unknown role for this protein in cell cycle...
  43. pmc A family of cold-regulated RNA-binding protein genes in the cyanobacterium Anabaena variabilis M3
    N Sato
    Laboratory of Life Science, Tokyo Gakugei University, Japan
    Nucleic Acids Res 23:2161-7. 1995
    ..Gel-filtration assay showed that all of the Rbp proteins have higher affinities to poly(G) and poly(U) than to poly(A) and poly(C)...
  44. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
  45. doi Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors
    Kanako Susaki
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Exp Eye Res 88:347-55. 2009
    ..Studying the regulation of Msi1 and the target RNAs of Msi1 in photoreceptors and RPE cells might contribute to fundamental and clinical studies of retinal degeneration...
  46. ncbi Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    Christine Hostetter
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
    Cancer Biol Ther 7:1496-506. 2008
    ..We found that inhibition of JNK, a member of the MAPK family, decreases cytoplasmic accumulation of the RNA binding protein HuR...
  47. doi Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt
    Jun Kaneko
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8572, Japan
    Neurosci Lett 450:252-7. 2009
    ..All together, it is probable that Msi1 is one of the essential factors that need to be regulated in retinal regeneration...
  48. pmc Predicting RNA-binding residues from evolutionary information and sequence conservation
    Yu Feng Huang
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
    BMC Genomics 11:S2. 2010
    ..The ability to computationally predict RNA-binding residues in a RNA-binding protein can help biologists reveal important site-directed mutagenesis in wet-lab experiments...
  49. pmc A 69-kDa RNA-binding protein from Xenopus oocytes recognizes a common motif in two vegetally localized maternal mRNAs
    S P Schwartz
    Department of Anatomy and Embryology, Hebrew University Medical School, Jerusalem, Israel
    Proc Natl Acad Sci U S A 89:11895-9. 1992
    ..These data indicate that vegetally localized mRNAs share a binding motif that helps them achieve their intracellular distribution through specific RNA-protein interactions...
  50. ncbi Cloning and characterization of cold-regulated glycine-rich RNA-binding protein genes from leafy spurge (Euphorbia esula L.) and comparison to heterologous genomic clones
    D P Horvath
    U S Department of Agriculture, Agricultural Research Service, State University Station, Fargo, ND 58105 5674, USA
    Plant Mol Biol 38:531-8. 1998
    ..These transcripts are induced in response to low temperatures in roots, stems and leaves, but are expressed constitutively in tissue culture at control temperatures...
  51. pmc Evidence for 3' untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAV
    M L Samson
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Genetics 150:723-33. 1998
    ..I discuss the implications of these results for normal elav function...
  52. pmc Identification of Gbp2 as a novel poly(A)+ RNA-binding protein involved in the cytoplasmic delivery of messenger RNAs in yeast
    Merle Windgassen
    Philipps University Marburg, Institute for Molecular Biology and Tumor Research, Emil Mannkopff Strasse 2, 35037 Marburg, Germany
    EMBO Rep 4:278-83. 2003
    ..Together, our findings clearly show an involvement of Gbp2 in mRNA transport. In addition, as a non-essential protein, Gbp2 also has the interesting potential to be spatially or temporally regulated...
  53. ncbi Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis
    Zhe Peng
    Program in Molecular and Cellular Biology, State University of New York Health Science Center at Brooklyn, Department of Microbiology and Immunology, Morse Institute for Molecular Biology and Genetics, Brooklyn, NY 11203, USA
    Curr Genet 43:178-85. 2003
    ..Notably, induced levels of mei2 are not a prerequisite for meiotic differentiation, as previously thought. The implications of this result to developmental regulation are discussed...
  54. ncbi Phosphorylation influences the translation state of FMRP-associated polyribosomes
    Stephanie Ceman
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 12:3295-305. 2003
    ..FMRP is a nucleocytoplasmic RNA binding protein that is primarily associated with polyribosomes...
  55. ncbi The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2
    Andrea Haegebarth
    Departments of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 279:54398-404. 2004
    ..The ability of BRK/Sik to negatively regulate the RNA-binding activities of the KH domain RNA binding proteins SLM-1 and Sam68 may have an impact on the posttranscriptional regulation of epithelial cell gene expression...
  56. ncbi A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans
    Peter R Boag
    Joslin Diabetes Center and Department of Pathology, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Development 132:4975-86. 2005
    ..We propose that this cell death pathway facilitates the formation of functional oocytes, possibly by monitoring specific cytoplasmic events during oogenesis...
  57. ncbi Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway
    Uwe Irion
    The Gurdon Institute, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QN, UK
    Dev Biol 297:522-33. 2006
    The double-stranded RNA binding protein Staufen is required for the microtubule-dependent localization of bicoid and oskar mRNAs to opposite poles of the Drosophila oocyte and also mediates the actin-dependent localization of prospero ..
  58. pmc Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    Mika Nakamoto
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15537-42. 2007
    ....
  59. pmc STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo
    Genta Ohno
    Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Genes Dev 22:360-74. 2008
    ..We propose that the developmental switching between alternative sequences of intron removal determines the ratio between the mature let-2 mRNA isoforms...
  60. ncbi DAZL binds to the transcripts of several Tssk genes in germ cells
    Mei Zeng
    Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, 610041, PR China
    BMB Rep 41:300-4. 2008
    ..Our results suggest that the Dazl gene may play different roles in human and mouse spermatogenesis by regulating different members of the downstream gene family...
  61. pmc Autoinhibition of human dicer by its internal helicase domain
    Enbo Ma
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3206, USA
    J Mol Biol 380:237-43. 2008
    ..Modest stimulation of catalysis by the full-length Dicer enzyme was observed in the presence of the TAR-RNA binding protein, which physically interacts with the DExD/H-box domain...
  62. pmc Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2
    Kimberly B Zumbrennen
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell Biol 29:2219-29. 2009
    ..These studies provide insight into the structural basis for IRP2-RNA interactions and reveal an iron-independent mechanism for regulating iron homeostasis through the redox regulation of IRP2 cysteines...
  63. pmc 3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells
    Sandip K Basu
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, NIH, MD, USA
    EMBO J 30:3714-28. 2011
    ..Our findings reveal a novel mechanism whereby non-coding mRNA sequences selectively regulate C/EBPβ activity and suppress its anti-oncogenic functions...
  64. pmc A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing
    Helen L Lightfoot
    Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
    Biochemistry 50:7514-21. 2011
    ..The data support a mechanism by which LIN28 can directly inhibit let-7g biogenesis at the Dicer processing step...
  65. pmc Glycogen synthase kinase-3: a promising therapeutic target for fragile x syndrome
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Birmingham, AL, USA
    Front Mol Neurosci 4:35. 2011
    ..FMRP may have several functions, but it is most well-established as an RNA binding protein that regulates translation, and it is thought that by this mechanism FMRP is capable of affecting numerous ..
  66. doi Identification of phosphoproteins in Arabidopsis thaliana leaves using polyethylene glycol fractionation, immobilized metal-ion affinity chromatography, two-dimensional gel electrophoresis and mass spectrometry
    Uma K Aryal
    Plant Biotechnology Institute, National Research Council, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N 0W9
    J Proteome Res 11:425-37. 2012
    ....
  67. pmc The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues
    Yuko Sukegawa
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002387. 2011
    ..This study also demonstrates clearly that the stress-responsive MAP kinase pathway can modulates gene expression through phosphorylation of Pol II CTD...
  68. doi A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA
    Yingqun Huang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Wiley Interdiscip Rev RNA 3:483-94. 2012
    ..Recent advances in our understanding of Lin28-mediated mechanisms of posttranscriptional regulation of gene expression reveal important roles of this protein in the fields of development, stem cells, metabolic diseases, and cancer...
  69. doi An ABA-regulated putative RNA-binding protein affects seed germination of Arabidopsis under ABA or abiotic stress conditions
    Hyun Ju Jung
    Department of Plant Biotechnology and Kumho Life Science Laboratory, College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju, 500 757, Republic of Korea
    J Plant Physiol 170:179-84. 2013
    ....
  70. pmc CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness
    Bruno Pereira
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, 4200 465 Porto, Portugal
    Nucleic Acids Res 41:3986-99. 2013
    ....
  71. pmc Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules
    Cristina Gareau
    Department of Molecular Biology, Medical Biochemistry, and Pathology, Faculty of Medicine, Laval University, Centre de recherche le CHU de Quebec, Quebec, Canada
    PLoS ONE 8:e55342. 2013
    ..To our knowledge, this is the first demonstration of the regulated shuttling activity of a SG component between RNA granules and the cytosol...
  72. pmc Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells
    Shankung Lin
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
    PLoS ONE 8:e58227. 2013
    ..In sum, we have shown that PTB plays as a negative regulator in H1299 cell proliferation at least by inducing p19(Ink4d) expression at transcriptional and post-transcriptional levels...
  73. pmc The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP
    Hua Lin Zhou
    Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genes Dev 27:1046-58. 2013
    ..Our studies reveal a new paradigm in RNA biology: nondegradative ubiquitin signaling-dependent disassembly of mRNP promoted by the p97-UBXD8 complex to control mRNA stability...
  74. doi RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
    Ryoko Ihara
    Department of Neuropathology, Graduate School of Medicine
    Hum Mol Genet 22:4474-84. 2013
    ..Altogether, our results suggest that RNA binding is key to the neurodegeneration caused by overexpression of TDP-43, and that abnormalities in RNA processing may be crucial to the pathogenesis of TDP-43 proteinopathy. ..
  75. doi The RNA chaperone and protein chaperone activity of Arabidopsis glycine-rich RNA-binding protein 4 and 7 is determined by the propensity for the formation of high molecular weight complexes
    Ji Hoon Han
    Department of Plant Biotechnology, College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong Dong, Buk Gu, Kwangju, 500 757, Korea
    Protein J 32:449-55. 2013
    ..Taken together, these results show that the formation of HMW complexes is important for determining the RNA chaperone and protein chaperone activity of AtGRP4 and AtGRP7. ..
  76. doi Characterization of a plant (rice) translin and its comparative analysis with human translin
    Rajani Kant Chittela
    Biomolecular Damage and Repair Section, Molecular Biology Division, Bhabha Atomic Research Center, Trombay, Mumbai, 400085, India
    Planta 240:357-68. 2014
    ..Understanding the translin biology from plant systems will give the new insights into its functional role during plant development...
  77. pmc The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA
    Yuko Shimizu
    From the Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1 7 1, Kohnodai, Ichikawa, Chiba 272 8516, Japan
    J Biol Chem 289:26226-38. 2014
    ..Collectively, these data indicate that hnRNPQ6 promotes the interaction of APOBEC1 with IL8 mRNA and the subsequent increase in IL8 production. ..
  78. pmc Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA
    Y Kuwano
    Department of Stress Science, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima 770 8503, Japan
    Cell Death Differ 22:815-25. 2015
    ..Taken together, our findings suggest that Tra2β regulates apoptosis by modulating Bcl-2 expression through its competition with miR-204. This novel function may have a crucial role in tumor growth. ..
  79. pmc Applications of Cas9 as an RNA-programmed RNA-binding protein
    David A Nelles
    Department of Cellular and Molecular Medicine, Stem Cell Program, and Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA
    Bioessays 37:732-9. 2015
    ..We discuss potential uses ranging from live imaging of transcriptional dynamics to patient-specific therapies and applications in synthetic biology. ..
  80. doi Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer
    Hidekazu Takahashi
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Mol Cancer Ther 14:1705-16. 2015
    ..These findings indicated that PTBP1 is a potential therapeutic target for colorectal cancer...
  81. pmc Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
    Mei Yang
    Department of Genetics, Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Development 142:1616-27. 2015
    ..Thus, Lin28a and Lin28b have overlapping functions in temporally regulating NPC proliferation during early brain development. ..
  82. pmc Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons
    Xia Sun
    Univ Paris Sud, Centre de Neurosciences Paris Sud, UMR 8195, Orsay, 91405 France CNRS UMR 8195, Univ Paris Sud, Orsay, 91405 Cedex, France
    G3 (Bethesda) 5:2865-74. 2015
    ..We argue that this regulation may have important sexually dimorphic consequences for the regulation of nervous system development or function. ..
  83. pmc Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS
    Suharsh Shah
    From the Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
    J Biol Chem 291:110-25. 2016
    ..In summary, these data illustrate why understanding the competing effects of feedback and feed-forward control is relevant to the development of novel anti-inflammatory therapies. ..
  84. pmc Musashi mediates translational repression of the Drosophila hypoxia inducible factor
    Agustina P Bertolin
    Instituto Leloir, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Nucleic Acids Res 44:7555-67. 2016
    ..In this study, we have identified the RNA binding protein dMusashi, as a negative regulator of the fly HIF homologue Sima...
  85. pmc Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold
    Xinzhou Zhu
    University Children s Hospital Basel UKBB, Spitalstrasse 33, 4056, Basel, Switzerland
    Cell Mol Life Sci 73:3839-59. 2016
    ....
  86. ncbi A Small-Molecule Inhibitor of Lin28
    Martina Roos
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    ACS Chem Biol 11:2773-2781. 2016
    ..In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an RNA binding protein (RBP) Lin28, which docks onto a conserved sequence in let-7 precursor RNA molecules and prevents their ..
  87. pmc Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing
    Piergiorgio La Rosa
    Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
    elife 5:. 2016
    ..Our study identifies Sam68 as a key regulator of NPC self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex...
  88. ncbi who encodes a KH RNA binding protein that functions in muscle development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Development 124:1323-32. 1997
    ..These results indicate that who plays an essential role in steroid regulation of muscle development...
  89. pmc Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein
    M Tolnay
    Department of Clinical Physiology, Walter Reed Army Institute of Research, 14th and Dahlia Streets, Bldg 40, Washington, DC 20307 5100, USA
    Biochem J 338:417-25. 1999
    ..Our results suggest a new physiological role for hnRNP D0B that involves binding to double- and single-stranded DNA sequences in a specific manner and functioning as a transcription factor...
  90. ncbi MEC-8 regulates alternative splicing of unc-52 transcripts in C. elegans hypodermal cells
    Caroline A Spike
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis 55455, USA
    Development 129:4999-5008. 2002
    ..Indeed, our analysis of unc-52 genetic mosaics has shown that the focus of unc-52 action is not in body-wall muscle but most likely is in hypodermis...
  91. pmc Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action
    V Sanchez-Margalet
    Department of Clinical Biochemistry, Investigation Unit, University Hospital Virgen Macarena, Seville, Spain
    Clin Exp Immunol 133:11-9. 2003
    ..Moreover, these immunoregulatory functions of leptin could have some relevance in the pathophysiology of obesity...
  92. ncbi The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis
    Deborah Wessels
    W M Keck Dynamic Image Analysis Facility, Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 119:370-9. 2006
    ..In light of these results, we discuss how SBDS might function during chemotaxis...
  93. ncbi Spatiotemporal localization of germ plasm RNAs during zebrafish oogenesis
    Kyoko Kosaka
    Department of Biology, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
    Mech Dev 124:279-89. 2007
    ..Furthermore, we propose that the germ plasm components are assembled in a stepwise and spatiotemporally-regulated manner during oogenesis and early embryogenesis in zebrafish...
  94. pmc Frequency and fate of microRNA editing in human brain
    Yukio Kawahara
    The Wistar Institute
    Nucleic Acids Res 36:5270-80. 2008
    ..Our studies predict that approximately 16% of human pri-miRNAs are subject to A-->I editing and, thus, miRNA editing could have a large impact on the miRNA-mediated gene silencing...
  95. pmc Intracellular localization of hepatitis delta virus proteins in the presence and absence of viral RNA accumulation
    Ziying Han
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 83:6457-63. 2009
    Hepatitis delta virus (HDV) encodes one protein, hepatitis delta antigen (deltaAg), a 195-amino-acid RNA binding protein essential for the accumulation of HDV RNA-directed RNA transcripts...
  96. pmc IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1
    Yijiang Shi
    Division of Hematology Oncology, University of California at Los Angeles Greater Los Angeles Veterans Affairs Healthcare Center, Jonnsson Comprehensive Cancer Center, Los Angeles, California 90073, USA
    J Biol Chem 286:67-78. 2011
    ..Thus, IL-6 activates c-Myc translation in MM cells by inducing A1 phosphorylation and cytoplasmic localization in a p38-dependent fashion. These data suggest A1 as a potential therapeutic target in MM...
  97. pmc Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms
    Kelly A France
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Biol Chem 286:22750-7. 2011
    Ewing family tumors are characterized by a translocation between the RNA binding protein EWS and one of five ETS transcription factors, most commonly FLI1...
  98. pmc Activity-dependent FUS dysregulation disrupts synaptic homeostasis
    Chantelle F Sephton
    Departments of Neuroscience and Institut Universitaire en Santé Mentale de Québec, Department of Psychiatry and Neuroscience, Universite Laval, Quebec City, QC, Canada G1J 2G3
    Proc Natl Acad Sci U S A 111:E4769-78. 2014
    ....
  99. pmc Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas
    Xian Liu
    Department of Reproductive Medicine, The First Affiliated Hospital of the Medical College, Xi an Jiaotong University, Xi an, The People s Republic of China
    Oncotarget 5:10870-85. 2014
    ..Our findings provide new evidence that Msi1 might promote cell proliferation by accelerating the cell cycle by directly targeting p21, p27 and p53. ..
  100. doi Progress on the relationship between miR-125 family and tumorigenesis
    Hang Yin
    Dalian 24 High School, Dalian 116023, China
    Exp Cell Res 339:252-60. 2015
    ..like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al...
  101. ncbi Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice
    R J Hardy
    Brookdale Center for Molecular Biology, Mount Sinai Medical Center, New York, New York 10029, USA
    J Neurosci 16:7941-9. 1996
    ..These observations implicate QKI proteins as regulators of myelination and reveal key insights into the mechanisms of dysmyelination in the quakingviable mutant...

Research Grants104 found, 100 shown here

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2016
    ..Our research suggests that the RNA binding protein HuD and the microRNA miR-495 play opposite roles in the control of addiction-related gene expression and ..
  3. Impact of miR-495 vs. HuD in the Control of Addiction-Related Genes and Behavior
    NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2013
    ..A better understanding of these regulatory mechanisms is a pre-requisite for the application of these new tools in addiction research and ultimately in the treatment of this disorder. ..
  4. Fragile X Mental Retardation Protein translation regulator function: interactions
    MIHAELA R MIHAILESCU; Fiscal Year: 2013
    ..FMRP is an RNA binding protein involved in the transport and translation regulation of specific messenger RNA (mRNA) targets...
  5. Dissecting the molecular basis of fragile X syndrome in Drosophila
    Peng Jin; Fiscal Year: 2011
    ..abstract_text> ..
  6. Kaylen Lott; Fiscal Year: 2015
    ..Overall, the proposed experiments will provide insight into the functions of an essential RBP in T. brucei and elucidate how arg methylation can modulate these functions. ..
  7. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    ..This research tests the hypothesis that large RNP granules play a protective role in maintaining oocyte viability and fertility and may be relevant to understanding the basis for infertility that occurs as women age. ..
  8. Vivian Bellofatto; Fiscal Year: 2014
    ..brucei. This exploratory, two-year project is grounded in preliminary data, in a recent publication from our laboratory, preliminary data and complementary in vivo molecular genetic and in vitro biochemical approaches. ..
  9. VISWANATHAN PALANISAMY; Fiscal Year: 2016
    ..Thus, our data will provide a foundation for understanding the role of HuR in oral mucositis-associated gene regulation and will be pivotal for future studies into HuR-associated oral diseases. ..
  10. Xinbin Chen; Fiscal Year: 2016
    ....
  11. Michael Cleary; Fiscal Year: 2016
    ..This work will generate a comprehensive and predictive network map of neural mRNA decay dynamics, thus filling a significant gap in current models of gene expression during neural development. ..
  12. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2013
    The broad goal of the project is to understand the mechanisms by which RNA binding protein RBM3 regulates gene expression at the posttranscriptional level of mRNA stability and translation in cancer cells...
  13. Kelsey C Martin; Fiscal Year: 2014
    ..For example, mutations in Fragile X Mental Retardation protein, an RNA binding protein involved in RNA trafficking and translational regulation at the synapse, represent the most common single ..
  14. Encyclopedia of C elegans 3'UTRS and their regulatory elements
    Fabio Piano; Fiscal Year: 2011
    ..elegans by identifying all the 3'UTRs (sequence elements that regulate gene expression) as well as dissect the 3'UTRs and identify sub-elements that are responsible for the 3'UTR's functions. ..
  15. Circadian regulation of microRNA biogenesis and function
    Peter W Vanderklish; Fiscal Year: 2012
    ..In light of emerging data that disruptions in circadian rhythm and miRNA expression underlie many disease states, our studies should provide important insights into disease-related processes of the nervous system. ..
  16. MOLECULAR CLONING OF THE FRAGILE X SITE
    Stephen T Warren; Fiscal Year: 2011
    ..Deep fundamental knowledge of a disease is the best course toward eventual therapeutics. ..
  17. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..Aim 2: To test the hypothesis that the RNA binding protein HuR regulates the ontogeny of ASBT via changes in mRNA stability...
  18. Richard I Gregory; Fiscal Year: 2016
    ..These studies are relevant to the treatment of cancer, diabetes, developmental disorders and numerous degenerative diseases. ..
  19. A novel therapy for HER2 positive hormone refractory breast cancer
    Anne W Hamburger; Fiscal Year: 2010
    ..As several independent groups have demonstrated that EBP1 is both a DNA and RNA binding protein, we will examine effects on EBP1 on ErbB2 transcription and post-transcriptional events...
  20. Joseph Avruch; Fiscal Year: 2016
    ..Among them is an RNA binding protein IMP2, first discovered by its ability to bind to an IGF2 mRNA expressed primarily in fetal life, whose ..
  21. Valérie A Schumacher; Fiscal Year: 2016
    ..Two major foci will be on the role of the RNA binding protein Staufen 2 in regulating mRNA localization in podocytes and the role of Staufen 2 and Staufen 2-associated ..
  22. Vandana Gupta; Fiscal Year: 2016
    ..Genetic mapping in osoi fish identified a 20 base pair deletion in a novel DEAD-box RNA helicase, a RNA binding protein, resulting in a frameshift mutation. Dr...
  23. Tony Romeo; Fiscal Year: 2016
    ..CsrA is an RNA binding protein that regulates mRNA translation and stability...
  24. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..target AU-rich sequences, and requires LFA-1 engagement-induced nuclear-to-cytoplasmic translocation of the RNA binding protein HuR...
  25. RNA Binding Protein CUGBP2 in Intestinal Epithelium
    Shrikant Anant; Fiscal Year: 2010
    ..provided by applicant): The broad goal of this application is to understand the mechanisms by which RNA binding protein CUGBP2 regulates gene expression at the posttranscriptional level of mRNA stability and translation in ..
  26. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ....
  27. Post-transcriptional control of inflammatory gene expression
    Thomas A Hamilton; Fiscal Year: 2013
    ..This proposal is focused upon understanding the mechanisms through which IL-17 (and other stimuli) controls degradation of specific inflammation related messenger RNAs and thereby modulates aspects of inflammatory response. ..
  28. Posttranscriptional Gene Regulation in Asthma
    Ulus Atasoy; Fiscal Year: 2010
    ..Our central hypothesis is that the RNA binding protein, HuR, is coordinately regulating IL-4 and IL-13 cytokine genes during allergen driven asthma...
  29. Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1
    Blanche Capel; Fiscal Year: 2013
    ..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..
  30. AMBROSE LIN YAU CHEUNG; Fiscal Year: 2016
    ..Accordingly, MazFsa and "specific RNA binding proteins" represent novel targets for antibiotic development. As TA systems, DEAD-box and other RNA binding proteins are common in prokaryotes, our results may apply to other pathogens. ..
  31. DAVID IRWIN GREENSTEIN; Fiscal Year: 2014
    ..The small roundworm C. elegans is an established model for studying the hormonal control of meiosis. These studies will define the signaling mechanisms controlling female meiosis and provide insights into the origin of meiotic errors. ..
  32. Anand Venugopal; Fiscal Year: 2015
    ..RNA binding motif 3 (RBM3) is an RNA binding protein that is expressed in the intestinal epithelial cells...
  33. REGULATION OF SYNAPSE ELIMINATION BY FMRP
    JULIA RIVES WILKERSON; Fiscal Year: 2011
    ..The results of these experiments may lead to the development of new therapies for autism and mental retardation disorders. ..
  34. A structure-function analysis of let-7g miRNA regulation by Lin28
    CHRISTINA ROSE MOZES; Fiscal Year: 2012
    ....
  35. Ulus Atasoy; Fiscal Year: 2016
    ..Our hypothesis is that the RNA binding protein, HuR, is coordinately regulating Th2 polarization and cytokine gene expression in allergic airway ..
  36. Christopher J Rhodes; Fiscal Year: 2014
    ..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
  37. Keith L Kirkwood; Fiscal Year: 2015
    ..These studies will establish the role of a key RNA binding protein in experimental models and human periodontitis...
  38. Kimberly Huber; Fiscal Year: 2015
    ..Fmr1 encodes a neuronal RNA binding protein, Fragile X Mental Retardation Protein (FMRP) 6...
  39. The toxicity of the RNA CGG repeats in FXTAS
    Lubov T Timchenko; Fiscal Year: 2013
    ..The identification of the early toxic events which trigger progression of FXTAS will provide a basis for the development of the therapeutic approaches for FXTAS. ..
  40. RNA-binding Protein HuR in Allergic Inflammation
    Cristiana Stellato; Fiscal Year: 2009
    ..abstract_text> ..
  41. Jennifer C Darnell; Fiscal Year: 2016
    ....
  42. Maha Abdellatif; Fiscal Year: 2014
    ..2) Examine the mechanisms of function of miR-21 and its target genes, FasL and PTEN, in cardiac myocytes. 3) Study the function of miR-21 and its regulation in vivo. ..
  43. DANIEL BATTLE; Fiscal Year: 2015
    ..Finally, we will define how Gemin5 controls gene expression in SMA by using neuronal cells with reduced SMN and an SMA mouse model. ..
  44. Presynaptic Fragile X Proteins
    Michael R Akins; Fiscal Year: 2011
    ..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
  45. RONALD ANTHONY DEPINHO; Fiscal Year: 2016
    ..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
  46. RONALD ANTHONY DEPINHO; Fiscal Year: 2014
    ..the master regulators of mitochondrial biogenesis and p53-directed activation of Quaking (QK), a RNA binding protein which we show is a potent tumor suppressor and regulator of microRNA-directed control of the key ..
  47. METABOLIC CONTROL OF PROINSULIN BIOSYNTHESIS TRANSLATION
    Christopher Rhodes; Fiscal Year: 2009
    ..Indeed, in the spirit of translational medicine, the feasibility of such a strategy will also be examined in preclinical models in this proposal. ..
  48. Abigail Renoux; Fiscal Year: 2014
    ....
  49. ADAM JOHN HARRINGTON; Fiscal Year: 2015
    ..With synapse elimination defects observed in autism and FXS, we believe that our studies will significantly enhance our understanding of the neurobiology in these complex diseases. ..
  50. Role of RNA Binding Proteins in BCR/ABL Leukemogenesis
    Danilo Perrotti; Fiscal Year: 2012
    ..If the proposed studies will determine modulation of RNA binding protein expression and function antagonize disease progression and efficiently induce apoptosis in the leukemia-..
  51. Xinyu Zhao; Fiscal Year: 2016
    ..learning and present us a unique opportunity for understanding the specific roles and functional impact of RNA binding protein- mediated translational regulation in postnatal/adult neurogenesis and learning disabilities...
  52. Vladimir S Spiegelman; Fiscal Year: 2016
    ..2. To delineate the mechanism(s) of CRD-BP regulation by hypoxia. 3. To analyze the (patho)physiologic significance of CRD-BP regulation by hypoxia in melanocytes. ..
  53. Mechanisms of MEF2-dependent synapse elimination
    CARLY FENWICK HALE; Fiscal Year: 2013
    ....
  54. Laurie R Earls; Fiscal Year: 2014
    ..Dgcr8 is a double-stranded RNA binding protein important for microRNA biosynthesis...
  55. Michael R Akins; Fiscal Year: 2015
    ..FXS is caused by mutations in the gene encoding the RNA binding protein FMRP. In the absence of FMRP, synaptic plasticity is altered...
  56. Gene-centered protein-RNA interaction mapping
    ALBERTHA JOHANNA WALHOUT; Fiscal Year: 2012
    ..RAPID is based on translation and mimics endogenous RNA binding protein activity...
  57. Piotr Sliz; Fiscal Year: 2016
    ..Finally, elucidating how Lin28 inhibits microRNA processing will also provide new information on the mechanism of central events in microRNA processing. ..
  58. The Regulation of UPA and UPAR in Human Carcinoma Cells
    Shuang Huang; Fiscal Year: 2010
    ..Also, gaining further understanding of the novel role of SECp43 in repressing uPA expression may lead to the development of a novel therapeutic approach to suppress tumor growth and metastasis. ..
  59. Carol J Wilusz; Fiscal Year: 2014
    ..Overall, we hope to elucidate the fundamental molecular changes that occur in myotonic dystrophy and identify novel targets for future therapeutics. ..
  60. Small RNAs in Stem Cell Differentiation and Neural Development
    Robert H Blelloch; Fiscal Year: 2010
    ..This model is based on the conditional deletion of the RNA binding protein DGCR8, which is required for the processing of pri- to pre-microRNAs...
  61. Lindy A McClelland; Fiscal Year: 2015
    ..I have identified the RNA binding protein Tis11 as an inhibitor of stem cell proliferation that is specifically expressed in stem cells...
  62. Leonard K Kaczmarek; Fiscal Year: 2015
    ....
  63. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..Increased knowledge of the mechanism by which IRP2 regulates iron balance and cell proliferation is important for developing therapeutics that can be used to target cancer cells and treat iron disorders. ..
  64. Paul Sumby; Fiscal Year: 2014
    ..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..
  65. Clinton C MacDonald; Fiscal Year: 2015
    ..Using a variety of techniques, we want to learn the molecular causes of why sperm production fails in males missing the CSTF2T gene, to better understand how to assist these infertile couples. ..
  66. Characterizing gene regulation with single molecule sensitive probes
    Philip J Santangelo; Fiscal Year: 2013
    ..activity of cancer cells by assessing mRNAs already transcribed, and 2) by characterizing mRNA/RNA binding protein interactions in the cellular/tissue milieu...
  67. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
  68. Haining Zhu; Fiscal Year: 2014
    ..The findings are expected to provide critical insights into the mechanisms by which FUS mutations perturb the RNA processing pathways and ultimately lead to the disease. ..
  69. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
    ....
  70. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..We hypothesize that formation of SGs is initiated through heat-induced aggregation of the RNA binding protein TIA-1, and that SGs in turn activate JNKs through a tumor necrosis factor (TNF) receptor-associated factor ..
  71. Thomas A Cooper; Fiscal Year: 2016
    ..expanded repeat RNA activates protein kinase C (PKC) and induces PKC-dependent phosphorylation of a second RNA binding protein, CUG-binding protein 1 (CUGBP1), resulting in its stabilization and up-regulation...
  72. Mahlon Collins; Fiscal Year: 2014
    ..performed a cerebrospinal fluid (CSF)-based proteomics study of ALS patients and identified the novel RNA binding protein RBM45 as a putative disease biomarker...
  73. SARA MARIE RASER PALMER; Fiscal Year: 2014
    ..mutans. Aim 2. Investigate the role of small RNAs, a ribonuclease, and an RNA binding protein encoded within the yidC gene clusters in the regulation of yidC expression and function of the YidC ..
  74. Kimberly Huber; Fiscal Year: 2016
    ..We find that the RNA binding protein, Fragile X Mental Retardation Protein (FMRP) is required for MEF2- triggered synapse elimination by ..
  75. Michael Rosbash; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): A new tool for the cell-specific identification of RNA binding protein targets. This proposal has its origins in my interest in post-transcriptional regulation in the Drosophila circadian system...
  76. Adam P Geballe; Fiscal Year: 2016
    ..In addition to aiding the development of the animal models, these studies will provide insights into the fundamental roles and evolution of dsRNA-binding proteins found in many viral systems. ..
  77. Andrew Berglund; Fiscal Year: 2014
    ..gain-of-function mechanism;the expanded CUG and CCUG repeat RNAs act as toxic RNAs to sequester MBNL1, a RNA binding protein, and also indirectly increase the protein levels of CUGBP1, another RNA binding protein, which disrupts the ..
  78. Sally Temple; Fiscal Year: 2015
    ..In Drosophila, Staufen is a double-stranded RNA binding protein that carries the mRNA of determinants such as Prospero, and is asymmetrically segregated from the stem-like ..
  79. CALLIE PREAST WIGINGTON; Fiscal Year: 2014
    ..This study will provide insight into the role of poly (A) RBPs such as ZC3H14 as post-transcriptional regulatory players and their potential involvement in breast cancer. ..
  80. CHRISTOPHER JOACHIM LENGNER; Fiscal Year: 2016
    ..In neuroblasts of Drosophila melanogaster this process is governed by the activity of the Musashi RNA binding protein, whose mammalian orthologs, Msi1 and Msi2, are highly expressed in mammalian intestinal stem cells and in ..
  81. Post-transcriptional regulation of gene expression in major TDP43 diseases
    NEIL MACDONALD RENWICK; Fiscal Year: 2013
    ..This research is relevant to NIH's mission to pursue fundamental knowledge and goal to foster innovative research strategies and their applications to advance the Nation's capacity to protect and improve health. ..
  82. James Umen; Fiscal Year: 2014
    ..RB) tumor suppressor pathway, a cyclin dependent kinase, CDKG1, that phosphorylates RB, and an RNA binding protein, TNY1...
  83. Anita H Corbett; Fiscal Year: 2016
    ..gene, which encodes a ubiquitously expressed, evolutionarily conserved, zinc finger, nuclear polyadenosine RNA binding protein (Pab), that cause an autosomal recessive form of non- syndromic intellectual disability (previously termed ..
  84. Craig E Cameron; Fiscal Year: 2016
    ....
  85. Jennifer Davis; Fiscal Year: 2014
    ....
  86. POSTTRANSCRIPTIONAL REGULATION OF ANTIOXIDANT ENZYMES
    LINDA CLERCH; Fiscal Year: 2002
    ....
  87. DAVID JOSEPH WEBER; Fiscal Year: 2016
    ..Our preliminary data indicate that the stress-activated RNA binding protein hnRNP A18 confers growth advantage to cancer cells by regulating the expression of key proteins that ..
  88. JOHN BRENNER; Fiscal Year: 2015
    ..of gld-1 are known: FBF-1 and FBF-2 are RNA-binding proteins that directly repress gld-1, whereas the RNA binding protein GLD-3, the poly-A polymerases GLD-2 and GLD-4, and NOS-3 activate gld-1...
  89. ARNALDO CARREIRA; Fiscal Year: 2014
    ..We anticipate that these efforts will improve our knowledge of the human RBFOX1 function and possibly its role in human pathogenesis. ..
  90. Jacob C Schwartz; Fiscal Year: 2014
    ..abstract_text> ..
  91. Michael Emmerson Ward; Fiscal Year: 2015
    ..TDP-43 is a DNA/RNA binding protein that is normally concentrated in the nucleus...
  92. STRUCTURES OF RNA BINDING PROTEINS FROM INFLUENZA VIRUS
    Gaetano Montelione; Fiscal Year: 2000
    ..These analogs will have great significance both in fundamental studies as well as in treating (or in developing drugs for) obesity, hypertension and failing heart. ..
  93. FMRP-regulated association of specific miRNAs with RISC
    BART RUSSELL ANDERSON; Fiscal Year: 2013
    ....
  94. Tilman Heise; Fiscal Year: 2015
    ..Ultimately, such knowledge might be translated into new therapeutic strategies targeting the expression of tumor-promoting factors in cancer. ..
  95. Mechanism of cell size checkpoint control by a Musahi-like RNA binding protein
    Bradley J S C Olson; Fiscal Year: 2010
    ..This proposal focuses on an RNA binding protein, TNY1, which regulates the size checkpoint pathway through MAT3/RB...
  96. BRUCELLA STATIONARY PHASE GENE EXPRESSION AND VIRULENCE
    ROY M ROOP; Fiscal Year: 2010
    Hfq is an RNA binding protein that plays multiple roles in the post-transcriptional regulation of gene expression in bacteria...
  97. Functional studies of the Fragile X Mental Retardation Protein: switching from re
    Mihaela Mihailescu; Fiscal Year: 2009
    ..FMRP is an RNA binding protein believed to be involved in the transport and translation regulation of specific messenger RNA (mRNA) ..
  98. THYROID/RETINOIC ACID RECEPTOR INTERACTING PROTEINS
    Mukul Mathur; Fiscal Year: 2004
    ..The 65 kDa protein is a RNA binding protein TLS, that was originally identified as part of a fusion protein associated with human myxoid liposarcoma...
  99. ELAV-LIKE PROTEINS IN NEUROBLASTOMA
    Susan Cohn; Fiscal Year: 2000
    ..Thus, ultimately, these studies may provide the clues necessary for the development of effective therapy for children with NB tumors that express high levels of N-myc and are clinically aggressive. ..
  100. Role of an RNA-Binding Protein in Mammary Carcinogenesis
    Jeffrey Ross; Fiscal Year: 2009
    ..By investigating the oncogenic properties of the CRD-BP, the RNAs it affects in vivo, and its interactions with tumor-inducing genetic and environmental factors, we hope to uncover novel tumorigenesis pathways. ..