RBFOX1

Summary

Gene Symbol: RBFOX1
Description: RNA binding protein, fox-1 homolog 1
Alias: 2BP1, A2BP1, FOX-1, FOX1, HRNBP1, RNA binding protein fox-1 homolog 1, ataxin 2-binding protein 1, fox-1 homolog A, fox-1-like RNA-binding protein 1, hexaribonucleotide binding protein 1 isoform alpha, hexaribonucleotide binding protein 1 isoform beta, hexaribonucleotide-binding protein 1
Species: human

Top Publications

  1. ncbi Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism
    Christa Lese Martin
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Am J Med Genet B Neuropsychiatr Genet 144:869-76. 2007
  2. pmc Two iron-responsive promoter elements control expression of FOX1 in Chlamydomonas reinhardtii
    Xiaodong Deng
    Umea Plant Science Center, Umea University, SE 901 87 Umea, Sweden
    Eukaryot Cell 6:2163-7. 2007
  3. pmc Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins
    Hua Lin Zhou
    Department of Genetics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Mol Cell Biol 28:5507-16. 2008
  4. pmc Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
    Chaolin Zhang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 22:2550-63. 2008
  5. doi The Ustilago maydis forkhead transcription factor Fox1 is involved in the regulation of genes required for the attenuation of plant defenses during pathogenic development
    Alexander Zahiri
    Karlsruhe Institute of Technology, Institute for Applied Biosciences, Department of Genetics, D 76187 Karlsruhe, Germany
    Mol Plant Microbe Interact 23:1118-29. 2010
  6. pmc Genome-wide analysis of survival in early-stage non-small-cell lung cancer
    Yen Tsung Huang
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 27:2660-7. 2009
  7. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
  8. pmc Fox-1 family of RNA-binding proteins
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Cell Mol Life Sci 66:3895-907. 2009
  9. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010
  10. pmc Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
    John C Castle
    Rosetta Inpharmatics LLC, Seattle, WA 98109, USA
    Nat Genet 40:1416-25. 2008

Research Grants

  1. Developmental Programs of Neural Circuits in the Mouse Medial Hypothalamus
    Holly A Ingraham; Fiscal Year: 2013
  2. Herbert M Lachman; Fiscal Year: 2016
  3. Kelsey C Martin; Fiscal Year: 2014
  4. The Role of Fox-1 in Neurodevelopment and Autistic Spectrum Disorder
    BRENT LINDEN FOGEL; Fiscal Year: 2013
  5. Gordon G Carmichael; Fiscal Year: 2016
  6. Julie Siegenthaler; Fiscal Year: 2014
  7. Programmed Changes in Alternative Splicing Within the Erythroid Transcriptome
    JOHN CONBOY; Fiscal Year: 2007
  8. Red Cell Band 4.1 - Developmental Changes in RNA Splicing
    JOHN CONBOY; Fiscal Year: 2008
  9. Red Cell Band 4.1 - Developmental Changes in RNA Splicing
    John G Conboy; Fiscal Year: 2010
  10. MATURATION OF CHLOROPLAST CYTOCHROMES
    Sabeeha Merchant; Fiscal Year: 2001

Scientific Experts

Detail Information

Publications98

  1. ncbi Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism
    Christa Lese Martin
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Am J Med Genet B Neuropsychiatr Genet 144:869-76. 2007
    ..7 Mb ataxin-2 binding protein-1 (A2BP1) gene, also called FOX1...
  2. pmc Two iron-responsive promoter elements control expression of FOX1 in Chlamydomonas reinhardtii
    Xiaodong Deng
    Umea Plant Science Center, Umea University, SE 901 87 Umea, Sweden
    Eukaryot Cell 6:2163-7. 2007
    b>FOX1 encodes an iron deficiency-induced ferroxidase involved in a high-affinity iron uptake system...
  3. pmc Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins
    Hua Lin Zhou
    Department of Genetics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Mol Cell Biol 28:5507-16. 2008
    ..These studies provide evidence for the first example of regulated E' complex formation. The two-step repression of presplicing complexes by a single regulator provides a powerful and accurate regulatory strategy...
  4. pmc Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
    Chaolin Zhang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 22:2550-63. 2008
    ..Here we comprehensively predict the targets of the brain- and muscle-specific splicing factor Fox-1 (A2BP1) and its paralog Fox-2 (RBM9) and systematically define the corresponding SRNs genome-wide...
  5. doi The Ustilago maydis forkhead transcription factor Fox1 is involved in the regulation of genes required for the attenuation of plant defenses during pathogenic development
    Alexander Zahiri
    Karlsruhe Institute of Technology, Institute for Applied Biosciences, Department of Genetics, D 76187 Karlsruhe, Germany
    Mol Plant Microbe Interact 23:1118-29. 2010
    ..In this study, we report the identification of a U. maydis forkhead transcription factor, Fox1, which is exclusively expressed during biotrophic development...
  6. pmc Genome-wide analysis of survival in early-stage non-small-cell lung cancer
    Yen Tsung Huang
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 27:2660-7. 2009
    ..We used genome-wide analysis of tumor tissue to investigate whether single nucleotide polymorphisms (SNPs) in tumors are prognostic factors in early-stage NSCLC...
  7. pmc A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
    G Zhai
    Department of Twin Research and Genetic Epidemiology, King s College London, UK
    J Med Genet 46:614-6. 2009
    ..The SNP is located in intron 1 of the A2BP1 gene...
  8. pmc Fox-1 family of RNA-binding proteins
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Cell Mol Life Sci 66:3895-907. 2009
    ..Further systematic elucidation of target genes of the Fox-1 family and other splicing regulators in various tissues will lead to a comprehensive understanding of splicing regulatory networks...
  9. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010
    ..association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat...
  10. pmc Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
    John C Castle
    Rosetta Inpharmatics LLC, Seattle, WA 98109, USA
    Nat Genet 40:1416-25. 2008
    ..UCUCU and UGCAUG seem to have similar function but independent action, occurring 5' and 3', respectively, of 33% of the cassette exons upregulated in skeletal muscle but co-occurring for only 2%...
  11. pmc Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2
    Shuying Sun
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    RNA 18:274-83. 2012
    b>RBFOX1 and RBFOX2 are alternative splicing factors that are predominantly expressed in the brain and skeletal muscle...
  12. doi Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy
    Dennis Lal
    Cologne Center for Genomics, University of Cologne, Cologne, Germany
    Epilepsia 54:265-71. 2013
    Structural variations disrupting the gene encoding the neuron-specific splicing regulator RBFOX1 have been reported in three patients exhibiting epilepsy in comorbidity with other neuropsychiatric disorders...
  13. pmc Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
    Dwight Stambolian
    Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA
    Hum Mol Genet 22:2754-64. 2013
    ..This single nucleotide polymorphism (SNP) is located within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range of alternative splicing events implicated ..
  14. pmc Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing
    Hua Lin Zhou
    Department of Genetics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Mol Cell Biol 27:830-41. 2007
    ..These results define a critical role for Fox-1 and Fox-2 proteins in exon 4 inclusion of calcitonin/CGRP pre-mRNA and establish a regulatory network that controls the fate of exon 4...
  15. ncbi Identification and expression of a mouse ortholog of A2BP1
    T R Kiehl
    Rose Moss Laboratory for Parkinson and Neurodegenerative Diseases, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Mamm Genome 12:595-601. 2001
    ..It interacts at its C-terminus with ataxin-2 binding protein 1, A2BP1. This study presents a highly conserved mouse ortholog of A2BP1, designated A2bp1...
  16. pmc Molecular basis of RNA recognition by the human alternative splicing factor Fox-1
    Sigrid D Auweter
    Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    EMBO J 25:163-73. 2006
    ..These results demonstrate the unusual molecular mechanism of sequence-specific RNA recognition by Fox-1, which is exceptional in its high affinity for a defined but short sequence element...
  17. ncbi Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16
    Julie L Ponthier
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 281:12468-74. 2006
    ....
  18. pmc Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals
    Jason G Underwood
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095 1662, USA
    Mol Cell Biol 25:10005-16. 2005
    ..They do this through a splicing enhancer function, in addition to their apparent negative effects on splicing in vertebrate muscle and in worms...
  19. ncbi A novel protein with RNA-binding motifs interacts with ataxin-2
    H Shibata
    Division of Neurology and Rose Moss Laboratory for Parkinson and Neurodegenerative Diseases, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Hum Mol Genet 9:1303-13. 2000
    ..Using the yeast two-hybrid system, we identified a novel protein, A2BP1 (ataxin-2 binding protein 1) which binds to the C-terminus of ataxin-2...
  20. pmc A genome-wide association study of sleep habits and insomnia
    Enda M Byrne
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Med Genet B Neuropsychiatr Genet 162:439-51. 2013
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing...
  21. pmc N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats
    Jiefu Lin
    Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou 510642, China
    J Diabetes Res 2016:9213034. 2016
    ..N-Acetylcysteine restored Sevo-postC cardioprotection in diabetes possibly through enhancing cardiac p-STAT3 and adiponectin and reducing Fox1 and CD36.
  22. pmc Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes
    Ji Ann Lee
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 89:113-28. 2016
    Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a candidate gene for autism spectrum disorders...
  23. doi Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy
    Jin Li
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104
    J Immunol 195:1599-607. 2015
    ..CNVs in a second gene (RBFOX1) showed a significant association (p = 7...
  24. pmc RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish
    Karen S Frese
    Department of Medicine III, University of Heidelberg, D 69120 Heidelberg, Germany German Centre for Cardiovascular Research DZHK, partner site Heidelberg Mannheim, D 69120 Heidelberg, Germany
    J Cell Sci 128:3030-40. 2015
    ..Here, we investigated the functional role of the splicing regulator rbfox1 in vivo using the zebrafish as a model system...
  25. doi A2BP1 gene polymorphisms association with olanzapine-induced weight gain
    Licai Dong
    Institute of Mental Health, Sixth Hospital, Peking University, Beijing, 100191, China Key Laboratory of Mental Health, Ministry of Health and National Clinical Research Centerfor Mental Disorders Peking University, Beijing, 100191, China
    Pharmacol Res 99:155-61. 2015
    The ataxin-2 binding protein 1 (A2BP1) gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity...
  26. pmc Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion
    Neel Sengupta
    Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark St, Whitechapel, London, E1 2AT, UK
    Mol Cancer 12:1. 2013
    ..Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features...
  27. pmc Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects
    Yun Kyung Hahn
    Department of Anatomy and Neurobiology, MCV Campus, Virginia Commonwealth University, P O Box 980709, Richmond, VA 23298 0709, USA
    Curr HIV Res 13:10-20. 2015
    ..was recently identified as the RNA-binding, feminizing locus on X-3 (Rbfox3), a member of the larger, mammalian Fox1 family of RNA binding proteins...
  28. pmc Genome-wide association study and meta-analysis of intraocular pressure
    A Bilge Ozel
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genet 133:41-57. 2014
    ..These results confirm the involvement of common variants in multiple genomic regions in regulating IOP and/or glaucoma risk...
  29. pmc RBFOX1 and RBFOX3 mutations in rolandic epilepsy
    Dennis Lal
    Cologne Center for Genomics, University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne, Germany Department of Neuropediatrics, University Medical Clinic Giessen, Giessen, Germany
    PLoS ONE 8:e73323. 2013
    Partial deletions of the gene encoding the neuronal splicing regulator RBFOX1 have been reported in a range of neurodevelopmental diseases, including idiopathic generalized epilepsy...
  30. pmc Orchestration of neurodevelopmental programs by RBFOX1: implications for autism spectrum disorder
    Brent R Bill
    Department of Psychiatry, David Geffen School of Medicine, Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA
    Int Rev Neurobiol 113:251-67. 2013
    ..To gain clinical insight, it is critical to develop a comprehensive understanding of these genetic components. RBFOX1, an RNA splicing factor, regulates expression of large genetic networks during early neuronal development, and ..
  31. doi Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genes
    Abdul Noor
    Molecular Neuropsychiatry and Development Lab, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 165:303-13. 2014
    ..such as DLG1, DLG2, DPP6, NRXN1, NRXN2, NRXN3, SHANK2, and EPHA5, as well as the neuronal splicing regulator RBFOX1 (A2BP1), and neuronal cell adhesion molecule CHL1. We have also identified recurrent CNVs on 15q13.3 and 16p11...
  32. doi Deregulated FOX genes in Hodgkin lymphoma
    Stefan Nagel
    Department of Human and Animal Cell Lines, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
    Genes Chromosomes Cancer 53:917-33. 2014
    ....
  33. pmc Mechanistic Insights into the Binding of Class IIa HDAC Inhibitors toward Spinocerebellar Ataxia Type-2: A 3D-QSAR and Pharmacophore Modeling Approach
    Siddharth Sinha
    Department of Biotechnology, TERI University New Delhi, India
    Front Neurosci 10:606. 2016
    ..e., CREB-binding protein (CBP), Ataxin-2 binding protein 1 (A2BP1) leading to a state of hypo-acetylation and transcriptional repression...
  34. pmc RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1
    Roscoe Klinck
    Department of Microbiology and Infectiology, Faculty of Medicine and Heath Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada Laboratory of Functional Genomics, Faculty of Medicine and Heath Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 9:e107324. 2014
    ..alterations occurring in adult DM1 tissues, one produced a dominant negative variant of the splicing regulator RBFOX1. Notably, half of the splicing events controlled by MBNL1 were co-regulated by RBFOX1, and several events in this ..
  35. pmc RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts
    Yang I Li
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genome Res 25:1-13. 2015
    ..Our analyses suggest that accurate regulation of micro-exon inclusion by RBFOX proteins and PTBP1 plays an important role in the maintenance of tissue-specific protein-protein interactions. ..
  36. ncbi Genetic markers of osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, Kings College London, Lambeth Palace Rd, London SE1 7EH, United Kingdom
    Curr Rheumatol Rev 6:257-67. 2010
    ..PTGS2/PLA2G4A) and a locus on chr 7q22 associated with knee OA and a gene involved transcriptional regulation (A2BP1) to be associated with hand OA...
  37. ncbi Nerve impulses regulate myelination through purinergic signalling
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bethesda, MD 20892, USA
    Novartis Found Symp 276:148-58; discussion 158-61, 233-7, 275-81. 2006
    ..addition to P2 receptors on both types of glia, four types of P1 receptors are present in OPCs, but only A2A and A2BP1 receptors are detected in mouse SCs...
  38. pmc Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, Singapore
    Nat Genet 43:1139-41. 2011
    ..08 × 10(-10), per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue...
  39. pmc From the Cover: Neutralization of terminal differentiation in gliomagenesis
    Jian Hu
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:14520-7. 2013
    ..development that also sustain copy number loss in GBM through antineoplastic assay and identified A2BP1 (ataxin 2 binding protein 1, Rbfox1), an RNA-binding and splicing regulator that is deleted in 10% of GBM cases...
  40. doi Biochemical and morphological characterization of A2BP1 in neuronal tissue
    Nanako Hamada
    Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    J Neurosci Res 91:1303-11. 2013
    b>A2BP1 is considered to regulate alternative splicing of important neuronal transcripts and has been implicated in a variety of neurological and developmental disorders...
  41. pmc Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines
    Geula Klorin
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Genet 206:191-205. 2013
    ..For the first time, LINGO2, RBFOX1/A2BP1, RPL29, DUSP7, and CCSER1/FAM190A were found to be homozygously deleted in MMt, and some of these genes ..
  42. doi Frequent genomic loss at chr16p13.2 is associated with poor prognosis in colorectal cancer
    Claus Lindbjerg Andersen
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Int J Cancer 129:1848-58. 2011
    ..No transcriptional consequences of the losses were observed, and the only gene, A2BP1, located in the region showed no mutations...
  43. pmc An eQTL mapping approach reveals that rare variants in the SEMA5A regulatory network impact autism risk
    Ye Cheng
    Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA
    Hum Mol Genet 22:2960-72. 2013
    ..The SEMA5A regulatory network includes previous autism candidate genes and regions, including MACROD2, A2BP1, MCPH1, MAST4, CDH8, CADM1, FOXP1, AUTS2, MBD5, 7q21, 20p, USH2A, KIRREL3, DBF4B and RELN, among others...
  44. doi Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 101:1261-9. 2010
    ..LOH of AB051467, PTPRD, A2BP1, and C20orf133 was detected in more than 35% of gastric cancer tissues...
  45. pmc Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders
    Mingyan Lin
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e44017. 2012
    ..These included a number of putative SZ and ASD candidates, such as A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1...
  46. pmc Rare inherited A2BP1 deletion in a proband with autism and developmental hemiparesis
    L K Davis
    Department of Psychiatry, University of Illinois, Chicago, Illinois 60637, USA
    Am J Med Genet A 158:1654-61. 2012
    b>Ataxin 2 binding protein 1 (A2BP1 aka FOX1, RBFOX1) is an RNA binding protein responsible for regulation of pre-mRNA splicing events in a number of critical developmental genes expressed in muscle, heart and neuronal cells [Shibata et al...
  47. doi Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
    ..functional genomics to date in the field of bipolar disorder, yielding a series of novel (such as Klf12, Aldh1a1, A2bp1, Ak3l1, Rorb, Rora) and previously known (such as Bdnf, Arntl, Gsk3b, Disc1, Nrg1, Htr2a) candidate genes, blood ..
  48. pmc Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress
    Liat Amir-Zilberstein
    Department of Molecular Cell Biology, Weizmann Institute of Science, P O Box 26, Rehovot 76100, Israel
    Neuron 73:279-91. 2012
    ..factor Orthopedia modulates the expression of CRH as well as the splicing factor Ataxin 2-Binding Protein-1 (A2BP1/Rbfox-1)...
  49. ncbi The de novo chromosome 16 translocations of two patients with abnormal phenotypes (mental retardation and epilepsy) disrupt the A2BP1 gene
    Kavita Bhalla
    Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Hum Genet 49:308-11. 2004
    ..The mapping data showed both translocations disrupted the ataxin-2-binding protein 1 ( A2BP1) gene that encompasses a large genomic region of 1.7 Mb...
  50. pmc Copper-dependent iron assimilation pathway in the model photosynthetic eukaryote Chlamydomonas reinhardtii
    Sharon La Fontaine
    Department of Chemistry and Biochemistry, University of California, Los Angeles 90095 1569, USA
    Eukaryot Cell 1:736-57. 2002
    ..They include a multicopper ferroxidase (encoded by Fox1), an iron permease (encoded by Ftr1), a copper chaperone (encoded byAtx1), and a copper-transporting ATPase...
  51. doi Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders
    Fady M Mikhail
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    Am J Med Genet A 155:2386-96. 2011
    ..3, MEF2C at 5q14.3, andCAMAT1at 1p36.23p36.31), neuron-specific splicing factor genes (RBFOX1 at 16p13.2p13.3), genes involved in synapse formation and maintenance (CNTNAP2 at 7q35 and LRFN5 at 14q21...
  52. pmc Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays
    Hannah C Cheung
    Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genomics 9:216. 2008
    ..Validation studies were performed using RT-PCR on glioma cell lines, patient tumor and nontumor brain samples...
  53. pmc Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ
    Zhiguang Su
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 49:1500-10. 2008
    ..We suggest several candidate genes: Gba2 on Chr 4, Irs2 on Chr 8, and Ppargc1b on Chr 18 for TG; A2bp1 on Chr 16 for FFA; and G6pc2 on Chr 2 and Timp3 on Chr 10 for glucose.
  54. pmc A ferroxidase encoded by FOX1 contributes to iron assimilation under conditions of poor iron nutrition in Chlamydomonas
    Jen Chih Chen
    Department of Chemistry and Biochemistry, Box 951569, University of California Los Angeles, Los Angeles, CA 90095 1569, USA
    Eukaryot Cell 7:541-5. 2008
    When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway...
  55. doi Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan
    Edmund J S Sonuga-Barke
    Developmental Brain Behaviour Unit, University of Southampton, Southampton, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1359-68. 2008
    ..We find evidence for the role of EE in moderating the effects of genes on ADHD severity and comorbid conduct disorder, implicating both novel and established candidates. These findings need replicating in larger independent samples...
  56. doi Exclusion of a PAX6, FOXC1, PITX2, and MYCN mutation in another patient with apple peel intestinal atresia, ocular anomalies and microcephaly and review of the literature
    Yolande van Bever
    Department of Clinical Genetics, Erasmus Medical Centre Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Med Genet A 146:500-4. 2008
    ..Mutation analysis of the PAX6, FOX1, PITX2, and MYNC genes was normal as was MLPA for these genes...
  57. pmc Alternative splicing events identified in human embryonic stem cells and neural progenitors
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA
    PLoS Comput Biol 3:1951-67. 2007
    ..Lastly, comparative sequence analysis revealed conserved intronic cis-regulatory elements such as the FOX1/2 binding site GCAUG as being proximal to candidate AS exons, suggesting that FOX1/2 may participate in the ..
  58. pmc The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
    Lauren T Gehman
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA
    Nat Genet 43:706-11. 2011
    ..We show here that central nervous system-specific deletion of the gene encoding Rbfox1 results in heightened susceptibility to spontaneous and kainic acid-induced seizures...
  59. pmc FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii
    Michael D Allen
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 1569, USA
    Eukaryot Cell 6:1841-52. 2007
    Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas. In this work, we survey the version 3...
  60. pmc A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing
    Debopriya Das
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Nucleic Acids Res 35:4845-57. 2007
    ..The most prominent downstream motifs were binding sites for Fox1- and CELF-related splicing factors, and a branchpoint-like element acuaac; pyrimidine-rich elements resembling PTB-..
  61. pmc Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America
    PLoS Genet 3:e85. 2007
    ..Finally, we discovered that for Nova1, neuronal PTB, hnRNP C, and FOX1, the most frequently occurring ISRE proximal to an alternative conserved exon in the splicing factor strongly ..
  62. ncbi [The effect of NAD kinase homologues on the beta-oxidation of unsaturated fatty acids with the double bond at an even position in Saccharomyces cerevisiae]
    Feng Shi
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214036, China
    Sheng Wu Gong Cheng Xue Bao 22:667-71. 2006
    ..was examined, with wild type BY4742 as positive control cell, and fatty-acyl-CoA oxidase gene deletion mutant (fox1) and peroxisomal NADP-dependent isocitrate dehydrogenase isoenzymes gene deletion mutant (idp3) as negative control ..
  63. ncbi Between a rock and a hard place: trace element nutrition in Chlamydomonas
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, Box 951569, University of California Los Angeles, Los Angeles, CA 90095 1569, USA
    Biochim Biophys Acta 1763:578-94. 2006
    ..g., Fox1, Ftr1, Fre1, Fer1, Ctr1/2) as well as novel molecules involved in copper and iron nutrition (Crr1, Fea1/2)...
  64. ncbi Generation and characterization of Sca2 (ataxin-2) knockout mice
    Tim Rasmus Kiehl
    Rose Moss Laboratory for Parkinson and Neurodegenerative Diseases, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Biochem Biophys Res Commun 339:17-24. 2006
    ..Its interaction with A2BP1/Fox-1, a protein with an RNA recognition motif, suggests involvement of ataxin-2 in mRNA translation or transport...
  65. pmc Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT
    Gabrielle Barnby
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:950-66. 2005
    ..In the present study, 10 positional candidate genes that map to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1...
  66. pmc Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities
    Shingo Nakahata
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD 20892, USA
    Nucleic Acids Res 33:2078-89. 2005
    ..In mammals, there are at least two Fox-1-related genes, ataxin-2 binding protein 1 (A2BP1)/Fox-1 and Fxh/Rbm9, which encode an identical RRM...
  67. ncbi An integrative approach to gain insights into the cellular function of human ataxin-2
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Mol Biol 346:203-14. 2005
    ..However, ATX2 interacts with A2BP1, a protein containing an RNA-recognition motif, and the existence of an interaction motif for the C-terminal ..
  68. ncbi The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans
    T R Kiehl
    Rose Moss Laboratory for Parkinson and Neurodegenerative Diseases, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Mol Neurosci 15:231-41. 2000
    ..Ataxin-2 interacts with ataxin-2-binding-protein 1 (A2BP1), a member of a novel family of putative RNA-binding proteins...
  69. ncbi Measurement of hydrogen peroxide in biological samples containing high levels of ascorbic acid
    G Bleau
    Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, Canada
    Anal Biochem 263:13-7. 1998
    ..In the present study, we used the method of ferrous oxidation of xylenol orange (FOX1 assay) performed in a nitrogen atmosphere to accurately measure low levels of hydrogen peroxide, even in the ..
  70. pmc Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    J Steroid Biochem Mol Biol 122:186-92. 2010
    ..01). In conclusion, we identified several SNPs that were associated with vitamin D metabolite concentrations in Hispanics. These candidate polymorphisms merit further investigation in independent populations and other ethnicities...
  71. doi An Fe deficiency responsive element with a core sequence of TGGCA regulates the expression of FEA1 in Chlamydomonas reinharditii
    Xiaowen Fei
    Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou, China
    J Biochem 146:157-66. 2009
    ..In previous studies, we have identified FOX1 and ATX1 FEREs (Fe deficiency-responsive elements) as important regulation components of iron response in this ..
  72. doi Photo-oxidative stress impacts the expression of genes encoding iron metabolism components in Chlamydomonas
    Joanne C Long
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA
    Photochem Photobiol 84:1395-403. 2008
    ..At the RNA level, the abundance of ferroxidase (FOX1), iron reductase (FRE1), iron assimilatory protein (FEA1) and ferritin (FER1) mRNAs is also decreased...
  73. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  74. pmc Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes
    J Elia
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 15:637-46. 2010
    ..enriched for genes reported as candidates in studies of autism, schizophrenia and Tourette syndrome, including A2BP1, AUTS2, CNTNAP2 and IMMP2L...
  75. pmc Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins
    Zhen Zhi Tang
    Howard Hughes Medical Institute, University of California at Los Angeles, Los Angeles, California 90095 1662, USA
    Mol Cell Biol 29:4757-65. 2009
    ..Conversely, overexpression of Fox1 and Fox2 proteins represses exon 9* and enhances exon 33 splicing in the endogenous CaV1.2 mRNA...
  76. pmc Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept
    M L Hamshere
    Biostatistics and Bioinformatics Unit and Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 195:23-9. 2009
    ..Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research...
  77. pmc An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons
    Ji Ann Lee
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 23:2284-93. 2009
    ..We show that Fox-1/Ataxin 2-Binding Protein 1 (A2BP1), a protein implicated in a variety of neurological diseases, can counteract the effects of chronic depolarization ..
  78. pmc Genomewide association study of movement-related adverse antipsychotic effects
    Karolina Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Psychiatry 67:279-82. 2010
    ..Understanding individual differences in the development of extrapyramidal side effects (EPS) as a response to antipsychotic therapy is essential to individualize treatment...
  79. pmc Autoregulation of Fox protein expression to produce dominant negative splicing factors
    Andrey Damianov
    Howard Hughes Medical Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    RNA 16:405-16. 2010
    ..Each of the three mammalian paralogs, Fox-1 (A2BP1), Fox-2 (RBM9), and Fox-3 (HRNBP3), produces proteins with a single RNA-binding domain (RRM) flanked by N- and C-..
  80. doi A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
    Satoru Joshita
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Hum Immunol 71:520-4. 2010
    ..on chromosome 16p showed the strongest evidence of linkage, the protein-coding gene ataxin 2-binding protein 1 (A2BP1) lying 27 kb on the centromeric side of D16S423 was targeted as a candidate susceptible gene...
  81. pmc A novel negative Fe-deficiency-responsive element and a TGGCA-type-like FeRE control the expression of FTR1 in Chlamydomonas reinhardtii
    Xiaowen Fei
    Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Science, Haikou 571101, China
    J Biomed Biotechnol 2010:790247. 2010
    We have reported three Fe-deficiency-responsive elements (FEREs), FOX1, ATX1, and FEA1, all of which are positive regulatory elements in response to iron deficiency in Chlamydomonas reinhardtii...
  82. pmc Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts
    Mads Aarhus
    Centre for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Cerebrospinal Fluid Res 7:6. 2010
    ..The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes...
  83. pmc Analysis of the high-affinity iron uptake system at the Chlamydomonas reinhardtii plasma membrane
    Alaina Terzulli
    Department of Biochemistry, The University at Buffalo, 140 Farber Hall, 3435 Main St, Buffalo, NY 14214, USA
    Eukaryot Cell 9:815-26. 2010
    ..Chlamydomonas FOX1 is a homolog of the human ferroxidases but likely supports iron uptake in a manner similar to that of yeast, since ..
  84. ncbi The cooperative roles of Foxc1 and Foxc2 in cardiovascular development
    Tsutomu Kume
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, Tennessee 37232 6300, USA
    Adv Exp Med Biol 665:63-77. 2009
    b>Fox1 and Foxc2 are closely related members of the Forkhead/Fox transcription factor family...
  85. doi Pontocerebellar hypoplasia in association with de novo 19p13.11p13.12 microdeletion
    Natalie M Gallant
    Departments of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Med Genet A 155:2871-8. 2011
    ..Notably, the patient reported here also has a partial deletion of RBFOX1 (A2BP1), which lies within the autism susceptibility locus on 16p13.2...
  86. pmc Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts
    Omür Y Tastan
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9148, USA
    Development 137:3167-76. 2010
    ..the early development of germline cysts depends on the Drosophila homolog of the human ataxin 2-binding protein 1 (A2BP1) gene...
  87. pmc The Fox1 ferroxidase of Chlamydomonas reinhardtii: a new multicopper oxidase structural paradigm
    Alaina J Terzulli
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Biol Inorg Chem 14:315-25. 2009
    ..Chlamydomonas reinhardtii expresses a putative ferroxidase, Fox1, which has sequence similarity to human Cp (hCp)...
  88. doi Genetics of digital osteoarthritis
    Laetitia Michou
    Department of Medicine, CHUQ CHUL Research Center, Laval University, Canada
    Joint Bone Spine 78:347-51. 2011
    ..A recently published genome-wide association study showed that an A2BP1 gene polymorphism was significantly associated with hand osteoarthritis...
  89. doi Effects of chromium picolinate supplementation on the growth, carcass quality and gene expression of beef during the finishing period
    Liu Guifen
    Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China
    Mol Biol Rep 38:4469-74. 2011
    ..05), but mRNA expression amount of FOX1, FSTL and MATR3 always had same trends whatever in liver or muscle tissues...
  90. pmc Fox-3 and PSF interact to activate neural cell-specific alternative splicing
    Kee K Kim
    Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 39:3064-78. 2011
    Fox-1 family (Fox) proteins, which consist of Fox-1 (A2BP1), Fox-2 (Rbm9) and Fox-3 (NeuN) in mammals, bind to the RNA element UGCAUG and regulate alternative pre-mRNA splicing...
  91. pmc Genetic mapping of vascular calcified plaque loci on chromosome 16p in European Americans from the diabetes heart study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 75:222-35. 2011
    ..71 at 16.0 cM) was also observed. The strongest evidence for association with CarCP was observed with SNPs in the A2BP1 gene region (rs4337300 P= 0.005) with modest evidence of association with SNPs in CACNA1H (P= 0.010-0.033)...
  92. pmc Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1)
    Elizabeth A D Hammock
    Department of Pediatrics, Vanderbilt University School of Medicine and Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tenn 37232, USA
    Dev Neurosci 33:64-74. 2011
    The neuronal transcription splicing factor, A2BP1, has been implicated in a variety of neurodevelopmental disorders; however, the role of A2BP1 in brain development and gene regulatory function remains to be explicated...
  93. doi Complex congenital heart defects in association with maternal diabetes and partial deletion of the A2BP1 gene
    Seema Lale
    Department of Pathology, University of Missouri, Kansas City, Missouri, USA
    Fetal Pediatr Pathol 30:161-6. 2011
    ..Genomic studies identified a 162 kb intragenic deletion of A2BP1 gene within chromosome band 16p13.2...
  94. doi Definition and testing of the GROMOS force-field versions 54A7 and 54B7
    Nathan Schmid
    Laboratory of Physical Chemistry, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Eur Biophys J 40:843-56. 2011
    ..The new helical propensity modification is tested using the benchmark proteins hen egg-white lysozyme, fox1 RNA binding domain, chorismate mutase and the GCN4-p1 peptide...
  95. ncbi British society of echocardiography accreditation - the 'gold standard' for acute medicine
    Sarbjit Clare
    Consultant Acute Medicine, City Hospital, Dudley Road, Birmingham, B18 7QH
    Acute Med 7:144-5. 2008
    We read with interest to the article written by Kevin Fox1 and wholly support the notion that acute medical trainees who wish to undertaken echocardiography within the medical admissions unit (MAU) should achieve British Society of ..
  96. pmc Transcriptomic analysis of autistic brain reveals convergent molecular pathology
    Irina Voineagu
    Program in Neurogenetics and Neurobehavioral Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1769, USA
    Nature 474:380-4. 2011
    ..a neuronal module enriched for known autism susceptibility genes, including the neuronal specific splicing factor A2BP1 (also known as FOX1), and a module enriched for immune genes and glial markers...

Research Grants12

  1. Developmental Programs of Neural Circuits in the Mouse Medial Hypothalamus
    Holly A Ingraham; Fiscal Year: 2013
    ..2, FezF1 and A2bp1, affects VMH development and function...
  2. Herbert M Lachman; Fiscal Year: 2016
    ..addition, a statistically significant enrichment for SZ and ASD candidate genes was found, which included A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1...
  3. Kelsey C Martin; Fiscal Year: 2014
    ..More recently, human genetic studies identified the RNA binding protein Rbfox1 (also known as A2BP1) as another candidate autism gene...
  4. The Role of Fox-1 in Neurodevelopment and Autistic Spectrum Disorder
    BRENT LINDEN FOGEL; Fiscal Year: 2013
    ..One intriguing candidate is the Fox-1 gene (also called A2BP1). Several lines of evidence suggest that Fox-1 is an important neurodevelopmental factor...
  5. Gordon G Carmichael; Fiscal Year: 2016
    ..Of particular interest is the connection of the chr15 sno-lncRNAs to Fox1 family splicing regulators...
  6. Julie Siegenthaler; Fiscal Year: 2014
    ..of the meninges and defects in neocortical development differentially contribute to vascular malformations in Fox1 mutant mice...
  7. Programmed Changes in Alternative Splicing Within the Erythroid Transcriptome
    JOHN CONBOY; Fiscal Year: 2007
    ..Ultimately, methods for therapeutic correction of splicing defects, under development in model systems, may allow correction of such defects in erythroid cells as well. [unreadable] [unreadable] [unreadable]..
  8. Red Cell Band 4.1 - Developmental Changes in RNA Splicing
    JOHN CONBOY; Fiscal Year: 2008
    ..These studies should also provide insights into disease mechanisms caused by aberrant splicing, ultimately leading to splicing therapeutics to correct such defects. ..
  9. Red Cell Band 4.1 - Developmental Changes in RNA Splicing
    John G Conboy; Fiscal Year: 2010
    ..These studies should also provide insights into disease mechanisms caused by aberrant splicing, ultimately leading to splicing therapeutics to correct such defects. ..
  10. MATURATION OF CHLOROPLAST CYTOCHROMES
    Sabeeha Merchant; Fiscal Year: 2001
    ....
  11. Fox genes in urinary tract development
    Tsutomu Kume; Fiscal Year: 2005
    ..abstract_text> ..
  12. Nutritional Copper Signaling and Homeostasis
    Sabeeha Merchant; Fiscal Year: 2010
    ..for high affinity iron uptake in a copper-deficient cell, determine its biochemical function in relation to Fox1 (ferroxidase) and Ftr1 (iron permease) function, and monitor its expression and sub-cellular location in response ..