RASA1

Summary

Gene Symbol: RASA1
Description: RAS p21 protein activator 1
Alias: CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP, ras GTPase-activating protein 1, RAS p21 protein activator (GTPase activating protein) 1, p120 RAS GTPase activating protein, triphosphatase-activating protein
Species: human

Top Publications

  1. ncbi Mechanical analysis of tendon suture techniques
    D P Greenwald
    Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston
    J Hand Surg Am 19:641-7. 1994
  2. ncbi Mortality trends in Belgium and The Netherlands. Closing the gap
    J V Joossens
    Department of Epidemiology, University of Leuven, Belgium
    Acta Cardiol 51:9-25. 1996
  3. ncbi A morphological study of the fibrous capsule of the human lumbar facet joint
    T Yamashita
    Department of Orthopaedic Surgery, Sapporo Medical University, Japan
    Spine (Phila Pa 1976) 21:538-43. 1996
  4. ncbi Axonal regeneration stimulated by the combination of nerve growth factor and ciliary neurotrophic factor in an end-to-side model
    W V McCallister
    Department of Orthopaedics, University of Washington School of Medicine, Seattle, WA 98195 6500, USA
    J Hand Surg Am 26:478-88. 2001
  5. ncbi Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness
    T Kikuchi
    Department of Otolaryngology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Med Electron Microsc 33:51-6. 2000
  6. pmc MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1)
    Defang Sun
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, 22 Hankou Road, Nanjing 210093, PR China
    J Biol Chem 288:9508-18. 2013
  7. doi Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation
    Stefania Madonna
    Laboratory of Immunology, IDI IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 22:3287-97. 2008
  8. ncbi Specificity of the binding of synapsin I to Src homology 3 domains
    F Onofri
    Department of Experimental Medicine, Section of Physiology, University of Genova, Via Benedetto XV 3, I 16132 Genova, Italy
    J Biol Chem 275:29857-67. 2000
  9. ncbi Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
    N A Cacalano
    DNAX Research Institute, 901 California Avenue, Palo Alto, California 94304, USA
    Nat Cell Biol 3:460-5. 2001
  10. ncbi Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
    R M Stephens
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Neuron 12:691-705. 1994

Research Grants

  1. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
  2. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
  3. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
  4. Virginijus Valiunas; Fiscal Year: 2015
  5. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012
  6. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
  7. Guy A Perkins; Fiscal Year: 2015
  8. Paul D Lampe; Fiscal Year: 2016
  9. Paul L Sorgen; Fiscal Year: 2016
  10. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013

Detail Information

Publications1085 found, 100 shown here

  1. ncbi Mechanical analysis of tendon suture techniques
    D P Greenwald
    Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston
    J Hand Surg Am 19:641-7. 1994
    ..Tenorrhaphies were pulled apart at constant speed until a gap of 1 mm was observed. Strength (maximum stress) and toughness (energy absorption to gap formation) were calculated...
  2. ncbi Mortality trends in Belgium and The Netherlands. Closing the gap
    J V Joossens
    Department of Epidemiology, University of Leuven, Belgium
    Acta Cardiol 51:9-25. 1996
    ..The mortality gap between both countries is closing, especially between The Netherlands and Flanders...
  3. ncbi A morphological study of the fibrous capsule of the human lumbar facet joint
    T Yamashita
    Department of Orthopaedic Surgery, Sapporo Medical University, Japan
    Spine (Phila Pa 1976) 21:538-43. 1996
    ..superior and middle part of the joint, the fibers run in the medial to lateral direction, crossing over the joint gap. In the inferior part of the joint, the fibers are relatively long and run in a superior-medial to inferior-lateral ..
  4. ncbi Axonal regeneration stimulated by the combination of nerve growth factor and ciliary neurotrophic factor in an end-to-side model
    W V McCallister
    Department of Orthopaedics, University of Washington School of Medicine, Seattle, WA 98195 6500, USA
    J Hand Surg Am 26:478-88. 2001
    ..coaptation only, end-to-side coaptation plus growth factor injection, primary repair, and nontransferred gap control...
  5. ncbi Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness
    T Kikuchi
    Department of Otolaryngology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Med Electron Microsc 33:51-6. 2000
    In the mammalian cochlea, there are two independent gap junction systems, the epithelial cell gap junction system and the connective tissue cell gap junction system...
  6. pmc MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1)
    Defang Sun
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, 22 Hankou Road, Nanjing 210093, PR China
    J Biol Chem 288:9508-18. 2013
    ..candidate targets of miR-31 using bioinformatics approaches and validated RAS p21 GTPase activating protein 1 (RASA1) as a direct target. First, we found an inverse correlation between miR-31 and RASA1 protein levels in vivo...
  7. doi Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation
    Stefania Madonna
    Laboratory of Immunology, IDI IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 22:3287-97. 2008
    ..Moreover, SOCS1 interacted with the RAS inhibitor p120 RasGAP and promoted its degradation after IFN-gamma stimulation...
  8. ncbi Specificity of the binding of synapsin I to Src homology 3 domains
    F Onofri
    Department of Experimental Medicine, Section of Physiology, University of Genova, Via Benedetto XV 3, I 16132 Genova, Italy
    J Biol Chem 275:29857-67. 2000
    ..The ability to bind multiple SH3 domains further implicates the synapsins in signal transduction and protein-protein interactions at the nerve terminal level...
  9. ncbi Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
    N A Cacalano
    DNAX Research Institute, 901 California Avenue, Palo Alto, California 94304, USA
    Nat Cell Biol 3:460-5. 2001
    ..204 and 221 at the carboxy terminus, and upon phosphorylation tyrosine 221 interacts with the Ras inhibitor p120 RasGAP. After IL-2 stimulation, phosphorylated SOCS-3 strongly inhibits STAT5 activation but, by binding to RasGAP, ..
  10. ncbi Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
    R M Stephens
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Neuron 12:691-705. 1994
    ..These results suggest a model whereby Trk receptors utilize at least partially redundant signal transduction pathways to mediate NGF responses...
  11. ncbi Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1
    Hyangkyu Lee
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 277:34556-67. 2002
    ..In support of this notion, we identify several SH2 domain containing proteins, namely c-Src, NCK, and Ras-GAP, that interact with caveolin-2 in a phosphorylation-dependent manner...
  12. ncbi The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway
    Dakun Wang
    Department of Urology, Department of Pathology and Laboratory Medicine, and The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 280:16393-401. 2005
    ..SSB-1 protein bound to p120Ras-GTPase-activating protein (GAP) but did not promote the degradation of p120RasGAP, indicating that enhanced HGF-MET signaling by overexpression of SSB-1 was not dependent on p120RasGAP ..
  13. pmc Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase
    C M Pleiman
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206
    Mol Cell Biol 13:5877-87. 1993
    ..gamma 1) and C-gamma 2 (PLC gamma 2), phosphatidylinositol 3-kinase (PI 3-K), and p21ras-GTPase-activating protein (GAP)...
  14. ncbi Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
    T B van Dijk
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 96:3406-13. 2000
    ..These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling...
  15. ncbi Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins
    Veronique Gigoux
    Laboratoire de Pharmacochimie Moléculaire et Structurale, CNRS FRE2463 INSERM U266, UFR des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    J Biol Chem 277:23742-6. 2002
    The GTPase-activating protein RasGAP functions as both a negative regulator and an effector of Ras proteins. In tumor cells, RasGAP is no longer able to deactivate oncogenic Ras proteins, and its effector function becomes predominant...
  16. ncbi The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase
    Jesse A Flaxenburg
    Division of Nephrology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 172:7503-9. 2004
    ..We believe our findings are of importance in several chronic inflammatory diseases, including atherosclerosis and allograft rejection associated with both CD40-CD40 ligand signaling as well as VEGF expression and function...
  17. ncbi Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines
    B Druker
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 79:2215-20. 1992
    ..We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines...
  18. ncbi Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus
    J Settleman
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Cell 69:539-49. 1992
    ..stimulated and tyrosine kinase-transformed cells, a substantial fraction of the ras GTPase-activating protein (GAP) forms a complex with a protein termed p190. We have cloned several cDNAs encoding the p190 protein...
  19. ncbi Binding of GAP to activated PDGF receptors
    A Kazlauskas
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 247:1578-81. 1990
    ..products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused ..
  20. ncbi Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines
    T Mitsudomi
    NCI Navy Medical Oncology Branch, National Cancer Institute and National Naval Medical Center, Bethesda, MD 20889 5105
    Hum Genet 93:27-31. 1994
    ..in its GTP-bound form and insensitive to the hydrolytic action of the ras-specific GTPase-activating protein (ras GAP)...
  21. pmc A Ras-GTPase-activating protein SH3-domain-binding protein
    F Parker
    Gene Medicine Department, Rhone Poulenc Rorer, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
    Mol Cell Biol 16:2561-9. 1996
    We report the purification of a Ras-GTPase-activating protein (GAP)-binding protein, G3BP, a ubiquitously expressed cytosolic 68-kDa protein that coimmunoprecipitates with GAP...
  22. ncbi Ras-GTPase activating protein (GAP): a putative effector for Ras
    B Tocque
    RPR Gene Medicine, CRVA, Vitry Seine, France
    Cell Signal 9:153-8. 1997
    One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological ..
  23. ncbi The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
    K Scheffzek
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Rheinlanddamm 201, 44139 Dortmund, Germany
    Science 277:333-8. 1997
    ..diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms...
  24. pmc Role of p120 Ras-GAP in directed cell movement
    S V Kulkarni
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5
    J Cell Biol 149:457-70. 2000
    We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration...
  25. pmc Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations
    Iiro Eerola
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    Am J Hum Genet 73:1240-9. 2003
    ..A positional candidate gene, RASA1, encoding p120-RasGAP, was screened for mutations in 17 families...
  26. ncbi Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
    Timothy P Hecker
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 23:3962-71. 2004
    ..The overexpression of FAK also promoted the association of FAK with p120RasGAP, which is a negative regulator of Ras activity, in the U-251MG cells cultured in aggregate suspension, with this ..
  27. ncbi RASA1: variable phenotype with capillary and arteriovenous malformations
    Laurence M Boon
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and University of Louvain Medical School, Brussels, Belgium
    Curr Opin Genet Dev 15:265-9. 2005
    ..Candidate gene screening pinpointed mutations in RASA1 (p120-RASGAP) - a RasGTPase. RASA1 reverts active GTP-bound Ras into inactive GDP-bound form...
  28. pmc Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane
    William D Bradley
    Department of Molecular Biophysics and Biochemistry, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA
    Mol Biol Cell 17:4827-36. 2006
    ..p190 phosphorylation promotes its binding to p120RasGAP (p120). Here, we elucidate the mechanism by which p120 binding regulates p190 activation after adhesion...
  29. doi A novel mutation in RASA1 causes capillary malformation and limb enlargement
    Dov Hershkovitz
    Department of Dermatology and Laboratory of Molecular Dermatology, Rambam Health Care Campus, Haifa, Israel
    Arch Dermatol Res 300:385-8. 2008
    ..Mutations in the RASA1 gene have been shown to underlie the capillary malformation-arterio-venous malformation (CM-AVM) syndrome, ..
  30. pmc A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells
    Alok Tomar
    University of California San Diego, Moores Cancer Center, Department of Reproductive Medicine, La Jolla, CA 92093, USA
    J Cell Sci 122:1852-62. 2009
    ..and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation...
  31. pmc MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
    Sudarshan Anand
    Department of Pathology, University of California, San Diego, California, USA
    Nat Med 16:909-14. 2010
    ..Here we show that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducing neovascularization...
  32. doi Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene
    Robert S de Wijn
    Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Med Genet 55:191-5. 2012
    Hereditary capillary malformations are known to be caused by mutations in the RASA1 gene. The associated phenotype is still subject of debate...
  33. pmc A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability
    I E Gallouzi
    Institut de Genetique Moleculaire de Montpellier, UMR 5535 CNRS, Universite Montpellier II, F34293 Montpellier Cedex 5, France
    Mol Cell Biol 18:3956-65. 1998
    A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP...
  34. pmc Multiple SH2-mediated interactions in v-src-transformed cells
    C A Koch
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 12:1366-74. 1992
    ..and transforming proteins, including cytoplasmic protein-tyrosine kinases and Ras GTPase-activating protein (GAP)...
  35. ncbi Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
    C Ellis
    Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Nature 343:377-81. 1990
    ..The presence of two adjacent SH2 domains in the p21ras GTPase-activating protein (GAP) indicates that GAP might interact directly with tyrosine kinases...
  36. ncbi Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product
    M Frech
    Max Planck Institute für medizinische Forschung, Abteilung Biophysik, Heidelberg, Germany
    Science 249:169-71. 1990
    ..to Ras-p21 proteins in the region where interaction with guanosine triphosphatase (GTPase) activating protein (GAP) is believed to occur. Therefore, the ability of GAP to interact with Rap1A-p21 was tested...
  37. pmc Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor
    M Reedijk
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 10:5601-8. 1990
    ..In fibroblasts, CSF-1 stimulation also induced the phosphorylation of the GTPase-activating protein (GAP)-associated protein p62 on tyrosine, although GAP itself was a relatively poor substrate...
  38. ncbi Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors
    D Anderson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 250:979-82. 1990
    Phospholipase C gamma 1 (PLC gamma 1) and p21ras guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are phosphorylated by activated growth factor receptors...
  39. ncbi Molecular cloning of two types of GAP complementary DNA from human placenta
    M Trahey
    Department of Molecular Biology, Cetus Corp, Emeryville, CA 94608
    Science 242:1697-700. 1988
    The ras p21 GTPase-activating protein (GAP) was purified from human placental tissue...
  40. ncbi Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo
    H Kozutsumi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Oncogene 9:2991-8. 1994
    ..tyrosine-phosphorylated in vivo and associated with SH2 containing proteins, PLC-gamma 1, p85 subunit of PI3-K and GAP, in vivo. Furthermore, the wild-type ltk protein also binds to a serine/threonine kinase, Raf-1, in vivo...
  41. pmc Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation
    K Q Hu
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    EMBO J 16:473-83. 1997
    ..p120 RasGAP (GTPase-activating protein), which contains an SH3 domain flanked by two SH2 domains, forms an abundant SH2-..
  42. doi Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations
    Nicole Revencu
    Laboratory of Human Molecular Genetics, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Hum Mutat 29:959-65. 2008
    ..malformation (CM-AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations and the associated phenotype in 44 families...
  43. doi Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration
    Perayot Pamonsinlapatham
    Laboratoire de Pharmacochimie Moleculaire et Cellulaire, Universite Paris Descartes, Unités de Formation et de Recherche UFR Biomédicale, 45 Rue des Saints Peres, 75270, Paris Cedex 06, France
    Cell Signal 20:2119-26. 2008
    Ras GTPase-activating protein (RasGAP) is hypothesized to be an effector of oncogenic Ras stimulating numerous downstream cellular signaling cascades involved in survival, proliferation and motility...
  44. ncbi Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein
    S W Rabkin
    University of British Columbia, Department of Medicine, Vancouver, Canada
    Am J Hypertens 9:230-6. 1996
    ..to identify this protein, immunoblotting was carried out with antibodies to the signal transducing proteins rasGAP, JAK2 iNOS, p125FAK, and the Src substrate, pp120, but all proved negative...
  45. ncbi Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras
    M Segal
    Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel
    J Biol Chem 267:22747-51. 1992
    ..the RAS1 and RAS2 loci, expressing both p21H-ras and the catalytic domain of the bovine GTPase activating protein (GAP) and containing the cdc25-2 mutation. Such a strain exhibits a temperature-sensitive phenotype...
  46. ncbi Antagonistic effects of NES and NLS motifs determine S. cerevisiae Rna1p subcellular distribution
    W Feng
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 112:339-47. 1999
    ..The data support the hypothesis that Rna1p exists on both sides of the nuclear membrane, perhaps regulating the Ran-GTP/Ran-GDP gradient, participating in a complete RanGTPase nuclear cycle or serving a novel function...
  47. ncbi Dynamics of the COPII coat with GTP and stable analogues
    B Antonny
    Department of Molecular and Cell Biology, Howard Hugues Medical Institute, Stanley Hall, University of California, Berkeley, California 94720, USA
    Nat Cell Biol 3:531-7. 2001
    ..Experiments with the phosphate analogue BeFx suggest that Sec23/24p provides residues directly involved in GTP hydrolysis on Sar1p...
  48. ncbi Influence of neonatal estrogens on rat prostate development
    G S Prins
    Department of Urology, University of Illinois at Chicago, 60612, USA
    Reprod Fertil Dev 13:241-52. 2001
    ..altered steroid receptor expression include disruption of TGFbeta paracrine communication, altered expression of gap junction connexin molecules and loss of epithelial cadherin on epithelial cells...
  49. ncbi [Not Available]
    A Carlino
    Istituto Universitario Europeo, Firenze
    Physis Riv Int Stor Sci 31:731-69. 1994
    ..In many ways, anatomical fugitive sheets are exceptional documents through which one can measure the gap between academic knowledge and popularization and identify the iconographic and textual strategies used in order to ..
  50. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
    ..j.ps) produced by electrical field stimulation (EFS) were investigated by means of a sucrose-gap technique in the circular muscle of the guinea-pig colon. 2...
  51. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
    ..5. In electrophysiological experiments (sucrose gap), cromakalim (0.3 and 1 microM) produced hyperpolarization of ureter smooth muscle...
  52. pmc Emerging issues in lifestyle, social, and environmental interventions to promote behavioral change related to prevention and control of hypertension in the African-American population
    C H Edwards
    Howard University, Washington, DC, USA
    J Natl Med Assoc 87:642-6. 1995
    ..In conclusion, we already have the information we need from research to close the mortality gap between whites and African Americans in cardiovascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)
  53. pmc Action of purine and pyrimidine nucleotides on the rat superior cervical ganglion
    G P Connolly
    Department of Physiology, University College of London
    Br J Pharmacol 110:1297-304. 1993
    1. Using a grease-gap technique, we have investigated the effects of purine and pyrimidine nucleotides on the d.c. potential of the rat isolated superior cervical ganglion (SCG). 2...
  54. pmc Detachment of agglutinin-bonded red blood cells. II. Mechanical energies to separate large contact areas
    E Evans
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Biophys J 59:849-60. 1991
    ..solutions of a high molecular weight polymer to draw the surfaces together by osmotic dehydration of the adhesion gap. These stresses exceeded initial mechanical assembly stresses by up to three orders of magnitude...
  55. ncbi Clinical results of unconventional fractionation radiotherapy in central nervous system tumors
    M Botturi
    Radiotherapy Department, Ospedale Niguarda Ca' Granda, Milan, Italy
    Tumori 84:176-87. 1998
    ..Different considerations have been proposed to explain this gap between theory and clinical data...
  56. pmc Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis
    P Santicioli
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:1149-58. 1995
    ..6. In sucrose gap experiments, (S)-ketoprofen (10-100 microM) produced a time-dependent shortening of spontaneous action potentials ..
  57. pmc Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve: implications for P2 purinoceptor classification
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 113:463-70. 1994
    1. By use of a 'grease-gap' technique, the depolarizing effects of adenosine 5'-triphosphate (ATP) and ATP analogues on the rat isolated vagus nerve were determined in normal and in Ca2+/Mg(2+)-free (+ 1 x 10(-3) M ethylenediamine ..
  58. pmc Delayed depolarization and slow sodium currents in cutaneous afferents
    O Honmou
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510
    J Neurophysiol 71:1627-37. 1994
    ..Whole-nerve sucrose gap recordings were obtained from the SN and the ATN...
  59. pmc Effect of the Ca(2+)-ATPase inhibitor, cyclopiazonic acid, on electromechanical coupling in the guinea-pig ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:127-37. 1995
    ..8. In sucrose gap experiments, 10 micro M CPA produced a sustained depolarization of the membrane and reduced the latency between ..
  60. ncbi The Taskforce 2000 survey on medical education in sleep and sleep disorders
    R Rosen
    Comprehensive Sleep Disorders Center, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, USA
    Sleep 21:235-8. 1998
    Previous research has shown evidence of a widening gap between scientific research and clinical teaching in sleep and sleep disorders...
  61. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    ..stimulation (EFS) in the circular muscle of the guinea-pig proximal colon was investigated by means of a sucrose-gap technique. 2. In the presence of 1 microM atropine, submaximal EFS (10 Hz, 20-30 V, 0...
  62. ncbi Development of artificial articular cartilage
    M Oka
    Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Japan
    Proc Inst Mech Eng H 214:59-68. 2000
    ..As regards lubrication, the changes in thickness and fluid pressure of the gap formed between a glass plate and the specimen under loading were measured and it was found that PVA-H had a thicker ..
  63. pmc Effects of PAF on excitatory neuro-effector transmission in dog airways
    K Tashiro
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 107:956-63. 1992
    ..bronchiole of the dog were investigated, by isometric tension recording, microelectrode and double sucrose-gap methods. 2...
  64. ncbi The influence of social class on health status: American and British research on health inequalities
    O Fein
    Cornell University Medical College, New York, New York 10021, USA
    J Gen Intern Med 10:577-86. 1995
    ..Use of British and American standardized mortality ratios (SMRs) shows that the gap between the advantaged upper socioeconomic classes and the disadvantaged lower classes has become wider from 1930 ..
  65. ncbi [Analysis of the current status of asthma education for children and adolescents in German-speaking countries]
    R Szczepanski

    Pneumologie 47:583-7. 1993
    ..An analysis conducted in mid-1992 revealed a considerable gap between the actual need for such training and the available training facilities...
  66. ncbi [Fragile X syndrome and mental retardation]
    A Estévez-González
    Departamento de Psiquiatría y Psicobiología Clínica, Universidad de Barcelona, Espana
    Rev Neurol 25:1068-71. 1997
    Fragile-X syndrome is characterized by the presence of a fragile site (gap) on Xq 27.3 and the transcriptional inhibition of a mRNA protein-binding gene called FMR-1...
  67. pmc Safety and efficacy of fertility-regulating methods: a decade of research
    D C Skegg
    University of Otago, Dunedin, New Zealand
    Bull World Health Organ 77:713-21. 1999
    An international venture was launched in 1985 to fill a recognized gap in post-marketing surveillance of fertility-regulating methods...
  68. ncbi Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco
    S C McKarns
    Research and Development, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA
    Toxicol In Vitro 14:41-51. 2000
    ..b>Gap junction intercellular communication (GJIC) and lactate dehydrogenase release (LDH) were used to quantify ..
  69. ncbi [Facioscapulohumeral muscular dystrophy (FSH) and hearing loss]
    T Takeya
    Department of Pediatrics, University of Tsukuba
    No To Hattatsu 22:24-9. 1990
    ..In case 1, pure tone audiograms revealed high tone hearing loss without an A-B gap. On speech audiography, the maximum articulation score was 100% and proved normal. The tympanogram was type A...
  70. ncbi Silica induced suppression of the production of third and fifth components of the complement system by human lung cells in vitro
    B L Rothman
    Department of Pathology, University of Connecticut Health Center, Farmington
    Immunopharmacol Immunotoxicol 16:525-51. 1994
    ..To begin to fill this gap in our knowledge we have recently evaluated the ability of lung tissue cells to synthesize and secrete various ..
  71. pmc The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by alpha, beta-methylene adenosine 5'-triphosphate
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 112:282-8. 1994
    ..5'-triphosphate (alpha, beta-methylene ATP), depolarizes the rat cervical vagus nerve, measured with a 'grease-gap' extracellular recording technique. This effect was attenuated by the P2 purinoceptor antagonist, suramin...
  72. pmc Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 110:1055-60. 1993
    ..investigated on the extracellularly recorded membrane potential of the rat isolated vagus nerve, using a 'grease-gap' technique. 2. ATP evoked depolarization of the rat vagus nerve...
  73. ncbi Is early gastric cancer, diffuse type, a forerunner of advanced gastric cancer
    P Leocata
    Dipartimento di Medicina Sperimentale, , Italy
    Tumori 79:108-11. 1993
    ..RESULTS: On an average, patients affected by EGC were 8.1 years younger than those with AGC. This age gap could support the hypothesis that early lesions represent the first stage of AGC...
  74. ncbi Immunohistochemical demonstration of the gap junctional protein connexin 32 and proliferating cell nuclear antigen in glutathione S-transferase placental form-negative lesions of rat liver induced by diethylnitrosamine and clofibrate
    S Ito
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Toxicol Pathol 24:690-5. 1996
    The distributions of a gap junctional protein, connexin 32 (cx 32), and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically in glutathione S-transferase placental form (GST-P)-negative foci, induced in rat liver ..
  75. ncbi Should the gap be filled between guidelines and actual practice for management of low back pain in primary care? The Quebec experience
    M Rossignol
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 21:2893-8; discussion 2898-9. 1996
    ..A prospective cohort study...
  76. ncbi Duration of antituberculosis chemotherapy in conjunction with radical surgery in the management of spinal tuberculosis
    S S Upadhyay
    Duchess of Kent Children s Hospital, Hong Kong
    Spine (Phila Pa 1976) 21:1898-903. 1996
    ..6 years after radical resection of the tuberculous lesion and reconstruction of the resultant gap with bone graft...
  77. pmc Attitudes towards war, killing, and punishment of children among young people in Estonia, Finland, Romania, the Russian Federation, and the USA
    A McAlister
    University of Texas Houston School of Public Health, Houston, TX, USA
    Bull World Health Organ 79:382-7. 2001
    ..CONCLUSION: The results confirm the gap between the US and European groups in moral disengagement attitudes and tendencies that could lead to deadly ..
  78. pmc Bradykinin receptors in mouse and rat isolated superior cervical ganglia
    G R Seabrook
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
    Br J Pharmacol 115:368-72. 1995
    ..and its analogues to depolarize rat and mouse superior cervical ganglia was studied by use of in vitro grease-gap recording techniques, and the ability of antagonists selective for bradykinin receptor subtypes to block their ..
  79. pmc Discrimination between UTP- and P2-purinoceptor-mediated depolarization of rat superior cervical ganglia by 4,4'-diisothiocyanatostilbene-2,2'- disulphonate (DIDS) and uniblue A
    G P Connolly
    Department of Physiology, University College London
    Br J Pharmacol 115:427-32. 1995
    1. Using a grease-gap recording technique we have investigated the effects of some antagonists of P2-purinoceptors on the depolarization of the rat isolated superior cervical ganglion evoked by 100 microM alpha, beta-methylene-adenosine ..
  80. pmc Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
    J Harvey
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 109:1085-90. 1993
    1. A grease-gap recording technique has been used to investigate the mechanisms underlying the acute potentiation of N-methyl-D-aspartate (NMDA) responses by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) in area CA1 of rat ..
  81. ncbi Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors
    M F Sugrue
    Merck Research Laboratories, West Point, PA 19486, USA
    Prog Retin Eye Res 19:87-112. 2000
    There was a time gap of over 40 years between the demonstrated oral effectiveness of acetazolamide in lowering the intraocular pressure (IOP) of glaucoma patients and the introduction of a topical carbonic anhydrase (CA) inhibitor...
  82. pmc Charge movement and SR calcium release in frog skeletal muscle can be related by a Hodgkin-Huxley model with four gating particles
    B J Simon
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550
    Biophys J 61:1109-16. 1992
    ..delta[Ca2+]) were measured simultaneously in frog skeletal muscle fibers, voltage clamped in a double vaseline gap chamber, using Antipyrylazo III as the calcium indicator...
  83. ncbi Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443
    D Hebebrand
    UCLA Hand Center, USA
    J Hand Surg Br 22:304-7. 1997
    ..Sciatic nerve grafts of 2 cm were transplanted from donor Golden Syrian hamsters into a 0.5 cm gap in the sciatic nerve of recipient Lewis rats...
  84. ncbi Electromechanical uncoupling in a molluscan muscle examined by the sucrose gap technique. The effect of calcium antagonist and agonist agents
    H Huddart
    Department of Zoology, University of Rhode Island, Kingston, 02881
    J Comp Physiol B 158:501-12. 1988
    Membrane potential and tension of Busycon radular protractor muscles were studied by sucrose gap methods...
  85. ncbi Physicians' and nurses' attitudes toward withholding treatment in a community hospital
    M W Frampton
    Myers Community Hospital, Sodus, New York
    J Gen Intern Med 2:394-9. 1987
    ..A significant communication gap existed between nurses and physicians regarding aggressiveness of care: physicians indicated communication with ..
  86. pmc A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated
    J V Kilmartin
    MRC Laboratory of Molecular Biology, Cambridge, England
    J Cell Biol 123:1175-84. 1993
    ..The 110-kD component is localized in the SPB to the gap between the central plaque and the sealed ends of the nuclear microtubules near the inner plaque (Rout, M., and J...
  87. ncbi A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests
    T Shirai
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 25:453-60. 1997
    ..system for rapid detection of carcinogenic agents has been developed using male Fischer 344 rats to bridge the gap between long-term carcinogenicity tests and short-term screening assays...
  88. ncbi Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    R L Sorenson
    Department of Cell Biology and Neuroanatomy, University of Minnesota Medical School, Minneapolis 55455, USA
    Horm Metab Res 29:301-7. 1997
    ..secretion, 2) increased insulin synthesis, 3) increased beta-cell proliferation and islet volume, 4) increased gap-junctional coupling among beta-cells, 5) increased glucose metabolism, and 6) increased c-AMP metabolism...
  89. ncbi Innervation of a lizard auditory organ having gap junctions between most hair cells: a serial transmission electron microscopy study
    M R Miller
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Comp Neurol 293:223-35. 1990
    ..4. An unusual finding was the presence of gap junctions directly interconnecting more than half the hair cells in both papillar segments...
  90. ncbi [Fatal lactic acidosis in a patient with acquired immunodeficiency syndrome treated with stavudine, lamivudine and indinavir]
    K Tanaka
    First Department of Internal Medicine, Kurume University School of Medicine
    Kansenshogaku Zasshi 73:1232-5. 1999
    ..Laboratory data demonstrated a severe metabolic acidosis with an anion gap due to lactate accumulation...
  91. ncbi Genetic expression for type I procollagen in the early stages of flexor tendon healing
    R H Gelberman
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston
    J Hand Surg Am 17:551-8. 1992
    ..localized specifically to the epitenon cells on the tendon surface overlying the repair site and to cells in the gap between the tendon stumps. No detectable expression was noted in endotenon fibroblasts...
  92. pmc Employers, the government, and industrial fatigue in Britain, 1890-1918
    A J McIvor
    Department of History, University of Strathclyde, Glasgow, UK
    Br J Ind Med 44:724-32. 1987
    ..Though there are significant caveats, it is argued that before the first world war a wide gap existed between research findings, best practice, and the common workshop experience and that in general British ..
  93. ncbi Cloning of the region between HLA-DMB and LMP2 in the human major histocompatibility complex
    P Sanseau
    Department of Human Immunogenetics, Imperial Cancer Research Fund, England
    Hum Immunol 40:1-7. 1994
    ..Almost all of the class II region of the MHC has already been cloned in cosmids but a gap remained between the DMB and LMP2 genes...
  94. ncbi Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain
    Y Zheng
    Department of Pharmacology, Cornell University, Ithaca, New York 14853
    J Biol Chem 268:24629-34. 1993
    ..These members include human platelet GAP for Cdc42Hs (the human homolog of a S...
  95. ncbi Mechanisms of load transfer in the cadaver forearm: role of the interosseous membrane
    K L Markolf
    Biomechanics Research Section, Department of Orthopaedic Surgery, University of California at Los Angeles, USA
    J Hand Surg Am 25:674-82. 2000
    ..With varus alignment (initial gap between the radial head and capitellum) load applied to the wrist displaced the radius proximally an average of 1...
  96. ncbi Gap junctional intercellular communication of bovine granulosa and thecal cells from antral follicles: effects of luteinizing hormone and follicle-stimulating hormone
    Mary Lynn Johnson
    Endocrine 18:261-70. 2002
    ..We have shown that LH or FSH affect cellular interactions mediated by gap junctions in bovine granulosa and thecal cells in vitro...
  97. ncbi Heterocellular gap junctional communication between alveolar epithelial cells
    V Abraham
    Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1085-93. 2001
    We analyzed the pattern of gap junction protein (connexin) expression in vivo by indirect immunofluorescence...
  98. ncbi An application of neutron activation and radiotracer techniques for studying the status of sodium in the bone mineral
    N Pilecká
    Institute of Biophysics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 39:49-56. 1993
    ..The experiments on the bone in vitro can help to bridge a gap between in vitro experiments on synthetic hydroxy apatite and dynamic studies based on the in vivo neutron ..
  99. ncbi Comparison of ideal and actual behavior of patients and dentists during dental treatment
    S Lahti
    Department of Community Dentistry, University of Kuopio, Kuopio, Finland
    Community Dent Oral Epidemiol 23:374-8. 1995
    ..In general, there evidently is a clear gap in communication between dentists and patients, which may lead to frustration on both sides...
  100. ncbi Radiographic evaluation of osseous displacement following intra-articular fractures of the distal radius: reliability of plain radiography versus computed tomography
    R J Cole
    Orthopaedic Clinic, Memphis, TN, USA
    J Hand Surg Am 22:792-800. 1997
    ..The average maximum gap displacement on plain radiographs was 2.1 mm (range, 0.0-15.0 mm, lateral view) and on CT images was 4...
  101. ncbi Review on prostaglandin and oxytocin activity in preterm labor
    M Ivanisevic
    University Hospital for Gynaecology and Obstetrics, School of Medicine, University of Zagreb, Croatia
    Coll Antropol 25:687-94. 2001
    ..uterine contractions and indirectly to increase fundally dominant myometrial contractility by up regulation of gap junctions, oxytocin and arginine vasopressin receptors and synchronizations of contractions...

Research Grants89

  1. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..b>Gap junctions, which are formed of proteins called connexins, are a special class of cell junctions that provide a ..
  2. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
    ..The 5-year overall survival for patients with PDA is less than 3%. The gap junction protein connexin43 (Cx43) is a tumor suppressor gene that is expressed in pancreatic ductal cells, the ..
  3. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..Our laboratory recently identified mutations (missense and small duplication) in the gap junction protein GJA1, also referred to as connexin 43, in ODDD patients...
  4. Virginijus Valiunas; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Gap junctions provide a direct intercellular pathway for cell-to-cell signaling and impulse conduction and play an important role in normal physiology...
  5. Connexin 43 Hemichannels and Signaling In Bone
    LILIAN IRENE PLOTKIN; Fiscal Year: 2012
    ..Thus, mechanical stimulation increases Cx43 expression, gap junction communication and hemichannel opening in osteoblasts and osteocytes...
  6. Connexin Distribution in Physiological Versus Pathological Cardiac Hypertrophy
    Michael R Zile; Fiscal Year: 2013
    ..network organization and MAP4 binding in causing abnormal transport and localization of connexin43 [Cx43], a gap junction protein known to undergo functionally important alterations in quantity and localization during ..
  7. Guy A Perkins; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Gap junctions create direct cell-cell communication in most cell types...
  8. Paul D Lampe; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Gap junctions are specialized matched membrane domains that contain channels that allow exchange of small molecules including ions, metabolites, and second messengers (e.g...
  9. Paul L Sorgen; Fiscal Year: 2016
    ..DESCRIPTION (provided by applicant): Connexins are integral membrane proteins that oligomerize to form intercellular gap junction channels...
  10. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gap junctions provide for the homeostasis of nearly every tissue by metabolically, chemically, and electrically coupling the cells into a functional syncytium...
  11. Connexin-Mediated Hemichannel Activity in Experimental Periodontitis
    Karen F Ross; Fiscal Year: 2012
    ..of this project is to characterize cell-to-cell communication in oral tissues through connexin hemichannels and gap junctions in order to design new treatments for infection of mucosal tissues...
  12. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..My losses include a colony of connexin43 (gap junction) mutant mice, generated as recipients for cell-transplantation studies, a breeding colony of rats, as well ..
  13. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
    ..The central hypothesis that will be tested is that both connexin gap junctions and hemichannels play an important role in maintaining lens transparency...
  14. SiRNA therapeutics: Gap junction delivery in vitro and in vivo
    Richard T Mathias; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cellular delivery of siRNA via gap junctions represents a unique and potentially clinically important delivery system...
  15. Mario Delmar; Fiscal Year: 2015
    ..Here, we seek a better understanding of the association between mechanical junctions, gap junctions and the voltage-gated sodium channel (VGSC) complex...
  16. LENS CELL COUPLING--ASSEMBLY AND ROLE OF GAP JUNCTIONS
    LINDA MUSIL; Fiscal Year: 1999
    ..Three closely related types of gap junction proteins (connexins) participate in joining lens cells into a syncytium with respect to molecules smaller ..
  17. Transfer of Metabolites through Lens Gap Junctions
    Gary Goldberg; Fiscal Year: 2005
    Lens cells require gap junction proteins to communicate with each other and develop properly. In particular, connexin43 (Cx43), Cx46, and Cx5O are needed for normal lens development and function...
  18. Regulation of lens connexins
    Charles Louis; Fiscal Year: 2007
    ..Regulation of connexin-mediated gap junctional communication, and intracellular cytosolic Ca 2+ concentration ([Ca2+]i) are essential for maintaining ..
  19. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Gap junctions are microscopic intercellular junctions that provide for direct intercellular ionic, electrical, and metabolic coupling between nerve cells in the brain, retina, and spinal cord...
  20. Electrical Synapses and Network Signaling
    Gianmaria Maccaferri; Fiscal Year: 2010
    ..the preferential synaptic targets of noradrenaline in the hippocampus are GABAergic interneurons, which express the gap junction protein Connexin 36, and are organized in electrically coupled networks...
  21. Functional activity in glia
    Gerald Dienel; Fiscal Year: 2009
    ..Astrocytes are highly coupled by gap junction channels, but the functional roles of the syncytium are not well understood because dye transfer studies ..
  22. Velia M Fowler; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The transparency of the vertebrate lens depends on assembly of connexins into gap junctions that are required for lens ionic homeostasis and metabolite circulation...
  23. Internalization of gap junctions as a regulatory mechanism of direct GJIC
    Matthias M Falk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Communication between adjacent cells through gap junctions (GJs) occurs in nearly every tissue and is fundamental to coordinated cell behavior during development, differentiation, and tissue ..
  24. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..flexneri, but it is injected into the host cell cytoplasm where it may be localized to gap junctions. Because IpaD may have a role in post-invasion events (i.e...
  25. Amir Tirosh; Fiscal Year: 2016
    ..In recent years, it has been shown that gap junction channels play a pivotal role in tissue adaptation to stress and inflammation in various tissues and ..
  26. Janis M Burt; Fiscal Year: 2014
    ..understand the molecular mechanisms that govern the permeability and growth suppressive properties of vascular cell gap junctions and 2) to develop from that knowledge the rationale for gene therapies that target connexin expression in ..
  27. Thomas W White; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Connexins are the subunit proteins of gap junctions, which allow the exchange of ions, second messengers and small metabolites between adjacent cells through intercellular channels...
  28. Connexin acetylation: Impact on gap junction function and HDAC inhibitor respons
    JEANNETTE CHLOE BULINSKI; Fiscal Year: 2010
    ..b>Gap junctions are channels formed from connexin subunits that permit the passive transfer of low molecular mass ..
  29. Pharmacology of Connexin Channels: Structure-Activity Studies.
    Miduturu Srinivas; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The multi-gene family of proteins called connexins form intercellular gap junctions that directly mediate signaling between adjacent cells...
  30. Mechanisms of coronary endothelial dysfunction in diabetes
    Ayako Makino; Fiscal Year: 2011
    ..b>Gap junctions, formed by connexins (Cxs), provide important pathways for the cell-cell communication and Cx40 is known ..
  31. Thomas W White; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Connexins are the subunit proteins of gap junctions, which allow the exchange of ions, second messengers and small metabolites between adjacent cells through intercellular channels...
  32. Structure and Dynamics of Gap Junction Channels
    MARK JAY YEAGER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gap junctions are specialized regions of cell-to-cell contact in which hexameric oligomers, called connexons, dock end-to-end across a narrow extracellular gap, allowing the intercellular exchange of ..
  33. International Gap Junction Conference 2013
    Robert G Gourdie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Virtually all cells in the human body form gap junctions...
  34. YURIY KUCHERYAVYKH; Fiscal Year: 2015
    ..Unlike normal glia, glioma cells express low levels of functional connexin (Cx) hemichannel/gap junction protein and high levels of polyamines (PA)...
  35. INFLAMMATORY MECHANISMS IN LUNG VASCULAR SEGMENTS
    Kaushik Parthasarathi; Fiscal Year: 2012
    ..We will inhibit intercellular communication by blocking gap junctions and connexin expression using pharmacological and molecular mechanisms...
  36. Osteoblastic lineage cells regulate osteoclastogenesis via Cx43 and gap junctions
    Yue Zhang; Fiscal Year: 2011
    ..b>Gap junctions (GJ) are membrane-spanning channels that allow passage of ions and signaling molecules, less than 1KD in ..
  37. William Smith; Fiscal Year: 2016
    ..The connexin proteins make gap junctions.) In embryos from the frimousse (frm) mutant line, the anterior neural plate is transfated to epidermis...
  38. Mitchell J Weiss; Fiscal Year: 2016
    ..and will test whether polarization of calcium communication is determined by selective permeability of the gap junctions at the MEJ or differential expression of second messenger receptors at the MEJ in the two cell types...
  39. CONNEXONS IN CARDIOVASCULAR CELL COMMUNICATION
    Eric C Beyer; Fiscal Year: 2013
    ..b>Gap junction channels are likely to play significant roles in the stabilization and maintenance of atrial fibrillation, ..
  40. Coronary Artery Regulation by Small Conduction Ca2+-activated K+ Channels
    MARK STEPHEN TAYLOR; Fiscal Year: 2011
    ..of these Ca2+ signals to holes in the internal elastic lamina (IEL) as well as to SK3 channels and specific gap junction connexins expressed along the endothelial-vascular smooth muscle (VSM) interface, suggest the existence of ..
  41. Guy A Perkins; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Gap junctions play dynamic roles in cellular processes, however, there is a fundamental knowledge gap in understanding how gap junction proteins, the connexins, are regulated and gated based on a ..
  42. ANAMIKA MARAGRET REED; Fiscal Year: 2014
    ..proposal hypothesizes that low pH exerts its injurious effects by transforming intracellular calcium signaling and gap junctional intercellular communication in acinar cells from a physiologic pattern to one that causes pancreatitis...
  43. Miduturu Srinivas; Fiscal Year: 2014
    Abstract Gap junctional communication provided by connexin channels is required for postnatal lens growth and transparency. Targeted deletions of genes encoding Cx46 and Cx50 lead to cataracts in mice...
  44. Control of Junctional Conductance at Auditory Afferent
    Alberto Pereda; Fiscal Year: 2009
    ..objective of the proposed research is to study the role and properties of electrical synaptic transmission via gap junctions in the CNS, in particular in the auditory system...
  45. Embryonic Expression and Roles of Neuronal Connexin 35 in Zebrafish Spinal Cord
    Tara Martin; Fiscal Year: 2013
    ..Electrical synapses are formed with gap junction communications between neuronal cells that allow for the direct transfer of current...
  46. Function and Expression of Connexins in the pre-Botzinger Complex
    JONATHAN KELTY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Gap junctions are pores that span the membranes of adjacent cells, and as such provide a means of electrical and cytoplasmic continuity between those cells...
  47. Jean X Jiang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Connexin-forming gap junction intercellular communication (GJIC) is essential for the metabolic homeostasis of the lens...
  48. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
    This Program Project of 26 years duration brings together investigators with a wide range of expertise to focus on gap unctions, which are intercellular channels comprised of connexins...
  49. MECHANISMS OF CONTROL OF CELL GROWTH BY GAP JUNCTIONS
    Bruce Nicholson; Fiscal Year: 2003
    The disruption of intercellular coupling through gap junctions has long been associated with cell transformation and that the promotion phase of tumorigenesis...
  50. Mario Delmar; Fiscal Year: 2016
    ..Since its inception (in 1999), we focused on the mechanisms that regulate gap junctions formed by Connexin43 (Cx43)...
  51. JOHN PEARCE MORROW; Fiscal Year: 2015
    ..this application is that increased cardiac myocyte lipid content leads to abnormal regulation of ion channels and gap junctions, promoting arrhythmia...
  52. Roberto Civitelli; Fiscal Year: 2016
    ..During the tenure of this project, we demonstrated that bone forming cells communicate via gap junctions formed primarily by connexin43 (Cx43)...
  53. Mechanisms for Stem Cell Differentiation into Cardiac Myocytes
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..More specifically, shared cytosolic conduits, gap junctions, between adult-derived stem cells and adjacent contracting cardiomyocytes provide the route by which a ..
  54. Development of a novel connexin-based peptide for the treatment of corneal injury
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2012
    ..ACT1 works by stabilizing gap junctions and maintaining intercellular communication between cells that is essential for wound repair or injury ..
  55. SIGNAL TRANSDUCTION AT FERTILIZATION
    Laurinda A Jaffe; Fiscal Year: 2012
    ..Recent findings, which establish that gap junctions between the somatic cells of the follicle close rapidly in response to LH, form the basis for the 3 aims ..
  56. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..leading to cardiac dysfunction is not known, however, recent studies have suggested involvement of cardiac gap junction remodeling...
  57. Electro-mechanical Resynchronization Therapy For Arrhythmogenic Right Ventricular
    Harikrishna Tandri; Fiscal Year: 2012
    ..activation delay in the RV, namely the localization and expression of the key conduction protein connexin-43 at the gap junctions, and its relation to electrical propagation;and 3)...
  58. Joshua M Hare; Fiscal Year: 2016
    ..engraftment and differentiation of mesenchymal stem cells (MSCs) in the injured porcine heart was accompanied by 1) gap junction formation with host cells, 2) stimulation of endogenous cardiac stem cell (CSC) proliferation and ..
  59. X Edward Guo; Fiscal Year: 2014
    ..calcium [Ca2+]i oscillations in osteocytic network, followed by prostaglandin E2 (PGE2) production/secretion via gap junctions/hemi-channels to OBs...
  60. Eliseo A Eugenin; Fiscal Year: 2016
    ..Nevertheless, our data demonstrate for first time that HIV infected astrocytes, through gap junction channels and perhaps hemichannels, can amplify inflammation and CNS damage...
  61. The Role of Gap Junctions in Peripheral Odor Coding
    Chunbo Zhang; Fiscal Year: 2004
    b>Gap junctions represent an important mode of intercellular communication in the nervous system. Gap junctions allow exchange of small bioactive substances, including second messengers, between coupled cells...
  62. Rafael Yuste; Fiscal Year: 2016
    ..role in the circuit: they tile the CNS with near- complet coverage, are connected into an extensive syncytium via gap junctions, and processes from a single astrocyte can contact up to tens of thousands of synapses...
  63. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..for uveal coloboma, an abnormal development of the eye caused by incomplete closure of a normally-occurring gap in the eye (the optic fissure) after the fifth week of life in a human embryo...
  64. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..for uveal coloboma, an abnormal development of the eye caused by incomplete closure of a normally-occurring gap in the eye (the optic fissure) after the fifth week of life in a human embryo...
  65. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  66. "Connexin-Dependent Transcriptomic Networks in Controlling the Heart Rhythm"
    DUMITRU ANDREI IACOBAS; Fiscal Year: 2010
    Extensive literature has reported altered expression and/or mutation of the primary gap junction proteins (connexins, Cx) that couple myocytes in ventricles (Cx43) and atria (Cx40) among major causes of cardiac arrhythmias...
  67. Adam C Miller; Fiscal Year: 2014
    ..formed in a regulated manner between only a subset of potentially available partners and are composed of neuronal gap junction channels...
  68. Richard T Mathias; Fiscal Year: 2014
    ..The circulation depends on fiber cell gap junctions to conduct intracellular fluxes of ions and perhaps fluid, which flow from the center to surface of the ..
  69. Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes
    PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013
    ..within the mineralized matrix of bone and communicate with one another and with osteoblasts and osteoclasts via gap junctions located at the ends of long cytoplasmic processes that course through tunnels (cannalicula) in the bone...
  70. Jonathan Savitz; Fiscal Year: 2016
    ..I am currently an assistant professor at the Laureate Institute for Brain Research (LIBR) focusing on bridging the gap between immune dysfunction and neuroimaging abnormalities in major depressive disorder (MDD)...
  71. Maria Diakonova; Fiscal Year: 2014
    ..both PAK1 and PRL have been implicated in breast cancer, the proposed studies may ultimately fill out the existing gap between upstream PRL-PRLR-JAK2 events and downstream PAK1-dependent functions in our understanding of the mechanism ..
  72. JAMES EWBANK HALL; Fiscal Year: 2016
    ..Lens cells have glucose transporters, chloride channels, sodium and potassium channels, gap junctions, and many other standard transport proteins in common with the cells of other organs...
  73. David W Piston; Fiscal Year: 2016
    ..This effect parallels that seen in islets lacking [unreadable]-cell gap junctions, where insulin secretion can be inhibited by juxtacrine communication mediated by ephrinA-EphA signaling ..
  74. Zhongcong Xie; Fiscal Year: 2016
    ..However, the pathogenesis of POCD is still largely unknown, and this gap in knowledge impedes further studies of POCD...
  75. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..The proposed research aims to study the role of gap junctions during the several days of "maturation" of neuronal injury after global ischemia...
  76. SHANNON LEIGH GOURLEY; Fiscal Year: 2016
    ..refinement: Brain-derived Neurotrophic Factor binding to the high- affinity trkB receptor and formation of the p120RasGAP-p190RhoGAP signaling complex...
  77. ALBERT HONG JAE KIM; Fiscal Year: 2016
    ..of novel Cdc20-APC downstream mechanisms in the control of dendrite morphogenesis will fill a significant gap in our understanding of cell-intrinsic mechanisms of neuronal connectivity and provide insights into the ..
  78. Jan A Nolta; Fiscal Year: 2015
    ..techniques we have determined that this cell-contact-dependent intercellular transfer does not occur through small gap junctions but rather through exosomal transport and direct shuttle of small RNA species through tunneling ..
  79. Stephen G Weber; Fiscal Year: 2014
    ..We also will develop a means to diminish the astrocytes'ability to communicate with each other through gap junctions based on focal electroporation of siRNA for the protein that creates the gap junctions...
  80. Xue Han; Fiscal Year: 2016
    ..how neurons work together in intact neural circuits to generate computations: electrical synapses, mediated by gap junction connections that directly electrically couple cells together...
  81. KAREN MARIE BUSSARD; Fiscal Year: 2014
    ..bone models that mimic human breast cancer metastasis in-vivo to determine if 1) breast cancer cells form gap junctions with bone stromal cells, 2) alterations in mesenchymal stem cell-derived factors regulate breast cancer ..
  82. Jean F Regal; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how placental ischemia during pregnancy leads to maternal hypertension and the only effective cure is early delivery of the placenta...
  83. VISUAL ADAPTATION IN THE VERTEBRATE RETINA
    Harris Ripps; Fiscal Year: 2005
    The vertebrate retina is a highly ordered neuronal network in which electrical coupling through gap junctions influences every aspect of retinal function...
  84. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..However, there is a significant gap in our knowledge and understanding of whether early exposure to certain bacteria also acts as an important ..
  85. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..In the testis, morphological studies in the 1970s reported the presence of desmosome-gap junctions (also known as desmosome-like junctions) between adjacent Sertoli cells at the blood-testis barrier, as ..
  86. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..Instead, other factors must be involved, but have yet to be identified. The overarching challenge and knowledge gap addressed by this grant is that we do not know the determinants of daily functioning in BPD...
  87. MYOMETRIAL GAP JUNCTION MODULATION IN PRETERM LABOR
    WILLIAM LARSEN; Fiscal Year: 1990
    ..both preterm and normal term labor is the rapid and dramatic development of a functional population of myometrial gap junctions in the final 24-72 hours prior to parturition...
  88. GAP JUNCTIONS AND LUTEAL FUNCTION
    ANNA GRAZUL BILSKA; Fiscal Year: 1999
    ..3), 4) the relationship of gap junctional intercellular communication with progesterone production by luteal cells (Exp...
  89. Increasing efficacy of antineoplastic drugs with gap junction enhancers
    Thu Annelise Nguyen; Fiscal Year: 2010
    ..Most normal cells have functional gap junctional intercellular communication (GJIC), while most, if not all, tumors cells have dysfunctional GJIC...